PMC:4502373 / 46476-47600 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4502373","sourcedb":"PMC","sourceid":"4502373","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4502373","text":"Conclusion\nThis study demonstrates an approach to detect signatures of selection for complex traits. We successfully used CSS in the analysis of the genetic architecture of a complex polygenic trait using multibreed panels. Our results demonstrated the localization of genomic regions harboring candidate genes of known effect related to body development, skeletal growth, and stature in cattle. We identified 26 regions with strong signatures of selection for stature, of which 12 regions contained known genes linked to height or stature and 9 could be considered novel in European and African Bos taurus. These results should be of interest for future investigations to characterize causal variants to explain their functional role in the diversity of bovine stature. Implementation of new tools, such as CSS, can resolve the selected genomic regions underlying the complex traits in livestock species. We suggest that the application of genome-wide selection scans and GWAS using larger resource populations with phenotypic information can further improve the fine-mapping of causal mutations controlling complex traits.","divisions":[{"label":"title","span":{"begin":0,"end":10}}],"tracks":[]}