PMC:4502372 / 3016-3988 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4502372","sourcedb":"PMC","sourceid":"4502372","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4502372","text":"Further analysis of the SEA complex in S. cerevisiae revealed two epistatic groups, the Iml1 complex (a.k.a. SEACIT) and SEACAT, which segregate and function like GATOR1 and GATOR2 in humans; SEACAT (Sea2, Sea3, Sea4, Seh1, and Sec13) negatively regulates the Iml1 complex/SEACIT (Iml1, Npr2, and Npr3), which negatively regulates TORC1 signaling (Figure 1A) (Panchaud et al. 2013a,b). Importantly, although there are two Tor complexes in S. cerevisiae, TORC1 and TORC2, each of which regulate a distinct set of cellular functions, (Loewith et al. 2002), the SEA complex has only been established as a regulator of TORC1. Analysis of TORC1 signaling under conditions of amino acid deprivation revealed that Sea2, Sea3, and Sea4 act redundantly to attenuate the inhibitory properties of the Iml1 complex (Panchaud et al. 2013a). Whether there are conditions under which an individual member of the SEACAT complex functions alone to regulate TORC1 signaling remains unknown.","tracks":[]}