PMC:4429232 / 38411-39781 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4429232","sourcedb":"PMC","sourceid":"4429232","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4429232","text":"In this perspective, in the last years different authors have analyzed the pattern of expression of the sauropsid orthologs of genes expressed in specific neocortical layers (Nomura et al., 2008, 2013; Dugas-Ford et al., 2012; Suzuki et al., 2012; Chen et al., 2013; Suzuki and Hirata, 2014). The drawback of this approach is that the few individual genes that have been analyzed are expressed by multiple cell types not only in the neocortex but also in other brain regions (Medina et al., 2013). Moreover, the layer specificity of some of the markers of upper layer cells have been disputed (Dugas-Ford et al., 2012). Nonetheless, from these studies a general pattern emerged in which the orthologs of DL markers tend to be expressed more medially than those of the UL. These latter genes are mostly expressed in LP derivatives such as the mesopallium/pallial thickening or the olfactory cortex (Dugas-Ford et al., 2012; Suzuki and Hirata, 2013; Nomura et al., 2014). Since clonal analyses in chick indicate that pallial neurons expressing the orthologs of DL and UL markers are produced by spatially segregated progenitors (Suzuki et al., 2012), these observations are consistent with the hypothesis that the evolution of the mammalian neocortex involved a spatial to temporal patterning switch (Dugas-Ford et al., 2012; Suzuki and Hirata, 2013; Nomura et al., 2014).","tracks":[{"project":"0_colil","denotations":[{"id":"26029038-18197264-565903","span":{"begin":190,"end":194},"obj":"18197264"},{"id":"26029038-23884180-565904","span":{"begin":196,"end":200},"obj":"23884180"},{"id":"26029038-23027930-565905","span":{"begin":221,"end":225},"obj":"23027930"},{"id":"26029038-22424929-565906","span":{"begin":242,"end":246},"obj":"22424929"},{"id":"26029038-23818174-565907","span":{"begin":261,"end":265},"obj":"23818174"},{"id":"26029038-24778607-565908","span":{"begin":286,"end":290},"obj":"24778607"},{"id":"26029038-23549106-565909","span":{"begin":491,"end":495},"obj":"23549106"},{"id":"26029038-23027930-565910","span":{"begin":613,"end":617},"obj":"23027930"},{"id":"26029038-23027930-565911","span":{"begin":917,"end":921},"obj":"23027930"},{"id":"26029038-23230908-565912","span":{"begin":942,"end":946},"obj":"23230908"},{"id":"26029038-24671134-565913","span":{"begin":963,"end":967},"obj":"24671134"},{"id":"26029038-22424929-565914","span":{"begin":1142,"end":1146},"obj":"22424929"},{"id":"26029038-23027930-565915","span":{"begin":1318,"end":1322},"obj":"23027930"},{"id":"26029038-23230908-565916","span":{"begin":1343,"end":1347},"obj":"23230908"},{"id":"26029038-24671134-565917","span":{"begin":1364,"end":1368},"obj":"24671134"}],"attributes":[{"subj":"26029038-18197264-565903","pred":"source","obj":"0_colil"},{"subj":"26029038-23884180-565904","pred":"source","obj":"0_colil"},{"subj":"26029038-23027930-565905","pred":"source","obj":"0_colil"},{"subj":"26029038-22424929-565906","pred":"source","obj":"0_colil"},{"subj":"26029038-23818174-565907","pred":"source","obj":"0_colil"},{"subj":"26029038-24778607-565908","pred":"source","obj":"0_colil"},{"subj":"26029038-23549106-565909","pred":"source","obj":"0_colil"},{"subj":"26029038-23027930-565910","pred":"source","obj":"0_colil"},{"subj":"26029038-23027930-565911","pred":"source","obj":"0_colil"},{"subj":"26029038-23230908-565912","pred":"source","obj":"0_colil"},{"subj":"26029038-24671134-565913","pred":"source","obj":"0_colil"},{"subj":"26029038-22424929-565914","pred":"source","obj":"0_colil"},{"subj":"26029038-23027930-565915","pred":"source","obj":"0_colil"},{"subj":"26029038-23230908-565916","pred":"source","obj":"0_colil"},{"subj":"26029038-24671134-565917","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"26029038-18197264-38462809","span":{"begin":190,"end":194},"obj":"18197264"},{"id":"26029038-23884180-38462810","span":{"begin":196,"end":200},"obj":"23884180"},{"id":"26029038-23027930-38462811","span":{"begin":221,"end":225},"obj":"23027930"},{"id":"26029038-22424929-38462812","span":{"begin":242,"end":246},"obj":"22424929"},{"id":"26029038-23818174-38462813","span":{"begin":261,"end":265},"obj":"23818174"},{"id":"26029038-24778607-38462814","span":{"begin":286,"end":290},"obj":"24778607"},{"id":"26029038-23549106-38462815","span":{"begin":491,"end":495},"obj":"23549106"},{"id":"26029038-23027930-38462816","span":{"begin":613,"end":617},"obj":"23027930"},{"id":"26029038-23027930-38462817","span":{"begin":917,"end":921},"obj":"23027930"},{"id":"26029038-23230908-38462818","span":{"begin":942,"end":946},"obj":"23230908"},{"id":"26029038-24671134-38462819","span":{"begin":963,"end":967},"obj":"24671134"},{"id":"26029038-22424929-38462820","span":{"begin":1142,"end":1146},"obj":"22424929"},{"id":"26029038-23027930-38462821","span":{"begin":1318,"end":1322},"obj":"23027930"},{"id":"26029038-23230908-38462822","span":{"begin":1343,"end":1347},"obj":"23230908"},{"id":"26029038-24671134-38462823","span":{"begin":1364,"end":1368},"obj":"24671134"}],"attributes":[{"subj":"26029038-18197264-38462809","pred":"source","obj":"2_test"},{"subj":"26029038-23884180-38462810","pred":"source","obj":"2_test"},{"subj":"26029038-23027930-38462811","pred":"source","obj":"2_test"},{"subj":"26029038-22424929-38462812","pred":"source","obj":"2_test"},{"subj":"26029038-23818174-38462813","pred":"source","obj":"2_test"},{"subj":"26029038-24778607-38462814","pred":"source","obj":"2_test"},{"subj":"26029038-23549106-38462815","pred":"source","obj":"2_test"},{"subj":"26029038-23027930-38462816","pred":"source","obj":"2_test"},{"subj":"26029038-23027930-38462817","pred":"source","obj":"2_test"},{"subj":"26029038-23230908-38462818","pred":"source","obj":"2_test"},{"subj":"26029038-24671134-38462819","pred":"source","obj":"2_test"},{"subj":"26029038-22424929-38462820","pred":"source","obj":"2_test"},{"subj":"26029038-23027930-38462821","pred":"source","obj":"2_test"},{"subj":"26029038-23230908-38462822","pred":"source","obj":"2_test"},{"subj":"26029038-24671134-38462823","pred":"source","obj":"2_test"}]}],"config":{"attribute 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