PMC:4502372 / 42070-42623 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4502372","sourcedb":"PMC","sourceid":"4502372","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4502372","text":"The SEACAT and the Iml1 complex are functionally conserved in humans. To date, somatic mutations in the human IML1/SEA1 homolog, DEPDC5, have been found mutated in cancers (Bar-Peled et al. 2013) and germline mutations have been found in familial autosomal-dominant epilepsy and focal malformations of cortical development (Dibbens et al. 2013; Ishida et al. 2013; Martin et al. 2013; Picard et al. 2014; D’Gama et al. 2015). It is anticipated that homologs of other members of the SEA complex, including SEA3, will also prove to be clinically relevant.","tracks":[{"project":"2_test","denotations":[{"id":"25943524-23723238-43313312","span":{"begin":190,"end":194},"obj":"23723238"},{"id":"25943524-23542697-43313313","span":{"begin":339,"end":343},"obj":"23542697"},{"id":"25943524-23542701-43313314","span":{"begin":359,"end":363},"obj":"23542701"},{"id":"25943524-24814846-43313315","span":{"begin":399,"end":403},"obj":"24814846"},{"id":"25943524-25599672-43313316","span":{"begin":419,"end":423},"obj":"25599672"}],"attributes":[{"subj":"25943524-23723238-43313312","pred":"source","obj":"2_test"},{"subj":"25943524-23542697-43313313","pred":"source","obj":"2_test"},{"subj":"25943524-23542701-43313314","pred":"source","obj":"2_test"},{"subj":"25943524-24814846-43313315","pred":"source","obj":"2_test"},{"subj":"25943524-25599672-43313316","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ecd493","default":true}]}]}}