PMC:4502371 / 29115-29675 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4502371","sourcedb":"PMC","sourceid":"4502371","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4502371","text":"In this study, we isolated a new mua-3 mutation that shows defects in connective tissue-like tissues that lead to death specifically during the L4 molt in a temperature-sensitive manner. The sequence homology and the similar phenotypes we and others found in mua-3 mutants suggest that MUA-3 is a homolog of FBN1 and that the role of fibrillin genes in C. elegans and humans could be conserved. mua-3(uy19) lethality that is specific during the L4 molt (but not in other molts) could suggest that the mechanical strain may be most stressful during the L4 molt.","tracks":[]}