PMC:4503824 / 15791-16887 JSONTXT

{"project":"2_test","denotations":[{"id":"25498576-15481139-43267781","span":{"begin":174,"end":178},"obj":"15481139"},{"id":"25498576-23733871-43267782","span":{"begin":372,"end":376},"obj":"23733871"},{"id":"25498576-19237602-43267783","span":{"begin":639,"end":643},"obj":"19237602"}],"text":"Recognition via scavenger receptor A (SR-A) (classically a receptor for low-density lipoprotein but which also interacts with a number of pathogens (Mukhopadhyay and Gordon, 2004)) appears to promote a Th2 immune profile. The SR-A deficient mouse demonstrated a better host response in terms of fungal clearance coupled with decreased IL4 and IL13 production (Qiu et al., 2013). In contrast, the class B scavenger receptors CD36 and SCARF may be a requirement for pro inflammatory Il-1beta, as the absence of CD36 resulted in a modest reduction in survival in the susceptible C57BL/6 stain after acute intravenous infection (Means et al., 2009). These two studies represent the best evidence that the specific phagocytic receptor involved in uptake of cryptococci into macrophages may directly regulate immune signalling and therefore the outcome of infection. This is, potentially, a highly significant area of Cryptococcus research but there are still fundamental gaps in our understanding, for example, a direct demonstration that scavenger receptors mediate the uptake of cryptococci in vivo."}