PMC:4502371 / 28483-29102 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4502371","sourcedb":"PMC","sourceid":"4502371","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4502371","text":"dpy-17 encodes a cuticle collagen required for normal body morphology (Novelli et al. 2006). Genetic studies show that a gain-of-function mutation of dpy-17 suppresses phenotypes of dpy-31 mutations, indicating a genetic interaction between the two. dpy-31 encodes a homolog of the human bone morphogenic protein-1 (Novelli et al. 2004). The human bone morphogenic protein-1 is a tolloid-like gene whose proteolytic activity is required for TGFβ activation (Ge and Greenspan 2006). Our screen results suggest a potential link between MUA-3-associated and TGFβ-associated molecules such as DPY-31 via DPY-17 (Figure 6C).","tracks":[{"project":"2_test","denotations":[{"id":"25917920-16452136-43299639","span":{"begin":86,"end":90},"obj":"16452136"},{"id":"25917920-15579684-43299640","span":{"begin":331,"end":335},"obj":"15579684"},{"id":"25917920-17015622-43299641","span":{"begin":475,"end":479},"obj":"17015622"}],"attributes":[{"subj":"25917920-16452136-43299639","pred":"source","obj":"2_test"},{"subj":"25917920-15579684-43299640","pred":"source","obj":"2_test"},{"subj":"25917920-17015622-43299641","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93d1","default":true}]}]}}