PMC:4502373 / 34586-35502 JSONTXT

{"project":"2_test","denotations":[{"id":"25931611-22899652-43349795","span":{"begin":191,"end":195},"obj":"22899652"},{"id":"25931611-22497248-43349796","span":{"begin":734,"end":738},"obj":"22497248"}],"text":"Use of multibreed cohorts has increased the discovery of trait-specific regions because of shared linkage disequilibrium between the causal mutations and neighboring SNPs (Kemper and Goddard 2012) arising from long-term historical selection. Contrasting patterns of genomic variation at the putative regions under selection across groups increases the likelihood of capturing the signatures of selection linked to stature. In our approach, signals of selection are amplified at candidate regions across breeds within groups, whereas background noise (false-positive signals) is reduced in the rest of the genome. Such noise is usually expected from the demographic history of breed formation and random genetic drift (Seichter et al. 2012). Overall, application of the CSS method combined with grouping breeds according to their wither height identified candidate regions in the bovine genome for this complex trait."}