PMC:4504005 / 30957-31576
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4504005","sourcedb":"PMC","sourceid":"4504005","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4504005","text":"Previous RAMP single swap mutant studies supported the importance of Glu at position 74/101 as a determinant for AM selectivity. RAMP1 W74E had no effect on CGRP potency but increased AM potency at the CGRP receptor (Qi et al., 2008, 2011). RAMP3 E74W decreased AM potency at the AM2 receptor, while having a negligible effect on CGRP potency (Hay et al., 2006; Qi et al., 2008, 2011). More extensive quadruple swap mutants in this study failed to exchange the pharmacological profiles, but these experiments are complicated by the different RAMP positions relative to CLR and variable RAMP effects on CLR conformation.","tracks":[{"project":"TEST0","denotations":[{"id":"25982113-99-107-8319051","span":{"begin":228,"end":232},"obj":"[\"18593822\", \"18593822\", \"18593822\"]"},{"id":"25982113-105-113-8319052","span":{"begin":234,"end":238},"obj":"[\"21402116\", \"21402116\", \"21402116\"]"},{"id":"25982113-115-123-8319053","span":{"begin":356,"end":360},"obj":"[\"16959943\", \"16959943\", \"16959943\"]"},{"id":"25982113-132-140-8319054","span":{"begin":373,"end":377},"obj":"[\"18593822\", \"18593822\", \"18593822\"]"},{"id":"25982113-138-146-8319055","span":{"begin":379,"end":383},"obj":"[\"21402116\", \"21402116\", \"21402116\"]"}],"attributes":[{"subj":"25982113-99-107-8319051","pred":"source","obj":"TEST0"},{"subj":"25982113-105-113-8319052","pred":"source","obj":"TEST0"},{"subj":"25982113-115-123-8319053","pred":"source","obj":"TEST0"},{"subj":"25982113-132-140-8319054","pred":"source","obj":"TEST0"},{"subj":"25982113-138-146-8319055","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"25982113-18593822-118216152","span":{"begin":228,"end":232},"obj":"18593822"},{"id":"25982113-18593822-118216152","span":{"begin":228,"end":232},"obj":"18593822"},{"id":"25982113-21402116-118216153","span":{"begin":234,"end":238},"obj":"21402116"},{"id":"25982113-21402116-118216153","span":{"begin":234,"end":238},"obj":"21402116"},{"id":"25982113-16959943-118216154","span":{"begin":356,"end":360},"obj":"16959943"},{"id":"25982113-16959943-118216154","span":{"begin":356,"end":360},"obj":"16959943"},{"id":"25982113-18593822-118216155","span":{"begin":373,"end":377},"obj":"18593822"},{"id":"25982113-18593822-118216155","span":{"begin":373,"end":377},"obj":"18593822"},{"id":"25982113-21402116-118216156","span":{"begin":379,"end":383},"obj":"21402116"},{"id":"25982113-21402116-118216156","span":{"begin":379,"end":383},"obj":"21402116"},{"id":"25982113-18593822-71076134","span":{"begin":234,"end":238},"obj":"18593822"},{"id":"25982113-18593822-71076134","span":{"begin":234,"end":238},"obj":"18593822"},{"id":"25982113-21402116-71076134","span":{"begin":234,"end":238},"obj":"21402116"},{"id":"25982113-21402116-71076134","span":{"begin":234,"end":238},"obj":"21402116"},{"id":"25982113-16959943-71076135","span":{"begin":379,"end":383},"obj":"16959943"},{"id":"25982113-16959943-71076135","span":{"begin":379,"end":383},"obj":"16959943"},{"id":"25982113-18593822-71076135","span":{"begin":379,"end":383},"obj":"18593822"},{"id":"25982113-18593822-71076135","span":{"begin":379,"end":383},"obj":"18593822"},{"id":"25982113-21402116-71076135","span":{"begin":379,"end":383},"obj":"21402116"},{"id":"25982113-21402116-71076135","span":{"begin":379,"end":383},"obj":"21402116"}],"attributes":[{"subj":"25982113-18593822-118216152","pred":"source","obj":"2_test"},{"subj":"25982113-18593822-118216152","pred":"source","obj":"2_test"},{"subj":"25982113-21402116-118216153","pred":"source","obj":"2_test"},{"subj":"25982113-21402116-118216153","pred":"source","obj":"2_test"},{"subj":"25982113-16959943-118216154","pred":"source","obj":"2_test"},{"subj":"25982113-16959943-118216154","pred":"source","obj":"2_test"},{"subj":"25982113-18593822-118216155","pred":"source","obj":"2_test"},{"subj":"25982113-18593822-118216155","pred":"source","obj":"2_test"},{"subj":"25982113-21402116-118216156","pred":"source","obj":"2_test"},{"subj":"25982113-21402116-118216156","pred":"source","obj":"2_test"},{"subj":"25982113-18593822-71076134","pred":"source","obj":"2_test"},{"subj":"25982113-18593822-71076134","pred":"source","obj":"2_test"},{"subj":"25982113-21402116-71076134","pred":"source","obj":"2_test"},{"subj":"25982113-21402116-71076134","pred":"source","obj":"2_test"},{"subj":"25982113-16959943-71076135","pred":"source","obj":"2_test"},{"subj":"25982113-16959943-71076135","pred":"source","obj":"2_test"},{"subj":"25982113-18593822-71076135","pred":"source","obj":"2_test"},{"subj":"25982113-18593822-71076135","pred":"source","obj":"2_test"},{"subj":"25982113-21402116-71076135","pred":"source","obj":"2_test"},{"subj":"25982113-21402116-71076135","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ec93d3","default":true},{"id":"2_test","color":"#93ecea"}]}]}}