PMC:4503824 / 20624-21502
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4503824","sourcedb":"PMC","sourceid":"4503824","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4503824","text":"Cryptococci can escape macrophages by lysis or through expulsion. The mechanism of lysis is unknown. In some cases this appears to result from intracellular replication leading to large numbers of intraphagosomal cryptococci causing rupture of the host cell membrane (Tucker and Casadevall, 2002). Several studies have identified that the cryptococcal phagosome is permeabilised, but by two different mechanisms: Pores to the cytoplasm (Tucker and Casadevall, 2002) and extracellular phagosome emptying (Carnell et al., 2011; Johnston and May, 2010). Expulsion of cryptococci is described as a non-lytic escape from macrophages via an actin independent exocytosis (Alvarez and Casadevall, 2006; Johnston and May, 2010; Ma et al., 2006). Cryptococci leave the macrophage without causing damage to the host cell. Again as with lateral transfer the ultimate beneficiary is unknown.","tracks":[{"project":"2_test","denotations":[{"id":"25498576-11880650-43267795","span":{"begin":291,"end":295},"obj":"11880650"},{"id":"25498576-11880650-43267796","span":{"begin":460,"end":464},"obj":"11880650"},{"id":"25498576-21606208-43267797","span":{"begin":544,"end":548},"obj":"21606208"},{"id":"25498576-20714349-43267797","span":{"begin":544,"end":548},"obj":"20714349"},{"id":"25498576-17084702-43267798","span":{"begin":730,"end":734},"obj":"17084702"},{"id":"25498576-20714349-43267798","span":{"begin":730,"end":734},"obj":"20714349"},{"id":"25498576-17084701-43267798","span":{"begin":730,"end":734},"obj":"17084701"}],"attributes":[{"subj":"25498576-11880650-43267795","pred":"source","obj":"2_test"},{"subj":"25498576-11880650-43267796","pred":"source","obj":"2_test"},{"subj":"25498576-21606208-43267797","pred":"source","obj":"2_test"},{"subj":"25498576-20714349-43267797","pred":"source","obj":"2_test"},{"subj":"25498576-17084702-43267798","pred":"source","obj":"2_test"},{"subj":"25498576-20714349-43267798","pred":"source","obj":"2_test"},{"subj":"25498576-17084701-43267798","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ecc093","default":true}]}]}}