PMC:4504005 / 15227-15845 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4504005","sourcedb":"PMC","sourceid":"4504005","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4504005","text":"Superpositions of CGRPmut-bound and ligand-free CLR:RAMP1 complexes (ter Haar et al., 2010) revealed clamp-like movement of CLR loops 3 and 4 upon CGRPmut binding, presumably mediated by the CGRPmut T30-CLR D94 interaction and β-turn contacts with CLR loop 4 including the CGRPmut F35-CLR S117 interaction (Figures 3A and 3B). CLR R119 shifts to accommodate the peptide and RAMP1 F83 rotates away from CLR loop 4 (Figure 3B). The RAMP1 position relative to CLR varies in the structures (Figure 3A), but the positions of the α2-α3 loop and W84, which contacts CGRPmut F37, remain relatively similar (Figures 3A and 3B).","tracks":[{"project":"TEST0","denotations":[{"id":"25982113-87-95-8319020","span":{"begin":86,"end":90},"obj":"[\"20826335\", \"20826335\", \"20826335\"]"}],"attributes":[{"subj":"25982113-87-95-8319020","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"25982113-20826335-118216122","span":{"begin":86,"end":90},"obj":"20826335"},{"id":"25982113-20826335-118216122","span":{"begin":86,"end":90},"obj":"20826335"},{"id":"25982113-20826335-71076117","span":{"begin":86,"end":90},"obj":"20826335"},{"id":"25982113-20826335-71076117","span":{"begin":86,"end":90},"obj":"20826335"}],"attributes":[{"subj":"25982113-20826335-118216122","pred":"source","obj":"2_test"},{"subj":"25982113-20826335-118216122","pred":"source","obj":"2_test"},{"subj":"25982113-20826335-71076117","pred":"source","obj":"2_test"},{"subj":"25982113-20826335-71076117","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#93ece7","default":true},{"id":"2_test","color":"#eccd93"}]}]}}