PMC:4502368 / 53313-54493 JSONTXT

{"project":"2_test","denotations":[{"id":"25911227-24567748-43383419","span":{"begin":17,"end":21},"obj":"24567748"},{"id":"25911227-24567748-43383420","span":{"begin":275,"end":279},"obj":"24567748"},{"id":"25911227-22957178-43383421","span":{"begin":405,"end":409},"obj":"22957178"}],"text":"Jeffries et al. (2014) study of gene expression in the gill tissue of chronically heat-stressed adult pink and sockeye salmon found the largest number of genes in common with the current study. In addition to chaperone genes in the HSP90 and HSP70 families, Jeffries et al. (2014) found inflammatory regulators involved with NF-κB activity and other inflammatory/immune regulatory genes. Jeffries et al. (2012) found that the increase in ODC1 and CEBPB was the largest in moribund sockeye salmon, both of which were also upregulated in this study. They also identified several late-stage caspases involved in apoptosis, as did this study. Regardless of the difference in species, life stage, and duration of temperature exposure, many of the same functional pathways were upregulated in both the current and above studies, namely protein stabilization/degradation, apoptosis, and immunity/inflammation. In addition to these similarities, this study demonstrates an association of thermal stress in juvenile Chinook salmon with expression of some genes not previously linked to heat stress in salmonids, including cytoskeletal genes CCT4, CCT5, TBCB, AIF1L, SYNPO, CNN2 and PDLIM1."}