PMC:4504005 / 31577-32284 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4504005","sourcedb":"PMC","sourceid":"4504005","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4504005","text":"The failure of the CGRP and AM peptide C-terminal residue swaps to exchange their receptor preferences (Figure 6) strongly suggests that RAMP binding site augmentation alone is insufficient to account for selectivity. Thus, the subtle differences in CLR conformation in the two structures may also be important for selectivity. RAMP-induced changes in CLR R119 side-chain conformation and/or subtle shifting of loop 2 may sufficiently alter the pocket to favor one peptide over the other. Future studies will be required to determine to what extent such allostery contributes to selectivity. Peptide selectivity determinants may also exist in portions of the receptors that were not addressed in this study.","tracks":[]}