PMC:4503824 / 33506-34524 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4503824","sourcedb":"PMC","sourceid":"4503824","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4503824","text":"Antibodies have been shown to have a protective effect in lethally infected mice (Fleuridor et al., 1998; Mukherjee et al., 1992), showing that antibodies are effective as opsonins for C. neoformans. A mouse model deficient in secreted IgM showed increased death and fungal burden in the blood and brain. Mice with secreted IgM adopted a Th1 profile early during infection and had higher levels of phagocytosis (Marks and Pirofski, 2010). Furthermore, a B1 B cell deficient murine model showed increased fungal burden and decreased alveolar macrophage uptake (through decreased IgM) (Szymczak et al., 2013). This provides an association between B cell responses, and the effector function of phagocytes using antibody for phagocytosis, and suggests that there is requirement for antibody in the normal clearance of cryptococci. Therapy targeting B cell and antibody responses is a potentially fruitful area but further work is needed to understand the mechanisms involved and what defects are present in human disease.","tracks":[{"project":"2_test","denotations":[{"id":"25498576-9806064-43267831","span":{"begin":124,"end":128},"obj":"9806064"},{"id":"25498576-1398966-43267831","span":{"begin":124,"end":128},"obj":"1398966"},{"id":"25498576-20404271-43267832","span":{"begin":432,"end":436},"obj":"20404271"}],"attributes":[{"subj":"25498576-9806064-43267831","pred":"source","obj":"2_test"},{"subj":"25498576-1398966-43267831","pred":"source","obj":"2_test"},{"subj":"25498576-20404271-43267832","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ecd093","default":true}]}]}}