PMC:4502368 / 43979-44670 JSONTXT

{"project":"2_test","denotations":[{"id":"25911227-17606386-43383376","span":{"begin":325,"end":329},"obj":"17606386"},{"id":"25911227-8622660-43383377","span":{"begin":438,"end":442},"obj":"8622660"},{"id":"25911227-24581496-43383378","span":{"begin":596,"end":600},"obj":"24581496"},{"id":"25911227-9732876-43383379","span":{"begin":685,"end":689},"obj":"9732876"}],"text":"Unsurprisingly, expression of many regulators of transcription and translation was altered. Several transcription factors relating to stress, UPR, apoptosis, and inflammation were upregulated in the 21° and 25° groups. ATF5, for instance, is a transcription factor that is implicated in production of small HSPs (Wang et al. 2007). ATF3 is similarly known to be a stress response gene that is induced by physiological stress (Chen et al. 1996). Upregulated EP300 stabilizes transcription factor HSF-1, which in turn regulates expression of heat shock proteins and chaperones (Raychaudhuri et al. 2014). FOS can function with the JUN/AP1 complex to regulate transcription (Zhang et al. 1998)."}