PMC:4502368 / 21826-23220 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4502368","sourcedb":"PMC","sourceid":"4502368","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4502368","text":"Under thermal stress, especially at higher temperatures, normal cellular functions are suspended as the organism attempts to cope with the current stress (Parsell and Lindquist 1993; Kültz 2005; Logan and Somero 2011). Twenty-six KEGG pathways were identified for which at least two enzymes were upregulated (Table 5). Based on GO terms and protein functional information obtained from the UniProt database, 12 manually curated functional gene groups were identified among the results: (1) protein folding/rescue; (2) protein degradation; (3) cell death; (4) oxidative stress; (5) metabolism; (6) inflammation/immunity; (7) transcription/translation; (8) ion transport; (9) cell cycle/growth; (10) cell signaling; (11) cellular trafficking; and (12) structure/cytoskeleton. These functional categories represent a picture of biologically relevant changes that take place in response to acute thermal exposure in Chinook salmon. We provide interpretation of the gene function based on GO terms, the UniProt database, and published literature, although there may be additional functional roles of the identified genes that are not outlined here. We focused our discussion on gene functions to those that have been identified in fish or shown to be related to thermal stress. Likewise, we emphasize the roles of upregulated transcripts, although relevant downregulated genes also exist (Table S1).","tracks":[{"project":"2_test","denotations":[{"id":"25911227-8122909-43383296","span":{"begin":177,"end":181},"obj":"8122909"},{"id":"25911227-15709958-43383297","span":{"begin":189,"end":193},"obj":"15709958"}],"attributes":[{"subj":"25911227-8122909-43383296","pred":"source","obj":"2_test"},{"subj":"25911227-15709958-43383297","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93eca9","default":true}]}]}}