PMC:4504005 / 1278-1634 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4504005","sourcedb":"PMC","sourceid":"4504005","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4504005","text":"Highlights\n• Crystal structures reveal how CGRP and AM peptides bind their heterodimeric receptors\n• CGRP and AM occupy a shared binding site on CLR with minimal contact to the RAMPs\n• Peptide binding modes were confirmed for intact receptors in cells by mutagenesis\n• Peptide selectivity arises from RAMP-specific contacts and subtle alteration of CLR","divisions":[{"label":"title","span":{"begin":0,"end":10}},{"label":"label","span":{"begin":11,"end":12}},{"label":"p","span":{"begin":14,"end":99}},{"label":"label","span":{"begin":100,"end":101}},{"label":"p","span":{"begin":103,"end":184}},{"label":"label","span":{"begin":185,"end":186}},{"label":"p","span":{"begin":188,"end":269}},{"label":"label","span":{"begin":270,"end":271}}],"tracks":[]}