PMC:4419340 / 310-1335 JSONTXT

{"project":"Biotea","denotations":[{"id":"T3","span":{"begin":464,"end":471},"obj":"http://purl.obolibrary.org/obo/PR_000008983"},{"id":"T4","span":{"begin":574,"end":581},"obj":"http://purl.obolibrary.org/obo/PR_000008983"},{"id":"T5","span":{"begin":926,"end":933},"obj":"http://purl.obolibrary.org/obo/PR_000008983"},{"id":"T7","span":{"begin":267,"end":277},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/246199000"},{"id":"T8","span":{"begin":472,"end":482},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/246199000"},{"id":"T10","span":{"begin":267,"end":277},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94372"},{"id":"T11","span":{"begin":472,"end":482},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94372"},{"id":"T13","span":{"begin":267,"end":277},"obj":"http://purl.bioontology.org/ontology/MESH/Q000172"},{"id":"T14","span":{"begin":472,"end":482},"obj":"http://purl.bioontology.org/ontology/MESH/Q000172"},{"id":"T16","span":{"begin":348,"end":356},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16960"},{"id":"T17","span":{"begin":374,"end":382},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16960"},{"id":"T18","span":{"begin":488,"end":496},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16960"},{"id":"T19","span":{"begin":779,"end":787},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16960"},{"id":"T20","span":{"begin":868,"end":876},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16960"},{"id":"T22","span":{"begin":348,"end":356},"obj":"http://purl.bioontology.org/ontology/MESH/D010361"},{"id":"T23","span":{"begin":374,"end":382},"obj":"http://purl.bioontology.org/ontology/MESH/D010361"},{"id":"T24","span":{"begin":488,"end":496},"obj":"http://purl.bioontology.org/ontology/MESH/D010361"},{"id":"T25","span":{"begin":779,"end":787},"obj":"http://purl.bioontology.org/ontology/MESH/D010361"},{"id":"T26","span":{"begin":868,"end":876},"obj":"http://purl.bioontology.org/ontology/MESH/D010361"},{"id":"T28","span":{"begin":0,"end":33},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU011379"},{"id":"T30","span":{"begin":0,"end":33},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34444"},{"id":"T32","span":{"begin":0,"end":33},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10009007"},{"id":"T34","span":{"begin":0,"end":33},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/234568006"},{"id":"T36","span":{"begin":0,"end":7},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/90734009"},{"id":"T38","span":{"begin":0,"end":7},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14141"},{"id":"T40","span":{"begin":8,"end":33},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU014262"},{"id":"T42","span":{"begin":8,"end":33},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/29147005"},{"id":"T44","span":{"begin":8,"end":33},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35576"},{"id":"T46","span":{"begin":8,"end":33},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10028080"},{"id":"T48","span":{"begin":22,"end":33},"obj":"http://purl.bioontology.org/ontology/ICD10/B37"},{"id":"T50","span":{"begin":22,"end":33},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0006840"},{"id":"T52","span":{"begin":22,"end":33},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10007152"},{"id":"T54","span":{"begin":22,"end":33},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU042170"},{"id":"T56","span":{"begin":22,"end":33},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26711"},{"id":"T58","span":{"begin":22,"end":33},"obj":"http://purl.bioontology.org/ontology/MESH/D002177"},{"id":"T60","span":{"begin":22,"end":33},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000000650"},{"id":"T62","span":{"begin":22,"end":33},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/78048006"},{"id":"T63","span":{"begin":35,"end":38},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9610"},{"id":"T64","span":{"begin":323,"end":326},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9610"},{"id":"T65","span":{"begin":444,"end":447},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9610"},{"id":"T66","span":{"begin":35,"end":38},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118497"},{"id":"T67","span":{"begin":323,"end":326},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118497"},{"id":"T68","span":{"begin":444,"end":447},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118497"},{"id":"T69","span":{"begin":43,"end":56},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62606"},{"id":"T70","span":{"begin":60,"end":69},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/255227004"},{"id":"T71","span":{"begin":60,"end":69},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14173"},{"id":"T72","span":{"begin":73,"end":83},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C124570"},{"id":"T73","span":{"begin":73,"end":83},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43623"},{"id":"T74","span":{"begin":84,"end":94},"obj":"http://purl.bioontology.org/ontology/MESH/D007239"},{"id":"T75","span":{"begin":84,"end":94},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C3714514"},{"id":"T76","span":{"begin":102,"end":106},"obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"T77","span":{"begin":102,"end":106},"obj":"http://purl.bioontology.org/ontology/MESH/D012867"},{"id":"T78","span":{"begin":102,"end":106},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C23404"},{"id":"T79","span":{"begin":102,"end":106},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12470"},{"id":"T80","span":{"begin":102,"end":106},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/39937001"},{"id":"T81","span":{"begin":102,"end":106},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU000083"},{"id":"T82","span":{"begin":108,"end":112},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104070"},{"id":"T83","span":{"begin":108,"end":112},"obj":"http://purl.obolibrary.org/obo/PR_000001896"},{"id":"T84","span":{"begin":108,"end":112},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104069"},{"id":"T85","span":{"begin":108,"end":112},"obj":"http://purl.org/sig/ont/fma/fma54326"},{"id":"T86","span":{"begin":108,"end":112},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33156"},{"id":"T87","span":{"begin":114,"end":118},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42744"},{"id":"T88","span":{"begin":114,"end":118},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/738956005"},{"id":"T89","span":{"begin":114,"end":118},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38288"},{"id":"T90","span":{"begin":114,"end":118},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/260548002"},{"id":"T91","span":{"begin":114,"end":118},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12421"},{"id":"T92","span":{"begin":114,"end":118},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25311"},{"id":"T93","span":{"begin":124,"end":131},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13348"},{"id":"T94","span":{"begin":124,"end":131},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/263767004"},{"id":"T95","span":{"begin":145,"end":152},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/3265006"},{"id":"T96","span":{"begin":145,"end":152},"obj":"http://purl.bioontology.org/ontology/MESH/D002175"},{"id":"T97","span":{"begin":145,"end":152},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77163"},{"id":"T98","span":{"begin":153,"end":160},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96433"},{"id":"T99","span":{"begin":153,"end":160},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45293"},{"id":"T100","span":{"begin":153,"end":160},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77808"},{"id":"T101","span":{"begin":169,"end":180},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77170"},{"id":"T102","span":{"begin":977,"end":988},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77170"},{"id":"T103","span":{"begin":182,"end":191},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C32168"},{"id":"T104","span":{"begin":241,"end":250},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C32168"},{"id":"T105","span":{"begin":207,"end":214},"obj":"http://purl.obolibrary.org/obo/PR_000001375"},{"id":"T106","span":{"begin":207,"end":214},"obj":"http://purl.obolibrary.org/obo/PR_Q60943"},{"id":"T107","span":{"begin":219,"end":223},"obj":"http://purl.obolibrary.org/obo/PR_000016602"},{"id":"T108","span":{"begin":764,"end":768},"obj":"http://purl.obolibrary.org/obo/PR_000016602"},{"id":"T109","span":{"begin":219,"end":223},"obj":"http://purl.bioontology.org/ontology/OMIM/607043"},{"id":"T110","span":{"begin":764,"end":768},"obj":"http://purl.bioontology.org/ontology/OMIM/607043"},{"id":"T111","span":{"begin":251,"end":259},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25487"},{"id":"T112","span":{"begin":260,"end":266},"obj":"http://purl.obolibrary.org/obo/PR_Q5BJ95"},{"id":"T113","span":{"begin":671,"end":677},"obj":"http://purl.obolibrary.org/obo/PR_Q5BJ95"},{"id":"T114","span":{"begin":260,"end":266},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114484"},{"id":"T115","span":{"begin":671,"end":677},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114484"},{"id":"T116","span":{"begin":260,"end":266},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114482"},{"id":"T117","span":{"begin":671,"end":677},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114482"},{"id":"T118","span":{"begin":260,"end":266},"obj":"http://purl.obolibrary.org/obo/PR_000001142"},{"id":"T119","span":{"begin":671,"end":677},"obj":"http://purl.obolibrary.org/obo/PR_000001142"},{"id":"T120","span":{"begin":284,"end":292},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/733985002"},{"id":"T121","span":{"begin":284,"end":292},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25375"},{"id":"T122","span":{"begin":361,"end":367},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25375"},{"id":"T123","span":{"begin":298,"end":304},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48440"},{"id":"T124","span":{"begin":298,"end":304},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150721"},{"id":"T125","span":{"begin":298,"end":304},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/125681006"},{"id":"T126","span":{"begin":340,"end":347},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115935"},{"id":"T127","span":{"begin":361,"end":367},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/229059009"},{"id":"T128","span":{"begin":361,"end":367},"obj":"http://purl.obolibrary.org/obo/IAO_0000088"},{"id":"T129","span":{"begin":361,"end":367},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97107"},{"id":"T130","span":{"begin":368,"end":373},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66834"},{"id":"T131","span":{"begin":368,"end":373},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/79605009"},{"id":"T132","span":{"begin":388,"end":397},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/262241003"},{"id":"T133","span":{"begin":388,"end":397},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C53256"},{"id":"T134","span":{"begin":388,"end":397},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25328"},{"id":"T135","span":{"begin":408,"end":412},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25150"},{"id":"T136","span":{"begin":408,"end":412},"obj":"http://purl.bioontology.org/ontology/MESH/D000368"},{"id":"T137","span":{"begin":435,"end":443},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/46651001"},{"id":"T138","span":{"begin":435,"end":443},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25549"},{"id":"T139","span":{"begin":453,"end":460},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49927"},{"id":"T140","span":{"begin":453,"end":460},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25485"},{"id":"T141","span":{"begin":501,"end":511},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45826"},{"id":"T142","span":{"begin":535,"end":542},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16277"},{"id":"T143","span":{"begin":535,"end":542},"obj":"http://purl.bioontology.org/ontology/MESH/D000483"},{"id":"T144","span":{"begin":560,"end":570},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80488"},{"id":"T145","span":{"begin":560,"end":570},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/706999006"},{"id":"T146","span":{"begin":560,"end":570},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16608"},{"id":"T147","span":{"begin":560,"end":570},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/10012005"},{"id":"T148","span":{"begin":589,"end":601},"obj":"http://purl.obolibrary.org/obo/GO_0009986"},{"id":"T149","span":{"begin":589,"end":601},"obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"T150","span":{"begin":589,"end":601},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33974"},{"id":"T151","span":{"begin":589,"end":593},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T152","span":{"begin":589,"end":593},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T153","span":{"begin":589,"end":593},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T154","span":{"begin":589,"end":593},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T155","span":{"begin":589,"end":593},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T156","span":{"begin":589,"end":593},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T157","span":{"begin":589,"end":593},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T158","span":{"begin":589,"end":593},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T159","span":{"begin":589,"end":593},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T160","span":{"begin":589,"end":593},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49867"},{"id":"T161","span":{"begin":589,"end":593},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T162","span":{"begin":589,"end":593},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12508"},{"id":"T163","span":{"begin":638,"end":646},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12508"},{"id":"T164","span":{"begin":589,"end":593},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C23442"},{"id":"T165","span":{"begin":589,"end":593},"obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"T166","span":{"begin":589,"end":593},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T167","span":{"begin":589,"end":593},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T168","span":{"begin":589,"end":593},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C60787"},{"id":"T169","span":{"begin":589,"end":593},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48694"},{"id":"T170","span":{"begin":589,"end":593},"obj":"http://purl.bioontology.org/ontology/MESH/D002477"},{"id":"T171","span":{"begin":594,"end":601},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25245"},{"id":"T172","span":{"begin":594,"end":601},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/410678000"},{"id":"T173","span":{"begin":594,"end":601},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/410679008"},{"id":"T174","span":{"begin":607,"end":613},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43429"},{"id":"T175","span":{"begin":607,"end":613},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/6920004"},{"id":"T176","span":{"begin":617,"end":625},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64943"},{"id":"T177","span":{"begin":617,"end":625},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C127315"},{"id":"T178","span":{"begin":617,"end":625},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/255594003"},{"id":"T179","span":{"begin":617,"end":625},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25250"},{"id":"T180","span":{"begin":638,"end":646},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111153"},{"id":"T181","span":{"begin":660,"end":666},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20519"},{"id":"T182","span":{"begin":660,"end":666},"obj":"http://purl.obolibrary.org/obo/PR_000001138"},{"id":"T183","span":{"begin":660,"end":666},"obj":"http://purl.obolibrary.org/obo/PR_Q61453"},{"id":"T184","span":{"begin":660,"end":666},"obj":"http://purl.obolibrary.org/obo/PR_Q62386"},{"id":"T185","span":{"begin":714,"end":722},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70754"},{"id":"T186","span":{"begin":714,"end":722},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C390"},{"id":"T187","span":{"begin":734,"end":742},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25599"},{"id":"T188","span":{"begin":769,"end":778},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/260372006"},{"id":"T189","span":{"begin":800,"end":808},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25755"},{"id":"T190","span":{"begin":800,"end":808},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C50995"},{"id":"T191","span":{"begin":800,"end":808},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49149"},{"id":"T192","span":{"begin":800,"end":808},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82658"},{"id":"T193","span":{"begin":812,"end":818},"obj":"http://purl.obolibrary.org/obo/GO_0030380"},{"id":"T194","span":{"begin":812,"end":818},"obj":"http://purl.obolibrary.org/obo/PR_000001113"},{"id":"T195","span":{"begin":820,"end":825},"obj":"http://purl.obolibrary.org/obo/PR_000001113"},{"id":"T196","span":{"begin":812,"end":818},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97960"},{"id":"T197","span":{"begin":820,"end":825},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97960"},{"id":"T198","span":{"begin":820,"end":825},"obj":"http://purl.obolibrary.org/obo/PR_000045517"},{"id":"T199","span":{"begin":820,"end":825},"obj":"http://purl.obolibrary.org/obo/PR_Q9CPT4"},{"id":"T200","span":{"begin":820,"end":825},"obj":"http://purl.obolibrary.org/obo/GO_0045521"},{"id":"T201","span":{"begin":830,"end":840},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/385630006"},{"id":"T202","span":{"begin":899,"end":905},"obj":"http://purl.bioontology.org/ontology/MESH/D019368"},{"id":"T203","span":{"begin":899,"end":905},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/246425008"},{"id":"T204","span":{"begin":920,"end":925},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14225"},{"id":"T205","span":{"begin":920,"end":925},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T206","span":{"begin":920,"end":925},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T207","span":{"begin":920,"end":925},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T208","span":{"begin":920,"end":925},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T209","span":{"begin":920,"end":925},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T210","span":{"begin":920,"end":925},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T211","span":{"begin":920,"end":925},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T212","span":{"begin":920,"end":925},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T213","span":{"begin":920,"end":925},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T214","span":{"begin":920,"end":925},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T215","span":{"begin":920,"end":925},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T216","span":{"begin":937,"end":946},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71578"},{"id":"T217","span":{"begin":937,"end":946},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/34325006"},{"id":"T218","span":{"begin":965,"end":973},"obj":"http://purl.bioontology.org/ontology/MESH/D007109"},{"id":"T219","span":{"begin":965,"end":973},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16710"},{"id":"T220","span":{"begin":1014,"end":1023},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C55286"}],"namespaces":[{"prefix":"omim","uri":"http://purl.bioontology.org/ontology/OMIM/"},{"prefix":"pr","uri":"http://purl.obolibrary.org/obo/PR_"}],"text":"Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent infections of the skin, nail, oral, and genital mucosae with Candida species, mainly C. albicans. Autosomal-recessive (AR) IL-17RA and ACT1 deficiencies and autosomal-dominant IL-17F deficiency, each reported in a single kindred, underlie CMC in otherwise healthy patients. We report three patients from unrelated kindreds, aged 8, 12, and 37 yr with isolated CMC, who display AR IL-17RC deficiency. The patients are homozygous for different nonsense alleles that prevent the expression of IL-17RC on the cell surface. The defect is complete, abolishing cellular responses to IL-17A and IL-17F homo- and heterodimers. However, in contrast to what is observed for the IL-17RA– and ACT1-deficient patients tested, the response to IL-17E (IL-25) is maintained in these IL-17RC–deficient patients. These experiments of nature indicate that human IL-17RC is essential for mucocutaneous immunity to C. albicans but is otherwise largely redundant.\n"}