PMC:4502368 / 46609-47792
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4502368","sourcedb":"PMC","sourceid":"4502368","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4502368","text":"Cell signaling\nCell signaling genes ORMDL3, PAK4, TRIB3, SRY4, DUSP1, DUSP2, NCK2, and PTK6 that were upregulated at 25° (two-fold to 21-fold) largely function in the UPR, immunity or inflammation, the general stress response, and promotion or protection from apoptosis. ORMDL3 participates in calcium signaling in the endoplasmic reticulum and is associated with increased strength of the UPR (Cantero-Recasens et al. 2009). PAK4 protects the cell from apoptosis and reduces the effect of caspase 8 (Gnesutta et al. 2001; Gnesutta and Minden 2003). TRIB3 is upregulated by stressful stimuli and, along with SRY4, regulates MAPK cell signaling (Kiss-Toth et al. 2004; Ord and Ord 2005; Cabrita and Christofori 2008). DUSP1 and DUSP2 encode serine/threonine kinases that are important for intracellular signaling and participate in inflammatory and immune signaling (Huang and Tan 2012). NCK2 is involved in intracellular signaling in both stress and normal conditions (Tu et al. 1998), as is PTK6. PTK6 is involved in DNA damage–induced apoptosis (Brauer and Tyner 2010). Much of the alteration in cell signaling genes relates directly to some aspect of the cellular stress response.","divisions":[{"label":"title","span":{"begin":0,"end":14}}],"tracks":[{"project":"2_test","denotations":[{"id":"25911227-11278822-43383390","span":{"begin":517,"end":521},"obj":"11278822"},{"id":"25911227-14560027-43383391","span":{"begin":543,"end":547},"obj":"14560027"},{"id":"25911227-15299019-43383392","span":{"begin":662,"end":666},"obj":"15299019"},{"id":"25911227-15781252-43383393","span":{"begin":680,"end":684},"obj":"15781252"},{"id":"25911227-18219583-43383394","span":{"begin":710,"end":714},"obj":"18219583"},{"id":"25911227-22769588-43383395","span":{"begin":880,"end":884},"obj":"22769588"},{"id":"25911227-9843575-43383396","span":{"begin":979,"end":983},"obj":"9843575"}],"attributes":[{"subj":"25911227-11278822-43383390","pred":"source","obj":"2_test"},{"subj":"25911227-14560027-43383391","pred":"source","obj":"2_test"},{"subj":"25911227-15299019-43383392","pred":"source","obj":"2_test"},{"subj":"25911227-15781252-43383393","pred":"source","obj":"2_test"},{"subj":"25911227-18219583-43383394","pred":"source","obj":"2_test"},{"subj":"25911227-22769588-43383395","pred":"source","obj":"2_test"},{"subj":"25911227-9843575-43383396","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecd2","default":true}]}]}}