PMC:4548004 / 15539-18041 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4548004","sourcedb":"PMC","sourceid":"4548004","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4548004","text":"Representative histological features of 36-week-old male human apoB Tg. SHR-cp/cp rats are shown in Fig. 3\nFig. 3. Representative light micrographs of H\u0026E- (A-D), PAM- (E-H), and Oil Red O-stained (I, J) kidney sections from 36-week-old human apoB Tg. SHR-cp/cp (A, E, I), non-Tg. SHR-cp/cp (B, F, J), human apoB Tg. SHR-+/+ (C, G), and non-Tg. SHR-+/+ rats (D, H). Filled circles indicate hyaline casts. Arrows indicate dilated tubules. In the sections stained with Oil Red O (I, J), lipid droplets appeared as red spots and indicate the accumulation of neutral lipids in the glomeruli. K: The glomerulosclerosis score of the rats is shown. The number of rats is shown in parentheses. Values are shown as the mean ± SEM. Bars=100 μm. The asterisks indicate a significant difference at ††P\u003c0.01 compared with the human apoB Tg. SHR-cp/cp rats.. Human apoB Tg. SHR-cp/cp rats showed prominent hyaline casts and tubular degeneration/regeneration. The tubular changes were characterized by vacuolation and single-cell necrosis of the tubular epithelium, thickening of the basement membrane and tubular dilation. Mononuclear cell infiltration mainly consisting of lymphocytes was also observed in the interstitial region (Fig. 3A). These lesions were also seen in non-Tg. SHR-cp/cp rats (Fig. 3B); however, the severities in human apoB Tg. SHR-cp/cp rats were significantly higher than those in non-Tg. SHR-cp/cp rats (Table 2\nTable 2. Quantitative analysis of tubulointerstitial lesions in human apoB Tg. SHR-cp/cp rats\nApoB Tg. cp/cp Non-Tg. cp/cp ApoB Tg. +/+ Non-Tg. +/+\nn 9 8 7 7\nTubular degeneration/regeneration 2.9 ± 0.1 2.1 ± 0.1* 0.7 ± 0.2** 0.6 ± 0.2**\nMononuclear cell infiltration 2.8 ± 0.2 1.8 ± 0.2* 0.1 ± 0.2** 0.1 ± 0.2**\nHyaline cast 2.9 ± 0.1 2.3 ± 0.2* 0.9 ± 0.2** 0.7 ± 0.2**\nData are shown as the mean ± SE. *P\u003c0.05 and **P\u003c0.01 compared with human apoB Tg.-cp/cp rats.). Human apoB Tg. SHR-cp/cp rats also showed more severe glomerulosclerosis compared with non-Tg. SHR-cp/cp rats (Figs. 3E and 3F), and the glomerulosclerosis score in human apoB Tg. SHR-cp/cp rats was significantly higher than that in non-Tg. SHR-cp/cp rats (Fig. 3K). Few lipids were observed in the glomeruli of non-Tg. SHR-cp/cp rats (Fig. 3J), whereas more prominent lipid accumulation was observed in the glomeruli of all the human apoB Tg. SHR-cp/cp rats (Fig. 3I). Human apoB Tg. SHR-+/+ rats and non-Tg. SHR-+/+ rats showed no remarkable glomerular or tubulointerstitial changes (Figs. 3C, 3D, 3G, and 3H).","divisions":[{"label":"figure","span":{"begin":107,"end":843}},{"label":"label","span":{"begin":107,"end":114}},{"label":"caption","span":{"begin":115,"end":843}},{"label":"p","span":{"begin":115,"end":843}},{"label":"table-wrap","span":{"begin":1423,"end":1887}},{"label":"label","span":{"begin":1423,"end":1431}},{"label":"caption","span":{"begin":1432,"end":1516}},{"label":"title","span":{"begin":1432,"end":1516}},{"label":"table","span":{"begin":1517,"end":1792}},{"label":"tr","span":{"begin":1517,"end":1570}},{"label":"th","span":{"begin":1517,"end":1531}},{"label":"th","span":{"begin":1532,"end":1545}},{"label":"th","span":{"begin":1546,"end":1558}},{"label":"th","span":{"begin":1559,"end":1570}},{"label":"tr","span":{"begin":1571,"end":1580}},{"label":"td","span":{"begin":1571,"end":1572}},{"label":"td","span":{"begin":1573,"end":1574}},{"label":"td","span":{"begin":1575,"end":1576}},{"label":"td","span":{"begin":1577,"end":1578}},{"label":"td","span":{"begin":1579,"end":1580}},{"label":"tr","span":{"begin":1581,"end":1659}},{"label":"td","span":{"begin":1581,"end":1614}},{"label":"td","span":{"begin":1615,"end":1624}},{"label":"td","span":{"begin":1625,"end":1635}},{"label":"td","span":{"begin":1636,"end":1647}},{"label":"td","span":{"begin":1648,"end":1659}},{"label":"tr","span":{"begin":1660,"end":1734}},{"label":"td","span":{"begin":1660,"end":1689}},{"label":"td","span":{"begin":1690,"end":1699}},{"label":"td","span":{"begin":1700,"end":1710}},{"label":"td","span":{"begin":1711,"end":1722}},{"label":"td","span":{"begin":1723,"end":1734}},{"label":"tr","span":{"begin":1735,"end":1792}},{"label":"td","span":{"begin":1735,"end":1747}},{"label":"td","span":{"begin":1748,"end":1757}},{"label":"td","span":{"begin":1758,"end":1768}},{"label":"td","span":{"begin":1769,"end":1780}},{"label":"td","span":{"begin":1781,"end":1792}},{"label":"table-wrap-foot","span":{"begin":1793,"end":1887}},{"label":"p","span":{"begin":1793,"end":1887}}],"tracks":[]}