PMC:4502373 / 41064-41914 JSONTXT

{"project":"2_test","denotations":[{"id":"25931611-21516082-43349836","span":{"begin":275,"end":279},"obj":"21516082"},{"id":"25931611-21194676-43349837","span":{"begin":616,"end":620},"obj":"21194676"},{"id":"25931611-20189936-43349838","span":{"begin":665,"end":669},"obj":"20189936"},{"id":"25931611-18391951-43349839","span":{"begin":752,"end":756},"obj":"18391951"}],"text":"There can be some advantages of limiting body size in smaller breeds, for instance, in relation to ease of calving or resource-limited production systems. As noted above, early domestication favored selective breeding to reduce body size for ease of management (Karim et al. 2011; Ajmone-Marsan et al. 2010). With very few exceptions (e.g., Dexter), recent history of European Bos taurus breeds do not document selective breeding for smaller size. Interestingly, 60% of all significant regions can be considered novel in the small cohort and harbor stature-associated genes, namely PKN2 at region 3 (Lanktree et al. 2011), ATP5G2 and ATF7 at region 5 (Okada et al. 2010), and CAMLG, DDX46, TXNDC15, CATSPER3, and PITX1 at region 7 (Gudbjartsson et al. 2008). The functional role of these candidate genes in relation to stature is not well-documented."}