PMC:4503824 / 34567-35453 JSONTXT

{"project":"2_test","denotations":[{"id":"25498576-18090038-43267833","span":{"begin":200,"end":204},"obj":"18090038"},{"id":"25498576-22474485-43267834","span":{"begin":880,"end":884},"obj":"22474485"}],"text":"The adaptive immune response is unequivocally essential for host eradication of C. neoformans with the T cell defects seen in, and so strongly associated with, HIV/AIDS patients (Jarvis and Harrison, 2007). There are several types of T lymphocytes (T cells) involved in the host response to C. neoformans, including CD4+, CD8+ and natural killer T (NKT) cells. In addition to T cells, natural killer (NK) cells are lymphoid cells that directly interact with cryptococci. CD4+ T cells are key in orchestrating the type of immune response that results from immune challenge. Naïve CD4+ T cells are activated and differentiate into different subsets, such as Th1, Th2 and Th17, due to the cytokines present. Furthermore, once active CD4+ T cells are able to help B cells, macrophages and CD8+ T cells, to produce antibodies, activate and proliferate respectively (Luckheeram et al., 2012)."}