PMC:4428493 / 39658-41242 JSONTXT

{"project":"0_colil","denotations":[{"id":"25988110-23867558-908739","span":{"begin":876,"end":878},"obj":"23867558"},{"id":"25988110-24335762-908740","span":{"begin":1579,"end":1582},"obj":"24335762"}],"text":"This review is limited by the heterogeneity of study variables used across the reviewed articles, making direct comparisons between studies difficult. As a limited number of studies met the inclusion criteria for the meta-analysis comparing pre- and post-weight loss activation changes, a single exploratory meta-analysis was undertaken combining both surgical and behavioral weight-loss interventions. The pooling of different methods of weight loss could impact the findings of the meta-analysis. However, this data provides insight into neural activation following weight loss, regardless of modality, which needs to be substantiated in future research when more studies have been published in this area. The quality of reporting BMI was inconsistent across studies, with participant groups containing BMI ranges that corresponded with more than one of the WHO categories (54). This could affect possible relationships between fMRI outcomes and weight status. As BMI can be affected by numerous factors including muscle mass, adiposity or body fat percentage is a more reflective measure of obesity assessment and should be considered for use in future studies. The majority of reviewed articles studied adult female participants exclusively, potentially limiting the generalizability of the study findings to other population groups. Finally, the broad age range of the study participants could be a potential limitation of the review, with previous studies showing age-related changes in neural activity including reduced sensitivity of brain areas associated with satiety (109)."}

{"project":"2_test","denotations":[{"id":"25988110-23867558-38724666","span":{"begin":876,"end":878},"obj":"23867558"},{"id":"25988110-24335762-38724667","span":{"begin":1579,"end":1582},"obj":"24335762"}],"text":"This review is limited by the heterogeneity of study variables used across the reviewed articles, making direct comparisons between studies difficult. As a limited number of studies met the inclusion criteria for the meta-analysis comparing pre- and post-weight loss activation changes, a single exploratory meta-analysis was undertaken combining both surgical and behavioral weight-loss interventions. The pooling of different methods of weight loss could impact the findings of the meta-analysis. However, this data provides insight into neural activation following weight loss, regardless of modality, which needs to be substantiated in future research when more studies have been published in this area. The quality of reporting BMI was inconsistent across studies, with participant groups containing BMI ranges that corresponded with more than one of the WHO categories (54). This could affect possible relationships between fMRI outcomes and weight status. As BMI can be affected by numerous factors including muscle mass, adiposity or body fat percentage is a more reflective measure of obesity assessment and should be considered for use in future studies. The majority of reviewed articles studied adult female participants exclusively, potentially limiting the generalizability of the study findings to other population groups. Finally, the broad age range of the study participants could be a potential limitation of the review, with previous studies showing age-related changes in neural activity including reduced sensitivity of brain areas associated with satiety (109)."}