PMC:4428493 / 1828-2911
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4428493","sourcedb":"PMC","sourceid":"4428493","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4428493","text":"The prevalence of obesity is increasing rapidly (1) with 33.6% of people in the United States classified as overweight and 34.9% classified as obese in 2011–2012 (2). Obesity increases the risk for a variety of lifestyle diseases including cardiovascular disease, hypertension, diabetes, and some cancers (3), as well as reduced quality of life (4). To minimize the substantial economic and health burden of obesity, numerous approaches have been used to target overweight and obese individuals to facilitate weight loss, including lifestyle and surgical interventions (5). Weight-loss interventions focusing on behavioral changes such as dietary modifications and increased physical activity are commonly used; however, these have demonstrated variable effects on weight loss and its long-term maintenance (6). Recently, there has been interest in the possible role that neural mechanisms play in the development and maintenance of obesity. In addition, increasing attention has been given to investigating the impact these neural mechanisms may have on weight loss and maintenance.","tracks":[{"project":"0_colil","denotations":[{"id":"25988110-24880830-908325","span":{"begin":49,"end":50},"obj":"24880830"},{"id":"25988110-24570244-908326","span":{"begin":163,"end":164},"obj":"24570244"},{"id":"25988110-16733522-908327","span":{"begin":346,"end":347},"obj":"16733522"},{"id":"25988110-19370590-908328","span":{"begin":570,"end":571},"obj":"19370590"},{"id":"25988110-22085317-908329","span":{"begin":808,"end":809},"obj":"22085317"}],"attributes":[{"subj":"25988110-24880830-908325","pred":"source","obj":"0_colil"},{"subj":"25988110-24570244-908326","pred":"source","obj":"0_colil"},{"subj":"25988110-16733522-908327","pred":"source","obj":"0_colil"},{"subj":"25988110-19370590-908328","pred":"source","obj":"0_colil"},{"subj":"25988110-22085317-908329","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"25988110-24880830-38724252","span":{"begin":49,"end":50},"obj":"24880830"},{"id":"25988110-24570244-38724253","span":{"begin":163,"end":164},"obj":"24570244"},{"id":"25988110-16733522-38724254","span":{"begin":346,"end":347},"obj":"16733522"},{"id":"25988110-19370590-38724255","span":{"begin":570,"end":571},"obj":"19370590"},{"id":"25988110-22085317-38724256","span":{"begin":808,"end":809},"obj":"22085317"}],"attributes":[{"subj":"25988110-24880830-38724252","pred":"source","obj":"2_test"},{"subj":"25988110-24570244-38724253","pred":"source","obj":"2_test"},{"subj":"25988110-16733522-38724254","pred":"source","obj":"2_test"},{"subj":"25988110-19370590-38724255","pred":"source","obj":"2_test"},{"subj":"25988110-22085317-38724256","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"0_colil","color":"#ec9397","default":true},{"id":"2_test","color":"#93b1ec"}]}]}}