PMC:4503824 / 10767-11824 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4503824","sourcedb":"PMC","sourceid":"4503824","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4503824","text":"Macrophage control of cryptococci is essential early in infection with depletion of AMs in the lungs of rats (a normally resistant host) leading to high fungal burden and dissemination following intratracheal infection (Shao et al., 2005). Interestingly, it has been recently demonstrated that phagocytosis in vitro can be associated with fungal burden in a patient cohort, where increased uptake by macrophages was associated with poor prognosis (Sabiiti et al., seminar presentation 9.5, ICCC9; Sabiiti et al., 2014). However, both the mechanism governing the difference in phagocytic uptake of these strains, and the point during infection where the phagocytosis phenotype is critical in human infection, are yet to be identified. Furthermore, in mice deficient in macrophages and DCs there were increased numbers of PMNs and B cells in response to cryptococcal infection. Neutrophils and B cells alone were unable to control the infection and their continued presence and activation is potentially highly damaging to the host (Osterholzer et al., 2009).","tracks":[{"project":"2_test","denotations":[{"id":"25498576-16116215-43267772","span":{"begin":233,"end":237},"obj":"16116215"},{"id":"25498576-24743149-43267773","span":{"begin":513,"end":517},"obj":"24743149"},{"id":"25498576-19564388-43267774","span":{"begin":1051,"end":1055},"obj":"19564388"}],"attributes":[{"subj":"25498576-16116215-43267772","pred":"source","obj":"2_test"},{"subj":"25498576-24743149-43267773","pred":"source","obj":"2_test"},{"subj":"25498576-19564388-43267774","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#9e93ec","default":true}]}]}}