PMC:4536239 / 2123-4299
Annnotations
TEST0
{"project":"TEST0","denotations":[{"id":"26272681-133-138-1506028","span":{"begin":144,"end":145},"obj":"[\"19289218\", \"10219926\", \"23091530\", \"16388337\", \"11554952\", \"9051330\", \"11075840\"]"},{"id":"26272681-100-105-1506029","span":{"begin":250,"end":251},"obj":"[\"19289218\"]"},{"id":"26272681-103-108-1506030","span":{"begin":253,"end":254},"obj":"[\"10219926\"]"},{"id":"26272681-106-111-1506031","span":{"begin":256,"end":257},"obj":"[\"16388337\"]"},{"id":"26272681-109-114-1506032","span":{"begin":259,"end":260},"obj":"[\"23307815\"]"},{"id":"26272681-89-94-1506033","span":{"begin":585,"end":586},"obj":"[\"23307815\"]"},{"id":"26272681-183-188-1506034","span":{"begin":772,"end":773},"obj":"[\"19289218\"]"},{"id":"26272681-186-191-1506035","span":{"begin":775,"end":776},"obj":"[\"12707434\"]"},{"id":"26272681-189-195-1506036","span":{"begin":778,"end":780},"obj":"[\"15891417\"]"},{"id":"26272681-236-242-1506037","span":{"begin":862,"end":864},"obj":"[\"19411439\"]"},{"id":"26272681-91-97-1506038","span":{"begin":1047,"end":1049},"obj":"[\"12011267\"]"},{"id":"26272681-95-101-1506039","span":{"begin":1247,"end":1249},"obj":"[\"14592341\"]"},{"id":"26272681-99-105-1506040","span":{"begin":1251,"end":1253},"obj":"[\"21795081\"]"},{"id":"26272681-141-147-1506041","span":{"begin":1397,"end":1399},"obj":"[\"14592341\"]"},{"id":"26272681-76-82-1506042","span":{"begin":1478,"end":1480},"obj":"[\"21795081\", \"19725258\", \"18274269\", \"15896230\", \"21826739\", \"22154296\", \"18973260\"]"},{"id":"26272681-89-95-1506043","span":{"begin":1575,"end":1577},"obj":"[\"22395798\", \"21538231\", \"24840006\"]"}],"text":"Background\nMigraine is a common chronic neurological disorder affecting 6–20 % of the general population, with a female-to-male ratio of 2–3:1 [1–7]. Migraine prevalence peaks from the 20s to 40s which is the most productive age in sufferers’ lives [1, 2, 4, 8]. It typically presents as recurrent headache attacks, with associated symptoms including hypersensitivity. It also causes substantial levels of disability in daily life by chronically disrupting work, personal, and family activities. The World Health Organization lists migraine as the seventh leading cause of disability [8].\nEpidemiological and clinical studies have shown that migraine is comorbid with a number of diseases including cardiovascular disorders, depression, anxiety, and other pain disorders [1, 9, 10]; and this comorbidity may increase the affected sufferer’s level of disability [11, 12]. Migraine may also share pathophysiological mechanisms with comorbid conditions [12]. However, migraine and its comorbid conditions are usually underdiagnosed and undertreated [13].\nRestless legs syndrome (RLS) is a common sensory-motor disorder with a similar female predominance. The 1-year prevalence is estimated at 2–15 %, and the approximate female-to-male ratio is 2:1 [14, 15]. The International Restless Legs Study Group (IRLSSG) has defined diagnostic criteria for RLS according to its typical clinical presentation [14]. Unlike migraine, RLS prevalence increases with age and peaks after the 50s [15–22].\nEpidemiological and clinical studies have shown an association between migraine and RLS [23–28]. However, the difference in the age-dependent prevalence of the 2 disorders suggests that the association may differ by age. However, the association of migraine and RLS in different age groups has yet not been determined. We therefore sought to investigate the association between migraine and RLS according to age groups using Korean Headache-Sleep Study data, a nationwide population-based study regarding headache and sleep disorders. A secondary outcome was to evaluate RLS prevalence according to the frequency of migraine headaches in order to corroborate the association of 2 disorders."}
2_test
{"project":"2_test","denotations":[{"id":"26272681-19289218-60560321","span":{"begin":144,"end":145},"obj":"19289218"},{"id":"26272681-10219926-60560321","span":{"begin":144,"end":145},"obj":"10219926"},{"id":"26272681-23091530-60560321","span":{"begin":144,"end":145},"obj":"23091530"},{"id":"26272681-16388337-60560321","span":{"begin":144,"end":145},"obj":"16388337"},{"id":"26272681-11554952-60560321","span":{"begin":144,"end":145},"obj":"11554952"},{"id":"26272681-9051330-60560321","span":{"begin":144,"end":145},"obj":"9051330"},{"id":"26272681-11075840-60560321","span":{"begin":144,"end":145},"obj":"11075840"},{"id":"26272681-19289218-60560322","span":{"begin":250,"end":251},"obj":"19289218"},{"id":"26272681-10219926-60560323","span":{"begin":253,"end":254},"obj":"10219926"},{"id":"26272681-16388337-60560324","span":{"begin":256,"end":257},"obj":"16388337"},{"id":"26272681-23307815-60560325","span":{"begin":259,"end":260},"obj":"23307815"},{"id":"26272681-23307815-60560326","span":{"begin":585,"end":586},"obj":"23307815"},{"id":"26272681-19289218-60560327","span":{"begin":772,"end":773},"obj":"19289218"},{"id":"26272681-12707434-60560328","span":{"begin":775,"end":776},"obj":"12707434"},{"id":"26272681-15891417-60560329","span":{"begin":778,"end":780},"obj":"15891417"},{"id":"26272681-19411439-60560330","span":{"begin":862,"end":864},"obj":"19411439"},{"id":"26272681-12011267-60560331","span":{"begin":1047,"end":1049},"obj":"12011267"},{"id":"26272681-14592341-60560332","span":{"begin":1247,"end":1249},"obj":"14592341"},{"id":"26272681-21795081-60560333","span":{"begin":1251,"end":1253},"obj":"21795081"},{"id":"26272681-14592341-60560334","span":{"begin":1397,"end":1399},"obj":"14592341"},{"id":"26272681-21795081-60560335","span":{"begin":1478,"end":1480},"obj":"21795081"},{"id":"26272681-19725258-60560335","span":{"begin":1478,"end":1480},"obj":"19725258"},{"id":"26272681-18274269-60560335","span":{"begin":1478,"end":1480},"obj":"18274269"},{"id":"26272681-15896230-60560335","span":{"begin":1478,"end":1480},"obj":"15896230"},{"id":"26272681-21826739-60560335","span":{"begin":1478,"end":1480},"obj":"21826739"},{"id":"26272681-22154296-60560335","span":{"begin":1478,"end":1480},"obj":"22154296"},{"id":"26272681-18973260-60560335","span":{"begin":1478,"end":1480},"obj":"18973260"},{"id":"26272681-22395798-60560336","span":{"begin":1575,"end":1577},"obj":"22395798"},{"id":"26272681-21538231-60560336","span":{"begin":1575,"end":1577},"obj":"21538231"},{"id":"26272681-24840006-60560336","span":{"begin":1575,"end":1577},"obj":"24840006"}],"text":"Background\nMigraine is a common chronic neurological disorder affecting 6–20 % of the general population, with a female-to-male ratio of 2–3:1 [1–7]. Migraine prevalence peaks from the 20s to 40s which is the most productive age in sufferers’ lives [1, 2, 4, 8]. It typically presents as recurrent headache attacks, with associated symptoms including hypersensitivity. It also causes substantial levels of disability in daily life by chronically disrupting work, personal, and family activities. The World Health Organization lists migraine as the seventh leading cause of disability [8].\nEpidemiological and clinical studies have shown that migraine is comorbid with a number of diseases including cardiovascular disorders, depression, anxiety, and other pain disorders [1, 9, 10]; and this comorbidity may increase the affected sufferer’s level of disability [11, 12]. Migraine may also share pathophysiological mechanisms with comorbid conditions [12]. However, migraine and its comorbid conditions are usually underdiagnosed and undertreated [13].\nRestless legs syndrome (RLS) is a common sensory-motor disorder with a similar female predominance. The 1-year prevalence is estimated at 2–15 %, and the approximate female-to-male ratio is 2:1 [14, 15]. The International Restless Legs Study Group (IRLSSG) has defined diagnostic criteria for RLS according to its typical clinical presentation [14]. Unlike migraine, RLS prevalence increases with age and peaks after the 50s [15–22].\nEpidemiological and clinical studies have shown an association between migraine and RLS [23–28]. However, the difference in the age-dependent prevalence of the 2 disorders suggests that the association may differ by age. However, the association of migraine and RLS in different age groups has yet not been determined. We therefore sought to investigate the association between migraine and RLS according to age groups using Korean Headache-Sleep Study data, a nationwide population-based study regarding headache and sleep disorders. A secondary outcome was to evaluate RLS prevalence according to the frequency of migraine headaches in order to corroborate the association of 2 disorders."}