PMC:4419340 / 39403-39794 JSONTXT

Statistical analysis. Data were analyzed with the nonparametric statistical test (Mann–Whitney test) with Prism software (GraphPad Software), and P < 0.05 or P < 0.01 was considered statistically significant. Biological proximities between IL17RC and the known CMC-causing genes IL17RA and ACT1 were estimated using the human gene connectome method and its online server (Itan et al., 2014).