PMC:4537547 / 33357-34346 JSONTXT

{"project":"2_test","denotations":[{"id":"26275715-25342443-16696860","span":{"begin":109,"end":111},"obj":"25342443"},{"id":"26275715-21278746-16696861","span":{"begin":113,"end":115},"obj":"21278746"},{"id":"26275715-22532574-16696862","span":{"begin":135,"end":137},"obj":"22532574"},{"id":"26275715-25342443-16696863","span":{"begin":286,"end":288},"obj":"25342443"},{"id":"26275715-25342443-16696864","span":{"begin":374,"end":376},"obj":"25342443"},{"id":"26275715-21278746-16696865","span":{"begin":378,"end":380},"obj":"21278746"},{"id":"26275715-22266113-16696866","span":{"begin":616,"end":617},"obj":"22266113"},{"id":"26275715-22532574-16696867","span":{"begin":851,"end":853},"obj":"22532574"}],"text":"Ten loci have been identified by GWAS to be associated with percent mammographic density, ZNF365-rs10995190 [10, 30], 12q24-rs1265507 [31], and AREG-rs10034692, PRDM6-rs186749, ESR1-rs12665607, 8p11.23-rs7816345, LSP1-rs3817198, IGF1-rs703556, TMEM184B-rs7289126, and SGSM3-rs17001868 [10]. The ZNF365, ESR1, LSP1 and SGSM3 loci are also associated with breast cancer risk [10, 30], implicating a shared genetic basis of mammographic density and breast cancer. This is also supported by the findings of a study, which assessed a polygenic score based on mammographic density GWAS with respect to breast cancer risk [8]. Women in the top 10 % of the score had an associated 31 % increased risk of breast cancer compared to women in the bottom 10 % of the score. The locus on 12q24 on the other hand, seems not to be associated with breast cancer risk [31]. Our data indicated that associations of the SNPs identified by GWAS with mammographic density are unlikely to be modified by MHT use."}

{"project":"PubTator4TogoVar","denotations":[{"id":"11250","span":{"begin":167,"end":175},"obj":"SNP"},{"id":"11251","span":{"begin":149,"end":159},"obj":"SNP"},{"id":"11252","span":{"begin":253,"end":262},"obj":"SNP"},{"id":"11254","span":{"begin":234,"end":242},"obj":"SNP"},{"id":"11255","span":{"begin":182,"end":192},"obj":"SNP"},{"id":"11260","span":{"begin":202,"end":211},"obj":"SNP"},{"id":"11261","span":{"begin":218,"end":227},"obj":"SNP"},{"id":"11263","span":{"begin":124,"end":133},"obj":"SNP"},{"id":"11264","span":{"begin":274,"end":284},"obj":"SNP"},{"id":"11265","span":{"begin":97,"end":107},"obj":"SNP"}],"attributes":[{"id":"A11250","pred":"resolved_to","subj":"11250","obj":"tmVar:rs186749;VariantGroup:30;CorrespondingGene:93166;RS#:186749;CorrespondingSpecies:9606"},{"id":"A11251","pred":"resolved_to","subj":"11251","obj":"tmVar:rs10034692;VariantGroup:33;RS#:10034692"},{"id":"A11252","pred":"resolved_to","subj":"11252","obj":"tmVar:rs7289126;VariantGroup:13;CorrespondingGene:25829;RS#:7289126;CorrespondingSpecies:9606"},{"id":"A11254","pred":"resolved_to","subj":"11254","obj":"tmVar:rs703556;VariantGroup:3;RS#:703556"},{"id":"A11255","pred":"resolved_to","subj":"11255","obj":"tmVar:rs12665607;VariantGroup:34;RS#:12665607"},{"id":"A11260","pred":"resolved_to","subj":"11260","obj":"tmVar:rs7816345;VariantGroup:28;RS#:7816345"},{"id":"A11261","pred":"resolved_to","subj":"11261","obj":"tmVar:rs3817198;VariantGroup:16;CorrespondingGene:4046;RS#:3817198;CorrespondingSpecies:9606"},{"id":"A11263","pred":"resolved_to","subj":"11263","obj":"tmVar:rs1265507;VariantGroup:14;RS#:1265507"},{"id":"A11264","pred":"resolved_to","subj":"11264","obj":"tmVar:rs17001868;VariantGroup:26;CorrespondingGene:27352;RS#:17001868;CorrespondingSpecies:9606"},{"id":"A11265","pred":"resolved_to","subj":"11265","obj":"tmVar:rs10995190;VariantGroup:19;CorrespondingGene:22891;RS#:10995190;CorrespondingSpecies:9606"}],"text":"Ten loci have been identified by GWAS to be associated with percent mammographic density, ZNF365-rs10995190 [10, 30], 12q24-rs1265507 [31], and AREG-rs10034692, PRDM6-rs186749, ESR1-rs12665607, 8p11.23-rs7816345, LSP1-rs3817198, IGF1-rs703556, TMEM184B-rs7289126, and SGSM3-rs17001868 [10]. The ZNF365, ESR1, LSP1 and SGSM3 loci are also associated with breast cancer risk [10, 30], implicating a shared genetic basis of mammographic density and breast cancer. This is also supported by the findings of a study, which assessed a polygenic score based on mammographic density GWAS with respect to breast cancer risk [8]. Women in the top 10 % of the score had an associated 31 % increased risk of breast cancer compared to women in the bottom 10 % of the score. The locus on 12q24 on the other hand, seems not to be associated with breast cancer risk [31]. Our data indicated that associations of the SNPs identified by GWAS with mammographic density are unlikely to be modified by MHT use."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"11250","span":{"begin":167,"end":175},"obj":"SNP"},{"id":"11251","span":{"begin":149,"end":159},"obj":"SNP"},{"id":"11252","span":{"begin":253,"end":262},"obj":"SNP"},{"id":"11254","span":{"begin":234,"end":242},"obj":"SNP"},{"id":"11255","span":{"begin":182,"end":192},"obj":"SNP"},{"id":"11260","span":{"begin":202,"end":211},"obj":"SNP"},{"id":"11261","span":{"begin":218,"end":227},"obj":"SNP"},{"id":"11263","span":{"begin":124,"end":133},"obj":"SNP"},{"id":"11264","span":{"begin":274,"end":284},"obj":"SNP"},{"id":"11265","span":{"begin":97,"end":107},"obj":"SNP"},{"id":"T1","span":{"begin":167,"end":175},"obj":"SNP"},{"id":"T2","span":{"begin":149,"end":159},"obj":"SNP"},{"id":"T3","span":{"begin":253,"end":262},"obj":"SNP"},{"id":"T4","span":{"begin":234,"end":242},"obj":"SNP"},{"id":"T5","span":{"begin":182,"end":192},"obj":"SNP"},{"id":"T6","span":{"begin":202,"end":211},"obj":"SNP"},{"id":"T7","span":{"begin":218,"end":227},"obj":"SNP"},{"id":"T8","span":{"begin":124,"end":133},"obj":"SNP"},{"id":"T9","span":{"begin":274,"end":284},"obj":"SNP"},{"id":"T10","span":{"begin":97,"end":107},"obj":"SNP"}],"attributes":[{"id":"A11250","pred":"resolved_to","subj":"11250","obj":"tmVar:rs186749;VariantGroup:30;CorrespondingGene:93166;RS#:186749;CorrespondingSpecies:9606"},{"id":"A11251","pred":"resolved_to","subj":"11251","obj":"tmVar:rs10034692;VariantGroup:33;RS#:10034692"},{"id":"A11252","pred":"resolved_to","subj":"11252","obj":"tmVar:rs7289126;VariantGroup:13;CorrespondingGene:25829;RS#:7289126;CorrespondingSpecies:9606"},{"id":"A11254","pred":"resolved_to","subj":"11254","obj":"tmVar:rs703556;VariantGroup:3;RS#:703556"},{"id":"A11255","pred":"resolved_to","subj":"11255","obj":"tmVar:rs12665607;VariantGroup:34;RS#:12665607"},{"id":"A11260","pred":"resolved_to","subj":"11260","obj":"tmVar:rs7816345;VariantGroup:28;RS#:7816345"},{"id":"A11261","pred":"resolved_to","subj":"11261","obj":"tmVar:rs3817198;VariantGroup:16;CorrespondingGene:4046;RS#:3817198;CorrespondingSpecies:9606"},{"id":"A11263","pred":"resolved_to","subj":"11263","obj":"tmVar:rs1265507;VariantGroup:14;RS#:1265507"},{"id":"A11264","pred":"resolved_to","subj":"11264","obj":"tmVar:rs17001868;VariantGroup:26;CorrespondingGene:27352;RS#:17001868;CorrespondingSpecies:9606"},{"id":"A11265","pred":"resolved_to","subj":"11265","obj":"tmVar:rs10995190;VariantGroup:19;CorrespondingGene:22891;RS#:10995190;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs9358531;VariantGroup:31;RS#:9358531"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs17001868;VariantGroup:26;CorrespondingGene:27352;RS#:17001868;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs10995190;VariantGroup:19;CorrespondingGene:22891;RS#:10995190;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs7816345;VariantGroup:28;RS#:7816345"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs17202296;VariantGroup:32;CorrespondingGene:5336;RS#:17202296;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs181042206;VariantGroup:27;RS#:181042206"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs12258125;VariantGroup:0;RS#:12258125"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs7192724;VariantGroup:24;CorrespondingGene:5336;RS#:7192724;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs9358531;VariantGroup:31;RS#:9358531"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs10946545;VariantGroup:21;RS#:10946545"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs186749;VariantGroup:30;CorrespondingGene:93166;RS#:186749;CorrespondingSpecies:9606"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs7816345;VariantGroup:28;RS#:7816345"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs1265507;VariantGroup:14;RS#:1265507"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs12665607;VariantGroup:34;RS#:12665607"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs4888190;VariantGroup:9;CorrespondingGene:5336;RS#:4888190;CorrespondingSpecies:9606"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs181042206;VariantGroup:27;RS#:181042206"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs181042206;VariantGroup:27;RS#:181042206"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs12448089;VariantGroup:25;CorrespondingGene:5336;RS#:12448089;CorrespondingSpecies:9606"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs9356811;VariantGroup:8;RS#:9356811"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs1056836;VariantGroup:5;CorrespondingGene:1545;RS#:1056836;CorrespondingSpecies:9606"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs10034692;VariantGroup:33;RS#:10034692"},{"id":"A3","pred":"resolved_to","subj":"T3","obj":"tmVar:rs70355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bj":"T9","obj":"tmVar:rs10995190;VariantGroup:19;CorrespondingGene:22891;RS#:10995190;CorrespondingSpecies:9606"},{"id":"A9","pred":"resolved_to","subj":"T9","obj":"tmVar:rs9542456;VariantGroup:23;RS#:9542456"},{"id":"A9","pred":"resolved_to","subj":"T9","obj":"tmVar:rs17001868;VariantGroup:26;CorrespondingGene:27352;RS#:17001868;CorrespondingSpecies:9606"},{"id":"A10","pred":"resolved_to","subj":"T10","obj":"tmVar:rs10995190;VariantGroup:19;CorrespondingGene:22891;RS#:10995190;CorrespondingSpecies:9606"},{"id":"A10","pred":"resolved_to","subj":"T10","obj":"tmVar:rs12665607;VariantGroup:34;RS#:12665607"},{"id":"A10","pred":"resolved_to","subj":"T10","obj":"tmVar:rs703556;VariantGroup:3;RS#:703556"},{"id":"A10","pred":"resolved_to","subj":"T10","obj":"tmVar:rs181042206;VariantGroup:27;RS#:181042206"},{"id":"A10","pred":"resolved_to","subj":"T10","obj":"tmVar:rs10995190;VariantGroup:19;CorrespondingGene:22891;RS#:10995190;CorrespondingSpecies:9606"}],"text":"Ten loci have been identified by GWAS to be associated with percent mammographic density, ZNF365-rs10995190 [10, 30], 12q24-rs1265507 [31], and AREG-rs10034692, PRDM6-rs186749, ESR1-rs12665607, 8p11.23-rs7816345, LSP1-rs3817198, IGF1-rs703556, TMEM184B-rs7289126, and SGSM3-rs17001868 [10]. The ZNF365, ESR1, LSP1 and SGSM3 loci are also associated with breast cancer risk [10, 30], implicating a shared genetic basis of mammographic density and breast cancer. This is also supported by the findings of a study, which assessed a polygenic score based on mammographic density GWAS with respect to breast cancer risk [8]. Women in the top 10 % of the score had an associated 31 % increased risk of breast cancer compared to women in the bottom 10 % of the score. The locus on 12q24 on the other hand, seems not to be associated with breast cancer risk [31]. Our data indicated that associations of the SNPs identified by GWAS with mammographic density are unlikely to be modified by MHT use."}