PMC:4504005 / 1289-1634 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4504005","sourcedb":"PMC","sourceid":"4504005","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4504005","text":"• Crystal structures reveal how CGRP and AM peptides bind their heterodimeric receptors\n• CGRP and AM occupy a shared binding site on CLR with minimal contact to the RAMPs\n• Peptide binding modes were confirmed for intact receptors in cells by mutagenesis\n• Peptide selectivity arises from RAMP-specific contacts and subtle alteration of CLR","divisions":[{"label":"label","span":{"begin":0,"end":1}},{"label":"p","span":{"begin":3,"end":88}},{"label":"label","span":{"begin":89,"end":90}},{"label":"p","span":{"begin":92,"end":173}},{"label":"label","span":{"begin":174,"end":175}},{"label":"p","span":{"begin":177,"end":258}},{"label":"label","span":{"begin":259,"end":260}}],"tracks":[]}