PMC:441373 / 4891-38783 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1593	24-26	FW	denotes	In
T1594	27-33	FW	denotes	silico
T1595	34-48	NN	denotes	identification
T1596	49-51	IN	denotes	of
T1597	52-56	NN	denotes	TACC
T1598	64-71	NNS	denotes	members
T1599	57-63	NN	denotes	family
T1600	72-76	IN	denotes	from
T1601	77-87	NN	denotes	vertebrate
T1602	105-113	NNS	denotes	lineages
T1603	88-91	CC	denotes	and
T1604	92-104	NN	denotes	invertebrate
T1605	113-362	sentence	denotes	Sequence similarity searches of the publicly available genome databases with the BLAST and TBLAST programs were performed to identify TACC and RHAMM orthologues, and other members of the coiled coil superfamily in a diverse set of species (Fig. 1).
T1606	114-122	NN	denotes	Sequence
T1607	123-133	NN	denotes	similarity
T1608	134-142	NNS	denotes	searches
T1609	226-235	VBN	denotes	performed
T1610	143-145	IN	denotes	of
T1611	146-149	DT	denotes	the
T1612	176-185	NNS	denotes	databases
T1613	150-158	RB	denotes	publicly
T1614	159-168	JJ	denotes	available
T1615	169-175	NN	denotes	genome
T1616	186-190	IN	denotes	with
T1617	191-194	DT	denotes	the
T1618	212-220	NNS	denotes	programs
T1619	195-200	NN	denotes	BLAST
T1620	201-204	CC	denotes	and
T1621	205-211	NN	denotes	TBLAST
T1622	221-225	VBD	denotes	were
T1623	236-238	TO	denotes	to
T1624	239-247	VB	denotes	identify
T1625	248-252	NN	denotes	TACC
T1626	263-274	NNS	denotes	orthologues
T1627	253-256	CC	denotes	and
T1628	257-262	NN	denotes	RHAMM
T1629	274-276	,	denotes	,
T1630	276-279	CC	denotes	and
T1631	280-285	JJ	denotes	other
T1632	286-293	NNS	denotes	members
T1633	294-296	IN	denotes	of
T1634	297-300	DT	denotes	the
T1635	313-324	NN	denotes	superfamily
T1636	301-307	VBN	denotes	coiled
T1637	308-312	NN	denotes	coil
T1638	325-327	IN	denotes	in
T1639	328-329	DT	denotes	a
T1640	338-341	NN	denotes	set
T1641	330-337	JJ	denotes	diverse
T1642	342-344	IN	denotes	of
T1643	345-352	NNS	denotes	species
T1644	353-354	-LRB-	denotes	(
T1645	354-358	NN	denotes	Fig.
T1646	359-360	CD	denotes	1
T1647	360-361	-RRB-	denotes	)
T1648	361-362	.	denotes	.
T1649	362-485	sentence	denotes	This identified the complete sequence of the TACC genes in representatives of five major phylogenetically distinct clades.
T1650	363-367	DT	denotes	This
T1651	368-378	VBD	denotes	identified
T1652	379-382	DT	denotes	the
T1653	392-400	NN	denotes	sequence
T1654	383-391	JJ	denotes	complete
T1655	401-403	IN	denotes	of
T1656	404-407	DT	denotes	the
T1657	413-418	NNS	denotes	genes
T1658	408-412	NN	denotes	TACC
T1659	419-421	IN	denotes	in
T1660	422-437	NNS	denotes	representatives
T1661	438-440	IN	denotes	of
T1662	441-445	CD	denotes	five
T1663	478-484	NNS	denotes	clades
T1664	446-451	JJ	denotes	major
T1665	452-468	RB	denotes	phylogenetically
T1666	469-477	JJ	denotes	distinct
T1667	484-485	.	denotes	.
T1668	485-619	sentence	denotes	Where possible, the construction of the TACC sequences from these organisms was also confirmed by the analysis of the cDNA databases.
T1669	486-491	WRB	denotes	Where
T1670	492-500	JJ	denotes	possible
T1671	571-580	VBN	denotes	confirmed
T1672	500-502	,	denotes	,
T1673	502-505	DT	denotes	the
T1674	506-518	NN	denotes	construction
T1675	519-521	IN	denotes	of
T1676	522-525	DT	denotes	the
T1677	531-540	NNS	denotes	sequences
T1678	526-530	NN	denotes	TACC
T1679	541-545	IN	denotes	from
T1680	546-551	DT	denotes	these
T1681	552-561	NNS	denotes	organisms
T1682	562-565	VBD	denotes	was
T1683	566-570	RB	denotes	also
T1684	581-583	IN	denotes	by
T1685	584-587	DT	denotes	the
T1686	588-596	NN	denotes	analysis
T1687	597-599	IN	denotes	of
T1688	600-603	DT	denotes	the
T1689	609-618	NNS	denotes	databases
T1690	604-608	NN	denotes	cDNA
T1691	618-619	.	denotes	.
T1692	619-863	sentence	denotes	Several partial sequences in other vertebrate species, the echinodermate Strongylocentrotus purpuratus and the protostome insect Anopheles gambiae were also identified, suggesting an ancient conservation of the TACC genes in metazoan lineages.
T1693	620-627	JJ	denotes	Several
T1694	636-645	NNS	denotes	sequences
T1695	628-635	JJ	denotes	partial
T1696	777-787	VBN	denotes	identified
T1697	646-648	IN	denotes	in
T1698	649-654	JJ	denotes	other
T1699	666-673	NNS	denotes	species
T1700	655-665	NN	denotes	vertebrate
T1701	673-675	,	denotes	,
T1702	675-678	DT	denotes	the
T1703	679-692	JJ	denotes	echinodermate
T1704	693-711	NNP	denotes	Strongylocentrotus
T1705	712-722	NNP	denotes	purpuratus
T1706	723-726	CC	denotes	and
T1707	727-730	DT	denotes	the
T1708	742-748	NN	denotes	insect
T1709	731-741	NN	denotes	protostome
T1714	787-789	,	denotes	,
T1715	789-799	VBG	denotes	suggesting
T1716	800-802	DT	denotes	an
T1717	811-823	NN	denotes	conservation
T1718	803-810	JJ	denotes	ancient
T1719	824-826	IN	denotes	of
T1720	827-830	DT	denotes	the
T1721	836-841	NNS	denotes	genes
T1722	831-835	NN	denotes	TACC
T1723	842-844	IN	denotes	in
T1724	845-853	NN	denotes	metazoan
T1725	854-862	NNS	denotes	lineages
T1726	862-863	.	denotes	.
T1727	863-1027	sentence	denotes	However, due to the relative infancy of the cDNA/genome projects for these latter organisms, complete characterization of these TACC genes could not be undertaken.
T1728	864-871	RB	denotes	However
T1729	1016-1026	VBN	denotes	undertaken
T1730	871-873	,	denotes	,
T1731	873-876	IN	denotes	due
T1732	877-879	IN	denotes	to
T1733	880-883	DT	denotes	the
T1734	893-900	NN	denotes	infancy
T1735	884-892	JJ	denotes	relative
T1736	901-903	IN	denotes	of
T1737	904-907	DT	denotes	the
T1738	920-928	NNS	denotes	projects
T1739	908-912	NN	denotes	cDNA
T1740	913-919	NN	denotes	genome
T1741	912-913	HYPH	denotes	/
T1742	929-932	IN	denotes	for
T1743	933-938	DT	denotes	these
T1744	946-955	NNS	denotes	organisms
T1745	939-945	JJ	denotes	latter
T1746	955-957	,	denotes	,
T1747	957-965	JJ	denotes	complete
T1748	966-982	NN	denotes	characterization
T1749	983-985	IN	denotes	of
T1750	986-991	DT	denotes	these
T1751	997-1002	NNS	denotes	genes
T1752	992-996	NN	denotes	TACC
T1753	1003-1008	MD	denotes	could
T1754	1009-1012	RB	denotes	not
T1755	1013-1015	VB	denotes	be
T1756	1026-1027	.	denotes	.
T1757	1027-1335	sentence	denotes	No conclusion could be made about the existence of TACC-like sequence in non-bilaterian metazoans, such as Cnidaria or Porifera, due to the paucity of sequence information for these organisms, and additional definitive sequences with a defined TACC domain could not be found in other non-metazoan organisms.
T1758	1028-1030	DT	denotes	No
T1759	1031-1041	NN	denotes	conclusion
T1760	1051-1055	VBN	denotes	made
T1761	1042-1047	MD	denotes	could
T1762	1048-1050	VB	denotes	be
T1763	1056-1061	IN	denotes	about
T1764	1062-1065	DT	denotes	the
T1765	1066-1075	NN	denotes	existence
T1766	1076-1078	IN	denotes	of
T1767	1079-1083	NN	denotes	TACC
T1768	1084-1088	JJ	denotes	like
T1769	1083-1084	HYPH	denotes	-
T1770	1089-1097	NN	denotes	sequence
T1771	1098-1100	IN	denotes	in
T1772	1101-1115	JJ	denotes	non-bilaterian
T1773	1116-1125	NNS	denotes	metazoans
T1774	1125-1127	,	denotes	,
T1775	1127-1131	JJ	denotes	such
T1776	1132-1134	IN	denotes	as
T1777	1135-1143	NNP	denotes	Cnidaria
T1778	1144-1146	CC	denotes	or
T1779	1147-1155	NNP	denotes	Porifera
T1780	1155-1157	,	denotes	,
T1781	1157-1160	IN	denotes	due
T1782	1161-1163	IN	denotes	to
T1783	1164-1167	DT	denotes	the
T1784	1168-1175	NN	denotes	paucity
T1785	1176-1178	IN	denotes	of
T1786	1179-1187	NN	denotes	sequence
T1787	1188-1199	NN	denotes	information
T1788	1200-1203	IN	denotes	for
T1789	1204-1209	DT	denotes	these
T1790	1210-1219	NNS	denotes	organisms
T1791	1219-1221	,	denotes	,
T1792	1221-1224	CC	denotes	and
T1793	1225-1235	JJ	denotes	additional
T1794	1247-1256	NNS	denotes	sequences
T1795	1236-1246	JJ	denotes	definitive
T1796	1297-1302	VBN	denotes	found
T1797	1257-1261	IN	denotes	with
T1798	1262-1263	DT	denotes	a
T1799	1277-1283	NN	denotes	domain
T1800	1264-1271	VBN	denotes	defined
T1801	1272-1276	NN	denotes	TACC
T1802	1284-1289	MD	denotes	could
T1803	1290-1293	RB	denotes	not
T1804	1294-1296	VB	denotes	be
T1805	1303-1305	IN	denotes	in
T1806	1306-1311	JJ	denotes	other
T1807	1325-1334	NNS	denotes	organisms
T1808	1312-1324	JJ	denotes	non-metazoan
T1809	1334-1335	.	denotes	.
T1810	1335-1336	sentence	denotes
T1811	1828-1835	sentence	denotes	At the
T1851	1939-1944	NNP	denotes	Ciona
T1852	1945-1957	NNP	denotes	intestinalis
T1853	1958-1959	-LRB-	denotes	[
T1854	1959-1961	CD	denotes	11
T1855	1961-1962	-RRB-	denotes	]
T1856	1962-1964	,	denotes	,
T1857	1964-1967	CC	denotes	and
T1858	1968-1969	DT	denotes	a
T1859	1983-1991	NN	denotes	sequence
T1860	1970-1977	JJ	denotes	partial
T1861	1978-1982	NN	denotes	TACC
T1862	1992-1996	IN	denotes	from
T1863	1997-1999	DT	denotes	an
T1864	2000-2008	NN	denotes	analysis
T1865	2009-2011	IN	denotes	of
T1866	2012-2015	DT	denotes	the
T1867	2040-2048	NN	denotes	database
T1868	2016-2027	NNP	denotes	Halocynthia
T1869	2028-2035	NNP	denotes	rortezi
T1870	2036-2039	NN	denotes	EST
T1871	2049-2050	-LRB-	denotes	[
T1872	2050-2052	CD	denotes	12
T1873	2052-2053	-RRB-	denotes	]
T1874	2053-2054	.	denotes	.
T1875	2054-2154	sentence	denotes	This confirms the original assumption that a single TACC gene was present in the chordate ancestor.
T1876	2055-2059	DT	denotes	This
T1877	2060-2068	VBZ	denotes	confirms
T1878	2069-2072	DT	denotes	the
T1879	2082-2092	NN	denotes	assumption
T1880	2073-2081	JJ	denotes	original
T1881	2093-2097	IN	denotes	that
T1882	2117-2120	VBD	denotes	was
T1883	2098-2099	DT	denotes	a
T1884	2112-2116	NN	denotes	gene
T1885	2100-2106	JJ	denotes	single
T1886	2107-2111	NN	denotes	TACC
T1887	2121-2128	JJ	denotes	present
T1888	2129-2131	IN	denotes	in
T1889	2132-2135	DT	denotes	the
T1890	2145-2153	NN	denotes	ancestor
T1891	2136-2144	NN	denotes	chordate
T1892	2153-2154	.	denotes	.
T1893	2154-2394	sentence	denotes	The next major event in the evolution of the chordate genome has been suggested to have occurred 687 ± 155.7 million years ago (MYA), with the first duplication of the chordate genome, and a second duplication occurring shortly thereafter.
T1894	2155-2158	DT	denotes	The
T1895	2170-2175	NN	denotes	event
T1896	2159-2163	JJ	denotes	next
T1897	2164-2169	JJ	denotes	major
T1898	2225-2234	VBN	denotes	suggested
T1899	2176-2178	IN	denotes	in
T1900	2179-2182	DT	denotes	the
T1901	2183-2192	NN	denotes	evolution
T1902	2193-2195	IN	denotes	of
T1903	2196-2199	DT	denotes	the
T1904	2209-2215	NN	denotes	genome
T1905	2200-2208	NN	denotes	chordate
T1906	2216-2219	VBZ	denotes	has
T1907	2220-2224	VBN	denotes	been
T1908	2235-2237	TO	denotes	to
T1909	2243-2251	VBN	denotes	occurred
T1910	2238-2242	VB	denotes	have
T1911	2252-2255	CD	denotes	687
T1912	2258-2263	CD	denotes	155.7
T1913	2256-2257	SYM	denotes	±
T1914	2272-2277	NNS	denotes	years
T1915	2264-2271	CD	denotes	million
T1916	2278-2281	RB	denotes	ago
T1917	2282-2283	-LRB-	denotes	(
T1918	2283-2286	RB	denotes	MYA
T1919	2286-2287	-RRB-	denotes	)
T1920	2287-2289	,	denotes	,
T1921	2289-2293	IN	denotes	with
T1922	2294-2297	DT	denotes	the
T1923	2304-2315	NN	denotes	duplication
T1924	2298-2303	JJ	denotes	first
T1925	2316-2318	IN	denotes	of
T1926	2319-2322	DT	denotes	the
T1927	2332-2338	NN	denotes	genome
T1928	2323-2331	NN	denotes	chordate
T1929	2338-2340	,	denotes	,
T1930	2340-2343	CC	denotes	and
T1931	2344-2345	DT	denotes	a
T1932	2353-2364	NN	denotes	duplication
T1933	2346-2352	JJ	denotes	second
T1934	2365-2374	VBG	denotes	occurring
T1935	2375-2382	RB	denotes	shortly
T1936	2383-2393	RB	denotes	thereafter
T1937	2393-2394	.	denotes	.
T1938	2394-2833	sentence	denotes	Thus, if the TACC genes were duplicated at both events, we would expect to identify four TACC genes in the most "primitive" compact vertebrate genome sequenced to date, the pufferfish Takifugu rubripes, with three genes corresponding to the human TACC1-3, and, in keeping with the proposed model for genomic duplication of the chromosomal loci for the TACC genes (discussed below), a possible fourth gene deriving from the TACC3 ancestor.
T1939	2395-2399	RB	denotes	Thus
T1940	2460-2466	VB	denotes	expect
T1941	2399-2401	,	denotes	,
T1942	2401-2403	IN	denotes	if
T1943	2424-2434	VBN	denotes	duplicated
T1944	2404-2407	DT	denotes	the
T1945	2413-2418	NNS	denotes	genes
T1946	2408-2412	NN	denotes	TACC
T1947	2419-2423	VBD	denotes	were
T1948	2435-2437	IN	denotes	at
T1949	2438-2442	DT	denotes	both
T1950	2443-2449	NNS	denotes	events
T1951	2449-2451	,	denotes	,
T1952	2451-2453	PRP	denotes	we
T1953	2454-2459	MD	denotes	would
T1954	2467-2469	TO	denotes	to
T1955	2470-2478	VB	denotes	identify
T1956	2479-2483	CD	denotes	four
T1957	2489-2494	NNS	denotes	genes
T1958	2484-2488	NN	denotes	TACC
T1959	2495-2497	IN	denotes	in
T1960	2498-2501	DT	denotes	the
T1961	2538-2544	NN	denotes	genome
T1962	2502-2506	JJS	denotes	most
T1963	2508-2517	JJ	denotes	primitive
T1964	2507-2508	``	denotes	"
T1965	2517-2518	''	denotes	"
T1966	2519-2526	JJ	denotes	compact
T1967	2527-2537	NN	denotes	vertebrate
T1968	2545-2554	VBN	denotes	sequenced
T1969	2555-2557	IN	denotes	to
T1970	2558-2562	NN	denotes	date
T1971	2562-2564	,	denotes	,
T1972	2564-2567	DT	denotes	the
T1973	2568-2578	NN	denotes	pufferfish
T1974	2579-2587	NNP	denotes	Takifugu
T1975	2588-2596	NNP	denotes	rubripes
T1976	2596-2598	,	denotes	,
T1977	2598-2602	IN	denotes	with
T1978	2603-2608	CD	denotes	three
T1979	2609-2614	NNS	denotes	genes
T1980	2615-2628	VBG	denotes	corresponding
T1981	2629-2631	IN	denotes	to
T1982	2632-2635	DT	denotes	the
T1983	2642-2647	NN	denotes	TACC1
T1984	2636-2641	JJ	denotes	human
T1985	2647-2648	HYPH	denotes	-
T1986	2648-2649	CD	denotes	3
T1987	2649-2651	,	denotes	,
T1988	2651-2654	CC	denotes	and
T1989	2654-2656	,	denotes	,
T1990	2656-2658	IN	denotes	in
T1991	2795-2799	NN	denotes	gene
T1992	2659-2666	VBG	denotes	keeping
T1993	2667-2671	IN	denotes	with
T1994	2672-2675	DT	denotes	the
T1995	2685-2690	NN	denotes	model
T1996	2676-2684	VBN	denotes	proposed
T1997	2691-2694	IN	denotes	for
T1998	2695-2702	JJ	denotes	genomic
T1999	2703-2714	NN	denotes	duplication
T2000	2715-2717	IN	denotes	of
T2001	2718-2721	DT	denotes	the
T2002	2734-2738	NNS	denotes	loci
T2003	2722-2733	JJ	denotes	chromosomal
T2004	2739-2742	IN	denotes	for
T2005	2743-2746	DT	denotes	the
T2006	2752-2757	NNS	denotes	genes
T2007	2747-2751	NN	denotes	TACC
T2008	2758-2759	-LRB-	denotes	(
T2009	2759-2768	VBN	denotes	discussed
T2010	2769-2774	RB	denotes	below
T2011	2774-2775	-RRB-	denotes	)
T2012	2775-2777	,	denotes	,
T2013	2777-2778	DT	denotes	a
T2014	2779-2787	JJ	denotes	possible
T2015	2788-2794	JJ	denotes	fourth
T2016	2800-2808	VBG	denotes	deriving
T2017	2809-2813	IN	denotes	from
T2018	2814-2817	DT	denotes	the
T2019	2824-2832	NN	denotes	ancestor
T2020	2818-2823	NN	denotes	TACC3
T2021	2832-2833	.	denotes	.
T2022	2833-2889	sentence	denotes	Indeed, four TACC genes were identified in T. rubripes.
T2023	2834-2840	RB	denotes	Indeed
T2024	2863-2873	VBN	denotes	identified
T2025	2840-2842	,	denotes	,
T2026	2842-2846	CD	denotes	four
T2027	2852-2857	NNS	denotes	genes
T2028	2847-2851	NN	denotes	TACC
T2029	2858-2862	VBD	denotes	were
T2030	2874-2876	IN	denotes	in
T2031	2877-2879	NNP	denotes	T.
T2032	2880-2888	NNP	denotes	rubripes
T2033	2888-2889	.	denotes	.
T2034	2889-2979	sentence	denotes	Of these, two genes corresponded to the T. rubripes orthologues of human TACC2 and TACC3.
T2035	2890-2892	IN	denotes	Of
T2036	2910-2922	VBD	denotes	corresponded
T2037	2893-2898	DT	denotes	these
T2038	2898-2900	,	denotes	,
T2039	2900-2903	CD	denotes	two
T2040	2904-2909	NNS	denotes	genes
T2041	2923-2925	IN	denotes	to
T2042	2926-2929	DT	denotes	the
T2043	2942-2953	NNS	denotes	orthologues
T2044	2930-2932	NNP	denotes	T.
T2045	2933-2941	NNP	denotes	rubripes
T2046	2954-2956	IN	denotes	of
T2047	2957-2962	JJ	denotes	human
T2048	2963-2968	NN	denotes	TACC2
T2049	2969-2972	CC	denotes	and
T2050	2973-2978	NN	denotes	TACC3
T2051	2978-2979	.	denotes	.
T2052	2979-3075	sentence	denotes	However, the other two genes, trTACC1A and trTACC1B are clearly most related to TACC1 (Fig. 1).
T2053	2980-2987	RB	denotes	However
T2054	3032-3035	VBP	denotes	are
T2055	2987-2989	,	denotes	,
T2056	2989-2992	DT	denotes	the
T2057	3003-3008	NNS	denotes	genes
T2058	2993-2998	JJ	denotes	other
T2059	2999-3002	CD	denotes	two
T2060	3008-3010	,	denotes	,
T2061	3010-3018	NN	denotes	trTACC1A
T2062	3019-3022	CC	denotes	and
T2063	3023-3031	NN	denotes	trTACC1B
T2064	3036-3043	RB	denotes	clearly
T2065	3044-3048	RBS	denotes	most
T2066	3049-3056	JJ	denotes	related
T2067	3057-3059	IN	denotes	to
T2068	3060-3065	NN	denotes	TACC1
T2069	3066-3067	-LRB-	denotes	(
T2070	3067-3071	NN	denotes	Fig.
T2071	3072-3073	CD	denotes	1
T2072	3073-3074	-RRB-	denotes	)
T2073	3074-3075	.	denotes	.
T2074	3075-3189	sentence	denotes	Although trTACC1A is highly homologous to trTACC1B, the latter encodes a significantly smaller predicted protein.
T2075	3076-3084	IN	denotes	Although
T2076	3094-3096	VBZ	denotes	is
T2077	3085-3093	NN	denotes	trTACC1A
T2078	3139-3146	VBZ	denotes	encodes
T2079	3097-3103	RB	denotes	highly
T2080	3104-3114	JJ	denotes	homologous
T2081	3115-3117	IN	denotes	to
T2082	3118-3126	NN	denotes	trTACC1B
T2083	3126-3128	,	denotes	,
T2084	3128-3131	DT	denotes	the
T2085	3132-3138	JJ	denotes	latter
T2086	3147-3148	DT	denotes	a
T2087	3181-3188	NN	denotes	protein
T2088	3149-3162	RB	denotes	significantly
T2089	3163-3170	JJR	denotes	smaller
T2090	3171-3180	VBN	denotes	predicted
T2091	3188-3189	.	denotes	.
T2092	3189-3296	sentence	denotes	The trTACC1B gene is encoded by 15 exons over approximately 7 kb of the Takifugu Scaffold 191 (see below).
T2093	3190-3193	DT	denotes	The
T2094	3203-3207	NN	denotes	gene
T2095	3194-3202	NN	denotes	trTACC1B
T2096	3211-3218	VBN	denotes	encoded
T2097	3208-3210	VBZ	denotes	is
T2098	3219-3221	IN	denotes	by
T2099	3222-3224	CD	denotes	15
T2100	3225-3230	NNS	denotes	exons
T2101	3231-3235	IN	denotes	over
T2102	3236-3249	RB	denotes	approximately
T2103	3250-3251	CD	denotes	7
T2104	3252-3254	NN	denotes	kb
T2105	3255-3257	IN	denotes	of
T2106	3258-3261	DT	denotes	the
T2107	3271-3279	NNP	denotes	Scaffold
T2108	3262-3270	NNP	denotes	Takifugu
T2109	3280-3283	CD	denotes	191
T2110	3284-3285	-LRB-	denotes	(
T2111	3285-3288	VB	denotes	see
T2112	3289-3294	RB	denotes	below
T2113	3294-3295	-RRB-	denotes	)
T2114	3295-3296	.	denotes	.
T2115	3296-3437	sentence	denotes	A search of this region using the trTACC1A sequence and gene prediction software has so far failed to identify additional exons of trTACC1B.
T2116	3297-3298	DT	denotes	A
T2117	3299-3305	NN	denotes	search
T2118	3389-3395	VBN	denotes	failed
T2119	3306-3308	IN	denotes	of
T2120	3309-3313	DT	denotes	this
T2121	3314-3320	NN	denotes	region
T2122	3321-3326	VBG	denotes	using
T2123	3327-3330	DT	denotes	the
T2124	3369-3377	NN	denotes	software
T2125	3331-3339	NN	denotes	trTACC1A
T2126	3340-3348	NN	denotes	sequence
T2127	3349-3352	CC	denotes	and
T2128	3353-3357	NN	denotes	gene
T2129	3358-3368	NN	denotes	prediction
T2130	3378-3381	VBZ	denotes	has
T2131	3382-3384	RB	denotes	so
T2132	3385-3388	RB	denotes	far
T2133	3396-3398	TO	denotes	to
T2134	3399-3407	VB	denotes	identify
T2135	3408-3418	JJ	denotes	additional
T2136	3419-3424	NNS	denotes	exons
T2137	3425-3427	IN	denotes	of
T2138	3428-3436	NN	denotes	trTACC1B
T2139	3436-3437	.	denotes	.
T2140	3437-3734	sentence	denotes	However, given the intron/exon structure of this apparently complete gene, it appears likely that trTACC1B is active in the pufferfish, and presumably fulfils either a temporal-spatial specific function within the organism, or a distinct function from the larger trTACC1A product within the cell.
T2141	3438-3445	RB	denotes	However
T2142	3516-3523	VBZ	denotes	appears
T2143	3445-3447	,	denotes	,
T2144	3447-3452	VBN	denotes	given
T2145	3453-3456	DT	denotes	the
T2146	3469-3478	NN	denotes	structure
T2147	3457-3463	NN	denotes	intron
T2148	3464-3468	NN	denotes	exon
T2149	3463-3464	HYPH	denotes	/
T2150	3479-3481	IN	denotes	of
T2151	3482-3486	DT	denotes	this
T2152	3507-3511	NN	denotes	gene
T2153	3487-3497	RB	denotes	apparently
T2154	3498-3506	JJ	denotes	complete
T2155	3511-3513	,	denotes	,
T2156	3513-3515	PRP	denotes	it
T2157	3524-3530	JJ	denotes	likely
T2158	3531-3535	IN	denotes	that
T2159	3545-3547	VBZ	denotes	is
T2160	3536-3544	NN	denotes	trTACC1B
T2161	3548-3554	JJ	denotes	active
T2162	3555-3557	IN	denotes	in
T2163	3558-3561	DT	denotes	the
T2164	3562-3572	NN	denotes	pufferfish
T2165	3572-3574	,	denotes	,
T2166	3574-3577	CC	denotes	and
T2167	3578-3588	RB	denotes	presumably
T2168	3589-3596	VBZ	denotes	fulfils
T2169	3597-3603	CC	denotes	either
T2170	3632-3640	NN	denotes	function
T2171	3604-3605	DT	denotes	a
T2172	3606-3614	JJ	denotes	temporal
T2173	3615-3622	JJ	denotes	spatial
T2174	3614-3615	HYPH	denotes	-
T2175	3623-3631	JJ	denotes	specific
T2176	3641-3647	IN	denotes	within
T2177	3648-3651	DT	denotes	the
T2178	3652-3660	NN	denotes	organism
T2179	3660-3662	,	denotes	,
T2180	3662-3664	CC	denotes	or
T2181	3665-3666	DT	denotes	a
T2182	3676-3684	NN	denotes	function
T2183	3667-3675	JJ	denotes	distinct
T2184	3685-3689	IN	denotes	from
T2185	3690-3693	DT	denotes	the
T2186	3710-3717	NN	denotes	product
T2187	3694-3700	JJR	denotes	larger
T2188	3701-3709	NN	denotes	trTACC1A
T2189	3718-3724	IN	denotes	within
T2190	3725-3728	DT	denotes	the
T2191	3729-3733	NN	denotes	cell
T2192	3733-3734	.	denotes	.
T2193	3734-4026	sentence	denotes	Thus, based upon the surrounding chromosomal loci (see below), the trTACC1A and trTACC1B genes appear to have arisen from the duplication of the chromosomal segment containing the teleost TACC1 ancestor, during the additional partial genomic duplication that occurred in the teleost lineage.
T2194	3735-3739	RB	denotes	Thus
T2195	3830-3836	VBP	denotes	appear
T2196	3739-3741	,	denotes	,
T2197	3741-3746	VBN	denotes	based
T2198	3747-3751	IN	denotes	upon
T2199	3752-3755	DT	denotes	the
T2200	3780-3784	NNS	denotes	loci
T2201	3756-3767	VBG	denotes	surrounding
T2202	3768-3779	JJ	denotes	chromosomal
T2203	3785-3786	-LRB-	denotes	(
T2204	3786-3789	VB	denotes	see
T2205	3790-3795	RB	denotes	below
T2206	3795-3796	-RRB-	denotes	)
T2207	3796-3798	,	denotes	,
T2208	3798-3801	DT	denotes	the
T2209	3824-3829	NNS	denotes	genes
T2210	3802-3810	NN	denotes	trTACC1A
T2211	3811-3814	CC	denotes	and
T2212	3815-3823	NN	denotes	trTACC1B
T2213	3837-3839	TO	denotes	to
T2214	3845-3851	VBN	denotes	arisen
T2215	3840-3844	VB	denotes	have
T2216	3852-3856	IN	denotes	from
T2217	3857-3860	DT	denotes	the
T2218	3861-3872	NN	denotes	duplication
T2219	3873-3875	IN	denotes	of
T2220	3876-3879	DT	denotes	the
T2221	3892-3899	NN	denotes	segment
T2222	3880-3891	JJ	denotes	chromosomal
T2223	3900-3910	VBG	denotes	containing
T2224	3911-3914	DT	denotes	the
T2225	3929-3937	NN	denotes	ancestor
T2226	3915-3922	NN	denotes	teleost
T2227	3923-3928	NN	denotes	TACC1
T2228	3937-3939	,	denotes	,
T2229	3939-3945	IN	denotes	during
T2230	3946-3949	DT	denotes	the
T2231	3977-3988	NN	denotes	duplication
T2232	3950-3960	JJ	denotes	additional
T2233	3961-3968	JJ	denotes	partial
T2234	3969-3976	JJ	denotes	genomic
T2235	3989-3993	WDT	denotes	that
T2236	3994-4002	VBD	denotes	occurred
T2237	4003-4005	IN	denotes	in
T2238	4006-4009	DT	denotes	the
T2239	4018-4025	NN	denotes	lineage
T2240	4010-4017	NN	denotes	teleost
T2241	4025-4026	.	denotes	.
T2242	4026-4213	sentence	denotes	Therefore, this analysis of T. rubripes does not support the hypothesis that the region surrounding the TACC3 ancestor was included in the second round of vertebrate genomic duplication.
T2243	4027-4036	RB	denotes	Therefore
T2244	4076-4083	VB	denotes	support
T2245	4036-4038	,	denotes	,
T2246	4038-4042	DT	denotes	this
T2247	4043-4051	NN	denotes	analysis
T2248	4052-4054	IN	denotes	of
T2249	4055-4057	NNP	denotes	T.
T2250	4058-4066	NNP	denotes	rubripes
T2251	4067-4071	VBZ	denotes	does
T2252	4072-4075	RB	denotes	not
T2253	4084-4087	DT	denotes	the
T2254	4088-4098	NN	denotes	hypothesis
T2255	4099-4103	IN	denotes	that
T2256	4150-4158	VBN	denotes	included
T2257	4104-4107	DT	denotes	the
T2258	4108-4114	NN	denotes	region
T2259	4115-4126	VBG	denotes	surrounding
T2260	4127-4130	DT	denotes	the
T2261	4137-4145	NN	denotes	ancestor
T2262	4131-4136	NN	denotes	TACC3
T2263	4146-4149	VBD	denotes	was
T2264	4159-4161	IN	denotes	in
T2265	4162-4165	DT	denotes	the
T2266	4173-4178	NN	denotes	round
T2267	4166-4172	JJ	denotes	second
T2268	4179-4181	IN	denotes	of
T2269	4182-4192	NN	denotes	vertebrate
T2270	4201-4212	NN	denotes	duplication
T2271	4193-4200	JJ	denotes	genomic
T2272	4212-4213	.	denotes	.
T2273	4213-4421	sentence	denotes	Examination of higher vertebrates led to the identification of splice variants of TACC1 and TACC2 in Mus musculus, and the assembly of the previously unidentified orthologues of TACC1-3 from Rattus norvegus.
T2274	4214-4225	NN	denotes	Examination
T2275	4248-4251	VBD	denotes	led
T2276	4226-4228	IN	denotes	of
T2277	4229-4235	JJR	denotes	higher
T2278	4236-4247	NNS	denotes	vertebrates
T2279	4252-4254	IN	denotes	to
T2280	4255-4258	DT	denotes	the
T2281	4259-4273	NN	denotes	identification
T2282	4274-4276	IN	denotes	of
T2283	4277-4283	NN	denotes	splice
T2284	4284-4292	NNS	denotes	variants
T2285	4293-4295	IN	denotes	of
T2286	4296-4301	NN	denotes	TACC1
T2287	4302-4305	CC	denotes	and
T2288	4306-4311	NN	denotes	TACC2
T2289	4312-4314	IN	denotes	in
T2290	4315-4318	NNP	denotes	Mus
T2291	4319-4327	NNP	denotes	musculus
T2292	4327-4329	,	denotes	,
T2293	4329-4332	CC	denotes	and
T2294	4333-4336	DT	denotes	the
T2295	4337-4345	NN	denotes	assembly
T2296	4346-4348	IN	denotes	of
T2297	4349-4352	DT	denotes	the
T2298	4377-4388	NNS	denotes	orthologues
T2299	4353-4363	RB	denotes	previously
T2300	4364-4376	JJ	denotes	unidentified
T2301	4389-4391	IN	denotes	of
T2302	4392-4397	NN	denotes	TACC1
T2303	4397-4398	HYPH	denotes	-
T2304	4398-4399	CD	denotes	3
T2305	4400-4404	IN	denotes	from
T2306	4405-4411	NN	denotes	Rattus
T2307	4412-4420	NN	denotes	norvegus
T2308	4420-4421	.	denotes	.
T2309	4421-4487	sentence	denotes	In addition, the TACC1X sequence was found on mouse chromosome X.
T2310	4422-4424	IN	denotes	In
T2311	4459-4464	VBN	denotes	found
T2312	4425-4433	NN	denotes	addition
T2313	4433-4435	,	denotes	,
T2314	4435-4438	DT	denotes	the
T2315	4446-4454	NN	denotes	sequence
T2316	4439-4445	NN	denotes	TACC1X
T2317	4455-4458	VBD	denotes	was
T2318	4465-4467	IN	denotes	on
T2319	4468-4473	NN	denotes	mouse
T2320	4485-4486	NN	denotes	X
T2321	4474-4484	NN	denotes	chromosome
T2322	4486-4487	.	denotes	.
T2323	4487-4644	sentence	denotes	This gene is clearly related to the mouse TACC1, however, further examination revealed a mouse B1 repeat distributed over the length of the proposed intron.
T2324	4488-4492	DT	denotes	This
T2325	4493-4497	NN	denotes	gene
T2326	4509-4516	VBN	denotes	related
T2327	4498-4500	VBZ	denotes	is
T2328	4501-4508	RB	denotes	clearly
T2329	4566-4574	VBD	denotes	revealed
T2330	4517-4519	IN	denotes	to
T2331	4520-4523	DT	denotes	the
T2332	4530-4535	NN	denotes	TACC1
T2333	4524-4529	NN	denotes	mouse
T2334	4535-4537	,	denotes	,
T2335	4537-4544	RB	denotes	however
T2336	4544-4546	,	denotes	,
T2337	4546-4553	JJ	denotes	further
T2338	4554-4565	NN	denotes	examination
T2339	4575-4576	DT	denotes	a
T2340	4586-4592	NN	denotes	repeat
T2341	4577-4582	NN	denotes	mouse
T2342	4583-4585	NN	denotes	B1
T2343	4593-4604	VBN	denotes	distributed
T2344	4605-4609	IN	denotes	over
T2345	4610-4613	DT	denotes	the
T2346	4614-4620	NN	denotes	length
T2347	4621-4623	IN	denotes	of
T2348	4624-4627	DT	denotes	the
T2349	4637-4643	NN	denotes	intron
T2350	4628-4636	VBN	denotes	proposed
T2351	4643-4644	.	denotes	.
T2352	4644-4801	sentence	denotes	In addition, no expression of TACC1X was detected in mouse RNA by rt-PCR analysis (data not shown), suggesting that this sequence is a processed pseudogene.
T2353	4645-4647	IN	denotes	In
T2354	4686-4694	VBN	denotes	detected
T2355	4648-4656	NN	denotes	addition
T2356	4656-4658	,	denotes	,
T2357	4658-4660	DT	denotes	no
T2358	4661-4671	NN	denotes	expression
T2359	4672-4674	IN	denotes	of
T2360	4675-4681	NN	denotes	TACC1X
T2361	4682-4685	VBD	denotes	was
T2362	4695-4697	IN	denotes	in
T2363	4698-4703	NN	denotes	mouse
T2364	4704-4707	NN	denotes	RNA
T2365	4708-4710	IN	denotes	by
T2366	4711-4713	NN	denotes	rt
T2367	4714-4717	NN	denotes	PCR
T2368	4713-4714	HYPH	denotes	-
T2369	4718-4726	NN	denotes	analysis
T2370	4727-4728	-LRB-	denotes	(
T2371	4737-4742	VBN	denotes	shown
T2372	4728-4732	NNS	denotes	data
T2373	4733-4736	RB	denotes	not
T2374	4742-4743	-RRB-	denotes	)
T2375	4743-4745	,	denotes	,
T2376	4745-4755	VBG	denotes	suggesting
T2377	4756-4760	IN	denotes	that
T2378	4775-4777	VBZ	denotes	is
T2379	4761-4765	DT	denotes	this
T2380	4766-4774	NN	denotes	sequence
T2381	4778-4779	DT	denotes	a
T2382	4790-4800	NN	denotes	pseudogene
T2383	4780-4789	VBN	denotes	processed
T2384	4800-4801	.	denotes	.
T2385	4801-5010	sentence	denotes	Similarly, TACC1 pseudogenes also exist spread over 22 kb of the centromeric region of human chromosome 10 and, in 8q21, a shorter region 86% identical to the final 359 bp of the TACC1 3' untranslated region.
T2386	4802-4811	RB	denotes	Similarly
T2387	4836-4841	VBP	denotes	exist
T2388	4811-4813	,	denotes	,
T2389	4813-4818	NN	denotes	TACC1
T2390	4819-4830	NNS	denotes	pseudogenes
T2391	4831-4835	RB	denotes	also
T2392	4842-4848	VBN	denotes	spread
T2393	4849-4853	IN	denotes	over
T2394	4854-4856	CD	denotes	22
T2395	4857-4859	NN	denotes	kb
T2396	4860-4862	IN	denotes	of
T2397	4863-4866	DT	denotes	the
T2398	4879-4885	NN	denotes	region
T2399	4867-4878	JJ	denotes	centromeric
T2400	4886-4888	IN	denotes	of
T2401	4889-4894	JJ	denotes	human
T2402	4895-4905	NN	denotes	chromosome
T2403	4906-4908	CD	denotes	10
T2404	4909-4912	CC	denotes	and
T2405	4912-4914	,	denotes	,
T2406	4914-4916	IN	denotes	in
T2407	4917-4921	NN	denotes	8q21
T2408	4921-4923	,	denotes	,
T2409	4923-4924	DT	denotes	a
T2410	4933-4939	NN	denotes	region
T2411	4925-4932	JJR	denotes	shorter
T2412	4940-4942	CD	denotes	86
T2413	4942-4943	NN	denotes	%
T2414	4944-4953	JJ	denotes	identical
T2415	4954-4956	IN	denotes	to
T2416	4957-4960	DT	denotes	the
T2417	4971-4973	NN	denotes	bp
T2418	4961-4966	JJ	denotes	final
T2419	4967-4970	CD	denotes	359
T2420	4974-4976	IN	denotes	of
T2421	4977-4980	DT	denotes	the
T2422	5003-5009	NN	denotes	region
T2423	4981-4986	NN	denotes	TACC1
T2424	4987-4988	CD	denotes	3
T2425	4988-4989	SYM	denotes	'
T2426	4990-5002	JJ	denotes	untranslated
T2427	5009-5010	.	denotes	.
T2428	5010-5099	sentence	denotes	No pseudogenes corresponding to TACC2 or TACC3 were identified in any mammalian species.
T2429	5011-5013	DT	denotes	No
T2430	5014-5025	NNS	denotes	pseudogenes
T2431	5063-5073	VBN	denotes	identified
T2432	5026-5039	VBG	denotes	corresponding
T2433	5040-5042	IN	denotes	to
T2434	5043-5048	NN	denotes	TACC2
T2435	5049-5051	CC	denotes	or
T2436	5052-5057	NN	denotes	TACC3
T2437	5058-5062	VBD	denotes	were
T2438	5074-5076	IN	denotes	in
T2439	5077-5080	DT	denotes	any
T2440	5091-5098	NNS	denotes	species
T2441	5081-5090	JJ	denotes	mammalian
T2442	5098-5099	.	denotes	.
T13814	27928-27929	.	denotes	.
T2677	5101-5117	NN	denotes	Characterization
T2678	5118-5120	IN	denotes	of
T2679	5121-5131	NN	denotes	vertebrate
T2680	5132-5137	NN	denotes	TACC3
T2681	5138-5149	NNS	denotes	orthologues
T2682	5149-5335	sentence	denotes	Based upon current functional analysis, the characterization of TACC3 orthologues is likely to be pivotal to understanding the sequence and functional evolution of the TACC gene family.
T2683	5150-5155	VBN	denotes	Based
T2684	5232-5234	VBZ	denotes	is
T2685	5156-5160	IN	denotes	upon
T2686	5161-5168	JJ	denotes	current
T2687	5180-5188	NN	denotes	analysis
T2688	5169-5179	JJ	denotes	functional
T2689	5188-5190	,	denotes	,
T2690	5190-5193	DT	denotes	the
T2691	5194-5210	NN	denotes	characterization
T2692	5211-5213	IN	denotes	of
T2693	5214-5219	NN	denotes	TACC3
T2694	5220-5231	NNS	denotes	orthologues
T2695	5235-5241	JJ	denotes	likely
T2696	5242-5244	TO	denotes	to
T2697	5245-5247	VB	denotes	be
T2698	5248-5255	JJ	denotes	pivotal
T2699	5256-5258	IN	denotes	to
T2700	5259-5272	VBG	denotes	understanding
T2701	5273-5276	DT	denotes	the
T2702	5277-5285	NN	denotes	sequence
T2703	5286-5289	CC	denotes	and
T2704	5290-5300	JJ	denotes	functional
T2705	5301-5310	NN	denotes	evolution
T2706	5311-5313	IN	denotes	of
T2707	5314-5317	DT	denotes	the
T2708	5328-5334	NN	denotes	family
T2709	5318-5322	NN	denotes	TACC
T2710	5323-5327	NN	denotes	gene
T2711	5334-5335	.	denotes	.
T2712	5335-5464	sentence	denotes	As indicated below, the chromosomal region containing the TACC gene precursors was duplicated twice during vertebrate evolution.
T2713	5336-5338	IN	denotes	As
T2714	5339-5348	VBN	denotes	indicated
T2715	5419-5429	VBN	denotes	duplicated
T2716	5349-5354	RB	denotes	below
T2717	5354-5356	,	denotes	,
T2718	5356-5359	DT	denotes	the
T2719	5372-5378	NN	denotes	region
T2720	5360-5371	JJ	denotes	chromosomal
T2721	5379-5389	VBG	denotes	containing
T2722	5390-5393	DT	denotes	the
T2723	5404-5414	NNS	denotes	precursors
T2724	5394-5398	NN	denotes	TACC
T2725	5399-5403	NN	denotes	gene
T2726	5415-5418	VBD	denotes	was
T2727	5430-5435	RB	denotes	twice
T2728	5436-5442	IN	denotes	during
T2729	5443-5453	NN	denotes	vertebrate
T2730	5454-5463	NN	denotes	evolution
T2731	5463-5464	.	denotes	.
T2732	5464-5736	sentence	denotes	Although the analysis of T. rubripes, rodents and humans so far suggests that the vertebrate TACC3 precursor was not included in the second round of genomic duplication, it could not be excluded that a TACC4 gene may have been lost during the evolution of these lineages.
T2733	5465-5473	IN	denotes	Although
T2734	5529-5537	VBZ	denotes	suggests
T2735	5474-5477	DT	denotes	the
T2736	5478-5486	NN	denotes	analysis
T2737	5487-5489	IN	denotes	of
T2738	5490-5492	NNP	denotes	T.
T2739	5493-5501	NNP	denotes	rubripes
T2740	5501-5503	,	denotes	,
T2741	5503-5510	NNS	denotes	rodents
T2742	5511-5514	CC	denotes	and
T2743	5515-5521	NNS	denotes	humans
T2744	5522-5524	RB	denotes	so
T2745	5525-5528	RB	denotes	far
T2746	5651-5659	VBN	denotes	excluded
T2747	5538-5542	IN	denotes	that
T2748	5582-5590	VBN	denotes	included
T2749	5543-5546	DT	denotes	the
T2750	5564-5573	NN	denotes	precursor
T2751	5547-5557	NN	denotes	vertebrate
T2752	5558-5563	NN	denotes	TACC3
T2753	5574-5577	VBD	denotes	was
T2754	5578-5581	RB	denotes	not
T2755	5591-5593	IN	denotes	in
T2756	5594-5597	DT	denotes	the
T2757	5605-5610	NN	denotes	round
T2758	5598-5604	JJ	denotes	second
T2759	5611-5613	IN	denotes	of
T2760	5614-5621	JJ	denotes	genomic
T2761	5622-5633	NN	denotes	duplication
T2762	5633-5635	,	denotes	,
T2763	5635-5637	PRP	denotes	it
T2764	5638-5643	MD	denotes	could
T2765	5644-5647	RB	denotes	not
T2766	5648-5650	VB	denotes	be
T2767	5660-5664	IN	denotes	that
T2768	5692-5696	VBN	denotes	lost
T2769	5665-5666	DT	denotes	a
T2770	5673-5677	NN	denotes	gene
T2771	5667-5672	NN	denotes	TACC4
T2772	5678-5681	MD	denotes	may
T2773	5682-5686	VB	denotes	have
T2774	5687-5691	VBN	denotes	been
T2775	5697-5703	IN	denotes	during
T2776	5704-5707	DT	denotes	the
T2777	5708-5717	NN	denotes	evolution
T2778	5718-5720	IN	denotes	of
T2779	5721-5726	DT	denotes	these
T2780	5727-5735	NNS	denotes	lineages
T2781	5735-5736	.	denotes	.
T2782	5736-5843	sentence	denotes	The cloning of a new member of the TACC family in Oryctolagus cuniculus has added to this controversy [9].
T2783	5737-5740	DT	denotes	The
T2784	5741-5748	NN	denotes	cloning
T2785	5813-5818	VBN	denotes	added
T2786	5749-5751	IN	denotes	of
T2787	5752-5753	DT	denotes	a
T2788	5758-5764	NN	denotes	member
T2789	5754-5757	JJ	denotes	new
T2790	5765-5767	IN	denotes	of
T2791	5768-5771	DT	denotes	the
T2792	5777-5783	NN	denotes	family
T2793	5772-5776	NN	denotes	TACC
T2794	5784-5786	IN	denotes	in
T2795	5787-5798	NNP	denotes	Oryctolagus
T2796	5799-5808	NNP	denotes	cuniculus
T2797	5809-5812	VBZ	denotes	has
T2798	5819-5821	IN	denotes	to
T2799	5822-5826	DT	denotes	this
T2800	5827-5838	NN	denotes	controversy
T2801	5839-5840	-LRB-	denotes	[
T2802	5840-5841	CD	denotes	9
T2803	5841-5842	-RRB-	denotes	]
T2804	5842-5843	.	denotes	.
T2805	5843-5937	sentence	denotes	Designated TACC4, the 1.5 kb cDNA was highly related, but proposed to be distinct from TACC3.
T2806	5844-5854	VBN	denotes	Designated
T2807	5878-5881	VBD	denotes	was
T2808	5855-5860	NN	denotes	TACC4
T2809	5860-5862	,	denotes	,
T2810	5862-5865	DT	denotes	the
T2811	5873-5877	NN	denotes	cDNA
T2812	5866-5869	CD	denotes	1.5
T2813	5870-5872	NN	denotes	kb
T2814	5882-5888	RB	denotes	highly
T2815	5889-5896	VBN	denotes	related
T2816	5896-5898	,	denotes	,
T2817	5898-5901	CC	denotes	but
T2818	5902-5910	VBN	denotes	proposed
T2819	5911-5913	TO	denotes	to
T2820	5914-5916	VB	denotes	be
T2821	5917-5925	JJ	denotes	distinct
T2822	5926-5930	IN	denotes	from
T2823	5931-5936	NN	denotes	TACC3
T2824	5936-5937	.	denotes	.
T2825	5937-6079	sentence	denotes	However, Northern blot data suggested that this gene produces a single 2.3 kb transcript [9], indicating that the cloned cDNA was incomplete.
T2826	5938-5945	RB	denotes	However
T2827	5966-5975	VBD	denotes	suggested
T2828	5945-5947	,	denotes	,
T2829	5947-5955	NNP	denotes	Northern
T2830	5956-5960	NN	denotes	blot
T2831	5961-5965	NNS	denotes	data
T2832	5976-5980	IN	denotes	that
T2833	5991-5999	VBZ	denotes	produces
T2834	5981-5985	DT	denotes	this
T2835	5986-5990	NN	denotes	gene
T2836	6000-6001	DT	denotes	a
T2837	6016-6026	NN	denotes	transcript
T2838	6002-6008	JJ	denotes	single
T2839	6009-6012	CD	denotes	2.3
T2840	6013-6015	NN	denotes	kb
T2841	6027-6028	-LRB-	denotes	[
T2842	6028-6029	CD	denotes	9
T2843	6029-6030	-RRB-	denotes	]
T2844	6030-6032	,	denotes	,
T2845	6032-6042	VBG	denotes	indicating
T2846	6043-6047	IN	denotes	that
T2847	6064-6067	VBD	denotes	was
T2848	6048-6051	DT	denotes	the
T2849	6059-6063	NN	denotes	cDNA
T2850	6052-6058	VBN	denotes	cloned
T2851	6068-6078	JJ	denotes	incomplete
T2852	6078-6079	.	denotes	.
T2853	6079-6231	sentence	denotes	The degree of similarity to the published sequence of human and mouse TACC3 suggested to us that TACC4 actually represents a partial rabbit TACC3 cDNA.
T2854	6080-6083	DT	denotes	The
T2855	6084-6090	NN	denotes	degree
T2856	6156-6165	VBD	denotes	suggested
T2857	6091-6093	IN	denotes	of
T2858	6094-6104	NN	denotes	similarity
T2859	6105-6107	IN	denotes	to
T2860	6108-6111	DT	denotes	the
T2861	6122-6130	NN	denotes	sequence
T2862	6112-6121	VBN	denotes	published
T2863	6131-6133	IN	denotes	of
T2864	6134-6139	JJ	denotes	human
T2865	6150-6155	NN	denotes	TACC3
T2866	6140-6143	CC	denotes	and
T2867	6144-6149	NN	denotes	mouse
T2868	6166-6168	IN	denotes	to
T2869	6169-6171	PRP	denotes	us
T2870	6172-6176	IN	denotes	that
T2871	6192-6202	VBZ	denotes	represents
T2872	6177-6182	NN	denotes	TACC4
T2873	6183-6191	RB	denotes	actually
T2874	6203-6204	DT	denotes	a
T2875	6226-6230	NN	denotes	cDNA
T2876	6205-6212	JJ	denotes	partial
T2877	6213-6219	NN	denotes	rabbit
T2878	6220-6225	NN	denotes	TACC3
T2879	6230-6231	.	denotes	.
T2880	6231-6368	sentence	denotes	To test this hypothesis, we set out to clone the complete rabbit TACC3 sequence, based upon the known features of human and mouse TACC3.
T2881	6232-6234	TO	denotes	To
T2882	6235-6239	VB	denotes	test
T2883	6260-6263	VBD	denotes	set
T2884	6240-6244	DT	denotes	this
T2885	6245-6255	NN	denotes	hypothesis
T2886	6255-6257	,	denotes	,
T2887	6257-6259	PRP	denotes	we
T2888	6264-6267	RP	denotes	out
T2889	6268-6270	TO	denotes	to
T2890	6271-6276	VB	denotes	clone
T2891	6277-6280	DT	denotes	the
T2892	6303-6311	NN	denotes	sequence
T2893	6281-6289	JJ	denotes	complete
T2894	6290-6296	NN	denotes	rabbit
T2895	6297-6302	NN	denotes	TACC3
T2896	6311-6313	,	denotes	,
T2897	6313-6318	VBN	denotes	based
T2898	6319-6323	IN	denotes	upon
T2899	6324-6327	DT	denotes	the
T2900	6334-6342	NNS	denotes	features
T2901	6328-6333	JJ	denotes	known
T2902	6343-6345	IN	denotes	of
T2903	6346-6351	JJ	denotes	human
T2904	6362-6367	NN	denotes	TACC3
T2905	6352-6355	CC	denotes	and
T2906	6356-6361	NN	denotes	mouse
T2907	6367-6368	.	denotes	.
T2908	6368-6513	sentence	denotes	We have previously noted that the N-terminal and C-terminal regions of the human and mouse TACC3 proteins are highly conserved ([2], see below).
T2909	6369-6371	PRP	denotes	We
T2910	6388-6393	VBN	denotes	noted
T2911	6372-6376	VBP	denotes	have
T2912	6377-6387	RB	denotes	previously
T2913	6394-6398	IN	denotes	that
T2914	6475-6478	VBP	denotes	are
T2915	6399-6402	DT	denotes	the
T2916	6429-6436	NNS	denotes	regions
T2917	6403-6404	NN	denotes	N
T2918	6405-6413	JJ	denotes	terminal
T2919	6404-6405	HYPH	denotes	-
T2920	6414-6417	CC	denotes	and
T2921	6418-6419	NN	denotes	C
T2922	6420-6428	JJ	denotes	terminal
T2923	6419-6420	HYPH	denotes	-
T2924	6437-6439	IN	denotes	of
T2925	6440-6443	DT	denotes	the
T2926	6466-6474	NN	denotes	proteins
T2927	6444-6449	JJ	denotes	human
T2928	6450-6453	CC	denotes	and
T2929	6454-6459	NN	denotes	mouse
T2930	6460-6465	NN	denotes	TACC3
T2931	6479-6485	RB	denotes	highly
T2932	6486-6495	VBN	denotes	conserved
T2933	6496-6497	-LRB-	denotes	(
T2934	6498-6499	CD	denotes	2
T2935	6497-6498	-LRB-	denotes	[
T2936	6499-6500	-RRB-	denotes	]
T2937	6500-6502	,	denotes	,
T2938	6502-6505	VBP	denotes	see
T2939	6506-6511	RB	denotes	below
T2940	6511-6512	-RRB-	denotes	)
T2941	6512-6513	.	denotes	.
T2942	6513-6776	sentence	denotes	Therefore, based upon the sequence identity between these genes, we designed a consensus oligonucleotide primer, T3con2, that would be suitable for the identification of the region containing the initiator methionine of the TACC3 cDNAs from primates and rodents.
T2943	6514-6523	RB	denotes	Therefore
T2944	6582-6590	VBD	denotes	designed
T2945	6523-6525	,	denotes	,
T2946	6525-6530	VBN	denotes	based
T2947	6531-6535	IN	denotes	upon
T2948	6536-6539	DT	denotes	the
T2949	6549-6557	NN	denotes	identity
T2950	6540-6548	NN	denotes	sequence
T2951	6558-6565	IN	denotes	between
T2952	6566-6571	DT	denotes	these
T2953	6572-6577	NNS	denotes	genes
T2954	6577-6579	,	denotes	,
T2955	6579-6581	PRP	denotes	we
T2956	6591-6592	DT	denotes	a
T2957	6619-6625	NN	denotes	primer
T2958	6593-6602	NN	denotes	consensus
T2959	6603-6618	NN	denotes	oligonucleotide
T2960	6625-6627	,	denotes	,
T2961	6627-6633	NN	denotes	T3con2
T2962	6633-6635	,	denotes	,
T2963	6635-6639	WDT	denotes	that
T2964	6646-6648	VB	denotes	be
T2965	6640-6645	MD	denotes	would
T2966	6649-6657	JJ	denotes	suitable
T2967	6658-6661	IN	denotes	for
T2968	6662-6665	DT	denotes	the
T2969	6666-6680	NN	denotes	identification
T2970	6681-6683	IN	denotes	of
T2971	6684-6687	DT	denotes	the
T2972	6688-6694	NN	denotes	region
T2973	6695-6705	VBG	denotes	containing
T2974	6706-6709	DT	denotes	the
T2975	6720-6730	NN	denotes	methionine
T2976	6710-6719	NN	denotes	initiator
T2977	6731-6733	IN	denotes	of
T2978	6734-6737	DT	denotes	the
T2979	6744-6749	NNS	denotes	cDNAs
T2980	6738-6743	NN	denotes	TACC3
T2981	6750-6754	IN	denotes	from
T2982	6755-6763	NNS	denotes	primates
T2983	6764-6767	CC	denotes	and
T2984	6768-6775	NNS	denotes	rodents
T2985	6775-6776	.	denotes	.
T2986	6776-6960	sentence	denotes	Using this primer, in combination with the TACC4-specific RACE primer (RACE2), initially used by Steadman et al [9], we isolated a 1.5 kb PCR product from rabbit brain cDNA by rt-PCR.
T2987	6777-6782	VBG	denotes	Using
T2988	6897-6905	VBN	denotes	isolated
T2989	6783-6787	DT	denotes	this
T2990	6788-6794	NN	denotes	primer
T2991	6794-6796	,	denotes	,
T2992	6796-6798	IN	denotes	in
T2993	6799-6810	NN	denotes	combination
T2994	6811-6815	IN	denotes	with
T2995	6816-6819	DT	denotes	the
T2996	6840-6846	NN	denotes	primer
T2997	6820-6825	NN	denotes	TACC4
T2998	6826-6834	JJ	denotes	specific
T2999	6825-6826	HYPH	denotes	-
T3000	6835-6839	NN	denotes	RACE
T3001	6847-6848	-LRB-	denotes	(
T3002	6848-6853	NN	denotes	RACE2
T3003	6853-6854	-RRB-	denotes	)
T3004	6854-6856	,	denotes	,
T3005	6856-6865	RB	denotes	initially
T3006	6866-6870	VBN	denotes	used
T3007	6871-6873	IN	denotes	by
T3008	6874-6882	NNP	denotes	Steadman
T3009	6883-6885	FW	denotes	et
T3010	6886-6888	FW	denotes	al
T3011	6889-6890	-LRB-	denotes	[
T3012	6890-6891	CD	denotes	9
T3013	6891-6892	-RRB-	denotes	]
T3014	6892-6894	,	denotes	,
T3015	6894-6896	PRP	denotes	we
T3016	6906-6907	DT	denotes	a
T3017	6919-6926	NN	denotes	product
T3018	6908-6911	CD	denotes	1.5
T3019	6912-6914	NN	denotes	kb
T3020	6915-6918	NN	denotes	PCR
T3021	6927-6931	IN	denotes	from
T3022	6932-6938	NN	denotes	rabbit
T3023	6945-6949	NN	denotes	cDNA
T3024	6939-6944	NN	denotes	brain
T3025	6950-6952	IN	denotes	by
T3026	6953-6955	NN	denotes	rt
T3027	6956-6959	NN	denotes	PCR
T3028	6955-6956	HYPH	denotes	-
T3029	6959-6960	.	denotes	.
T3030	6960-7159	sentence	denotes	In combination with 3'RACE, this generated a consensus cDNA of 2283 bp which corresponds to the transcript size of 2.3 kb detected by the "TACC4" sequence reported in Figure 4 of Steadman et al [9].
T3031	6961-6963	IN	denotes	In
T3032	6994-7003	VBD	denotes	generated
T3033	6964-6975	NN	denotes	combination
T3034	6976-6980	IN	denotes	with
T3035	6981-6982	CD	denotes	3
T3036	6983-6987	NN	denotes	RACE
T3037	6982-6983	SYM	denotes	'
T3038	6987-6989	,	denotes	,
T3039	6989-6993	DT	denotes	this
T3040	7004-7005	DT	denotes	a
T3041	7016-7020	NN	denotes	cDNA
T3042	7006-7015	NN	denotes	consensus
T3043	7021-7023	IN	denotes	of
T3044	7024-7028	CD	denotes	2283
T3045	7029-7031	NN	denotes	bp
T3046	7032-7037	WDT	denotes	which
T3047	7038-7049	VBZ	denotes	corresponds
T3048	7050-7052	IN	denotes	to
T3049	7053-7056	DT	denotes	the
T3050	7068-7072	NN	denotes	size
T3051	7057-7067	NN	denotes	transcript
T3052	7073-7075	IN	denotes	of
T3053	7076-7079	CD	denotes	2.3
T3054	7080-7082	NN	denotes	kb
T3055	7083-7091	VBN	denotes	detected
T3056	7092-7094	IN	denotes	by
T3057	7095-7098	DT	denotes	the
T3058	7107-7115	NN	denotes	sequence
T3059	7099-7100	``	denotes	"
T3060	7100-7105	NN	denotes	TACC4
T3061	7105-7106	''	denotes	"
T3062	7116-7124	VBN	denotes	reported
T3063	7125-7127	IN	denotes	in
T3064	7128-7134	NN	denotes	Figure
T3065	7135-7136	CD	denotes	4
T3066	7137-7139	IN	denotes	of
T3067	7140-7148	NNP	denotes	Steadman
T3068	7149-7151	FW	denotes	et
T3069	7152-7154	FW	denotes	al
T3070	7155-7156	-LRB-	denotes	[
T3071	7156-7157	CD	denotes	9
T3072	7157-7158	-RRB-	denotes	]
T3073	7158-7159	.	denotes	.
T3074	7159-7491	sentence	denotes	Thus, while it remains possible that the "TACC4" sequence is an alternative splice product, or is the product of reduplication of the TACC3 gene (events that would be specific to the rabbit), the only transcript detected in rabbit RNA corresponds to the predicted transcript size of the TACC3 sequence that we have identified here.
T3075	7160-7164	RB	denotes	Thus
T3076	7395-7406	VBZ	denotes	corresponds
T3077	7164-7166	,	denotes	,
T3078	7166-7171	IN	denotes	while
T3079	7175-7182	VBZ	denotes	remains
T3080	7172-7174	PRP	denotes	it
T3081	7183-7191	JJ	denotes	possible
T3082	7192-7196	IN	denotes	that
T3083	7218-7220	VBZ	denotes	is
T3084	7197-7200	DT	denotes	the
T3085	7209-7217	NN	denotes	sequence
T3086	7201-7202	``	denotes	"
T3087	7202-7207	NN	denotes	TACC4
T3088	7207-7208	''	denotes	"
T3089	7221-7223	DT	denotes	an
T3090	7243-7250	NN	denotes	product
T3091	7224-7235	JJ	denotes	alternative
T3092	7236-7242	NN	denotes	splice
T3093	7250-7252	,	denotes	,
T3094	7252-7254	CC	denotes	or
T3095	7255-7257	VBZ	denotes	is
T3096	7258-7261	DT	denotes	the
T3097	7262-7269	NN	denotes	product
T3098	7270-7272	IN	denotes	of
T3099	7273-7286	NN	denotes	reduplication
T3100	7287-7289	IN	denotes	of
T3101	7290-7293	DT	denotes	the
T3102	7300-7304	NN	denotes	gene
T3103	7294-7299	NN	denotes	TACC3
T3104	7305-7306	-LRB-	denotes	(
T3105	7306-7312	NNS	denotes	events
T3106	7313-7317	WDT	denotes	that
T3107	7324-7326	VB	denotes	be
T3108	7318-7323	MD	denotes	would
T3109	7327-7335	JJ	denotes	specific
T3110	7336-7338	IN	denotes	to
T3111	7339-7342	DT	denotes	the
T3112	7343-7349	NN	denotes	rabbit
T3113	7349-7350	-RRB-	denotes	)
T3114	7350-7352	,	denotes	,
T3115	7352-7355	DT	denotes	the
T3116	7361-7371	NN	denotes	transcript
T3117	7356-7360	JJ	denotes	only
T3118	7372-7380	VBN	denotes	detected
T3119	7381-7383	IN	denotes	in
T3120	7384-7390	NN	denotes	rabbit
T3121	7391-7394	NN	denotes	RNA
T3122	7407-7409	IN	denotes	to
T3123	7410-7413	DT	denotes	the
T3124	7435-7439	NN	denotes	size
T3125	7414-7423	VBN	denotes	predicted
T3126	7424-7434	NN	denotes	transcript
T3127	7440-7442	IN	denotes	of
T3128	7443-7446	DT	denotes	the
T3129	7453-7461	NN	denotes	sequence
T3130	7447-7452	NN	denotes	TACC3
T3131	7462-7466	WDT	denotes	that
T3132	7475-7485	VBN	denotes	identified
T3133	7467-7469	PRP	denotes	we
T3134	7470-7474	VBP	denotes	have
T3135	7486-7490	RB	denotes	here
T3136	7490-7491	.	denotes	.
T3137	7491-7794	sentence	denotes	Furthermore, the string of nucleotides found at the 5' end of the "TACC4" sequence is also found at the 5' ends of a number of cDNA sequences (e.g. U82468, NM_023500), that were isolated by 5'RACE, suggesting that they may correspond to an artefact of the 5'RACE methodology used in their construction.
T3138	7492-7503	RB	denotes	Furthermore
T3139	7583-7588	VBN	denotes	found
T3140	7503-7505	,	denotes	,
T3141	7505-7508	DT	denotes	the
T3142	7509-7515	NN	denotes	string
T3143	7516-7518	IN	denotes	of
T3144	7519-7530	NNS	denotes	nucleotides
T3145	7531-7536	VBN	denotes	found
T3146	7537-7539	IN	denotes	at
T3147	7540-7543	DT	denotes	the
T3148	7547-7550	NN	denotes	end
T3149	7544-7545	CD	denotes	5
T3150	7545-7546	SYM	denotes	'
T3151	7551-7553	IN	denotes	of
T3152	7554-7557	DT	denotes	the
T3153	7566-7574	NN	denotes	sequence
T3154	7558-7559	``	denotes	"
T3155	7559-7564	NN	denotes	TACC4
T3156	7564-7565	''	denotes	"
T3157	7575-7577	VBZ	denotes	is
T3158	7578-7582	RB	denotes	also
T3159	7589-7591	IN	denotes	at
T3160	7592-7595	DT	denotes	the
T3161	7599-7603	NNS	denotes	ends
T3162	7596-7597	CD	denotes	5
T3163	7597-7598	SYM	denotes	'
T3164	7604-7606	IN	denotes	of
T3165	7607-7608	DT	denotes	a
T3166	7609-7615	NN	denotes	number
T3167	7616-7618	IN	denotes	of
T3168	7619-7623	NN	denotes	cDNA
T3169	7624-7633	NNS	denotes	sequences
T3170	7634-7635	-LRB-	denotes	(
T3171	7635-7639	FW	denotes	e.g.
T3172	7648-7657	NN	denotes	NM_023500
T3173	7640-7646	NN	denotes	U82468
T3174	7646-7648	,	denotes	,
T3175	7657-7658	-RRB-	denotes	)
T3176	7658-7660	,	denotes	,
T3177	7660-7664	WDT	denotes	that
T3178	7670-7678	VBN	denotes	isolated
T3179	7665-7669	VBD	denotes	were
T3180	7679-7681	IN	denotes	by
T3181	7682-7683	CD	denotes	5
T3182	7684-7688	NN	denotes	RACE
T3183	7683-7684	SYM	denotes	'
T3184	7688-7690	,	denotes	,
T3185	7690-7700	VBG	denotes	suggesting
T3186	7701-7705	IN	denotes	that
T3187	7715-7725	VB	denotes	correspond
T3188	7706-7710	PRP	denotes	they
T3189	7711-7714	MD	denotes	may
T3190	7726-7728	IN	denotes	to
T3191	7729-7731	DT	denotes	an
T3192	7732-7740	NN	denotes	artefact
T3193	7741-7743	IN	denotes	of
T3194	7744-7747	DT	denotes	the
T3195	7755-7766	NN	denotes	methodology
T3196	7748-7749	CD	denotes	5
T3197	7749-7750	SYM	denotes	'
T3198	7750-7754	NN	denotes	RACE
T3199	7767-7771	VBN	denotes	used
T3200	7772-7774	IN	denotes	in
T3201	7775-7780	PRP$	denotes	their
T3202	7781-7793	NN	denotes	construction
T3203	7793-7794	.	denotes	.
T3204	7794-8162	sentence	denotes	The rabbit "TACC4" and the rabbit TACC3 sequence that we have isolated are also found on the same branch of the TACC phylogenetic tree with the other TACC3 orthologues, including maskin (Xenopus laevis), and the newly identified TACC3 sequences in Rattus norvegus, Gallus gallus, Silurana tropicalis, Danio rerio and T. rubripes, reported in this manuscript (Fig. 1).
T3205	7795-7798	DT	denotes	The
T3206	7807-7812	NN	denotes	TACC4
T3207	7799-7805	NN	denotes	rabbit
T3208	7806-7807	``	denotes	"
T3209	7875-7880	VBN	denotes	found
T3210	7812-7813	''	denotes	"
T3211	7814-7817	CC	denotes	and
T3212	7818-7821	DT	denotes	the
T3213	7829-7834	NN	denotes	TACC3
T3214	7822-7828	NN	denotes	rabbit
T3215	7835-7843	NN	denotes	sequence
T3216	7844-7848	WDT	denotes	that
T3217	7857-7865	VBN	denotes	isolated
T3218	7849-7851	PRP	denotes	we
T3219	7852-7856	VBP	denotes	have
T3220	7866-7869	VBP	denotes	are
T3221	7870-7874	RB	denotes	also
T3222	7881-7883	IN	denotes	on
T3223	7884-7887	DT	denotes	the
T3224	7893-7899	NN	denotes	branch
T3225	7888-7892	JJ	denotes	same
T3226	7900-7902	IN	denotes	of
T3227	7903-7906	DT	denotes	the
T3228	7925-7929	NN	denotes	tree
T3229	7907-7911	NN	denotes	TACC
T3230	7912-7924	JJ	denotes	phylogenetic
T3231	7930-7934	IN	denotes	with
T3232	7935-7938	DT	denotes	the
T3233	7951-7962	NNS	denotes	orthologues
T3234	7939-7944	JJ	denotes	other
T3235	7945-7950	NN	denotes	TACC3
T3236	7962-7964	,	denotes	,
T3237	7964-7973	VBG	denotes	including
T3238	7974-7980	NN	denotes	maskin
T3239	7981-7982	-LRB-	denotes	(
T3240	7982-7989	NNP	denotes	Xenopus
T3241	7990-7996	NNP	denotes	laevis
T3242	7996-7997	-RRB-	denotes	)
T3243	7997-7999	,	denotes	,
T3244	7999-8002	CC	denotes	and
T3245	8003-8006	DT	denotes	the
T3246	8030-8039	NNS	denotes	sequences
T3247	8007-8012	RB	denotes	newly
T3248	8013-8023	VBN	denotes	identified
T3249	8024-8029	NN	denotes	TACC3
T3250	8040-8042	IN	denotes	in
T3251	8043-8049	NNP	denotes	Rattus
T3252	8050-8058	NNP	denotes	norvegus
T3253	8058-8060	,	denotes	,
T3254	8060-8066	NNP	denotes	Gallus
T3255	8067-8073	NN	denotes	gallus
T3256	8073-8075	,	denotes	,
T3257	8075-8083	NNP	denotes	Silurana
T3258	8084-8094	NNP	denotes	tropicalis
T3259	8094-8096	,	denotes	,
T3260	8096-8101	NNP	denotes	Danio
T3261	8102-8107	NNP	denotes	rerio
T3262	8108-8111	CC	denotes	and
T3263	8112-8114	NNP	denotes	T.
T3264	8115-8123	NNP	denotes	rubripes
T3265	8123-8125	,	denotes	,
T3266	8125-8133	VBN	denotes	reported
T3267	8134-8136	IN	denotes	in
T3268	8137-8141	DT	denotes	this
T3269	8142-8152	NN	denotes	manuscript
T3270	8153-8154	-LRB-	denotes	(
T3271	8154-8158	NN	denotes	Fig.
T3272	8159-8160	CD	denotes	1
T3273	8160-8161	-RRB-	denotes	)
T3274	8161-8162	.	denotes	.
T3275	8162-8271	sentence	denotes	Thus, it is not in a separate branch that may be expected if the sequence was a distinct TACC family member.
T3276	8163-8167	RB	denotes	Thus
T3277	8172-8174	VBZ	denotes	is
T3278	8167-8169	,	denotes	,
T3279	8169-8171	PRP	denotes	it
T3280	8175-8178	RB	denotes	not
T3281	8179-8181	IN	denotes	in
T3282	8182-8183	DT	denotes	a
T3283	8193-8199	NN	denotes	branch
T3284	8184-8192	JJ	denotes	separate
T3285	8200-8204	WDT	denotes	that
T3286	8212-8220	VBN	denotes	expected
T3287	8205-8208	MD	denotes	may
T3288	8209-8211	VB	denotes	be
T3289	8221-8223	IN	denotes	if
T3290	8237-8240	VBD	denotes	was
T3291	8224-8227	DT	denotes	the
T3292	8228-8236	NN	denotes	sequence
T3293	8241-8242	DT	denotes	a
T3294	8264-8270	NN	denotes	member
T3295	8243-8251	JJ	denotes	distinct
T3296	8252-8256	NN	denotes	TACC
T3297	8257-8263	NN	denotes	family
T3298	8270-8271	.	denotes	.
T3412	8273-8282	NN	denotes	Placement
T3413	8283-8285	IN	denotes	of
T3414	8286-8289	DT	denotes	the
T3415	8296-8300	NN	denotes	gene
T3416	8290-8295	NN	denotes	RHAMM
T3417	8301-8303	IN	denotes	in
T3418	8304-8307	DT	denotes	the
T3419	8308-8317	NN	denotes	phylogeny
T3420	8318-8320	IN	denotes	of
T3421	8321-8324	DT	denotes	the
T3422	8342-8348	NN	denotes	family
T3423	8325-8331	VBN	denotes	coiled
T3424	8332-8336	NN	denotes	coil
T3425	8337-8341	NN	denotes	gene
T3426	8348-8440	sentence	denotes	Human RHAMM has also been proposed to be the missing fourth member of the TACC family [10].
T3427	8349-8354	JJ	denotes	Human
T3428	8355-8360	NN	denotes	RHAMM
T3429	8375-8383	VBN	denotes	proposed
T3430	8361-8364	VBZ	denotes	has
T3431	8365-8369	RB	denotes	also
T3432	8370-8374	VBN	denotes	been
T3433	8384-8386	TO	denotes	to
T3434	8387-8389	VB	denotes	be
T3435	8390-8393	DT	denotes	the
T3436	8409-8415	NN	denotes	member
T3437	8394-8401	VBG	denotes	missing
T3438	8402-8408	JJ	denotes	fourth
T3439	8416-8418	IN	denotes	of
T3440	8419-8422	DT	denotes	the
T3441	8428-8434	NN	denotes	family
T3442	8423-8427	NN	denotes	TACC
T3443	8435-8436	-LRB-	denotes	[
T3444	8436-8438	CD	denotes	10
T3445	8438-8439	-RRB-	denotes	]
T3446	8439-8440	.	denotes	.
T3447	8440-8692	sentence	denotes	Evidence used in support of this claim included its chromosomal location on 5q32 in humans (discussed below), its sequence similarity in its coiled coil domain to the TACC domain and the subcellular localization of the RHAMM protein in the centrosome.
T3448	8441-8449	NN	denotes	Evidence
T3449	8480-8488	VBD	denotes	included
T3450	8450-8454	VBN	denotes	used
T3451	8455-8457	IN	denotes	in
T3452	8458-8465	NN	denotes	support
T3453	8466-8468	IN	denotes	of
T3454	8469-8473	DT	denotes	this
T3455	8474-8479	NN	denotes	claim
T3456	8489-8492	PRP$	denotes	its
T3457	8505-8513	NN	denotes	location
T3458	8493-8504	JJ	denotes	chromosomal
T3459	8514-8516	IN	denotes	on
T3460	8517-8521	NN	denotes	5q32
T3461	8522-8524	IN	denotes	in
T3462	8525-8531	NNS	denotes	humans
T3463	8532-8533	-LRB-	denotes	(
T3464	8533-8542	VBN	denotes	discussed
T3465	8543-8548	RB	denotes	below
T3466	8548-8549	-RRB-	denotes	)
T3467	8549-8551	,	denotes	,
T3468	8551-8554	PRP$	denotes	its
T3469	8564-8574	NN	denotes	similarity
T3470	8555-8563	NN	denotes	sequence
T3471	8575-8577	IN	denotes	in
T3472	8578-8581	PRP$	denotes	its
T3473	8594-8600	NN	denotes	domain
T3474	8582-8588	VBN	denotes	coiled
T3475	8589-8593	NN	denotes	coil
T3476	8601-8603	IN	denotes	to
T3477	8604-8607	DT	denotes	the
T3478	8613-8619	NN	denotes	domain
T3479	8608-8612	NN	denotes	TACC
T3480	8620-8623	CC	denotes	and
T3481	8624-8627	DT	denotes	the
T3482	8640-8652	NN	denotes	localization
T3483	8628-8639	JJ	denotes	subcellular
T3484	8653-8655	IN	denotes	of
T3485	8656-8659	DT	denotes	the
T3486	8666-8673	NN	denotes	protein
T3487	8660-8665	NN	denotes	RHAMM
T3488	8674-8676	IN	denotes	in
T3489	8677-8680	DT	denotes	the
T3490	8681-8691	NN	denotes	centrosome
T3491	8691-8692	.	denotes	.
T3492	8692-8901	sentence	denotes	However, if RHAMM were a bona fide TACC family member, then we would predict its evolution would be similar to those of other TACC family members, and fit with the proposed evolution of the vertebrate genome.
T3493	8693-8700	RB	denotes	However
T3494	8762-8769	VB	denotes	predict
T3495	8700-8702	,	denotes	,
T3496	8702-8704	IN	denotes	if
T3497	8711-8715	VB	denotes	were
T3498	8705-8710	NN	denotes	RHAMM
T3499	8716-8717	DT	denotes	a
T3500	8740-8746	NN	denotes	member
T3501	8718-8722	FW	denotes	bona
T3502	8723-8727	FW	denotes	fide
T3503	8728-8732	NN	denotes	TACC
T3504	8733-8739	NN	denotes	family
T3505	8746-8748	,	denotes	,
T3506	8748-8752	RB	denotes	then
T3507	8753-8755	PRP	denotes	we
T3508	8756-8761	MD	denotes	would
T3509	8770-8773	PRP$	denotes	its
T3510	8774-8783	NN	denotes	evolution
T3511	8790-8792	VB	denotes	be
T3512	8784-8789	MD	denotes	would
T3513	8793-8800	JJ	denotes	similar
T3514	8801-8803	IN	denotes	to
T3515	8804-8809	DT	denotes	those
T3516	8810-8812	IN	denotes	of
T3517	8813-8818	JJ	denotes	other
T3518	8831-8838	NNS	denotes	members
T3519	8819-8823	NN	denotes	TACC
T3520	8824-8830	NN	denotes	family
T3521	8838-8840	,	denotes	,
T3522	8840-8843	CC	denotes	and
T3523	8844-8847	VB	denotes	fit
T3524	8848-8852	IN	denotes	with
T3525	8853-8856	DT	denotes	the
T3526	8866-8875	NN	denotes	evolution
T3527	8857-8865	VBN	denotes	proposed
T3528	8876-8878	IN	denotes	of
T3529	8879-8882	DT	denotes	the
T3530	8894-8900	NN	denotes	genome
T3531	8883-8893	NN	denotes	vertebrate
T3532	8900-8901	.	denotes	.
T3533	8901-9066	sentence	denotes	Thus, we set out to identify RHAMM orthologues and related genes in metazoans, so that a more complete phylogeny of the coiled coil super family could be generated.
T3534	8902-8906	RB	denotes	Thus
T3535	8911-8914	VBD	denotes	set
T3536	8906-8908	,	denotes	,
T3537	8908-8910	PRP	denotes	we
T3538	8915-8918	RP	denotes	out
T3539	8919-8921	TO	denotes	to
T3540	8922-8930	VB	denotes	identify
T3541	8931-8936	NN	denotes	RHAMM
T3542	8937-8948	NNS	denotes	orthologues
T3543	8949-8952	CC	denotes	and
T3544	8953-8960	VBN	denotes	related
T3545	8961-8966	NNS	denotes	genes
T3546	8967-8969	IN	denotes	in
T3547	8970-8979	NNS	denotes	metazoans
T3548	8979-8981	,	denotes	,
T3549	8981-8983	IN	denotes	so
T3550	9056-9065	VBN	denotes	generated
T3551	8984-8988	IN	denotes	that
T3552	8989-8990	DT	denotes	a
T3553	9005-9014	NN	denotes	phylogeny
T3554	8991-8995	RBR	denotes	more
T3555	8996-9004	JJ	denotes	complete
T3556	9015-9017	IN	denotes	of
T3557	9018-9021	DT	denotes	the
T3558	9040-9046	NN	denotes	family
T3559	9022-9028	VBN	denotes	coiled
T3560	9029-9033	NN	denotes	coil
T3561	9034-9039	JJ	denotes	super
T3562	9047-9052	MD	denotes	could
T3563	9053-9055	VB	denotes	be
T3564	9065-9066	.	denotes	.
T3565	9066-9202	sentence	denotes	We identified a single RHAMM gene in all deuterostomes for which cDNA and/or genomic sequence was available, including C. intestinalis.
T3566	9067-9069	PRP	denotes	We
T3567	9070-9080	VBD	denotes	identified
T3568	9081-9082	DT	denotes	a
T3569	9096-9100	NN	denotes	gene
T3570	9083-9089	JJ	denotes	single
T3571	9090-9095	NN	denotes	RHAMM
T3572	9101-9103	IN	denotes	in
T3573	9104-9107	DT	denotes	all
T3574	9108-9121	NNS	denotes	deuterostomes
T3575	9122-9125	IN	denotes	for
T3576	9161-9164	VBD	denotes	was
T3577	9126-9131	WDT	denotes	which
T3578	9132-9136	NN	denotes	cDNA
T3579	9152-9160	NN	denotes	sequence
T3580	9137-9140	CC	denotes	and
T3581	9140-9141	HYPH	denotes	/
T3582	9141-9143	CC	denotes	or
T3583	9144-9151	JJ	denotes	genomic
T3584	9165-9174	JJ	denotes	available
T3585	9174-9176	,	denotes	,
T3586	9176-9185	VBG	denotes	including
T3587	9186-9188	NNP	denotes	C.
T3588	9189-9201	NNP	denotes	intestinalis
T3589	9201-9202	.	denotes	.
T3590	9202-9256	sentence	denotes	No RHAMM gene was identified in insects or nematodes.
T3591	9203-9205	DT	denotes	No
T3592	9212-9216	NN	denotes	gene
T3593	9206-9211	NN	denotes	RHAMM
T3594	9221-9231	VBN	denotes	identified
T3595	9217-9220	VBD	denotes	was
T3596	9232-9234	IN	denotes	in
T3597	9235-9242	NNS	denotes	insects
T3598	9243-9245	CC	denotes	or
T3599	9246-9255	NNS	denotes	nematodes
T3600	9255-9256	.	denotes	.
T3601	9256-9425	sentence	denotes	This indicates that the RHAMM/TACC genes diverged after the protostome/deuterostome split 833–933 MYA, but prior to the echinodermata/urochordate divergence (>750 MYA).
T3602	9257-9261	DT	denotes	This
T3603	9262-9271	VBZ	denotes	indicates
T3604	9272-9276	IN	denotes	that
T3605	9298-9306	VBD	denotes	diverged
T3606	9277-9280	DT	denotes	the
T3607	9292-9297	NNS	denotes	genes
T3608	9281-9286	NN	denotes	RHAMM
T3609	9287-9291	NN	denotes	TACC
T3610	9286-9287	HYPH	denotes	/
T3611	9307-9312	IN	denotes	after
T3612	9341-9346	VBD	denotes	split
T3613	9313-9316	DT	denotes	the
T3614	9328-9340	NN	denotes	deuterostome
T3615	9317-9327	NN	denotes	protostome
T3616	9327-9328	HYPH	denotes	/
T3617	9347-9350	CD	denotes	833
T3618	9351-9354	CD	denotes	933
T3619	9350-9351	SYM	denotes	–
T3620	9355-9358	RB	denotes	MYA
T3621	9358-9360	,	denotes	,
T3622	9360-9363	CC	denotes	but
T3623	9364-9369	RB	denotes	prior
T3624	9370-9372	IN	denotes	to
T3625	9373-9376	DT	denotes	the
T3626	9403-9413	NN	denotes	divergence
T3627	9377-9390	NN	denotes	echinodermata
T3628	9391-9402	NN	denotes	urochordate
T3629	9390-9391	HYPH	denotes	/
T3630	9414-9415	-LRB-	denotes	(
T3631	9420-9423	RB	denotes	MYA
T3632	9415-9416	SYM	denotes	>
T3633	9416-9419	CD	denotes	750
T3634	9423-9424	-RRB-	denotes	)
T3635	9424-9425	.	denotes	.
T3636	9425-9703	sentence	denotes	Significantly, sequence and phylogenetic analysis of coiled coil proteins (Fig. 1) clearly shows that RHAMM does not contain a TACC domain and instead forms a distinct family of proteins in the coiled coil superfamily, and is not a direct descendant of the ancestral TACC gene.
T3637	9426-9439	RB	denotes	Significantly
T3638	9517-9522	VBZ	denotes	shows
T3639	9439-9441	,	denotes	,
T3640	9441-9449	NN	denotes	sequence
T3641	9467-9475	NN	denotes	analysis
T3642	9450-9453	CC	denotes	and
T3643	9454-9466	JJ	denotes	phylogenetic
T3644	9476-9478	IN	denotes	of
T3645	9479-9485	VBN	denotes	coiled
T3646	9486-9490	NN	denotes	coil
T3647	9491-9499	NN	denotes	proteins
T3648	9500-9501	-LRB-	denotes	(
T3649	9501-9505	NN	denotes	Fig.
T3650	9506-9507	CD	denotes	1
T3651	9507-9508	-RRB-	denotes	)
T3652	9509-9516	RB	denotes	clearly
T3653	9523-9527	IN	denotes	that
T3654	9543-9550	VB	denotes	contain
T3655	9528-9533	NN	denotes	RHAMM
T3656	9534-9538	VBZ	denotes	does
T3657	9539-9542	RB	denotes	not
T3658	9551-9552	DT	denotes	a
T3659	9558-9564	NN	denotes	domain
T3660	9553-9557	NN	denotes	TACC
T3661	9565-9568	CC	denotes	and
T3662	9569-9576	RB	denotes	instead
T3663	9577-9582	VBZ	denotes	forms
T3664	9583-9584	DT	denotes	a
T3665	9594-9600	NN	denotes	family
T3666	9585-9593	JJ	denotes	distinct
T3667	9601-9603	IN	denotes	of
T3668	9604-9612	NN	denotes	proteins
T3669	9613-9615	IN	denotes	in
T3670	9616-9619	DT	denotes	the
T3671	9632-9643	NN	denotes	superfamily
T3672	9620-9626	VBN	denotes	coiled
T3673	9627-9631	NN	denotes	coil
T3674	9643-9645	,	denotes	,
T3675	9645-9648	CC	denotes	and
T3676	9649-9651	VBZ	denotes	is
T3677	9652-9655	RB	denotes	not
T3678	9656-9657	DT	denotes	a
T3679	9665-9675	NN	denotes	descendant
T3680	9658-9664	JJ	denotes	direct
T3681	9676-9678	IN	denotes	of
T3682	9679-9682	DT	denotes	the
T3683	9698-9702	NN	denotes	gene
T3684	9683-9692	JJ	denotes	ancestral
T3685	9693-9697	NN	denotes	TACC
T3686	9702-9703	.	denotes	.
T4145	9705-9714	NN	denotes	Evolution
T4146	9715-9717	IN	denotes	of
T4147	9718-9721	DT	denotes	the
T4148	9734-9742	NNS	denotes	segments
T4149	9722-9733	JJ	denotes	chromosomal
T4150	9743-9753	VBG	denotes	containing
T4151	9754-9757	DT	denotes	the
T4152	9763-9768	NNS	denotes	genes
T4153	9758-9762	NN	denotes	TACC
T4154	9768-9864	sentence	denotes	The phylogenetic tree of the FGFR genes closely resembles that of the vertebrate TACC1-3 genes.
T4155	9769-9772	DT	denotes	The
T4156	9786-9790	NN	denotes	tree
T4157	9773-9785	JJ	denotes	phylogenetic
T4158	9817-9826	VBZ	denotes	resembles
T4159	9791-9793	IN	denotes	of
T4160	9794-9797	DT	denotes	the
T4161	9803-9808	NNS	denotes	genes
T4162	9798-9802	NN	denotes	FGFR
T4163	9809-9816	RB	denotes	closely
T4164	9827-9831	DT	denotes	that
T4165	9832-9834	IN	denotes	of
T4166	9835-9838	DT	denotes	the
T4167	9858-9863	NNS	denotes	genes
T4168	9839-9849	NN	denotes	vertebrate
T4169	9850-9855	NN	denotes	TACC1
T4170	9855-9856	HYPH	denotes	-
T4171	9856-9857	CD	denotes	3
T4172	9863-9864	.	denotes	.
T4173	9864-10140	sentence	denotes	Recently, detailed analyses of the chromosomal regions containing the FGFR gene family in humans, mouse and the arthopod D. melanogaster have revealed the conservation of paralogous chromosomal segments between these organisms (Fig. 2, [13], Table 1 [see Additional file 1]).
T4174	9865-9873	RB	denotes	Recently
T4175	10007-10015	VBN	denotes	revealed
T4176	9873-9875	,	denotes	,
T4177	9875-9883	JJ	denotes	detailed
T4178	9884-9892	NNS	denotes	analyses
T4179	9893-9895	IN	denotes	of
T4180	9896-9899	DT	denotes	the
T4181	9912-9919	NNS	denotes	regions
T4182	9900-9911	JJ	denotes	chromosomal
T4183	9920-9930	VBG	denotes	containing
T4184	9931-9934	DT	denotes	the
T4185	9945-9951	NN	denotes	family
T4186	9935-9939	NN	denotes	FGFR
T4187	9940-9944	NN	denotes	gene
T4188	9952-9954	IN	denotes	in
T4189	9955-9961	NNS	denotes	humans
T4190	9961-9963	,	denotes	,
T4191	9963-9968	NN	denotes	mouse
T4192	9969-9972	CC	denotes	and
T4193	9973-9976	DT	denotes	the
T4194	9977-9985	NN	denotes	arthopod
T4195	9986-9988	NNP	denotes	D.
T4196	9989-10001	NNP	denotes	melanogaster
T4197	10002-10006	VBP	denotes	have
T4198	10016-10019	DT	denotes	the
T4199	10020-10032	NN	denotes	conservation
T4200	10033-10035	IN	denotes	of
T4201	10036-10046	JJ	denotes	paralogous
T4202	10059-10067	NNS	denotes	segments
T4203	10047-10058	JJ	denotes	chromosomal
T4204	10068-10075	IN	denotes	between
T4205	10076-10081	DT	denotes	these
T4206	10082-10091	NNS	denotes	organisms
T4207	10092-10093	-LRB-	denotes	(
T4208	10107-10112	NN	denotes	Table
T4209	10093-10097	NN	denotes	Fig.
T4210	10098-10099	CD	denotes	2
T4211	10099-10101	,	denotes	,
T4212	10101-10102	-LRB-	denotes	[
T4213	10102-10104	CD	denotes	13
T4214	10104-10105	-RRB-	denotes	]
T4215	10105-10107	,	denotes	,
T4216	10113-10114	CD	denotes	1
T4217	10115-10116	-LRB-	denotes	[
T4218	10116-10119	VB	denotes	see
T4219	10120-10130	JJ	denotes	Additional
T4220	10131-10135	NN	denotes	file
T4221	10136-10137	CD	denotes	1
T4222	10137-10138	-RRB-	denotes	]
T4223	10138-10139	-RRB-	denotes	)
T4224	10139-10140	.	denotes	.
T4225	10140-10449	sentence	denotes	This has provided further support that an ancient chromosomal segment was duplicated twice during vertebrate evolution, with the first duplication that gave rise to the human chromosome 4p16/5q32-ter and human chromosome 8p/10q23-ter ancestors occurring in the early stages after the invertebrate divergence.
T4226	10141-10145	DT	denotes	This
T4227	10150-10158	VBN	denotes	provided
T4228	10146-10149	VBZ	denotes	has
T4229	10159-10166	JJ	denotes	further
T4230	10167-10174	NN	denotes	support
T4231	10175-10179	IN	denotes	that
T4232	10215-10225	VBN	denotes	duplicated
T4233	10180-10182	DT	denotes	an
T4234	10203-10210	NN	denotes	segment
T4235	10183-10190	JJ	denotes	ancient
T4236	10191-10202	JJ	denotes	chromosomal
T4237	10211-10214	VBD	denotes	was
T4238	10226-10231	RB	denotes	twice
T4239	10232-10238	IN	denotes	during
T4240	10239-10249	NN	denotes	vertebrate
T4241	10250-10259	NN	denotes	evolution
T4242	10259-10261	,	denotes	,
T4243	10261-10265	IN	denotes	with
T4244	10266-10269	DT	denotes	the
T4245	10276-10287	NN	denotes	duplication
T4246	10270-10275	JJ	denotes	first
T4247	10385-10394	VBG	denotes	occurring
T4248	10288-10292	WDT	denotes	that
T4249	10293-10297	VBD	denotes	gave
T4250	10298-10302	NN	denotes	rise
T4251	10303-10305	IN	denotes	to
T4252	10306-10309	DT	denotes	the
T4253	10375-10384	NNS	denotes	ancestors
T4254	10310-10315	JJ	denotes	human
T4255	10316-10326	NN	denotes	chromosome
T4256	10337-10340	NN	denotes	ter
T4257	10327-10331	NN	denotes	4p16
T4258	10332-10336	NN	denotes	5q32
T4259	10331-10332	HYPH	denotes	/
T4260	10336-10337	HYPH	denotes	-
T4261	10341-10344	CC	denotes	and
T4262	10345-10350	JJ	denotes	human
T4263	10351-10361	NN	denotes	chromosome
T4264	10371-10374	NN	denotes	ter
T4265	10362-10364	NN	denotes	8p
T4266	10365-10370	NN	denotes	10q23
T4267	10364-10365	HYPH	denotes	/
T4268	10370-10371	HYPH	denotes	-
T4269	10395-10397	IN	denotes	in
T4270	10398-10401	DT	denotes	the
T4271	10408-10414	NNS	denotes	stages
T4272	10402-10407	JJ	denotes	early
T4273	10415-10420	IN	denotes	after
T4274	10421-10424	DT	denotes	the
T4275	10438-10448	NN	denotes	divergence
T4276	10425-10437	NN	denotes	invertebrate
T4277	10448-10449	.	denotes	.
T4278	10449-10667	sentence	denotes	This suggests that the ancestral FGFR-TACC gene pair most probably arose prior to the initial duplication and subsequent divergence of these paralogous chromosomal segments, estimated to have occurred 687 ± 155.7 MYA.
T4279	10450-10454	DT	denotes	This
T4280	10455-10463	VBZ	denotes	suggests
T4281	10464-10468	IN	denotes	that
T4282	10517-10522	VBD	denotes	arose
T4283	10469-10472	DT	denotes	the
T4284	10498-10502	NN	denotes	pair
T4285	10473-10482	JJ	denotes	ancestral
T4286	10483-10487	NN	denotes	FGFR
T4287	10488-10492	NN	denotes	TACC
T4288	10487-10488	HYPH	denotes	-
T4289	10493-10497	NN	denotes	gene
T4290	10503-10507	RBS	denotes	most
T4291	10508-10516	RB	denotes	probably
T4292	10523-10528	JJ	denotes	prior
T4293	10529-10531	IN	denotes	to
T4294	10532-10535	DT	denotes	the
T4295	10544-10555	NN	denotes	duplication
T4296	10536-10543	JJ	denotes	initial
T4297	10556-10559	CC	denotes	and
T4298	10560-10570	JJ	denotes	subsequent
T4299	10571-10581	NN	denotes	divergence
T4300	10582-10584	IN	denotes	of
T4301	10585-10590	DT	denotes	these
T4302	10614-10622	NNS	denotes	segments
T4303	10591-10601	JJ	denotes	paralogous
T4304	10602-10613	JJ	denotes	chromosomal
T4305	10622-10624	,	denotes	,
T4306	10624-10633	VBN	denotes	estimated
T4307	10634-10636	TO	denotes	to
T4308	10642-10650	VBN	denotes	occurred
T4309	10637-10641	VB	denotes	have
T4310	10651-10654	CD	denotes	687
T4311	10657-10662	CD	denotes	155.7
T4312	10655-10656	SYM	denotes	±
T4313	10663-10666	RB	denotes	MYA
T4314	10666-10667	.	denotes	.
T4315	10667-10791	sentence	denotes	This has raised the suggestion that a fourth TACC gene in vertebrates would reside in the same chromosomal region as FGFR4.
T4316	10668-10672	DT	denotes	This
T4317	10677-10683	VBN	denotes	raised
T4318	10673-10676	VBZ	denotes	has
T4319	10684-10687	DT	denotes	the
T4320	10688-10698	NN	denotes	suggestion
T4321	10699-10703	IN	denotes	that
T4322	10744-10750	VB	denotes	reside
T4323	10704-10705	DT	denotes	a
T4324	10718-10722	NN	denotes	gene
T4325	10706-10712	JJ	denotes	fourth
T4326	10713-10717	NN	denotes	TACC
T4327	10723-10725	IN	denotes	in
T4328	10726-10737	NNS	denotes	vertebrates
T4329	10738-10743	MD	denotes	would
T4330	10751-10753	IN	denotes	in
T4331	10754-10757	DT	denotes	the
T4332	10775-10781	NN	denotes	region
T4333	10758-10762	JJ	denotes	same
T4334	10763-10774	JJ	denotes	chromosomal
T4335	10782-10784	IN	denotes	as
T4336	10785-10790	NN	denotes	FGFR4
T4337	10790-10791	.	denotes	.
T4338	10791-10895	sentence	denotes	Indeed this hypothesis has been used in support for the RHAMM gene as a member of the TACC family [10].
T4339	10792-10798	RB	denotes	Indeed
T4340	10824-10828	VBN	denotes	used
T4341	10799-10803	DT	denotes	this
T4342	10804-10814	NN	denotes	hypothesis
T4343	10815-10818	VBZ	denotes	has
T4344	10819-10823	VBN	denotes	been
T4345	10829-10831	IN	denotes	in
T4346	10832-10839	NN	denotes	support
T4347	10840-10843	IN	denotes	for
T4348	10844-10847	DT	denotes	the
T4349	10854-10858	NN	denotes	gene
T4350	10848-10853	NN	denotes	RHAMM
T4351	10859-10861	IN	denotes	as
T4352	10862-10863	DT	denotes	a
T4353	10864-10870	NN	denotes	member
T4354	10871-10873	IN	denotes	of
T4355	10874-10877	DT	denotes	the
T4356	10883-10889	NN	denotes	family
T4357	10878-10882	NN	denotes	TACC
T4358	10890-10891	-LRB-	denotes	[
T4359	10891-10893	CD	denotes	10
T4360	10893-10894	-RRB-	denotes	]
T4361	10894-10895	.	denotes	.
T4362	10895-10970	sentence	denotes	Human RHAMM maps to chromosome 5q32 in a region bounded by GPX3 and NKX2E.
T4363	10896-10901	JJ	denotes	Human
T4364	10902-10907	NN	denotes	RHAMM
T4365	10908-10912	VBZ	denotes	maps
T4366	10913-10915	IN	denotes	to
T4367	10916-10926	NN	denotes	chromosome
T4368	10927-10931	NN	denotes	5q32
T4369	10932-10934	IN	denotes	in
T4370	10935-10936	DT	denotes	a
T4371	10937-10943	NN	denotes	region
T4372	10944-10951	VBN	denotes	bounded
T4373	10952-10954	IN	denotes	by
T4374	10955-10959	NN	denotes	GPX3
T4375	10960-10963	CC	denotes	and
T4376	10964-10969	NN	denotes	NKX2E
T4377	10969-10970	.	denotes	.
T4378	10970-11065	sentence	denotes	These loci separate two clusters of genes on human chromosome 5 that are paralogous with 4p16.
T4379	10971-10976	DT	denotes	These
T4380	10977-10981	NNS	denotes	loci
T4381	10982-10990	VBP	denotes	separate
T4382	10991-10994	CD	denotes	two
T4383	10995-11003	NNS	denotes	clusters
T4384	11004-11006	IN	denotes	of
T4385	11007-11012	NNS	denotes	genes
T4386	11013-11015	IN	denotes	on
T4387	11016-11021	JJ	denotes	human
T4388	11022-11032	NN	denotes	chromosome
T4389	11033-11034	CD	denotes	5
T4390	11035-11039	WDT	denotes	that
T4391	11040-11043	VBP	denotes	are
T4392	11044-11054	JJ	denotes	paralogous
T4393	11055-11059	IN	denotes	with
T4394	11060-11064	CD	denotes	4p16
T4395	11064-11065	.	denotes	.
T4396	11065-11280	sentence	denotes	Interestingly, these three clusters are located on different chromosomes in mouse and rat (Fig. 2), further suggesting that this cluster of genes was transposed into this region after the primate/rodent divergence.
T4397	11066-11079	RB	denotes	Interestingly
T4398	11106-11113	VBN	denotes	located
T4399	11079-11081	,	denotes	,
T4400	11081-11086	DT	denotes	these
T4482	12194-12195	``	denotes	"
T4483	12204-12205	''	denotes	"
T4484	12206-12213	JJ	denotes	compact
T4485	12214-12224	NN	denotes	vertebrate
T4486	12232-12241	VBN	denotes	sequenced
T4487	12242-12244	IN	denotes	to
T4488	12245-12249	NN	denotes	date
T4489	12249-12251	,	denotes	,
T4490	12251-12253	NNP	denotes	T.
T4491	12254-12262	NNP	denotes	rubripes
T4492	12263-12264	-LRB-	denotes	[
T4493	12264-12266	CD	denotes	14
T4494	12266-12267	-RRB-	denotes	]
T4495	12267-12268	.	denotes	.
T4496	12268-12444	sentence	denotes	Although not fully assembled, examination of the genome of T. rubripes confirmed the presence of chromosomal segments paralogous to those found in higher vertebrates (Fig. 2).
T4497	12269-12277	IN	denotes	Although
T4498	12288-12297	VBN	denotes	assembled
T4499	12278-12281	RB	denotes	not
T4500	12282-12287	RB	denotes	fully
T4501	12340-12349	VBD	denotes	confirmed
T4502	12297-12299	,	denotes	,
T4503	12299-12310	NN	denotes	examination
T4504	12311-12313	IN	denotes	of
T4505	12314-12317	DT	denotes	the
T4506	12318-12324	NN	denotes	genome
T4507	12325-12327	IN	denotes	of
T4508	12328-12330	NNP	denotes	T.
T4509	12331-12339	NNP	denotes	rubripes
T4510	12350-12353	DT	denotes	the
T4511	12354-12362	NN	denotes	presence
T4512	12363-12365	IN	denotes	of
T4513	12366-12377	JJ	denotes	chromosomal
T4514	12378-12386	NNS	denotes	segments
T4515	12387-12397	JJ	denotes	paralogous
T4516	12398-12400	IN	denotes	to
T4517	12401-12406	DT	denotes	those
T4518	12407-12412	VBN	denotes	found
T4519	12413-12415	IN	denotes	in
T4520	12416-12422	JJR	denotes	higher
T4521	12423-12434	NNS	denotes	vertebrates
T4522	12435-12436	-LRB-	denotes	(
T4523	12436-12440	NN	denotes	Fig.
T4524	12441-12442	CD	denotes	2
T4525	12442-12443	-RRB-	denotes	)
T4526	12443-12444	.	denotes	.
T4527	12444-12601	sentence	denotes	For instance, the orthologues of GPRK2L and RGS12 are found on T. rubripes scaffold 290 (emb\|CAAB01000290.1), and within 300 kb of each other in human 4p16.
T4528	12445-12448	IN	denotes	For
T4529	12499-12504	VBN	denotes	found
T4530	12449-12457	NN	denotes	instance
T4531	12457-12459	,	denotes	,
T4532	12459-12462	DT	denotes	the
T4533	12463-12474	NNS	denotes	orthologues
T4534	12475-12477	IN	denotes	of
T4535	12478-12484	NN	denotes	GPRK2L
T4536	12485-12488	CC	denotes	and
T4537	12489-12494	NN	denotes	RGS12
T4538	12495-12498	VBP	denotes	are
T4539	12505-12507	IN	denotes	on
T4540	12508-12510	NNP	denotes	T.
T4541	12511-12519	NNP	denotes	rubripes
T4542	12520-12528	NN	denotes	scaffold
T4543	12529-12532	CD	denotes	290
T4544	12533-12534	-LRB-	denotes	(
T4545	12534-12552	NN	denotes	emb\|CAAB01000290.1
T4546	12552-12553	-RRB-	denotes	)
T4547	12553-12555	,	denotes	,
T4548	12555-12558	CC	denotes	and
T4549	12559-12565	IN	denotes	within
T4550	12566-12569	CD	denotes	300
T4551	12570-12572	NN	denotes	kb
T4552	12573-12575	IN	denotes	of
T4553	12576-12580	DT	denotes	each
T4554	12581-12586	JJ	denotes	other
T4555	12587-12589	IN	denotes	in
T4556	12590-12595	JJ	denotes	human
T4557	12596-12600	CD	denotes	4p16
T4558	12600-12601	.	denotes	.
T4559	12601-12729	sentence	denotes	The T. rubripes orthologues of FGFR3, LETM1 and WHSC1 are located on the same 166 kb genomic scaffold 251 (emb\|CAAB01000166.1).
T4560	12602-12605	DT	denotes	The
T4561	12618-12629	NNS	denotes	orthologues
T4562	12606-12608	NNP	denotes	T.
T4563	12609-12617	NNP	denotes	rubripes
T4564	12660-12667	VBN	denotes	located
T4565	12630-12632	IN	denotes	of
T4566	12633-12638	NN	denotes	FGFR3
T4567	12638-12640	,	denotes	,
T4568	12640-12645	NN	denotes	LETM1
T4569	12646-12649	CC	denotes	and
T4570	12650-12655	NN	denotes	WHSC1
T4571	12656-12659	VBP	denotes	are
T4572	12668-12670	IN	denotes	on
T4573	12671-12674	DT	denotes	the
T4574	12695-12703	NN	denotes	scaffold
T4575	12675-12679	JJ	denotes	same
T4576	12680-12683	CD	denotes	166
T4577	12684-12686	NN	denotes	kb
T4578	12687-12694	JJ	denotes	genomic
T4579	12704-12707	CD	denotes	251
T4580	12708-12709	-LRB-	denotes	(
T4581	12709-12727	NN	denotes	emb\|CAAB01000166.1
T4582	12727-12728	-RRB-	denotes	)
T4583	12728-12729	.	denotes	.
T4584	12729-12841	sentence	denotes	Significantly, the three human orthologues of these genes are also located within 300 kb of each other on 4p16.
T4585	12730-12743	RB	denotes	Significantly
T4586	12797-12804	VBN	denotes	located
T4587	12743-12745	,	denotes	,
T4588	12745-12748	DT	denotes	the
T4589	12761-12772	NNS	denotes	orthologues
T4590	12749-12754	CD	denotes	three
T4591	12755-12760	JJ	denotes	human
T4592	12773-12775	IN	denotes	of
T4593	12776-12781	DT	denotes	these
T4594	12782-12787	NNS	denotes	genes
T4595	12788-12791	VBP	denotes	are
T4596	12792-12796	RB	denotes	also
T4597	12805-12811	IN	denotes	within
T4598	12812-12815	CD	denotes	300
T4599	12816-12818	NN	denotes	kb
T4600	12819-12821	IN	denotes	of
T4601	12822-12826	DT	denotes	each
T4602	12827-12832	JJ	denotes	other
T4603	12833-12835	IN	denotes	on
T4604	12836-12840	NN	denotes	4p16
T4605	12840-12841	.	denotes	.
T4606	12841-12933	sentence	denotes	Furthermore, TACC3 and FGFRL map to the overlapping scaffolds 1184/4669 (emb\|CAAB01004668).
T4607	12842-12853	RB	denotes	Furthermore
T4608	12871-12874	VBP	denotes	map
T4609	12853-12855	,	denotes	,
T4610	12855-12860	NN	denotes	TACC3
T4611	12861-12864	CC	denotes	and
T4612	12865-12870	NN	denotes	FGFRL
T4613	12875-12877	IN	denotes	to
T4614	12878-12881	DT	denotes	the
T4615	12894-12903	NNS	denotes	scaffolds
T4616	12882-12893	VBG	denotes	overlapping
T4617	12904-12908	CD	denotes	1184
T4618	12909-12913	CD	denotes	4669
T4619	12908-12909	HYPH	denotes	/
T4620	12914-12915	-LRB-	denotes	(
T4621	12915-12931	NN	denotes	emb\|CAAB01004668
T4622	12931-12932	-RRB-	denotes	)
T4623	12932-12933	.	denotes	.
T4624	12933-13182	sentence	denotes	Similarly, elements of these gene clusters, extending from HMP19 to GPRK6 in human chromosome 5q34-ter are also found in the pufferfish, with the T. rubripes orthologues of NSD1, FGFR4 and a RAB-like gene mapping on scaffold 407 (emb\|CAAB01000407).
T4625	12934-12943	RB	denotes	Similarly
T4626	13046-13051	VBN	denotes	found
T4627	12943-12945	,	denotes	,
T4628	12945-12953	NNS	denotes	elements
T4629	12954-12956	IN	denotes	of
T4630	12957-12962	DT	denotes	these
T4631	12968-12976	NNS	denotes	clusters
T4632	12963-12967	NN	denotes	gene
T4633	12976-12978	,	denotes	,
T4634	12978-12987	VBG	denotes	extending
T4635	12988-12992	IN	denotes	from
T4636	12993-12998	NN	denotes	HMP19
T4637	12999-13001	IN	denotes	to
T4638	13002-13007	NN	denotes	GPRK6
T4639	13008-13010	IN	denotes	in
T4640	13011-13016	JJ	denotes	human
T4641	13017-13027	NN	denotes	chromosome
T4642	13033-13036	NN	denotes	ter
T4643	13028-13032	NN	denotes	5q34
T4644	13032-13033	HYPH	denotes	-
T4645	13037-13040	VBP	denotes	are
T4646	13041-13045	RB	denotes	also
T4647	13052-13054	IN	denotes	in
T4648	13055-13058	DT	denotes	the
T4649	13059-13069	NN	denotes	pufferfish
T4650	13069-13071	,	denotes	,
T4651	13071-13075	IN	denotes	with
T4652	13076-13079	DT	denotes	the
T4653	13092-13103	NNS	denotes	orthologues
T4654	13080-13082	NNP	denotes	T.
T4655	13083-13091	NNP	denotes	rubripes
T4656	13104-13106	IN	denotes	of
T4657	13107-13111	NN	denotes	NSD1
T4658	13111-13113	,	denotes	,
T4659	13113-13118	NN	denotes	FGFR4
T4660	13119-13122	CC	denotes	and
T4661	13123-13124	DT	denotes	a
T4662	13129-13133	JJ	denotes	like
T4663	13125-13128	NN	denotes	RAB
T4664	13128-13129	HYPH	denotes	-
T4665	13139-13146	NN	denotes	mapping
T4666	13134-13138	NN	denotes	gene
T4667	13147-13149	IN	denotes	on
T4668	13150-13158	NN	denotes	scaffold
T4669	13159-13162	CD	denotes	407
T4670	13163-13164	-LRB-	denotes	(
T4671	13164-13180	NN	denotes	emb\|CAAB01000407
T4672	13180-13181	-RRB-	denotes	)
T4673	13181-13182	.	denotes	.
T4674	13182-13279	sentence	denotes	However, there is no evidence for a gene corresponding to a TACC4 gene in any of these clusters.
T4675	13183-13190	RB	denotes	However
T4676	13198-13200	VBZ	denotes	is
T4677	13190-13192	,	denotes	,
T4678	13192-13197	EX	denotes	there
T4679	13201-13203	DT	denotes	no
T4680	13204-13212	NN	denotes	evidence
T4681	13213-13216	IN	denotes	for
T4682	13217-13218	DT	denotes	a
T4683	13219-13223	NN	denotes	gene
T4684	13224-13237	VBG	denotes	corresponding
T4685	13238-13240	IN	denotes	to
T4686	13241-13242	DT	denotes	a
T4687	13249-13253	NN	denotes	gene
T4688	13243-13248	NN	denotes	TACC4
T4689	13254-13256	IN	denotes	in
T4690	13257-13260	DT	denotes	any
T4691	13261-13263	IN	denotes	of
T4692	13264-13269	DT	denotes	these
T4693	13270-13278	NNS	denotes	clusters
T4694	13278-13279	.	denotes	.
T4695	13279-13406	sentence	denotes	As noted above, phylogenetic analysis of the TACC sequences indicate that there are two TACC1 related genes in the pufferfish.
T4696	13280-13282	IN	denotes	As
T4697	13283-13288	VBN	denotes	noted
T4698	13340-13348	VBP	denotes	indicate
T4699	13289-13294	RB	denotes	above
T4700	13294-13296	,	denotes	,
T4701	13296-13308	JJ	denotes	phylogenetic
T4702	13309-13317	NN	denotes	analysis
T4703	13318-13320	IN	denotes	of
T4704	13321-13324	DT	denotes	the
T4705	13330-13339	NNS	denotes	sequences
T4706	13325-13329	NN	denotes	TACC
T4707	13349-13353	IN	denotes	that
T4708	13360-13363	VBP	denotes	are
T4709	13354-13359	EX	denotes	there
T4710	13364-13367	CD	denotes	two
T4711	13382-13387	NNS	denotes	genes
T4712	13368-13373	NN	denotes	TACC1
T4713	13374-13381	VBN	denotes	related
T4714	13388-13390	IN	denotes	in
T4715	13391-13394	DT	denotes	the
T4716	13395-13405	NN	denotes	pufferfish
T4717	13405-13406	.	denotes	.
T4718	13406-13565	sentence	denotes	trTACC1B is located on the 180 kb scaffold 191 (emb\|CAAB01000191.1), which also contains the orthologues of several genes located in human chromosome 8p21-11.
T4719	13407-13415	NN	denotes	trTACC1B
T4720	13419-13426	VBN	denotes	located
T4721	13416-13418	VBZ	denotes	is
T4722	13427-13429	IN	denotes	on
T4723	13430-13433	DT	denotes	the
T4724	13441-13449	NN	denotes	scaffold
T4725	13434-13437	CD	denotes	180
T4726	13438-13440	NN	denotes	kb
T4727	13450-13453	CD	denotes	191
T4728	13454-13455	-LRB-	denotes	(
T4729	13455-13473	NN	denotes	emb\|CAAB01000191.1
T4730	13473-13474	-RRB-	denotes	)
T4731	13474-13476	,	denotes	,
T4732	13476-13481	WDT	denotes	which
T4733	13487-13495	VBZ	denotes	contains
T4734	13482-13486	RB	denotes	also
T4735	13496-13499	DT	denotes	the
T4736	13500-13511	NNS	denotes	orthologues
T4737	13512-13514	IN	denotes	of
T4738	13515-13522	JJ	denotes	several
T4739	13523-13528	NNS	denotes	genes
T4740	13529-13536	VBN	denotes	located
T4741	13537-13539	IN	denotes	in
T4742	13540-13545	JJ	denotes	human
T4743	13557-13561	NN	denotes	8p21
T4744	13546-13556	NN	denotes	chromosome
T4745	13561-13562	HYPH	denotes	-
T4746	13562-13564	CD	denotes	11
T4747	13564-13565	.	denotes	.
T4748	13565-13682	sentence	denotes	Thus, this scaffold represents the more "developed" TACC1 chromosomal segment that is evident in higher vertebrates.
T4749	13566-13570	RB	denotes	Thus
T4750	13586-13596	VBZ	denotes	represents
T4751	13570-13572	,	denotes	,
T4752	13572-13576	DT	denotes	this
T4753	13577-13585	NN	denotes	scaffold
T4754	13597-13600	DT	denotes	the
T4755	13636-13643	NN	denotes	segment
T4756	13601-13605	RBR	denotes	more
T4757	13607-13616	VBN	denotes	developed
T4758	13606-13607	``	denotes	"
T4759	13616-13617	''	denotes	"
T4760	13618-13623	NN	denotes	TACC1
T4761	13624-13635	JJ	denotes	chromosomal
T4762	13644-13648	WDT	denotes	that
T4763	13649-13651	VBZ	denotes	is
T4764	13652-13659	JJ	denotes	evident
T4765	13660-13662	IN	denotes	in
T4766	13663-13669	JJR	denotes	higher
T4767	13670-13681	NNS	denotes	vertebrates
T4768	13681-13682	.	denotes	.
T4769	13682-13776	sentence	denotes	On the other hand, the trTACC1A gene is located in the 396 kb scaffold 12 (emb\|CAAB010012.1).
T4770	13683-13685	IN	denotes	On
T4771	13723-13730	VBN	denotes	located
T4772	13686-13689	DT	denotes	the
T4773	13696-13700	NN	denotes	hand
T4774	13690-13695	JJ	denotes	other
T4775	13700-13702	,	denotes	,
T4776	13702-13705	DT	denotes	the
T4777	13715-13719	NN	denotes	gene
T4778	13706-13714	NN	denotes	trTACC1A
T4779	13720-13722	VBZ	denotes	is
T4780	13731-13733	IN	denotes	in
T4781	13734-13737	DT	denotes	the
T4782	13745-13753	NN	denotes	scaffold
T4783	13738-13741	CD	denotes	396
T4784	13742-13744	NN	denotes	kb
T4785	13754-13756	CD	denotes	12
T4786	13757-13758	-LRB-	denotes	(
T4787	13758-13774	NN	denotes	emb\|CAAB010012.1
T4788	13774-13775	-RRB-	denotes	)
T4789	13775-13776	.	denotes	.
T4790	13776-13974	sentence	denotes	This scaffold also contains the T. rubripes orthologues of MSX1, STX18, D4S234E and the predicted gene LOC118711, in addition to sequences with homology to LOXL, EVC, LOC159291, and the LDB family.
T4791	13777-13781	DT	denotes	This
T4792	13782-13790	NN	denotes	scaffold
T4793	13796-13804	VBZ	denotes	contains
T4794	13791-13795	RB	denotes	also
T4795	13805-13808	DT	denotes	the
T4796	13821-13832	NNS	denotes	orthologues
T4797	13809-13811	NNP	denotes	T.
T4798	13812-13820	NNP	denotes	rubripes
T4799	13833-13835	IN	denotes	of
T4800	13836-13840	NN	denotes	MSX1
T4801	13840-13842	,	denotes	,
T4802	13842-13847	NN	denotes	STX18
T4803	13847-13849	,	denotes	,
T4804	13849-13856	NN	denotes	D4S234E
T4805	13857-13860	CC	denotes	and
T4806	13861-13864	DT	denotes	the
T4807	13875-13879	NN	denotes	gene
T4808	13865-13874	VBN	denotes	predicted
T4809	13880-13889	NN	denotes	LOC118711
T4810	13889-13891	,	denotes	,
T4811	13891-13893	IN	denotes	in
T4812	13894-13902	NN	denotes	addition
T4813	13903-13905	IN	denotes	to
T4814	13906-13915	NNS	denotes	sequences
T4815	13916-13920	IN	denotes	with
T4816	13921-13929	NN	denotes	homology
T4817	13930-13932	IN	denotes	to
T4818	13933-13937	NN	denotes	LOXL
T4819	13937-13939	,	denotes	,
T4820	13939-13942	NN	denotes	EVC
T4821	13942-13944	,	denotes	,
T4822	13944-13953	NN	denotes	LOC159291
T4823	13953-13955	,	denotes	,
T4824	13955-13958	CC	denotes	and
T4825	13959-13962	DT	denotes	the
T4826	13967-13973	NN	denotes	family
T4827	13963-13966	NN	denotes	LDB
T4828	13973-13974	.	denotes	.
T4829	13974-14272	sentence	denotes	Thus, scaffold 12 contains genes found in the regions of human chromosome 4 and 10 that also contain the loci for TACC3 and TACC2, respectively, and may therefore more closely resemble the genomic organization resulting from the initial duplication of the ancestral paralogous chromosomal segment.
T4830	13975-13979	RB	denotes	Thus
T4831	13993-14001	VBZ	denotes	contains
T4832	13979-13981	,	denotes	,
T4833	13981-13989	NN	denotes	scaffold
T4834	13990-13992	CD	denotes	12
T4835	14002-14007	NNS	denotes	genes
T4836	14008-14013	VBN	denotes	found
T4837	14014-14016	IN	denotes	in
T4838	14017-14020	DT	denotes	the
T4839	14021-14028	NNS	denotes	regions
T4840	14029-14031	IN	denotes	of
T4841	14032-14037	JJ	denotes	human
T4842	14049-14050	CD	denotes	4
T4843	14038-14048	NN	denotes	chromosome
T4844	14051-14054	CC	denotes	and
T4845	14055-14057	CD	denotes	10
T4846	14058-14062	WDT	denotes	that
T4847	14068-14075	VBP	denotes	contain
T4848	14063-14067	RB	denotes	also
T4849	14076-14079	DT	denotes	the
T4850	14080-14084	NNS	denotes	loci
T4851	14085-14088	IN	denotes	for
T4852	14089-14094	NN	denotes	TACC3
T4853	14095-14098	CC	denotes	and
T4854	14099-14104	NN	denotes	TACC2
T4855	14104-14106	,	denotes	,
T4856	14106-14118	RB	denotes	respectively
T4857	14118-14120	,	denotes	,
T4858	14120-14123	CC	denotes	and
T4859	14124-14127	MD	denotes	may
T4860	14151-14159	VB	denotes	resemble
T4861	14128-14137	RB	denotes	therefore
T4862	14138-14142	RBR	denotes	more
T4863	14143-14150	RB	denotes	closely
T4864	14160-14163	DT	denotes	the
T4865	14172-14184	NN	denotes	organization
T4866	14164-14171	JJ	denotes	genomic
T4867	14185-14194	VBG	denotes	resulting
T4868	14195-14199	IN	denotes	from
T4869	14200-14203	DT	denotes	the
T4870	14212-14223	NN	denotes	duplication
T4871	14204-14211	JJ	denotes	initial
T4872	14224-14226	IN	denotes	of
T4873	14227-14230	DT	denotes	the
T4874	14264-14271	NN	denotes	segment
T4875	14231-14240	JJ	denotes	ancestral
T4876	14241-14251	JJ	denotes	paralogous
T4877	14252-14263	JJ	denotes	chromosomal
T4878	14271-14272	.	denotes	.
T4879	14272-14402	sentence	denotes	Conserved paralogous clusters may result from the initial clustering of the genes in a relatively small ancestral genomic contig.
T4880	14273-14282	VBN	denotes	Conserved
T4881	14294-14302	NNS	denotes	clusters
T4882	14283-14293	JJ	denotes	paralogous
T4883	14307-14313	VB	denotes	result
T4884	14303-14306	MD	denotes	may
T4885	14314-14318	IN	denotes	from
T4886	14319-14322	DT	denotes	the
T4887	14331-14341	NN	denotes	clustering
T4888	14323-14330	JJ	denotes	initial
T4889	14342-14344	IN	denotes	of
T4890	14345-14348	DT	denotes	the
T4891	14349-14354	NNS	denotes	genes
T4892	14355-14357	IN	denotes	in
T4893	14358-14359	DT	denotes	a
T4894	14395-14401	NN	denotes	contig
T4895	14360-14370	RB	denotes	relatively
T4896	14371-14376	JJ	denotes	small
T4897	14377-14386	JJ	denotes	ancestral
T4898	14387-14394	JJ	denotes	genomic
T4899	14401-14402	.	denotes	.
T4900	14402-14608	sentence	denotes	Some evidence for the existence of "protoclusters" that could correspond to the paralogous chromosomal segments noted in higher vertebrates is present in the genome of the urochordate C. intestinalis [11].
T4901	14403-14407	DT	denotes	Some
T4902	14408-14416	NN	denotes	evidence
T4903	14543-14545	VBZ	denotes	is
T4904	14417-14420	IN	denotes	for
T4905	14421-14424	DT	denotes	the
T4906	14425-14434	NN	denotes	existence
T4907	14435-14437	IN	denotes	of
T4908	14438-14439	``	denotes	"
T4909	14439-14452	NNS	denotes	protoclusters
T4910	14452-14453	''	denotes	"
T4911	14454-14458	WDT	denotes	that
T4912	14465-14475	VB	denotes	correspond
T4913	14459-14464	MD	denotes	could
T4914	14476-14478	IN	denotes	to
T4915	14479-14482	DT	denotes	the
T4916	14506-14514	NNS	denotes	segments
T4917	14483-14493	JJ	denotes	paralogous
T4918	14494-14505	JJ	denotes	chromosomal
T4919	14515-14520	VBN	denotes	noted
T4920	14521-14523	IN	denotes	in
T4921	14524-14530	JJR	denotes	higher
T4922	14531-14542	NNS	denotes	vertebrates
T4923	14546-14553	JJ	denotes	present
T4924	14554-14556	IN	denotes	in
T4925	14557-14560	DT	denotes	the
T4926	14561-14567	NN	denotes	genome
T4927	14568-14570	IN	denotes	of
T4928	14571-14574	DT	denotes	the
T4929	14575-14586	NN	denotes	urochordate
T4930	14587-14589	NNP	denotes	C.
T4931	14590-14602	NNP	denotes	intestinalis
T4932	14603-14604	-LRB-	denotes	[
T4933	14604-14606	CD	denotes	11
T4934	14606-14607	-RRB-	denotes	]
T4935	14607-14608	.	denotes	.
T4936	14608-14876	sentence	denotes	For instance, the orthologues of FGFR, and WHSC1, carboxypeptidase Z and FLJ25359 cluster within an 85 kb region of the C. intestinalis genome and the human orthologues are still maintained in paralogous segments of 4p16, 8p and 10q (Fig. 3, [see Additional file 1]).
T4937	14609-14612	IN	denotes	For
T4938	14691-14698	VBP	denotes	cluster
T4939	14613-14621	NN	denotes	instance
T4940	14621-14623	,	denotes	,
T4941	14623-14626	DT	denotes	the
T4942	14627-14638	NNS	denotes	orthologues
T4943	14639-14641	IN	denotes	of
T4944	14642-14646	NN	denotes	FGFR
T4945	14646-14648	,	denotes	,
T4946	14648-14651	CC	denotes	and
T4947	14652-14657	NN	denotes	WHSC1
T4948	14657-14659	,	denotes	,
T4949	14659-14675	NN	denotes	carboxypeptidase
T4950	14676-14677	NN	denotes	Z
T4951	14678-14681	CC	denotes	and
T4952	14682-14690	NN	denotes	FLJ25359
T4953	14699-14705	IN	denotes	within
T4954	14706-14708	DT	denotes	an
T4955	14715-14721	NN	denotes	region
T4956	14709-14711	CD	denotes	85
T4957	14712-14714	NN	denotes	kb
T4958	14722-14724	IN	denotes	of
T4959	14725-14728	DT	denotes	the
T4960	14745-14751	NN	denotes	genome
T4961	14729-14731	NNP	denotes	C.
T4962	14732-14744	NNP	denotes	intestinalis
T4963	14752-14755	CC	denotes	and
T4964	14756-14759	DT	denotes	the
T4965	14766-14777	NNS	denotes	orthologues
T4966	14760-14765	JJ	denotes	human
T4967	14788-14798	VBN	denotes	maintained
T4968	14778-14781	VBP	denotes	are
T4969	14782-14787	RB	denotes	still
T4970	14799-14801	IN	denotes	in
T4971	14802-14812	JJ	denotes	paralogous
T4972	14813-14821	NNS	denotes	segments
T4973	14822-14824	IN	denotes	of
T4974	14825-14829	NN	denotes	4p16
T4975	14829-14831	,	denotes	,
T4976	14831-14833	NN	denotes	8p
T4977	14834-14837	CC	denotes	and
T4978	14838-14841	NN	denotes	10q
T4979	14842-14843	-LRB-	denotes	(
T4980	14843-14847	NN	denotes	Fig.
T4981	14848-14849	CD	denotes	3
T4982	14849-14851	,	denotes	,
T4983	14851-14852	-LRB-	denotes	[
T4984	14852-14855	VB	denotes	see
T4985	14856-14866	JJ	denotes	Additional
T4986	14867-14871	NN	denotes	file
T4987	14872-14873	CD	denotes	1
T4988	14873-14874	-RRB-	denotes	]
T4989	14874-14875	-RRB-	denotes	)
T4990	14875-14876	.	denotes	.
T4991	14876-15244	sentence	denotes	However, it should be noted that no clusters of genes from the vertebrate paralogous segments are locate close to the TACC or RHAMM genes of C. intestinalis, indicating that the formation of the much larger paralogous segments encompassing the FGFR-TACC genes formed later in evolutionary time, or conversely have been subject to extensive rearrangement in tunicates.
T4992	14877-14884	RB	denotes	However
T4993	14899-14904	VBN	denotes	noted
T4994	14884-14886	,	denotes	,
T4995	14886-14888	PRP	denotes	it
T4996	14889-14895	MD	denotes	should
T4997	14896-14898	VB	denotes	be
T4998	14905-14909	IN	denotes	that
T4999	14975-14981	VBN	denotes	locate
T5000	14910-14912	DT	denotes	no
T5001	14913-14921	NNS	denotes	clusters
T5002	14922-14924	IN	denotes	of
T5003	14925-14930	NNS	denotes	genes
T5004	14931-14935	IN	denotes	from
T5005	14936-14939	DT	denotes	the
T5006	14962-14970	NNS	denotes	segments
T5007	14940-14950	NN	denotes	vertebrate
T5008	14951-14961	JJ	denotes	paralogous
T5009	14971-14974	VBP	denotes	are
T5010	14982-14987	RB	denotes	close
T5011	14988-14990	IN	denotes	to
T5012	14991-14994	DT	denotes	the
T5013	15009-15014	NNS	denotes	genes
T5014	14995-14999	NN	denotes	TACC
T5015	15000-15002	CC	denotes	or
T5016	15003-15008	NN	denotes	RHAMM
T5017	15015-15017	IN	denotes	of
T5018	15018-15020	NNP	denotes	C.
T5019	15021-15033	NNP	denotes	intestinalis
T5020	15033-15035	,	denotes	,
T5021	15035-15045	VBG	denotes	indicating
T5022	15046-15050	IN	denotes	that
T5023	15137-15143	VBD	denotes	formed
T5024	15051-15054	DT	denotes	the
T5025	15055-15064	NN	denotes	formation
T5026	15065-15067	IN	denotes	of
T5027	15068-15071	DT	denotes	the
T5028	15095-15103	NNS	denotes	segments
T5029	15072-15076	RB	denotes	much
T5030	15077-15083	JJR	denotes	larger
T5031	15084-15094	JJ	denotes	paralogous
T5032	15104-15116	VBG	denotes	encompassing
T5033	15117-15120	DT	denotes	the
T5034	15131-15136	NNS	denotes	genes
T5035	15121-15125	NN	denotes	FGFR
T5036	15126-15130	NN	denotes	TACC
T5037	15125-15126	HYPH	denotes	-
T5038	15144-15149	RB	denotes	later
T5039	15150-15152	IN	denotes	in
T5040	15153-15165	JJ	denotes	evolutionary
T5041	15166-15170	NN	denotes	time
T5042	15170-15172	,	denotes	,
T5043	15172-15174	CC	denotes	or
T5044	15175-15185	RB	denotes	conversely
T5045	15191-15195	VBN	denotes	been
T5046	15186-15190	VBP	denotes	have
T5047	15196-15203	JJ	denotes	subject
T5048	15204-15206	IN	denotes	to
T5049	15207-15216	JJ	denotes	extensive
T5050	15217-15230	NN	denotes	rearrangement
T5051	15231-15233	IN	denotes	in
T5052	15234-15243	NNS	denotes	tunicates
T5053	15243-15244	.	denotes	.
T5054	15244-15601	sentence	denotes	In combination with the examination of the T. rubripes genome, this also provides additional evidence that either the second round of duplication of the chromosomal segment that contained the FGFR3/4 ancestor did not include a TACC gene, or that such a gene was lost very early in vertebrate evolution, prior to the divergence of the Gnanthostome lineages.
T5055	15245-15247	IN	denotes	In
T5056	15318-15326	VBZ	denotes	provides
T5057	15248-15259	NN	denotes	combination
T5058	15260-15264	IN	denotes	with
T5059	15265-15268	DT	denotes	the
T5060	15269-15280	NN	denotes	examination
T5061	15281-15283	IN	denotes	of
T5062	15284-15287	DT	denotes	the
T5063	15300-15306	NN	denotes	genome
T5064	15288-15290	NNP	denotes	T.
T5065	15291-15299	NNP	denotes	rubripes
T5066	15306-15308	,	denotes	,
T5067	15308-15312	DT	denotes	this
T5068	15313-15317	RB	denotes	also
T5069	15327-15337	JJ	denotes	additional
T5070	15338-15346	NN	denotes	evidence
T5071	15347-15351	IN	denotes	that
T5072	15462-15469	VB	denotes	include
T5073	15352-15358	CC	denotes	either
T5074	15359-15362	DT	denotes	the
T5075	15370-15375	NN	denotes	round
T5076	15363-15369	JJ	denotes	second
T5077	15376-15378	IN	denotes	of
T5078	15379-15390	NN	denotes	duplication
T5079	15391-15393	IN	denotes	of
T5080	15394-15397	DT	denotes	the
T5081	15410-15417	NN	denotes	segment
T5082	15398-15409	JJ	denotes	chromosomal
T5083	15418-15422	WDT	denotes	that
T5084	15423-15432	VBD	denotes	contained
T5085	15433-15436	DT	denotes	the
T5086	15445-15453	NN	denotes	ancestor
T5087	15437-15442	NN	denotes	FGFR3
T5088	15442-15443	HYPH	denotes	/
T5089	15443-15444	CD	denotes	4
T5090	15454-15457	VBD	denotes	did
T5091	15458-15461	RB	denotes	not
T5092	15470-15471	DT	denotes	a
T5093	15477-15481	NN	denotes	gene
T5094	15472-15476	NN	denotes	TACC
T5095	15481-15483	,	denotes	,
T5096	15483-15485	CC	denotes	or
T5097	15486-15490	IN	denotes	that
T5098	15507-15511	VBN	denotes	lost
T5099	15491-15495	PDT	denotes	such
T5100	15498-15502	NN	denotes	gene
T5101	15496-15497	DT	denotes	a
T5102	15503-15506	VBD	denotes	was
T5103	15512-15516	RB	denotes	very
T5104	15517-15522	RB	denotes	early
T5105	15523-15525	IN	denotes	in
T5106	15526-15536	NN	denotes	vertebrate
T5107	15537-15546	NN	denotes	evolution
T5108	15546-15548	,	denotes	,
T5109	15548-15553	RB	denotes	prior
T5110	15554-15556	IN	denotes	to
T5111	15557-15560	DT	denotes	the
T5112	15561-15571	NN	denotes	divergence
T5113	15572-15574	IN	denotes	of
T5114	15575-15578	DT	denotes	the
T5115	15592-15600	NNS	denotes	lineages
T5116	15579-15591	NNP	denotes	Gnanthostome
T5117	15600-15601	.	denotes	.
T5118	15601-15882	sentence	denotes	However, the final resolution of the initial evolution of these paralogous segment will await the sequencing of the amphioxus and lamprey genomes, which only have one FGFR gene, and therefore should only contain one copy of the other corresponding genes in this conserved segment.
T5119	15602-15609	RB	denotes	However
T5161	15836-15849	VBG	denotes	corresponding
T5162	15856-15858	IN	denotes	in
T5163	15859-15863	DT	denotes	this
T5164	15874-15881	NN	denotes	segment
T5165	15864-15873	VBN	denotes	conserved
T5166	15881-15882	.	denotes	.
T5507	17041-17052	JJ	denotes	Comparative
T5508	17061-17070	NN	denotes	structure
T5509	17053-17060	JJ	denotes	genomic
T5510	17071-17073	IN	denotes	of
T5511	17074-17077	DT	denotes	the
T5512	17083-17089	NN	denotes	family
T5513	17078-17082	NN	denotes	TACC
T5514	17089-17345	sentence	denotes	The genomic DNA sequences corresponding to the orthologous TACC genes of human, mouse, rat, pufferfish, C. intestinalis, D. melanogaster and C. elegans were extracted and analyzed by Genescan and BLAST to determine the genomic structure of each TACC gene.
T5515	17090-17093	DT	denotes	The
T5516	17106-17115	NNS	denotes	sequences
T5517	17094-17101	JJ	denotes	genomic
T5518	17102-17105	NN	denotes	DNA
T5519	17247-17256	VBN	denotes	extracted
T5520	17116-17129	VBG	denotes	corresponding
T5521	17130-17132	IN	denotes	to
T5522	17133-17136	DT	denotes	the
T5523	17154-17159	NNS	denotes	genes
T5524	17137-17148	JJ	denotes	orthologous
T5525	17149-17153	NN	denotes	TACC
T5526	17160-17162	IN	denotes	of
T5527	17163-17168	JJ	denotes	human
T5528	17168-17170	,	denotes	,
T5529	17170-17175	NN	denotes	mouse
T5530	17175-17177	,	denotes	,
T5531	17177-17180	NN	denotes	rat
T5532	17180-17182	,	denotes	,
T5533	17182-17192	NN	denotes	pufferfish
T5534	17192-17194	,	denotes	,
T5535	17194-17196	NNP	denotes	C.
T5536	17197-17209	NNP	denotes	intestinalis
T5537	17209-17211	,	denotes	,
T5538	17211-17213	NNP	denotes	D.
T5539	17214-17226	NNP	denotes	melanogaster
T5540	17227-17230	CC	denotes	and
T5541	17231-17233	NNP	denotes	C.
T5542	17234-17241	NNP	denotes	elegans
T5543	17242-17246	VBD	denotes	were
T5544	17257-17260	CC	denotes	and
T5545	17261-17269	VBN	denotes	analyzed
T5546	17270-17272	IN	denotes	by
T5547	17273-17281	NNP	denotes	Genescan
T5548	17282-17285	CC	denotes	and
T5549	17286-17291	NNP	denotes	BLAST
T5550	17292-17294	TO	denotes	to
T5551	17295-17304	VB	denotes	determine
T5552	17305-17308	DT	denotes	the
T5553	17317-17326	NN	denotes	structure
T5554	17309-17316	JJ	denotes	genomic
T5555	17327-17329	IN	denotes	of
T5556	17330-17334	DT	denotes	each
T5557	17340-17344	NN	denotes	gene
T5558	17335-17339	NN	denotes	TACC
T5559	17344-17345	.	denotes	.
T5560	17345-17512	sentence	denotes	In some cases, for rat and pufferfish, exons were added or modified based on the best similarity of translated peptides to the corresponding mouse and human proteins.
T5561	17346-17348	IN	denotes	In
T5562	17396-17401	VBN	denotes	added
T5563	17349-17353	DT	denotes	some
T5564	17354-17359	NNS	denotes	cases
T5565	17359-17361	,	denotes	,
T5566	17361-17364	IN	denotes	for
T5567	17365-17368	NN	denotes	rat
T5568	17369-17372	CC	denotes	and
T5569	17373-17383	NN	denotes	pufferfish
T5570	17383-17385	,	denotes	,
T5571	17385-17390	NNS	denotes	exons
T5572	17391-17395	VBD	denotes	were
T5573	17402-17404	CC	denotes	or
T5574	17405-17413	VBN	denotes	modified
T5575	17414-17419	VBN	denotes	based
T5576	17420-17422	IN	denotes	on
T5577	17423-17426	DT	denotes	the
T5578	17432-17442	NN	denotes	similarity
T5579	17427-17431	JJS	denotes	best
T5580	17443-17445	IN	denotes	of
T5581	17446-17456	VBN	denotes	translated
T5582	17457-17465	NNS	denotes	peptides
T5583	17466-17468	IN	denotes	to
T5584	17469-17472	DT	denotes	the
T5585	17503-17511	NN	denotes	proteins
T5586	17473-17486	VBG	denotes	corresponding
T5587	17487-17492	NN	denotes	mouse
T5588	17493-17496	CC	denotes	and
T5589	17497-17502	JJ	denotes	human
T5590	17511-17512	.	denotes	.
T5591	17512-17705	sentence	denotes	For regions with low sequence similarity in T. rubripes, genomic sequences from the fresh water pufferfish, Tetraodon nigroviridis were used as additional means to verify the predicted exons.
T5592	17513-17516	IN	denotes	For
T5593	17650-17654	VBN	denotes	used
T5594	17517-17524	NNS	denotes	regions
T5595	17525-17529	IN	denotes	with
T5596	17530-17533	JJ	denotes	low
T5597	17543-17553	NN	denotes	similarity
T5598	17534-17542	NN	denotes	sequence
T5599	17554-17556	IN	denotes	in
T5600	17557-17559	NNP	denotes	T.
T5601	17560-17568	NNP	denotes	rubripes
T5602	17568-17570	,	denotes	,
T5603	17570-17577	JJ	denotes	genomic
T5604	17578-17587	NNS	denotes	sequences
T5605	17589-17593	IN	denotes	from
T5606	17594-17597	DT	denotes	the
T5607	17610-17620	NN	denotes	pufferfish
T5608	17598-17603	JJ	denotes	fresh
T5609	17604-17609	NN	denotes	water
T5610	17620-17622	,	denotes	,
T5611	17622-17631	NNP	denotes	Tetraodon
T5612	17632-17644	NNP	denotes	nigroviridis
T5613	17645-17649	VBD	denotes	were
T5614	17655-17657	IN	denotes	as
T5615	17658-17668	JJ	denotes	additional
T5616	17669-17674	NNS	denotes	means
T5617	17675-17677	TO	denotes	to
T5618	17678-17684	VB	denotes	verify
T5619	17685-17688	DT	denotes	the
T5620	17699-17704	NNS	denotes	exons
T5621	17689-17698	VBN	denotes	predicted
T5622	17704-17705	.	denotes	.
T5623	17705-17781	sentence	denotes	The general structure of the TACC genes and proteins is depicted in Fig. 4.
T5624	17706-17709	DT	denotes	The
T5625	17718-17727	NN	denotes	structure
T5626	17710-17717	JJ	denotes	general
T5627	17762-17770	VBN	denotes	depicted
T5628	17728-17730	IN	denotes	of
T5629	17731-17734	DT	denotes	the
T5630	17740-17745	NNS	denotes	genes
T5631	17735-17739	NN	denotes	TACC
T5632	17746-17749	CC	denotes	and
T5633	17750-17758	NN	denotes	proteins
T5634	17759-17761	VBZ	denotes	is
T5635	17771-17773	IN	denotes	in
T5636	17774-17778	NN	denotes	Fig.
T5637	17779-17780	CD	denotes	4
T5638	17780-17781	.	denotes	.
T5639	17781-17896	sentence	denotes	The main conserved feature of the TACC family, the TACC domain, is located at the carboxy terminus of the protein.
T5640	17782-17785	DT	denotes	The
T5641	17801-17808	NN	denotes	feature
T5642	17786-17790	JJ	denotes	main
T5643	17791-17800	VBN	denotes	conserved
T5644	17849-17856	VBN	denotes	located
T5645	17809-17811	IN	denotes	of
T5646	17812-17815	DT	denotes	the
T5647	17821-17827	NN	denotes	family
T5648	17816-17820	NN	denotes	TACC
T5649	17827-17829	,	denotes	,
T5650	17829-17832	DT	denotes	the
T5651	17838-17844	NN	denotes	domain
T5652	17833-17837	NN	denotes	TACC
T5653	17844-17846	,	denotes	,
T5654	17846-17848	VBZ	denotes	is
T5655	17857-17859	IN	denotes	at
T5656	17860-17863	DT	denotes	the
T5657	17872-17880	NN	denotes	terminus
T5658	17864-17871	NN	denotes	carboxy
T5659	17881-17883	IN	denotes	of
T5660	17884-17887	DT	denotes	the
T5661	17888-17895	NN	denotes	protein
T5662	17895-17896	.	denotes	.
T5663	17896-18046	sentence	denotes	In the case of the C. elegans TAC protein, this structure comprises the majority of the protein and is encoded by two of the three exons of the gene.
T5664	17897-17899	IN	denotes	In
T5665	17955-17964	VBZ	denotes	comprises
T5666	17900-17903	DT	denotes	the
T5667	17904-17908	NN	denotes	case
T5668	17909-17911	IN	denotes	of
T5669	17912-17915	DT	denotes	the
T5670	17931-17938	NN	denotes	protein
T5671	17916-17918	NNP	denotes	C.
T5672	17919-17926	NNP	denotes	elegans
T5673	17927-17930	NN	denotes	TAC
T5674	17938-17940	,	denotes	,
T5675	17940-17944	DT	denotes	this
T5676	17945-17954	NN	denotes	structure
T5677	17965-17968	DT	denotes	the
T5678	17969-17977	NN	denotes	majority
T5679	17978-17980	IN	denotes	of
T5680	17981-17984	DT	denotes	the
T5681	17985-17992	NN	denotes	protein
T5682	17993-17996	CC	denotes	and
T5683	17997-17999	VBZ	denotes	is
T5684	18000-18007	VBN	denotes	encoded
T5685	18008-18010	IN	denotes	by
T5686	18011-18014	CD	denotes	two
T5687	18015-18017	IN	denotes	of
T5688	18018-18021	DT	denotes	the
T5689	18028-18033	NNS	denotes	exons
T5690	18022-18027	CD	denotes	three
T5691	18034-18036	IN	denotes	of
T5692	18037-18040	DT	denotes	the
T5693	18041-18045	NN	denotes	gene
T5694	18045-18046	.	denotes	.
T5695	18046-18256	sentence	denotes	In the higher organisms, D. melanogaster, and the deuterostomes C. intestinalis to human, this feature is also encoded by the final exons of the gene (five in D. melanogaster, seven in the deuterostome genes).
T5696	18047-18049	IN	denotes	In
T5697	18158-18165	VBN	denotes	encoded
T5698	18050-18053	DT	denotes	the
T5699	18061-18070	NNS	denotes	organisms
T5700	18054-18060	JJR	denotes	higher
T5701	18070-18072	,	denotes	,
T5702	18072-18074	NNP	denotes	D.
T5703	18075-18087	NNP	denotes	melanogaster
T5704	18087-18089	,	denotes	,
T5705	18089-18092	CC	denotes	and
T5706	18093-18096	DT	denotes	the
T5707	18114-18126	NNP	denotes	intestinalis
T5708	18097-18110	NNS	denotes	deuterostomes
T5709	18111-18113	NNP	denotes	C.
T5710	18127-18129	IN	denotes	to
T5711	18130-18135	JJ	denotes	human
T5712	18135-18137	,	denotes	,
T5713	18137-18141	DT	denotes	this
T5714	18142-18149	NN	denotes	feature
T5715	18150-18152	VBZ	denotes	is
T5716	18153-18157	RB	denotes	also
T5717	18166-18168	IN	denotes	by
T5718	18169-18172	DT	denotes	the
T5719	18179-18184	NNS	denotes	exons
T5720	18173-18178	JJ	denotes	final
T5721	18185-18187	IN	denotes	of
T5722	18188-18191	DT	denotes	the
T5723	18192-18196	NN	denotes	gene
T5724	18197-18198	-LRB-	denotes	(
T5725	18198-18202	CD	denotes	five
T5726	18203-18205	IN	denotes	in
T5727	18206-18208	NNP	denotes	D.
T5728	18209-18221	NNP	denotes	melanogaster
T5729	18221-18223	,	denotes	,
T5730	18223-18228	CD	denotes	seven
T5731	18229-18231	IN	denotes	in
T5732	18232-18235	DT	denotes	the
T5733	18249-18254	NNS	denotes	genes
T5734	18236-18248	NN	denotes	deuterostome
T5735	18254-18255	-RRB-	denotes	)
T5736	18255-18256	.	denotes	.
T5737	18256-18346	sentence	denotes	Outside of the TACC domain, however, TACC family members show relatively little homology.
T5738	18257-18264	IN	denotes	Outside
T5739	18314-18318	VBP	denotes	show
T5740	18265-18267	IN	denotes	of
T5741	18268-18271	DT	denotes	the
T5742	18277-18283	NN	denotes	domain
T5743	18272-18276	NN	denotes	TACC
T5744	18283-18285	,	denotes	,
T5745	18285-18292	RB	denotes	however
T5746	18292-18294	,	denotes	,
T5747	18294-18298	NN	denotes	TACC
T5748	18306-18313	NNS	denotes	members
T5749	18299-18305	NN	denotes	family
T5750	18319-18329	RB	denotes	relatively
T5751	18330-18336	JJ	denotes	little
T5752	18337-18345	NN	denotes	homology
T5753	18345-18346	.	denotes	.
T5754	18346-18564	sentence	denotes	It is interesting that each TACC gene contains one large exon, which shows considerable variability between TACC orthologues, and constitutes the main difference between the TACC3 genes in the vertebrates (see below).
T5755	18347-18349	PRP	denotes	It
T5756	18350-18352	VBZ	denotes	is
T5757	18353-18364	JJ	denotes	interesting
T5758	18365-18369	IN	denotes	that
T5759	18385-18393	VBZ	denotes	contains
T5760	18370-18374	DT	denotes	each
T5761	18380-18384	NN	denotes	gene
T5762	18375-18379	NN	denotes	TACC
T5763	18394-18397	CD	denotes	one
T5764	18404-18408	NN	denotes	exon
T5765	18398-18403	JJ	denotes	large
T5766	18408-18410	,	denotes	,
T5767	18410-18415	WDT	denotes	which
T5768	18416-18421	VBZ	denotes	shows
T5769	18422-18434	JJ	denotes	considerable
T5770	18435-18446	NN	denotes	variability
T5771	18447-18454	IN	denotes	between
T5772	18455-18459	NN	denotes	TACC
T5773	18460-18471	NNS	denotes	orthologues
T5774	18471-18473	,	denotes	,
T5775	18473-18476	CC	denotes	and
T5776	18477-18488	VBZ	denotes	constitutes
T5777	18489-18492	DT	denotes	the
T5778	18498-18508	NN	denotes	difference
T5779	18493-18497	JJ	denotes	main
T5780	18509-18516	IN	denotes	between
T5781	18517-18520	DT	denotes	the
T5782	18527-18532	NNS	denotes	genes
T5783	18521-18526	NN	denotes	TACC3
T5784	18533-18535	IN	denotes	in
T5785	18536-18539	DT	denotes	the
T5786	18540-18551	NNS	denotes	vertebrates
T5787	18552-18553	-LRB-	denotes	(
T5788	18553-18556	VB	denotes	see
T5789	18557-18562	RB	denotes	below
T5790	18562-18563	-RRB-	denotes	)
T5791	18563-18564	.	denotes	.
T5792	18564-18802	sentence	denotes	In deuterostomes, this exon contains the SDP repeat (or in the case of the murine TACC3's, a rodent-specific 24 amino acid repeat), which is responsible for the binding of the SWI/SNF chromatin remodeling complex component GAS41 [15,16].
T5793	18565-18567	IN	denotes	In
T5794	18593-18601	VBZ	denotes	contains
T5795	18568-18581	NNS	denotes	deuterostomes
T5796	18581-18583	,	denotes	,
T5797	18583-18587	DT	denotes	this
T5798	18588-18592	NN	denotes	exon
T5799	18602-18605	DT	denotes	the
T5800	18610-18616	NN	denotes	repeat
T5801	18606-18609	NN	denotes	SDP
T5802	18617-18618	-LRB-	denotes	(
T5803	18618-18620	CC	denotes	or
T5804	18621-18623	IN	denotes	in
T5805	18688-18694	NN	denotes	repeat
T5806	18624-18627	DT	denotes	the
T5807	18628-18632	NN	denotes	case
T5808	18633-18635	IN	denotes	of
T5809	18636-18639	DT	denotes	the
T5810	18647-18652	NN	denotes	TACC3
T5811	18640-18646	JJ	denotes	murine
T5812	18652-18654	POS	denotes	's
T5813	18654-18656	,	denotes	,
T5814	18656-18657	DT	denotes	a
T5815	18658-18664	NN	denotes	rodent
T5816	18665-18673	JJ	denotes	specific
T5817	18664-18665	HYPH	denotes	-
T5818	18674-18676	CD	denotes	24
T5819	18683-18687	NN	denotes	acid
T5820	18677-18682	NN	denotes	amino
T5821	18694-18695	-RRB-	denotes	)
T5822	18695-18697	,	denotes	,
T5823	18697-18702	WDT	denotes	which
T5824	18703-18705	VBZ	denotes	is
T5825	18706-18717	JJ	denotes	responsible
T5826	18718-18721	IN	denotes	for
T5827	18722-18725	DT	denotes	the
T5828	18726-18733	NN	denotes	binding
T5829	18734-18736	IN	denotes	of
T5830	18737-18740	DT	denotes	the
T5831	18778-18787	NN	denotes	component
T5832	18741-18744	NN	denotes	SWI
T5833	18745-18748	NN	denotes	SNF
T5834	18744-18745	HYPH	denotes	/
T5835	18749-18758	NN	denotes	chromatin
T5836	18759-18769	NN	denotes	remodeling
T5837	18770-18777	JJ	denotes	complex
T5838	18788-18793	NN	denotes	GAS41
T5839	18794-18795	-LRB-	denotes	[
T5840	18798-18800	CD	denotes	16
T5841	18795-18797	CD	denotes	15
T5842	18797-18798	,	denotes	,
T5843	18800-18801	-RRB-	denotes	]
T5844	18801-18802	.	denotes	.
T5845	18802-19020	sentence	denotes	Of the vertebrate TACC proteins, the TACC3 orthologues show the greatest variability in size and sequence, ranging in size from 599 amino acids for the rat TACC3 protein, to 942 amino acids in the Danio rerio protein.
T5846	18803-18805	IN	denotes	Of
T5847	18858-18862	VBP	denotes	show
T5848	18806-18809	DT	denotes	the
T5849	18826-18834	NN	denotes	proteins
T5850	18810-18820	NN	denotes	vertebrate
T5851	18821-18825	NN	denotes	TACC
T5852	18834-18836	,	denotes	,
T5853	18836-18839	DT	denotes	the
T5854	18846-18857	NNS	denotes	orthologues
T5855	18840-18845	NN	denotes	TACC3
T5856	18863-18866	DT	denotes	the
T5857	18876-18887	NN	denotes	variability
T5858	18867-18875	JJS	denotes	greatest
T5859	18888-18890	IN	denotes	in
T5860	18891-18895	NN	denotes	size
T5861	18896-18899	CC	denotes	and
T5862	18900-18908	NN	denotes	sequence
T5863	18908-18910	,	denotes	,
T5864	18910-18917	VBG	denotes	ranging
T5865	18918-18920	IN	denotes	in
T5866	18921-18925	NN	denotes	size
T5867	18926-18930	IN	denotes	from
T5868	18931-18934	CD	denotes	599
T5869	18941-18946	NNS	denotes	acids
T5870	18935-18940	NN	denotes	amino
T5871	18947-18950	IN	denotes	for
T5872	18951-18954	DT	denotes	the
T5873	18965-18972	NN	denotes	protein
T5874	18955-18958	NN	denotes	rat
T5875	18959-18964	NN	denotes	TACC3
T5876	18972-18974	,	denotes	,
T5877	18974-18976	IN	denotes	to
T5878	18977-18980	CD	denotes	942
T5879	18987-18992	NNS	denotes	acids
T5880	18981-18986	NN	denotes	amino
T5881	18993-18995	IN	denotes	in
T5882	18996-18999	DT	denotes	the
T5883	19012-19019	NN	denotes	protein
T5884	19000-19005	NNP	denotes	Danio
T5885	19006-19011	NNP	denotes	rerio
T5886	19019-19020	.	denotes	.
T5887	19020-19120	sentence	denotes	The reasons for these differences are apparent from the genomic structure of the TACC3 orthologues.
T5888	19021-19024	DT	denotes	The
T5889	19025-19032	NNS	denotes	reasons
T5890	19055-19058	VBP	denotes	are
T5891	19033-19036	IN	denotes	for
T5892	19037-19042	DT	denotes	these
T5893	19043-19054	NNS	denotes	differences
T5894	19059-19067	JJ	denotes	apparent
T5895	19068-19072	IN	denotes	from
T5896	19073-19076	DT	denotes	the
T5897	19085-19094	NN	denotes	structure
T5898	19077-19084	JJ	denotes	genomic
T5899	19095-19097	IN	denotes	of
T5900	19098-19101	DT	denotes	the
T5901	19108-19119	NNS	denotes	orthologues
T5902	19102-19107	NN	denotes	TACC3
T5903	19119-19120	.	denotes	.
T5904	19120-19379	sentence	denotes	TACC3 can be divided into three sections: a conserved N-terminal region (CNTR) of 108 amino acids, encoded by exons 2 and 3 in each vertebrate TACC3 gene, the conserved TACC domain distributed over the final seven exons, and a highly variable central region.
T5905	19121-19126	NN	denotes	TACC3
T5906	19134-19141	VBN	denotes	divided
T5907	19127-19130	MD	denotes	can
T5908	19131-19133	VB	denotes	be
T5909	19142-19146	IN	denotes	into
T5910	19147-19152	CD	denotes	three
T5911	19153-19161	NNS	denotes	sections
T5912	19161-19163	:	denotes	:
T5913	19163-19164	DT	denotes	a
T5914	19186-19192	NN	denotes	region
T5915	19165-19174	VBN	denotes	conserved
T5916	19175-19176	NN	denotes	N
T5917	19177-19185	JJ	denotes	terminal
T5918	19176-19177	HYPH	denotes	-
T5919	19193-19194	-LRB-	denotes	(
T5920	19194-19198	NN	denotes	CNTR
T5921	19198-19199	-RRB-	denotes	)
T5922	19200-19202	IN	denotes	of
T5923	19203-19206	CD	denotes	108
T5924	19213-19218	NNS	denotes	acids
T5925	19207-19212	NN	denotes	amino
T5926	19218-19220	,	denotes	,
T5927	19220-19227	VBN	denotes	encoded
T5928	19228-19230	IN	denotes	by
T5929	19231-19236	NNS	denotes	exons
T5930	19237-19238	CD	denotes	2
T5931	19239-19242	CC	denotes	and
T5932	19243-19244	CD	denotes	3
T5933	19245-19247	IN	denotes	in
T5934	19248-19252	DT	denotes	each
T5935	19270-19274	NN	denotes	gene
T5936	19253-19263	NN	denotes	vertebrate
T5937	19264-19269	NN	denotes	TACC3
T5938	19274-19276	,	denotes	,
T5939	19276-19279	DT	denotes	the
T5940	19295-19301	NN	denotes	domain
T5941	19280-19289	VBN	denotes	conserved
T5942	19290-19294	NN	denotes	TACC
T5943	19302-19313	VBN	denotes	distributed
T5944	19314-19318	IN	denotes	over
T5945	19319-19322	DT	denotes	the
T5946	19335-19340	NNS	denotes	exons
T5947	19323-19328	JJ	denotes	final
T5948	19329-19334	CD	denotes	seven
T5949	19340-19342	,	denotes	,
T5950	19342-19345	CC	denotes	and
T5951	19346-19347	DT	denotes	a
T5952	19372-19378	NN	denotes	region
T5953	19348-19354	RB	denotes	highly
T5954	19355-19363	JJ	denotes	variable
T5955	19364-19371	JJ	denotes	central
T5956	19378-19379	.	denotes	.
T5957	19379-19594	sentence	denotes	The lack of conservation in both size and sequence of the central portion of the TACC3 proteins of human and mouse has been previously noted, and accounts for the major difference between these two orthologues [2].
T5958	19380-19383	DT	denotes	The
T5959	19384-19388	NN	denotes	lack
T5960	19515-19520	VBN	denotes	noted
T5961	19389-19391	IN	denotes	of
T5962	19392-19404	NN	denotes	conservation
T5963	19405-19407	IN	denotes	in
T5964	19408-19412	CC	denotes	both
T5965	19413-19417	NN	denotes	size
T5966	19418-19421	CC	denotes	and
T5967	19422-19430	NN	denotes	sequence
T5968	19431-19433	IN	denotes	of
T5969	19434-19437	DT	denotes	the
T5970	19446-19453	NN	denotes	portion
T5971	19438-19445	JJ	denotes	central
T5972	19454-19456	IN	denotes	of
T5973	19457-19460	DT	denotes	the
T5974	19467-19475	NN	denotes	proteins
T5975	19461-19466	NN	denotes	TACC3
T5976	19476-19478	IN	denotes	of
T5977	19479-19484	JJ	denotes	human
T5978	19489-19494	NN	denotes	mouse
T5979	19485-19488	CC	denotes	and
T5980	19495-19498	VBZ	denotes	has
T5981	19499-19503	VBN	denotes	been
T5982	19504-19514	RB	denotes	previously
T5983	19520-19522	,	denotes	,
T5984	19522-19525	CC	denotes	and
T5985	19526-19534	VBZ	denotes	accounts
T5986	19535-19538	IN	denotes	for
T5987	19539-19542	DT	denotes	the
T5988	19549-19559	NN	denotes	difference
T5989	19543-19548	JJ	denotes	major
T5990	19560-19567	IN	denotes	between
T5991	19568-19573	DT	denotes	these
T5992	19578-19589	NNS	denotes	orthologues
T5993	19574-19577	CD	denotes	two
T5994	19590-19591	-LRB-	denotes	[
T5995	19591-19592	CD	denotes	2
T5996	19592-19593	-RRB-	denotes	]
T5997	19593-19594	.	denotes	.
T5998	19594-19741	sentence	denotes	The majority of this central portion, which contains the SDP repeat motifs, is encoded by one exon in human and the pufferfish (emb\|CAAB01001184).
T5999	19595-19598	DT	denotes	The
T6000	19599-19607	NN	denotes	majority
T6001	19674-19681	VBN	denotes	encoded
T6002	19608-19610	IN	denotes	of
T6003	19611-19615	DT	denotes	this
T6004	19624-19631	NN	denotes	portion
T6005	19616-19623	JJ	denotes	central
T6006	19631-19633	,	denotes	,
T6007	19633-19638	WDT	denotes	which
T6008	19639-19647	VBZ	denotes	contains
T6009	19648-19651	DT	denotes	the
T6010	19663-19669	NNS	denotes	motifs
T6011	19652-19655	NN	denotes	SDP
T6012	19656-19662	NN	denotes	repeat
T6013	19669-19671	,	denotes	,
T6014	19671-19673	VBZ	denotes	is
T6015	19682-19684	IN	denotes	by
T6016	19685-19688	CD	denotes	one
T6017	19689-19693	NN	denotes	exon
T6018	19694-19696	IN	denotes	in
T6019	19697-19702	JJ	denotes	human
T6020	19703-19706	CC	denotes	and
T6021	19707-19710	DT	denotes	the
T6022	19711-19721	NN	denotes	pufferfish
T6023	19722-19723	-LRB-	denotes	(
T6024	19723-19739	NN	denotes	emb\|CAAB01001184
T6025	19739-19740	-RRB-	denotes	)
T6026	19740-19741	.	denotes	.
T6027	19741-19903	sentence	denotes	In rodents, however, this region is almost entirely composed of seven 24 amino acid repeats, which are located in a single exon of the mouse and rat TACC3 genes.
T6028	19742-19744	IN	denotes	In
T6029	19794-19802	VBN	denotes	composed
T6030	19745-19752	NNS	denotes	rodents
T6031	19752-19754	,	denotes	,
T6032	19754-19761	RB	denotes	however
T6033	19761-19763	,	denotes	,
T6034	19763-19767	DT	denotes	this
T6035	19768-19774	NN	denotes	region
T6036	19775-19777	VBZ	denotes	is
T6037	19778-19784	RB	denotes	almost
T6038	19785-19793	RB	denotes	entirely
T6039	19803-19805	IN	denotes	of
T6040	19806-19811	CD	denotes	seven
T6041	19826-19833	NNS	denotes	repeats
T6042	19812-19814	CD	denotes	24
T6043	19821-19825	NN	denotes	acid
T6044	19815-19820	NN	denotes	amino
T6045	19833-19835	,	denotes	,
T6046	19835-19840	WDT	denotes	which
T6047	19845-19852	VBN	denotes	located
T6048	19841-19844	VBP	denotes	are
T6049	19853-19855	IN	denotes	in
T6050	19856-19857	DT	denotes	a
T6051	19865-19869	NN	denotes	exon
T6052	19858-19864	JJ	denotes	single
T6053	19870-19872	IN	denotes	of
T6054	19873-19876	DT	denotes	the
T6055	19897-19902	NNS	denotes	genes
T6056	19877-19882	NN	denotes	mouse
T6057	19883-19886	CC	denotes	and
T6058	19887-19890	NN	denotes	rat
T6059	19891-19896	NN	denotes	TACC3
T6060	19902-19903	.	denotes	.
T6061	19903-20036	sentence	denotes	It has been previously reported that there are four mouse TACC3 splice variants that differ in the number of these repeats [2,7,17].
T6062	19904-19906	PRP	denotes	It
T6063	19927-19935	VBN	denotes	reported
T6064	19907-19910	VBZ	denotes	has
T6065	19911-19915	VBN	denotes	been
T6066	19916-19926	RB	denotes	previously
T6067	19936-19940	IN	denotes	that
T6068	19947-19950	VBP	denotes	are
T6069	19941-19946	EX	denotes	there
T6070	19951-19955	CD	denotes	four
T6071	19975-19983	NNS	denotes	variants
T6072	19956-19961	NN	denotes	mouse
T6073	19962-19967	NN	denotes	TACC3
T6074	19968-19974	NN	denotes	splice
T6075	19984-19988	WDT	denotes	that
T6076	19989-19995	VBP	denotes	differ
T6077	19996-19998	IN	denotes	in
T6078	19999-20002	DT	denotes	the
T6079	20003-20009	NN	denotes	number
T6080	20010-20012	IN	denotes	of
T6081	20013-20018	DT	denotes	these
T6082	20019-20026	NNS	denotes	repeats
T6083	20027-20028	-LRB-	denotes	[
T6084	20032-20034	CD	denotes	17
T6085	20028-20029	CD	denotes	2
T6086	20029-20030	,	denotes	,
T6087	20030-20031	CD	denotes	7
T6088	20031-20032	,	denotes	,
T6089	20034-20035	-RRB-	denotes	]
T6090	20035-20036	.	denotes	.
T6091	20036-20257	sentence	denotes	As these repeats are present in a single exon, it appears likely that these different sequences may be the result of the DNA polymerases used in the cDNA synthesis and/or PCR reaction stuttering through the repeat motif.
T6092	20037-20039	IN	denotes	As
T6093	20054-20057	VBP	denotes	are
T6094	20040-20045	DT	denotes	these
T6095	20046-20053	NNS	denotes	repeats
T6096	20087-20094	VBZ	denotes	appears
T6097	20058-20065	JJ	denotes	present
T6098	20066-20068	IN	denotes	in
T6099	20069-20070	DT	denotes	a
T6100	20078-20082	NN	denotes	exon
T6101	20071-20077	JJ	denotes	single
T6102	20082-20084	,	denotes	,
T6103	20084-20086	PRP	denotes	it
T6104	20095-20101	JJ	denotes	likely
T6105	20102-20106	IN	denotes	that
T6106	20137-20139	VB	denotes	be
T6107	20107-20112	DT	denotes	these
T6108	20123-20132	NNS	denotes	sequences
T6109	20113-20122	JJ	denotes	different
T6110	20133-20136	MD	denotes	may
T6111	20140-20143	DT	denotes	the
T6112	20144-20150	NN	denotes	result
T6113	20151-20153	IN	denotes	of
T6114	20154-20157	DT	denotes	the
T6115	20162-20173	NNS	denotes	polymerases
T6116	20158-20161	NN	denotes	DNA
T6117	20174-20178	VBN	denotes	used
T6118	20179-20181	IN	denotes	in
T6119	20182-20185	DT	denotes	the
T6120	20191-20200	NN	denotes	synthesis
T6121	20186-20190	NN	denotes	cDNA
T6122	20201-20204	CC	denotes	and
T6123	20204-20205	HYPH	denotes	/
T6124	20205-20207	CC	denotes	or
T6125	20208-20211	NN	denotes	PCR
T6126	20212-20220	NN	denotes	reaction
T6127	20221-20231	VBG	denotes	stuttering
T6128	20232-20239	IN	denotes	through
T6129	20240-20243	DT	denotes	the
T6130	20251-20256	NN	denotes	motif
T6131	20244-20250	NN	denotes	repeat
T6132	20256-20257	.	denotes	.
T6133	20257-20368	sentence	denotes	The correct sequence, reported by Sadek et al [7], is the one used throughout the entirety of this manuscript.
T6134	20258-20261	DT	denotes	The
T6135	20270-20278	NN	denotes	sequence
T6136	20262-20269	JJ	denotes	correct
T6137	20309-20311	VBZ	denotes	is
T6138	20278-20280	,	denotes	,
T6139	20280-20288	VBN	denotes	reported
T6140	20289-20291	IN	denotes	by
T6141	20292-20297	NNP	denotes	Sadek
T6142	20298-20300	FW	denotes	et
T6143	20301-20303	FW	denotes	al
T6144	20304-20305	-LRB-	denotes	[
T6145	20305-20306	CD	denotes	7
T6146	20306-20307	-RRB-	denotes	]
T6147	20307-20309	,	denotes	,
T6148	20312-20315	DT	denotes	the
T6149	20316-20319	CD	denotes	one
T6150	20320-20324	VBN	denotes	used
T6151	20325-20335	IN	denotes	throughout
T6152	20336-20339	DT	denotes	the
T6153	20340-20348	NN	denotes	entirety
T6154	20349-20351	IN	denotes	of
T6155	20352-20356	DT	denotes	this
T6156	20357-20367	NN	denotes	manuscript
T6157	20367-20368	.	denotes	.
T6158	20368-20590	sentence	denotes	These repeats are not evident in the rabbit protein, or any other TACC protein, and may indicate that the rodent TACC3 has evolved distinct functions, as has already been noted for the amphibian Xenopus TACC3, maskin [8].
T6159	20369-20374	DT	denotes	These
T6160	20375-20382	NNS	denotes	repeats
T6161	20383-20386	VBP	denotes	are
T6162	20387-20390	RB	denotes	not
T6163	20391-20398	JJ	denotes	evident
T6164	20399-20401	IN	denotes	in
T6165	20402-20405	DT	denotes	the
T6166	20413-20420	NN	denotes	protein
T6167	20406-20412	NN	denotes	rabbit
T6168	20420-20422	,	denotes	,
T6169	20422-20424	CC	denotes	or
T6170	20425-20428	DT	denotes	any
T6171	20440-20447	NN	denotes	protein
T6172	20429-20434	JJ	denotes	other
T6173	20435-20439	NN	denotes	TACC
T6174	20447-20449	,	denotes	,
T6175	20449-20452	CC	denotes	and
T6176	20453-20456	MD	denotes	may
T6177	20457-20465	VB	denotes	indicate
T6178	20466-20470	IN	denotes	that
T6179	20492-20499	VBN	denotes	evolved
T6180	20471-20474	DT	denotes	the
T6181	20482-20487	NN	denotes	TACC3
T6182	20475-20481	NN	denotes	rodent
T6183	20488-20491	VBZ	denotes	has
T6184	20500-20508	JJ	denotes	distinct
T6185	20509-20518	NNS	denotes	functions
T6186	20518-20520	,	denotes	,
T6187	20520-20522	IN	denotes	as
T6188	20540-20545	VBN	denotes	noted
T6189	20523-20526	VBZ	denotes	has
T6190	20527-20534	RB	denotes	already
T6191	20535-20539	VBN	denotes	been
T6192	20546-20549	IN	denotes	for
T6193	20550-20553	DT	denotes	the
T6194	20572-20577	NN	denotes	TACC3
T6195	20554-20563	JJ	denotes	amphibian
T6196	20564-20571	NNP	denotes	Xenopus
T6197	20577-20579	,	denotes	,
T6198	20579-20585	NN	denotes	maskin
T6199	20586-20587	-LRB-	denotes	[
T6200	20587-20588	CD	denotes	8
T6201	20588-20589	-RRB-	denotes	]
T6202	20589-20590	.	denotes	.
T6381	20592-20603	JJ	denotes	Alternative
T6382	20604-20612	NN	denotes	splicing
T6383	20613-20615	IN	denotes	in
T6384	20616-20626	NN	denotes	vertebrate
T6385	20632-20637	NNS	denotes	genes
T6386	20627-20631	NN	denotes	TACC
T6387	20637-20909	sentence	denotes	Whereas exon shuffling can drive the functional diversification of gene families over evolutionary time, the temporal and/or tissue specific alternative splicing of a gene can give rise to functional diversification of a single gene during the development of an organism.
T6388	20638-20645	IN	denotes	Whereas
T6389	20665-20670	VB	denotes	drive
T6390	20646-20650	NN	denotes	exon
T6391	20651-20660	NN	denotes	shuffling
T6392	20661-20664	MD	denotes	can
T6393	20814-20818	VB	denotes	give
T6394	20671-20674	DT	denotes	the
T6395	20686-20701	NN	denotes	diversification
T6396	20675-20685	JJ	denotes	functional
T6397	20702-20704	IN	denotes	of
T6398	20705-20709	NN	denotes	gene
T6399	20710-20718	NNS	denotes	families
T6400	20719-20723	IN	denotes	over
T6401	20724-20736	JJ	denotes	evolutionary
T6402	20737-20741	NN	denotes	time
T6403	20741-20743	,	denotes	,
T6404	20743-20746	DT	denotes	the
T6405	20791-20799	NN	denotes	splicing
T6406	20747-20755	JJ	denotes	temporal
T6407	20756-20759	CC	denotes	and
T6408	20759-20760	HYPH	denotes	/
T6409	20760-20762	CC	denotes	or
T6410	20763-20769	NN	denotes	tissue
T6411	20770-20778	JJ	denotes	specific
T6412	20779-20790	JJ	denotes	alternative
T6413	20800-20802	IN	denotes	of
T6414	20803-20804	DT	denotes	a
T6415	20805-20809	NN	denotes	gene
T6416	20810-20813	MD	denotes	can
T6417	20819-20823	NN	denotes	rise
T6418	20824-20826	IN	denotes	to
T6419	20827-20837	JJ	denotes	functional
T6420	20838-20853	NN	denotes	diversification
T6421	20854-20856	IN	denotes	of
T6422	20857-20858	DT	denotes	a
T6423	20866-20870	NN	denotes	gene
T6424	20859-20865	JJ	denotes	single
T6425	20871-20877	IN	denotes	during
T6426	20878-20881	DT	denotes	the
T6427	20882-20893	NN	denotes	development
T6428	20894-20896	IN	denotes	of
T6429	20897-20899	DT	denotes	an
T6430	20900-20908	NN	denotes	organism
T6431	20908-20909	.	denotes	.
T6432	20909-21065	sentence	denotes	Although no alternative splicing of TACC3 has been clearly documented, both temporal and tissue specific splicing is observed in the TACC1 and TACC2 genes.
T6433	20910-20918	IN	denotes	Although
T6434	20969-20979	VBN	denotes	documented
T6435	20919-20921	DT	denotes	no
T6436	20934-20942	NN	denotes	splicing
T6437	20922-20933	JJ	denotes	alternative
T6438	20943-20945	IN	denotes	of
T6439	20946-20951	NN	denotes	TACC3
T6440	20952-20955	VBZ	denotes	has
T6441	20956-20960	VBN	denotes	been
T6442	20961-20968	RB	denotes	clearly
T6443	21027-21035	VBN	denotes	observed
T6444	20979-20981	,	denotes	,
T6445	20981-20985	CC	denotes	both
T6446	20986-20994	JJ	denotes	temporal
T6447	21015-21023	NN	denotes	splicing
T6448	20995-20998	CC	denotes	and
T6449	20999-21005	NN	denotes	tissue
T6450	21006-21014	JJ	denotes	specific
T6451	21024-21026	VBZ	denotes	is
T6452	21036-21038	IN	denotes	in
T6453	21039-21042	DT	denotes	the
T6454	21059-21064	NNS	denotes	genes
T6455	21043-21048	NN	denotes	TACC1
T6456	21049-21052	CC	denotes	and
T6457	21053-21058	NN	denotes	TACC2
T6458	21064-21065	.	denotes	.
T6459	21065-21221	sentence	denotes	In the case of TACC2, an additional large (5 kb) exon accounts for the main difference between the major splice variants of the vertebrate TACC2 genes [3].
T6460	21066-21068	IN	denotes	In
T6461	21120-21128	VBZ	denotes	accounts
T6462	21069-21072	DT	denotes	the
T6463	21073-21077	NN	denotes	case
T6464	21078-21080	IN	denotes	of
T6465	21081-21086	NN	denotes	TACC2
T6466	21086-21088	,	denotes	,
T6467	21088-21090	DT	denotes	an
T6468	21115-21119	NN	denotes	exon
T6469	21091-21101	JJ	denotes	additional
T6470	21102-21107	JJ	denotes	large
T6471	21108-21109	-LRB-	denotes	(
T6472	21111-21113	NN	denotes	kb
T6473	21109-21110	CD	denotes	5
T6474	21113-21114	-RRB-	denotes	)
T6475	21129-21132	IN	denotes	for
T6476	21133-21136	DT	denotes	the
T6477	21142-21152	NN	denotes	difference
T6478	21137-21141	JJ	denotes	main
T6479	21153-21160	IN	denotes	between
T6480	21161-21164	DT	denotes	the
T6481	21178-21186	NNS	denotes	variants
T6482	21165-21170	JJ	denotes	major
T6483	21171-21177	NN	denotes	splice
T6484	21187-21189	IN	denotes	of
T6485	21190-21193	DT	denotes	the
T6486	21211-21216	NNS	denotes	genes
T6487	21194-21204	NN	denotes	vertebrate
T6488	21205-21210	NN	denotes	TACC2
T6489	21217-21218	-LRB-	denotes	[
T6490	21218-21219	CD	denotes	3
T6491	21219-21220	-RRB-	denotes	]
T6492	21220-21221	.	denotes	.
T6493	21221-21448	sentence	denotes	The alternative splicing of this exon suggests a major functional difference between the two TACC2 isoforms, TACC2s and TACC2l [3], as well as a significant difference between TACC2 and its closest TACC family relative, TACC1.
T6494	21222-21225	DT	denotes	The
T6495	21238-21246	NN	denotes	splicing
T6496	21226-21237	JJ	denotes	alternative
T6497	21260-21268	VBZ	denotes	suggests
T6498	21247-21249	IN	denotes	of
T6499	21250-21254	DT	denotes	this
T6500	21255-21259	NN	denotes	exon
T6501	21269-21270	DT	denotes	a
T6502	21288-21298	NN	denotes	difference
T6503	21271-21276	JJ	denotes	major
T6504	21277-21287	JJ	denotes	functional
T6505	21299-21306	IN	denotes	between
T6506	21307-21310	DT	denotes	the
T6507	21321-21329	NNS	denotes	isoforms
T6508	21311-21314	CD	denotes	two
T6509	21315-21320	NN	denotes	TACC2
T6510	21329-21331	,	denotes	,
T6511	21331-21337	NNS	denotes	TACC2s
T6512	21338-21341	CC	denotes	and
T6513	21342-21348	NN	denotes	TACC2l
T6514	21349-21350	-LRB-	denotes	[
T6515	21350-21351	CD	denotes	3
T6516	21351-21352	-RRB-	denotes	]
T6517	21352-21354	,	denotes	,
T6518	21354-21356	RB	denotes	as
T6519	21362-21364	IN	denotes	as
T6520	21357-21361	RB	denotes	well
T6521	21365-21366	DT	denotes	a
T6522	21379-21389	NN	denotes	difference
T6523	21367-21378	JJ	denotes	significant
T6524	21390-21397	IN	denotes	between
T6525	21398-21403	NN	denotes	TACC2
T6526	21404-21407	CC	denotes	and
T6527	21408-21411	PRP$	denotes	its
T6528	21432-21440	NN	denotes	relative
T6529	21412-21419	JJS	denotes	closest
T6530	21420-21424	NN	denotes	TACC
T6531	21425-21431	NN	denotes	family
T6532	21440-21442	,	denotes	,
T6533	21442-21447	NN	denotes	TACC1
T6534	21447-21448	.	denotes	.
T6535	21448-21527	sentence	denotes	However, the function of this region of the TACC2l isoform is current unknown.
T6536	21449-21456	RB	denotes	However
T6537	21508-21510	VBZ	denotes	is
T6538	21456-21458	,	denotes	,
T6539	21458-21461	DT	denotes	the
T6540	21462-21470	NN	denotes	function
T6541	21471-21473	IN	denotes	of
T6542	21474-21478	DT	denotes	this
T6543	21479-21485	NN	denotes	region
T6544	21486-21488	IN	denotes	of
T6545	21489-21492	DT	denotes	the
T6546	21500-21507	NN	denotes	isoform
T6547	21493-21499	NN	denotes	TACC2l
T6548	21511-21518	RB	denotes	current
T6549	21519-21526	JJ	denotes	unknown
T6550	21526-21527	.	denotes	.
T6551	21527-21648	sentence	denotes	Alternative splicing, together with differential promoter usage has already been noted for the human TACC1 gene [18,19].
T6552	21528-21539	JJ	denotes	Alternative
T6553	21540-21548	NN	denotes	splicing
T6554	21609-21614	VBN	denotes	noted
T6555	21548-21550	,	denotes	,
T6556	21550-21558	RB	denotes	together
T6557	21559-21563	IN	denotes	with
T6558	21564-21576	JJ	denotes	differential
T6559	21586-21591	NN	denotes	usage
T6560	21577-21585	NN	denotes	promoter
T6561	21592-21595	VBZ	denotes	has
T6562	21596-21603	RB	denotes	already
T6563	21604-21608	VBN	denotes	been
T6564	21615-21618	IN	denotes	for
T6565	21619-21622	DT	denotes	the
T6566	21635-21639	NN	denotes	gene
T6567	21623-21628	JJ	denotes	human
T6568	21629-21634	NN	denotes	TACC1
T6569	21640-21641	-LRB-	denotes	[
T6570	21644-21646	CD	denotes	19
T6571	21641-21643	CD	denotes	18
T6572	21643-21644	,	denotes	,
T6573	21646-21647	-RRB-	denotes	]
T6574	21647-21648	.	denotes	.
T6575	21648-21780	sentence	denotes	In addition, as shown in Fig. 5, we have identified additional TACC1 isoforms that result from alternative splicing of exons 1b-4a.
T6576	21649-21651	IN	denotes	In
T6577	21690-21700	VBN	denotes	identified
T6578	21652-21660	NN	denotes	addition
T6579	21660-21662	,	denotes	,
T6580	21662-21664	IN	denotes	as
T6581	21665-21670	VBN	denotes	shown
T6582	21671-21673	IN	denotes	in
T6583	21674-21678	NN	denotes	Fig.
T6584	21679-21680	CD	denotes	5
T6585	21680-21682	,	denotes	,
T6586	21682-21684	PRP	denotes	we
T6587	21685-21689	VBP	denotes	have
T6588	21701-21711	JJ	denotes	additional
T6589	21718-21726	NNS	denotes	isoforms
T6590	21712-21717	NN	denotes	TACC1
T6591	21727-21731	WDT	denotes	that
T6592	21732-21738	VBP	denotes	result
T6593	21739-21743	IN	denotes	from
T6594	21744-21755	JJ	denotes	alternative
T6595	21756-21764	NN	denotes	splicing
T6596	21765-21767	IN	denotes	of
T6597	21768-21773	NNS	denotes	exons
T6598	21777-21779	CD	denotes	4a
T6599	21774-21776	CD	denotes	1b
T6600	21776-21777	HYPH	denotes	-
T6601	21779-21780	.	denotes	.
T6602	21780-22064	sentence	denotes	The functions of these different isoforms are unknown, however the region deleted from the shorter variants can include the binding site for LSm7 [20] (variants C, D, F-I), and/or the nuclear localization signals and binding site for GAS41 [15] and PCTAIRE2BP [20] (isoforms B-D, S).
T6603	21781-21784	DT	denotes	The
T6604	21785-21794	NNS	denotes	functions
T6605	21823-21826	VBP	denotes	are
T6606	21795-21797	IN	denotes	of
T6607	21798-21803	DT	denotes	these
T6608	21814-21822	NNS	denotes	isoforms
T6609	21804-21813	JJ	denotes	different
T6610	21893-21900	VB	denotes	include
T6611	21827-21834	JJ	denotes	unknown
T6612	21834-21836	,	denotes	,
T6613	21836-21843	RB	denotes	however
T6614	21844-21847	DT	denotes	the
T6615	21848-21854	NN	denotes	region
T6616	21855-21862	VBN	denotes	deleted
T6617	21863-21867	IN	denotes	from
T6618	21868-21871	DT	denotes	the
T6619	21880-21888	NNS	denotes	variants
T6620	21872-21879	JJR	denotes	shorter
T6621	21889-21892	MD	denotes	can
T6622	21901-21904	DT	denotes	the
T6623	21913-21917	NN	denotes	site
T6624	21905-21912	NN	denotes	binding
T6625	21918-21921	IN	denotes	for
T6626	21922-21926	NN	denotes	LSm7
T6627	21927-21928	-LRB-	denotes	[
T6628	21928-21930	CD	denotes	20
T6629	21930-21931	-RRB-	denotes	]
T6630	21932-21933	-LRB-	denotes	(
T6631	21942-21943	NN	denotes	C
T6632	21933-21941	NNS	denotes	variants
T6633	21943-21945	,	denotes	,
T6634	21945-21946	NN	denotes	D
T6635	21946-21948	,	denotes	,
T6636	21948-21949	NN	denotes	F
T6637	21949-21950	SYM	denotes	-
T6638	21950-21951	NN	denotes	I
T6639	21951-21952	-RRB-	denotes	)
T6640	21952-21954	,	denotes	,
T6641	21954-21957	CC	denotes	and
T6642	21957-21958	HYPH	denotes	/
T6643	21958-21960	CC	denotes	or
T6644	21961-21964	DT	denotes	the
T6645	21986-21993	NNS	denotes	signals
T6646	21965-21972	JJ	denotes	nuclear
T6647	21973-21985	NN	denotes	localization
T6648	21994-21997	CC	denotes	and
T6649	21998-22005	NN	denotes	binding
T6650	22006-22010	NN	denotes	site
T6651	22011-22014	IN	denotes	for
T6652	22015-22020	NN	denotes	GAS41
T6653	22021-22022	-LRB-	denotes	[
T6654	22022-22024	CD	denotes	15
T6655	22024-22025	-RRB-	denotes	]
T6656	22026-22029	CC	denotes	and
T6657	22030-22040	NN	denotes	PCTAIRE2BP
T6658	22041-22042	-LRB-	denotes	[
T6659	22042-22044	CD	denotes	20
T6660	22044-22045	-RRB-	denotes	]
T6661	22046-22047	-LRB-	denotes	(
T6662	22056-22057	NN	denotes	B
T6663	22047-22055	NNS	denotes	isoforms
T6664	22057-22058	SYM	denotes	-
T6665	22058-22059	NN	denotes	D
T6666	22059-22061	,	denotes	,
T6667	22061-22062	NN	denotes	S
T6668	22062-22063	-RRB-	denotes	)
T6669	22063-22064	.	denotes	.
T6670	22064-22298	sentence	denotes	One of these isoforms, TACC1S is localized exclusively to the cytoplasm [19], suggesting that the shorter isoforms would not be able to interact with elements of the chomatin remodeling and/or RNA processing machinery in the nucleus.
T6671	22065-22068	CD	denotes	One
T6672	22098-22107	VBN	denotes	localized
T6673	22069-22071	IN	denotes	of
T6674	22072-22077	DT	denotes	these
T6675	22078-22086	NNS	denotes	isoforms
T6676	22086-22088	,	denotes	,
T6677	22088-22094	NN	denotes	TACC1S
T6678	22095-22097	VBZ	denotes	is
T6679	22108-22119	RB	denotes	exclusively
T6680	22120-22122	IN	denotes	to
T6681	22123-22126	DT	denotes	the
T6682	22127-22136	NN	denotes	cytoplasm
T6683	22137-22138	-LRB-	denotes	[
T6684	22138-22140	CD	denotes	19
T6685	22140-22141	-RRB-	denotes	]
T6686	22141-22143	,	denotes	,
T6687	22143-22153	VBG	denotes	suggesting
T6688	22154-22158	IN	denotes	that
T6689	22190-22192	VB	denotes	be
T6690	22159-22162	DT	denotes	the
T6691	22171-22179	NNS	denotes	isoforms
T6692	22163-22170	JJR	denotes	shorter
T6693	22180-22185	MD	denotes	would
T6694	22186-22189	RB	denotes	not
T6695	22193-22197	JJ	denotes	able
T6696	22198-22200	TO	denotes	to
T6697	22201-22209	VB	denotes	interact
T6698	22210-22214	IN	denotes	with
T6699	22215-22223	NNS	denotes	elements
T6700	22224-22226	IN	denotes	of
T6701	22227-22230	DT	denotes	the
T6702	22240-22250	NN	denotes	remodeling
T6703	22231-22239	NN	denotes	chomatin
T6704	22251-22254	CC	denotes	and
T6705	22254-22255	HYPH	denotes	/
T6706	22255-22257	CC	denotes	or
T6707	22258-22261	NN	denotes	RNA
T6708	22273-22282	NN	denotes	machinery
T6709	22262-22272	NN	denotes	processing
T6710	22283-22285	IN	denotes	in
T6711	22286-22289	DT	denotes	the
T6712	22290-22297	NN	denotes	nucleus
T6713	22297-22298	.	denotes	.
T6714	22298-22565	sentence	denotes	Thus, changes in the complement of TACC1 isoforms in the cell may result in alterations in cellular RNA metabolism at multiple levels, and may account for the observation that TACC1D and TACC1F isoforms are associated with tumorigenic changes in gastric mucosa [18].
T6715	22299-22303	RB	denotes	Thus
T6716	22365-22371	VB	denotes	result
T6717	22303-22305	,	denotes	,
T6718	22305-22312	NNS	denotes	changes
T6719	22313-22315	IN	denotes	in
T6720	22316-22319	DT	denotes	the
T6721	22320-22330	NN	denotes	complement
T6722	22331-22333	IN	denotes	of
T6723	22334-22339	NN	denotes	TACC1
T6724	22340-22348	NNS	denotes	isoforms
T6725	22349-22351	IN	denotes	in
T6726	22352-22355	DT	denotes	the
T6727	22356-22360	NN	denotes	cell
T6728	22361-22364	MD	denotes	may
T6729	22372-22374	IN	denotes	in
T6730	22375-22386	NNS	denotes	alterations
T6731	22387-22389	IN	denotes	in
T6732	22390-22398	JJ	denotes	cellular
T6733	22403-22413	NN	denotes	metabolism
T6734	22399-22402	NN	denotes	RNA
T6735	22414-22416	IN	denotes	at
T6736	22417-22425	JJ	denotes	multiple
T6737	22426-22432	NNS	denotes	levels
T6738	22432-22434	,	denotes	,
T6739	22434-22437	CC	denotes	and
T6740	22438-22441	MD	denotes	may
T6741	22442-22449	VB	denotes	account
T6742	22450-22453	IN	denotes	for
T6743	22454-22457	DT	denotes	the
T6744	22458-22469	NN	denotes	observation
T6745	22470-22474	IN	denotes	that
T6746	22506-22516	VBN	denotes	associated
T6747	22475-22481	NN	denotes	TACC1D
T6748	22493-22501	NNS	denotes	isoforms
T6749	22482-22485	CC	denotes	and
T6750	22486-22492	NN	denotes	TACC1F
T6751	22502-22505	VBP	denotes	are
T6752	22517-22521	IN	denotes	with
T6753	22522-22533	JJ	denotes	tumorigenic
T6754	22534-22541	NNS	denotes	changes
T6755	22542-22544	IN	denotes	in
T6756	22545-22552	JJ	denotes	gastric
T6757	22553-22559	NN	denotes	mucosa
T6758	22560-22561	-LRB-	denotes	[
T6759	22561-22563	CD	denotes	18
T6760	22563-22564	-RRB-	denotes	]
T6761	22564-22565	.	denotes	.
T13815	27929-28013	sentence	denotes	In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family.
T7167	23768-23770	FW	denotes	In
T7168	23771-23777	FW	denotes	silico
T7169	23778-23786	NN	denotes	modeling
T7170	23787-23789	IN	denotes	of
T7171	23790-23793	DT	denotes	the
T7172	23794-23803	NN	denotes	evolution
T7173	23804-23806	IN	denotes	of
T7174	23807-23811	NN	denotes	TACC
T7175	23812-23819	NN	denotes	protein
T7176	23820-23828	NN	denotes	function
T7177	23828-24033	sentence	denotes	The protein and genomic structure of the present day TACC family members suggests that the function of the ancestral TACC protein was mediated solely through the interactions of the conserved TACC domain.
T7178	23829-23832	DT	denotes	The
T7179	23853-23862	NN	denotes	structure
T7180	23833-23840	NN	denotes	protein
T7181	23841-23844	CC	denotes	and
T7182	23845-23852	JJ	denotes	genomic
T7183	23902-23910	VBZ	denotes	suggests
T7184	23863-23865	IN	denotes	of
T7185	23866-23869	DT	denotes	the
T7186	23894-23901	NNS	denotes	members
T7187	23870-23877	JJ	denotes	present
T7188	23878-23881	NN	denotes	day
T7189	23882-23886	NN	denotes	TACC
T7190	23887-23893	NN	denotes	family
T7191	23911-23915	IN	denotes	that
T7192	23963-23971	VBN	denotes	mediated
T7193	23916-23919	DT	denotes	the
T7194	23920-23928	NN	denotes	function
T7195	23929-23931	IN	denotes	of
T7196	23932-23935	DT	denotes	the
T7197	23951-23958	NN	denotes	protein
T7198	23936-23945	JJ	denotes	ancestral
T7199	23946-23950	NN	denotes	TACC
T7200	23959-23962	VBD	denotes	was
T7201	23972-23978	RB	denotes	solely
T7202	23979-23986	IN	denotes	through
T7203	23987-23990	DT	denotes	the
T7204	23991-24003	NNS	denotes	interactions
T7205	24004-24006	IN	denotes	of
T7206	24007-24010	DT	denotes	the
T7207	24026-24032	NN	denotes	domain
T7208	24011-24020	VBN	denotes	conserved
T7209	24021-24025	NN	denotes	TACC
T7210	24032-24033	.	denotes	.
T7211	24033-24332	sentence	denotes	Using an in silico protein-protein interaction model based upon known mitotic spindle and centrosomal components, we have previously predicted a number of additional interactions that could be conserved between a functional TACC homologue in yeast, spc-72, and one or more human TACC proteins [21].
T7212	24034-24039	VBG	denotes	Using
T7213	24167-24176	VBN	denotes	predicted
T7214	24040-24042	DT	denotes	an
T7215	24081-24086	NN	denotes	model
T7216	24043-24045	FW	denotes	in
T7217	24046-24052	FW	denotes	silico
T7218	24053-24060	NN	denotes	protein
T7219	24061-24068	NN	denotes	protein
T7220	24060-24061	HYPH	denotes	-
T7221	24069-24080	NN	denotes	interaction
T7222	24087-24092	VBN	denotes	based
T7223	24093-24097	IN	denotes	upon
T7224	24098-24103	JJ	denotes	known
T7225	24136-24146	NNS	denotes	components
T7226	24104-24111	JJ	denotes	mitotic
T7227	24112-24119	NN	denotes	spindle
T7228	24120-24123	CC	denotes	and
T7229	24124-24135	JJ	denotes	centrosomal
T7230	24146-24148	,	denotes	,
T7231	24148-24150	PRP	denotes	we
T7232	24151-24155	VBP	denotes	have
T7233	24156-24166	RB	denotes	previously
T7234	24177-24178	DT	denotes	a
T7235	24179-24185	NN	denotes	number
T7236	24186-24188	IN	denotes	of
T7237	24189-24199	JJ	denotes	additional
T7238	24200-24212	NNS	denotes	interactions
T7239	24213-24217	WDT	denotes	that
T7240	24227-24236	VBN	denotes	conserved
T7241	24218-24223	MD	denotes	could
T7242	24224-24226	VB	denotes	be
T7243	24237-24244	IN	denotes	between
T7244	24245-24246	DT	denotes	a
T7245	24263-24272	NN	denotes	homologue
T7246	24247-24257	JJ	denotes	functional
T7247	24258-24262	NN	denotes	TACC
T7248	24273-24275	IN	denotes	in
T7249	24276-24281	NN	denotes	yeast
T7250	24281-24283	,	denotes	,
T7251	24283-24286	NN	denotes	spc
T7252	24286-24287	HYPH	denotes	-
T7253	24287-24289	CD	denotes	72
T7254	24289-24291	,	denotes	,
T7255	24291-24294	CC	denotes	and
T7256	24295-24298	CD	denotes	one
T7257	24318-24326	NN	denotes	proteins
T7258	24299-24301	CC	denotes	or
T7259	24302-24306	JJR	denotes	more
T7260	24307-24312	JJ	denotes	human
T7261	24313-24317	NN	denotes	TACC
T7262	24327-24328	-LRB-	denotes	[
T7263	24328-24330	CD	denotes	21
T7264	24330-24331	-RRB-	denotes	]
T7265	24331-24332	.	denotes	.
T7266	24332-24551	sentence	denotes	Thus, it is known that all the TACC proteins examined to date interact, via the TACC domain, with the microtubule/centrosomal proteins of the stu2/msps/ch-TOG family [5,6,22-24], and with the Aurora kinases [20,21,25].
T7267	24333-24337	RB	denotes	Thus
T7268	24345-24350	VBN	denotes	known
T7269	24337-24339	,	denotes	,
T7270	24339-24341	PRP	denotes	it
T7271	24342-24344	VBZ	denotes	is
T7272	24351-24355	IN	denotes	that
T7273	24395-24403	VBP	denotes	interact
T7274	24356-24359	PDT	denotes	all
T7275	24369-24377	NN	denotes	proteins
T7276	24360-24363	DT	denotes	the
T7277	24364-24368	NN	denotes	TACC
T7278	24378-24386	VBN	denotes	examined
T7279	24387-24389	IN	denotes	to
T7280	24390-24394	NN	denotes	date
T7281	24403-24405	,	denotes	,
T7282	24405-24408	IN	denotes	via
T7283	24409-24412	DT	denotes	the
T7284	24418-24424	NN	denotes	domain
T7285	24413-24417	NN	denotes	TACC
T7286	24424-24426	,	denotes	,
T7287	24426-24430	IN	denotes	with
T7288	24431-24434	DT	denotes	the
T7289	24459-24467	NN	denotes	proteins
T7290	24435-24446	NN	denotes	microtubule
T7291	24447-24458	JJ	denotes	centrosomal
T7292	24446-24447	HYPH	denotes	/
T7293	24468-24470	IN	denotes	of
T7294	24471-24474	DT	denotes	the
T7295	24492-24498	NN	denotes	family
T7296	24475-24479	NN	denotes	stu2
T7297	24479-24480	HYPH	denotes	/
T7298	24480-24484	NN	denotes	msps
T7299	24484-24485	HYPH	denotes	/
T7300	24485-24487	NN	denotes	ch
T7301	24488-24491	NN	denotes	TOG
T7302	24487-24488	HYPH	denotes	-
T7303	24499-24500	-LRB-	denotes	[
T7304	24500-24501	CD	denotes	5
T7305	24501-24502	,	denotes	,
T7306	24502-24503	CD	denotes	6
T7307	24503-24504	,	denotes	,
T7308	24504-24506	CD	denotes	22
T7309	24506-24507	SYM	denotes	-
T7310	24507-24509	CD	denotes	24
T7311	24509-24510	-RRB-	denotes	]
T7312	24510-24512	,	denotes	,
T7313	24512-24515	CC	denotes	and
T7314	24516-24520	IN	denotes	with
T7315	24521-24524	DT	denotes	the
T7316	24532-24539	NNS	denotes	kinases
T7317	24525-24531	NN	denotes	Aurora
T7318	24540-24541	-LRB-	denotes	[
T7319	24547-24549	CD	denotes	25
T7320	24541-24543	CD	denotes	20
T7321	24543-24544	,	denotes	,
T7322	24544-24546	CD	denotes	21
T7323	24546-24547	,	denotes	,
T7324	24549-24550	-RRB-	denotes	]
T7325	24550-24551	.	denotes	.
T7326	24551-24683	sentence	denotes	These interactions are required for the accumulation of the D-TACC, spc72, ceTAC1 and TACC3 proteins to the centrosome [5,6,22-24].
T7327	24552-24557	DT	denotes	These
T7328	24558-24570	NNS	denotes	interactions
T7329	24575-24583	VBN	denotes	required
T7330	24571-24574	VBP	denotes	are
T7331	24584-24587	IN	denotes	for
T7332	24588-24591	DT	denotes	the
T7333	24592-24604	NN	denotes	accumulation
T7334	24605-24607	IN	denotes	of
T7335	24608-24611	DT	denotes	the
T7336	24644-24652	NN	denotes	proteins
T7337	24612-24613	NN	denotes	D
T7338	24614-24618	NN	denotes	TACC
T7339	24613-24614	HYPH	denotes	-
T7340	24618-24620	,	denotes	,
T7341	24620-24625	NN	denotes	spc72
T7342	24625-24627	,	denotes	,
T7343	24627-24633	NN	denotes	ceTAC1
T7344	24634-24637	CC	denotes	and
T7345	24638-24643	NN	denotes	TACC3
T7346	24653-24655	IN	denotes	to
T7347	24656-24659	DT	denotes	the
T7348	24660-24670	NN	denotes	centrosome
T7349	24671-24672	-LRB-	denotes	[
T7350	24672-24673	CD	denotes	5
T7351	24673-24674	,	denotes	,
T7352	24674-24675	CD	denotes	6
T7353	24675-24676	,	denotes	,
T7354	24676-24678	CD	denotes	22
T7355	24678-24679	SYM	denotes	-
T7356	24679-24681	CD	denotes	24
T7357	24681-24682	-RRB-	denotes	]
T7358	24682-24683	.	denotes	.
T7359	24683-24833	sentence	denotes	Hence, this functional interaction with the centrosome and mitotic spindle is likely to represent the ancient, conserved function of the TACC family.
T7360	24684-24689	RB	denotes	Hence
T7361	24759-24761	VBZ	denotes	is
T7362	24689-24691	,	denotes	,
T7363	24691-24695	DT	denotes	this
T7364	24707-24718	NN	denotes	interaction
T7365	24696-24706	JJ	denotes	functional
T7366	24719-24723	IN	denotes	with
T7367	24724-24727	DT	denotes	the
T7368	24728-24738	NN	denotes	centrosome
T7369	24739-24742	CC	denotes	and
T7370	24743-24750	JJ	denotes	mitotic
T7371	24751-24758	NN	denotes	spindle
T7372	24762-24768	JJ	denotes	likely
T7373	24769-24771	TO	denotes	to
T7374	24772-24781	VB	denotes	represent
T7375	24782-24785	DT	denotes	the
T7376	24805-24813	NN	denotes	function
T7377	24786-24793	JJ	denotes	ancient
T7378	24793-24795	,	denotes	,
T7379	24795-24804	VBN	denotes	conserved
T7380	24814-24816	IN	denotes	of
T7381	24817-24820	DT	denotes	the
T7382	24826-24832	NN	denotes	family
T7383	24821-24825	NN	denotes	TACC
T7384	24832-24833	.	denotes	.
T7385	24833-24952	sentence	denotes	However, it is apparent that the human TACC proteins also differ in their ability to interact with the Aurora kinases.
T7386	24834-24841	RB	denotes	However
T7387	24846-24848	VBZ	denotes	is
T7388	24841-24843	,	denotes	,
T7389	24843-24845	PRP	denotes	it
T7390	24849-24857	JJ	denotes	apparent
T7391	24858-24862	IN	denotes	that
T7392	24892-24898	VBP	denotes	differ
T7393	24863-24866	DT	denotes	the
T7394	24878-24886	NN	denotes	proteins
T7395	24867-24872	JJ	denotes	human
T7396	24873-24877	NN	denotes	TACC
T7397	24887-24891	RB	denotes	also
T7398	24899-24901	IN	denotes	in
T7399	24902-24907	PRP$	denotes	their
T7400	24908-24915	NN	denotes	ability
T7401	24916-24918	TO	denotes	to
T7402	24919-24927	VB	denotes	interact
T7403	24928-24932	IN	denotes	with
T7404	24933-24936	DT	denotes	the
T7405	24944-24951	NNS	denotes	kinases
T7406	24937-24943	NN	denotes	Aurora
T7407	24951-24952	.	denotes	.
T7408	24952-25214	sentence	denotes	For instance, TACC1 and TACC3 interact with Aurora A kinase, whereas TACC2 interacts with Aurora C kinase [21], suggesting a degree of functional specialization in the derivatives of the ancestral chordate TACC, after the radiation of the vertebrate TACC genes.
T7409	24953-24956	IN	denotes	For
T7410	24983-24991	VBP	denotes	interact
T7411	24957-24965	NN	denotes	instance
T7412	24965-24967	,	denotes	,
T7413	24967-24972	NN	denotes	TACC1
T7414	24973-24976	CC	denotes	and
T7415	24977-24982	NN	denotes	TACC3
T7416	24992-24996	IN	denotes	with
T7417	24997-25003	NN	denotes	Aurora
T7418	25004-25005	NN	denotes	A
T7419	25006-25012	NN	denotes	kinase
T7420	25012-25014	,	denotes	,
T7421	25014-25021	IN	denotes	whereas
T7422	25028-25037	VBZ	denotes	interacts
T7423	25022-25027	NN	denotes	TACC2
T7424	25038-25042	IN	denotes	with
T7425	25043-25049	NN	denotes	Aurora
T7426	25050-25051	NN	denotes	C
T7427	25052-25058	NN	denotes	kinase
T7428	25059-25060	-LRB-	denotes	[
T7429	25060-25062	CD	denotes	21
T7430	25062-25063	-RRB-	denotes	]
T7431	25063-25065	,	denotes	,
T7432	25065-25075	VBG	denotes	suggesting
T7433	25076-25077	DT	denotes	a
T7434	25078-25084	NN	denotes	degree
T7435	25085-25087	IN	denotes	of
T7436	25088-25098	JJ	denotes	functional
T7437	25099-25113	NN	denotes	specialization
T7438	25114-25116	IN	denotes	in
T7439	25117-25120	DT	denotes	the
T7440	25121-25132	NNS	denotes	derivatives
T7441	25133-25135	IN	denotes	of
T7442	25136-25139	DT	denotes	the
T7443	25159-25163	NN	denotes	TACC
T7444	25140-25149	JJ	denotes	ancestral
T7445	25150-25158	NN	denotes	chordate
T7446	25163-25165	,	denotes	,
T7447	25165-25170	IN	denotes	after
T7448	25171-25174	DT	denotes	the
T7449	25175-25184	NN	denotes	radiation
T7450	25185-25187	IN	denotes	of
T7451	25188-25191	DT	denotes	the
T7452	25208-25213	NNS	denotes	genes
T7453	25192-25202	NN	denotes	vertebrate
T7454	25203-25207	NN	denotes	TACC
T7455	25213-25214	.	denotes	.
T7456	25214-25416	sentence	denotes	The localization of the vertebrate TACC proteins in the interphase nucleus [15,26,27] suggests that they have additional functions outside their ancient role in the centrosome and microtubule dynamics.
T7457	25215-25218	DT	denotes	The
T7458	25219-25231	NN	denotes	localization
T7459	25301-25309	VBZ	denotes	suggests
T7460	25232-25234	IN	denotes	of
T7461	25235-25238	DT	denotes	the
T7462	25255-25263	NN	denotes	proteins
T7463	25239-25249	NN	denotes	vertebrate
T7464	25250-25254	NN	denotes	TACC
T7465	25264-25266	IN	denotes	in
T7466	25267-25270	DT	denotes	the
T7467	25282-25289	NN	denotes	nucleus
T7468	25271-25281	NN	denotes	interphase
T7469	25290-25291	-LRB-	denotes	[
T7470	25297-25299	CD	denotes	27
T7471	25291-25293	CD	denotes	15
T7472	25293-25294	,	denotes	,
T7473	25294-25296	CD	denotes	26
T7474	25296-25297	,	denotes	,
T7475	25299-25300	-RRB-	denotes	]
T7476	25310-25314	IN	denotes	that
T7477	25320-25324	VBP	denotes	have
T7478	25315-25319	PRP	denotes	they
T7479	25325-25335	JJ	denotes	additional
T7480	25336-25345	NNS	denotes	functions
T7481	25346-25353	IN	denotes	outside
T7482	25354-25359	PRP$	denotes	their
T7483	25368-25372	NN	denotes	role
T7484	25360-25367	JJ	denotes	ancient
T7485	25373-25375	IN	denotes	in
T7486	25376-25379	DT	denotes	the
T7487	25407-25415	NNS	denotes	dynamics
T7488	25380-25390	NN	denotes	centrosome
T7489	25391-25394	CC	denotes	and
T7490	25395-25406	NN	denotes	microtubule
T7491	25415-25416	.	denotes	.
T7492	25416-25587	sentence	denotes	Thus, it seems likely that TACC family members in protostomes and deuterostomes have integrated new unique functions as the evolving TACC genes acquired additional exons.
T7493	25417-25421	RB	denotes	Thus
T7494	25426-25431	VBZ	denotes	seems
T7495	25421-25423	,	denotes	,
T7496	25423-25425	PRP	denotes	it
T7497	25432-25438	JJ	denotes	likely
T7498	25439-25443	IN	denotes	that
T7499	25502-25512	VBN	denotes	integrated
T7500	25444-25448	NN	denotes	TACC
T7501	25456-25463	NNS	denotes	members
T7502	25449-25455	NN	denotes	family
T7503	25464-25466	IN	denotes	in
T7504	25467-25478	NNS	denotes	protostomes
T7505	25479-25482	CC	denotes	and
T7506	25483-25496	NNS	denotes	deuterostomes
T7507	25497-25501	VBP	denotes	have
T7508	25513-25516	JJ	denotes	new
T7509	25524-25533	NNS	denotes	functions
T7510	25517-25523	JJ	denotes	unique
T7511	25534-25536	IN	denotes	as
T7512	25561-25569	VBD	denotes	acquired
T7513	25537-25540	DT	denotes	the
T7514	25555-25560	NNS	denotes	genes
T7515	25541-25549	VBG	denotes	evolving
T7516	25550-25554	NN	denotes	TACC
T7517	25570-25580	JJ	denotes	additional
T7518	25581-25586	NNS	denotes	exons
T7519	25586-25587	.	denotes	.
T7520	25587-25743	sentence	denotes	The results of the pilot large-scale proteomic analysis in C. elegans and D. melanogaster provide further suggestive evidence to this functional evolution.
T7521	25588-25591	DT	denotes	The
T7522	25592-25599	NNS	denotes	results
T7523	25678-25685	VBP	denotes	provide
T7524	25600-25602	IN	denotes	of
T7525	25603-25606	DT	denotes	the
T7526	25635-25643	NN	denotes	analysis
T7527	25607-25612	NN	denotes	pilot
T7528	25613-25618	JJ	denotes	large
T7529	25619-25624	NN	denotes	scale
T7530	25618-25619	HYPH	denotes	-
T7531	25625-25634	JJ	denotes	proteomic
T7532	25644-25646	IN	denotes	in
T7533	25647-25649	NNP	denotes	C.
T7534	25650-25657	NNP	denotes	elegans
T7535	25658-25661	CC	denotes	and
T7536	25662-25664	NNP	denotes	D.
T7537	25665-25677	NNP	denotes	melanogaster
T7538	25686-25693	JJ	denotes	further
T7539	25705-25713	NN	denotes	evidence
T7540	25694-25704	JJ	denotes	suggestive
T7541	25714-25716	IN	denotes	to
T7542	25717-25721	DT	denotes	this
T7543	25733-25742	NN	denotes	evolution
T7544	25722-25732	JJ	denotes	functional
T7545	25742-25743	.	denotes	.
T7546	25743-25849	sentence	denotes	Yeast two hybrid analysis indicates that ceTAC directly binds to C. elegans lin15A, lin36 and lin37 [28].
T7547	25744-25749	NN	denotes	Yeast
T7548	25761-25769	NN	denotes	analysis
T7549	25750-25753	CD	denotes	two
T7550	25754-25760	NN	denotes	hybrid
T7551	25770-25779	VBZ	denotes	indicates
T7552	25780-25784	IN	denotes	that
T7553	25800-25805	VBZ	denotes	binds
T7554	25785-25790	NN	denotes	ceTAC
T7555	25791-25799	RB	denotes	directly
T7556	25806-25808	IN	denotes	to
T7557	25809-25811	NNP	denotes	C.
T7558	25820-25826	NN	denotes	lin15A
T7559	25812-25819	NNP	denotes	elegans
T7560	25826-25828	,	denotes	,
T7561	25828-25833	NN	denotes	lin36
T7562	25834-25837	CC	denotes	and
T7563	25838-25843	NN	denotes	lin37
T7564	25844-25845	-LRB-	denotes	[
T7565	25845-25847	CD	denotes	28
T7566	25847-25848	-RRB-	denotes	]
T7567	25848-25849	.	denotes	.
T7568	25849-26232	sentence	denotes	These proteins bridge ceTAC to other elements of the cytoskeleton and microtubule network, as well as to components of the ribosome, the histone deacetylase chromatin remodeling machinery such as egr-1 and lin-53 (the C. elegans homologues of the human MTA-1 and RbAP48), and to transcription factors such as the PAL1 homeobox and the nuclear hormone receptor nhr-86 [28] (Fig. 6A).
T7569	25850-25855	DT	denotes	These
T7570	25856-25864	NN	denotes	proteins
T7571	25865-25871	VBP	denotes	bridge
T7572	25872-25877	NN	denotes	ceTAC
T7573	25878-25880	IN	denotes	to
T7574	25881-25886	JJ	denotes	other
T7575	25887-25895	NNS	denotes	elements
T7576	25896-25898	IN	denotes	of
T7577	25899-25902	DT	denotes	the
T7578	25932-25939	NN	denotes	network
T7579	25903-25915	NN	denotes	cytoskeleton
T7580	25916-25919	CC	denotes	and
T7581	25920-25931	NN	denotes	microtubule
T7582	25939-25941	,	denotes	,
T7583	25941-25943	RB	denotes	as
T7584	25949-25951	IN	denotes	as
T7585	25944-25948	RB	denotes	well
T7586	25952-25954	IN	denotes	to
T7587	25955-25965	NNS	denotes	components
T7588	25966-25968	IN	denotes	of
T7589	25969-25972	DT	denotes	the
T7590	25973-25981	NN	denotes	ribosome
T7591	25981-25983	,	denotes	,
T7592	25983-25986	DT	denotes	the
T7593	26028-26037	NN	denotes	machinery
T7594	25987-25994	NN	denotes	histone
T7595	25995-26006	NN	denotes	deacetylase
T7596	26007-26016	NN	denotes	chromatin
T7597	26017-26027	VBG	denotes	remodeling
T7598	26038-26042	JJ	denotes	such
T7599	26043-26045	IN	denotes	as
T7600	26046-26049	NN	denotes	egr
T7601	26049-26050	HYPH	denotes	-
T7602	26050-26051	CD	denotes	1
T7603	26052-26055	CC	denotes	and
T7604	26056-26059	NN	denotes	lin
T7605	26059-26060	HYPH	denotes	-
T7606	26060-26062	CD	denotes	53
T7607	26063-26064	-LRB-	denotes	(
T7608	26064-26067	DT	denotes	the
T7609	26079-26089	NNS	denotes	homologues
T7610	26068-26070	NNP	denotes	C.
T7611	26071-26078	NNP	denotes	elegans
T7612	26090-26092	IN	denotes	of
T7613	26093-26096	DT	denotes	the
T7614	26103-26106	NN	denotes	MTA
T7615	26097-26102	JJ	denotes	human
T7616	26106-26107	HYPH	denotes	-
T7617	26107-26108	CD	denotes	1
T7618	26109-26112	CC	denotes	and
T7619	26113-26119	NN	denotes	RbAP48
T7620	26119-26120	-RRB-	denotes	)
T7621	26120-26122	,	denotes	,
T7622	26122-26125	CC	denotes	and
T7623	26126-26128	IN	denotes	to
T7624	26129-26142	NN	denotes	transcription
T7625	26143-26150	NNS	denotes	factors
T7626	26151-26155	JJ	denotes	such
T7627	26156-26158	IN	denotes	as
T7628	26159-26162	DT	denotes	the
T7629	26168-26176	NN	denotes	homeobox
T7630	26163-26167	NN	denotes	PAL1
T7631	26177-26180	CC	denotes	and
T7632	26181-26184	DT	denotes	the
T7633	26201-26209	NN	denotes	receptor
T7634	26185-26192	JJ	denotes	nuclear
T7635	26193-26200	NN	denotes	hormone
T7636	26210-26213	NN	denotes	nhr
T7637	26213-26214	HYPH	denotes	-
T7638	26214-26216	CD	denotes	86
T7639	26217-26218	-LRB-	denotes	[
T7640	26218-26220	CD	denotes	28
T7641	26220-26221	-RRB-	denotes	]
T7642	26222-26223	-LRB-	denotes	(
T7643	26223-26227	NN	denotes	Fig.
T7644	26228-26230	CD	denotes	6A
T7645	26230-26231	-RRB-	denotes	)
T7646	26231-26232	.	denotes	.
T7647	26232-26493	sentence	denotes	Similarly, large scale proteomics [29] has shown that Drosophila TACC interacts with two proteins, the RNA binding protein TBPH and CG14540 (Fig. 6B), and thus indirectly with the Drosophila SWI/SNF chromatin remodeling complex and DNA damage repair machinery.
T7648	26233-26242	RB	denotes	Similarly
T7649	26276-26281	VBN	denotes	shown
T7650	26242-26244	,	denotes	,
T7651	26244-26249	JJ	denotes	large
T7652	26250-26255	NN	denotes	scale
T7653	26256-26266	NNS	denotes	proteomics
T7654	26267-26268	-LRB-	denotes	[
T7655	26268-26270	CD	denotes	29
T7656	26270-26271	-RRB-	denotes	]
T7657	26272-26275	VBZ	denotes	has
T7658	26282-26286	IN	denotes	that
T7659	26303-26312	VBZ	denotes	interacts
T7660	26287-26297	NNP	denotes	Drosophila
T7661	26298-26302	NN	denotes	TACC
T7662	26313-26317	IN	denotes	with
T7663	26318-26321	CD	denotes	two
T7664	26322-26330	NN	denotes	proteins
T7665	26330-26332	,	denotes	,
T7666	26332-26335	DT	denotes	the
T7667	26348-26355	NN	denotes	protein
T7668	26336-26339	NN	denotes	RNA
T7669	26340-26347	NN	denotes	binding
T7670	26356-26360	NN	denotes	TBPH
T7671	26361-26364	CC	denotes	and
T7672	26365-26372	NN	denotes	CG14540
T7680	26404-26408	IN	denotes	with
T7681	26393-26403	RB	denotes	indirectly
T7682	26409-26412	DT	denotes	the
T7683	26453-26460	NN	denotes	complex
T7684	26413-26423	NNP	denotes	Drosophila
T7685	26424-26427	NN	denotes	SWI
T7686	26428-26431	NN	denotes	SNF
T7687	26427-26428	HYPH	denotes	/
T7688	26432-26441	NN	denotes	chromatin
T7689	26442-26452	NN	denotes	remodeling
T7690	26461-26464	CC	denotes	and
T7691	26465-26468	NN	denotes	DNA
T7692	26469-26475	NN	denotes	damage
T7693	26476-26482	NN	denotes	repair
T7694	26483-26492	NN	denotes	machinery
T7695	26492-26493	.	denotes	.
T7696	26493-26648	sentence	denotes	Significantly, the ceTAC protein has also recently been implicated in DNA repair through its direct interaction with the C. elegans BARD1 orthologue [30].
T7697	26494-26507	RB	denotes	Significantly
T7698	26550-26560	VBN	denotes	implicated
T7699	26507-26509	,	denotes	,
T7700	26509-26512	DT	denotes	the
T7701	26519-26526	NN	denotes	protein
T7702	26513-26518	NN	denotes	ceTAC
T7703	26527-26530	VBZ	denotes	has
T7704	26531-26535	RB	denotes	also
T7705	26536-26544	RB	denotes	recently
T7706	26545-26549	VBN	denotes	been
T7707	26561-26563	IN	denotes	in
T7708	26564-26567	NN	denotes	DNA
T7709	26568-26574	NN	denotes	repair
T7710	26575-26582	IN	denotes	through
T7711	26583-26586	PRP$	denotes	its
T7712	26594-26605	NN	denotes	interaction
T7713	26587-26593	JJ	denotes	direct
T7714	26606-26610	IN	denotes	with
T7715	26611-26614	DT	denotes	the
T7716	26632-26642	NN	denotes	orthologue
T7717	26615-26617	NNP	denotes	C.
T7718	26618-26625	NNP	denotes	elegans
T7719	26626-26631	NN	denotes	BARD1
T7720	26643-26644	-LRB-	denotes	[
T7721	26644-26646	CD	denotes	30
T7722	26646-26647	-RRB-	denotes	]
T7723	26647-26648	.	denotes	.
T7724	26648-26904	sentence	denotes	It should be noted that a number of interactions with the TACC proteins from these organisms have probably been missed by these large scale methods, including the well documented direct interactions with the aurora kinases and the stu2/msps/ch-TOG family.
T7725	26649-26651	PRP	denotes	It
T7726	26662-26667	VBN	denotes	noted
T7727	26652-26658	MD	denotes	should
T7728	26659-26661	VB	denotes	be
T7729	26668-26672	IN	denotes	that
T7730	26761-26767	VBN	denotes	missed
T7731	26673-26674	DT	denotes	a
T7732	26675-26681	NN	denotes	number
T7733	26682-26684	IN	denotes	of
T7734	26685-26697	NNS	denotes	interactions
T7735	26698-26702	IN	denotes	with
T7736	26703-26706	DT	denotes	the
T7737	26712-26720	NN	denotes	proteins
T7738	26707-26711	NN	denotes	TACC
T7739	26721-26725	IN	denotes	from
T7740	26726-26731	DT	denotes	these
T7741	26732-26741	NNS	denotes	organisms
T7742	26742-26746	VBP	denotes	have
T7743	26747-26755	RB	denotes	probably
T7744	26756-26760	VBN	denotes	been
T7745	26768-26770	IN	denotes	by
T7746	26771-26776	DT	denotes	these
T7747	26789-26796	NNS	denotes	methods
T7748	26777-26782	JJ	denotes	large
T7749	26783-26788	NN	denotes	scale
T7750	26796-26798	,	denotes	,
T7751	26798-26807	VBG	denotes	including
T7752	26808-26811	DT	denotes	the
T7753	26835-26847	NNS	denotes	interactions
T7754	26812-26816	RB	denotes	well
T7755	26817-26827	VBN	denotes	documented
T7756	26828-26834	JJ	denotes	direct
T7757	26848-26852	IN	denotes	with
T7758	26853-26856	DT	denotes	the
T7759	26864-26871	NNS	denotes	kinases
T7760	26857-26863	NN	denotes	aurora
T7761	26872-26875	CC	denotes	and
T7762	26876-26879	DT	denotes	the
T7763	26897-26903	NN	denotes	family
T7764	26880-26884	NN	denotes	stu2
T7765	26884-26885	HYPH	denotes	/
T7766	26885-26889	NN	denotes	msps
T7767	26889-26890	HYPH	denotes	/
T7768	26890-26892	NN	denotes	ch
T7769	26893-26896	NN	denotes	TOG
T7770	26892-26893	HYPH	denotes	-
T7771	26903-26904	.	denotes	.
T7780	28058-28061	DT	denotes	the
T7781	28067-28073	NN	denotes	domain
T7782	28062-28066	NN	denotes	TACC
T7783	28073-28075	,	denotes	,
T7784	28075-28077	PRP	denotes	we
T7785	28078-28083	MD	denotes	would
T7786	28092-28096	IN	denotes	that
T7787	28181-28189	VBN	denotes	observed
T7788	28097-28101	DT	denotes	some
T7789	28102-28104	IN	denotes	of
T7790	28105-28108	DT	denotes	the
T7791	28120-28132	NNS	denotes	interactions
T7792	28109-28119	JJ	denotes	functional
T7793	28133-28137	VBN	denotes	seen
T7794	28138-28140	IN	denotes	in
T7795	28141-28143	NNP	denotes	C.
T7796	28144-28151	NNP	denotes	elegans
T7797	28152-28155	CC	denotes	and
T7798	28156-28158	NNP	denotes	D.
T7799	28159-28171	NNP	denotes	melanogaster
T7800	28172-28177	MD	denotes	would
T7801	28178-28180	VB	denotes	be
T7802	28190-28192	IN	denotes	in
T7803	28193-28199	JJR	denotes	higher
T7804	28200-28207	NNS	denotes	animals
T7805	28207-28208	.	denotes	.
T7806	28208-28350	sentence	denotes	Phylogenetic profiling from these interaction maps suggests two similar sets of predicted interactions for vertebrate TACCs (Fig. 6C and 6D).
T7807	28209-28221	JJ	denotes	Phylogenetic
T7808	28222-28231	NN	denotes	profiling
T7809	28260-28268	VBZ	denotes	suggests
T7810	28232-28236	IN	denotes	from
T7811	28237-28242	DT	denotes	these
T7812	28255-28259	NNS	denotes	maps
T7813	28243-28254	NN	denotes	interaction
T7814	28269-28272	CD	denotes	two
T7815	28281-28285	NNS	denotes	sets
T7816	28273-28280	JJ	denotes	similar
T7817	28286-28288	IN	denotes	of
T7818	28289-28298	VBN	denotes	predicted
T7819	28299-28311	NNS	denotes	interactions
T7820	28312-28315	IN	denotes	for
T7821	28316-28326	NN	denotes	vertebrate
T7822	28327-28332	NNS	denotes	TACCs
T7823	28333-28334	-LRB-	denotes	(
T7824	28339-28341	CD	denotes	6C
T7825	28334-28338	NN	denotes	Fig.
T7826	28342-28345	CC	denotes	and
T7827	28346-28348	CD	denotes	6D
T7828	28348-28349	-RRB-	denotes	)
T7829	28349-28350	.	denotes	.
T7830	28350-28687	sentence	denotes	Strikingly, however, the C. elegans specific proteins lin15A, lin36 and lin37 do not have readily discernible homologues in vertebrates or Drosophila, although the presence of a zinc finger domain in lin36 may suggest that this protein is involved directly in transcription or perform an adaptor role similar to LIM containing proteins.
T7831	28351-28361	RB	denotes	Strikingly
T7832	28436-28440	VB	denotes	have
T7833	28361-28363	,	denotes	,
T7834	28363-28370	RB	denotes	however
T7835	28370-28372	,	denotes	,
T7836	28372-28375	DT	denotes	the
T7837	28396-28404	NN	denotes	proteins
T7838	28376-28378	NNP	denotes	C.
T7839	28379-28386	NNP	denotes	elegans
T7840	28387-28395	JJ	denotes	specific
T7841	28405-28411	NN	denotes	lin15A
T7842	28411-28413	,	denotes	,
T7843	28413-28418	NN	denotes	lin36
T7844	28419-28422	CC	denotes	and
T7845	28423-28428	NN	denotes	lin37
T7846	28429-28431	VBP	denotes	do
T7847	28432-28435	RB	denotes	not
T7848	28441-28448	RB	denotes	readily
T7849	28449-28460	JJ	denotes	discernible
T7850	28461-28471	NNS	denotes	homologues
T7851	28472-28474	IN	denotes	in
T7852	28475-28486	NNS	denotes	vertebrates
T7853	28487-28489	CC	denotes	or
T7854	28490-28500	NNP	denotes	Drosophila
T7855	28500-28502	,	denotes	,
T7856	28502-28510	IN	denotes	although
T7857	28561-28568	VB	denotes	suggest
T7858	28511-28514	DT	denotes	the
T7859	28515-28523	NN	denotes	presence
T7860	28524-28526	IN	denotes	of
T7861	28527-28528	DT	denotes	a
T7862	28541-28547	NN	denotes	domain
T7863	28529-28533	NN	denotes	zinc
T7864	28534-28540	NN	denotes	finger
T7865	28548-28550	IN	denotes	in
T7866	28551-28556	NN	denotes	lin36
T7867	28557-28560	MD	denotes	may
T7868	28569-28573	IN	denotes	that
T7869	28590-28598	VBN	denotes	involved
T7870	28574-28578	DT	denotes	this
T7871	28579-28586	NN	denotes	protein
T7872	28587-28589	VBZ	denotes	is
T7873	28599-28607	RB	denotes	directly
T7874	28608-28610	IN	denotes	in
T7875	28611-28624	NN	denotes	transcription
T7876	28625-28627	CC	denotes	or
T7877	28628-28635	VB	denotes	perform
T7878	28636-28638	DT	denotes	an
T7879	28647-28651	NN	denotes	role
T7880	28639-28646	NN	denotes	adaptor
T7881	28652-28659	JJ	denotes	similar
T7882	28660-28662	IN	denotes	to
T7883	28663-28666	NN	denotes	LIM
T7884	28667-28677	VBG	denotes	containing
T7885	28678-28686	NN	denotes	proteins
T7886	28686-28687	.	denotes	.
T7887	28687-28823	sentence	denotes	For the DTACC interacting proteins, TBPH corresponds to TDP43, a protein implicated in transcriptional regulation and splicing [31,32].
T7888	28688-28691	IN	denotes	For
T7889	28729-28740	VBZ	denotes	corresponds
T7890	28692-28695	DT	denotes	the
T7891	28714-28722	NN	denotes	proteins
T7892	28696-28701	NN	denotes	DTACC
T7893	28702-28713	VBG	denotes	interacting
T7894	28722-28724	,	denotes	,
T7895	28724-28728	NN	denotes	TBPH
T7896	28741-28743	IN	denotes	to
T7897	28744-28749	NN	denotes	TDP43
T7898	28749-28751	,	denotes	,
T7899	28751-28752	DT	denotes	a
T7900	28753-28760	NN	denotes	protein
T7901	28761-28771	VBN	denotes	implicated
T7902	28772-28774	IN	denotes	in
T7903	28775-28790	JJ	denotes	transcriptional
T7904	28791-28801	NN	denotes	regulation
T7905	28802-28805	CC	denotes	and
T7906	28806-28814	NN	denotes	splicing
T7907	28815-28816	-LRB-	denotes	[
T7908	28819-28821	CD	denotes	32
T7909	28816-28818	CD	denotes	31
T7910	28818-28819	,	denotes	,
T7911	28821-28822	-RRB-	denotes	]
T7912	28822-28823	.	denotes	.
T7913	28823-29041	sentence	denotes	However, the assignment of the human homologue of CG14540 is less clear, with the closest matches in the human databases corresponding to glutamine rich transcription factors such as CREB and the G-box binding factor.
T7914	28824-28831	RB	denotes	However
T7915	28882-28884	VBZ	denotes	is
T7916	28831-28833	,	denotes	,
T7917	28833-28836	DT	denotes	the
T7918	28837-28847	NN	denotes	assignment
T7919	28848-28850	IN	denotes	of
T7920	28851-28854	DT	denotes	the
T7921	28861-28870	NN	denotes	homologue
T7922	28855-28860	JJ	denotes	human
T7923	28871-28873	IN	denotes	of
T7924	28874-28881	NN	denotes	CG14540
T7925	28885-28889	RBR	denotes	less
T7926	28890-28895	JJ	denotes	clear
T7927	28895-28897	,	denotes	,
T7928	28897-28901	IN	denotes	with
T7929	28902-28905	DT	denotes	the
T7930	28914-28921	NNS	denotes	matches
T7931	28906-28913	JJS	denotes	closest
T7932	28945-28958	VBG	denotes	corresponding
T7933	28922-28924	IN	denotes	in
T7934	28925-28928	DT	denotes	the
T7935	28935-28944	NNS	denotes	databases
T7936	28929-28934	JJ	denotes	human
T7937	28959-28961	IN	denotes	to
T7938	28962-28971	NN	denotes	glutamine
T7939	28972-28976	JJ	denotes	rich
T7940	28991-28998	NNS	denotes	factors
T7941	28977-28990	NN	denotes	transcription
T7942	28999-29003	JJ	denotes	such
T7943	29004-29006	IN	denotes	as
T7944	29007-29011	NN	denotes	CREB
T7945	29012-29015	CC	denotes	and
T7946	29016-29019	DT	denotes	the
T7947	29034-29040	NN	denotes	factor
T7948	29020-29021	NN	denotes	G
T7949	29022-29025	NN	denotes	box
T7950	29021-29022	HYPH	denotes	-
T7951	29026-29033	NN	denotes	binding
T7952	29040-29041	.	denotes	.
T8332	29043-29053	NN	denotes	Comparison
T8333	29054-29056	IN	denotes	of
T8334	29057-29064	VBN	denotes	modeled
T8335	29065-29069	IN	denotes	with
T8336	29070-29084	RB	denotes	experimentally
T8337	29085-29092	VBN	denotes	defined
T8338	29093-29105	NNS	denotes	interactions
T8339	29106-29108	IN	denotes	of
T8340	29109-29112	DT	denotes	the
T8341	29129-29137	NN	denotes	proteins
T8342	29113-29123	NN	denotes	vertebrate
T8343	29124-29128	NN	denotes	TACC
T8344	29137-29265	sentence	denotes	The interaction data for the vertebrate TACCs is relatively limited; however, interaction networks are now beginning to emerge.
T8345	29138-29141	DT	denotes	The
T8346	29154-29158	NNS	denotes	data
T8347	29142-29153	NN	denotes	interaction
T8348	29184-29186	VBZ	denotes	is
T8349	29159-29162	IN	denotes	for
T8350	29163-29166	DT	denotes	the
T8351	29178-29183	NNS	denotes	TACCs
T8352	29167-29177	NN	denotes	vertebrate
T8353	29245-29254	VBG	denotes	beginning
T8354	29187-29197	RB	denotes	relatively
T8355	29198-29205	VBN	denotes	limited
T8356	29205-29206	:	denotes	;
T8357	29207-29214	RB	denotes	however
T8358	29214-29216	,	denotes	,
T8359	29216-29227	NN	denotes	interaction
T8360	29228-29236	NNS	denotes	networks
T8361	29237-29240	VBP	denotes	are
T8362	29241-29244	RB	denotes	now
T8363	29255-29257	TO	denotes	to
T8364	29258-29264	VB	denotes	emerge
T8365	29264-29265	.	denotes	.
T8366	29265-29451	sentence	denotes	The results of our functional analysis, as well as other published data clearly indicate that the vertebrate TACCs interact with proteins that can be divided into two broad categories:
T8367	29266-29269	DT	denotes	The
T8368	29270-29277	NNS	denotes	results
T8369	29346-29354	VBP	denotes	indicate
T8370	29278-29280	IN	denotes	of
T8371	29281-29284	PRP$	denotes	our
T8372	29296-29304	NN	denotes	analysis
T8373	29285-29295	JJ	denotes	functional
T8374	29304-29306	,	denotes	,
T8375	29306-29308	RB	denotes	as
T8376	29314-29316	IN	denotes	as
T8377	29309-29313	RB	denotes	well
T8378	29317-29322	JJ	denotes	other
T8379	29333-29337	NNS	denotes	data
T8380	29323-29332	VBN	denotes	published
T8381	29338-29345	RB	denotes	clearly
T8382	29355-29359	IN	denotes	that
T8383	29381-29389	VBP	denotes	interact
T8384	29360-29363	DT	denotes	the
T8385	29375-29380	NNS	denotes	TACCs
T8386	29364-29374	NN	denotes	vertebrate
T8387	29390-29394	IN	denotes	with
T8388	29395-29403	NN	denotes	proteins
T8389	29404-29408	WDT	denotes	that
T8390	29416-29423	VBN	denotes	divided
T8391	29409-29412	MD	denotes	can
T8392	29413-29415	VB	denotes	be
T8393	29424-29428	IN	denotes	into
T8394	29429-29432	CD	denotes	two
T8395	29439-29449	NNS	denotes	categories
T8396	29433-29438	JJ	denotes	broad
T8397	29449-29451	:	denotes	:
T8398	29451-29452	LS	denotes	1
T8399	29454-29462	NN	denotes	proteins
T8400	29451-29671	sentence	denotes	1) proteins with roles in centrosome/mitotic spindle dynamics, and 2) proteins involved in gene regulation, either at the level of transcription, or subsequent RNA processing and translation [3,5-7,15,19-21,24,25,33,34].
T8401	29452-29453	-RRB-	denotes	)
T8402	29463-29467	IN	denotes	with
T8403	29468-29473	NNS	denotes	roles
T8404	29474-29476	IN	denotes	in
T8405	29477-29487	NN	denotes	centrosome
T8406	29488-29495	JJ	denotes	mitotic
T8407	29487-29488	HYPH	denotes	/
T8408	29496-29503	NN	denotes	spindle
T8409	29504-29512	NNS	denotes	dynamics
T8410	29512-29514	,	denotes	,
T8411	29514-29517	CC	denotes	and
T8412	29518-29519	LS	denotes	2
T8413	29521-29529	NN	denotes	proteins
T8414	29519-29520	-RRB-	denotes	)
T8415	29530-29538	VBN	denotes	involved
T8416	29539-29541	IN	denotes	in
T8417	29542-29546	NN	denotes	gene
T8418	29547-29557	NN	denotes	regulation
T8419	29557-29559	,	denotes	,
T8420	29559-29565	CC	denotes	either
T8421	29566-29568	IN	denotes	at
T8422	29569-29572	DT	denotes	the
T8423	29573-29578	NN	denotes	level
T8424	29579-29581	IN	denotes	of
T8425	29582-29595	NN	denotes	transcription
T8426	29595-29597	,	denotes	,
T8427	29597-29599	CC	denotes	or
T8428	29600-29610	JJ	denotes	subsequent
T8429	29615-29625	NN	denotes	processing
T8430	29611-29614	NN	denotes	RNA
T8431	29626-29629	CC	denotes	and
T8432	29630-29641	NN	denotes	translation
T8433	29642-29643	-LRB-	denotes	[
T8434	29643-29644	CD	denotes	3
T8435	29644-29645	,	denotes	,
T8436	29645-29646	CD	denotes	5
T8437	29646-29647	SYM	denotes	-
T8438	29647-29648	CD	denotes	7
T8439	29648-29649	,	denotes	,
T8440	29649-29651	CD	denotes	15
T8441	29651-29652	,	denotes	,
T8442	29652-29654	CD	denotes	19
T8443	29654-29655	SYM	denotes	-
T8444	29655-29657	CD	denotes	21
T8445	29657-29658	,	denotes	,
T8446	29658-29660	CD	denotes	24
T8447	29660-29661	,	denotes	,
T8448	29661-29663	CD	denotes	25
T8449	29663-29664	,	denotes	,
T8450	29664-29666	CD	denotes	33
T8451	29666-29667	,	denotes	,
T8452	29667-29669	CD	denotes	34
T8453	29669-29670	-RRB-	denotes	]
T8454	29670-29671	.	denotes	.
T8455	29671-29826	sentence	denotes	Many of these proteins do not appear to interact directly with the protostome TACCs, but would be expected to be in the same protein complex (Fig. 6C,6D).
T8456	29672-29676	JJ	denotes	Many
T8457	29702-29708	VB	denotes	appear
T8458	29677-29679	IN	denotes	of
T8459	29680-29685	DT	denotes	these
T8460	29686-29694	NN	denotes	proteins
T8461	29695-29697	VBP	denotes	do
T8462	29698-29701	RB	denotes	not
T8463	29709-29711	TO	denotes	to
T8464	29712-29720	VB	denotes	interact
T8465	29721-29729	RB	denotes	directly
T8466	29730-29734	IN	denotes	with
T8467	29735-29738	DT	denotes	the
T8468	29750-29755	NNS	denotes	TACCs
T8469	29739-29749	NN	denotes	protostome
T8470	29755-29757	,	denotes	,
T8471	29757-29760	CC	denotes	but
T8472	29761-29766	MD	denotes	would
T8473	29770-29778	VBN	denotes	expected
T8474	29767-29769	VB	denotes	be
T8475	29779-29781	TO	denotes	to
T8476	29782-29784	VB	denotes	be
T8477	29785-29787	IN	denotes	in
T8478	29788-29791	DT	denotes	the
T8479	29805-29812	NN	denotes	complex
T8480	29792-29796	JJ	denotes	same
T8481	29797-29804	NN	denotes	protein
T8482	29813-29814	-LRB-	denotes	(
T8483	29822-29824	CD	denotes	6D
T8484	29814-29818	NN	denotes	Fig.
T8485	29819-29821	CD	denotes	6C
T8486	29821-29822	,	denotes	,
T8487	29824-29825	-RRB-	denotes	)
T8488	29825-29826	.	denotes	.
T8489	29826-29997	sentence	denotes	Significant analysis of the association of the TACCs with the centrosome and the dynamics of mitotic spindle assembly from yeast to humans has been published [5,6,21-24].
T8490	29827-29838	JJ	denotes	Significant
T8491	29839-29847	NN	denotes	analysis
T8492	29975-29984	VBN	denotes	published
T8493	29848-29850	IN	denotes	of
T8494	29851-29854	DT	denotes	the
T8495	29855-29866	NN	denotes	association
T8496	29867-29869	IN	denotes	of
T8497	29870-29873	DT	denotes	the
T8498	29874-29879	NNS	denotes	TACCs
T8499	29880-29884	IN	denotes	with
T8500	29885-29888	DT	denotes	the
T8501	29889-29899	NN	denotes	centrosome
T8502	29900-29903	CC	denotes	and
T8503	29904-29907	DT	denotes	the
T8504	29908-29916	NNS	denotes	dynamics
T8505	29917-29919	IN	denotes	of
T8506	29920-29927	JJ	denotes	mitotic
T8507	29928-29935	NN	denotes	spindle
T8508	29936-29944	NN	denotes	assembly
T8509	29945-29949	IN	denotes	from
T8510	29950-29955	NN	denotes	yeast
T8511	29956-29958	IN	denotes	to
T8512	29959-29965	NNS	denotes	humans
T8513	29966-29969	VBZ	denotes	has
T8514	29970-29974	VBN	denotes	been
T8515	29985-29986	-LRB-	denotes	[
T8516	29986-29987	CD	denotes	5
T8517	29987-29988	,	denotes	,
T8518	29988-29989	CD	denotes	6
T8519	29989-29990	,	denotes	,
T8520	29990-29992	CD	denotes	21
T8521	29992-29993	SYM	denotes	-
T8522	29993-29995	CD	denotes	24
T8523	29995-29996	-RRB-	denotes	]
T8524	29996-29997	.	denotes	.
T8525	29997-30317	sentence	denotes	From this analysis, it seems likely that the vertebrate TACC3 protein has retained this direct ancestral function, based upon its location in these structures during mitosis [27], its strong interaction with Aurora Kinase A, and the observation that it is the only human TACC protein phosphorylated by this enzyme [21].
T8526	29998-30002	IN	denotes	From
T8527	30021-30026	VBZ	denotes	seems
T8528	30003-30007	DT	denotes	this
T8529	30008-30016	NN	denotes	analysis
T8530	30016-30018	,	denotes	,
T8531	30018-30020	PRP	denotes	it
T8532	30027-30033	JJ	denotes	likely
T8533	30034-30038	IN	denotes	that
T8534	30072-30080	VBN	denotes	retained
T8535	30039-30042	DT	denotes	the
T8536	30060-30067	NN	denotes	protein
T8537	30043-30053	NN	denotes	vertebrate
T8538	30054-30059	NN	denotes	TACC3
T8539	30068-30071	VBZ	denotes	has
T8540	30081-30085	DT	denotes	this
T8541	30103-30111	NN	denotes	function
T8542	30086-30092	JJ	denotes	direct
T8543	30093-30102	JJ	denotes	ancestral
T8544	30111-30113	,	denotes	,
T8545	30113-30118	VBN	denotes	based
T8546	30119-30123	IN	denotes	upon
T8547	30124-30127	PRP$	denotes	its
T8548	30128-30136	NN	denotes	location
T8549	30137-30139	IN	denotes	in
T8550	30140-30145	DT	denotes	these
T8551	30146-30156	NNS	denotes	structures
T8552	30157-30163	IN	denotes	during
T8553	30164-30171	NN	denotes	mitosis
T8554	30172-30173	-LRB-	denotes	[
T8555	30173-30175	CD	denotes	27
T8556	30175-30176	-RRB-	denotes	]
T8557	30176-30178	,	denotes	,
T8558	30178-30181	PRP$	denotes	its
T8559	30189-30200	NN	denotes	interaction
T8560	30182-30188	JJ	denotes	strong
T8561	30201-30205	IN	denotes	with
T8562	30206-30212	NN	denotes	Aurora
T8563	30220-30221	NN	denotes	A
T8564	30213-30219	NN	denotes	Kinase
T8565	30221-30223	,	denotes	,
T8566	30223-30226	CC	denotes	and
T8567	30227-30230	DT	denotes	the
T8568	30231-30242	NN	denotes	observation
T8569	30243-30247	IN	denotes	that
T8570	30251-30253	VBZ	denotes	is
T8571	30248-30250	PRP	denotes	it
T8572	30254-30257	DT	denotes	the
T8573	30274-30281	NN	denotes	protein
T8574	30258-30262	RB	denotes	only
T8575	30263-30268	JJ	denotes	human
T8576	30269-30273	NN	denotes	TACC
T8577	30282-30296	VBN	denotes	phosphorylated
T8578	30297-30299	IN	denotes	by
T8579	30300-30304	DT	denotes	this
T8580	30305-30311	NN	denotes	enzyme
T8581	30312-30313	-LRB-	denotes	[
T8582	30313-30315	CD	denotes	21
T8583	30315-30316	-RRB-	denotes	]
T8584	30316-30317	.	denotes	.
T8585	30317-30501	sentence	denotes	However, the variability of the central domain of the vertebrate orthologues, suggests that TACC3 may also have acquired additional, and in some instances, species-specific functions.
T8586	30318-30325	RB	denotes	However
T8587	30396-30404	VBZ	denotes	suggests
T8588	30325-30327	,	denotes	,
T8589	30327-30330	DT	denotes	the
T8590	30331-30342	NN	denotes	variability
T8591	30343-30345	IN	denotes	of
T8592	30346-30349	DT	denotes	the
T8593	30358-30364	NN	denotes	domain
T8594	30350-30357	JJ	denotes	central
T8595	30365-30367	IN	denotes	of
T8596	30368-30371	DT	denotes	the
T8597	30383-30394	NNS	denotes	orthologues
T8598	30372-30382	NN	denotes	vertebrate
T8599	30394-30396	,	denotes	,
T8600	30405-30409	IN	denotes	that
T8601	30430-30438	VBN	denotes	acquired
T8602	30410-30415	NN	denotes	TACC3
T8603	30416-30419	MD	denotes	may
T8604	30420-30424	RB	denotes	also
T8605	30425-30429	VB	denotes	have
T8606	30439-30449	JJ	denotes	additional
T8607	30491-30500	NNS	denotes	functions
T8608	30449-30451	,	denotes	,
T8609	30451-30454	CC	denotes	and
T8610	30455-30457	IN	denotes	in
T8611	30482-30490	JJ	denotes	specific
T8612	30458-30462	DT	denotes	some
T8613	30463-30472	NNS	denotes	instances
T8614	30472-30474	,	denotes	,
T8615	30474-30481	NN	denotes	species
T8616	30481-30482	HYPH	denotes	-
T8617	30500-30501	.	denotes	.
T8618	30501-30711	sentence	denotes	For instance, in X. laevis, the maskin protein has acquired a binding site for the eIF4E protein, and thus a function in the coordinated control of polyadenylation and translation in the Xenopus oocyte [8,35].
T8619	30502-30505	IN	denotes	For
T8620	30553-30561	VBN	denotes	acquired
T8621	30506-30514	NN	denotes	instance
T8622	30514-30516	,	denotes	,
T8623	30516-30518	IN	denotes	in
T8624	30519-30521	NNP	denotes	X.
T8625	30522-30528	NNP	denotes	laevis
T8626	30528-30530	,	denotes	,
T8627	30530-30533	DT	denotes	the
T8628	30541-30548	NN	denotes	protein
T8629	30534-30540	NN	denotes	maskin
T8630	30549-30552	VBZ	denotes	has
T8631	30562-30563	DT	denotes	a
T8632	30572-30576	NN	denotes	site
T8633	30564-30571	NN	denotes	binding
T8634	30577-30580	IN	denotes	for
T8635	30581-30584	DT	denotes	the
T8636	30591-30598	NN	denotes	protein
T8637	30585-30590	NN	denotes	eIF4E
T8638	30598-30600	,	denotes	,
T8639	30600-30603	CC	denotes	and
T8640	30604-30608	RB	denotes	thus
T8641	30611-30619	NN	denotes	function
T8642	30609-30610	DT	denotes	a
T8643	30620-30622	IN	denotes	in
T8644	30623-30626	DT	denotes	the
T8645	30639-30646	NN	denotes	control
T8646	30627-30638	VBN	denotes	coordinated
T8647	30647-30649	IN	denotes	of
T8648	30650-30665	NN	denotes	polyadenylation
T8649	30666-30669	CC	denotes	and
T8650	30670-30681	NN	denotes	translation
T8651	30682-30684	IN	denotes	in
T8652	30685-30688	DT	denotes	the
T8653	30697-30703	NN	denotes	oocyte
T8654	30689-30696	NNP	denotes	Xenopus
T8655	30704-30705	-LRB-	denotes	[
T8656	30707-30709	CD	denotes	35
T8657	30705-30706	CD	denotes	8
T8658	30706-30707	,	denotes	,
T8659	30709-30710	-RRB-	denotes	]
T8660	30710-30711	.	denotes	.
T8661	30711-30965	sentence	denotes	A recent study has suggested that this function may be unique to maskin: although it is unclear whether the other vertebrate TACC3 proteins interact with the eIF4E/CPEB complex, the human TACC1A isoform is unable to interact with the eIF4E/CPEB complex.
T8662	30712-30713	DT	denotes	A
T8663	30721-30726	NN	denotes	study
T8664	30714-30720	JJ	denotes	recent
T8665	30731-30740	VBN	denotes	suggested
T8666	30727-30730	VBZ	denotes	has
T8667	30915-30917	VBZ	denotes	is
T8668	30741-30745	IN	denotes	that
T8669	30764-30766	VB	denotes	be
T8670	30746-30750	DT	denotes	this
T8671	30751-30759	NN	denotes	function
T8672	30760-30763	MD	denotes	may
T8673	30767-30773	JJ	denotes	unique
T8674	30774-30776	IN	denotes	to
T8675	30777-30783	NN	denotes	maskin
T8676	30783-30785	:	denotes	:
T8677	30785-30793	IN	denotes	although
T8678	30797-30799	VBZ	denotes	is
T8679	30794-30796	PRP	denotes	it
T8680	30800-30807	JJ	denotes	unclear
T8681	30808-30815	IN	denotes	whether
T8682	30852-30860	VBP	denotes	interact
T8683	30816-30819	DT	denotes	the
T8684	30843-30851	NN	denotes	proteins
T8685	30820-30825	JJ	denotes	other
T8686	30826-30836	NN	denotes	vertebrate
T8687	30837-30842	NN	denotes	TACC3
T8688	30861-30865	IN	denotes	with
T8689	30866-30869	DT	denotes	the
T8690	30881-30888	NN	denotes	complex
T8691	30870-30875	NN	denotes	eIF4E
T8692	30876-30880	NN	denotes	CPEB
T8693	30875-30876	HYPH	denotes	/
T8694	30888-30890	,	denotes	,
T8695	30890-30893	DT	denotes	the
T8696	30907-30914	NN	denotes	isoform
T8697	30894-30899	JJ	denotes	human
T8698	30900-30906	NN	denotes	TACC1A
T8699	30918-30924	JJ	denotes	unable
T8700	30925-30927	TO	denotes	to
T8701	30928-30936	VB	denotes	interact
T8702	30937-30941	IN	denotes	with
T8703	30942-30945	DT	denotes	the
T8704	30957-30964	NN	denotes	complex
T8705	30946-30951	NN	denotes	eIF4E
T8706	30952-30956	NN	denotes	CPEB
T8707	30951-30952	HYPH	denotes	/
T8708	30964-30965	.	denotes	.
T8709	30965-31128	sentence	denotes	Instead, some TACC1 isoforms have evolved a related, but distinct function by directly interacting with elements of the RNA splicing and transport machinery [19].
T8710	30966-30973	RB	denotes	Instead
T8711	31000-31007	VBN	denotes	evolved
T8712	30973-30975	,	denotes	,
T8713	30975-30979	DT	denotes	some
T8714	30986-30994	NNS	denotes	isoforms
T8715	30980-30985	NN	denotes	TACC1
T8716	30995-30999	VBP	denotes	have
T8717	31008-31009	DT	denotes	a
T8718	31032-31040	NN	denotes	function
T8719	31010-31017	JJ	denotes	related
T8720	31017-31019	,	denotes	,
T8721	31019-31022	CC	denotes	but
T8722	31023-31031	JJ	denotes	distinct
T8723	31041-31043	IN	denotes	by
T8724	31044-31052	RB	denotes	directly
T8725	31053-31064	VBG	denotes	interacting
T8726	31065-31069	IN	denotes	with
T8727	31070-31078	NNS	denotes	elements
T8728	31079-31081	IN	denotes	of
T8729	31082-31085	DT	denotes	the
T8730	31113-31122	NN	denotes	machinery
T8731	31086-31089	NN	denotes	RNA
T8732	31090-31098	NN	denotes	splicing
T8733	31099-31102	CC	denotes	and
T8734	31103-31112	NN	denotes	transport
T8735	31123-31124	-LRB-	denotes	[
T8736	31124-31126	CD	denotes	19
T8737	31126-31127	-RRB-	denotes	]
T8738	31127-31128	.	denotes	.
T8739	31128-31322	sentence	denotes	To further characterize the evolving functions of the TACC proteins, we have used an unbiased yeast two hybrid screening method to identify proteins that bind to the human TACC proteins [3,34].
T8740	31129-31131	TO	denotes	To
T8741	31140-31152	VB	denotes	characterize
T8742	31132-31139	RB	denotes	further
T8743	31206-31210	VBN	denotes	used
T8744	31153-31156	DT	denotes	the
T8745	31166-31175	NNS	denotes	functions
T8746	31157-31165	VBG	denotes	evolving
T8747	31176-31178	IN	denotes	of
T8748	31179-31182	DT	denotes	the
T8749	31188-31196	NN	denotes	proteins
T8750	31183-31187	NN	denotes	TACC
T8751	31196-31198	,	denotes	,
T8752	31198-31200	PRP	denotes	we
T8753	31201-31205	VBP	denotes	have
T8754	31211-31213	DT	denotes	an
T8755	31250-31256	NN	denotes	method
T8756	31214-31222	JJ	denotes	unbiased
T8757	31223-31228	NN	denotes	yeast
T8758	31229-31232	CD	denotes	two
T8759	31233-31239	NN	denotes	hybrid
T8760	31240-31249	NN	denotes	screening
T8761	31257-31259	TO	denotes	to
T8762	31260-31268	VB	denotes	identify
T8763	31269-31277	NN	denotes	proteins
T8764	31278-31282	WDT	denotes	that
T8765	31283-31287	VBP	denotes	bind
T8766	31288-31290	IN	denotes	to
T8767	31291-31294	DT	denotes	the
T8768	31306-31314	NN	denotes	proteins
T8769	31295-31300	JJ	denotes	human
T8770	31301-31305	NN	denotes	TACC
T8771	31315-31316	-LRB-	denotes	[
T8772	31318-31320	CD	denotes	34
T8773	31316-31317	CD	denotes	3
T8774	31317-31318	,	denotes	,
T8775	31320-31321	-RRB-	denotes	]
T8776	31321-31322	.	denotes	.
T8777	31322-31584	sentence	denotes	In a screen of a MATCHMAKER fetal brain library (BD Biosciences Clontech), in addition to isolating the histone acetyltransferase hGCN5L2 [34], we also identified the β3 isoform of retinoid-X receptor β as a protein that interacts with the TACC domain of TACC2.
T8778	31323-31325	IN	denotes	In
T8779	31475-31485	VBD	denotes	identified
T8780	31326-31327	DT	denotes	a
T8781	31328-31334	NN	denotes	screen
T8782	31335-31337	IN	denotes	of
T8783	31338-31339	DT	denotes	a
T8784	31363-31370	NN	denotes	library
T8785	31340-31350	NN	denotes	MATCHMAKER
T8786	31351-31356	JJ	denotes	fetal
T8787	31357-31362	NN	denotes	brain
T8788	31371-31372	-LRB-	denotes	(
T8789	31387-31395	NNP	denotes	Clontech
T8790	31372-31374	NNP	denotes	BD
T8791	31375-31386	NNPS	denotes	Biosciences
T8792	31395-31396	-RRB-	denotes	)
T8793	31396-31398	,	denotes	,
T8794	31398-31400	IN	denotes	in
T8795	31401-31409	NN	denotes	addition
T8796	31410-31412	IN	denotes	to
T8797	31413-31422	VBG	denotes	isolating
T8798	31423-31426	DT	denotes	the
T8799	31435-31452	NN	denotes	acetyltransferase
T8800	31427-31434	NN	denotes	histone
T8801	31453-31460	NN	denotes	hGCN5L2
T8802	31461-31462	-LRB-	denotes	[
T8803	31462-31464	CD	denotes	34
T8804	31464-31465	-RRB-	denotes	]
T8805	31465-31467	,	denotes	,
T8806	31467-31469	PRP	denotes	we
T8807	31470-31474	RB	denotes	also
T8808	31486-31489	DT	denotes	the
T8809	31493-31500	NN	denotes	isoform
T8810	31490-31492	NN	denotes	β3
T8811	31501-31503	IN	denotes	of
T8812	31504-31512	NN	denotes	retinoid
T8813	31513-31514	NN	denotes	X
T8814	31512-31513	HYPH	denotes	-
T8815	31524-31525	NN	denotes	β
T8816	31515-31523	NN	denotes	receptor
T8817	31526-31528	IN	denotes	as
T8818	31529-31530	DT	denotes	a
T8819	31531-31538	NN	denotes	protein
T8820	31539-31543	WDT	denotes	that
T8821	31544-31553	VBZ	denotes	interacts
T8822	31554-31558	IN	denotes	with
T8823	31559-31562	DT	denotes	the
T8824	31568-31574	NN	denotes	domain
T8825	31563-31567	NN	denotes	TACC
T8826	31575-31577	IN	denotes	of
T8827	31578-31583	NN	denotes	TACC2
T8828	31583-31584	.	denotes	.
T8829	31584-31670	sentence	denotes	As shown in Fig. 7, this interaction is confirmed in vitro by GST-pull down analysis.
T8830	31585-31587	IN	denotes	As
T8831	31588-31593	VBN	denotes	shown
T8832	31625-31634	VBN	denotes	confirmed
T8833	31594-31596	IN	denotes	in
T8834	31597-31601	NN	denotes	Fig.
T8835	31602-31603	CD	denotes	7
T8836	31603-31605	,	denotes	,
T8837	31605-31609	DT	denotes	this
T8838	31610-31621	NN	denotes	interaction
T8839	31622-31624	VBZ	denotes	is
T8840	31635-31637	FW	denotes	in
T8841	31638-31643	FW	denotes	vitro
T8842	31644-31646	IN	denotes	by
T8843	31647-31650	NN	denotes	GST
T8844	31651-31655	VB	denotes	pull
T8845	31650-31651	HYPH	denotes	-
T8846	31661-31669	NN	denotes	analysis
T8847	31656-31660	RP	denotes	down
T8848	31669-31670	.	denotes	.
T8849	31670-31839	sentence	denotes	Significantly, RXRβ is a close family relative of the nuclear hormone receptor, nhr-86, from C. elegans, which interacts with the ceTAC binding protein lin36 (Fig. 6A).
T8850	31671-31684	RB	denotes	Significantly
T8851	31691-31693	VBZ	denotes	is
T8852	31684-31686	,	denotes	,
T8853	31686-31690	NN	denotes	RXRβ
T8854	31694-31695	DT	denotes	a
T8855	31702-31708	NN	denotes	family
T8856	31696-31701	JJ	denotes	close
T8857	31709-31717	JJ	denotes	relative
T8858	31718-31720	IN	denotes	of
T8859	31721-31724	DT	denotes	the
T8860	31741-31749	NN	denotes	receptor
T8861	31725-31732	JJ	denotes	nuclear
T8862	31733-31740	NN	denotes	hormone
T8863	31749-31751	,	denotes	,
T8864	31751-31754	NN	denotes	nhr
T8865	31754-31755	HYPH	denotes	-
T8866	31755-31757	CD	denotes	86
T8867	31757-31759	,	denotes	,
T8868	31759-31763	IN	denotes	from
T8869	31764-31766	NNP	denotes	C.
T8870	31767-31774	NNP	denotes	elegans
T8871	31774-31776	,	denotes	,
T8872	31776-31781	WDT	denotes	which
T8873	31782-31791	VBZ	denotes	interacts
T8874	31792-31796	IN	denotes	with
T8875	31797-31800	DT	denotes	the
T8876	31815-31822	NN	denotes	protein
T8877	31801-31806	NN	denotes	ceTAC
T8878	31807-31814	NN	denotes	binding
T8879	31823-31828	NN	denotes	lin36
T8880	31829-31830	-LRB-	denotes	(
T8881	31830-31834	NN	denotes	Fig.
T8882	31835-31837	CD	denotes	6A
T8883	31837-31838	-RRB-	denotes	)
T8884	31838-31839	.	denotes	.
T8885	31839-32104	sentence	denotes	This suggests that while protostome TACCs may require additional protein factors to interact with such components, the TACCs in higher organisms may have evolved the ability to directly interact with some of the proteins in the predicted interaction map (Fig. 6E).
T8886	31840-31844	DT	denotes	This
T8887	31845-31853	VBZ	denotes	suggests
T8888	31854-31858	IN	denotes	that
T8889	31994-32001	VBN	denotes	evolved
T8890	31859-31864	IN	denotes	while
T8891	31886-31893	VB	denotes	require
T8892	31865-31875	NN	denotes	protostome
T8893	31876-31881	NNS	denotes	TACCs
T8894	31882-31885	MD	denotes	may
T8895	31894-31904	JJ	denotes	additional
T8896	31913-31920	NNS	denotes	factors
T8897	31905-31912	NN	denotes	protein
T8898	31921-31923	TO	denotes	to
T8899	31924-31932	VB	denotes	interact
T8900	31933-31937	IN	denotes	with
T8901	31938-31942	JJ	denotes	such
T8902	31943-31953	NNS	denotes	components
T8903	31953-31955	,	denotes	,
T8904	31955-31958	DT	denotes	the
T8905	31959-31964	NNS	denotes	TACCs
T8906	31965-31967	IN	denotes	in
T8907	31968-31974	JJR	denotes	higher
T8908	31975-31984	NNS	denotes	organisms
T8909	31985-31988	MD	denotes	may
T8910	31989-31993	VB	denotes	have
T8911	32002-32005	DT	denotes	the
T8912	32006-32013	NN	denotes	ability
T8913	32014-32016	TO	denotes	to
T8914	32026-32034	VB	denotes	interact
T8915	32017-32025	RB	denotes	directly
T8916	32035-32039	IN	denotes	with
T8917	32040-32044	DT	denotes	some
T8918	32045-32047	IN	denotes	of
T8919	32048-32051	DT	denotes	the
T8920	32052-32060	NN	denotes	proteins
T8921	32061-32063	IN	denotes	in
T8922	32064-32067	DT	denotes	the
T8923	32090-32093	NN	denotes	map
T8924	32068-32077	VBN	denotes	predicted
T8925	32078-32089	NN	denotes	interaction
T8926	32094-32095	-LRB-	denotes	(
T8927	32095-32099	NN	denotes	Fig.
T8928	32100-32102	CD	denotes	6E
T8929	32102-32103	-RRB-	denotes	)
T8930	32103-32104	.	denotes	.
T8931	32104-32229	sentence	denotes	Indeed, this appears to be directly linked to the acquisition of new domains and duplication of the chordate TACC precursor.
T8932	32105-32111	RB	denotes	Indeed
T8933	32118-32125	VBZ	denotes	appears
T8934	32111-32113	,	denotes	,
T8935	32113-32117	DT	denotes	this
T8936	32126-32128	TO	denotes	to
T8937	32141-32147	VBN	denotes	linked
T8938	32129-32131	VB	denotes	be
T8939	32132-32140	RB	denotes	directly
T8940	32148-32150	IN	denotes	to
T8941	32151-32154	DT	denotes	the
T8942	32155-32166	NN	denotes	acquisition
T8943	32167-32169	IN	denotes	of
T8944	32170-32173	JJ	denotes	new
T8945	32174-32181	NNS	denotes	domains
T8946	32182-32185	CC	denotes	and
T8947	32186-32197	NN	denotes	duplication
T8948	32198-32200	IN	denotes	of
T8949	32201-32204	DT	denotes	the
T8950	32219-32228	NN	denotes	precursor
T8951	32205-32213	NN	denotes	chordate
T8952	32214-32218	NN	denotes	TACC
T8953	32228-32229	.	denotes	.
T8954	32229-32410	sentence	denotes	In fact, the first identified function of a vertebrate TACC protein was as a transcriptional coactivator acting through a direct interaction with the ARNT transcription factor [7].
T8955	32230-32232	IN	denotes	In
T8956	32298-32301	VBD	denotes	was
T8957	32233-32237	NN	denotes	fact
T8958	32237-32239	,	denotes	,
T8959	32239-32242	DT	denotes	the
T8960	32260-32268	NN	denotes	function
T8961	32243-32248	JJ	denotes	first
T8962	32249-32259	VBN	denotes	identified
T8963	32269-32271	IN	denotes	of
T8964	32272-32273	DT	denotes	a
T8965	32290-32297	NN	denotes	protein
T8966	32274-32284	NN	denotes	vertebrate
T8967	32285-32289	NN	denotes	TACC
T8968	32302-32304	IN	denotes	as
T8969	32305-32306	DT	denotes	a
T8970	32323-32334	NN	denotes	coactivator
T8971	32307-32322	JJ	denotes	transcriptional
T8972	32335-32341	VBG	denotes	acting
T8973	32342-32349	IN	denotes	through
T8974	32350-32351	DT	denotes	a
T8975	32359-32370	NN	denotes	interaction
T8976	32352-32358	JJ	denotes	direct
T8977	32371-32375	IN	denotes	with
T8978	32376-32379	DT	denotes	the
T8979	32399-32405	NN	denotes	factor
T8980	32380-32384	NN	denotes	ARNT
T8981	32385-32398	NN	denotes	transcription
T8982	32406-32407	-LRB-	denotes	[
T8983	32407-32408	CD	denotes	7
T8984	32408-32409	-RRB-	denotes	]
T8985	32409-32410	.	denotes	.
T8986	32410-32583	sentence	denotes	It is also intriguing that the deuterostome specific SDP repeat interacts with GAS41, a component/accessory factor of the human SWI/SNF chromatin remodeling complex [3,15].
T8987	32411-32413	PRP	denotes	It
T8988	32414-32416	VBZ	denotes	is
T8989	32417-32421	RB	denotes	also
T8990	32422-32432	JJ	denotes	intriguing
T8991	32433-32437	IN	denotes	that
T8992	32475-32484	VBZ	denotes	interacts
T8993	32438-32441	DT	denotes	the
T8994	32468-32474	NN	denotes	repeat
T8995	32442-32454	NN	denotes	deuterostome
T8996	32455-32463	JJ	denotes	specific
T8997	32464-32467	NN	denotes	SDP
T8998	32485-32489	IN	denotes	with
T8999	32490-32495	NN	denotes	GAS41
T9000	32495-32497	,	denotes	,
T9001	32497-32498	DT	denotes	a
T9002	32519-32525	NN	denotes	factor
T9003	32499-32508	NN	denotes	component
T9004	32509-32518	NN	denotes	accessory
T9005	32508-32509	HYPH	denotes	/
T9006	32526-32528	IN	denotes	of
T9007	32529-32532	DT	denotes	the
T9008	32568-32575	NN	denotes	complex
T9009	32533-32538	JJ	denotes	human
T9010	32539-32542	NN	denotes	SWI
T9011	32543-32546	NN	denotes	SNF
T9012	32542-32543	HYPH	denotes	/
T9013	32547-32556	NN	denotes	chromatin
T9014	32557-32567	NN	denotes	remodeling
T9015	32576-32577	-LRB-	denotes	[
T9016	32579-32581	CD	denotes	15
T9017	32577-32578	CD	denotes	3
T9018	32578-32579	,	denotes	,
T9019	32581-32582	-RRB-	denotes	]
T9020	32582-32583	.	denotes	.
T9021	32583-32757	sentence	denotes	Although there is a D. melanogaster homologue of GAS41, dmGAS41, the large scale proteomic interaction database does not indicate a direct interaction of dmGAS41 with DTACC.
T9022	32584-32592	IN	denotes	Although
T9023	32599-32601	VBZ	denotes	is
T9024	32593-32598	EX	denotes	there
T9025	32705-32713	VB	denotes	indicate
T9026	32602-32603	DT	denotes	a
T9027	32620-32629	NN	denotes	homologue
T9028	32604-32606	NNP	denotes	D.
T9029	32607-32619	NNP	denotes	melanogaster
T9030	32630-32632	IN	denotes	of
T9031	32633-32638	NN	denotes	GAS41
T9032	32638-32640	,	denotes	,
T9033	32640-32647	NN	denotes	dmGAS41
T9034	32647-32649	,	denotes	,
T9035	32649-32652	DT	denotes	the
T9036	32687-32695	NN	denotes	database
T9037	32653-32658	JJ	denotes	large
T9038	32659-32664	NN	denotes	scale
T9039	32675-32686	NN	denotes	interaction
T9040	32665-32674	JJ	denotes	proteomic
T9041	32696-32700	VBZ	denotes	does
T9042	32701-32704	RB	denotes	not
T9043	32714-32715	DT	denotes	a
T9044	32723-32734	NN	denotes	interaction
T9045	32716-32722	JJ	denotes	direct
T9046	32735-32737	IN	denotes	of
T9047	32738-32745	NN	denotes	dmGAS41
T9048	32746-32750	IN	denotes	with
T9049	32751-32756	NN	denotes	DTACC
T9050	32756-32757	.	denotes	.
T9051	32757-32842	sentence	denotes	This may be due to the lack of the SDP repeat region in the Drosophila TACC protein.
T9052	32758-32762	DT	denotes	This
T9053	32767-32769	VB	denotes	be
T9054	32763-32766	MD	denotes	may
T9055	32770-32773	IN	denotes	due
T9056	32774-32776	IN	denotes	to
T9057	32777-32780	DT	denotes	the
T9058	32781-32785	NN	denotes	lack
T9059	32786-32788	IN	denotes	of
T9060	32789-32792	DT	denotes	the
T9061	32804-32810	NN	denotes	region
T9062	32793-32796	NN	denotes	SDP
T9063	32797-32803	NN	denotes	repeat
T9064	32811-32813	IN	denotes	in
T9065	32814-32817	DT	denotes	the
T9066	32834-32841	NN	denotes	protein
T9067	32818-32828	NNP	denotes	Drosophila
T9068	32829-32833	NN	denotes	TACC
T9069	32841-32842	.	denotes	.
T9070	32842-33038	sentence	denotes	This further suggests that the vertebrate TACCs have gained the specific ability to direct interact with transcriptional regulatory complexes, and that bridging protein(s) are no longer required.
T9071	32843-32847	DT	denotes	This
T9072	32856-32864	VBZ	denotes	suggests
T9073	32848-32855	RB	denotes	further
T9074	32865-32869	IN	denotes	that
T9075	32896-32902	VBN	denotes	gained
T9076	32870-32873	DT	denotes	the
T9077	32885-32890	NNS	denotes	TACCs
T9078	32874-32884	NN	denotes	vertebrate
T9079	32891-32895	VBP	denotes	have
T9080	32903-32906	DT	denotes	the
T9081	32916-32923	NN	denotes	ability
T9082	32907-32915	JJ	denotes	specific
T9083	32924-32926	TO	denotes	to
T9084	32934-32942	VB	denotes	interact
T9085	32927-32933	JJ	denotes	direct
T9086	32943-32947	IN	denotes	with
T9087	32948-32963	JJ	denotes	transcriptional
T9088	32975-32984	NNS	denotes	complexes
T9089	32964-32974	JJ	denotes	regulatory
T9090	32984-32986	,	denotes	,
T9091	32986-32989	CC	denotes	and
T9092	32990-32994	IN	denotes	that
T9093	33029-33037	VBN	denotes	required
T9094	32995-33003	VBG	denotes	bridging
T9095	33004-33011	NN	denotes	protein
T9096	33011-33012	-LRB-	denotes	(
T9097	33012-33013	AFX	denotes	s
T9098	33013-33014	-RRB-	denotes	)
T9099	33015-33018	VBP	denotes	are
T9100	33019-33021	RB	denotes	no
T9101	33022-33028	RBR	denotes	longer
T9102	33037-33038	.	denotes	.
T9103	33038-33295	sentence	denotes	Thus, where the ceTAC protein is only composed of the TACC domain, the significantly larger TACC family members in higher protostomes and deuterostomes may have integrated one or more functions of the bridging protein (in this case lin15A, lin36 or lin37).
T9104	33039-33043	RB	denotes	Thus
T9105	33200-33210	VBN	denotes	integrated
T9106	33043-33045	,	denotes	,
T9107	33045-33050	WRB	denotes	where
T9108	33077-33085	VBN	denotes	composed
T9109	33051-33054	DT	denotes	the
T9110	33061-33068	NN	denotes	protein
T9111	33055-33060	NN	denotes	ceTAC
T9112	33069-33071	VBZ	denotes	is
T9113	33072-33076	RB	denotes	only
T9114	33086-33088	IN	denotes	of
T9115	33089-33092	DT	denotes	the
T9116	33098-33104	NN	denotes	domain
T9117	33093-33097	NN	denotes	TACC
T9118	33104-33106	,	denotes	,
T9119	33106-33109	DT	denotes	the
T9120	33143-33150	NNS	denotes	members
T9121	33110-33123	RB	denotes	significantly
T9122	33124-33130	JJR	denotes	larger
T9123	33131-33135	NN	denotes	TACC
T9124	33136-33142	NN	denotes	family
T9125	33151-33153	IN	denotes	in
T9126	33154-33160	JJR	denotes	higher
T9127	33161-33172	NNS	denotes	protostomes
T9128	33173-33176	CC	denotes	and
T9129	33177-33190	NNS	denotes	deuterostomes
T9130	33191-33194	MD	denotes	may
T9131	33195-33199	VB	denotes	have
T9132	33211-33214	CD	denotes	one
T9133	33223-33232	NNS	denotes	functions
T9134	33215-33217	CC	denotes	or
T9135	33218-33222	JJR	denotes	more
T9136	33233-33235	IN	denotes	of
T9137	33236-33239	DT	denotes	the
T9138	33249-33256	NN	denotes	protein
T9139	33240-33248	VBG	denotes	bridging
T9140	33257-33258	-LRB-	denotes	(
T9141	33258-33260	IN	denotes	in
T9142	33261-33265	DT	denotes	this
T9143	33266-33270	NN	denotes	case
T9144	33271-33277	NN	denotes	lin15A
T9145	33277-33279	,	denotes	,
T9146	33279-33284	NN	denotes	lin36
T9147	33285-33287	CC	denotes	or
T9148	33288-33293	NN	denotes	lin37
T9149	33293-33294	-RRB-	denotes	)
T9150	33294-33295	.	denotes	.
T9151	33295-33517	sentence	denotes	This may also explain the absence of lin15A, lin36 and lin37 homologues in higher organisms, as they were no longer under selective evolutionary pressure to remain within the complex, and thus lost in the evolving genome.
T9152	33296-33300	DT	denotes	This
T9153	33310-33317	VB	denotes	explain
T9154	33301-33304	MD	denotes	may
T9155	33305-33309	RB	denotes	also
T9156	33318-33321	DT	denotes	the
T9157	33322-33329	NN	denotes	absence
T9158	33330-33332	IN	denotes	of
T9159	33333-33339	NN	denotes	lin15A
T9160	33357-33367	NNS	denotes	homologues
T9161	33339-33341	,	denotes	,
T9162	33341-33346	NN	denotes	lin36
T9163	33347-33350	CC	denotes	and
T9164	33351-33356	NN	denotes	lin37
T9165	33368-33370	IN	denotes	in
T9166	33371-33377	JJR	denotes	higher
T9167	33378-33387	NNS	denotes	organisms
T9168	33387-33389	,	denotes	,
T9169	33389-33391	IN	denotes	as
T9170	33397-33401	VBD	denotes	were
T9171	33392-33396	PRP	denotes	they
T9172	33402-33404	RB	denotes	no
T9173	33405-33411	RBR	denotes	longer
T9174	33412-33417	IN	denotes	under
T9175	33418-33427	JJ	denotes	selective
T9176	33441-33449	NN	denotes	pressure
T9177	33428-33440	JJ	denotes	evolutionary
T9178	33450-33452	TO	denotes	to
T9179	33453-33459	VB	denotes	remain
T9180	33460-33466	IN	denotes	within
T9181	33467-33470	DT	denotes	the
T9182	33471-33478	NN	denotes	complex
T9183	33478-33480	,	denotes	,
T9184	33480-33483	CC	denotes	and
T9185	33484-33488	RB	denotes	thus
T9186	33489-33493	VBN	denotes	lost
T9187	33494-33496	IN	denotes	in
T9188	33497-33500	DT	denotes	the
T9189	33510-33516	NN	denotes	genome
T9190	33501-33509	VBG	denotes	evolving
T9191	33516-33517	.	denotes	.
T13816	27930-27932	IN	denotes	In
T13817	27949-27956	VBZ	denotes	denotes
T12469	1346-1358	JJ	denotes	Phylogenetic
T12470	1359-1367	NN	denotes	analysis
T12471	1368-1370	IN	denotes	of
T12472	1371-1374	DT	denotes	the
T12473	1387-1394	NNS	denotes	members
T12474	1375-1379	NN	denotes	TACC
T12475	1380-1386	NN	denotes	family
T12476	1395-1403	VBN	denotes	compared
T12477	1404-1406	IN	denotes	to
T12478	1407-1412	JJ	denotes	other
T12479	1425-1433	NN	denotes	proteins
T12480	1413-1419	VBN	denotes	coiled
T12481	1420-1424	NN	denotes	coil
T12482	1433-1434	.	denotes	.
T12483	1434-1509	sentence	denotes	The phylogenetic tree was constructed as described in the Methods section.
T12484	1435-1438	DT	denotes	The
T12485	1452-1456	NN	denotes	tree
T12486	1439-1451	JJ	denotes	phylogenetic
T12487	1461-1472	VBN	denotes	constructed
T12488	1457-1460	VBD	denotes	was
T12489	1473-1475	IN	denotes	as
T12490	1476-1485	VBN	denotes	described
T12491	1486-1488	IN	denotes	in
T12492	1489-1492	DT	denotes	the
T12493	1501-1508	NN	denotes	section
T12494	1493-1500	NNS	denotes	Methods
T12495	1508-1509	.	denotes	.
T12496	1509-1677	sentence	denotes	The TACC family defines a separate subfamily of coiled coil containing proteins, distinct from other coiled coil families such as the keratins, RHAMM and tropomyosins.
T12497	1510-1513	DT	denotes	The
T12498	1519-1525	NN	denotes	family
T12499	1514-1518	NN	denotes	TACC
T12500	1526-1533	VBZ	denotes	defines
T12501	1534-1535	DT	denotes	a
T12502	1545-1554	NN	denotes	subfamily
T12503	1536-1544	JJ	denotes	separate
T12504	1555-1557	IN	denotes	of
T12505	1558-1564	VBN	denotes	coiled
T12506	1565-1569	NN	denotes	coil
T12507	1570-1580	VBG	denotes	containing
T12508	1581-1589	NN	denotes	proteins
T12509	1589-1591	,	denotes	,
T12510	1591-1599	JJ	denotes	distinct
T12511	1600-1604	IN	denotes	from
T12512	1605-1610	JJ	denotes	other
T12513	1623-1631	NNS	denotes	families
T12514	1611-1617	VBN	denotes	coiled
T12515	1618-1622	NN	denotes	coil
T12516	1632-1636	JJ	denotes	such
T12517	1637-1639	IN	denotes	as
T12518	1640-1643	DT	denotes	the
T12519	1644-1652	NNS	denotes	keratins
T12520	1652-1654	,	denotes	,
T12521	1654-1659	NN	denotes	RHAMM
T12522	1660-1663	CC	denotes	and
T12523	1664-1676	NNS	denotes	tropomyosins
T12524	1676-1677	.	denotes	.
T12525	1677-1827	sentence	denotes	Note that the RHAMM proteins form a separate branch more closely related to the tropomyosins and kinesin like proteins (KLP), than the TACC proteins.
T12526	1678-1682	VB	denotes	Note
T12527	1683-1687	IN	denotes	that
T12528	1707-1711	VBP	denotes	form
T12529	1688-1691	DT	denotes	the
T12530	1698-1706	NN	denotes	proteins
T12531	1692-1697	NN	denotes	RHAMM
T12532	1712-1713	DT	denotes	a
T12533	1723-1729	NN	denotes	branch
T12534	1714-1722	JJ	denotes	separate
T12535	1730-1734	RBR	denotes	more
T12536	1735-1742	RB	denotes	closely
T12537	1743-1750	JJ	denotes	related
T12538	1751-1753	IN	denotes	to
T12539	1754-1757	DT	denotes	the
T12540	1758-1770	NNS	denotes	tropomyosins
T12541	1771-1774	CC	denotes	and
T12542	1775-1782	NN	denotes	kinesin
T12543	1783-1787	JJ	denotes	like
T12544	1788-1796	NN	denotes	proteins
T12545	1797-1798	-LRB-	denotes	(
T12546	1798-1801	NN	denotes	KLP
T12547	1801-1802	-RRB-	denotes	)
T12548	1802-1804	,	denotes	,
T12549	1804-1808	IN	denotes	than
T12550	1809-1812	DT	denotes	the
T12551	1818-1826	NN	denotes	proteins
T12552	1813-1817	NN	denotes	TACC
T12553	1826-1827	.	denotes	.
T12611	11291-11297	JJ	denotes	Linear
T12612	11298-11310	NN	denotes	organization
T12613	11311-11313	IN	denotes	of
T12614	11314-11318	NN	denotes	gene
T12615	11319-11327	NNS	denotes	clusters
T12616	11328-11337	VBG	denotes	centering
T12617	11338-11342	IN	denotes	upon
T12618	11343-11346	DT	denotes	the
T12619	11359-11363	NNS	denotes	loci
T12620	11347-11358	JJ	denotes	chromosomal
T12621	11364-11366	IN	denotes	of
T12622	11367-11370	DT	denotes	the
T12623	11376-11381	NNS	denotes	genes
T12624	11371-11375	NN	denotes	FGFR
T12625	11382-11384	IN	denotes	in
T12626	11385-11391	NNS	denotes	humans
T12627	11391-11392	.	denotes	.
T12628	11392-11679	sentence	denotes	Paralogous genes present in at least two of the four loci are shown, with the exception of the region between GPX3 and NKX2E on chromosome 5, which appears to represent a series of intervening genes inserted after duplication of the 4p16/5q32-35 clusters, and genes mentioned in Fig. 3.
T12629	11393-11403	JJ	denotes	Paralogous
T12630	11404-11409	NNS	denotes	genes
T12631	11455-11460	VBN	denotes	shown
T12632	11410-11417	JJ	denotes	present
T12633	11418-11420	IN	denotes	in
T12634	11421-11423	RB	denotes	at
T12635	11430-11433	CD	denotes	two
T12636	11424-11429	RBS	denotes	least
T12637	11434-11436	IN	denotes	of
T12638	11437-11440	DT	denotes	the
T12639	11446-11450	NNS	denotes	loci
T12640	11441-11445	CD	denotes	four
T12641	11451-11454	VBP	denotes	are
T12642	11460-11462	,	denotes	,
T12643	11462-11466	IN	denotes	with
T12644	11467-11470	DT	denotes	the
T12645	11471-11480	NN	denotes	exception
T12646	11481-11483	IN	denotes	of
T12647	11484-11487	DT	denotes	the
T12648	11488-11494	NN	denotes	region
T12649	11495-11502	IN	denotes	between
T12650	11503-11507	NN	denotes	GPX3
T12651	11508-11511	CC	denotes	and
T12652	11512-11517	NN	denotes	NKX2E
T12653	11518-11520	IN	denotes	on
T12654	11521-11531	NN	denotes	chromosome
T12655	11532-11533	CD	denotes	5
T12656	11533-11535	,	denotes	,
T12657	11535-11540	WDT	denotes	which
T12658	11541-11548	VBZ	denotes	appears
T12659	11549-11551	TO	denotes	to
T12660	11552-11561	VB	denotes	represent
T12661	11562-11563	DT	denotes	a
T12662	11564-11570	NN	denotes	series
T12663	11571-11573	IN	denotes	of
T12664	11574-11585	VBG	denotes	intervening
T12665	11586-11591	NNS	denotes	genes
T12666	11592-11600	VBN	denotes	inserted
T12667	11601-11606	IN	denotes	after
T12668	11607-11618	NN	denotes	duplication
T12669	11619-11621	IN	denotes	of
T12670	11622-11625	DT	denotes	the
T12671	11639-11647	NNS	denotes	clusters
T12672	11626-11630	NN	denotes	4p16
T12673	11631-11635	NN	denotes	5q32
T12674	11630-11631	HYPH	denotes	/
T12675	11635-11636	HYPH	denotes	-
T12676	11636-11638	CD	denotes	35
T12677	11647-11649	,	denotes	,
T12678	11649-11652	CC	denotes	and
T12679	11653-11658	NNS	denotes	genes
T12680	11659-11668	VBN	denotes	mentioned
T12681	11669-11671	IN	denotes	in
T12682	11672-11676	NN	denotes	Fig.
T12683	11677-11678	CD	denotes	3
T12684	11678-11679	.	denotes	.
T12685	11679-11749	sentence	denotes	Corresponding syntenic mouse chromosomal regions (mm*) are indicated.
T12686	11680-11693	VBG	denotes	Corresponding
T12687	11721-11728	NNS	denotes	regions
T12688	11694-11702	JJ	denotes	syntenic
T12689	11703-11708	NN	denotes	mouse
T12690	11709-11720	JJ	denotes	chromosomal
T12691	11739-11748	VBN	denotes	indicated
T12692	11729-11730	-LRB-	denotes	(
T12693	11730-11732	NNP	denotes	mm
T12694	11732-11733	SYM	denotes	*
T12695	11733-11734	-RRB-	denotes	)
T12696	11735-11738	VBP	denotes	are
T12697	11748-11749	.	denotes	.
T12698	11749-11857	sentence	denotes	Takifugu rubripes scaffolds are shown (TR*) that contain more than one homologous gene from these clusters.
T12699	11750-11758	NNP	denotes	Takifugu
T12700	11759-11767	NNP	denotes	rubripes
T12701	11768-11777	NNS	denotes	scaffolds
T12702	11782-11787	VBN	denotes	shown
T12703	11778-11781	VBP	denotes	are
T12704	11788-11789	-LRB-	denotes	(
T12705	11789-11791	NN	denotes	TR
T12706	11791-11792	SYM	denotes	*
T12707	11792-11793	-RRB-	denotes	)
T12708	11794-11798	WDT	denotes	that
T12709	11799-11806	VBP	denotes	contain
T12710	11807-11811	JJR	denotes	more
T12711	11817-11820	CD	denotes	one
T12712	11812-11816	IN	denotes	than
T12713	11832-11836	NN	denotes	gene
T12714	11821-11831	JJ	denotes	homologous
T12715	11837-11841	IN	denotes	from
T12716	11842-11847	DT	denotes	these
T12717	11848-11856	NNS	denotes	clusters
T12718	11856-11857	.	denotes	.
T12719	11857-11950	sentence	denotes	Further details on the location of paralogous genes can be found in [see Additional file 1].
T12720	11858-11865	JJ	denotes	Further
T12721	11866-11873	NNS	denotes	details
T12722	11917-11922	VBN	denotes	found
T12723	11874-11876	IN	denotes	on
T12724	11877-11880	DT	denotes	the
T12725	11881-11889	NN	denotes	location
T12726	11890-11892	IN	denotes	of
T12727	11893-11903	JJ	denotes	paralogous
T12728	11904-11909	NNS	denotes	genes
T12729	11910-11913	MD	denotes	can
T12730	11914-11916	VB	denotes	be
T12731	11923-11925	IN	denotes	in
T12732	11926-11927	-LRB-	denotes	[
T12733	11927-11930	VB	denotes	see
T12734	11931-11941	JJ	denotes	Additional
T12735	11942-11946	NN	denotes	file
T12736	11947-11948	CD	denotes	1
T12737	11948-11949	-RRB-	denotes	]
T12738	11949-11950	.	denotes	.
T12814	15893-15902	NN	denotes	Formation
T12815	15903-15905	IN	denotes	of
T12816	15906-15919	NNS	denotes	protoclusters
T12817	15920-15922	IN	denotes	in
T12818	15923-15931	NNP	denotes	Takifugu
T12819	15932-15940	NNP	denotes	rubripes
T12820	15941-15944	CC	denotes	and
T12821	15945-15950	NNP	denotes	Ciona
T12822	15951-15963	NNP	denotes	intestinalis
T12823	15963-15965	:	denotes	:
T12824	15965-15966	-LRB-	denotes	(
T12825	15966-15967	LS	denotes	A
T12826	15965-16066	sentence	denotes	(A): Structure of the genomic scaffolds containing the Takifugu rubripes trTACC1A and trTACC1B genes.
T12827	15970-15979	NN	denotes	Structure
T12828	15967-15968	-RRB-	denotes	)
T12829	15968-15970	:	denotes	:
T12830	15980-15982	IN	denotes	of
T12831	15983-15986	DT	denotes	the
T12832	15995-16004	NNS	denotes	scaffolds
T12833	15987-15994	JJ	denotes	genomic
T12834	16005-16015	VBG	denotes	containing
T12835	16016-16019	DT	denotes	the
T12836	16060-16065	NNS	denotes	genes
T12837	16020-16028	NNP	denotes	Takifugu
T12838	16029-16037	NNS	denotes	rubripes
T12839	16038-16046	NN	denotes	trTACC1A
T12840	16047-16050	CC	denotes	and
T12841	16051-16059	NN	denotes	trTACC1B
T12842	16065-16066	.	denotes	.
T12843	16066-16225	sentence	denotes	Scaffold 12, the site for the trTACC1A gene contains genes found with either homologues or orthologues on the distal long arm of human chromosome 10 and 4p16.
T12844	16067-16075	NN	denotes	Scaffold
T12845	16111-16119	VBZ	denotes	contains
T12846	16076-16078	CD	denotes	12
T12847	16078-16080	,	denotes	,
T12848	16080-16083	DT	denotes	the
T12849	16084-16088	NN	denotes	site
T12850	16089-16092	IN	denotes	for
T12851	16093-16096	DT	denotes	the
T12852	16106-16110	NN	denotes	gene
T12853	16097-16105	NN	denotes	trTACC1A
T12854	16120-16125	NNS	denotes	genes
T12855	16126-16131	VBN	denotes	found
T12856	16132-16136	IN	denotes	with
T12857	16137-16143	CC	denotes	either
T12858	16144-16154	NNS	denotes	homologues
T12859	16155-16157	CC	denotes	or
T12860	16158-16169	NNS	denotes	orthologues
T12861	16170-16172	IN	denotes	on
T12862	16173-16176	DT	denotes	the
T12863	16189-16192	NN	denotes	arm
T12864	16177-16183	JJ	denotes	distal
T12865	16184-16188	JJ	denotes	long
T12866	16193-16195	IN	denotes	of
T12867	16196-16201	JJ	denotes	human
T12868	16220-16224	NN	denotes	4p16
T12869	16202-16212	NN	denotes	chromosome
T12870	16213-16215	CD	denotes	10
T12871	16216-16219	CC	denotes	and
T12872	16224-16225	.	denotes	.
T12873	16225-16359	sentence	denotes	This scaffold, therefore, has some of the characteristics of the predicted immediate ancestor of the TACC1/TACC2 chromosomal segment.
T12874	16226-16230	DT	denotes	This
T12875	16231-16239	NN	denotes	scaffold
T12876	16252-16255	VBZ	denotes	has
T12877	16239-16241	,	denotes	,
T12878	16241-16250	RB	denotes	therefore
T12879	16250-16252	,	denotes	,
T12880	16256-16260	DT	denotes	some
T12881	16261-16263	IN	denotes	of
T12882	16264-16267	DT	denotes	the
T12883	16268-16283	NNS	denotes	characteristics
T12884	16284-16286	IN	denotes	of
T12885	16287-16290	DT	denotes	the
T12886	16311-16319	NN	denotes	ancestor
T12887	16291-16300	VBN	denotes	predicted
T12888	16301-16310	JJ	denotes	immediate
T12889	16320-16322	IN	denotes	of
T12890	16323-16326	DT	denotes	the
T12891	16351-16358	NN	denotes	segment
T12892	16327-16332	NN	denotes	TACC1
T12893	16333-16338	NN	denotes	TACC2
T12894	16332-16333	HYPH	denotes	/
T12895	16339-16350	JJ	denotes	chromosomal
T12896	16358-16359	.	denotes	.
T12897	16359-16485	sentence	denotes	trTACC1B is found on scaffold 191, which contains orthologues of genes found in the proximal short arm of human chromosome 8.
T12898	16360-16368	NN	denotes	trTACC1B
T12899	16372-16377	VBN	denotes	found
T12900	16369-16371	VBZ	denotes	is
T12901	16378-16380	IN	denotes	on
T12902	16381-16389	NN	denotes	scaffold
T12903	16390-16393	CD	denotes	191
T12904	16393-16395	,	denotes	,
T12905	16395-16400	WDT	denotes	which
T12906	16401-16409	VBZ	denotes	contains
T12907	16410-16421	NNS	denotes	orthologues
T12908	16422-16424	IN	denotes	of
T12909	16425-16430	NNS	denotes	genes
T12910	16431-16436	VBN	denotes	found
T12911	16437-16439	IN	denotes	in
T12912	16440-16443	DT	denotes	the
T12913	16459-16462	NN	denotes	arm
T12914	16444-16452	JJ	denotes	proximal
T12915	16453-16458	JJ	denotes	short
T12916	16463-16465	IN	denotes	of
T12917	16466-16471	JJ	denotes	human
T12918	16472-16482	NN	denotes	chromosome
T12919	16483-16484	CD	denotes	8
T12920	16484-16485	.	denotes	.
T12921	16485-16594	sentence	denotes	(B): Ciona intestinalis clusters containing genes found in paralogous segments on human 8, 4p16, 10q and 5q.
T12922	16486-16487	-LRB-	denotes	(
T12923	16487-16488	LS	denotes	B
T12924	16510-16518	NNS	denotes	clusters
T12925	16488-16489	-RRB-	denotes	)
T12926	16489-16491	:	denotes	:
T12927	16491-16496	NNP	denotes	Ciona
T12928	16497-16509	NNP	denotes	intestinalis
T12929	16519-16529	VBG	denotes	containing
T12930	16530-16535	NNS	denotes	genes
T12931	16536-16541	VBN	denotes	found
T12932	16542-16544	IN	denotes	in
T12933	16545-16555	JJ	denotes	paralogous
T12934	16556-16564	NNS	denotes	segments
T12935	16565-16567	IN	denotes	on
T12936	16568-16573	JJ	denotes	human
T12937	16577-16581	NN	denotes	4p16
T12938	16574-16575	CD	denotes	8
T12939	16575-16577	,	denotes	,
T12940	16581-16583	,	denotes	,
T12941	16583-16586	NN	denotes	10q
T12942	16587-16590	CC	denotes	and
T12943	16591-16593	NN	denotes	5q
T12944	16593-16594	.	denotes	.
T12994	16605-16612	JJ	denotes	Genomic
T12995	16613-16622	NN	denotes	structure
T12996	16623-16625	IN	denotes	of
T12997	16626-16629	DT	denotes	the
T12998	16635-16640	NNS	denotes	genes
T12999	16630-16634	NN	denotes	TACC
T13000	16640-16641	.	denotes	.
T13001	16641-16727	sentence	denotes	Conserved regions known to bind protein factors in all human TACC proteins are shown.
T13002	16642-16651	VBN	denotes	Conserved
T13003	16652-16659	NNS	denotes	regions
T13004	16721-16726	VBN	denotes	shown
T13005	16660-16665	VBN	denotes	known
T13006	16666-16668	TO	denotes	to
T13007	16669-16673	VB	denotes	bind
T13008	16674-16681	NN	denotes	protein
T13009	16682-16689	NNS	denotes	factors
T13010	16690-16692	IN	denotes	in
T13011	16693-16696	DT	denotes	all
T13012	16708-16716	NN	denotes	proteins
T13013	16697-16702	JJ	denotes	human
T13014	16703-16707	NN	denotes	TACC
T13015	16717-16720	VBP	denotes	are
T13016	16726-16727	.	denotes	.
T13017	16727-16811	sentence	denotes	The SDP repeat of human TACC1-3 is known to bind GAS41 ([3,15] and data not shown).
T13018	16728-16731	DT	denotes	The
T13019	16736-16742	NN	denotes	repeat
T13020	16732-16735	NN	denotes	SDP
T13021	16763-16768	VBN	denotes	known
T13022	16743-16745	IN	denotes	of
T13023	16746-16751	JJ	denotes	human
T13024	16752-16757	NN	denotes	TACC1
T13025	16757-16758	HYPH	denotes	-
T13026	16758-16759	CD	denotes	3
T13027	16760-16762	VBZ	denotes	is
T13028	16769-16771	TO	denotes	to
T13029	16772-16776	VB	denotes	bind
T13030	16777-16782	NN	denotes	GAS41
T13031	16783-16784	-LRB-	denotes	(
T13032	16787-16789	CD	denotes	15
T13033	16784-16785	-LRB-	denotes	[
T13034	16785-16786	CD	denotes	3
T13035	16786-16787	,	denotes	,
T13036	16789-16790	-RRB-	denotes	]
T13037	16791-16794	CC	denotes	and
T13038	16795-16799	NNS	denotes	data
T13039	16804-16809	VBN	denotes	shown
T13040	16800-16803	RB	denotes	not
T13041	16809-16810	-RRB-	denotes	)
T13042	16810-16811	.	denotes	.
T13043	16811-16907	sentence	denotes	The TACC domain binds ch-TOG and members of the Aurora kinases in all species examined to date.
T13044	16812-16815	DT	denotes	The
T13045	16821-16827	NN	denotes	domain
T13046	16816-16820	NN	denotes	TACC
T13047	16828-16833	VBZ	denotes	binds
T13048	16834-16836	NN	denotes	ch
T13049	16837-16840	NN	denotes	TOG
T13050	16836-16837	HYPH	denotes	-
T13051	16841-16844	CC	denotes	and
T13052	16845-16852	NNS	denotes	members
T13053	16853-16855	IN	denotes	of
T13054	16856-16859	DT	denotes	the
T13055	16867-16874	NNS	denotes	kinases
T13056	16860-16866	NNP	denotes	Aurora
T13057	16875-16877	IN	denotes	in
T13058	16878-16881	DT	denotes	all
T13059	16882-16889	NNS	denotes	species
T13060	16890-16898	VBN	denotes	examined
T13061	16899-16901	IN	denotes	to
T13062	16902-16906	NN	denotes	date
T13063	16906-16907	.	denotes	.
T13064	16907-16983	sentence	denotes	This motif is characteristically encoded by the 3' exons of the TACC genes.
T13065	16908-16912	DT	denotes	This
T13066	16913-16918	NN	denotes	motif
T13067	16941-16948	VBN	denotes	encoded
T13068	16919-16921	VBZ	denotes	is
T13069	16922-16940	RB	denotes	characteristically
T13070	16949-16951	IN	denotes	by
T13071	16952-16955	DT	denotes	the
T13072	16959-16964	NNS	denotes	exons
T13073	16956-16957	CD	denotes	3
T13074	16957-16958	SYM	denotes	'
T13075	16965-16967	IN	denotes	of
T13076	16968-16971	DT	denotes	the
T13077	16977-16982	NNS	denotes	genes
T13078	16972-16976	NN	denotes	TACC
T13079	16982-16983	.	denotes	.
T13080	16983-17039	sentence	denotes	The size of the largest isoform for each gene is shown.
T13081	16984-16987	DT	denotes	The
T13082	16988-16992	NN	denotes	size
T13083	17033-17038	VBN	denotes	shown
T13084	16993-16995	IN	denotes	of
T13085	16996-16999	DT	denotes	the
T13086	17008-17015	NN	denotes	isoform
T13087	17000-17007	JJS	denotes	largest
T13088	17016-17019	IN	denotes	for
T13089	17020-17024	DT	denotes	each
T13090	17025-17029	NN	denotes	gene
T13091	17030-17032	VBZ	denotes	is
T13092	17038-17039	.	denotes	.
T13211	22576-22587	JJ	denotes	Alternative
T13212	22588-22596	NN	denotes	splicing
T13213	22597-22599	IN	denotes	of
T13214	22600-22603	DT	denotes	the
T13215	22616-22620	NN	denotes	gene
T13216	22604-22609	JJ	denotes	human
T13217	22610-22615	NN	denotes	TACC1
T13218	22620-22621	.	denotes	.
T13219	22621-22698	sentence	denotes	(A): Seven splice variants have been identified for human TACC1 (A-F and S).
T13220	22622-22623	-LRB-	denotes	(
T13221	22623-22624	LS	denotes	A
T13222	22659-22669	VBN	denotes	identified
T13223	22624-22625	-RRB-	denotes	)
T13224	22625-22627	:	denotes	:
T13225	22627-22632	CD	denotes	Seven
T13226	22640-22648	NNS	denotes	variants
T13227	22633-22639	NN	denotes	splice
T13228	22649-22653	VBP	denotes	have
T13229	22654-22658	VBN	denotes	been
T13230	22670-22673	IN	denotes	for
T13231	22674-22679	JJ	denotes	human
T13232	22680-22685	NN	denotes	TACC1
T13233	22686-22687	-LRB-	denotes	(
T13234	22687-22688	NN	denotes	A
T13235	22688-22689	SYM	denotes	-
T13236	22689-22690	NN	denotes	F
T13237	22691-22694	CC	denotes	and
T13238	22695-22696	NN	denotes	S
T13239	22696-22697	-RRB-	denotes	)
T13240	22697-22698	.	denotes	.
T13241	22698-22818	sentence	denotes	We have also identified additional splice variants (G-I) from database analysis and rt-PCR analysis of human brain RNA.
T13242	22699-22701	PRP	denotes	We
T13243	22712-22722	VBN	denotes	identified
T13244	22702-22706	VBP	denotes	have
T13245	22707-22711	RB	denotes	also
T13246	22723-22733	JJ	denotes	additional
T13247	22741-22749	NNS	denotes	variants
T13248	22734-22740	NN	denotes	splice
T13249	22750-22751	-LRB-	denotes	(
T13250	22751-22752	NN	denotes	G
T13251	22752-22753	SYM	denotes	-
T13252	22753-22754	NN	denotes	I
T13253	22754-22755	-RRB-	denotes	)
T13254	22756-22760	IN	denotes	from
T13255	22761-22769	NN	denotes	database
T13256	22770-22778	NN	denotes	analysis
T13257	22779-22782	CC	denotes	and
T13258	22783-22785	NN	denotes	rt
T13259	22786-22789	NN	denotes	PCR
T13260	22785-22786	HYPH	denotes	-
T13261	22790-22798	NN	denotes	analysis
T13262	22799-22801	IN	denotes	of
T13263	22802-22807	JJ	denotes	human
T13264	22808-22813	NN	denotes	brain
T13265	22814-22817	NN	denotes	RNA
T13266	22817-22818	.	denotes	.
T13267	22818-22873	sentence	denotes	(B): Alternative splicing of TACC1 in the human brain.
T13268	22819-22820	-LRB-	denotes	(
T13269	22820-22821	LS	denotes	B
T13270	22836-22844	NN	denotes	splicing
T13271	22821-22822	-RRB-	denotes	)
T13272	22822-22824	:	denotes	:
T13273	22824-22835	JJ	denotes	Alternative
T13274	22845-22847	IN	denotes	of
T13275	22848-22853	NN	denotes	TACC1
T13276	22854-22856	IN	denotes	in
T13277	22857-22860	DT	denotes	the
T13278	22867-22872	NN	denotes	brain
T13279	22861-22866	JJ	denotes	human
T13280	22872-22873	.	denotes	.
T13281	22873-23048	sentence	denotes	rt-PCR analysis confirms splicing of the untranslated exon 1a to exon 1, with retention of the originally defined start methionine (GB:NP_006274) (Variant A*, lanes 1 and 3).
T13282	22874-22876	NN	denotes	rt
T13283	22877-22880	NN	denotes	PCR
T13284	22876-22877	HYPH	denotes	-
T13285	22881-22889	NN	denotes	analysis
T13286	22890-22898	VBZ	denotes	confirms
T13287	22899-22907	NN	denotes	splicing
T13288	22908-22910	IN	denotes	of
T13289	22911-22914	DT	denotes	the
T13290	22928-22932	NN	denotes	exon
T13291	22915-22927	JJ	denotes	untranslated
T13292	22933-22935	CD	denotes	1a
T13293	22936-22938	IN	denotes	to
T13294	22939-22943	NN	denotes	exon
T13295	22944-22945	CD	denotes	1
T13296	22945-22947	,	denotes	,
T13297	22947-22951	IN	denotes	with
T13298	22952-22961	NN	denotes	retention
T13299	22962-22964	IN	denotes	of
T13300	22965-22968	DT	denotes	the
T13301	22994-23004	NN	denotes	methionine
T13302	22969-22979	RB	denotes	originally
T13303	22980-22987	VBN	denotes	defined
T13304	22988-22993	NN	denotes	start
T13305	23005-23006	-LRB-	denotes	(
T13306	23009-23018	NN	denotes	NP_006274
T13307	23006-23008	NN	denotes	GB
T13308	23008-23009	:	denotes	:
T13309	23018-23019	-RRB-	denotes	)
T13310	23020-23021	-LRB-	denotes	(
T13311	23039-23040	CD	denotes	1
T13312	23021-23028	NN	denotes	Variant
T13313	23029-23030	NN	denotes	A
T13314	23030-23031	SYM	denotes	*
T13315	23031-23033	,	denotes	,
T13316	23033-23038	NNS	denotes	lanes
T13317	23041-23044	CC	denotes	and
T13318	23045-23046	CD	denotes	3
T13319	23046-23047	-RRB-	denotes	)
T13320	23047-23048	.	denotes	.
T13321	23048-23145	sentence	denotes	Exon 1a also splices to exon 2, removing the L-Sm7 binding motif (variant I, lanes 3,12 and 13).
T13322	23049-23053	NN	denotes	Exon
T13323	23062-23069	VBZ	denotes	splices
T13324	23054-23056	CD	denotes	1a
T13325	23057-23061	RB	denotes	also
T13326	23070-23072	IN	denotes	to
T13327	23073-23077	NN	denotes	exon
T13328	23078-23079	CD	denotes	2
T13329	23079-23081	,	denotes	,
T13330	23081-23089	VBG	denotes	removing
T13331	23090-23093	DT	denotes	the
T13332	23108-23113	NN	denotes	motif
T13333	23094-23095	NN	denotes	L
T13334	23096-23099	NN	denotes	Sm7
T13335	23095-23096	HYPH	denotes	-
T13336	23100-23107	NN	denotes	binding
T13337	23114-23115	-LRB-	denotes	(
T13338	23132-23133	CD	denotes	3
T13339	23115-23122	NN	denotes	variant
T13340	23123-23124	NN	denotes	I
T13341	23124-23126	,	denotes	,
T13342	23126-23131	NNS	denotes	lanes
T13343	23133-23134	,	denotes	,
T13344	23134-23136	CD	denotes	12
T13345	23137-23140	CC	denotes	and
T13346	23141-23143	CD	denotes	13
T13347	23143-23144	-RRB-	denotes	)
T13348	23144-23145	.	denotes	.
T13349	23145-23331	sentence	denotes	Variants that functionally delete exons 2 and/or 3, such as variant C (lane 15) also remove the predicted nuclear localization signals, and the binding domains for GAS41 and PCTAIRE2BP.
T13350	23146-23154	NNS	denotes	Variants
T13351	23231-23237	VBP	denotes	remove
T13352	23155-23159	WDT	denotes	that
T13353	23173-23179	VBP	denotes	delete
T13354	23160-23172	RB	denotes	functionally
T13355	23180-23185	NNS	denotes	exons
T13356	23186-23187	CD	denotes	2
T13357	23188-23191	CC	denotes	and
T13358	23191-23192	HYPH	denotes	/
T13359	23192-23194	CC	denotes	or
T13360	23195-23196	CD	denotes	3
T13361	23196-23198	,	denotes	,
T13362	23198-23202	JJ	denotes	such
T13363	23203-23205	IN	denotes	as
T13364	23206-23213	NN	denotes	variant
T13365	23214-23215	NN	denotes	C
T13366	23216-23217	-LRB-	denotes	(
T13367	23217-23221	NN	denotes	lane
T13368	23222-23224	CD	denotes	15
T13369	23224-23225	-RRB-	denotes	)
T13370	23226-23230	RB	denotes	also
T13371	23238-23241	DT	denotes	the
T13372	23273-23280	NNS	denotes	signals
T13373	23242-23251	VBN	denotes	predicted
T13374	23252-23259	JJ	denotes	nuclear
T13375	23260-23272	NN	denotes	localization
T13376	23280-23282	,	denotes	,
T13377	23282-23285	CC	denotes	and
T13378	23286-23289	DT	denotes	the
T13379	23298-23305	NNS	denotes	domains
T13380	23290-23297	NN	denotes	binding
T13381	23306-23309	IN	denotes	for
T13382	23310-23315	NN	denotes	GAS41
T13383	23316-23319	CC	denotes	and
T13384	23320-23330	NN	denotes	PCTAIRE2BP
T13385	23330-23331	.	denotes	.
T13386	23331-23461	sentence	denotes	These variants would retain the TACC domain, and therefore the potential to bind to ch-TOG and Aurora A kinase in the centrosome.
T13387	23332-23337	DT	denotes	These
T13388	23338-23346	NNS	denotes	variants
T13389	23353-23359	VB	denotes	retain
T13390	23347-23352	MD	denotes	would
T13391	23360-23363	DT	denotes	the
T13392	23369-23375	NN	denotes	domain
T13393	23364-23368	NN	denotes	TACC
T13394	23375-23377	,	denotes	,
T13395	23377-23380	CC	denotes	and
T13396	23381-23390	RB	denotes	therefore
T13397	23395-23404	NN	denotes	potential
T13398	23391-23394	DT	denotes	the
T13399	23405-23407	TO	denotes	to
T13400	23408-23412	VB	denotes	bind
T13401	23413-23415	IN	denotes	to
T13402	23416-23418	NN	denotes	ch
T13403	23419-23422	NN	denotes	TOG
T13404	23418-23419	HYPH	denotes	-
T13405	23423-23426	CC	denotes	and
T13406	23427-23433	NN	denotes	Aurora
T13407	23434-23435	NN	denotes	A
T13408	23436-23442	NN	denotes	kinase
T13409	23443-23445	IN	denotes	in
T13410	23446-23449	DT	denotes	the
T13411	23450-23460	NN	denotes	centrosome
T13412	23460-23461	.	denotes	.
T13413	23461-23766	sentence	denotes	Lane 1: EF/X1R, Lane 2: EF/BX647R, Lane 3: EF/6SPR, Lane 4: EF/1DR, Lane 5, EF/128R, Lane 6 X3F/X1R, Lane 7: X3F/BX647R, Lane 8: X3F/6SPR, Lane 9: X3F/1DR, Lane 10, X3F/128R, Lane 11: 1DF/X1R, Lane 12: 1DF/BX647R, Lane 13: 1DF/6SPR, Lane 14: 1DF/1DR, Lane 15: 1DF/128R, Lane 16: Biorad 1 kb+ Size ladder.
T13414	23462-23466	NN	denotes	Lane
T13415	23473-23476	NN	denotes	X1R
T13416	23467-23468	CD	denotes	1
T13417	23468-23470	:	denotes	:
T13418	23470-23472	NN	denotes	EF
T13419	23472-23473	HYPH	denotes	/
T13420	23759-23765	NN	denotes	ladder
T13421	23476-23478	,	denotes	,
T13422	23478-23482	NN	denotes	Lane
T13423	23489-23495	NN	denotes	BX647R
T13424	23483-23484	CD	denotes	2
T13425	23484-23486	:	denotes	:
T13426	23486-23488	NN	denotes	EF
T13427	23488-23489	HYPH	denotes	/
T13428	23495-23497	,	denotes	,
T13429	23497-23501	NN	denotes	Lane
T13430	23508-23512	NN	denotes	6SPR
T13431	23502-23503	CD	denotes	3
T13432	23503-23505	:	denotes	:
T13433	23505-23507	NN	denotes	EF
T13434	23507-23508	HYPH	denotes	/
T13435	23512-23514	,	denotes	,
T13436	23514-23518	NN	denotes	Lane
T13437	23525-23528	NN	denotes	1DR
T13438	23519-23520	CD	denotes	4
T13439	23520-23522	:	denotes	:
T13440	23522-23524	NN	denotes	EF
T13441	23524-23525	HYPH	denotes	/
T13442	23528-23530	,	denotes	,
T13443	23530-23534	NN	denotes	Lane
T13444	23541-23545	NN	denotes	128R
T13445	23535-23536	CD	denotes	5
T13446	23536-23538	,	denotes	,
T13447	23538-23540	NN	denotes	EF
T13448	23540-23541	HYPH	denotes	/
T13449	23545-23547	,	denotes	,
T13450	23547-23551	NN	denotes	Lane
T13451	23558-23561	NN	denotes	X1R
T13452	23552-23553	CD	denotes	6
T13453	23554-23557	NN	denotes	X3F
T13454	23557-23558	HYPH	denotes	/
T13455	23561-23563	,	denotes	,
T13456	23563-23567	NN	denotes	Lane
T13457	23575-23581	NN	denotes	BX647R
T13458	23568-23569	CD	denotes	7
T13459	23569-23571	:	denotes	:
T13460	23571-23574	NN	denotes	X3F
T13461	23574-23575	HYPH	denotes	/
T13462	23581-23583	,	denotes	,
T13463	23583-23587	NN	denotes	Lane
T13464	23595-23599	NN	denotes	6SPR
T13465	23588-23589	CD	denotes	8
T13466	23589-23591	:	denotes	:
T13467	23591-23594	NN	denotes	X3F
T13468	23594-23595	HYPH	denotes	/
T13469	23599-23601	,	denotes	,
T13470	23601-23605	NN	denotes	Lane
T13471	23613-23616	NN	denotes	1DR
T13472	23606-23607	CD	denotes	9
T13473	23607-23609	:	denotes	:
T13474	23609-23612	NN	denotes	X3F
T13475	23612-23613	HYPH	denotes	/
T13476	23616-23618	,	denotes	,
T13477	23618-23622	NN	denotes	Lane
T13478	23631-23635	NN	denotes	128R
T13479	23623-23625	CD	denotes	10
T13480	23625-23627	,	denotes	,
T13481	23627-23630	NN	denotes	X3F
T13482	23630-23631	HYPH	denotes	/
T13483	23635-23637	,	denotes	,
T13484	23637-23641	NN	denotes	Lane
T13485	23650-23653	NN	denotes	X1R
T13486	23642-23644	CD	denotes	11
T13487	23644-23646	:	denotes	:
T13488	23646-23649	NN	denotes	1DF
T13489	23649-23650	HYPH	denotes	/
T13490	23653-23655	,	denotes	,
T13491	23655-23659	NN	denotes	Lane
T13492	23668-23674	NN	denotes	BX647R
T13493	23660-23662	CD	denotes	12
T13494	23662-23664	:	denotes	:
T13495	23664-23667	NN	denotes	1DF
T13496	23667-23668	HYPH	denotes	/
T13497	23674-23676	,	denotes	,
T13498	23676-23680	NN	denotes	Lane
T13499	23689-23693	NN	denotes	6SPR
T13500	23681-23683	CD	denotes	13
T13501	23683-23685	:	denotes	:
T13502	23685-23688	NN	denotes	1DF
T13503	23688-23689	HYPH	denotes	/
T13504	23693-23695	,	denotes	,
T13505	23695-23699	NN	denotes	Lane
T13506	23708-23711	NN	denotes	1DR
T13507	23700-23702	CD	denotes	14
T13508	23702-23704	:	denotes	:
T13509	23704-23707	NN	denotes	1DF
T13510	23707-23708	HYPH	denotes	/
T13511	23711-23713	,	denotes	,
T13512	23713-23717	NN	denotes	Lane
T13513	23726-23730	NN	denotes	128R
T13514	23718-23720	CD	denotes	15
T13515	23720-23722	:	denotes	:
T13516	23722-23725	NN	denotes	1DF
T13517	23725-23726	HYPH	denotes	/
T13518	23730-23732	,	denotes	,
T13519	23732-23736	NN	denotes	Lane
T13520	23737-23739	CD	denotes	16
T13521	23739-23741	:	denotes	:
T13522	23741-23747	NNP	denotes	Biorad
T13523	23748-23749	CD	denotes	1
T13524	23750-23753	NN	denotes	kb+
T13525	23754-23758	NN	denotes	Size
T13526	23765-23766	.	denotes	.
T13617	26915-26925	JJ	denotes	Functional
T13618	26926-26935	NN	denotes	evolution
T13619	26936-26938	IN	denotes	of
T13620	26939-26942	DT	denotes	the
T13621	26948-26956	NN	denotes	proteins
T13622	26943-26947	NN	denotes	TACC
T13623	26957-26964	VBN	denotes	modeled
T13624	26965-26967	IN	denotes	in
T13625	26968-26970	NNP	denotes	C.
T13626	26971-26978	NNP	denotes	elegans
T13627	26979-26982	CC	denotes	and
T13628	26983-26985	NNP	denotes	D.
T13629	26986-26998	NNP	denotes	melanogaster
T13630	26998-26999	.	denotes	.
T13631	26999-27127	sentence	denotes	(A). C. elegans interaction map shows empirically defined interactions of ceTAC, and extrapolated interactions defined by [28].
T13632	27000-27001	-LRB-	denotes	(
T13633	27001-27002	LS	denotes	A
T13634	27032-27037	VBZ	denotes	shows
T13635	27002-27003	-RRB-	denotes	)
T13636	27003-27004	.	denotes	.
T13637	27005-27007	NNP	denotes	C.
T13638	27008-27015	NNP	denotes	elegans
T13639	27028-27031	NN	denotes	map
T13640	27016-27027	NN	denotes	interaction
T13641	27038-27049	RB	denotes	empirically
T13642	27050-27057	VBN	denotes	defined
T13643	27058-27070	NNS	denotes	interactions
T13644	27071-27073	IN	denotes	of
T13645	27074-27079	NN	denotes	ceTAC
T13646	27079-27081	,	denotes	,
T13647	27081-27084	CC	denotes	and
T13648	27085-27097	VBN	denotes	extrapolated
T13649	27098-27110	NNS	denotes	interactions
T13650	27111-27118	VBN	denotes	defined
T13651	27119-27121	IN	denotes	by
T13652	27122-27123	-LRB-	denotes	[
T13653	27123-27125	CD	denotes	28
T13654	27125-27126	-RRB-	denotes	]
T13655	27126-27127	.	denotes	.
T13656	27127-27398	sentence	denotes	(B): Using the BIND database [29], DTACC directly binds to TBPH and CG14540, and thus indirectly to chromatin remodeling complexes (SWI/SNF and histone acetyltransferases), DNA damage repair machinery (via RAD23), and RNA splicing, transport and translational machinery.
T13657	27128-27129	-LRB-	denotes	(
T13658	27129-27130	LS	denotes	B
T13659	27178-27183	VBZ	denotes	binds
T13660	27130-27131	-RRB-	denotes	)
T13661	27131-27133	:	denotes	:
T13662	27133-27138	VBG	denotes	Using
T13663	27139-27142	DT	denotes	the
T13664	27148-27156	NN	denotes	database
T13665	27143-27147	NNP	denotes	BIND
T13666	27157-27158	-LRB-	denotes	[
T13667	27158-27160	CD	denotes	29
T13668	27160-27161	-RRB-	denotes	]
T13669	27161-27163	,	denotes	,
T13670	27163-27168	NN	denotes	DTACC
T13671	27169-27177	RB	denotes	directly
T13672	27184-27186	IN	denotes	to
T13673	27187-27191	NN	denotes	TBPH
T13674	27192-27195	CC	denotes	and
T13675	27196-27203	NN	denotes	CG14540
T13676	27203-27205	,	denotes	,
T13677	27205-27208	CC	denotes	and
T13678	27209-27213	RB	denotes	thus
T13679	27214-27224	RB	denotes	indirectly
T13680	27225-27227	IN	denotes	to
T13681	27228-27237	NN	denotes	chromatin
T13682	27238-27248	NN	denotes	remodeling
T13683	27249-27258	NNS	denotes	complexes
T13684	27259-27260	-LRB-	denotes	(
T13685	27260-27263	NN	denotes	SWI
T13686	27264-27267	NN	denotes	SNF
T13687	27263-27264	HYPH	denotes	/
T13688	27268-27271	CC	denotes	and
T13689	27272-27279	NN	denotes	histone
T13690	27280-27298	NNS	denotes	acetyltransferases
T13691	27298-27299	-RRB-	denotes	)
T13692	27299-27301	,	denotes	,
T13693	27301-27304	NN	denotes	DNA
T13694	27305-27311	NN	denotes	damage
T13695	27312-27318	NN	denotes	repair
T13696	27319-27328	NN	denotes	machinery
T13697	27329-27330	-LRB-	denotes	(
T13698	27330-27333	IN	denotes	via
T13699	27334-27339	NN	denotes	RAD23
T13700	27339-27340	-RRB-	denotes	)
T13701	27340-27342	,	denotes	,
T13702	27342-27345	CC	denotes	and
T13703	27346-27349	NN	denotes	RNA
T13704	27350-27358	NN	denotes	splicing
T13705	27388-27397	NN	denotes	machinery
T13706	27358-27360	,	denotes	,
T13707	27360-27369	NN	denotes	transport
T13708	27370-27373	CC	denotes	and
T13709	27374-27387	JJ	denotes	translational
T13710	27397-27398	.	denotes	.
T13711	27398-27542	sentence	denotes	(C): Predicted interaction map for vertebrate TACCs, based upon ceTAC, suggests an indirect interaction with the nuclear hormone receptor RXRβ.
T13712	27399-27400	-LRB-	denotes	(
T13713	27400-27401	LS	denotes	C
T13714	27470-27478	VBZ	denotes	suggests
T13715	27401-27402	-RRB-	denotes	)
T13716	27402-27404	:	denotes	:
T13717	27404-27413	VBN	denotes	Predicted
T13718	27414-27425	NN	denotes	interaction
T13719	27426-27429	NN	denotes	map
T13720	27430-27433	IN	denotes	for
T13721	27434-27444	NN	denotes	vertebrate
T13722	27445-27450	NNS	denotes	TACCs
T13723	27450-27452	,	denotes	,
T13724	27452-27457	VBN	denotes	based
T13725	27458-27462	IN	denotes	upon
T13726	27463-27468	NN	denotes	ceTAC
T13727	27468-27470	,	denotes	,
T13728	27479-27481	DT	denotes	an
T13729	27491-27502	NN	denotes	interaction
T13730	27482-27490	JJ	denotes	indirect
T13731	27503-27507	IN	denotes	with
T13732	27508-27511	DT	denotes	the
T13733	27528-27536	NN	denotes	receptor
T13734	27512-27519	JJ	denotes	nuclear
T13735	27520-27527	NN	denotes	hormone
T13736	27537-27541	NN	denotes	RXRβ
T13737	27541-27542	.	denotes	.
T13738	27542-27743	sentence	denotes	It is also of interest that this predicts a functional interaction with the LDB family, members of which are also found in TACC containing paralogous segments noted in Figs 2, 3 and Additional file 1.
T13739	27543-27545	PRP	denotes	It
T13740	27546-27548	VBZ	denotes	is
T13741	27549-27553	RB	denotes	also
T13742	27554-27556	IN	denotes	of
T13743	27557-27565	NN	denotes	interest
T13744	27566-27570	IN	denotes	that
T13745	27576-27584	VBZ	denotes	predicts
T13746	27571-27575	DT	denotes	this
T13747	27585-27586	DT	denotes	a
T13748	27598-27609	NN	denotes	interaction
T13749	27587-27597	JJ	denotes	functional
T13750	27610-27614	IN	denotes	with
T13751	27615-27618	DT	denotes	the
T13752	27623-27629	NN	denotes	family
T13753	27619-27622	NN	denotes	LDB
T13754	27629-27631	,	denotes	,
T13755	27631-27638	NNS	denotes	members
T13756	27657-27662	VBN	denotes	found
T13757	27639-27641	IN	denotes	of
T13758	27642-27647	WDT	denotes	which
T13759	27648-27651	VBP	denotes	are
T13760	27652-27656	RB	denotes	also
T13761	27663-27665	IN	denotes	in
T13762	27666-27670	NN	denotes	TACC
T13763	27671-27681	VBG	denotes	containing
T13764	27693-27701	NNS	denotes	segments
T13765	27682-27692	JJ	denotes	paralogous
T13766	27702-27707	VBN	denotes	noted
T13767	27708-27710	IN	denotes	in
T13768	27711-27715	NNS	denotes	Figs
T13769	27719-27720	CD	denotes	3
T13770	27716-27717	CD	denotes	2
T13771	27717-27719	,	denotes	,
T13772	27721-27724	CC	denotes	and
T13773	27725-27735	JJ	denotes	Additional
T13774	27736-27740	NN	denotes	file
T13775	27741-27742	CD	denotes	1
T13776	27742-27743	.	denotes	.
T13777	27743-27797	sentence	denotes	(D): Predicted TACC interaction map based upon DTACC.
T13778	27744-27745	-LRB-	denotes	(
T13779	27745-27746	LS	denotes	D
T13780	27776-27779	NN	denotes	map
T13781	27746-27747	-RRB-	denotes	)
T13782	27747-27749	:	denotes	:
T13783	27749-27758	VBN	denotes	Predicted
T13784	27759-27763	NN	denotes	TACC
T13785	27764-27775	NN	denotes	interaction
T13786	27780-27785	VBN	denotes	based
T13787	27786-27790	IN	denotes	upon
T13788	27791-27796	NN	denotes	DTACC
T13789	27796-27797	.	denotes	.
T13790	27797-27851	sentence	denotes	(E): Vertebrate TACC interactions identified to date.
T13791	27798-27799	-LRB-	denotes	(
T13792	27799-27800	LS	denotes	E
T13793	27819-27831	NNS	denotes	interactions
T13794	27800-27801	-RRB-	denotes	)
T13795	27801-27803	:	denotes	:
T13796	27803-27813	NN	denotes	Vertebrate
T13797	27814-27818	NN	denotes	TACC
T13798	27832-27842	VBN	denotes	identified
T13799	27843-27845	IN	denotes	to
T13800	27846-27850	NN	denotes	date
T13801	27850-27851	.	denotes	.
T13802	27851-27929	sentence	denotes	? denotes uncertainty over the identity of a functional vertebrate homologue.
T13803	27852-27853	SYM	denotes	?
T13804	27854-27861	VBZ	denotes	denotes
T13805	27862-27873	NN	denotes	uncertainty
T13806	27874-27878	IN	denotes	over
T13807	27879-27882	DT	denotes	the
T13808	27883-27891	NN	denotes	identity
T13809	27892-27894	IN	denotes	of
T13810	27895-27896	DT	denotes	a
T13811	27919-27928	NN	denotes	homologue
T13812	27897-27907	JJ	denotes	functional
T13813	27908-27918	NN	denotes	vertebrate
T13818	27933-27934	NN	denotes	C
T13819	27934-27936	,	denotes	,
T13820	27936-27937	NN	denotes	D
T13821	27938-27941	CC	denotes	and
T13822	27942-27943	NN	denotes	E
T13823	27943-27945	,	denotes	,
T13824	27945-27946	``	denotes	'
T13825	27947-27948	''	denotes	'
T13826	27946-27947	SYM	denotes	*
T13827	27957-27960	CD	denotes	one
T13828	27969-27976	NNS	denotes	members
T13829	27961-27963	CC	denotes	or
T13830	27964-27968	JJR	denotes	more
T13831	27977-27979	IN	denotes	of
T13832	27980-27983	DT	denotes	the
T13833	28006-28012	NN	denotes	family
T13834	27984-27988	NN	denotes	TACC
T13835	27989-27991	CC	denotes	or
T13836	27992-27998	NN	denotes	Aurora
T13837	27999-28005	NN	denotes	kinase
T13838	28012-28013	.	denotes	.
T13918	33720-33724	NN	denotes	Lane
T13919	33725-33726	CD	denotes	3
T13920	33726-33728	SYM	denotes	:
T13921	33728-33729	CD	denotes	5
T13922	33729-33730	NN	denotes	%
T13923	33737-33739	IN	denotes	of
T13924	33740-33742	FW	denotes	in
T13925	33743-33748	FW	denotes	vitro
T13926	33766-33773	NN	denotes	protein
T13927	33749-33759	VBN	denotes	translated
T13928	33760-33763	NN	denotes	RXR
T13929	33764-33765	NN	denotes	β
T13930	33763-33764	HYPH	denotes	-
T13931	33773-33774	.	denotes	.
T13932	33774-33892	sentence	denotes	Bottom two panels represent Coomassie blue stained gels of pull down experiment showing loading of GST-TACC2 and GST.
T13933	33775-33781	JJ	denotes	Bottom
T13934	33786-33792	NNS	denotes	panels
T13935	33782-33785	CD	denotes	two
T13936	33793-33802	VBP	denotes	represent
T13937	33803-33812	NNP	denotes	Coomassie
T13938	33826-33830	NNS	denotes	gels
T13939	33813-33817	JJ	denotes	blue
T13940	33818-33825	VBN	denotes	stained
T13941	33831-33833	IN	denotes	of
T13942	33834-33838	VB	denotes	pull
T13943	33844-33854	NN	denotes	experiment
T13944	33839-33843	RP	denotes	down
T13945	33855-33862	VBG	denotes	showing
T13946	33863-33870	NN	denotes	loading
T13947	33871-33873	IN	denotes	of
T13948	33874-33877	NN	denotes	GST
T13949	33878-33883	NN	denotes	TACC2
T13950	33877-33878	HYPH	denotes	-
T13951	33884-33887	CC	denotes	and
T13952	33888-33891	NN	denotes	GST
T13953	33891-33892	.	denotes	.
T13889	33596-33598	IN	denotes	of
T13890	33599-33601	CD	denotes	12
T13891	33601-33602	NN	denotes	%
T13892	33603-33606	NN	denotes	SDS
T13893	33622-33625	NN	denotes	gel
T13894	33607-33621	NN	denotes	polyacrylamide
T13895	33626-33630	IN	denotes	with
T13896	33631-33633	FW	denotes	in
T13897	33634-33639	FW	denotes	vitro
T13898	33640-33650	VBN	denotes	translated
T13899	33657-33666	NN	denotes	construct
T13900	33651-33656	NN	denotes	RXRβ3
T13901	33667-33673	VBN	denotes	pulled
T13902	33674-33678	RP	denotes	down
T13903	33679-33683	IN	denotes	with
T13904	33684-33687	NN	denotes	GST
T13905	33688-33693	NN	denotes	TACC2
T13906	33687-33688	HYPH	denotes	-
T13907	33694-33695	-LRB-	denotes	(
T13908	33695-33699	NN	denotes	Lane
T13909	33700-33701	CD	denotes	1
T13910	33701-33702	-RRB-	denotes	)
T13911	33703-33705	CC	denotes	or
T13912	33706-33709	NN	denotes	GST
T13913	33710-33711	-LRB-	denotes	(
T13914	33711-33715	NN	denotes	Lane
T13915	33716-33717	CD	denotes	2
T13916	33717-33718	-RRB-	denotes	)
T13917	33718-33719	:	denotes	;
T1844	1891-1894	VBD	denotes	was
T1845	1906-1908	IN	denotes	in
T1846	1909-1912	DT	denotes	the
T1847	1913-1919	NN	denotes	genome
T1848	1920-1922	IN	denotes	of
T1849	1923-1926	DT	denotes	the
T4441	11976-11978	IN	denotes	of
T4442	11979-11983	NN	denotes	gene
T4443	11984-11989	NN	denotes	order
T4444	11990-11993	MD	denotes	can
T4445	11994-11998	RB	denotes	also
T4446	12058-12067	VBD	denotes	attempted
T4447	12007-12012	NNS	denotes	clues
T4448	12013-12015	IN	denotes	to
T4449	12016-12019	DT	denotes	the
T13875	33528-33530	FW	denotes	In
T13876	33531-33536	FW	denotes	vitro
T13877	33537-33548	NN	denotes	interaction
T13878	33549-33551	IN	denotes	of
T13879	33552-33557	NN	denotes	RXRβ3
T13880	33558-33561	CC	denotes	and
T13881	33562-33568	NNS	denotes	TACC2s
T13882	33568-33569	.	denotes	.
T13883	33569-33774	sentence	denotes	Top panel: Autoradiograph of 12% SDS polyacrylamide gel with in vitro translated RXRβ3 construct pulled down with GST-TACC2 (Lane 1) or GST (Lane 2); Lane 3: 5% input of in vitro translated RXR-β protein.
T13884	33570-33573	JJ	denotes	Top
T13885	33574-33579	NN	denotes	panel
T13886	33581-33595	NN	denotes	Autoradiograph
T13887	33579-33581	:	denotes	:
T13888	33731-33736	NN	denotes	input
T4450	12020-12029	NN	denotes	evolution
T4451	12030-12032	IN	denotes	of
T4452	12033-12037	NN	denotes	gene
T4453	12038-12048	NN	denotes	regulation
T4454	12048-12050	,	denotes	,
T4455	12050-12052	PRP	denotes	we
T4456	12053-12057	RB	denotes	next
T4457	12068-12070	TO	denotes	to
T4458	12071-12076	VB	denotes	trace
T4459	12077-12080	DT	denotes	the
T4460	12081-12090	NN	denotes	evolution
T4461	12091-12093	IN	denotes	of
T4462	12094-12099	DT	denotes	these
T4463	12111-12119	NNS	denotes	segments
T4464	12100-12110	JJ	denotes	paralogous
T7673	26373-26374	-LRB-	denotes	(
T7674	26374-26378	NN	denotes	Fig.
T7675	26379-26381	CD	denotes	6B
T7676	26381-26382	-RRB-	denotes	)
T7677	26382-26384	,	denotes	,
T7678	26384-26387	CC	denotes	and
T7679	26388-26392	RB	denotes	thus
T4465	12120-12122	IN	denotes	by
T7772	26904-28208	sentence	denotes	Figure 6 Functional evolution of the TACC proteins modeled in C. elegans and D. melanogaster. (A). C. elegans interaction map shows empirically defined interactions of ceTAC, and extrapolated interactions defined by [28]. (B): Using the BIND database [29], DTACC directly binds to TBPH and CG14540, and thus indirectly to chromatin remodeling complexes (SWI/SNF and histone acetyltransferases), DNA damage repair machinery (via RAD23), and RNA splicing, transport and translational machinery. (C): Predicted interaction map for vertebrate TACCs, based upon ceTAC, suggests an indirect interaction with the nuclear hormone receptor RXRβ. It is also of interest that this predicts a functional interaction with the LDB family, members of which are also found in TACC containing paralogous segments noted in Figs 2, 3 and Additional file 1. (D): Predicted TACC interaction map based upon DTACC. (E): Vertebrate TACC interactions identified to date. ? denotes uncertainty over the identity of a functional vertebrate homologue. In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family. Because of the evolutionary conservation of the TACC domain, we would predict that some of the functional interactions seen in C. elegans and D. melanogaster would be observed in higher animals.
T7773	28014-28021	IN	denotes	Because
T7774	28084-28091	VB	denotes	predict
T7775	28022-28024	IN	denotes	of
T7776	28025-28028	DT	denotes	the
T7777	28042-28054	NN	denotes	conservation
T7778	28029-28041	JJ	denotes	evolutionary
T7779	28055-28057	IN	denotes	of
T4466	12123-12132	VBG	denotes	examining
T4467	12133-12136	DT	denotes	the
T4468	12137-12143	NN	denotes	genome
T1710	749-758	NNP	denotes	Anopheles
T1711	759-766	NNP	denotes	gambiae
T1712	767-771	VBD	denotes	were
T1713	772-776	RB	denotes	also
T1812	1828-1829	NN	denotes	A
T1813	1829-1830	IN	denotes	t
T1814	1831-1834	JJ	denotes	the
T1815	1835-1836	sentence	denotes	b
T1816	1835-1836	VBN	denotes	b
T1817	1836-1850	sentence	denotes	ase of the cho
T1818	1836-1837	NN	denotes	a
T1819	1837-1838	VBZ	denotes	s
T1820	1838-1839	JJ	denotes	e
T1821	1840-1842	IN	denotes	of
T1822	1843-1844	VBG	denotes	t
T1823	1844-1846	JJ	denotes	he
T1824	1847-1848	VBN	denotes	c
T1825	1848-1849	JJ	denotes	h
T1826	1849-1850	NNS	denotes	o
T1827	1850-1856	sentence	denotes	rdate
T1828	1850-1851	NN	denotes	r
T1829	1851-1852	JJ	denotes	d
T1830	1852-1853	CC	denotes	a
T1831	1853-1855	NN	denotes	te
T1832	1856-2054	sentence	denotes	branch of life, a single TACC gene was identified in the genome of the urochordate Ciona intestinalis [11], and a partial TACC sequence from an analysis of the Halocynthia rortezi EST database [12].
T1833	1895-1905	VBN	denotes	identified
T1834	1856-1857	NN	denotes	b
T1835	1859-1862	NN	denotes	nch
T1836	1857-1859	NN	denotes	ra
T1837	1863-1865	IN	denotes	of
T1838	1866-1870	NN	denotes	life
T1839	1870-1872	,	denotes	,
T1840	1872-1873	DT	denotes	a
T1841	1886-1890	NN	denotes	gene
T1842	1874-1880	JJ	denotes	single
T1843	1881-1885	NN	denotes	TACC
T1850	1927-1938	NN	denotes	urochordate
T4469	12144-12146	IN	denotes	of
T4470	12147-12150	DT	denotes	the
T4471	12151-12159	NN	denotes	tunicate
T4401	11093-11101	NNS	denotes	clusters
T4402	11087-11092	CD	denotes	three
T4403	11102-11105	VBP	denotes	are
T4404	11114-11116	IN	denotes	on
T4405	11117-11126	JJ	denotes	different
T4406	11127-11138	NNS	denotes	chromosomes
T4407	11139-11141	IN	denotes	in
T4408	11142-11147	NN	denotes	mouse
T4409	11148-11151	CC	denotes	and
T4410	11152-11155	NN	denotes	rat
T4411	11156-11157	-LRB-	denotes	(
T4412	11157-11161	NN	denotes	Fig.
T4413	11162-11163	CD	denotes	2
T4414	11163-11164	-RRB-	denotes	)
T4415	11164-11166	,	denotes	,
T4416	11166-11173	RB	denotes	further
T4417	11174-11184	VBG	denotes	suggesting
T4418	11185-11189	IN	denotes	that
T4419	11216-11226	VBN	denotes	transposed
T4420	11190-11194	DT	denotes	this
T4421	11195-11202	NN	denotes	cluster
T4422	11203-11205	IN	denotes	of
T4423	11206-11211	NNS	denotes	genes
T4424	11212-11215	VBD	denotes	was
T4425	11227-11231	IN	denotes	into
T4426	11232-11236	DT	denotes	this
T4427	11237-11243	NN	denotes	region
T4428	11244-11249	IN	denotes	after
T4429	11250-11253	DT	denotes	the
T4430	11269-11279	NN	denotes	divergence
T4431	11254-11261	NN	denotes	primate
T4432	11262-11268	NN	denotes	rodent
T4433	11261-11262	HYPH	denotes	/
T4434	11279-11280	.	denotes	.
T4435	11280-11281	sentence	denotes
T4436	11951-12268	sentence	denotes	Because the conservation of gene order can also provide clues to the evolution of gene regulation, we next attempted to trace the evolution of these paralogous segments by examining the genome of the tunicate C. intestinalis [11] and the most "primitive" compact vertebrate genome sequenced to date, T. rubripes [14].
T4437	11951-11958	IN	denotes	Because
T4438	11999-12006	VB	denotes	provide
T4439	11959-11962	DT	denotes	the
T4440	11963-11975	NN	denotes	conservation
T4472	12160-12162	NNP	denotes	C.
T4473	12163-12175	NNP	denotes	intestinalis
T4474	12176-12177	-LRB-	denotes	[
T4475	12177-12179	CD	denotes	11
T4476	12179-12180	-RRB-	denotes	]
T4477	12181-12184	CC	denotes	and
T4478	12185-12188	DT	denotes	the
T4479	12225-12231	NN	denotes	genome
T4480	12189-12193	JJS	denotes	most
T4481	12195-12204	JJ	denotes	primitive
T5120	15690-15695	VB	denotes	await
T5121	15609-15611	,	denotes	,
T5122	15611-15614	DT	denotes	the
T5123	15621-15631	NN	denotes	resolution
T5124	15615-15620	JJ	denotes	final
T5125	15632-15634	IN	denotes	of
T5126	15635-15638	DT	denotes	the
T5127	15647-15656	NN	denotes	evolution
T5128	15639-15646	JJ	denotes	initial
T5129	15657-15659	IN	denotes	of
T5130	15660-15665	DT	denotes	these
T5131	15677-15684	NN	denotes	segment
T5132	15666-15676	JJ	denotes	paralogous
T5133	15685-15689	MD	denotes	will
T5134	15696-15699	DT	denotes	the
T5135	15700-15710	NN	denotes	sequencing
T5136	15711-15713	IN	denotes	of
T5137	15714-15717	DT	denotes	the
T5138	15740-15747	NNS	denotes	genomes
T5139	15718-15727	NN	denotes	amphioxus
T5140	15728-15731	CC	denotes	and
T5141	15732-15739	NN	denotes	lamprey
T5142	15747-15749	,	denotes	,
T5143	15749-15754	WDT	denotes	which
T5144	15760-15764	VBP	denotes	have
T5145	15755-15759	RB	denotes	only
T5146	15765-15768	CD	denotes	one
T5147	15774-15778	NN	denotes	gene
T5148	15769-15773	NN	denotes	FGFR
T5149	15778-15780	,	denotes	,
T5150	15780-15783	CC	denotes	and
T5151	15784-15793	RB	denotes	therefore
T5152	15806-15813	VB	denotes	contain
T5153	15794-15800	MD	denotes	should
T5154	15801-15805	RB	denotes	only
T5155	15814-15817	CD	denotes	one
T5156	15818-15822	NN	denotes	copy
T5157	15823-15825	IN	denotes	of
T5158	15826-15829	DT	denotes	the
T5159	15850-15855	NNS	denotes	genes
T5160	15830-15835	JJ	denotes	other
R8078	T12469	T12470	amod	Phylogenetic,analysis
R8079	T12471	T12470	prep	of,analysis
R8080	T12472	T12473	det	the,members
R8081	T12473	T12471	pobj	members,of
R8082	T12474	T12473	compound	TACC,members
R8083	T12475	T12473	compound	family,members
R8084	T12476	T12470	prep	compared,analysis
R8085	T12477	T12476	prep	to,compared
R8086	T12478	T12479	amod	other,proteins
R8087	T12479	T12477	pobj	proteins,to
R8088	T12480	T12481	amod	coiled,coil
R8089	T12481	T12479	compound	coil,proteins
R8090	T12482	T12470	punct	.,analysis
R8091	T12484	T12485	det	The,tree
R8092	T12485	T12487	nsubjpass	tree,constructed
R8093	T12486	T12485	amod	phylogenetic,tree
R8094	T12488	T12487	auxpass	was,constructed
R8095	T12489	T12490	mark	as,described
R8096	T12490	T12487	advcl	described,constructed
R8097	T12491	T12490	prep	in,described
R8098	T12492	T12493	det	the,section
R8099	T12493	T12491	pobj	section,in
R8100	T12494	T12493	compound	Methods,section
R8101	T12495	T12487	punct	.,constructed
R8102	T12497	T12498	det	The,family
R8103	T12498	T12500	nsubj	family,defines
R8104	T12499	T12498	compound	TACC,family
R8105	T12501	T12502	det	a,subfamily
R8106	T12502	T12500	dobj	subfamily,defines
R8107	T12503	T12502	amod	separate,subfamily
R8108	T12504	T12502	prep	of,subfamily
R8109	T12505	T12506	amod	coiled,coil
R8110	T12506	T12507	npadvmod	coil,containing
R8111	T12507	T12508	amod	containing,proteins
R8112	T12508	T12504	pobj	proteins,of
R8113	T12509	T12502	punct	", ",subfamily
R8114	T12510	T12502	amod	distinct,subfamily
R8115	T12511	T12510	prep	from,distinct
R8116	T12512	T12513	amod	other,families
R8117	T12513	T12511	pobj	families,from
R8118	T12514	T12515	amod	coiled,coil
R8119	T12515	T12513	compound	coil,families
R8120	T12516	T12517	amod	such,as
R8121	T12517	T12513	prep	as,families
R8122	T12518	T12519	det	the,keratins
R8123	T12519	T12517	pobj	keratins,as
R8124	T12520	T12519	punct	", ",keratins
R8125	T12521	T12519	conj	RHAMM,keratins
R8126	T12522	T12521	cc	and,RHAMM
R8127	T12523	T12521	conj	tropomyosins,RHAMM
R8128	T12524	T12500	punct	.,defines
R8129	T12527	T12528	mark	that,form
R8130	T12528	T12526	ccomp	form,Note
R8131	T12529	T12530	det	the,proteins
R8132	T12530	T12528	nsubj	proteins,form
R8133	T12531	T12530	compound	RHAMM,proteins
R8134	T12532	T12533	det	a,branch
R8135	T12533	T12528	dobj	branch,form
R8136	T12534	T12533	amod	separate,branch
R8137	T12535	T12536	advmod	more,closely
R8138	T12536	T12537	advmod	closely,related
R8139	T12537	T12533	amod	related,branch
R8140	T12538	T12537	prep	to,related
R8141	T12539	T12540	det	the,tropomyosins
R8142	T12540	T12538	pobj	tropomyosins,to
R8143	T12541	T12540	cc	and,tropomyosins
R8144	T12542	T12543	npadvmod	kinesin,like
R8145	T12543	T12544	amod	like,proteins
R8146	T12544	T12540	conj	proteins,tropomyosins
R8147	T12545	T12544	punct	(,proteins
R8148	T12546	T12544	appos	KLP,proteins
R8149	T12547	T12537	punct	),related
R8150	T12548	T12537	punct	", ",related
R8151	T12549	T12537	prep	than,related
R8152	T12550	T12551	det	the,proteins
R8153	T12551	T12549	pobj	proteins,than
R8154	T12552	T12551	compound	TACC,proteins
R8155	T12553	T12526	punct	.,Note
R8159	T12611	T12612	amod	Linear,organization
R8160	T12613	T12612	prep	of,organization
R8161	T12614	T12615	compound	gene,clusters
R8162	T12615	T12613	pobj	clusters,of
R8163	T12616	T12612	acl	centering,organization
R8164	T12617	T12616	prep	upon,centering
R8165	T12618	T12619	det	the,loci
R8166	T12619	T12617	pobj	loci,upon
R8167	T12620	T12619	amod	chromosomal,loci
R8168	T12621	T12619	prep	of,loci
R8169	T12622	T12623	det	the,genes
R8170	T12623	T12621	pobj	genes,of
R8171	T12624	T12623	compound	FGFR,genes
R8172	T12625	T12619	prep	in,loci
R8173	T12626	T12625	pobj	humans,in
R8174	T12627	T12612	punct	.,organization
R8175	T12629	T12630	amod	Paralogous,genes
R8176	T12630	T12631	nsubjpass	genes,shown
R8177	T12632	T12630	amod	present,genes
R8178	T12633	T12632	prep	in,present
R8179	T12634	T12635	advmod	at,two
R8180	T12635	T12633	pobj	two,in
R8181	T12636	T12635	advmod	least,two
R8182	T12637	T12635	prep	of,two
R8183	T12638	T12639	det	the,loci
R8184	T12639	T12637	pobj	loci,of
R8185	T12640	T12639	nummod	four,loci
R8186	T12641	T12631	auxpass	are,shown
R8187	T12642	T12631	punct	", ",shown
R8188	T12643	T12631	prep	with,shown
R8189	T12644	T12645	det	the,exception
R8190	T12645	T12643	pobj	exception,with
R8191	T12646	T12645	prep	of,exception
R8192	T12647	T12648	det	the,region
R8193	T12648	T12646	pobj	region,of
R8194	T12649	T12648	prep	between,region
R8195	T12650	T12649	pobj	GPX3,between
R8196	T12651	T12650	cc	and,GPX3
R8197	T12652	T12650	conj	NKX2E,GPX3
R8198	T12653	T12650	prep	on,GPX3
R8199	T12654	T12653	pobj	chromosome,on
R8200	T12655	T12654	nummod	5,chromosome
R8201	T12656	T12648	punct	", ",region
R8202	T12657	T12658	dep	which,appears
R8203	T12658	T12648	relcl	appears,region
R8204	T12659	T12660	aux	to,represent
R8205	T12660	T12658	xcomp	represent,appears
R8206	T12661	T12662	det	a,series
R8207	T12662	T12660	dobj	series,represent
R8208	T12663	T12662	prep	of,series
R8209	T12664	T12665	amod	intervening,genes
R8210	T12665	T12663	pobj	genes,of
R8211	T12666	T12662	acl	inserted,series
R8212	T12667	T12666	prep	after,inserted
R8213	T12668	T12667	pobj	duplication,after
R8214	T12669	T12668	prep	of,duplication
R8215	T12670	T12671	det	the,clusters
R8216	T12671	T12669	pobj	clusters,of
R8217	T12672	T12673	nmod	4p16,5q32
R8218	T12673	T12671	nmod	5q32,clusters
R8219	T12674	T12673	punct	/,5q32
R8220	T12675	T12673	punct	-,5q32
R8221	T12676	T12673	nummod	35,5q32
R8222	T12677	T12648	punct	", ",region
R8223	T12678	T12648	cc	and,region
R8224	T12679	T12648	conj	genes,region
R8225	T12680	T12679	acl	mentioned,genes
R8226	T12681	T12680	prep	in,mentioned
R8227	T12682	T12681	pobj	Fig.,in
R8228	T12683	T12682	nummod	3,Fig.
R8229	T12684	T12631	punct	.,shown
R8230	T12686	T12687	amod	Corresponding,regions
R8231	T12687	T12691	nsubjpass	regions,indicated
R8232	T12688	T12687	amod	syntenic,regions
R8233	T12689	T12687	nmod	mouse,regions
R8234	T12690	T12687	amod	chromosomal,regions
R8235	T12692	T12693	punct	(,mm
R8236	T12693	T12687	parataxis	mm,regions
R8237	T12694	T12693	punct	*,mm
R8238	T12695	T12693	punct	),mm
R8239	T12696	T12691	auxpass	are,indicated
R8240	T12697	T12691	punct	.,indicated
R8241	T12699	T12700	compound	Takifugu,rubripes
R8242	T12700	T12701	compound	rubripes,scaffolds
R8243	T12701	T12702	nsubjpass	scaffolds,shown
R8244	T12703	T12702	auxpass	are,shown
R8245	T12704	T12705	punct	(,TR
R8246	T12705	T12702	parataxis	TR,shown
R8247	T12706	T12705	punct	*,TR
R8248	T12707	T12705	punct	),TR
R8249	T12708	T12709	dep	that,contain
R8250	T12709	T12702	ccomp	contain,shown
R8251	T12710	T12711	amod	more,one
R8252	T12711	T12713	nummod	one,gene
R8253	T12712	T12711	quantmod	than,one
R8254	T12713	T12709	dobj	gene,contain
R8255	T12714	T12713	amod	homologous,gene
R8256	T12715	T12713	prep	from,gene
R8257	T12716	T12717	det	these,clusters
R8258	T12717	T12715	pobj	clusters,from
R8259	T12718	T12702	punct	.,shown
R8260	T12720	T12721	amod	Further,details
R8261	T12721	T12722	nsubjpass	details,found
R8262	T12723	T12721	prep	on,details
R8263	T12724	T12725	det	the,location
R8264	T12725	T12723	pobj	location,on
R8265	T12726	T12725	prep	of,location
R8266	T12727	T12728	amod	paralogous,genes
R8267	T12728	T12726	pobj	genes,of
R8268	T12729	T12722	aux	can,found
R8269	T12730	T12722	auxpass	be,found
R8270	T12731	T12722	prep	in,found
R8271	T12732	T12733	punct	[,see
R8272	T12733	T12731	pcomp	see,in
R8273	T12734	T12735	amod	Additional,file
R8274	T12735	T12733	dobj	file,see
R8275	T12736	T12735	nummod	1,file
R8276	T12737	T12733	punct	],see
R8277	T12738	T12722	punct	.,found
R8282	T12815	T12814	prep	of,Formation
R8283	T12816	T12815	pobj	protoclusters,of
R8284	T12817	T12814	prep	in,Formation
R8285	T12818	T12819	compound	Takifugu,rubripes
R8286	T12819	T12817	pobj	rubripes,in
R8287	T12820	T12819	cc	and,rubripes
R8288	T12821	T12822	compound	Ciona,intestinalis
R8289	T12822	T12819	conj	intestinalis,rubripes
R8290	T12823	T12814	punct	: ,Formation
R8291	T12824	T12825	punct	(,A
R8292	T12825	T12827	meta	A,Structure
R8293	T12828	T12825	punct	),A
R8294	T12829	T12827	punct	: ,Structure
R8295	T12830	T12827	prep	of,Structure
R8296	T12831	T12832	det	the,scaffolds
R8297	T12832	T12830	pobj	scaffolds,of
R8298	T12833	T12832	amod	genomic,scaffolds
R8299	T12834	T12832	acl	containing,scaffolds
R8300	T12835	T12836	det	the,genes
R8301	T12836	T12834	dobj	genes,containing
R8302	T12837	T12838	nmod	Takifugu,rubripes
R8303	T12838	T12836	nmod	rubripes,genes
R8304	T12839	T12836	nmod	trTACC1A,genes
R8305	T12840	T12839	cc	and,trTACC1A
R8306	T12841	T12839	conj	trTACC1B,trTACC1A
R8307	T12842	T12827	punct	.,Structure
R8308	T12844	T12845	nsubj	Scaffold,contains
R8309	T12846	T12844	nummod	12,Scaffold
R8310	T12847	T12844	punct	", ",Scaffold
R8311	T12848	T12849	det	the,site
R8312	T12849	T12844	appos	site,Scaffold
R8313	T12850	T12849	prep	for,site
R8314	T12851	T12852	det	the,gene
R8315	T12852	T12850	pobj	gene,for
R8316	T12853	T12852	compound	trTACC1A,gene
R8317	T12854	T12845	dobj	genes,contains
R8318	T12855	T12854	acl	found,genes
R8319	T12856	T12855	prep	with,found
R8320	T12857	T12858	preconj	either,homologues
R8321	T12858	T12856	pobj	homologues,with
R8322	T12859	T12858	cc	or,homologues
R8323	T12860	T12858	conj	orthologues,homologues
R8324	T12861	T12855	prep	on,found
R8325	T12862	T12863	det	the,arm
R8326	T12863	T12861	pobj	arm,on
R8327	T12864	T12863	amod	distal,arm
R8328	T12865	T12863	amod	long,arm
R8329	T12866	T12863	prep	of,arm
R8330	T12867	T12868	amod	human,4p16
R8331	T12868	T12866	pobj	4p16,of
R8332	T12869	T12868	nmod	chromosome,4p16
R8333	T12870	T12868	nummod	10,4p16
R8334	T12871	T12868	cc	and,4p16
R8335	T12872	T12845	punct	.,contains
R8336	T12874	T12875	det	This,scaffold
R8337	T12875	T12876	nsubj	scaffold,has
R8338	T12877	T12876	punct	", ",has
R8339	T12878	T12876	advmod	therefore,has
R8340	T12879	T12876	punct	", ",has
R8341	T12880	T12876	dobj	some,has
R8342	T12881	T12880	prep	of,some
R8343	T12882	T12883	det	the,characteristics
R8344	T12883	T12881	pobj	characteristics,of
R8345	T12884	T12883	prep	of,characteristics
R8346	T12885	T12886	det	the,ancestor
R8347	T12886	T12884	pobj	ancestor,of
R8348	T12887	T12886	amod	predicted,ancestor
R8349	T12888	T12886	amod	immediate,ancestor
R8350	T12889	T12886	prep	of,ancestor
R8351	T12890	T12891	det	the,segment
R8352	T12891	T12889	pobj	segment,of
R8353	T12892	T12893	nmod	TACC1,TACC2
R8354	T12893	T12891	nmod	TACC2,segment
R8355	T12894	T12893	punct	/,TACC2
R8356	T12895	T12891	amod	chromosomal,segment
R8357	T12896	T12876	punct	.,has
R8358	T12898	T12899	nsubjpass	trTACC1B,found
R8359	T12900	T12899	auxpass	is,found
R8360	T12901	T12899	prep	on,found
R8361	T12902	T12901	pobj	scaffold,on
R8362	T12903	T12902	nummod	191,scaffold
R8363	T12904	T12902	punct	", ",scaffold
R8364	T12905	T12906	dep	which,contains
R8365	T12906	T12902	relcl	contains,scaffold
R8366	T12907	T12906	dobj	orthologues,contains
R8367	T12908	T12907	prep	of,orthologues
R8368	T12909	T12908	pobj	genes,of
R8369	T12910	T12909	acl	found,genes
R8370	T12911	T12910	prep	in,found
R8371	T12912	T12913	det	the,arm
R8372	T12913	T12911	pobj	arm,in
R8373	T12914	T12913	amod	proximal,arm
R8374	T12915	T12913	amod	short,arm
R8375	T12916	T12913	prep	of,arm
R8376	T12917	T12918	amod	human,chromosome
R8377	T12918	T12916	pobj	chromosome,of
R8378	T12919	T12918	nummod	8,chromosome
R8379	T12920	T12899	punct	.,found
R8380	T12922	T12923	punct	(,B
R8381	T12923	T12924	meta	B,clusters
R8382	T12925	T12923	punct	),B
R8383	T12926	T12924	punct	: ,clusters
R8384	T12927	T12928	compound	Ciona,intestinalis
R8385	T12928	T12924	compound	intestinalis,clusters
R8386	T12929	T12924	acl	containing,clusters
R8387	T12930	T12929	dobj	genes,containing
R8388	T12931	T12930	acl	found,genes
R8389	T12932	T12931	prep	in,found
R8390	T12933	T12934	amod	paralogous,segments
R8391	T12934	T12932	pobj	segments,in
R8392	T12935	T12931	prep	on,found
R8393	T12936	T12937	amod	human,4p16
R8394	T12937	T12935	pobj	4p16,on
R8395	T12938	T12937	nummod	8,4p16
R8396	T12939	T12937	punct	", ",4p16
R8397	T12940	T12937	punct	", ",4p16
R8398	T12941	T12937	conj	10q,4p16
R8399	T12942	T12941	cc	and,10q
R8400	T12943	T12941	conj	5q,10q
R8401	T12944	T12924	punct	.,clusters
R8402	T12994	T12995	amod	Genomic,structure
R8403	T12996	T12995	prep	of,structure
R8404	T12997	T12998	det	the,genes
R8405	T12998	T12996	pobj	genes,of
R8406	T12999	T12998	compound	TACC,genes
R8407	T13000	T12995	punct	.,structure
R8408	T13002	T13003	amod	Conserved,regions
R8409	T13003	T13004	nsubjpass	regions,shown
R8410	T13005	T13003	acl	known,regions
R8411	T13006	T13007	aux	to,bind
R8412	T13007	T13005	xcomp	bind,known
R8413	T13008	T13009	compound	protein,factors
R8414	T13009	T13007	dobj	factors,bind
R8415	T13010	T13007	prep	in,bind
R8416	T13011	T13012	det	all,proteins
R8417	T13012	T13010	pobj	proteins,in
R8418	T13013	T13012	amod	human,proteins
R8419	T13014	T13012	compound	TACC,proteins
R8420	T13015	T13004	auxpass	are,shown
R8421	T13016	T13004	punct	.,shown
R8422	T13018	T13019	det	The,repeat
R8423	T13019	T13021	nsubjpass	repeat,known
R8424	T13020	T13019	compound	SDP,repeat
R8425	T13022	T13019	prep	of,repeat
R8426	T13023	T13024	amod	human,TACC1
R8427	T13024	T13022	pobj	TACC1,of
R8428	T13025	T13024	punct	-,TACC1
R8429	T13026	T13024	nummod	3,TACC1
R8430	T13027	T13021	auxpass	is,known
R8431	T13028	T13029	aux	to,bind
R8432	T13029	T13021	xcomp	bind,known
R8433	T13030	T13029	dobj	GAS41,bind
R8434	T13031	T13032	punct	(,15
R8435	T13032	T13021	parataxis	15,known
R8436	T13033	T13032	punct	[,15
R8437	T13034	T13032	nummod	3,15
R8438	T13035	T13032	punct	",",15
R8439	T13036	T13032	punct	],15
R8440	T13037	T13032	cc	and,15
R8441	T13038	T13039	nsubj	data,shown
R8442	T13039	T13032	conj	shown,15
R8443	T13040	T13039	neg	not,shown
R8444	T13041	T13032	punct	),15
R8445	T13042	T13021	punct	.,known
R8446	T13044	T13045	det	The,domain
R8447	T13045	T13047	nsubj	domain,binds
R8448	T13046	T13045	compound	TACC,domain
R8449	T13048	T13049	compound	ch,TOG
R8450	T13049	T13047	dobj	TOG,binds
R8451	T13050	T13049	punct	-,TOG
R8452	T13051	T13049	cc	and,TOG
R8453	T13052	T13049	conj	members,TOG
R8454	T13053	T13052	prep	of,members
R8455	T13054	T13055	det	the,kinases
R8456	T13055	T13053	pobj	kinases,of
R8457	T13056	T13055	compound	Aurora,kinases
R8458	T13057	T13047	prep	in,binds
R8459	T13058	T13059	det	all,species
R8460	T13059	T13057	pobj	species,in
R8461	T13060	T13059	acl	examined,species
R8462	T13061	T13060	prep	to,examined
R8463	T13062	T13061	pobj	date,to
R8464	T13063	T13047	punct	.,binds
R8465	T13065	T13066	det	This,motif
R8466	T13066	T13067	nsubjpass	motif,encoded
R8467	T13068	T13067	auxpass	is,encoded
R8468	T13069	T13067	advmod	characteristically,encoded
R8469	T13070	T13067	agent	by,encoded
R8470	T13071	T13072	det	the,exons
R8471	T13072	T13070	pobj	exons,by
R8472	T13073	T13072	nummod	3,exons
R8473	T13074	T13073	punct	',3
R8474	T13075	T13072	prep	of,exons
R8475	T13076	T13077	det	the,genes
R8476	T13077	T13075	pobj	genes,of
R8477	T13078	T13077	compound	TACC,genes
R8478	T13079	T13067	punct	.,encoded
R8479	T13081	T13082	det	The,size
R8480	T13082	T13083	nsubjpass	size,shown
R8481	T13084	T13082	prep	of,size
R8482	T13085	T13086	det	the,isoform
R8483	T13086	T13084	pobj	isoform,of
R8484	T13087	T13086	amod	largest,isoform
R8485	T13088	T13086	prep	for,isoform
R8486	T13089	T13090	det	each,gene
R8487	T13090	T13088	pobj	gene,for
R8488	T13091	T13083	auxpass	is,shown
R8489	T13092	T13083	punct	.,shown
R8490	T13211	T13212	amod	Alternative,splicing
R8491	T13213	T13212	prep	of,splicing
R8492	T13214	T13215	det	the,gene
R8493	T13215	T13213	pobj	gene,of
R8494	T13216	T13215	amod	human,gene
R8495	T13217	T13215	compound	TACC1,gene
R8496	T13218	T13212	punct	.,splicing
R8497	T13220	T13221	punct	(,A
R8498	T13221	T13222	meta	A,identified
R8499	T13223	T13221	punct	),A
R8500	T13224	T13222	punct	: ,identified
R8501	T13225	T13226	nummod	Seven,variants
R8502	T13226	T13222	nsubjpass	variants,identified
R8503	T13227	T13226	compound	splice,variants
R8504	T13228	T13222	aux	have,identified
R8505	T13229	T13222	auxpass	been,identified
R8506	T13230	T13222	prep	for,identified
R8507	T13231	T13232	amod	human,TACC1
R8508	T13232	T13230	pobj	TACC1,for
R8509	T13233	T13234	punct	(,A
R8510	T13234	T13222	parataxis	A,identified
R8511	T13235	T13236	punct	-,F
R8512	T13236	T13234	prep	F,A
R8513	T13237	T13234	cc	and,A
R8514	T13238	T13234	conj	S,A
R8515	T13239	T13234	punct	),A
R8516	T13240	T13222	punct	.,identified
R8517	T13242	T13243	nsubj	We,identified
R8518	T13244	T13243	aux	have,identified
R8519	T13245	T13243	advmod	also,identified
R8520	T13246	T13247	amod	additional,variants
R8521	T13247	T13243	dobj	variants,identified
R8522	T13248	T13247	compound	splice,variants
R8523	T13249	T13250	punct	(,G
R8524	T13250	T13247	parataxis	G,variants
R8525	T13251	T13252	punct	-,I
R8526	T13252	T13250	prep	I,G
R8527	T13253	T13250	punct	),G
R8528	T13254	T13243	prep	from,identified
R8529	T13255	T13256	compound	database,analysis
R8530	T13256	T13254	pobj	analysis,from
R8531	T13257	T13256	cc	and,analysis
R8532	T13258	T13259	compound	rt,PCR
R8533	T13259	T13261	compound	PCR,analysis
R8534	T13260	T13259	punct	-,PCR
R8535	T13261	T13256	conj	analysis,analysis
R8536	T13262	T13261	prep	of,analysis
R8537	T13263	T13264	amod	human,brain
R8538	T13264	T13265	compound	brain,RNA
R8539	T13265	T13262	pobj	RNA,of
R8540	T13266	T13243	punct	.,identified
R8541	T13268	T13269	punct	(,B
R8542	T13269	T13270	meta	B,splicing
R8543	T13271	T13269	punct	),B
R8544	T13272	T13270	punct	: ,splicing
R8545	T13273	T13270	amod	Alternative,splicing
R8546	T13274	T13270	prep	of,splicing
R8547	T13275	T13274	pobj	TACC1,of
R8548	T13276	T13270	prep	in,splicing
R8549	T13277	T13278	det	the,brain
R8550	T13278	T13276	pobj	brain,in
R8551	T13279	T13278	amod	human,brain
R8552	T13280	T13270	punct	.,splicing
R8553	T13282	T13283	compound	rt,PCR
R8554	T13283	T13285	compound	PCR,analysis
R8555	T13284	T13283	punct	-,PCR
R8556	T13285	T13286	nsubj	analysis,confirms
R8557	T13287	T13286	dobj	splicing,confirms
R8558	T13288	T13287	prep	of,splicing
R8559	T13289	T13290	det	the,exon
R8560	T13290	T13288	pobj	exon,of
R8561	T13291	T13290	amod	untranslated,exon
R8562	T13292	T13290	nummod	1a,exon
R8563	T13293	T13287	prep	to,splicing
R8564	T13294	T13293	pobj	exon,to
R8565	T13295	T13294	nummod	1,exon
R8566	T13296	T13287	punct	", ",splicing
R8567	T13297	T13287	prep	with,splicing
R8568	T13298	T13297	pobj	retention,with
R8569	T13299	T13298	prep	of,retention
R8570	T13300	T13301	det	the,methionine
R8571	T13301	T13299	pobj	methionine,of
R8572	T13302	T13303	advmod	originally,defined
R8573	T13303	T13301	amod	defined,methionine
R8574	T13304	T13301	compound	start,methionine
R8575	T13305	T13306	punct	(,NP_006274
R8576	T13306	T13286	parataxis	NP_006274,confirms
R8577	T13307	T13306	nmod	GB,NP_006274
R8578	T13308	T13306	punct	:,NP_006274
R8579	T13309	T13306	punct	),NP_006274
R8580	T13310	T13311	punct	(,1
R8581	T13311	T13286	parataxis	1,confirms
R8582	T13312	T13313	compound	Variant,A
R8583	T13313	T13311	dep	A,1
R8584	T13314	T13313	punct	*,A
R8585	T13315	T13311	punct	", ",1
R8586	T13316	T13311	nmod	lanes,1
R8587	T13317	T13311	cc	and,1
R8588	T13318	T13311	conj	3,1
R8589	T13319	T13311	punct	),1
R8590	T13320	T13286	punct	.,confirms
R8591	T13322	T13323	nsubj	Exon,splices
R8592	T13324	T13322	nummod	1a,Exon
R8593	T13325	T13323	advmod	also,splices
R8594	T13326	T13323	prep	to,splices
R8595	T13327	T13326	pobj	exon,to
R8596	T13328	T13327	nummod	2,exon
R8597	T13329	T13323	punct	", ",splices
R8598	T13330	T13323	advcl	removing,splices
R8599	T13331	T13332	det	the,motif
R8600	T13332	T13330	dobj	motif,removing
R8601	T13333	T13334	compound	L,Sm7
R8602	T13334	T13332	compound	Sm7,motif
R8603	T13335	T13334	punct	-,Sm7
R8604	T13336	T13332	compound	binding,motif
R8605	T13337	T13338	punct	(,3
R8606	T13338	T13323	parataxis	3,splices
R8607	T13339	T13340	compound	variant,I
R8608	T13340	T13338	dep	I,3
R8609	T13341	T13338	punct	", ",3
R8610	T13342	T13338	nmod	lanes,3
R8611	T13343	T13338	punct	",",3
R8612	T13344	T13338	conj	12,3
R8613	T13345	T13344	cc	and,12
R8614	T13346	T13344	conj	13,12
R8615	T13347	T13338	punct	),3
R8616	T13348	T13323	punct	.,splices
R8617	T13350	T13351	nsubj	Variants,remove
R8618	T13352	T13353	dep	that,delete
R8619	T13353	T13350	relcl	delete,Variants
R8620	T13354	T13353	advmod	functionally,delete
R8621	T13355	T13356	nmod	exons,2
R8622	T13356	T13353	dobj	2,delete
R8623	T13357	T13356	cc	and,2
R8624	T13358	T13357	punct	/,and
R8625	T13359	T13357	cc	or,and
R8626	T13360	T13356	conj	3,2
R8627	T13361	T13350	punct	", ",Variants
R8628	T13362	T13363	amod	such,as
R8629	T13363	T13350	prep	as,Variants
R8630	T13364	T13365	compound	variant,C
R8631	T13365	T13363	pobj	C,as
R8632	T13366	T13367	punct	(,lane
R8633	T13367	T13365	parataxis	lane,C
R8634	T13368	T13367	nummod	15,lane
R8635	T13369	T13367	punct	),lane
R8636	T13370	T13351	advmod	also,remove
R8637	T13371	T13372	det	the,signals
R8638	T13372	T13351	dobj	signals,remove
R8639	T13373	T13372	amod	predicted,signals
R8640	T13374	T13375	amod	nuclear,localization
R8641	T13375	T13372	compound	localization,signals
R8642	T13376	T13372	punct	", ",signals
R8643	T13377	T13372	cc	and,signals
R8644	T13378	T13379	det	the,domains
R8645	T13379	T13372	conj	domains,signals
R8646	T13380	T13379	compound	binding,domains
R8647	T13381	T13379	prep	for,domains
R8648	T13382	T13381	pobj	GAS41,for
R8649	T13383	T13382	cc	and,GAS41
R8650	T13384	T13382	conj	PCTAIRE2BP,GAS41
R8651	T13385	T13351	punct	.,remove
R8652	T13387	T13388	det	These,variants
R8653	T13388	T13389	nsubj	variants,retain
R8654	T13390	T13389	aux	would,retain
R8655	T13391	T13392	det	the,domain
R8656	T13392	T13389	dobj	domain,retain
R8657	T13393	T13392	compound	TACC,domain
R8658	T13394	T13392	punct	", ",domain
R8659	T13395	T13392	cc	and,domain
R8660	T13396	T13397	advmod	therefore,potential
R8661	T13397	T13392	conj	potential,domain
R8662	T13398	T13397	det	the,potential
R8663	T13399	T13400	aux	to,bind
R8664	T13400	T13397	acl	bind,potential
R8665	T13401	T13400	prep	to,bind
R8666	T13402	T13403	compound	ch,TOG
R8667	T13403	T13401	pobj	TOG,to
R8668	T13404	T13403	punct	-,TOG
R8669	T13405	T13403	cc	and,TOG
R8670	T13406	T13407	compound	Aurora,A
R8671	T13407	T13408	compound	A,kinase
R8672	T13408	T13403	conj	kinase,TOG
R8673	T13409	T13400	prep	in,bind
R8674	T13410	T13411	det	the,centrosome
R8675	T13411	T13409	pobj	centrosome,in
R8676	T13412	T13389	punct	.,retain
R8677	T13414	T13415	dep	Lane,X1R
R8678	T13415	T13420	dep	X1R,ladder
R8679	T13416	T13414	nummod	1,Lane
R8680	T13417	T13415	punct	: ,X1R
R8681	T13418	T13415	compound	EF,X1R
R8682	T13419	T13415	punct	/,X1R
R8683	T13421	T13420	punct	", ",ladder
R8684	T13422	T13423	dep	Lane,BX647R
R8685	T13423	T13420	dep	BX647R,ladder
R8686	T13424	T13422	nummod	2,Lane
R8687	T13425	T13423	punct	: ,BX647R
R8688	T13426	T13423	compound	EF,BX647R
R8689	T13427	T13423	punct	/,BX647R
R8690	T13428	T13420	punct	", ",ladder
R8691	T13429	T13430	dep	Lane,6SPR
R8692	T13430	T13420	dep	6SPR,ladder
R8693	T13431	T13429	nummod	3,Lane
R8694	T13432	T13430	punct	: ,6SPR
R8695	T13433	T13430	compound	EF,6SPR
R8696	T13434	T13430	punct	/,6SPR
R8697	T13435	T13420	punct	", ",ladder
R8698	T13436	T13437	dep	Lane,1DR
R8699	T13437	T13420	dep	1DR,ladder
R8700	T13438	T13436	nummod	4,Lane
R8701	T13439	T13437	punct	: ,1DR
R8702	T13440	T13437	compound	EF,1DR
R8703	T13441	T13437	punct	/,1DR
R8704	T13442	T13420	punct	", ",ladder
R8705	T13443	T13444	dep	Lane,128R
R8706	T13444	T13420	dep	128R,ladder
R8707	T13445	T13443	nummod	5,Lane
R8708	T13446	T13444	punct	", ",128R
R8709	T13447	T13444	compound	EF,128R
R8710	T13448	T13444	punct	/,128R
R8711	T13449	T13420	punct	", ",ladder
R8712	T13450	T13451	dep	Lane,X1R
R8713	T13451	T13420	dep	X1R,ladder
R8714	T13452	T13450	nummod	6,Lane
R8715	T13453	T13451	compound	X3F,X1R
R8716	T13454	T13451	punct	/,X1R
R8717	T13455	T13420	punct	", ",ladder
R8718	T13456	T13457	dep	Lane,BX647R
R8719	T13457	T13420	dep	BX647R,ladder
R8720	T13458	T13456	nummod	7,Lane
R8721	T13459	T13457	punct	: ,BX647R
R8722	T13460	T13457	compound	X3F,BX647R
R8723	T13461	T13457	punct	/,BX647R
R8724	T13462	T13420	punct	", ",ladder
R8725	T13463	T13464	dep	Lane,6SPR
R8726	T13464	T13420	dep	6SPR,ladder
R8727	T13465	T13463	nummod	8,Lane
R8728	T13466	T13464	punct	: ,6SPR
R8729	T13467	T13464	compound	X3F,6SPR
R8730	T13468	T13464	punct	/,6SPR
R8731	T13469	T13420	punct	", ",ladder
R8732	T13470	T13471	dep	Lane,1DR
R8733	T13471	T13420	dep	1DR,ladder
R8734	T13472	T13470	nummod	9,Lane
R8735	T13473	T13471	punct	: ,1DR
R8736	T13474	T13471	compound	X3F,1DR
R8737	T13475	T13471	punct	/,1DR
R8738	T13476	T13420	punct	", ",ladder
R8739	T13477	T13478	dep	Lane,128R
R8740	T13478	T13420	dep	128R,ladder
R8741	T13479	T13477	nummod	10,Lane
R8742	T13480	T13478	punct	", ",128R
R8743	T13481	T13478	compound	X3F,128R
R8744	T13482	T13478	punct	/,128R
R8745	T13483	T13420	punct	", ",ladder
R8746	T13484	T13485	dep	Lane,X1R
R8747	T13485	T13420	dep	X1R,ladder
R8748	T13486	T13484	nummod	11,Lane
R8749	T13487	T13485	punct	: ,X1R
R8750	T13488	T13485	compound	1DF,X1R
R8751	T13489	T13485	punct	/,X1R
R8752	T13490	T13420	punct	", ",ladder
R8753	T13491	T13492	dep	Lane,BX647R
R8754	T13492	T13420	dep	BX647R,ladder
R8755	T13493	T13491	nummod	12,Lane
R8756	T13494	T13492	punct	: ,BX647R
R8757	T13495	T13492	compound	1DF,BX647R
R8758	T13496	T13492	punct	/,BX647R
R8759	T13497	T13420	punct	", ",ladder
R8760	T13498	T13499	dep	Lane,6SPR
R8761	T13499	T13420	dep	6SPR,ladder
R8762	T13500	T13498	nummod	13,Lane
R8763	T13501	T13499	punct	: ,6SPR
R8764	T13502	T13499	compound	1DF,6SPR
R8765	T13503	T13499	punct	/,6SPR
R8766	T13504	T13420	punct	", ",ladder
R8767	T13505	T13506	dep	Lane,1DR
R8768	T13506	T13420	dep	1DR,ladder
R8769	T13507	T13505	nummod	14,Lane
R8770	T13508	T13506	punct	: ,1DR
R8771	T13509	T13506	compound	1DF,1DR
R8772	T13510	T13506	punct	/,1DR
R8773	T13511	T13420	punct	", ",ladder
R8774	T13512	T13513	dep	Lane,128R
R8775	T13513	T13420	dep	128R,ladder
R8776	T13514	T13512	nummod	15,Lane
R8777	T13515	T13513	punct	: ,128R
R8778	T13516	T13513	compound	1DF,128R
R8779	T13517	T13513	punct	/,128R
R8780	T13518	T13420	punct	", ",ladder
R8781	T13519	T13420	dep	Lane,ladder
R8782	T13520	T13519	nummod	16,Lane
R8783	T13521	T13420	punct	: ,ladder
R8784	T13522	T13420	nmod	Biorad,ladder
R8785	T13523	T13524	nummod	1,kb+
R8786	T13524	T13525	compound	kb+,Size
R8787	T13525	T13420	compound	Size,ladder
R8788	T13526	T13420	punct	.,ladder
R8791	T13617	T13618	amod	Functional,evolution
R8792	T13619	T13618	prep	of,evolution
R8793	T13620	T13621	det	the,proteins
R8794	T13621	T13619	pobj	proteins,of
R8795	T13622	T13621	compound	TACC,proteins
R8796	T13623	T13618	acl	modeled,evolution
R8797	T13624	T13623	prep	in,modeled
R8798	T13625	T13626	compound	C.,elegans
R8799	T13626	T13624	pobj	elegans,in
R8800	T13627	T13626	cc	and,elegans
R8801	T13628	T13629	compound	D.,melanogaster
R8802	T13629	T13626	conj	melanogaster,elegans
R8803	T13630	T13618	punct	.,evolution
R8804	T13632	T13633	punct	(,A
R8805	T13633	T13634	meta	A,shows
R8806	T13635	T13633	punct	),A
R8807	T13636	T13633	punct	.,A
R8808	T13637	T13638	compound	C.,elegans
R8809	T13638	T13639	compound	elegans,map
R8810	T13639	T13634	nsubj	map,shows
R8811	T13640	T13639	compound	interaction,map
R8812	T13641	T13642	advmod	empirically,defined
R8813	T13642	T13643	amod	defined,interactions
R8814	T13643	T13634	dobj	interactions,shows
R8815	T13644	T13643	prep	of,interactions
R8816	T13645	T13644	pobj	ceTAC,of
R8817	T13646	T13643	punct	", ",interactions
R8818	T13647	T13643	cc	and,interactions
R8819	T13648	T13649	amod	extrapolated,interactions
R8820	T13649	T13643	conj	interactions,interactions
R8821	T13650	T13649	acl	defined,interactions
R8822	T13651	T13650	agent	by,defined
R8823	T13652	T13651	punct	[,by
R8824	T13653	T13651	pobj	28,by
R8825	T13654	T13651	punct	],by
R8826	T13655	T13634	punct	.,shows
R8827	T13657	T13658	punct	(,B
R8828	T13658	T13659	meta	B,binds
R8829	T13660	T13658	punct	),B
R8830	T13661	T13659	punct	: ,binds
R8831	T13662	T13659	advcl	Using,binds
R8832	T13663	T13664	det	the,database
R8833	T13664	T13662	dobj	database,Using
R8834	T13665	T13664	compound	BIND,database
R8835	T13666	T13667	punct	[,29
R8836	T13667	T13662	parataxis	29,Using
R8837	T13668	T13667	punct	],29
R8838	T13669	T13659	punct	", ",binds
R8839	T13670	T13659	nsubj	DTACC,binds
R8840	T13671	T13659	advmod	directly,binds
R8841	T13672	T13659	prep	to,binds
R8842	T13673	T13672	pobj	TBPH,to
R8843	T13674	T13673	cc	and,TBPH
R8844	T13675	T13673	conj	CG14540,TBPH
R8845	T13676	T13659	punct	", ",binds
R8846	T13677	T13659	cc	and,binds
R8847	T13678	T13659	conj	thus,binds
R8848	T13679	T13678	advmod	indirectly,thus
R8849	T13680	T13678	prep	to,thus
R8850	T13681	T13682	compound	chromatin,remodeling
R8851	T13682	T13683	compound	remodeling,complexes
R8852	T13683	T13680	pobj	complexes,to
R8853	T13684	T13683	punct	(,complexes
R8854	T13685	T13686	compound	SWI,SNF
R8855	T13686	T13683	appos	SNF,complexes
R8856	T13687	T13686	punct	/,SNF
R8857	T13688	T13686	cc	and,SNF
R8858	T13689	T13690	compound	histone,acetyltransferases
R8859	T13690	T13686	conj	acetyltransferases,SNF
R8860	T13691	T13683	punct	),complexes
R8861	T13692	T13683	punct	", ",complexes
R8862	T13693	T13694	compound	DNA,damage
R8863	T13694	T13695	compound	damage,repair
R8864	T13695	T13696	compound	repair,machinery
R8865	T13696	T13683	conj	machinery,complexes
R8866	T13697	T13696	punct	(,machinery
R8867	T13698	T13696	prep	via,machinery
R8868	T13699	T13698	pobj	RAD23,via
R8869	T13700	T13696	punct	),machinery
R8870	T13701	T13696	punct	", ",machinery
R8871	T13702	T13696	cc	and,machinery
R8872	T13703	T13704	nmod	RNA,splicing
R8873	T13704	T13705	nmod	splicing,machinery
R8874	T13705	T13696	conj	machinery,machinery
R8875	T13706	T13704	punct	", ",splicing
R8876	T13707	T13704	conj	transport,splicing
R8877	T13708	T13707	cc	and,transport
R8878	T13709	T13707	conj	translational,transport
R8879	T13710	T13659	punct	.,binds
R8880	T13712	T13713	punct	(,C
R8881	T13713	T13714	meta	C,suggests
R8882	T13715	T13713	punct	),C
R8883	T13716	T13714	punct	: ,suggests
R8884	T13717	T13718	amod	Predicted,interaction
R8885	T13718	T13719	compound	interaction,map
R8886	T13719	T13714	nsubj	map,suggests
R8887	T13720	T13719	prep	for,map
R8888	T13721	T13722	compound	vertebrate,TACCs
R8889	T13722	T13720	pobj	TACCs,for
R8890	T13723	T13719	punct	", ",map
R8891	T13724	T13719	prep	based,map
R8892	T13725	T13724	prep	upon,based
R8893	T13726	T13725	pobj	ceTAC,upon
R8894	T13727	T13714	punct	", ",suggests
R8895	T13728	T13729	det	an,interaction
R8896	T13729	T13714	dobj	interaction,suggests
R8897	T13730	T13729	amod	indirect,interaction
R8898	T13731	T13729	prep	with,interaction
R8899	T13732	T13733	det	the,receptor
R8900	T13733	T13731	pobj	receptor,with
R8901	T13734	T13733	amod	nuclear,receptor
R8902	T13735	T13733	compound	hormone,receptor
R8903	T13736	T13733	appos	RXRβ,receptor
R8904	T13737	T13714	punct	.,suggests
R8905	T13739	T13740	nsubj	It,is
R8906	T13741	T13740	advmod	also,is
R8907	T13742	T13740	prep	of,is
R8908	T13743	T13742	pobj	interest,of
R8909	T13744	T13745	mark	that,predicts
R8910	T13745	T13740	ccomp	predicts,is
R8911	T13746	T13745	nsubj	this,predicts
R8912	T13747	T13748	det	a,interaction
R8913	T13748	T13745	dobj	interaction,predicts
R8914	T13749	T13748	amod	functional,interaction
R8915	T13750	T13748	prep	with,interaction
R8916	T13751	T13752	det	the,family
R8917	T13752	T13750	pobj	family,with
R8918	T13753	T13752	compound	LDB,family
R8919	T13754	T13752	punct	", ",family
R8920	T13755	T13756	dep	members,found
R8921	T13756	T13752	relcl	found,family
R8922	T13757	T13755	prep	of,members
R8923	T13758	T13757	pobj	which,of
R8924	T13759	T13756	auxpass	are,found
R8925	T13760	T13756	advmod	also,found
R8926	T13761	T13756	prep	in,found
R8927	T13762	T13763	npadvmod	TACC,containing
R8928	T13763	T13764	amod	containing,segments
R8929	T13764	T13761	pobj	segments,in
R8930	T13765	T13764	amod	paralogous,segments
R8931	T13766	T13756	advcl	noted,found
R8932	T13767	T13766	prep	in,noted
R8933	T13768	T13769	nmod	Figs,3
R8934	T13769	T13767	pobj	3,in
R8935	T13770	T13769	nummod	2,3
R8936	T13771	T13769	punct	", ",3
R8937	T13772	T13769	cc	and,3
R8938	T13773	T13774	amod	Additional,file
R8939	T13774	T13769	conj	file,3
R8940	T13775	T13774	nummod	1,file
R8941	T13776	T13740	punct	.,is
R8942	T13778	T13779	punct	(,D
R8943	T13779	T13780	meta	D,map
R8944	T13781	T13779	punct	),D
R8945	T13782	T13780	punct	: ,map
R8946	T13783	T13780	amod	Predicted,map
R8947	T13784	T13780	compound	TACC,map
R8948	T13785	T13780	compound	interaction,map
R8949	T13786	T13780	prep	based,map
R8950	T13787	T13786	prep	upon,based
R8951	T13788	T13787	pobj	DTACC,upon
R8952	T13789	T13780	punct	.,map
R8953	T13791	T13792	punct	(,E
R8954	T13792	T13793	meta	E,interactions
R8955	T13794	T13792	punct	),E
R8956	T13795	T13793	punct	: ,interactions
R8957	T13796	T13793	compound	Vertebrate,interactions
R8958	T13797	T13793	compound	TACC,interactions
R8959	T13798	T13793	acl	identified,interactions
R8960	T13799	T13798	prep	to,identified
R8961	T13800	T13799	pobj	date,to
R8962	T13801	T13793	punct	.,interactions
R8963	T13803	T13804	nsubj	?,denotes
R8964	T13805	T13804	dobj	uncertainty,denotes
R8965	T13806	T13805	prep	over,uncertainty
R8966	T13807	T13808	det	the,identity
R8967	T13808	T13806	pobj	identity,over
R8968	T13809	T13808	prep	of,identity
R8969	T13810	T13811	det	a,homologue
R8970	T13811	T13809	pobj	homologue,of
R8971	T13812	T13811	amod	functional,homologue
R8972	T13813	T13811	compound	vertebrate,homologue
R8973	T13814	T13804	punct	.,denotes
R8974	T13816	T13817	prep	In,denotes
R8975	T13818	T13816	pobj	C,In
R8976	T13819	T13818	punct	", ",C
R8977	T13820	T13818	conj	D,C
R8978	T13821	T13820	cc	and,D
R8979	T13822	T13820	conj	E,D
R8980	T13823	T13817	punct	", ",denotes
R8981	T13824	T13825	punct	','
R8982	T13825	T13817	nsubj	',denotes
R8983	T13826	T13825	punct	*,'
R8984	T13827	T13828	nummod	one,members
R8985	T13828	T13817	dobj	members,denotes
R8986	T13829	T13827	cc	or,one
R8987	T13830	T13827	conj	more,one
R8988	T13831	T13828	prep	of,members
R8989	T13832	T13833	det	the,family
R8990	T13833	T13831	pobj	family,of
R8991	T13834	T13833	nmod	TACC,family
R8992	T13835	T13834	cc	or,TACC
R8993	T13836	T13837	compound	Aurora,kinase
R8994	T13837	T13834	conj	kinase,TACC
R8995	T13838	T13817	punct	.,denotes
R8999	T13879	T13878	pobj	RXRβ3,of
R9000	T13880	T13879	cc	and,RXRβ3
R9001	T13881	T13879	conj	TACC2s,RXRβ3
R9002	T13882	T13877	punct	.,interaction
R9003	T13884	T13885	amod	Top,panel
R9004	T13885	T13886	dep	panel,Autoradiograph
R9005	T13886	T13888	dep	Autoradiograph,input
R9006	T13887	T13886	punct	: ,Autoradiograph
R9007	T13889	T13886	prep	of,Autoradiograph
R9008	T13890	T13891	nummod	12,%
R9009	T13891	T13892	compound	%,SDS
R9010	T13892	T13893	compound	SDS,gel
R9011	T13893	T13889	pobj	gel,of
R9012	T13894	T13893	compound	polyacrylamide,gel
R9013	T13895	T13886	prep	with,Autoradiograph
R9014	T13896	T13897	advmod	in,vitro
R9015	T13897	T13898	advmod	vitro,translated
R9016	T13898	T13899	amod	translated,construct
R9017	T13899	T13895	pobj	construct,with
R9018	T13900	T13899	compound	RXRβ3,construct
R9019	T13901	T13899	acl	pulled,construct
R9020	T13902	T13901	prt	down,pulled
R9021	T13903	T13901	prep	with,pulled
R9022	T13904	T13905	compound	GST,TACC2
R9023	T13905	T13903	pobj	TACC2,with
R9024	T13906	T13905	punct	-,TACC2
R9025	T13907	T13908	punct	(,Lane
R9026	T13908	T13905	parataxis	Lane,TACC2
R9027	T13909	T13908	nummod	1,Lane
R9028	T13910	T13908	punct	),Lane
R9029	T13911	T13905	cc	or,TACC2
R9030	T13912	T13905	conj	GST,TACC2
R9031	T13913	T13914	punct	(,Lane
R9032	T13914	T13912	parataxis	Lane,GST
R9033	T13915	T13914	nummod	2,Lane
R9034	T13916	T13914	punct	),Lane
R9035	T13917	T13888	punct	;,input
R9036	T13918	T13888	dep	Lane,input
R9037	T13919	T13918	nummod	3,Lane
R9038	T13920	T13888	punct	: ,input
R9039	T13921	T13888	nummod	5,input
R9040	T13922	T13888	compound	%,input
R9041	T13923	T13888	prep	of,input
R9042	T13924	T13925	advmod	in,vitro
R9043	T13925	T13926	amod	vitro,protein
R9044	T13926	T13923	pobj	protein,of
R9045	T13927	T13926	amod	translated,protein
R9046	T13928	T13929	compound	RXR,β
R9047	T13929	T13926	compound	β,protein
R9048	T13930	T13929	punct	-,β
R9049	T13931	T13888	punct	.,input
R9050	T13933	T13934	amod	Bottom,panels
R9051	T13934	T13936	nsubj	panels,represent
R9052	T13935	T13934	nummod	two,panels
R9053	T13937	T13938	nmod	Coomassie,gels
R9054	T13938	T13936	dobj	gels,represent
R9055	T13939	T13940	amod	blue,stained
R9056	T13940	T13938	amod	stained,gels
R9057	T13941	T13938	prep	of,gels
R9058	T13942	T13943	amod	pull,experiment
R9059	T13943	T13941	pobj	experiment,of
R9060	T13944	T13942	prt	down,pull
R9061	T13945	T13943	acl	showing,experiment
R9062	T13946	T13945	dobj	loading,showing
R9063	T13947	T13946	prep	of,loading
R9064	T13948	T13949	compound	GST,TACC2
R9065	T13949	T13947	pobj	TACC2,of
R9066	T13950	T13949	punct	-,TACC2
R9067	T13951	T13949	cc	and,TACC2
R9068	T13952	T13949	conj	GST,TACC2
R9069	T13953	T13936	punct	.,represent
R811	T1593	T1594	advmod	In,silico
R812	T1594	T1595	amod	silico,identification
R813	T1596	T1595	prep	of,identification
R814	T1597	T1598	compound	TACC,members
R815	T1598	T1596	pobj	members,of
R816	T1599	T1598	compound	family,members
R817	T1600	T1598	prep	from,members
R818	T1601	T1602	nmod	vertebrate,lineages
R819	T1602	T1600	pobj	lineages,from
R820	T1603	T1601	cc	and,vertebrate
R821	T1604	T1601	conj	invertebrate,vertebrate
R822	T1606	T1607	compound	Sequence,similarity
R823	T1607	T1608	compound	similarity,searches
R824	T1608	T1609	nsubjpass	searches,performed
R825	T1610	T1608	prep	of,searches
R826	T1611	T1612	det	the,databases
R827	T1612	T1610	pobj	databases,of
R828	T1613	T1614	advmod	publicly,available
R829	T1614	T1612	amod	available,databases
R830	T1615	T1612	compound	genome,databases
R831	T1616	T1612	prep	with,databases
R832	T1617	T1618	det	the,programs
R833	T1618	T1616	pobj	programs,with
R834	T1619	T1618	nmod	BLAST,programs
R835	T1620	T1619	cc	and,BLAST
R836	T1621	T1619	conj	TBLAST,BLAST
R837	T1622	T1609	auxpass	were,performed
R838	T1623	T1624	aux	to,identify
R839	T1624	T1609	advcl	identify,performed
R840	T1625	T1626	nmod	TACC,orthologues
R841	T1626	T1624	dobj	orthologues,identify
R842	T1627	T1625	cc	and,TACC
R843	T1628	T1625	conj	RHAMM,TACC
R844	T1629	T1626	punct	", ",orthologues
R845	T1630	T1626	cc	and,orthologues
R846	T1631	T1632	amod	other,members
R847	T1632	T1626	conj	members,orthologues
R848	T1633	T1632	prep	of,members
R849	T1634	T1635	det	the,superfamily
R850	T1635	T1633	pobj	superfamily,of
R851	T1636	T1637	amod	coiled,coil
R852	T1637	T1635	compound	coil,superfamily
R853	T1638	T1624	prep	in,identify
R854	T1639	T1640	det	a,set
R855	T1640	T1638	pobj	set,in
R856	T1641	T1640	amod	diverse,set
R857	T1642	T1640	prep	of,set
R858	T1643	T1642	pobj	species,of
R859	T1644	T1645	punct	(,Fig.
R860	T1645	T1624	parataxis	Fig.,identify
R861	T1646	T1645	nummod	1,Fig.
R862	T1647	T1645	punct	),Fig.
R863	T1648	T1609	punct	.,performed
R864	T1650	T1651	nsubj	This,identified
R865	T1652	T1653	det	the,sequence
R866	T1653	T1651	dobj	sequence,identified
R867	T1654	T1653	amod	complete,sequence
R868	T1655	T1653	prep	of,sequence
R869	T1656	T1657	det	the,genes
R870	T1657	T1655	pobj	genes,of
R871	T1658	T1657	compound	TACC,genes
R872	T1659	T1651	prep	in,identified
R873	T1660	T1659	pobj	representatives,in
R874	T1661	T1660	prep	of,representatives
R875	T1662	T1663	nummod	five,clades
R876	T1663	T1661	pobj	clades,of
R877	T1664	T1663	amod	major,clades
R878	T1665	T1666	advmod	phylogenetically,distinct
R879	T1666	T1663	amod	distinct,clades
R880	T1667	T1651	punct	.,identified
R881	T1669	T1670	advmod	Where,possible
R882	T1670	T1671	advcl	possible,confirmed
R883	T1672	T1671	punct	", ",confirmed
R884	T1673	T1674	det	the,construction
R885	T1674	T1671	nsubjpass	construction,confirmed
R886	T1675	T1674	prep	of,construction
R887	T1676	T1677	det	the,sequences
R888	T1677	T1675	pobj	sequences,of
R889	T1678	T1677	compound	TACC,sequences
R890	T1679	T1677	prep	from,sequences
R891	T1680	T1681	det	these,organisms
R892	T1681	T1679	pobj	organisms,from
R893	T1682	T1671	auxpass	was,confirmed
R894	T1683	T1671	advmod	also,confirmed
R895	T1684	T1671	agent	by,confirmed
R896	T1685	T1686	det	the,analysis
R897	T1686	T1684	pobj	analysis,by
R898	T1687	T1686	prep	of,analysis
R899	T1688	T1689	det	the,databases
R900	T1689	T1687	pobj	databases,of
R901	T1690	T1689	compound	cDNA,databases
R902	T1691	T1671	punct	.,confirmed
R903	T1693	T1694	amod	Several,sequences
R904	T1694	T1696	nsubjpass	sequences,identified
R905	T1695	T1694	amod	partial,sequences
R906	T1697	T1694	prep	in,sequences
R907	T1698	T1699	amod	other,species
R908	T1699	T1697	pobj	species,in
R909	T1700	T1699	compound	vertebrate,species
R910	T1701	T1699	punct	", ",species
R911	T1702	T1703	det	the,echinodermate
R912	T1703	T1699	appos	echinodermate,species
R913	T1704	T1705	compound	Strongylocentrotus,purpuratus
R914	T1705	T1703	appos	purpuratus,echinodermate
R915	T1706	T1703	cc	and,echinodermate
R916	T1707	T1708	det	the,insect
R917	T1708	T1703	conj	insect,echinodermate
R918	T1709	T1708	compound	protostome,insect
R919	T1710	T1711	compound	Anopheles,gambiae
R920	T1711	T1708	appos	gambiae,insect
R921	T1712	T1696	auxpass	were,identified
R922	T1713	T1696	advmod	also,identified
R923	T1714	T1696	punct	", ",identified
R924	T1715	T1696	advcl	suggesting,identified
R925	T1716	T1717	det	an,conservation
R926	T1717	T1715	dobj	conservation,suggesting
R927	T1718	T1717	amod	ancient,conservation
R928	T1719	T1717	prep	of,conservation
R929	T1720	T1721	det	the,genes
R930	T1721	T1719	pobj	genes,of
R931	T1722	T1721	compound	TACC,genes
R932	T1723	T1717	prep	in,conservation
R933	T1724	T1725	compound	metazoan,lineages
R934	T1725	T1723	pobj	lineages,in
R935	T1726	T1696	punct	.,identified
R936	T1728	T1729	advmod	However,undertaken
R937	T1730	T1729	punct	", ",undertaken
R938	T1731	T1729	prep	due,undertaken
R939	T1732	T1731	pcomp	to,due
R940	T1733	T1734	det	the,infancy
R941	T1734	T1731	pobj	infancy,due
R942	T1735	T1734	amod	relative,infancy
R943	T1736	T1734	prep	of,infancy
R944	T1737	T1738	det	the,projects
R945	T1738	T1736	pobj	projects,of
R946	T1739	T1740	compound	cDNA,genome
R947	T1740	T1738	compound	genome,projects
R948	T1741	T1740	punct	/,genome
R949	T1742	T1738	prep	for,projects
R950	T1743	T1744	det	these,organisms
R951	T1744	T1742	pobj	organisms,for
R952	T1745	T1744	amod	latter,organisms
R953	T1746	T1729	punct	", ",undertaken
R954	T1747	T1748	amod	complete,characterization
R955	T1748	T1729	nsubjpass	characterization,undertaken
R956	T1749	T1748	prep	of,characterization
R957	T1750	T1751	det	these,genes
R958	T1751	T1749	pobj	genes,of
R959	T1752	T1751	compound	TACC,genes
R960	T1753	T1729	aux	could,undertaken
R961	T1754	T1729	neg	not,undertaken
R962	T1755	T1729	auxpass	be,undertaken
R963	T1756	T1729	punct	.,undertaken
R964	T1758	T1759	det	No,conclusion
R965	T1759	T1760	nsubjpass	conclusion,made
R966	T1761	T1760	aux	could,made
R967	T1762	T1760	auxpass	be,made
R968	T1763	T1760	prep	about,made
R969	T1764	T1765	det	the,existence
R970	T1765	T1763	pobj	existence,about
R971	T1766	T1765	prep	of,existence
R972	T1767	T1768	npadvmod	TACC,like
R973	T1768	T1770	amod	like,sequence
R974	T1769	T1768	punct	-,like
R975	T1770	T1766	pobj	sequence,of
R976	T1771	T1765	prep	in,existence
R977	T1772	T1773	amod	non-bilaterian,metazoans
R978	T1773	T1771	pobj	metazoans,in
R979	T1774	T1773	punct	", ",metazoans
R980	T1775	T1776	amod	such,as
R981	T1776	T1773	prep	as,metazoans
R982	T1777	T1776	pobj	Cnidaria,as
R983	T1778	T1777	cc	or,Cnidaria
R984	T1779	T1777	conj	Porifera,Cnidaria
R985	T1780	T1760	punct	", ",made
R986	T1781	T1760	prep	due,made
R987	T1782	T1781	pcomp	to,due
R988	T1783	T1784	det	the,paucity
R989	T1784	T1781	pobj	paucity,due
R990	T1785	T1784	prep	of,paucity
R991	T1786	T1787	compound	sequence,information
R992	T1787	T1785	pobj	information,of
R993	T1788	T1787	prep	for,information
R994	T1789	T1790	det	these,organisms
R995	T1790	T1788	pobj	organisms,for
R996	T1791	T1760	punct	", ",made
R997	T1792	T1760	cc	and,made
R998	T1793	T1794	amod	additional,sequences
R999	T1794	T1796	nsubjpass	sequences,found
R1000	T1795	T1794	amod	definitive,sequences
R1001	T1796	T1760	conj	found,made
R1002	T1797	T1794	prep	with,sequences
R1003	T1798	T1799	det	a,domain
R1004	T1799	T1797	pobj	domain,with
R1005	T1800	T1799	amod	defined,domain
R1006	T1801	T1799	compound	TACC,domain
R1007	T1802	T1796	aux	could,found
R1008	T1803	T1796	neg	not,found
R1009	T1804	T1796	auxpass	be,found
R1025	T1845	T1833	prep	in,identified
R1026	T1846	T1847	det	the,genome
R1027	T1847	T1845	pobj	genome,in
R1028	T1848	T1847	prep	of,genome
R1029	T1849	T1850	det	the,urochordate
R1030	T1850	T1848	pobj	urochordate,of
R1031	T1851	T1852	compound	Ciona,intestinalis
R1032	T1852	T1850	appos	intestinalis,urochordate
R1033	T1853	T1854	punct	[,11
R1034	T1854	T1850	parataxis	11,urochordate
R1035	T1855	T1854	punct	],11
R1036	T1856	T1847	punct	", ",genome
R1037	T1857	T1847	cc	and,genome
R1038	T1858	T1859	det	a,sequence
R1039	T1859	T1847	conj	sequence,genome
R1040	T1860	T1859	amod	partial,sequence
R1041	T1861	T1859	compound	TACC,sequence
R1042	T1862	T1859	prep	from,sequence
R1043	T1863	T1864	det	an,analysis
R1044	T1864	T1862	pobj	analysis,from
R1045	T1865	T1864	prep	of,analysis
R1046	T1866	T1867	det	the,database
R1047	T1867	T1865	pobj	database,of
R1048	T1868	T1869	compound	Halocynthia,rortezi
R1049	T1869	T1867	compound	rortezi,database
R1050	T1870	T1867	compound	EST,database
R1051	T1871	T1872	punct	[,12
R1052	T1872	T1864	parataxis	12,analysis
R1053	T1873	T1872	punct	],12
R1054	T1874	T1833	punct	.,identified
R1055	T1876	T1877	nsubj	This,confirms
R1056	T1878	T1879	det	the,assumption
R1057	T1879	T1877	dobj	assumption,confirms
R1058	T1880	T1879	amod	original,assumption
R1059	T1881	T1882	mark	that,was
R1060	T1882	T1879	acl	was,assumption
R1061	T1883	T1884	det	a,gene
R1062	T1884	T1882	nsubj	gene,was
R1063	T1885	T1884	amod	single,gene
R1064	T1886	T1884	compound	TACC,gene
R1065	T1887	T1882	acomp	present,was
R1066	T1888	T1882	prep	in,was
R1067	T1889	T1890	det	the,ancestor
R1068	T1890	T1888	pobj	ancestor,in
R1069	T1891	T1890	compound	chordate,ancestor
R1070	T1892	T1877	punct	.,confirms
R1071	T1894	T1895	det	The,event
R1072	T1895	T1898	nsubjpass	event,suggested
R1073	T1896	T1895	amod	next,event
R1074	T1897	T1895	amod	major,event
R1075	T1899	T1895	prep	in,event
R1076	T1900	T1901	det	the,evolution
R1077	T1901	T1899	pobj	evolution,in
R1078	T1902	T1901	prep	of,evolution
R1079	T1903	T1904	det	the,genome
R1080	T1904	T1902	pobj	genome,of
R1081	T1905	T1904	compound	chordate,genome
R1082	T1906	T1898	aux	has,suggested
R1083	T1907	T1898	auxpass	been,suggested
R1084	T1908	T1909	aux	to,occurred
R1085	T1909	T1898	xcomp	occurred,suggested
R1086	T1910	T1909	aux	have,occurred
R1087	T1911	T1912	quantmod	687,155.7
R1088	T1912	T1914	nummod	155.7,years
R1089	T1913	T1912	punct	±,155.7
R1090	T1914	T1916	npadvmod	years,ago
R1091	T1915	T1914	nummod	million,years
R1092	T1916	T1909	advmod	ago,occurred
R1093	T1917	T1918	punct	(,MYA
R1094	T1918	T1916	parataxis	MYA,ago
R1095	T1919	T1918	punct	),MYA
R1096	T1920	T1909	punct	", ",occurred
R1097	T1921	T1909	prep	with,occurred
R1098	T1922	T1923	det	the,duplication
R1099	T1923	T1921	pobj	duplication,with
R1100	T1924	T1923	amod	first,duplication
R1101	T1925	T1923	prep	of,duplication
R1102	T1926	T1927	det	the,genome
R1103	T1927	T1925	pobj	genome,of
R1104	T1928	T1927	compound	chordate,genome
R1105	T1929	T1923	punct	", ",duplication
R1106	T1930	T1923	cc	and,duplication
R1107	T1931	T1932	det	a,duplication
R1108	T1932	T1923	conj	duplication,duplication
R1109	T1933	T1932	amod	second,duplication
R1110	T1934	T1932	acl	occurring,duplication
R1111	T1935	T1936	advmod	shortly,thereafter
R1112	T1936	T1934	advmod	thereafter,occurring
R1113	T1937	T1898	punct	.,suggested
R1114	T1939	T1940	advmod	Thus,expect
R1115	T1941	T1940	punct	", ",expect
R1116	T1942	T1943	mark	if,duplicated
R1117	T1943	T1940	advcl	duplicated,expect
R1118	T1944	T1945	det	the,genes
R1119	T1945	T1943	nsubjpass	genes,duplicated
R1120	T1946	T1945	compound	TACC,genes
R1121	T1947	T1943	auxpass	were,duplicated
R1122	T1948	T1943	prep	at,duplicated
R1123	T1949	T1950	det	both,events
R1124	T1950	T1948	pobj	events,at
R1125	T1951	T1940	punct	", ",expect
R1126	T1952	T1940	nsubj	we,expect
R1127	T1953	T1940	aux	would,expect
R1128	T1954	T1955	aux	to,identify
R1129	T1955	T1940	xcomp	identify,expect
R1130	T1956	T1957	nummod	four,genes
R1131	T1957	T1955	dobj	genes,identify
R1132	T1958	T1957	compound	TACC,genes
R1133	T1959	T1955	prep	in,identify
R1134	T1960	T1961	det	the,genome
R1135	T1961	T1959	pobj	genome,in
R1136	T1962	T1963	amod	most,primitive
R1137	T1963	T1961	amod	primitive,genome
R1138	T1964	T1963	punct	"""",primitive
R1139	T1965	T1963	punct	"""",primitive
R1140	T1966	T1961	amod	compact,genome
R1141	T1967	T1961	compound	vertebrate,genome
R1142	T1968	T1961	acl	sequenced,genome
R1143	T1969	T1961	prep	to,genome
R1144	T1970	T1969	pobj	date,to
R1145	T1971	T1961	punct	", ",genome
R1146	T1972	T1973	det	the,pufferfish
R1147	T1973	T1961	appos	pufferfish,genome
R1148	T1974	T1975	compound	Takifugu,rubripes
R1149	T1975	T1973	appos	rubripes,pufferfish
R1150	T1976	T1973	punct	", ",pufferfish
R1151	T1977	T1973	prep	with,pufferfish
R1152	T1978	T1979	nummod	three,genes
R1153	T1979	T1977	pobj	genes,with
R1154	T1980	T1979	acl	corresponding,genes
R1155	T1981	T1980	prep	to,corresponding
R1156	T1982	T1983	det	the,TACC1
R1157	T1983	T1981	pobj	TACC1,to
R1158	T1984	T1983	amod	human,TACC1
R1159	T1985	T1983	punct	-,TACC1
R1160	T1986	T1983	nummod	3,TACC1
R1161	T1987	T1979	punct	", ",genes
R1162	T1988	T1979	cc	and,genes
R1163	T1989	T1979	punct	", ",genes
R1164	T1990	T1991	prep	in,gene
R1165	T1991	T1979	conj	gene,genes
R1166	T1992	T1990	pobj	keeping,in
R1167	T1993	T1992	prep	with,keeping
R1168	T1994	T1995	det	the,model
R1169	T1995	T1993	pobj	model,with
R1170	T1996	T1995	amod	proposed,model
R1171	T1997	T1995	prep	for,model
R1172	T1998	T1999	amod	genomic,duplication
R1173	T1999	T1997	pobj	duplication,for
R1174	T2000	T1999	prep	of,duplication
R1175	T2001	T2002	det	the,loci
R1176	T2002	T2000	pobj	loci,of
R1177	T2003	T2002	amod	chromosomal,loci
R1178	T2004	T1995	prep	for,model
R1179	T2005	T2006	det	the,genes
R1180	T2006	T2004	pobj	genes,for
R1181	T2007	T2006	compound	TACC,genes
R1182	T2008	T2009	punct	(,discussed
R1183	T2009	T1995	parataxis	discussed,model
R1184	T2010	T2009	advmod	below,discussed
R1185	T2011	T2009	punct	),discussed
R1186	T2012	T1991	punct	", ",gene
R1187	T2013	T1991	det	a,gene
R1188	T2014	T1991	amod	possible,gene
R1189	T2015	T1991	amod	fourth,gene
R1190	T2016	T1991	acl	deriving,gene
R1191	T2017	T2016	prep	from,deriving
R1192	T2018	T2019	det	the,ancestor
R1193	T2019	T2017	pobj	ancestor,from
R1194	T2020	T2019	compound	TACC3,ancestor
R1195	T2021	T1940	punct	.,expect
R1196	T2023	T2024	advmod	Indeed,identified
R1197	T2025	T2024	punct	", ",identified
R1198	T2026	T2027	nummod	four,genes
R1199	T2027	T2024	nsubjpass	genes,identified
R1200	T2028	T2027	compound	TACC,genes
R1201	T2029	T2024	auxpass	were,identified
R1202	T2030	T2024	prep	in,identified
R1203	T2031	T2032	compound	T.,rubripes
R1204	T2032	T2030	pobj	rubripes,in
R1205	T2033	T2024	punct	.,identified
R1206	T2035	T2036	prep	Of,corresponded
R1207	T2037	T2035	pobj	these,Of
R1208	T2038	T2036	punct	", ",corresponded
R1209	T2039	T2040	nummod	two,genes
R1210	T2040	T2036	nsubj	genes,corresponded
R1211	T2041	T2036	prep	to,corresponded
R1212	T2042	T2043	det	the,orthologues
R1213	T2043	T2041	pobj	orthologues,to
R1214	T2044	T2045	compound	T.,rubripes
R1215	T2045	T2043	compound	rubripes,orthologues
R1216	T2046	T2043	prep	of,orthologues
R1217	T2047	T2048	amod	human,TACC2
R1218	T2048	T2046	pobj	TACC2,of
R1219	T2049	T2048	cc	and,TACC2
R1220	T2050	T2048	conj	TACC3,TACC2
R1221	T2051	T2036	punct	.,corresponded
R1222	T2053	T2054	advmod	However,are
R1223	T2055	T2054	punct	", ",are
R1224	T2056	T2057	det	the,genes
R1225	T2057	T2054	nsubj	genes,are
R1226	T2058	T2057	amod	other,genes
R1227	T2059	T2057	nummod	two,genes
R1228	T2060	T2057	punct	", ",genes
R1229	T2061	T2057	appos	trTACC1A,genes
R1230	T2062	T2061	cc	and,trTACC1A
R1231	T2063	T2061	conj	trTACC1B,trTACC1A
R1232	T2064	T2054	advmod	clearly,are
R1233	T2065	T2066	advmod	most,related
R1234	T2066	T2054	acomp	related,are
R1235	T2067	T2066	prep	to,related
R1236	T2068	T2067	pobj	TACC1,to
R1237	T2069	T2070	punct	(,Fig.
R1238	T2070	T2054	parataxis	Fig.,are
R1239	T2071	T2070	nummod	1,Fig.
R1240	T2072	T2070	punct	),Fig.
R1241	T2073	T2054	punct	.,are
R1242	T2075	T2076	mark	Although,is
R1243	T2076	T2078	advcl	is,encodes
R1244	T2077	T2076	nsubj	trTACC1A,is
R1245	T2079	T2080	advmod	highly,homologous
R1246	T2080	T2076	acomp	homologous,is
R1247	T2081	T2080	prep	to,homologous
R1248	T2082	T2081	pobj	trTACC1B,to
R1249	T2083	T2078	punct	", ",encodes
R1250	T2084	T2085	det	the,latter
R1251	T2085	T2078	nsubj	latter,encodes
R1252	T2086	T2087	det	a,protein
R1253	T2087	T2078	dobj	protein,encodes
R1254	T2088	T2089	advmod	significantly,smaller
R1255	T2089	T2087	amod	smaller,protein
R1256	T2090	T2087	amod	predicted,protein
R1257	T2091	T2078	punct	.,encodes
R1258	T2093	T2094	det	The,gene
R1259	T2094	T2096	nsubjpass	gene,encoded
R1260	T2095	T2094	compound	trTACC1B,gene
R1261	T2097	T2096	auxpass	is,encoded
R1262	T2098	T2096	agent	by,encoded
R1263	T2099	T2100	nummod	15,exons
R1264	T2100	T2098	pobj	exons,by
R1265	T2101	T2096	prep	over,encoded
R1266	T2102	T2103	advmod	approximately,7
R1267	T2103	T2104	nummod	7,kb
R1268	T2104	T2101	pobj	kb,over
R1269	T2105	T2104	prep	of,kb
R1270	T2106	T2107	det	the,Scaffold
R1271	T2107	T2105	pobj	Scaffold,of
R1272	T2108	T2107	compound	Takifugu,Scaffold
R1273	T2109	T2107	nummod	191,Scaffold
R1274	T2110	T2111	punct	(,see
R1275	T2111	T2096	parataxis	see,encoded
R1276	T2112	T2111	advmod	below,see
R1277	T2113	T2111	punct	),see
R1278	T2114	T2096	punct	.,encoded
R1279	T2116	T2117	det	A,search
R1280	T2117	T2118	nsubj	search,failed
R1281	T2119	T2117	prep	of,search
R1282	T2120	T2121	det	this,region
R1283	T2121	T2119	pobj	region,of
R1284	T2122	T2117	acl	using,search
R1285	T2123	T2124	det	the,software
R1286	T2124	T2122	dobj	software,using
R1287	T2125	T2126	nmod	trTACC1A,sequence
R1288	T2126	T2124	nmod	sequence,software
R1289	T2127	T2126	cc	and,sequence
R1290	T2128	T2129	compound	gene,prediction
R1291	T2129	T2126	conj	prediction,sequence
R1292	T2130	T2118	aux	has,failed
R1293	T2131	T2132	advmod	so,far
R1294	T2132	T2118	advmod	far,failed
R1295	T2133	T2134	aux	to,identify
R1296	T2134	T2118	xcomp	identify,failed
R1297	T2135	T2136	amod	additional,exons
R1298	T2136	T2134	dobj	exons,identify
R1299	T2137	T2136	prep	of,exons
R1300	T2138	T2137	pobj	trTACC1B,of
R1301	T2139	T2118	punct	.,failed
R1302	T2141	T2142	advmod	However,appears
R1303	T2143	T2142	punct	", ",appears
R1304	T2144	T2142	prep	given,appears
R1305	T2145	T2146	det	the,structure
R1306	T2146	T2144	pobj	structure,given
R1307	T2147	T2148	compound	intron,exon
R1308	T2148	T2146	compound	exon,structure
R1309	T2149	T2148	punct	/,exon
R1310	T2150	T2146	prep	of,structure
R1311	T2151	T2152	det	this,gene
R1312	T2152	T2150	pobj	gene,of
R1313	T2153	T2154	advmod	apparently,complete
R1314	T2154	T2152	amod	complete,gene
R1315	T2155	T2142	punct	", ",appears
R1316	T2156	T2142	nsubj	it,appears
R1317	T2157	T2142	oprd	likely,appears
R1318	T2158	T2159	mark	that,is
R1319	T2159	T2142	ccomp	is,appears
R1320	T2160	T2159	nsubj	trTACC1B,is
R1321	T2161	T2159	acomp	active,is
R1322	T2162	T2159	prep	in,is
R1323	T2163	T2164	det	the,pufferfish
R1324	T2164	T2162	pobj	pufferfish,in
R1325	T2165	T2159	punct	", ",is
R1326	T2166	T2159	cc	and,is
R1327	T2167	T2168	advmod	presumably,fulfils
R1328	T2168	T2159	conj	fulfils,is
R1329	T2169	T2170	preconj	either,function
R1330	T2170	T2168	dobj	function,fulfils
R1331	T2171	T2170	det	a,function
R1332	T2172	T2173	amod	temporal,spatial
R1333	T2173	T2170	amod	spatial,function
R1334	T2174	T2173	punct	-,spatial
R1335	T2175	T2170	amod	specific,function
R1336	T2176	T2170	prep	within,function
R1337	T2177	T2178	det	the,organism
R1338	T2178	T2176	pobj	organism,within
R1339	T2179	T2170	punct	", ",function
R1340	T2180	T2170	cc	or,function
R1341	T2181	T2182	det	a,function
R1342	T2182	T2170	conj	function,function
R1343	T2183	T2182	amod	distinct,function
R1344	T2184	T2182	prep	from,function
R1345	T2185	T2186	det	the,product
R1346	T2186	T2184	pobj	product,from
R1347	T2187	T2186	amod	larger,product
R1348	T2188	T2186	compound	trTACC1A,product
R1349	T2189	T2182	prep	within,function
R1350	T2190	T2191	det	the,cell
R1351	T2191	T2189	pobj	cell,within
R1352	T2192	T2142	punct	.,appears
R1353	T2194	T2195	advmod	Thus,appear
R1354	T2196	T2195	punct	", ",appear
R1355	T2197	T2195	prep	based,appear
R1356	T2198	T2197	prep	upon,based
R1357	T2199	T2200	det	the,loci
R1358	T2200	T2198	pobj	loci,upon
R1359	T2201	T2200	amod	surrounding,loci
R1360	T2202	T2200	amod	chromosomal,loci
R1361	T2203	T2204	punct	(,see
R1362	T2204	T2200	parataxis	see,loci
R1363	T2205	T2204	advmod	below,see
R1364	T2206	T2204	punct	),see
R1365	T2207	T2195	punct	", ",appear
R1366	T2208	T2209	det	the,genes
R1367	T2209	T2195	nsubj	genes,appear
R1368	T2210	T2209	nmod	trTACC1A,genes
R1369	T2211	T2210	cc	and,trTACC1A
R1370	T2212	T2210	conj	trTACC1B,trTACC1A
R1371	T2213	T2214	aux	to,arisen
R1372	T2214	T2195	xcomp	arisen,appear
R1373	T2215	T2214	aux	have,arisen
R1374	T2216	T2214	prep	from,arisen
R1375	T2217	T2218	det	the,duplication
R1376	T2218	T2216	pobj	duplication,from
R1377	T2219	T2218	prep	of,duplication
R1378	T2220	T2221	det	the,segment
R1379	T2221	T2219	pobj	segment,of
R1380	T2222	T2221	amod	chromosomal,segment
R1381	T2223	T2221	acl	containing,segment
R1382	T2224	T2225	det	the,ancestor
R1383	T2225	T2223	dobj	ancestor,containing
R1384	T2226	T2225	compound	teleost,ancestor
R1385	T2227	T2225	compound	TACC1,ancestor
R1386	T2228	T2218	punct	", ",duplication
R1387	T2229	T2218	prep	during,duplication
R1388	T2230	T2231	det	the,duplication
R1389	T2231	T2229	pobj	duplication,during
R1390	T2232	T2231	amod	additional,duplication
R1391	T2233	T2231	amod	partial,duplication
R1392	T2234	T2231	amod	genomic,duplication
R1393	T2235	T2236	dep	that,occurred
R1394	T2236	T2231	relcl	occurred,duplication
R1395	T2237	T2236	prep	in,occurred
R1396	T2238	T2239	det	the,lineage
R1397	T2239	T2237	pobj	lineage,in
R1398	T2240	T2239	compound	teleost,lineage
R1399	T2241	T2195	punct	.,appear
R1400	T2243	T2244	advmod	Therefore,support
R1401	T2245	T2244	punct	", ",support
R1402	T2246	T2247	det	this,analysis
R1403	T2247	T2244	nsubj	analysis,support
R1404	T2248	T2247	prep	of,analysis
R1405	T2249	T2250	compound	T.,rubripes
R1406	T2250	T2248	pobj	rubripes,of
R1407	T2251	T2244	aux	does,support
R1408	T2252	T2244	neg	not,support
R1409	T2253	T2254	det	the,hypothesis
R1410	T2254	T2244	dobj	hypothesis,support
R1411	T2255	T2256	mark	that,included
R1412	T2256	T2254	acl	included,hypothesis
R1413	T2257	T2258	det	the,region
R1414	T2258	T2256	nsubjpass	region,included
R1415	T2259	T2258	acl	surrounding,region
R1416	T2260	T2261	det	the,ancestor
R1417	T2261	T2259	dobj	ancestor,surrounding
R1418	T2262	T2261	compound	TACC3,ancestor
R1419	T2263	T2256	auxpass	was,included
R1420	T2264	T2256	prep	in,included
R1421	T2265	T2266	det	the,round
R1422	T2266	T2264	pobj	round,in
R1423	T2267	T2266	amod	second,round
R1424	T2268	T2266	prep	of,round
R1425	T2269	T2270	nmod	vertebrate,duplication
R1426	T2270	T2268	pobj	duplication,of
R1427	T2271	T2270	amod	genomic,duplication
R1428	T2272	T2244	punct	.,support
R1429	T2274	T2275	nsubj	Examination,led
R1430	T2276	T2274	prep	of,Examination
R1431	T2277	T2278	amod	higher,vertebrates
R1432	T2278	T2276	pobj	vertebrates,of
R1433	T2279	T2275	prep	to,led
R1434	T2280	T2281	det	the,identification
R1435	T2281	T2279	pobj	identification,to
R1436	T2282	T2281	prep	of,identification
R1437	T2283	T2284	compound	splice,variants
R1438	T2284	T2282	pobj	variants,of
R1439	T2285	T2284	prep	of,variants
R1440	T2286	T2285	pobj	TACC1,of
R1441	T2287	T2286	cc	and,TACC1
R1442	T2288	T2286	conj	TACC2,TACC1
R1443	T2289	T2281	prep	in,identification
R1444	T2290	T2291	compound	Mus,musculus
R1445	T2291	T2289	pobj	musculus,in
R1446	T2292	T2281	punct	", ",identification
R1447	T2293	T2281	cc	and,identification
R1448	T2294	T2295	det	the,assembly
R1449	T2295	T2281	conj	assembly,identification
R1450	T2296	T2295	prep	of,assembly
R1451	T2297	T2298	det	the,orthologues
R1452	T2298	T2296	pobj	orthologues,of
R1453	T2299	T2300	advmod	previously,unidentified
R1454	T2300	T2298	amod	unidentified,orthologues
R1455	T2301	T2298	prep	of,orthologues
R1456	T2302	T2301	pobj	TACC1,of
R1457	T2303	T2302	punct	-,TACC1
R1458	T2304	T2302	nummod	3,TACC1
R1459	T2305	T2295	prep	from,assembly
R1460	T2306	T2307	compound	Rattus,norvegus
R1461	T2307	T2305	pobj	norvegus,from
R1462	T2308	T2275	punct	.,led
R1463	T2310	T2311	prep	In,found
R1464	T2312	T2310	pobj	addition,In
R1465	T2313	T2311	punct	", ",found
R1466	T2314	T2315	det	the,sequence
R1467	T2315	T2311	nsubjpass	sequence,found
R1468	T2316	T2315	compound	TACC1X,sequence
R1469	T2317	T2311	auxpass	was,found
R1470	T2318	T2311	prep	on,found
R1471	T2319	T2320	compound	mouse,X
R1472	T2320	T2318	pobj	X,on
R1473	T2321	T2320	compound	chromosome,X
R1474	T2322	T2311	punct	.,found
R1475	T2324	T2325	det	This,gene
R1476	T2325	T2326	nsubjpass	gene,related
R1477	T2326	T2329	ccomp	related,revealed
R1478	T2327	T2326	auxpass	is,related
R1479	T2328	T2326	advmod	clearly,related
R1480	T2330	T2326	prep	to,related
R1481	T2331	T2332	det	the,TACC1
R1482	T2332	T2330	pobj	TACC1,to
R1483	T2333	T2332	compound	mouse,TACC1
R1484	T2334	T2329	punct	", ",revealed
R1485	T2335	T2329	advmod	however,revealed
R1486	T2336	T2329	punct	", ",revealed
R1487	T2337	T2338	amod	further,examination
R1488	T2338	T2329	nsubj	examination,revealed
R1489	T2339	T2340	det	a,repeat
R1490	T2340	T2329	dobj	repeat,revealed
R1491	T2341	T2340	compound	mouse,repeat
R1492	T2342	T2340	compound	B1,repeat
R1493	T2343	T2340	acl	distributed,repeat
R1494	T2344	T2343	prep	over,distributed
R1495	T2345	T2346	det	the,length
R1496	T2346	T2344	pobj	length,over
R1497	T2347	T2346	prep	of,length
R1498	T2348	T2349	det	the,intron
R1499	T2349	T2347	pobj	intron,of
R1500	T2350	T2349	amod	proposed,intron
R1501	T2351	T2329	punct	.,revealed
R1502	T2353	T2354	prep	In,detected
R1503	T2355	T2353	pobj	addition,In
R1504	T2356	T2354	punct	", ",detected
R1505	T2357	T2358	det	no,expression
R1506	T2358	T2354	nsubjpass	expression,detected
R1507	T2359	T2358	prep	of,expression
R1508	T2360	T2359	pobj	TACC1X,of
R1509	T2361	T2354	auxpass	was,detected
R1510	T2362	T2354	prep	in,detected
R1511	T2363	T2364	compound	mouse,RNA
R1512	T2364	T2362	pobj	RNA,in
R1513	T2365	T2354	prep	by,detected
R1514	T2366	T2367	compound	rt,PCR
R1515	T2367	T2369	compound	PCR,analysis
R1516	T2368	T2367	punct	-,PCR
R1517	T2369	T2365	pobj	analysis,by
R1518	T2370	T2371	punct	(,shown
R1519	T2371	T2354	parataxis	shown,detected
R1520	T2372	T2371	nsubj	data,shown
R1521	T2373	T2371	neg	not,shown
R1522	T2374	T2371	punct	),shown
R1523	T2375	T2354	punct	", ",detected
R1524	T2376	T2354	advcl	suggesting,detected
R1525	T2377	T2378	mark	that,is
R1526	T2378	T2376	ccomp	is,suggesting
R1527	T2379	T2380	det	this,sequence
R1528	T2380	T2378	nsubj	sequence,is
R1529	T2381	T2382	det	a,pseudogene
R1530	T2382	T2378	attr	pseudogene,is
R1531	T2383	T2382	amod	processed,pseudogene
R1532	T2384	T2354	punct	.,detected
R1533	T2386	T2387	advmod	Similarly,exist
R1534	T2388	T2387	punct	", ",exist
R1535	T2389	T2390	compound	TACC1,pseudogenes
R1536	T2390	T2387	nsubj	pseudogenes,exist
R1537	T2391	T2387	advmod	also,exist
R1538	T2392	T2387	advcl	spread,exist
R1539	T2393	T2392	prep	over,spread
R1540	T2394	T2395	nummod	22,kb
R1541	T2395	T2393	pobj	kb,over
R1542	T2396	T2395	prep	of,kb
R1543	T2397	T2398	det	the,region
R1544	T2398	T2396	pobj	region,of
R1545	T2399	T2398	amod	centromeric,region
R1546	T2400	T2398	prep	of,region
R1547	T2401	T2402	amod	human,chromosome
R1548	T2402	T2400	pobj	chromosome,of
R1549	T2403	T2402	nummod	10,chromosome
R1550	T2404	T2393	cc	and,over
R1551	T2405	T2393	punct	", ",over
R1552	T2406	T2393	conj	in,over
R1553	T2407	T2406	pobj	8q21,in
R1554	T2408	T2407	punct	", ",8q21
R1555	T2409	T2410	det	a,region
R1556	T2410	T2407	appos	region,8q21
R1557	T2411	T2410	amod	shorter,region
R1558	T2412	T2413	nummod	86,%
R1559	T2413	T2414	npadvmod	%,identical
R1560	T2414	T2410	amod	identical,region
R1561	T2415	T2414	prep	to,identical
R1562	T2416	T2417	det	the,bp
R1563	T2417	T2415	pobj	bp,to
R1564	T2418	T2417	amod	final,bp
R1565	T2419	T2417	nummod	359,bp
R1566	T2420	T2417	prep	of,bp
R1567	T2421	T2422	det	the,region
R1568	T2422	T2420	pobj	region,of
R1569	T2423	T2422	nmod	TACC1,region
R1570	T2424	T2422	nummod	3,region
R1571	T2425	T2424	punct	',3
R1572	T2426	T2422	amod	untranslated,region
R1573	T2427	T2387	punct	.,exist
R1574	T2429	T2430	det	No,pseudogenes
R1575	T2430	T2431	nsubjpass	pseudogenes,identified
R1576	T2432	T2430	acl	corresponding,pseudogenes
R1577	T2433	T2432	prep	to,corresponding
R1578	T2434	T2433	pobj	TACC2,to
R1579	T2435	T2434	cc	or,TACC2
R1580	T2436	T2434	conj	TACC3,TACC2
R1581	T2437	T2431	auxpass	were,identified
R1582	T2438	T2431	prep	in,identified
R1583	T2439	T2440	det	any,species
R1584	T2440	T2438	pobj	species,in
R1585	T2441	T2440	amod	mammalian,species
R1586	T2442	T2431	punct	.,identified
R1587	T2678	T2677	prep	of,Characterization
R1588	T2679	T2680	compound	vertebrate,TACC3
R1589	T2680	T2681	compound	TACC3,orthologues
R1590	T2681	T2678	pobj	orthologues,of
R1591	T2683	T2684	prep	Based,is
R1592	T2685	T2683	prep	upon,Based
R1593	T2686	T2687	amod	current,analysis
R1594	T2687	T2685	pobj	analysis,upon
R1595	T2688	T2687	amod	functional,analysis
R1596	T2689	T2684	punct	", ",is
R1597	T2690	T2691	det	the,characterization
R1598	T2691	T2684	nsubj	characterization,is
R1599	T2692	T2691	prep	of,characterization
R1600	T2693	T2694	compound	TACC3,orthologues
R1601	T2694	T2692	pobj	orthologues,of
R1602	T2695	T2684	acomp	likely,is
R1603	T2696	T2697	aux	to,be
R1604	T2697	T2695	xcomp	be,likely
R1605	T2698	T2697	acomp	pivotal,be
R1606	T2699	T2698	prep	to,pivotal
R1607	T2700	T2699	pcomp	understanding,to
R1608	T2701	T2702	det	the,sequence
R1609	T2702	T2700	dobj	sequence,understanding
R1610	T2703	T2702	cc	and,sequence
R1611	T2704	T2705	amod	functional,evolution
R1612	T2705	T2702	conj	evolution,sequence
R1613	T2706	T2702	prep	of,sequence
R1614	T2707	T2708	det	the,family
R1615	T2708	T2706	pobj	family,of
R1616	T2709	T2708	compound	TACC,family
R1617	T2710	T2708	compound	gene,family
R1618	T2711	T2684	punct	.,is
R1619	T2713	T2714	mark	As,indicated
R1620	T2714	T2715	advcl	indicated,duplicated
R1621	T2716	T2714	advmod	below,indicated
R1622	T2717	T2715	punct	", ",duplicated
R1623	T2718	T2719	det	the,region
R1624	T2719	T2715	nsubjpass	region,duplicated
R1625	T2720	T2719	amod	chromosomal,region
R1626	T2721	T2719	acl	containing,region
R1627	T2722	T2723	det	the,precursors
R1628	T2723	T2721	dobj	precursors,containing
R1629	T2724	T2725	compound	TACC,gene
R1630	T2725	T2723	compound	gene,precursors
R1631	T2726	T2715	auxpass	was,duplicated
R1632	T2727	T2715	advmod	twice,duplicated
R1633	T2728	T2715	prep	during,duplicated
R1634	T2729	T2730	compound	vertebrate,evolution
R1635	T2730	T2728	pobj	evolution,during
R1636	T2731	T2715	punct	.,duplicated
R1637	T2733	T2734	mark	Although,suggests
R1638	T2734	T2746	advcl	suggests,excluded
R1639	T2735	T2736	det	the,analysis
R1640	T2736	T2734	nsubj	analysis,suggests
R1641	T2737	T2736	prep	of,analysis
R1642	T2738	T2739	compound	T.,rubripes
R1643	T2739	T2737	pobj	rubripes,of
R1644	T2740	T2739	punct	", ",rubripes
R1645	T2741	T2739	conj	rodents,rubripes
R1646	T2742	T2741	cc	and,rodents
R1647	T2743	T2741	conj	humans,rodents
R1648	T2744	T2745	advmod	so,far
R1649	T2745	T2734	advmod	far,suggests
R1650	T2747	T2748	mark	that,included
R1651	T2748	T2734	ccomp	included,suggests
R1652	T2749	T2750	det	the,precursor
R1653	T2750	T2748	nsubjpass	precursor,included
R1654	T2751	T2750	compound	vertebrate,precursor
R1655	T2752	T2750	compound	TACC3,precursor
R1656	T2753	T2748	auxpass	was,included
R1657	T2754	T2748	neg	not,included
R1658	T2755	T2748	prep	in,included
R1659	T2756	T2757	det	the,round
R1660	T2757	T2755	pobj	round,in
R1661	T2758	T2757	amod	second,round
R1662	T2759	T2757	prep	of,round
R1663	T2760	T2761	amod	genomic,duplication
R1664	T2761	T2759	pobj	duplication,of
R1665	T2762	T2746	punct	", ",excluded
R1666	T2763	T2746	nsubjpass	it,excluded
R1667	T2764	T2746	aux	could,excluded
R1668	T2765	T2746	neg	not,excluded
R1669	T2766	T2746	auxpass	be,excluded
R1670	T2767	T2768	mark	that,lost
R1671	T2768	T2746	ccomp	lost,excluded
R1672	T2769	T2770	det	a,gene
R1673	T2770	T2768	nsubjpass	gene,lost
R1674	T2771	T2770	compound	TACC4,gene
R1675	T2772	T2768	aux	may,lost
R1676	T2773	T2768	aux	have,lost
R1677	T2774	T2768	auxpass	been,lost
R1678	T2775	T2768	prep	during,lost
R1679	T2776	T2777	det	the,evolution
R1680	T2777	T2775	pobj	evolution,during
R1681	T2778	T2777	prep	of,evolution
R1682	T2779	T2780	det	these,lineages
R1683	T2780	T2778	pobj	lineages,of
R1684	T2781	T2746	punct	.,excluded
R1685	T2783	T2784	det	The,cloning
R1686	T2784	T2785	nsubj	cloning,added
R1687	T2786	T2784	prep	of,cloning
R1688	T2787	T2788	det	a,member
R1689	T2788	T2786	pobj	member,of
R1690	T2789	T2788	amod	new,member
R1691	T2790	T2788	prep	of,member
R1692	T2791	T2792	det	the,family
R1693	T2792	T2790	pobj	family,of
R1694	T2793	T2792	compound	TACC,family
R1695	T2794	T2784	prep	in,cloning
R1696	T2795	T2796	compound	Oryctolagus,cuniculus
R1697	T2796	T2794	pobj	cuniculus,in
R1698	T2797	T2785	aux	has,added
R1699	T2798	T2785	prep	to,added
R1700	T2799	T2800	det	this,controversy
R1701	T2800	T2798	pobj	controversy,to
R1702	T2801	T2802	punct	[,9
R1703	T2802	T2785	parataxis	9,added
R1704	T2803	T2802	punct	],9
R1705	T2804	T2785	punct	.,added
R1706	T2806	T2807	advcl	Designated,was
R1707	T2808	T2806	oprd	TACC4,Designated
R1708	T2809	T2807	punct	", ",was
R1709	T2810	T2811	det	the,cDNA
R1710	T2811	T2807	nsubj	cDNA,was
R1711	T2812	T2813	nummod	1.5,kb
R1712	T2813	T2811	compound	kb,cDNA
R1713	T2814	T2815	advmod	highly,related
R1714	T2815	T2807	acomp	related,was
R1715	T2816	T2815	punct	", ",related
R1716	T2817	T2815	cc	but,related
R1717	T2818	T2815	conj	proposed,related
R1718	T2819	T2820	aux	to,be
R1719	T2820	T2818	xcomp	be,proposed
R1720	T2821	T2820	acomp	distinct,be
R1721	T2822	T2821	prep	from,distinct
R1722	T2823	T2822	pobj	TACC3,from
R1723	T2824	T2807	punct	.,was
R1724	T2826	T2827	advmod	However,suggested
R1725	T2828	T2827	punct	", ",suggested
R1726	T2829	T2830	compound	Northern,blot
R1727	T2830	T2831	compound	blot,data
R1728	T2831	T2827	nsubj	data,suggested
R1729	T2832	T2833	mark	that,produces
R1730	T2833	T2827	ccomp	produces,suggested
R1731	T2834	T2835	det	this,gene
R1732	T2835	T2833	nsubj	gene,produces
R1733	T2836	T2837	det	a,transcript
R1734	T2837	T2833	dobj	transcript,produces
R1735	T2838	T2837	amod	single,transcript
R1736	T2839	T2840	nummod	2.3,kb
R1737	T2840	T2837	compound	kb,transcript
R1738	T2841	T2842	punct	[,9
R1739	T2842	T2833	parataxis	9,produces
R1740	T2843	T2842	punct	],9
R1741	T2844	T2833	punct	", ",produces
R1742	T2845	T2833	advcl	indicating,produces
R1743	T2846	T2847	mark	that,was
R1744	T2847	T2845	ccomp	was,indicating
R1745	T2848	T2849	det	the,cDNA
R1746	T2849	T2847	nsubj	cDNA,was
R1747	T2850	T2849	amod	cloned,cDNA
R1748	T2851	T2847	acomp	incomplete,was
R1749	T2852	T2827	punct	.,suggested
R1750	T2854	T2855	det	The,degree
R1751	T2855	T2856	nsubj	degree,suggested
R1752	T2857	T2855	prep	of,degree
R1753	T2858	T2857	pobj	similarity,of
R1754	T2859	T2858	prep	to,similarity
R1755	T2860	T2861	det	the,sequence
R1756	T2861	T2859	pobj	sequence,to
R1757	T2862	T2861	amod	published,sequence
R1758	T2863	T2861	prep	of,sequence
R1759	T2864	T2865	amod	human,TACC3
R1760	T2865	T2863	pobj	TACC3,of
R1761	T2866	T2864	cc	and,human
R1762	T2867	T2864	conj	mouse,human
R1763	T2868	T2856	prep	to,suggested
R1764	T2869	T2868	pobj	us,to
R1765	T2870	T2871	mark	that,represents
R1766	T2871	T2856	ccomp	represents,suggested
R1767	T2872	T2871	nsubj	TACC4,represents
R1768	T2873	T2871	advmod	actually,represents
R1769	T2874	T2875	det	a,cDNA
R1770	T2875	T2871	dobj	cDNA,represents
R1771	T2876	T2875	amod	partial,cDNA
R1772	T2877	T2875	compound	rabbit,cDNA
R1773	T2878	T2875	compound	TACC3,cDNA
R1774	T2879	T2856	punct	.,suggested
R1775	T2881	T2882	aux	To,test
R1776	T2882	T2883	advcl	test,set
R1777	T2884	T2885	det	this,hypothesis
R1778	T2885	T2882	dobj	hypothesis,test
R1779	T2886	T2883	punct	", ",set
R1780	T2887	T2883	nsubj	we,set
R1781	T2888	T2883	prt	out,set
R1782	T2889	T2890	aux	to,clone
R1783	T2890	T2883	xcomp	clone,set
R1784	T2891	T2892	det	the,sequence
R1785	T2892	T2890	dobj	sequence,clone
R1786	T2893	T2892	amod	complete,sequence
R1787	T2894	T2892	compound	rabbit,sequence
R1788	T2895	T2892	compound	TACC3,sequence
R1789	T2896	T2890	punct	", ",clone
R1790	T2897	T2890	prep	based,clone
R1791	T2898	T2897	prep	upon,based
R1792	T2899	T2900	det	the,features
R1793	T2900	T2898	pobj	features,upon
R1794	T2901	T2900	amod	known,features
R1795	T2902	T2900	prep	of,features
R1796	T2903	T2904	amod	human,TACC3
R1797	T2904	T2902	pobj	TACC3,of
R1798	T2905	T2903	cc	and,human
R1799	T2906	T2903	conj	mouse,human
R1800	T2907	T2883	punct	.,set
R1801	T2909	T2910	nsubj	We,noted
R1802	T2911	T2910	aux	have,noted
R1803	T2912	T2910	advmod	previously,noted
R1804	T2913	T2914	mark	that,are
R1805	T2914	T2910	ccomp	are,noted
R1806	T2915	T2916	det	the,regions
R1807	T2916	T2914	nsubj	regions,are
R1808	T2917	T2918	npadvmod	N,terminal
R1809	T2918	T2916	amod	terminal,regions
R1810	T2919	T2918	punct	-,terminal
R1811	T2920	T2918	cc	and,terminal
R1812	T2921	T2922	npadvmod	C,terminal
R1813	T2922	T2918	conj	terminal,terminal
R1814	T2923	T2922	punct	-,terminal
R1815	T2924	T2916	prep	of,regions
R1816	T2925	T2926	det	the,proteins
R1817	T2926	T2924	pobj	proteins,of
R1818	T2927	T2926	amod	human,proteins
R1819	T2928	T2927	cc	and,human
R1820	T2929	T2927	conj	mouse,human
R1821	T2930	T2926	compound	TACC3,proteins
R1822	T2931	T2932	advmod	highly,conserved
R1823	T2932	T2914	acomp	conserved,are
R1824	T2933	T2934	punct	(,2
R1825	T2934	T2910	parataxis	2,noted
R1826	T2935	T2934	punct	[,2
R1827	T2936	T2934	punct	],2
R1828	T2937	T2934	punct	", ",2
R1829	T2938	T2934	advcl	see,2
R1830	T2939	T2938	advmod	below,see
R1831	T2940	T2934	punct	),2
R1832	T2941	T2910	punct	.,noted
R1833	T2943	T2944	advmod	Therefore,designed
R1834	T2945	T2944	punct	", ",designed
R1835	T2946	T2944	prep	based,designed
R1836	T2947	T2946	prep	upon,based
R1837	T2948	T2949	det	the,identity
R1838	T2949	T2947	pobj	identity,upon
R1839	T2950	T2949	compound	sequence,identity
R1840	T2951	T2949	prep	between,identity
R1841	T2952	T2953	det	these,genes
R1842	T2953	T2951	pobj	genes,between
R1843	T2954	T2944	punct	", ",designed
R1844	T2955	T2944	nsubj	we,designed
R1845	T2956	T2957	det	a,primer
R1846	T2957	T2944	dobj	primer,designed
R1847	T2958	T2957	compound	consensus,primer
R1848	T2959	T2957	compound	oligonucleotide,primer
R1849	T2960	T2957	punct	", ",primer
R1850	T2961	T2957	appos	T3con2,primer
R1851	T2962	T2957	punct	", ",primer
R1852	T2963	T2964	dep	that,be
R1853	T2964	T2957	relcl	be,primer
R1854	T2965	T2964	aux	would,be
R1855	T2966	T2964	acomp	suitable,be
R1856	T2967	T2966	prep	for,suitable
R1857	T2968	T2969	det	the,identification
R1858	T2969	T2967	pobj	identification,for
R1859	T2970	T2969	prep	of,identification
R1860	T2971	T2972	det	the,region
R1861	T2972	T2970	pobj	region,of
R1862	T2973	T2972	acl	containing,region
R1863	T2974	T2975	det	the,methionine
R1864	T2975	T2973	dobj	methionine,containing
R1865	T2976	T2975	compound	initiator,methionine
R1866	T2977	T2975	prep	of,methionine
R1867	T2978	T2979	det	the,cDNAs
R1868	T2979	T2977	pobj	cDNAs,of
R1869	T2980	T2979	compound	TACC3,cDNAs
R1870	T2981	T2979	prep	from,cDNAs
R1871	T2982	T2981	pobj	primates,from
R1872	T2983	T2982	cc	and,primates
R1873	T2984	T2982	conj	rodents,primates
R1874	T2985	T2944	punct	.,designed
R1875	T2987	T2988	advcl	Using,isolated
R1876	T2989	T2990	det	this,primer
R1877	T2990	T2987	dobj	primer,Using
R1878	T2991	T2987	punct	", ",Using
R1879	T2992	T2987	prep	in,Using
R1880	T2993	T2992	pobj	combination,in
R1881	T2994	T2993	prep	with,combination
R1882	T2995	T2996	det	the,primer
R1883	T2996	T2994	pobj	primer,with
R1884	T2997	T2998	npadvmod	TACC4,specific
R1885	T2998	T2996	amod	specific,primer
R1886	T2999	T2998	punct	-,specific
R1887	T3000	T2996	compound	RACE,primer
R1888	T3001	T2996	punct	(,primer
R1889	T3002	T2996	appos	RACE2,primer
R1890	T3003	T2996	punct	),primer
R1891	T3004	T2996	punct	", ",primer
R1892	T3005	T3006	advmod	initially,used
R1893	T3006	T2996	acl	used,primer
R1894	T3007	T3006	agent	by,used
R1895	T3008	T3007	pobj	Steadman,by
R1896	T3009	T3010	advmod	et,al
R1897	T3010	T3008	advmod	al,Steadman
R1898	T3011	T3012	punct	[,9
R1899	T3012	T3006	parataxis	9,used
R1900	T3013	T3012	punct	],9
R1901	T3014	T2988	punct	", ",isolated
R1902	T3015	T2988	nsubj	we,isolated
R1903	T3016	T3017	det	a,product
R1904	T3017	T2988	dobj	product,isolated
R1905	T3018	T3019	nummod	1.5,kb
R1906	T3019	T3020	compound	kb,PCR
R1907	T3020	T3017	compound	PCR,product
R1908	T3021	T2988	prep	from,isolated
R1909	T3022	T3023	compound	rabbit,cDNA
R1910	T3023	T3021	pobj	cDNA,from
R1911	T3024	T3023	compound	brain,cDNA
R1912	T3025	T2988	prep	by,isolated
R1913	T3026	T3027	compound	rt,PCR
R1914	T3027	T3025	pobj	PCR,by
R1915	T3028	T3027	punct	-,PCR
R1916	T3029	T2988	punct	.,isolated
R1917	T3031	T3032	prep	In,generated
R1918	T3033	T3031	pobj	combination,In
R1919	T3034	T3033	prep	with,combination
R1920	T3035	T3036	nummod	3,RACE
R1921	T3036	T3034	pobj	RACE,with
R1922	T3037	T3035	punct	',3
R1923	T3038	T3032	punct	", ",generated
R1924	T3039	T3032	nsubj	this,generated
R1925	T3040	T3041	det	a,cDNA
R1926	T3041	T3032	dobj	cDNA,generated
R1927	T3042	T3041	compound	consensus,cDNA
R1928	T3043	T3041	prep	of,cDNA
R1929	T3044	T3045	nummod	2283,bp
R1930	T3045	T3043	pobj	bp,of
R1931	T3046	T3047	dep	which,corresponds
R1932	T3047	T3041	relcl	corresponds,cDNA
R1933	T3048	T3047	prep	to,corresponds
R1934	T3049	T3050	det	the,size
R1935	T3050	T3048	pobj	size,to
R1936	T3051	T3050	compound	transcript,size
R1937	T3052	T3050	prep	of,size
R1938	T3053	T3054	nummod	2.3,kb
R1939	T3054	T3052	pobj	kb,of
R1940	T3055	T3050	acl	detected,size
R1941	T3056	T3055	prep	by,detected
R1942	T3057	T3058	det	the,sequence
R1943	T3058	T3056	pobj	sequence,by
R1944	T3059	T3058	punct	"""",sequence
R1945	T3060	T3058	nmod	TACC4,sequence
R1946	T3061	T3058	punct	"""",sequence
R1947	T3062	T3058	acl	reported,sequence
R1948	T3063	T3062	prep	in,reported
R1949	T3064	T3063	pobj	Figure,in
R1950	T3065	T3064	nummod	4,Figure
R1951	T3066	T3064	prep	of,Figure
R1952	T3067	T3066	pobj	Steadman,of
R1953	T3068	T3069	advmod	et,al
R1954	T3069	T3067	advmod	al,Steadman
R1955	T3070	T3071	punct	[,9
R1956	T3071	T3062	parataxis	9,reported
R1957	T3072	T3071	punct	],9
R1958	T3073	T3032	punct	.,generated
R1959	T3075	T3076	advmod	Thus,corresponds
R1960	T3077	T3076	punct	", ",corresponds
R1961	T3078	T3079	mark	while,remains
R1962	T3079	T3076	advcl	remains,corresponds
R1963	T3080	T3079	nsubj	it,remains
R1964	T3081	T3079	oprd	possible,remains
R1965	T3082	T3083	mark	that,is
R1966	T3083	T3079	ccomp	is,remains
R1967	T3084	T3085	det	the,sequence
R1968	T3085	T3083	nsubj	sequence,is
R1969	T3086	T3085	punct	"""",sequence
R1970	T3087	T3085	nmod	TACC4,sequence
R1971	T3088	T3085	punct	"""",sequence
R1972	T3089	T3090	det	an,product
R1973	T3090	T3083	attr	product,is
R1974	T3091	T3090	amod	alternative,product
R1975	T3092	T3090	compound	splice,product
R1976	T3093	T3083	punct	", ",is
R1977	T3094	T3083	cc	or,is
R1978	T3095	T3083	conj	is,is
R1979	T3096	T3097	det	the,product
R1980	T3097	T3095	attr	product,is
R1981	T3098	T3097	prep	of,product
R1982	T3099	T3098	pobj	reduplication,of
R1983	T3100	T3099	prep	of,reduplication
R1984	T3101	T3102	det	the,gene
R1985	T3102	T3100	pobj	gene,of
R1986	T3103	T3102	compound	TACC3,gene
R1987	T3104	T3105	punct	(,events
R1988	T3105	T3095	parataxis	events,is
R1989	T3106	T3107	dep	that,be
R1990	T3107	T3105	relcl	be,events
R1991	T3108	T3107	aux	would,be
R1992	T3109	T3107	acomp	specific,be
R1993	T3110	T3109	prep	to,specific
R1994	T3111	T3112	det	the,rabbit
R1995	T3112	T3110	pobj	rabbit,to
R1996	T3113	T3105	punct	),events
R1997	T3114	T3076	punct	", ",corresponds
R1998	T3115	T3116	det	the,transcript
R1999	T3116	T3076	nsubj	transcript,corresponds
R2000	T3117	T3116	amod	only,transcript
R2001	T3118	T3116	acl	detected,transcript
R2002	T3119	T3118	prep	in,detected
R2003	T3120	T3121	compound	rabbit,RNA
R2004	T3121	T3119	pobj	RNA,in
R2005	T3122	T3076	prep	to,corresponds
R2006	T3123	T3124	det	the,size
R2007	T3124	T3122	pobj	size,to
R2008	T3125	T3124	amod	predicted,size
R2009	T3126	T3124	compound	transcript,size
R2010	T3127	T3124	prep	of,size
R2011	T3128	T3129	det	the,sequence
R2012	T3129	T3127	pobj	sequence,of
R2013	T3130	T3129	compound	TACC3,sequence
R2014	T3131	T3132	dep	that,identified
R2015	T3132	T3124	relcl	identified,size
R2016	T3133	T3132	nsubj	we,identified
R2017	T3134	T3132	aux	have,identified
R2018	T3135	T3132	advmod	here,identified
R2019	T3136	T3076	punct	.,corresponds
R2020	T3138	T3139	advmod	Furthermore,found
R2021	T3140	T3139	punct	", ",found
R2022	T3141	T3142	det	the,string
R2023	T3142	T3139	nsubjpass	string,found
R2024	T3143	T3142	prep	of,string
R2025	T3144	T3143	pobj	nucleotides,of
R2026	T3145	T3144	acl	found,nucleotides
R2027	T3146	T3145	prep	at,found
R2028	T3147	T3148	det	the,end
R2029	T3148	T3146	pobj	end,at
R2030	T3149	T3148	nummod	5,end
R2031	T3150	T3149	punct	',5
R2032	T3151	T3148	prep	of,end
R2033	T3152	T3153	det	the,sequence
R2034	T3153	T3151	pobj	sequence,of
R2035	T3154	T3153	punct	"""",sequence
R2036	T3155	T3153	nmod	TACC4,sequence
R2037	T3156	T3153	punct	"""",sequence
R2038	T3157	T3139	auxpass	is,found
R2039	T3158	T3139	advmod	also,found
R2040	T3159	T3139	prep	at,found
R2041	T3160	T3161	det	the,ends
R2042	T3161	T3159	pobj	ends,at
R2043	T3162	T3161	nummod	5,ends
R2044	T3163	T3162	punct	',5
R2045	T3164	T3161	prep	of,ends
R2046	T3165	T3166	det	a,number
R2047	T3166	T3164	pobj	number,of
R2048	T3167	T3166	prep	of,number
R2049	T3168	T3169	compound	cDNA,sequences
R2050	T3169	T3167	pobj	sequences,of
R2051	T3170	T3169	punct	(,sequences
R2052	T3171	T3172	advmod	e.g.,NM_023500
R2053	T3172	T3169	appos	NM_023500,sequences
R2054	T3173	T3172	nmod	U82468,NM_023500
R2055	T3174	T3172	punct	", ",NM_023500
R2056	T3175	T3169	punct	),sequences
R2057	T3176	T3169	punct	", ",sequences
R2058	T3177	T3178	dep	that,isolated
R2059	T3178	T3169	relcl	isolated,sequences
R2060	T3179	T3178	auxpass	were,isolated
R2061	T3180	T3178	agent	by,isolated
R2062	T3181	T3182	nummod	5,RACE
R2063	T3182	T3180	pobj	RACE,by
R2064	T3183	T3181	punct	',5
R2065	T3184	T3139	punct	", ",found
R2066	T3185	T3139	advcl	suggesting,found
R2067	T3186	T3187	mark	that,correspond
R2068	T3187	T3185	ccomp	correspond,suggesting
R2069	T3188	T3187	nsubj	they,correspond
R2070	T3189	T3187	aux	may,correspond
R2071	T3190	T3187	prep	to,correspond
R2072	T3191	T3192	det	an,artefact
R2073	T3192	T3190	pobj	artefact,to
R2074	T3193	T3192	prep	of,artefact
R2075	T3194	T3195	det	the,methodology
R2076	T3195	T3193	pobj	methodology,of
R2077	T3196	T3195	nummod	5,methodology
R2078	T3197	T3196	punct	',5
R2079	T3198	T3195	compound	RACE,methodology
R2080	T3199	T3195	acl	used,methodology
R2081	T3200	T3199	prep	in,used
R2082	T3201	T3202	poss	their,construction
R2083	T3202	T3200	pobj	construction,in
R2084	T3203	T3139	punct	.,found
R2085	T3205	T3206	det	The,TACC4
R2086	T3206	T3209	nsubjpass	TACC4,found
R2087	T3207	T3206	nmod	rabbit,TACC4
R2088	T3208	T3206	punct	"""",TACC4
R2089	T3210	T3206	punct	"""",TACC4
R2090	T3211	T3206	cc	and,TACC4
R2091	T3212	T3213	det	the,TACC3
R2092	T3213	T3215	compound	TACC3,sequence
R2093	T3214	T3213	compound	rabbit,TACC3
R2094	T3215	T3206	conj	sequence,TACC4
R2095	T3216	T3217	dep	that,isolated
R2096	T3217	T3206	relcl	isolated,TACC4
R2097	T3218	T3217	nsubj	we,isolated
R2098	T3219	T3217	aux	have,isolated
R2099	T3220	T3209	auxpass	are,found
R2100	T3221	T3209	advmod	also,found
R2101	T3222	T3209	prep	on,found
R2102	T3223	T3224	det	the,branch
R2103	T3224	T3222	pobj	branch,on
R2104	T3225	T3224	amod	same,branch
R2105	T3226	T3224	prep	of,branch
R2106	T3227	T3228	det	the,tree
R2107	T3228	T3226	pobj	tree,of
R2108	T3229	T3228	nmod	TACC,tree
R2109	T3230	T3228	amod	phylogenetic,tree
R2110	T3231	T3209	prep	with,found
R2111	T3232	T3233	det	the,orthologues
R2112	T3233	T3231	pobj	orthologues,with
R2113	T3234	T3233	amod	other,orthologues
R2114	T3235	T3233	compound	TACC3,orthologues
R2115	T3236	T3233	punct	", ",orthologues
R2116	T3237	T3233	prep	including,orthologues
R2117	T3238	T3237	pobj	maskin,including
R2118	T3239	T3238	punct	(,maskin
R2119	T3240	T3241	compound	Xenopus,laevis
R2120	T3241	T3238	appos	laevis,maskin
R2121	T3242	T3238	punct	),maskin
R2122	T3243	T3238	punct	", ",maskin
R2123	T3244	T3238	cc	and,maskin
R2124	T3245	T3246	det	the,sequences
R2125	T3246	T3238	conj	sequences,maskin
R2126	T3247	T3248	advmod	newly,identified
R2127	T3248	T3246	amod	identified,sequences
R2128	T3249	T3246	compound	TACC3,sequences
R2129	T3250	T3246	prep	in,sequences
R2130	T3251	T3252	compound	Rattus,norvegus
R2131	T3252	T3250	pobj	norvegus,in
R2132	T3253	T3252	punct	", ",norvegus
R2133	T3254	T3255	compound	Gallus,gallus
R2134	T3255	T3252	conj	gallus,norvegus
R2135	T3256	T3255	punct	", ",gallus
R2136	T3257	T3258	compound	Silurana,tropicalis
R2137	T3258	T3255	conj	tropicalis,gallus
R2138	T3259	T3258	punct	", ",tropicalis
R2139	T3260	T3261	compound	Danio,rerio
R2140	T3261	T3258	conj	rerio,tropicalis
R2141	T3262	T3261	cc	and,rerio
R2142	T3263	T3264	compound	T.,rubripes
R2143	T3264	T3261	conj	rubripes,rerio
R2144	T3265	T3246	punct	", ",sequences
R2145	T3266	T3246	acl	reported,sequences
R2146	T3267	T3266	prep	in,reported
R2147	T3268	T3269	det	this,manuscript
R2148	T3269	T3267	pobj	manuscript,in
R2149	T3270	T3271	punct	(,Fig.
R2150	T3271	T3209	parataxis	Fig.,found
R2151	T3272	T3271	nummod	1,Fig.
R2152	T3273	T3271	punct	),Fig.
R2153	T3274	T3209	punct	.,found
R2154	T3276	T3277	advmod	Thus,is
R2155	T3278	T3277	punct	", ",is
R2156	T3279	T3277	nsubj	it,is
R2157	T3280	T3277	neg	not,is
R2158	T3281	T3277	prep	in,is
R2159	T3282	T3283	det	a,branch
R2160	T3283	T3281	pobj	branch,in
R2161	T3284	T3283	amod	separate,branch
R2162	T3285	T3286	dep	that,expected
R2163	T3286	T3283	relcl	expected,branch
R2164	T3287	T3286	aux	may,expected
R2165	T3288	T3286	auxpass	be,expected
R2166	T3289	T3290	mark	if,was
R2167	T3290	T3277	advcl	was,is
R2168	T3291	T3292	det	the,sequence
R2169	T3292	T3290	nsubj	sequence,was
R2170	T3293	T3294	det	a,member
R2171	T3294	T3290	attr	member,was
R2172	T3295	T3294	amod	distinct,member
R2173	T3296	T3294	compound	TACC,member
R2174	T3297	T3294	compound	family,member
R2175	T3298	T3277	punct	.,is
R2176	T3413	T3412	prep	of,Placement
R2177	T3414	T3415	det	the,gene
R2178	T3415	T3413	pobj	gene,of
R2179	T3416	T3415	compound	RHAMM,gene
R2180	T3417	T3412	prep	in,Placement
R2181	T3418	T3419	det	the,phylogeny
R2182	T3419	T3417	pobj	phylogeny,in
R2183	T3420	T3419	prep	of,phylogeny
R2184	T3421	T3422	det	the,family
R2185	T3422	T3420	pobj	family,of
R2186	T3423	T3424	amod	coiled,coil
R2187	T3424	T3422	compound	coil,family
R2188	T3425	T3422	compound	gene,family
R2189	T3427	T3428	amod	Human,RHAMM
R2190	T3428	T3429	nsubjpass	RHAMM,proposed
R2191	T3430	T3429	aux	has,proposed
R2192	T3431	T3429	advmod	also,proposed
R2193	T3432	T3429	auxpass	been,proposed
R2194	T3433	T3434	aux	to,be
R2195	T3434	T3429	xcomp	be,proposed
R2196	T3435	T3436	det	the,member
R2197	T3436	T3434	attr	member,be
R2198	T3437	T3436	amod	missing,member
R2199	T3438	T3436	amod	fourth,member
R2200	T3439	T3436	prep	of,member
R2201	T3440	T3441	det	the,family
R2202	T3441	T3439	pobj	family,of
R2203	T3442	T3441	compound	TACC,family
R2204	T3443	T3444	punct	[,10
R2205	T3444	T3429	parataxis	10,proposed
R2206	T3445	T3444	punct	],10
R2207	T3446	T3429	punct	.,proposed
R2208	T3448	T3449	nsubj	Evidence,included
R2209	T3450	T3448	acl	used,Evidence
R2210	T3451	T3450	prep	in,used
R2211	T3452	T3451	pobj	support,in
R2212	T3453	T3452	prep	of,support
R2213	T3454	T3455	det	this,claim
R2214	T3455	T3453	pobj	claim,of
R2215	T3456	T3457	poss	its,location
R2216	T3457	T3449	dobj	location,included
R2217	T3458	T3457	amod	chromosomal,location
R2218	T3459	T3457	prep	on,location
R2219	T3460	T3459	pobj	5q32,on
R2220	T3461	T3457	prep	in,location
R2221	T3462	T3461	pobj	humans,in
R2222	T3463	T3464	punct	(,discussed
R2223	T3464	T3457	parataxis	discussed,location
R2224	T3465	T3464	advmod	below,discussed
R2225	T3466	T3464	punct	),discussed
R2226	T3467	T3457	punct	", ",location
R2227	T3468	T3469	poss	its,similarity
R2228	T3469	T3457	conj	similarity,location
R2229	T3470	T3469	compound	sequence,similarity
R2230	T3471	T3469	prep	in,similarity
R2231	T3472	T3473	poss	its,domain
R2232	T3473	T3471	pobj	domain,in
R2233	T3474	T3475	amod	coiled,coil
R2234	T3475	T3473	compound	coil,domain
R2235	T3476	T3469	prep	to,similarity
R2236	T3477	T3478	det	the,domain
R2237	T3478	T3476	pobj	domain,to
R2238	T3479	T3478	compound	TACC,domain
R2239	T3480	T3469	cc	and,similarity
R2240	T3481	T3482	det	the,localization
R2241	T3482	T3469	conj	localization,similarity
R2242	T3483	T3482	amod	subcellular,localization
R2243	T3484	T3482	prep	of,localization
R2244	T3485	T3486	det	the,protein
R2245	T3486	T3484	pobj	protein,of
R2246	T3487	T3486	compound	RHAMM,protein
R2247	T3488	T3482	prep	in,localization
R2248	T3489	T3490	det	the,centrosome
R2249	T3490	T3488	pobj	centrosome,in
R2250	T3491	T3449	punct	.,included
R2251	T3493	T3494	advmod	However,predict
R2252	T3495	T3494	punct	", ",predict
R2253	T3496	T3497	mark	if,were
R2254	T3497	T3494	advcl	were,predict
R2255	T3498	T3497	nsubj	RHAMM,were
R2256	T3499	T3500	det	a,member
R2257	T3500	T3497	attr	member,were
R2258	T3501	T3502	advmod	bona,fide
R2259	T3502	T3500	amod	fide,member
R2260	T3503	T3500	compound	TACC,member
R2261	T3504	T3500	compound	family,member
R2262	T3505	T3494	punct	", ",predict
R2263	T3506	T3494	advmod	then,predict
R2264	T3507	T3494	nsubj	we,predict
R2265	T3508	T3494	aux	would,predict
R2266	T3509	T3510	poss	its,evolution
R2267	T3510	T3511	nsubj	evolution,be
R2268	T3511	T3494	advcl	be,predict
R2269	T3512	T3511	aux	would,be
R2270	T3513	T3511	acomp	similar,be
R2271	T3514	T3513	prep	to,similar
R2272	T3515	T3514	pobj	those,to
R2273	T3516	T3515	prep	of,those
R2274	T3517	T3518	amod	other,members
R2275	T3518	T3516	pobj	members,of
R2276	T3519	T3518	compound	TACC,members
R2277	T3520	T3518	compound	family,members
R2278	T3521	T3511	punct	", ",be
R2279	T3522	T3511	cc	and,be
R2280	T3523	T3511	conj	fit,be
R2281	T3524	T3523	prep	with,fit
R2282	T3525	T3526	det	the,evolution
R2283	T3526	T3524	pobj	evolution,with
R2284	T3527	T3526	amod	proposed,evolution
R2285	T3528	T3526	prep	of,evolution
R2286	T3529	T3530	det	the,genome
R2287	T3530	T3528	pobj	genome,of
R2288	T3531	T3530	compound	vertebrate,genome
R2289	T3532	T3494	punct	.,predict
R2290	T3534	T3535	advmod	Thus,set
R2291	T3536	T3535	punct	", ",set
R2292	T3537	T3535	nsubj	we,set
R2293	T3538	T3535	prt	out,set
R2294	T3539	T3540	aux	to,identify
R2295	T3540	T3535	advcl	identify,set
R2296	T3541	T3542	compound	RHAMM,orthologues
R2297	T3542	T3540	dobj	orthologues,identify
R2298	T3543	T3542	cc	and,orthologues
R2299	T3544	T3545	amod	related,genes
R2300	T3545	T3542	conj	genes,orthologues
R2301	T3546	T3540	prep	in,identify
R2302	T3547	T3546	pobj	metazoans,in
R2303	T3548	T3540	punct	", ",identify
R2304	T3549	T3550	mark	so,generated
R2305	T3550	T3540	advcl	generated,identify
R2306	T3551	T3550	mark	that,generated
R2307	T3552	T3553	det	a,phylogeny
R2308	T3553	T3550	nsubjpass	phylogeny,generated
R2309	T3554	T3555	advmod	more,complete
R2310	T3555	T3553	amod	complete,phylogeny
R2311	T3556	T3553	prep	of,phylogeny
R2312	T3557	T3558	det	the,family
R2313	T3558	T3556	pobj	family,of
R2314	T3559	T3560	amod	coiled,coil
R2315	T3560	T3558	nmod	coil,family
R2316	T3561	T3558	amod	super,family
R2317	T3562	T3550	aux	could,generated
R2318	T3563	T3550	auxpass	be,generated
R2319	T3564	T3535	punct	.,set
R2320	T3566	T3567	nsubj	We,identified
R2321	T3568	T3569	det	a,gene
R2322	T3569	T3567	dobj	gene,identified
R2323	T3570	T3569	amod	single,gene
R2324	T3571	T3569	compound	RHAMM,gene
R2325	T3572	T3567	prep	in,identified
R2326	T3573	T3574	det	all,deuterostomes
R2327	T3574	T3572	pobj	deuterostomes,in
R2328	T3575	T3576	prep	for,was
R2329	T3576	T3574	relcl	was,deuterostomes
R2330	T3577	T3575	pobj	which,for
R2331	T3578	T3579	nmod	cDNA,sequence
R2332	T3579	T3576	nsubj	sequence,was
R2333	T3580	T3578	cc	and,cDNA
R2334	T3581	T3580	punct	/,and
R2335	T3582	T3580	cc	or,and
R2336	T3583	T3578	conj	genomic,cDNA
R2337	T3584	T3576	acomp	available,was
R2338	T3585	T3576	punct	", ",was
R2339	T3586	T3576	prep	including,was
R2340	T3587	T3588	compound	C.,intestinalis
R2341	T3588	T3586	pobj	intestinalis,including
R2342	T3589	T3567	punct	.,identified
R2343	T3591	T3592	det	No,gene
R2344	T3592	T3594	nsubjpass	gene,identified
R2345	T3593	T3592	compound	RHAMM,gene
R2346	T3595	T3594	auxpass	was,identified
R2347	T3596	T3594	prep	in,identified
R2348	T3597	T3596	pobj	insects,in
R2349	T3598	T3597	cc	or,insects
R2350	T3599	T3597	conj	nematodes,insects
R2351	T3600	T3594	punct	.,identified
R2352	T3602	T3603	nsubj	This,indicates
R2353	T3604	T3605	mark	that,diverged
R2354	T3605	T3603	ccomp	diverged,indicates
R2355	T3606	T3607	det	the,genes
R2356	T3607	T3605	nsubj	genes,diverged
R2357	T3608	T3609	compound	RHAMM,TACC
R2358	T3609	T3607	compound	TACC,genes
R2359	T3610	T3609	punct	/,TACC
R2360	T3611	T3612	mark	after,split
R2361	T3612	T3605	advcl	split,diverged
R2362	T3613	T3614	det	the,deuterostome
R2363	T3614	T3612	nsubj	deuterostome,split
R2364	T3615	T3614	compound	protostome,deuterostome
R2365	T3616	T3614	punct	/,deuterostome
R2366	T3617	T3618	quantmod	833,933
R2367	T3618	T3620	npadvmod	933,MYA
R2368	T3619	T3618	punct	–,933
R2369	T3620	T3612	advmod	MYA,split
R2370	T3621	T3620	punct	", ",MYA
R2371	T3622	T3620	cc	but,MYA
R2372	T3623	T3620	conj	prior,MYA
R2373	T3624	T3623	prep	to,prior
R2374	T3625	T3626	det	the,divergence
R2375	T3626	T3624	pobj	divergence,to
R2376	T3627	T3628	compound	echinodermata,urochordate
R2377	T3628	T3626	compound	urochordate,divergence
R2378	T3629	T3628	punct	/,urochordate
R2379	T3630	T3631	punct	(,MYA
R2380	T3631	T3626	parataxis	MYA,divergence
R2381	T3632	T3633	punct	>,750
R2382	T3633	T3631	npadvmod	750,MYA
R2383	T3634	T3631	punct	),MYA
R2384	T3635	T3603	punct	.,indicates
R2385	T3637	T3638	advmod	Significantly,shows
R2386	T3639	T3638	punct	", ",shows
R2387	T3640	T3641	nmod	sequence,analysis
R2388	T3641	T3638	nsubj	analysis,shows
R2389	T3642	T3640	cc	and,sequence
R2390	T3643	T3640	conj	phylogenetic,sequence
R2391	T3644	T3641	prep	of,analysis
R2392	T3645	T3646	amod	coiled,coil
R2393	T3646	T3647	compound	coil,proteins
R2394	T3647	T3644	pobj	proteins,of
R2395	T3648	T3649	punct	(,Fig.
R2396	T3649	T3641	parataxis	Fig.,analysis
R2397	T3650	T3649	nummod	1,Fig.
R2398	T3651	T3649	punct	),Fig.
R2399	T3652	T3638	advmod	clearly,shows
R2400	T3653	T3654	mark	that,contain
R2401	T3654	T3638	ccomp	contain,shows
R2402	T3655	T3654	nsubj	RHAMM,contain
R2403	T3656	T3654	aux	does,contain
R2404	T3657	T3654	neg	not,contain
R2405	T3658	T3659	det	a,domain
R2406	T3659	T3654	dobj	domain,contain
R2407	T3660	T3659	compound	TACC,domain
R2408	T3661	T3654	cc	and,contain
R2409	T3662	T3663	advmod	instead,forms
R2410	T3663	T3654	conj	forms,contain
R2411	T3664	T3665	det	a,family
R2412	T3665	T3663	dobj	family,forms
R2413	T3666	T3665	amod	distinct,family
R2414	T3667	T3665	prep	of,family
R2415	T3668	T3667	pobj	proteins,of
R2416	T3669	T3663	prep	in,forms
R2417	T3670	T3671	det	the,superfamily
R2418	T3671	T3669	pobj	superfamily,in
R2419	T3672	T3673	amod	coiled,coil
R2420	T3673	T3671	compound	coil,superfamily
R2421	T3674	T3654	punct	", ",contain
R2422	T3675	T3654	cc	and,contain
R2423	T3676	T3654	conj	is,contain
R2424	T3677	T3676	neg	not,is
R2425	T3678	T3679	det	a,descendant
R2426	T3679	T3676	attr	descendant,is
R2427	T3680	T3679	amod	direct,descendant
R2428	T3681	T3679	prep	of,descendant
R2429	T3682	T3683	det	the,gene
R2430	T3683	T3681	pobj	gene,of
R2431	T3684	T3683	amod	ancestral,gene
R2432	T3685	T3683	compound	TACC,gene
R2433	T3686	T3638	punct	.,shows
R2443	T4146	T4145	prep	of,Evolution
R2444	T4147	T4148	det	the,segments
R2445	T4148	T4146	pobj	segments,of
R2446	T4149	T4148	amod	chromosomal,segments
R2447	T4150	T4148	acl	containing,segments
R2448	T4151	T4152	det	the,genes
R2449	T4152	T4150	dobj	genes,containing
R2450	T4153	T4152	compound	TACC,genes
R2451	T4155	T4156	det	The,tree
R2452	T4156	T4158	nsubj	tree,resembles
R2453	T4157	T4156	amod	phylogenetic,tree
R2454	T4159	T4156	prep	of,tree
R2455	T4160	T4161	det	the,genes
R2456	T4161	T4159	pobj	genes,of
R2457	T4162	T4161	compound	FGFR,genes
R2458	T4163	T4158	advmod	closely,resembles
R2459	T4164	T4158	dobj	that,resembles
R2460	T4165	T4164	prep	of,that
R2461	T4166	T4167	det	the,genes
R2462	T4167	T4165	pobj	genes,of
R2463	T4168	T4167	nmod	vertebrate,genes
R2464	T4169	T4167	nmod	TACC1,genes
R2465	T4170	T4169	punct	-,TACC1
R2466	T4171	T4169	nummod	3,TACC1
R2467	T4172	T4158	punct	.,resembles
R2468	T4174	T4175	advmod	Recently,revealed
R2469	T4176	T4175	punct	", ",revealed
R2470	T4177	T4178	amod	detailed,analyses
R2471	T4178	T4175	nsubj	analyses,revealed
R2472	T4179	T4178	prep	of,analyses
R2473	T4180	T4181	det	the,regions
R2474	T4181	T4179	pobj	regions,of
R2475	T4182	T4181	amod	chromosomal,regions
R2476	T4183	T4181	acl	containing,regions
R2477	T4184	T4185	det	the,family
R2478	T4185	T4183	dobj	family,containing
R2479	T4186	T4185	compound	FGFR,family
R2480	T4187	T4185	compound	gene,family
R2481	T4188	T4183	prep	in,containing
R2482	T4189	T4188	pobj	humans,in
R2483	T4190	T4189	punct	", ",humans
R2484	T4191	T4189	conj	mouse,humans
R2485	T4192	T4191	cc	and,mouse
R2486	T4193	T4194	det	the,arthopod
R2487	T4194	T4191	conj	arthopod,mouse
R2488	T4195	T4196	compound	D.,melanogaster
R2489	T4196	T4194	appos	melanogaster,arthopod
R2490	T4197	T4175	aux	have,revealed
R2491	T4198	T4199	det	the,conservation
R2492	T4199	T4175	dobj	conservation,revealed
R2493	T4200	T4199	prep	of,conservation
R2494	T4201	T4202	amod	paralogous,segments
R2495	T4202	T4200	pobj	segments,of
R2496	T4203	T4202	amod	chromosomal,segments
R2497	T4204	T4199	prep	between,conservation
R2498	T4205	T4206	det	these,organisms
R2499	T4206	T4204	pobj	organisms,between
R2500	T4207	T4208	punct	(,Table
R2501	T4208	T4175	parataxis	Table,revealed
R2502	T4209	T4208	dep	Fig.,Table
R2503	T4210	T4209	nummod	2,Fig.
R2504	T4211	T4208	punct	", ",Table
R2505	T4212	T4208	punct	[,Table
R2506	T4213	T4208	dep	13,Table
R2507	T4214	T4208	punct	],Table
R2508	T4215	T4208	punct	", ",Table
R2509	T4216	T4208	nummod	1,Table
R2510	T4217	T4208	punct	[,Table
R2511	T4218	T4208	advcl	see,Table
R2512	T4219	T4220	amod	Additional,file
R2513	T4220	T4218	dobj	file,see
R2514	T4221	T4220	nummod	1,file
R2515	T4222	T4208	punct	],Table
R2516	T4223	T4208	punct	),Table
R2517	T4224	T4175	punct	.,revealed
R2518	T4226	T4227	nsubj	This,provided
R2519	T4228	T4227	aux	has,provided
R2520	T4229	T4230	amod	further,support
R2521	T4230	T4227	dobj	support,provided
R2522	T4231	T4232	mark	that,duplicated
R2523	T4232	T4230	acl	duplicated,support
R2524	T4233	T4234	det	an,segment
R2525	T4234	T4232	nsubjpass	segment,duplicated
R2526	T4235	T4234	amod	ancient,segment
R2527	T4236	T4234	amod	chromosomal,segment
R2528	T4237	T4232	auxpass	was,duplicated
R2529	T4238	T4232	advmod	twice,duplicated
R2530	T4239	T4232	prep	during,duplicated
R2531	T4240	T4241	compound	vertebrate,evolution
R2532	T4241	T4239	pobj	evolution,during
R2533	T4242	T4232	punct	", ",duplicated
R2534	T4243	T4232	prep	with,duplicated
R2535	T4244	T4245	det	the,duplication
R2536	T4245	T4247	nsubj	duplication,occurring
R2537	T4246	T4245	amod	first,duplication
R2538	T4247	T4243	pcomp	occurring,with
R2539	T4248	T4249	dep	that,gave
R2540	T4249	T4245	relcl	gave,duplication
R2541	T4250	T4249	dobj	rise,gave
R2542	T4251	T4249	prep	to,gave
R2543	T4252	T4253	det	the,ancestors
R2544	T4253	T4251	pobj	ancestors,to
R2545	T4254	T4255	amod	human,chromosome
R2546	T4255	T4256	nmod	chromosome,ter
R2547	T4256	T4253	nmod	ter,ancestors
R2548	T4257	T4258	nmod	4p16,5q32
R2549	T4258	T4256	nmod	5q32,ter
R2550	T4259	T4258	punct	/,5q32
R2551	T4260	T4256	punct	-,ter
R2552	T4261	T4256	cc	and,ter
R2553	T4262	T4263	amod	human,chromosome
R2554	T4263	T4264	compound	chromosome,ter
R2555	T4264	T4256	conj	ter,ter
R2556	T4265	T4266	compound	8p,10q23
R2557	T4266	T4264	compound	10q23,ter
R2558	T4267	T4266	punct	/,10q23
R2559	T4268	T4264	punct	-,ter
R2560	T4269	T4247	prep	in,occurring
R2561	T4270	T4271	det	the,stages
R2562	T4271	T4269	pobj	stages,in
R2563	T4272	T4271	amod	early,stages
R2564	T4273	T4271	prep	after,stages
R2565	T4274	T4275	det	the,divergence
R2566	T4275	T4273	pobj	divergence,after
R2567	T4276	T4275	compound	invertebrate,divergence
R2568	T4277	T4227	punct	.,provided
R2569	T4279	T4280	nsubj	This,suggests
R2570	T4281	T4282	mark	that,arose
R2571	T4282	T4280	ccomp	arose,suggests
R2572	T4283	T4284	det	the,pair
R2573	T4284	T4282	nsubj	pair,arose
R2574	T4285	T4284	amod	ancestral,pair
R2575	T4286	T4287	compound	FGFR,TACC
R2576	T4287	T4284	compound	TACC,pair
R2577	T4288	T4287	punct	-,TACC
R2578	T4289	T4284	compound	gene,pair
R2579	T4290	T4291	advmod	most,probably
R2580	T4291	T4282	advmod	probably,arose
R2581	T4292	T4293	amod	prior,to
R2582	T4293	T4282	prep	to,arose
R2583	T4294	T4295	det	the,duplication
R2584	T4295	T4293	pobj	duplication,to
R2585	T4296	T4295	amod	initial,duplication
R2586	T4297	T4295	cc	and,duplication
R2587	T4298	T4299	amod	subsequent,divergence
R2588	T4299	T4295	conj	divergence,duplication
R2589	T4300	T4295	prep	of,duplication
R2590	T4301	T4302	det	these,segments
R2591	T4302	T4300	pobj	segments,of
R2592	T4303	T4302	amod	paralogous,segments
R2593	T4304	T4302	amod	chromosomal,segments
R2594	T4305	T4295	punct	", ",duplication
R2595	T4306	T4295	acl	estimated,duplication
R2596	T4307	T4308	aux	to,occurred
R2597	T4308	T4306	xcomp	occurred,estimated
R2598	T4309	T4308	aux	have,occurred
R2599	T4310	T4311	quantmod	687,155.7
R2600	T4311	T4313	npadvmod	155.7,MYA
R2601	T4312	T4311	punct	±,155.7
R2602	T4313	T4308	advmod	MYA,occurred
R2603	T4314	T4280	punct	.,suggests
R2604	T4316	T4317	nsubj	This,raised
R2605	T4318	T4317	aux	has,raised
R2606	T4319	T4320	det	the,suggestion
R2607	T4320	T4317	dobj	suggestion,raised
R2608	T4321	T4322	mark	that,reside
R2609	T4322	T4320	acl	reside,suggestion
R2610	T4323	T4324	det	a,gene
R2611	T4324	T4322	nsubj	gene,reside
R2612	T4325	T4324	amod	fourth,gene
R2613	T4326	T4324	compound	TACC,gene
R2614	T4327	T4324	prep	in,gene
R2615	T4328	T4327	pobj	vertebrates,in
R2616	T4329	T4322	aux	would,reside
R2617	T4330	T4322	prep	in,reside
R2618	T4331	T4332	det	the,region
R2619	T4332	T4330	pobj	region,in
R2620	T4333	T4332	amod	same,region
R2621	T4334	T4332	amod	chromosomal,region
R2622	T4335	T4332	prep	as,region
R2623	T4336	T4335	pobj	FGFR4,as
R2624	T4337	T4317	punct	.,raised
R2625	T4339	T4340	advmod	Indeed,used
R2626	T4341	T4342	det	this,hypothesis
R2627	T4342	T4340	nsubjpass	hypothesis,used
R2628	T4343	T4340	aux	has,used
R2629	T4344	T4340	auxpass	been,used
R2630	T4345	T4340	prep	in,used
R2631	T4346	T4345	pobj	support,in
R2632	T4347	T4346	prep	for,support
R2633	T4348	T4349	det	the,gene
R2634	T4349	T4347	pobj	gene,for
R2635	T4350	T4349	compound	RHAMM,gene
R2636	T4351	T4349	prep	as,gene
R2637	T4352	T4353	det	a,member
R2638	T4353	T4351	pobj	member,as
R2639	T4354	T4353	prep	of,member
R2640	T4355	T4356	det	the,family
R2641	T4356	T4354	pobj	family,of
R2642	T4357	T4356	compound	TACC,family
R2643	T4358	T4359	punct	[,10
R2644	T4359	T4340	parataxis	10,used
R2645	T4360	T4359	punct	],10
R2646	T4361	T4340	punct	.,used
R2647	T4363	T4364	amod	Human,RHAMM
R2648	T4364	T4365	nsubj	RHAMM,maps
R2649	T4366	T4365	prep	to,maps
R2650	T4367	T4368	compound	chromosome,5q32
R2651	T4368	T4366	pobj	5q32,to
R2652	T4369	T4365	prep	in,maps
R2653	T4370	T4371	det	a,region
R2654	T4371	T4369	pobj	region,in
R2655	T4372	T4371	acl	bounded,region
R2656	T4373	T4372	agent	by,bounded
R2657	T4374	T4373	pobj	GPX3,by
R2658	T4375	T4374	cc	and,GPX3
R2659	T4376	T4374	conj	NKX2E,GPX3
R2660	T4377	T4365	punct	.,maps
R2661	T4379	T4380	det	These,loci
R2662	T4380	T4381	nsubj	loci,separate
R2663	T4382	T4383	nummod	two,clusters
R2664	T4383	T4381	dobj	clusters,separate
R2665	T4384	T4383	prep	of,clusters
R2666	T4385	T4384	pobj	genes,of
R2667	T4386	T4383	prep	on,clusters
R2668	T4387	T4388	amod	human,chromosome
R2669	T4388	T4386	pobj	chromosome,on
R2670	T4389	T4388	nummod	5,chromosome
R2671	T4390	T4391	dep	that,are
R2672	T4391	T4383	relcl	are,clusters
R2713	T4434	T4398	punct	.,located
R2715	T4438	T4446	advcl	provide,attempted
R2716	T4439	T4440	det	the,conservation
R2717	T4440	T4438	nsubj	conservation,provide
R2718	T4441	T4440	prep	of,conservation
R2719	T4442	T4443	compound	gene,order
R2720	T4443	T4441	pobj	order,of
R2721	T4444	T4438	aux	can,provide
R2722	T4445	T4438	advmod	also,provide
R2723	T4447	T4438	dobj	clues,provide
R2724	T4448	T4447	prep	to,clues
R2725	T4449	T4450	det	the,evolution
R2726	T4450	T4448	pobj	evolution,to
R2727	T4451	T4450	prep	of,evolution
R2728	T4452	T4453	compound	gene,regulation
R2729	T4453	T4451	pobj	regulation,of
R2730	T4454	T4446	punct	", ",attempted
R2731	T4455	T4446	nsubj	we,attempted
R2732	T4456	T4446	advmod	next,attempted
R2733	T4457	T4458	aux	to,trace
R2734	T4458	T4446	xcomp	trace,attempted
R2735	T4459	T4460	det	the,evolution
R2736	T4460	T4458	dobj	evolution,trace
R2737	T4461	T4460	prep	of,evolution
R2738	T4462	T4463	det	these,segments
R2739	T4463	T4461	pobj	segments,of
R2740	T4464	T4463	amod	paralogous,segments
R2741	T4465	T4458	prep	by,trace
R2742	T4466	T4465	pcomp	examining,by
R2743	T4467	T4468	det	the,genome
R2744	T4468	T4466	dobj	genome,examining
R2745	T4469	T4468	prep	of,genome
R2746	T4470	T4471	det	the,tunicate
R2747	T4471	T4469	pobj	tunicate,of
R2748	T4472	T4473	compound	C.,intestinalis
R2749	T4473	T4471	appos	intestinalis,tunicate
R2750	T4474	T4475	punct	[,11
R2751	T4475	T4471	parataxis	11,tunicate
R2752	T4476	T4475	punct	],11
R2753	T4477	T4468	cc	and,genome
R2754	T4478	T4479	det	the,genome
R2755	T4479	T4468	conj	genome,genome
R2756	T4480	T4481	amod	most,primitive
R2757	T4481	T4479	amod	primitive,genome
R2758	T4482	T4481	punct	"""",primitive
R2759	T4483	T4481	punct	"""",primitive
R2760	T4484	T4479	amod	compact,genome
R2761	T4485	T4479	compound	vertebrate,genome
R2762	T4486	T4479	acl	sequenced,genome
R2763	T4487	T4486	prep	to,sequenced
R2764	T4488	T4487	pobj	date,to
R2765	T4489	T4479	punct	", ",genome
R2766	T4490	T4491	compound	T.,rubripes
R2767	T4491	T4479	appos	rubripes,genome
R2768	T4492	T4493	punct	[,14
R2769	T4493	T4479	parataxis	14,genome
R2770	T4494	T4493	punct	],14
R2771	T4495	T4446	punct	.,attempted
R2772	T4497	T4498	mark	Although,assembled
R2773	T4498	T4501	advcl	assembled,confirmed
R2774	T4499	T4498	neg	not,assembled
R2775	T4500	T4498	advmod	fully,assembled
R2776	T4502	T4501	punct	", ",confirmed
R2777	T4503	T4501	nsubj	examination,confirmed
R2778	T4504	T4503	prep	of,examination
R2779	T4505	T4506	det	the,genome
R2780	T4506	T4504	pobj	genome,of
R2781	T4507	T4506	prep	of,genome
R2782	T4508	T4509	compound	T.,rubripes
R2783	T4509	T4507	pobj	rubripes,of
R2784	T4510	T4511	det	the,presence
R2785	T4511	T4501	dobj	presence,confirmed
R2786	T4512	T4511	prep	of,presence
R2787	T4513	T4514	amod	chromosomal,segments
R2788	T4514	T4512	pobj	segments,of
R2789	T4515	T4514	amod	paralogous,segments
R2790	T4516	T4515	prep	to,paralogous
R2791	T4517	T4516	pobj	those,to
R2792	T4518	T4517	acl	found,those
R2793	T4519	T4518	prep	in,found
R2794	T4520	T4521	amod	higher,vertebrates
R2795	T4521	T4519	pobj	vertebrates,in
R2796	T4522	T4523	punct	(,Fig.
R2797	T4523	T4501	parataxis	Fig.,confirmed
R2798	T4524	T4523	nummod	2,Fig.
R2799	T4525	T4523	punct	),Fig.
R2800	T4526	T4501	punct	.,confirmed
R2801	T4528	T4529	prep	For,found
R2802	T4530	T4528	pobj	instance,For
R2803	T4531	T4529	punct	", ",found
R2804	T4532	T4533	det	the,orthologues
R2805	T4533	T4529	nsubjpass	orthologues,found
R2806	T4534	T4533	prep	of,orthologues
R2807	T4535	T4534	pobj	GPRK2L,of
R2808	T4536	T4535	cc	and,GPRK2L
R2809	T4537	T4535	conj	RGS12,GPRK2L
R2810	T4538	T4529	auxpass	are,found
R2811	T4539	T4529	prep	on,found
R2812	T4540	T4541	compound	T.,rubripes
R2813	T4541	T4542	compound	rubripes,scaffold
R2814	T4542	T4539	pobj	scaffold,on
R2815	T4543	T4542	nummod	290,scaffold
R2816	T4544	T4542	punct	(,scaffold
R2817	T4545	T4542	appos	emb\|CAAB01000290.1,scaffold
R2818	T4546	T4542	punct	),scaffold
R2819	T4547	T4539	punct	", ",on
R2820	T4548	T4539	cc	and,on
R2821	T4549	T4539	conj	within,on
R2822	T4550	T4551	nummod	300,kb
R2823	T4551	T4549	pobj	kb,within
R2824	T4552	T4551	prep	of,kb
R2825	T4553	T4554	det	each,other
R2826	T4554	T4552	pobj	other,of
R2827	T4555	T4551	prep	in,kb
R2828	T4556	T4557	amod	human,4p16
R2829	T4557	T4555	pobj	4p16,in
R2830	T4558	T4529	punct	.,found
R2831	T4560	T4561	det	The,orthologues
R2832	T4561	T4564	nsubjpass	orthologues,located
R2833	T4562	T4563	compound	T.,rubripes
R2834	T4563	T4561	compound	rubripes,orthologues
R2835	T4565	T4561	prep	of,orthologues
R2836	T4566	T4565	pobj	FGFR3,of
R2837	T4567	T4561	punct	", ",orthologues
R2838	T4568	T4561	appos	LETM1,orthologues
R2839	T4569	T4568	cc	and,LETM1
R2840	T4570	T4568	conj	WHSC1,LETM1
R2841	T4571	T4564	auxpass	are,located
R2842	T4572	T4564	prep	on,located
R2843	T4573	T4574	det	the,scaffold
R2844	T4574	T4572	pobj	scaffold,on
R2845	T4575	T4574	amod	same,scaffold
R2846	T4576	T4577	nummod	166,kb
R2847	T4577	T4574	nmod	kb,scaffold
R2848	T4578	T4574	amod	genomic,scaffold
R2849	T4579	T4574	nummod	251,scaffold
R2850	T4580	T4574	punct	(,scaffold
R2851	T4581	T4574	appos	emb\|CAAB01000166.1,scaffold
R2852	T4582	T4574	punct	),scaffold
R2853	T4583	T4564	punct	.,located
R2854	T4585	T4586	advmod	Significantly,located
R2855	T4587	T4586	punct	", ",located
R2856	T4588	T4589	det	the,orthologues
R2857	T4589	T4586	nsubjpass	orthologues,located
R2858	T4590	T4589	nummod	three,orthologues
R2859	T4591	T4589	amod	human,orthologues
R2860	T4592	T4589	prep	of,orthologues
R2861	T4593	T4594	det	these,genes
R2862	T4594	T4592	pobj	genes,of
R2863	T4595	T4586	auxpass	are,located
R2864	T4596	T4586	advmod	also,located
R2865	T4597	T4586	prep	within,located
R2866	T4598	T4599	nummod	300,kb
R2867	T4599	T4597	pobj	kb,within
R2868	T4600	T4599	prep	of,kb
R2869	T4601	T4602	det	each,other
R2870	T4602	T4600	pobj	other,of
R2871	T4603	T4586	prep	on,located
R2872	T4604	T4603	pobj	4p16,on
R2873	T4605	T4586	punct	.,located
R2874	T4607	T4608	advmod	Furthermore,map
R2875	T4609	T4608	punct	", ",map
R2876	T4610	T4608	nsubj	TACC3,map
R2877	T4611	T4610	cc	and,TACC3
R2878	T4612	T4610	conj	FGFRL,TACC3
R2879	T4613	T4608	prep	to,map
R2880	T4614	T4615	det	the,scaffolds
R2881	T4615	T4613	pobj	scaffolds,to
R2882	T4616	T4615	amod	overlapping,scaffolds
R2883	T4617	T4618	nummod	1184,4669
R2884	T4618	T4615	appos	4669,scaffolds
R2885	T4619	T4618	punct	/,4669
R2886	T4620	T4618	punct	(,4669
R2887	T4621	T4618	appos	emb\|CAAB01004668,4669
R2888	T4622	T4618	punct	),4669
R2889	T4623	T4608	punct	.,map
R2890	T4625	T4626	advmod	Similarly,found
R2891	T4627	T4626	punct	", ",found
R2892	T4628	T4626	nsubjpass	elements,found
R2893	T4629	T4628	prep	of,elements
R2894	T4630	T4631	det	these,clusters
R2895	T4631	T4629	pobj	clusters,of
R2896	T4632	T4631	compound	gene,clusters
R2897	T4633	T4628	punct	", ",elements
R2898	T4634	T4628	acl	extending,elements
R2899	T4635	T4634	prep	from,extending
R2900	T4636	T4635	pobj	HMP19,from
R2901	T4637	T4634	prep	to,extending
R2902	T4638	T4637	pobj	GPRK6,to
R2903	T4639	T4634	prep	in,extending
R2904	T4640	T4641	amod	human,chromosome
R2905	T4641	T4642	compound	chromosome,ter
R2906	T4642	T4639	pobj	ter,in
R2907	T4643	T4642	compound	5q34,ter
R2908	T4644	T4642	punct	-,ter
R2909	T4645	T4626	auxpass	are,found
R2910	T4646	T4626	advmod	also,found
R2911	T4647	T4626	prep	in,found
R2912	T4648	T4649	det	the,pufferfish
R2913	T4649	T4647	pobj	pufferfish,in
R2914	T4650	T4626	punct	", ",found
R2915	T4651	T4626	prep	with,found
R2916	T4652	T4653	det	the,orthologues
R2917	T4653	T4651	pobj	orthologues,with
R2918	T4654	T4655	compound	T.,rubripes
R2919	T4655	T4653	compound	rubripes,orthologues
R2920	T4656	T4653	prep	of,orthologues
R2921	T4657	T4656	pobj	NSD1,of
R2922	T4658	T4653	punct	", ",orthologues
R2923	T4659	T4653	appos	FGFR4,orthologues
R2924	T4660	T4653	cc	and,orthologues
R2925	T4661	T4662	advmod	a,like
R2926	T4662	T4665	amod	like,mapping
R2927	T4663	T4662	npadvmod	RAB,like
R2928	T4664	T4662	punct	-,like
R2929	T4665	T4653	conj	mapping,orthologues
R2930	T4666	T4665	compound	gene,mapping
R2931	T4667	T4653	prep	on,orthologues
R2932	T4668	T4667	pobj	scaffold,on
R2933	T4669	T4668	nummod	407,scaffold
R2934	T4670	T4668	punct	(,scaffold
R2935	T4671	T4668	appos	emb\|CAAB01000407,scaffold
R2936	T4672	T4668	punct	),scaffold
R2937	T4673	T4626	punct	.,found
R2938	T4675	T4676	advmod	However,is
R2939	T4677	T4676	punct	", ",is
R2940	T4678	T4676	expl	there,is
R2941	T4679	T4680	det	no,evidence
R2942	T4680	T4676	attr	evidence,is
R2943	T4681	T4680	prep	for,evidence
R2944	T4682	T4683	det	a,gene
R2945	T4683	T4681	pobj	gene,for
R2946	T4684	T4683	acl	corresponding,gene
R2947	T4685	T4684	prep	to,corresponding
R2948	T4686	T4687	det	a,gene
R2949	T4687	T4685	pobj	gene,to
R2950	T4688	T4687	compound	TACC4,gene
R2951	T4689	T4676	prep	in,is
R2952	T4690	T4689	pobj	any,in
R2953	T4691	T4690	prep	of,any
R2954	T4692	T4693	det	these,clusters
R2955	T4693	T4691	pobj	clusters,of
R2956	T4694	T4676	punct	.,is
R2957	T4696	T4697	mark	As,noted
R2958	T4697	T4698	advcl	noted,indicate
R2959	T4699	T4697	advmod	above,noted
R2960	T4700	T4698	punct	", ",indicate
R2961	T4701	T4702	amod	phylogenetic,analysis
R2962	T4702	T4698	nsubj	analysis,indicate
R2963	T4703	T4702	prep	of,analysis
R2964	T4704	T4705	det	the,sequences
R2965	T4705	T4703	pobj	sequences,of
R2966	T4706	T4705	compound	TACC,sequences
R2967	T4707	T4708	mark	that,are
R2968	T4708	T4698	ccomp	are,indicate
R2969	T4709	T4708	expl	there,are
R2970	T4710	T4711	nummod	two,genes
R2971	T4711	T4708	attr	genes,are
R2972	T4712	T4713	npadvmod	TACC1,related
R2973	T4713	T4711	amod	related,genes
R2974	T4714	T4708	prep	in,are
R2975	T4715	T4716	det	the,pufferfish
R2976	T4716	T4714	pobj	pufferfish,in
R2977	T4717	T4698	punct	.,indicate
R2978	T4719	T4720	nsubjpass	trTACC1B,located
R2979	T4721	T4720	auxpass	is,located
R2980	T4722	T4720	prep	on,located
R2981	T4723	T4724	det	the,scaffold
R2982	T4724	T4722	pobj	scaffold,on
R2983	T4725	T4726	nummod	180,kb
R2984	T4726	T4724	compound	kb,scaffold
R2985	T4727	T4724	nummod	191,scaffold
R2986	T4728	T4724	punct	(,scaffold
R2987	T4729	T4724	appos	emb\|CAAB01000191.1,scaffold
R2988	T4730	T4724	punct	),scaffold
R2989	T4731	T4724	punct	", ",scaffold
R2990	T4732	T4733	dep	which,contains
R2991	T4733	T4724	relcl	contains,scaffold
R2992	T4734	T4733	advmod	also,contains
R2993	T4735	T4736	det	the,orthologues
R2994	T4736	T4733	dobj	orthologues,contains
R2995	T4737	T4736	prep	of,orthologues
R2996	T4738	T4739	amod	several,genes
R2997	T4739	T4737	pobj	genes,of
R2998	T4740	T4739	acl	located,genes
R2999	T4741	T4740	prep	in,located
R3000	T4742	T4743	amod	human,8p21
R3001	T4743	T4741	pobj	8p21,in
R3002	T4744	T4743	compound	chromosome,8p21
R3003	T4745	T4743	punct	-,8p21
R3004	T4746	T4743	nummod	11,8p21
R3005	T4747	T4720	punct	.,located
R3006	T4749	T4750	advmod	Thus,represents
R3007	T4751	T4750	punct	", ",represents
R3008	T4752	T4753	det	this,scaffold
R3009	T4753	T4750	nsubj	scaffold,represents
R3010	T4754	T4755	det	the,segment
R3011	T4755	T4750	dobj	segment,represents
R3012	T4756	T4757	advmod	more,developed
R3013	T4757	T4755	amod	developed,segment
R3014	T4758	T4757	punct	"""",developed
R3015	T4759	T4757	punct	"""",developed
R3016	T4760	T4755	nmod	TACC1,segment
R3017	T4761	T4755	amod	chromosomal,segment
R3018	T4762	T4763	dep	that,is
R3019	T4763	T4755	relcl	is,segment
R3020	T4764	T4763	acomp	evident,is
R3021	T4765	T4763	prep	in,is
R3022	T4766	T4767	amod	higher,vertebrates
R3023	T4767	T4765	pobj	vertebrates,in
R3024	T4768	T4750	punct	.,represents
R3025	T4770	T4771	prep	On,located
R3026	T4772	T4773	det	the,hand
R3027	T4773	T4770	pobj	hand,On
R3028	T4774	T4773	amod	other,hand
R3029	T4775	T4771	punct	", ",located
R3030	T4776	T4777	det	the,gene
R3031	T4777	T4771	nsubjpass	gene,located
R3032	T4778	T4777	compound	trTACC1A,gene
R3033	T4779	T4771	auxpass	is,located
R3034	T4780	T4771	prep	in,located
R3035	T4781	T4782	det	the,scaffold
R3036	T4782	T4780	pobj	scaffold,in
R3037	T4783	T4784	nummod	396,kb
R3038	T4784	T4782	compound	kb,scaffold
R3039	T4785	T4782	nummod	12,scaffold
R3040	T4786	T4782	punct	(,scaffold
R3041	T4787	T4782	appos	emb\|CAAB010012.1,scaffold
R3042	T4788	T4782	punct	),scaffold
R3043	T4789	T4771	punct	.,located
R3044	T4791	T4792	det	This,scaffold
R3045	T4792	T4793	nsubj	scaffold,contains
R3046	T4794	T4793	advmod	also,contains
R3047	T4795	T4796	det	the,orthologues
R3048	T4796	T4793	dobj	orthologues,contains
R3049	T4797	T4798	compound	T.,rubripes
R3050	T4798	T4796	compound	rubripes,orthologues
R3051	T4799	T4796	prep	of,orthologues
R3052	T4800	T4799	pobj	MSX1,of
R3053	T4801	T4800	punct	", ",MSX1
R3054	T4802	T4800	conj	STX18,MSX1
R3055	T4803	T4802	punct	", ",STX18
R3056	T4804	T4802	conj	D4S234E,STX18
R3057	T4805	T4804	cc	and,D4S234E
R3058	T4806	T4807	det	the,gene
R3059	T4807	T4804	conj	gene,D4S234E
R3060	T4808	T4807	amod	predicted,gene
R3061	T4809	T4807	appos	LOC118711,gene
R3062	T4810	T4793	punct	", ",contains
R3063	T4811	T4793	prep	in,contains
R3064	T4812	T4811	pobj	addition,in
R3065	T4813	T4812	prep	to,addition
R3066	T4814	T4813	pobj	sequences,to
R3067	T4815	T4814	prep	with,sequences
R3068	T4816	T4815	pobj	homology,with
R3069	T4817	T4816	prep	to,homology
R3070	T4818	T4817	pobj	LOXL,to
R3071	T4819	T4818	punct	", ",LOXL
R3072	T4820	T4818	conj	EVC,LOXL
R3073	T4821	T4820	punct	", ",EVC
R3074	T4822	T4820	conj	LOC159291,EVC
R3075	T4823	T4822	punct	", ",LOC159291
R3076	T4824	T4822	cc	and,LOC159291
R3077	T4825	T4826	det	the,family
R3078	T4826	T4822	conj	family,LOC159291
R3079	T4827	T4826	compound	LDB,family
R3080	T4828	T4793	punct	.,contains
R3081	T4830	T4831	advmod	Thus,contains
R3082	T4832	T4831	punct	", ",contains
R3083	T4833	T4831	nsubj	scaffold,contains
R3084	T4834	T4833	nummod	12,scaffold
R3085	T4835	T4831	dobj	genes,contains
R3086	T4836	T4835	acl	found,genes
R3087	T4837	T4836	prep	in,found
R3088	T4838	T4839	det	the,regions
R3089	T4839	T4837	pobj	regions,in
R3090	T4840	T4839	prep	of,regions
R3091	T4841	T4842	amod	human,4
R3092	T4842	T4840	pobj	4,of
R3093	T4843	T4842	nmod	chromosome,4
R3094	T4844	T4842	cc	and,4
R3095	T4845	T4842	conj	10,4
R3096	T4846	T4847	dep	that,contain
R3097	T4847	T4835	relcl	contain,genes
R3098	T4848	T4847	advmod	also,contain
R3099	T4849	T4850	det	the,loci
R3100	T4850	T4847	dobj	loci,contain
R3101	T4851	T4850	prep	for,loci
R3102	T4852	T4851	pobj	TACC3,for
R3103	T4853	T4852	cc	and,TACC3
R3104	T4854	T4852	conj	TACC2,TACC3
R3105	T4855	T4847	punct	", ",contain
R3106	T4856	T4847	advmod	respectively,contain
R3107	T4857	T4831	punct	", ",contains
R3108	T4858	T4831	cc	and,contains
R3109	T4859	T4860	aux	may,resemble
R3110	T4860	T4831	conj	resemble,contains
R3111	T4861	T4860	advmod	therefore,resemble
R3112	T4862	T4863	advmod	more,closely
R3113	T4863	T4860	advmod	closely,resemble
R3114	T4864	T4865	det	the,organization
R3115	T4865	T4860	dobj	organization,resemble
R3116	T4866	T4865	amod	genomic,organization
R3117	T4867	T4865	acl	resulting,organization
R3118	T4868	T4867	prep	from,resulting
R3119	T4869	T4870	det	the,duplication
R3120	T4870	T4868	pobj	duplication,from
R3121	T4871	T4870	amod	initial,duplication
R3122	T4872	T4870	prep	of,duplication
R3123	T4873	T4874	det	the,segment
R3124	T4874	T4872	pobj	segment,of
R3125	T4875	T4874	amod	ancestral,segment
R3126	T4876	T4874	amod	paralogous,segment
R3127	T4877	T4874	amod	chromosomal,segment
R3128	T4878	T4831	punct	.,contains
R3129	T4880	T4881	amod	Conserved,clusters
R3130	T4881	T4883	nsubj	clusters,result
R3131	T4882	T4881	amod	paralogous,clusters
R3132	T4884	T4883	aux	may,result
R3133	T4885	T4883	prep	from,result
R3134	T4886	T4887	det	the,clustering
R3135	T4887	T4885	pobj	clustering,from
R3136	T4888	T4887	amod	initial,clustering
R3137	T4889	T4887	prep	of,clustering
R3138	T4890	T4891	det	the,genes
R3139	T4891	T4889	pobj	genes,of
R3140	T4892	T4887	prep	in,clustering
R3141	T4893	T4894	det	a,contig
R3142	T4894	T4892	pobj	contig,in
R3143	T4895	T4896	advmod	relatively,small
R3144	T4896	T4894	amod	small,contig
R3145	T4897	T4894	amod	ancestral,contig
R3146	T4898	T4894	amod	genomic,contig
R3147	T4899	T4883	punct	.,result
R3148	T4901	T4902	det	Some,evidence
R3149	T4902	T4903	nsubj	evidence,is
R3150	T4904	T4902	prep	for,evidence
R3151	T4905	T4906	det	the,existence
R3152	T4906	T4904	pobj	existence,for
R3153	T4907	T4906	prep	of,existence
R3154	T4908	T4909	punct	"""",protoclusters
R3155	T4909	T4907	pobj	protoclusters,of
R3156	T4910	T4909	punct	"""",protoclusters
R3157	T4911	T4912	dep	that,correspond
R3158	T4912	T4909	relcl	correspond,protoclusters
R3159	T4913	T4912	aux	could,correspond
R3160	T4914	T4912	prep	to,correspond
R3161	T4915	T4916	det	the,segments
R3162	T4916	T4914	pobj	segments,to
R3163	T4917	T4916	amod	paralogous,segments
R3164	T4918	T4916	amod	chromosomal,segments
R3165	T4919	T4916	acl	noted,segments
R3166	T4920	T4919	prep	in,noted
R3167	T4921	T4922	amod	higher,vertebrates
R3168	T4922	T4920	pobj	vertebrates,in
R3169	T4923	T4903	acomp	present,is
R3170	T4924	T4903	prep	in,is
R3171	T4925	T4926	det	the,genome
R3172	T4926	T4924	pobj	genome,in
R3173	T4927	T4926	prep	of,genome
R3174	T4928	T4929	det	the,urochordate
R3175	T4929	T4927	pobj	urochordate,of
R3176	T4930	T4931	compound	C.,intestinalis
R3177	T4931	T4929	appos	intestinalis,urochordate
R3178	T4932	T4933	punct	[,11
R3179	T4933	T4903	parataxis	11,is
R3180	T4934	T4933	punct	],11
R3181	T4935	T4903	punct	.,is
R3182	T4937	T4938	prep	For,cluster
R3183	T4939	T4937	pobj	instance,For
R3184	T4940	T4938	punct	", ",cluster
R3185	T4941	T4942	det	the,orthologues
R3186	T4942	T4938	nsubj	orthologues,cluster
R3187	T4943	T4942	prep	of,orthologues
R3188	T4944	T4943	pobj	FGFR,of
R3189	T4945	T4944	punct	", ",FGFR
R3190	T4946	T4944	cc	and,FGFR
R3191	T4947	T4944	conj	WHSC1,FGFR
R3192	T4948	T4942	punct	", ",orthologues
R3193	T4949	T4950	compound	carboxypeptidase,Z
R3194	T4950	T4942	appos	Z,orthologues
R3195	T4951	T4950	cc	and,Z
R3196	T4952	T4950	conj	FLJ25359,Z
R3197	T4953	T4938	prep	within,cluster
R3198	T4954	T4955	det	an,region
R3199	T4955	T4953	pobj	region,within
R3200	T4956	T4957	nummod	85,kb
R3201	T4957	T4955	compound	kb,region
R3202	T4958	T4955	prep	of,region
R3203	T4959	T4960	det	the,genome
R3204	T4960	T4958	pobj	genome,of
R3205	T4961	T4962	compound	C.,intestinalis
R3206	T4962	T4960	compound	intestinalis,genome
R3207	T4963	T4938	cc	and,cluster
R3208	T4964	T4965	det	the,orthologues
R3209	T4965	T4967	nsubjpass	orthologues,maintained
R3210	T4966	T4965	amod	human,orthologues
R3211	T4967	T4938	conj	maintained,cluster
R3212	T4968	T4967	auxpass	are,maintained
R3213	T4969	T4967	advmod	still,maintained
R3214	T4970	T4967	prep	in,maintained
R3215	T4971	T4972	amod	paralogous,segments
R3216	T4972	T4970	pobj	segments,in
R3217	T4973	T4972	prep	of,segments
R3218	T4974	T4973	pobj	4p16,of
R3219	T4975	T4974	punct	", ",4p16
R3220	T4976	T4974	conj	8p,4p16
R3221	T4977	T4976	cc	and,8p
R3222	T4978	T4976	conj	10q,8p
R3223	T4979	T4980	punct	(,Fig.
R3224	T4980	T4967	parataxis	Fig.,maintained
R3225	T4981	T4980	nummod	3,Fig.
R3226	T4982	T4980	punct	", ",Fig.
R3227	T4983	T4980	punct	[,Fig.
R3228	T4984	T4980	advcl	see,Fig.
R3229	T4985	T4986	amod	Additional,file
R3230	T4986	T4984	dobj	file,see
R3231	T4987	T4986	nummod	1,file
R3232	T4988	T4980	punct	],Fig.
R3233	T4989	T4980	punct	),Fig.
R3234	T4990	T4938	punct	.,cluster
R3235	T4992	T4993	advmod	However,noted
R3236	T4994	T4993	punct	", ",noted
R3237	T4995	T4993	nsubjpass	it,noted
R3238	T4996	T4993	aux	should,noted
R3239	T4997	T4993	auxpass	be,noted
R3240	T4998	T4999	mark	that,locate
R3241	T4999	T4993	ccomp	locate,noted
R3242	T5000	T5001	det	no,clusters
R3243	T5001	T4999	nsubjpass	clusters,locate
R3244	T5002	T5001	prep	of,clusters
R3245	T5003	T5002	pobj	genes,of
R3246	T5004	T5003	prep	from,genes
R3247	T5005	T5006	det	the,segments
R3248	T5006	T5004	pobj	segments,from
R3249	T5007	T5006	nmod	vertebrate,segments
R3250	T5008	T5006	amod	paralogous,segments
R3251	T5009	T4999	auxpass	are,locate
R3252	T5010	T4999	advmod	close,locate
R3253	T5011	T5010	prep	to,close
R3254	T5012	T5013	det	the,genes
R3255	T5013	T5011	pobj	genes,to
R3256	T5014	T5013	nmod	TACC,genes
R3257	T5015	T5014	cc	or,TACC
R3258	T5016	T5014	conj	RHAMM,TACC
R3259	T5017	T5013	prep	of,genes
R3260	T5018	T5019	compound	C.,intestinalis
R3261	T5019	T5017	pobj	intestinalis,of
R3262	T5020	T4999	punct	", ",locate
R3263	T5021	T4999	advcl	indicating,locate
R3264	T5022	T5023	mark	that,formed
R3265	T5023	T5021	ccomp	formed,indicating
R3266	T5024	T5025	det	the,formation
R3267	T5025	T5023	nsubj	formation,formed
R3268	T5026	T5025	prep	of,formation
R3269	T5027	T5028	det	the,segments
R3270	T5028	T5026	pobj	segments,of
R3271	T5029	T5030	advmod	much,larger
R3272	T5030	T5028	amod	larger,segments
R3273	T5031	T5028	amod	paralogous,segments
R3274	T5032	T5028	acl	encompassing,segments
R3275	T5033	T5034	det	the,genes
R3276	T5034	T5032	dobj	genes,encompassing
R3277	T5035	T5036	compound	FGFR,TACC
R3278	T5036	T5034	compound	TACC,genes
R3279	T5037	T5036	punct	-,TACC
R3280	T5038	T5023	advmod	later,formed
R3281	T5039	T5038	prep	in,later
R3282	T5040	T5041	amod	evolutionary,time
R3283	T5041	T5039	pobj	time,in
R3284	T5042	T5023	punct	", ",formed
R3285	T5043	T5023	cc	or,formed
R3286	T5044	T5045	advmod	conversely,been
R3287	T5045	T5023	conj	been,formed
R3288	T5046	T5045	aux	have,been
R3289	T5047	T5045	acomp	subject,been
R3290	T5048	T5047	prep	to,subject
R3291	T5049	T5050	amod	extensive,rearrangement
R3292	T5050	T5048	pobj	rearrangement,to
R3293	T5051	T5045	prep	in,been
R3294	T5052	T5051	pobj	tunicates,in
R3295	T5053	T4993	punct	.,noted
R3296	T5055	T5056	prep	In,provides
R3297	T5057	T5055	pobj	combination,In
R3298	T5058	T5057	prep	with,combination
R3299	T5059	T5060	det	the,examination
R3300	T5060	T5058	pobj	examination,with
R3301	T5061	T5060	prep	of,examination
R3302	T5062	T5063	det	the,genome
R3303	T5063	T5061	pobj	genome,of
R3304	T5064	T5065	compound	T.,rubripes
R3305	T5065	T5063	compound	rubripes,genome
R3306	T5066	T5056	punct	", ",provides
R3307	T5067	T5056	nsubj	this,provides
R3308	T5068	T5056	advmod	also,provides
R3309	T5069	T5070	amod	additional,evidence
R3310	T5070	T5056	dobj	evidence,provides
R3311	T5071	T5072	mark	that,include
R3312	T5072	T5070	advcl	include,evidence
R3313	T5073	T5072	preconj	either,include
R3314	T5074	T5075	det	the,round
R3315	T5075	T5072	nsubj	round,include
R3316	T5076	T5075	amod	second,round
R3317	T5077	T5075	prep	of,round
R3318	T5078	T5077	pobj	duplication,of
R3319	T5079	T5078	prep	of,duplication
R3320	T5080	T5081	det	the,segment
R3321	T5081	T5079	pobj	segment,of
R3322	T5082	T5081	amod	chromosomal,segment
R3323	T5083	T5084	dep	that,contained
R3324	T5084	T5081	relcl	contained,segment
R3325	T5085	T5086	det	the,ancestor
R3326	T5086	T5084	dobj	ancestor,contained
R3327	T5087	T5086	nmod	FGFR3,ancestor
R3328	T5088	T5087	punct	/,FGFR3
R3329	T5089	T5087	nummod	4,FGFR3
R3330	T5090	T5072	aux	did,include
R3331	T5091	T5072	neg	not,include
R3332	T5092	T5093	det	a,gene
R3333	T5093	T5072	dobj	gene,include
R3334	T5094	T5093	compound	TACC,gene
R3335	T5095	T5072	punct	", ",include
R3336	T5096	T5072	cc	or,include
R3337	T5097	T5098	mark	that,lost
R3338	T5098	T5072	conj	lost,include
R3339	T5099	T5100	predet	such,gene
R3340	T5100	T5098	nsubjpass	gene,lost
R3341	T5101	T5100	det	a,gene
R3342	T5102	T5098	auxpass	was,lost
R3343	T5103	T5104	advmod	very,early
R3344	T5104	T5098	advmod	early,lost
R3345	T5105	T5104	prep	in,early
R3346	T5106	T5107	compound	vertebrate,evolution
R3347	T5107	T5105	pobj	evolution,in
R3348	T5108	T5098	punct	", ",lost
R3349	T5109	T5098	advmod	prior,lost
R3350	T5110	T5109	prep	to,prior
R3351	T5111	T5112	det	the,divergence
R3352	T5112	T5110	pobj	divergence,to
R3353	T5113	T5112	prep	of,divergence
R3354	T5114	T5115	det	the,lineages
R3355	T5115	T5113	pobj	lineages,of
R3356	T5116	T5115	compound	Gnanthostome,lineages
R3357	T5117	T5056	punct	.,provides
R3358	T5119	T5120	advmod	However,await
R3359	T5121	T5120	punct	", ",await
R3360	T5122	T5123	det	the,resolution
R3361	T5123	T5120	nsubj	resolution,await
R3362	T5124	T5123	amod	final,resolution
R3398	T5160	T5159	amod	other,genes
R3399	T5161	T5159	amod	corresponding,genes
R3400	T5162	T5152	prep	in,contain
R3401	T5163	T5164	det	this,segment
R3402	T5164	T5162	pobj	segment,in
R3403	T5165	T5164	amod	conserved,segment
R3404	T5166	T5120	punct	.,await
R3405	T5507	T5508	amod	Comparative,structure
R3406	T5509	T5508	amod	genomic,structure
R3407	T5510	T5508	prep	of,structure
R3408	T5511	T5512	det	the,family
R3409	T5512	T5510	pobj	family,of
R3410	T5513	T5512	compound	TACC,family
R3411	T5515	T5516	det	The,sequences
R3412	T5516	T5519	nsubj	sequences,extracted
R3413	T5517	T5516	amod	genomic,sequences
R3414	T5518	T5516	compound	DNA,sequences
R3415	T5520	T5516	acl	corresponding,sequences
R3416	T5521	T5520	prep	to,corresponding
R3417	T5522	T5523	det	the,genes
R3418	T5523	T5521	pobj	genes,to
R3419	T5524	T5523	amod	orthologous,genes
R3420	T5525	T5523	compound	TACC,genes
R3421	T5526	T5523	prep	of,genes
R3422	T5527	T5526	pobj	human,of
R3423	T5528	T5527	punct	", ",human
R3424	T5529	T5527	conj	mouse,human
R3425	T5530	T5529	punct	", ",mouse
R3426	T5531	T5529	conj	rat,mouse
R3427	T5532	T5531	punct	", ",rat
R3428	T5533	T5531	conj	pufferfish,rat
R3429	T5534	T5533	punct	", ",pufferfish
R3430	T5535	T5536	compound	C.,intestinalis
R3431	T5536	T5533	conj	intestinalis,pufferfish
R3432	T5537	T5536	punct	", ",intestinalis
R3433	T5538	T5539	compound	D.,melanogaster
R3434	T5539	T5536	conj	melanogaster,intestinalis
R3435	T5540	T5539	cc	and,melanogaster
R3436	T5541	T5542	compound	C.,elegans
R3437	T5542	T5539	conj	elegans,melanogaster
R3438	T5543	T5519	aux	were,extracted
R3439	T5544	T5519	cc	and,extracted
R3440	T5545	T5519	conj	analyzed,extracted
R3441	T5546	T5545	prep	by,analyzed
R3442	T5547	T5546	pobj	Genescan,by
R3443	T5548	T5547	cc	and,Genescan
R3444	T5549	T5547	conj	BLAST,Genescan
R3445	T5550	T5551	aux	to,determine
R3446	T5551	T5519	advcl	determine,extracted
R3447	T5552	T5553	det	the,structure
R3448	T5553	T5551	dobj	structure,determine
R3449	T5554	T5553	amod	genomic,structure
R3450	T5555	T5553	prep	of,structure
R3451	T5556	T5557	det	each,gene
R3452	T5557	T5555	pobj	gene,of
R3453	T5558	T5557	compound	TACC,gene
R3454	T5559	T5519	punct	.,extracted
R3455	T5561	T5562	prep	In,added
R3456	T5563	T5564	det	some,cases
R3457	T5564	T5561	pobj	cases,In
R3458	T5565	T5562	punct	", ",added
R3459	T5566	T5562	prep	for,added
R3460	T5567	T5566	pobj	rat,for
R3461	T5568	T5567	cc	and,rat
R3462	T5569	T5567	conj	pufferfish,rat
R3463	T5570	T5562	punct	", ",added
R3464	T5571	T5562	nsubjpass	exons,added
R3465	T5572	T5562	auxpass	were,added
R3466	T5573	T5562	cc	or,added
R3467	T5574	T5562	conj	modified,added
R3468	T5575	T5574	prep	based,modified
R3469	T5576	T5575	prep	on,based
R3470	T5577	T5578	det	the,similarity
R3471	T5578	T5576	pobj	similarity,on
R3472	T5579	T5578	amod	best,similarity
R3473	T5580	T5578	prep	of,similarity
R3474	T5581	T5582	amod	translated,peptides
R3475	T5582	T5580	pobj	peptides,of
R3476	T5583	T5578	prep	to,similarity
R3477	T5584	T5585	det	the,proteins
R3478	T5585	T5583	pobj	proteins,to
R3479	T5586	T5585	amod	corresponding,proteins
R3480	T5587	T5585	nmod	mouse,proteins
R3481	T5588	T5587	cc	and,mouse
R3482	T5589	T5587	conj	human,mouse
R3483	T5590	T5562	punct	.,added
R3484	T5592	T5593	prep	For,used
R3485	T5594	T5592	pobj	regions,For
R3486	T5595	T5594	prep	with,regions
R3487	T5596	T5597	amod	low,similarity
R3488	T5597	T5595	pobj	similarity,with
R3489	T5598	T5597	compound	sequence,similarity
R3490	T5599	T5594	prep	in,regions
R3491	T5600	T5601	compound	T.,rubripes
R3492	T5601	T5599	pobj	rubripes,in
R3493	T5602	T5593	punct	", ",used
R3494	T5603	T5604	amod	genomic,sequences
R3495	T5604	T5593	nsubjpass	sequences,used
R3496	T5605	T5604	prep	from,sequences
R3497	T5606	T5607	det	the,pufferfish
R3498	T5607	T5605	pobj	pufferfish,from
R3499	T5608	T5609	amod	fresh,water
R3500	T5609	T5607	compound	water,pufferfish
R3501	T5610	T5607	punct	", ",pufferfish
R3502	T5611	T5612	compound	Tetraodon,nigroviridis
R3503	T5612	T5607	appos	nigroviridis,pufferfish
R3504	T5613	T5593	auxpass	were,used
R3505	T5614	T5593	prep	as,used
R3506	T5615	T5616	amod	additional,means
R3507	T5616	T5614	pobj	means,as
R3508	T5617	T5618	aux	to,verify
R3509	T5618	T5616	advcl	verify,means
R3510	T5619	T5620	det	the,exons
R3511	T5620	T5618	dobj	exons,verify
R3512	T5621	T5620	amod	predicted,exons
R3513	T5622	T5593	punct	.,used
R3514	T5624	T5625	det	The,structure
R3515	T5625	T5627	nsubjpass	structure,depicted
R3516	T5626	T5625	amod	general,structure
R3517	T5628	T5625	prep	of,structure
R3518	T5629	T5630	det	the,genes
R3519	T5630	T5628	pobj	genes,of
R3520	T5631	T5630	compound	TACC,genes
R3521	T5632	T5630	cc	and,genes
R3522	T5633	T5630	conj	proteins,genes
R3523	T5634	T5627	auxpass	is,depicted
R3524	T5635	T5627	prep	in,depicted
R3525	T5636	T5635	pobj	Fig.,in
R3526	T5637	T5636	nummod	4,Fig.
R3527	T5638	T5627	punct	.,depicted
R3528	T5640	T5641	det	The,feature
R3529	T5641	T5644	nsubjpass	feature,located
R3530	T5642	T5641	amod	main,feature
R3531	T5643	T5641	amod	conserved,feature
R3532	T5645	T5641	prep	of,feature
R3533	T5646	T5647	det	the,family
R3534	T5647	T5645	pobj	family,of
R3535	T5648	T5647	compound	TACC,family
R3536	T5649	T5641	punct	", ",feature
R3537	T5650	T5651	det	the,domain
R3538	T5651	T5641	appos	domain,feature
R3539	T5652	T5651	compound	TACC,domain
R3540	T5653	T5644	punct	", ",located
R3541	T5654	T5644	auxpass	is,located
R3542	T5655	T5644	prep	at,located
R3543	T5656	T5657	det	the,terminus
R3544	T5657	T5655	pobj	terminus,at
R3545	T5658	T5657	compound	carboxy,terminus
R3546	T5659	T5657	prep	of,terminus
R3547	T5660	T5661	det	the,protein
R3548	T5661	T5659	pobj	protein,of
R3549	T5662	T5644	punct	.,located
R3550	T5664	T5665	prep	In,comprises
R3551	T5666	T5667	det	the,case
R3552	T5667	T5664	pobj	case,In
R3553	T5668	T5667	prep	of,case
R3554	T5669	T5670	det	the,protein
R3555	T5670	T5668	pobj	protein,of
R3556	T5671	T5672	compound	C.,elegans
R3557	T5672	T5670	compound	elegans,protein
R3558	T5673	T5670	compound	TAC,protein
R3559	T5674	T5665	punct	", ",comprises
R3560	T5675	T5676	det	this,structure
R3561	T5676	T5665	nsubj	structure,comprises
R3562	T5677	T5678	det	the,majority
R3563	T5678	T5665	dobj	majority,comprises
R3564	T5679	T5678	prep	of,majority
R3565	T5680	T5681	det	the,protein
R3566	T5681	T5679	pobj	protein,of
R3567	T5682	T5665	cc	and,comprises
R3568	T5683	T5684	auxpass	is,encoded
R3569	T5684	T5665	conj	encoded,comprises
R3570	T5685	T5684	agent	by,encoded
R3571	T5686	T5685	pobj	two,by
R3572	T5687	T5686	prep	of,two
R3573	T5688	T5689	det	the,exons
R3574	T5689	T5687	pobj	exons,of
R3575	T5690	T5689	nummod	three,exons
R3576	T5691	T5689	prep	of,exons
R3577	T5692	T5693	det	the,gene
R3578	T5693	T5691	pobj	gene,of
R3579	T5694	T5665	punct	.,comprises
R3580	T5696	T5697	prep	In,encoded
R3581	T5698	T5699	det	the,organisms
R3582	T5699	T5696	pobj	organisms,In
R3583	T5700	T5699	amod	higher,organisms
R3584	T5701	T5699	punct	", ",organisms
R3585	T5702	T5703	compound	D.,melanogaster
R3586	T5703	T5699	appos	melanogaster,organisms
R3587	T5704	T5703	punct	", ",melanogaster
R3588	T5705	T5703	cc	and,melanogaster
R3589	T5706	T5707	det	the,intestinalis
R3590	T5707	T5703	conj	intestinalis,melanogaster
R3591	T5708	T5709	compound	deuterostomes,C.
R3592	T5709	T5707	compound	C.,intestinalis
R3593	T5710	T5707	prep	to,intestinalis
R3594	T5711	T5710	pobj	human,to
R3595	T5712	T5697	punct	", ",encoded
R3596	T5713	T5714	det	this,feature
R3597	T5714	T5697	nsubjpass	feature,encoded
R3598	T5715	T5697	auxpass	is,encoded
R3599	T5716	T5697	advmod	also,encoded
R3600	T5717	T5697	agent	by,encoded
R3601	T5718	T5719	det	the,exons
R3602	T5719	T5717	pobj	exons,by
R3603	T5720	T5719	amod	final,exons
R3604	T5721	T5719	prep	of,exons
R3605	T5722	T5723	det	the,gene
R3606	T5723	T5721	pobj	gene,of
R3607	T5724	T5725	punct	(,five
R3608	T5725	T5697	parataxis	five,encoded
R3609	T5726	T5725	prep	in,five
R3610	T5727	T5728	compound	D.,melanogaster
R3611	T5728	T5726	pobj	melanogaster,in
R3612	T5729	T5725	punct	", ",five
R3613	T5730	T5725	appos	seven,five
R3614	T5731	T5730	prep	in,seven
R3615	T5732	T5733	det	the,genes
R3616	T5733	T5731	pobj	genes,in
R3617	T5734	T5733	compound	deuterostome,genes
R3618	T5735	T5725	punct	),five
R3619	T5736	T5697	punct	.,encoded
R3620	T5738	T5739	prep	Outside,show
R3621	T5740	T5738	prep	of,Outside
R3622	T5741	T5742	det	the,domain
R3623	T5742	T5740	pobj	domain,of
R3624	T5743	T5742	compound	TACC,domain
R3625	T5744	T5739	punct	", ",show
R3626	T5745	T5739	advmod	however,show
R3627	T5746	T5739	punct	", ",show
R3628	T5747	T5748	compound	TACC,members
R3629	T5748	T5739	nsubj	members,show
R3630	T5749	T5748	compound	family,members
R3631	T5750	T5751	advmod	relatively,little
R3632	T5751	T5752	amod	little,homology
R3633	T5752	T5739	dobj	homology,show
R3634	T5753	T5739	punct	.,show
R3635	T5755	T5756	nsubj	It,is
R3636	T5757	T5756	acomp	interesting,is
R3637	T5758	T5759	mark	that,contains
R3638	T5759	T5756	ccomp	contains,is
R3639	T5760	T5761	det	each,gene
R3640	T5761	T5759	nsubj	gene,contains
R3641	T5762	T5761	compound	TACC,gene
R3642	T5763	T5764	nummod	one,exon
R3643	T5764	T5759	dobj	exon,contains
R3644	T5765	T5764	amod	large,exon
R3645	T5766	T5764	punct	", ",exon
R3646	T5767	T5768	dep	which,shows
R3647	T5768	T5764	relcl	shows,exon
R3648	T5769	T5770	amod	considerable,variability
R3649	T5770	T5768	dobj	variability,shows
R3650	T5771	T5768	prep	between,shows
R3651	T5772	T5773	compound	TACC,orthologues
R3652	T5773	T5771	pobj	orthologues,between
R3653	T5774	T5768	punct	", ",shows
R3654	T5775	T5768	cc	and,shows
R3655	T5776	T5768	conj	constitutes,shows
R3656	T5777	T5778	det	the,difference
R3657	T5778	T5776	dobj	difference,constitutes
R3658	T5779	T5778	amod	main,difference
R3659	T5780	T5778	prep	between,difference
R3660	T5781	T5782	det	the,genes
R3661	T5782	T5780	pobj	genes,between
R3662	T5783	T5782	compound	TACC3,genes
R3663	T5784	T5776	prep	in,constitutes
R3664	T5785	T5786	det	the,vertebrates
R3665	T5786	T5784	pobj	vertebrates,in
R3666	T5787	T5788	punct	(,see
R3667	T5788	T5759	parataxis	see,contains
R3668	T5789	T5788	advmod	below,see
R3669	T5790	T5788	punct	),see
R3670	T5791	T5756	punct	.,is
R3671	T5793	T5794	prep	In,contains
R3672	T5795	T5793	pobj	deuterostomes,In
R3673	T5796	T5794	punct	", ",contains
R3674	T5797	T5798	det	this,exon
R3675	T5798	T5794	nsubj	exon,contains
R3676	T5799	T5800	det	the,repeat
R3677	T5800	T5794	dobj	repeat,contains
R3678	T5801	T5800	compound	SDP,repeat
R3679	T5802	T5800	punct	(,repeat
R3680	T5803	T5800	cc	or,repeat
R3681	T5804	T5805	prep	in,repeat
R3682	T5805	T5800	conj	repeat,repeat
R3683	T5806	T5807	det	the,case
R3684	T5807	T5804	pobj	case,in
R3685	T5808	T5807	prep	of,case
R3686	T5809	T5810	det	the,TACC3
R3687	T5810	T5808	pobj	TACC3,of
R3688	T5811	T5810	amod	murine,TACC3
R3689	T5812	T5810	case	's,TACC3
R3690	T5813	T5805	punct	", ",repeat
R3691	T5814	T5805	det	a,repeat
R3692	T5815	T5816	npadvmod	rodent,specific
R3693	T5816	T5805	amod	specific,repeat
R3694	T5817	T5816	punct	-,specific
R3695	T5818	T5819	nummod	24,acid
R3696	T5819	T5805	compound	acid,repeat
R3697	T5820	T5819	compound	amino,acid
R3698	T5821	T5800	punct	),repeat
R3699	T5822	T5800	punct	", ",repeat
R3700	T5823	T5824	dep	which,is
R3701	T5824	T5800	relcl	is,repeat
R3702	T5825	T5824	acomp	responsible,is
R3703	T5826	T5825	prep	for,responsible
R3704	T5827	T5828	det	the,binding
R3705	T5828	T5826	pobj	binding,for
R3706	T5829	T5828	prep	of,binding
R3707	T5830	T5831	det	the,component
R3708	T5831	T5829	pobj	component,of
R3709	T5832	T5833	nmod	SWI,SNF
R3710	T5833	T5831	nmod	SNF,component
R3711	T5834	T5833	punct	/,SNF
R3712	T5835	T5836	compound	chromatin,remodeling
R3713	T5836	T5833	appos	remodeling,SNF
R3714	T5837	T5833	amod	complex,SNF
R3715	T5838	T5831	appos	GAS41,component
R3716	T5839	T5840	punct	[,16
R3717	T5840	T5824	parataxis	16,is
R3718	T5841	T5840	nummod	15,16
R3719	T5842	T5840	punct	",",16
R3720	T5843	T5840	punct	],16
R3721	T5844	T5794	punct	.,contains
R3722	T5846	T5847	prep	Of,show
R3723	T5848	T5849	det	the,proteins
R3724	T5849	T5846	pobj	proteins,Of
R3725	T5850	T5849	compound	vertebrate,proteins
R3726	T5851	T5849	compound	TACC,proteins
R3727	T5852	T5847	punct	", ",show
R3728	T5853	T5854	det	the,orthologues
R3729	T5854	T5847	nsubj	orthologues,show
R3730	T5855	T5854	compound	TACC3,orthologues
R3731	T5856	T5857	det	the,variability
R3732	T5857	T5847	dobj	variability,show
R3733	T5858	T5857	amod	greatest,variability
R3734	T5859	T5857	prep	in,variability
R3735	T5860	T5859	pobj	size,in
R3736	T5861	T5860	cc	and,size
R3737	T5862	T5860	conj	sequence,size
R3738	T5863	T5847	punct	", ",show
R3739	T5864	T5847	advcl	ranging,show
R3740	T5865	T5864	prep	in,ranging
R3741	T5866	T5865	pobj	size,in
R3742	T5867	T5864	prep	from,ranging
R3743	T5868	T5869	nummod	599,acids
R3744	T5869	T5867	pobj	acids,from
R3745	T5870	T5869	compound	amino,acids
R3746	T5871	T5869	prep	for,acids
R3747	T5872	T5873	det	the,protein
R3748	T5873	T5871	pobj	protein,for
R3749	T5874	T5873	compound	rat,protein
R3750	T5875	T5873	compound	TACC3,protein
R3751	T5876	T5867	punct	", ",from
R3752	T5877	T5867	prep	to,from
R3753	T5878	T5879	nummod	942,acids
R3754	T5879	T5877	pobj	acids,to
R3755	T5880	T5879	compound	amino,acids
R3756	T5881	T5879	prep	in,acids
R3757	T5882	T5883	det	the,protein
R3758	T5883	T5881	pobj	protein,in
R3759	T5884	T5883	compound	Danio,protein
R3760	T5885	T5883	compound	rerio,protein
R3761	T5886	T5847	punct	.,show
R3762	T5888	T5889	det	The,reasons
R3763	T5889	T5890	nsubj	reasons,are
R3764	T5891	T5889	prep	for,reasons
R3765	T5892	T5893	det	these,differences
R3766	T5893	T5891	pobj	differences,for
R3767	T5894	T5890	acomp	apparent,are
R3768	T5895	T5890	prep	from,are
R3769	T5896	T5897	det	the,structure
R3770	T5897	T5895	pobj	structure,from
R3771	T5898	T5897	amod	genomic,structure
R3772	T5899	T5897	prep	of,structure
R3773	T5900	T5901	det	the,orthologues
R3774	T5901	T5899	pobj	orthologues,of
R3775	T5902	T5901	compound	TACC3,orthologues
R3776	T5903	T5890	punct	.,are
R3777	T5905	T5906	nsubjpass	TACC3,divided
R3778	T5907	T5906	aux	can,divided
R3779	T5908	T5906	auxpass	be,divided
R3780	T5909	T5906	prep	into,divided
R3781	T5910	T5911	nummod	three,sections
R3782	T5911	T5909	pobj	sections,into
R3783	T5912	T5911	punct	: ,sections
R3784	T5913	T5914	det	a,region
R3785	T5914	T5911	appos	region,sections
R3786	T5915	T5914	amod	conserved,region
R3787	T5916	T5917	npadvmod	N,terminal
R3788	T5917	T5914	amod	terminal,region
R3789	T5918	T5917	punct	-,terminal
R3790	T5919	T5914	punct	(,region
R3791	T5920	T5914	appos	CNTR,region
R3792	T5921	T5914	punct	),region
R3793	T5922	T5914	prep	of,region
R3794	T5923	T5924	nummod	108,acids
R3795	T5924	T5922	pobj	acids,of
R3796	T5925	T5924	compound	amino,acids
R3797	T5926	T5924	punct	", ",acids
R3798	T5927	T5924	acl	encoded,acids
R3799	T5928	T5927	agent	by,encoded
R3800	T5929	T5930	nmod	exons,2
R3801	T5930	T5928	pobj	2,by
R3802	T5931	T5930	cc	and,2
R3803	T5932	T5930	conj	3,2
R3804	T5933	T5927	prep	in,encoded
R3805	T5934	T5935	det	each,gene
R3806	T5935	T5933	pobj	gene,in
R3807	T5936	T5935	compound	vertebrate,gene
R3808	T5937	T5935	compound	TACC3,gene
R3809	T5938	T5914	punct	", ",region
R3810	T5939	T5940	det	the,domain
R3811	T5940	T5914	conj	domain,region
R3812	T5941	T5940	amod	conserved,domain
R3813	T5942	T5940	compound	TACC,domain
R3814	T5943	T5940	acl	distributed,domain
R3815	T5944	T5943	prep	over,distributed
R3816	T5945	T5946	det	the,exons
R3817	T5946	T5944	pobj	exons,over
R3818	T5947	T5946	amod	final,exons
R3819	T5948	T5946	nummod	seven,exons
R3820	T5949	T5940	punct	", ",domain
R3821	T5950	T5940	cc	and,domain
R3822	T5951	T5952	det	a,region
R3823	T5952	T5940	conj	region,domain
R3824	T5953	T5954	advmod	highly,variable
R3825	T5954	T5952	amod	variable,region
R3826	T5955	T5952	amod	central,region
R3827	T5956	T5906	punct	.,divided
R3828	T5958	T5959	det	The,lack
R3829	T5959	T5960	nsubjpass	lack,noted
R3830	T5961	T5959	prep	of,lack
R3831	T5962	T5961	pobj	conservation,of
R3832	T5963	T5962	prep	in,conservation
R3833	T5964	T5965	preconj	both,size
R3834	T5965	T5963	pobj	size,in
R3835	T5966	T5965	cc	and,size
R3836	T5967	T5965	conj	sequence,size
R3837	T5968	T5965	prep	of,size
R3838	T5969	T5970	det	the,portion
R3839	T5970	T5968	pobj	portion,of
R3840	T5971	T5970	amod	central,portion
R3841	T5972	T5970	prep	of,portion
R3842	T5973	T5974	det	the,proteins
R3843	T5974	T5972	pobj	proteins,of
R3844	T5975	T5974	compound	TACC3,proteins
R3845	T5976	T5974	prep	of,proteins
R3846	T5977	T5978	amod	human,mouse
R3847	T5978	T5976	pobj	mouse,of
R3848	T5979	T5978	cc	and,mouse
R3849	T5980	T5960	aux	has,noted
R3850	T5981	T5960	auxpass	been,noted
R3851	T5982	T5960	advmod	previously,noted
R3852	T5983	T5960	punct	", ",noted
R3853	T5984	T5960	cc	and,noted
R3854	T5985	T5960	conj	accounts,noted
R3855	T5986	T5985	prep	for,accounts
R3856	T5987	T5988	det	the,difference
R3857	T5988	T5986	pobj	difference,for
R3858	T5989	T5988	amod	major,difference
R3859	T5990	T5988	prep	between,difference
R3860	T5991	T5992	det	these,orthologues
R3861	T5992	T5990	pobj	orthologues,between
R3862	T5993	T5992	nummod	two,orthologues
R3863	T5994	T5995	punct	[,2
R3864	T5995	T5985	parataxis	2,accounts
R3865	T5996	T5995	punct	],2
R3866	T5997	T5960	punct	.,noted
R3867	T5999	T6000	det	The,majority
R3868	T6000	T6001	nsubjpass	majority,encoded
R3869	T6002	T6000	prep	of,majority
R3870	T6003	T6004	det	this,portion
R3871	T6004	T6002	pobj	portion,of
R3872	T6005	T6004	amod	central,portion
R3873	T6006	T6004	punct	", ",portion
R3874	T6007	T6008	dep	which,contains
R3875	T6008	T6004	relcl	contains,portion
R3876	T6009	T6010	det	the,motifs
R3877	T6010	T6008	dobj	motifs,contains
R3878	T6011	T6010	compound	SDP,motifs
R3879	T6012	T6010	compound	repeat,motifs
R3880	T6013	T6001	punct	", ",encoded
R3881	T6014	T6001	auxpass	is,encoded
R3882	T6015	T6001	agent	by,encoded
R3883	T6016	T6017	nummod	one,exon
R3884	T6017	T6015	pobj	exon,by
R3885	T6018	T6001	prep	in,encoded
R3886	T6019	T6018	pobj	human,in
R3887	T6020	T6019	cc	and,human
R3888	T6021	T6022	det	the,pufferfish
R3889	T6022	T6019	conj	pufferfish,human
R3890	T6023	T6024	punct	(,emb\|CAAB01001184
R3891	T6024	T6001	parataxis	emb\|CAAB01001184,encoded
R3892	T6025	T6024	punct	),emb\|CAAB01001184
R3893	T6026	T6001	punct	.,encoded
R3894	T6028	T6029	prep	In,composed
R3895	T6030	T6028	pobj	rodents,In
R3896	T6031	T6029	punct	", ",composed
R3897	T6032	T6029	advmod	however,composed
R3898	T6033	T6029	punct	", ",composed
R3899	T6034	T6035	det	this,region
R3900	T6035	T6029	nsubjpass	region,composed
R3901	T6036	T6029	auxpass	is,composed
R3902	T6037	T6038	advmod	almost,entirely
R3903	T6038	T6029	advmod	entirely,composed
R3904	T6039	T6029	prep	of,composed
R3905	T6040	T6041	nummod	seven,repeats
R3906	T6041	T6039	pobj	repeats,of
R3907	T6042	T6043	nummod	24,acid
R3908	T6043	T6041	compound	acid,repeats
R3909	T6044	T6043	compound	amino,acid
R3910	T6045	T6041	punct	", ",repeats
R3911	T6046	T6047	dep	which,located
R3912	T6047	T6041	relcl	located,repeats
R3913	T6048	T6047	auxpass	are,located
R3914	T6049	T6047	prep	in,located
R3915	T6050	T6051	det	a,exon
R3916	T6051	T6049	pobj	exon,in
R3917	T6052	T6051	amod	single,exon
R3918	T6053	T6051	prep	of,exon
R3919	T6054	T6055	det	the,genes
R3920	T6055	T6053	pobj	genes,of
R3921	T6056	T6055	nmod	mouse,genes
R3922	T6057	T6056	cc	and,mouse
R3923	T6058	T6056	conj	rat,mouse
R3924	T6059	T6055	compound	TACC3,genes
R3925	T6060	T6029	punct	.,composed
R3926	T6062	T6063	nsubjpass	It,reported
R3927	T6064	T6063	aux	has,reported
R3928	T6065	T6063	auxpass	been,reported
R3929	T6066	T6063	advmod	previously,reported
R3930	T6067	T6068	mark	that,are
R3931	T6068	T6063	ccomp	are,reported
R3932	T6069	T6068	expl	there,are
R3933	T6070	T6071	nummod	four,variants
R3934	T6071	T6068	attr	variants,are
R3935	T6072	T6073	compound	mouse,TACC3
R3936	T6073	T6071	compound	TACC3,variants
R3937	T6074	T6071	compound	splice,variants
R3938	T6075	T6076	dep	that,differ
R3939	T6076	T6071	relcl	differ,variants
R3940	T6077	T6076	prep	in,differ
R3941	T6078	T6079	det	the,number
R3942	T6079	T6077	pobj	number,in
R3943	T6080	T6079	prep	of,number
R3944	T6081	T6082	det	these,repeats
R3945	T6082	T6080	pobj	repeats,of
R3946	T6083	T6084	punct	[,17
R3947	T6084	T6063	parataxis	17,reported
R3948	T6085	T6084	nummod	2,17
R3949	T6086	T6084	punct	",",17
R3950	T6087	T6084	nummod	7,17
R3951	T6088	T6084	punct	",",17
R3952	T6089	T6084	punct	],17
R3953	T6090	T6063	punct	.,reported
R3954	T6092	T6093	mark	As,are
R3955	T6093	T6096	advcl	are,appears
R3956	T6094	T6095	det	these,repeats
R3957	T6095	T6093	nsubj	repeats,are
R3958	T6097	T6093	acomp	present,are
R3959	T6098	T6093	prep	in,are
R3960	T6099	T6100	det	a,exon
R3961	T6100	T6098	pobj	exon,in
R3962	T6101	T6100	amod	single,exon
R3963	T6102	T6096	punct	", ",appears
R3964	T6103	T6096	nsubj	it,appears
R3965	T6104	T6096	oprd	likely,appears
R3966	T6105	T6106	mark	that,be
R3967	T6106	T6096	ccomp	be,appears
R3968	T6107	T6108	det	these,sequences
R3969	T6108	T6106	nsubj	sequences,be
R3970	T6109	T6108	amod	different,sequences
R3971	T6110	T6106	aux	may,be
R3972	T6111	T6112	det	the,result
R3973	T6112	T6106	attr	result,be
R3974	T6113	T6112	prep	of,result
R3975	T6114	T6115	det	the,polymerases
R3976	T6115	T6113	pobj	polymerases,of
R3977	T6116	T6115	compound	DNA,polymerases
R3978	T6117	T6115	acl	used,polymerases
R3979	T6118	T6117	prep	in,used
R3980	T6119	T6120	det	the,synthesis
R3981	T6120	T6118	pobj	synthesis,in
R3982	T6121	T6120	compound	cDNA,synthesis
R3983	T6122	T6115	cc	and,polymerases
R3984	T6123	T6122	punct	/,and
R3985	T6124	T6122	cc	or,and
R3986	T6125	T6126	compound	PCR,reaction
R3987	T6126	T6127	nsubj	reaction,stuttering
R3988	T6127	T6115	conj	stuttering,polymerases
R3989	T6128	T6127	prep	through,stuttering
R3990	T6129	T6130	det	the,motif
R3991	T6130	T6128	pobj	motif,through
R3992	T6131	T6130	compound	repeat,motif
R3993	T6132	T6096	punct	.,appears
R3994	T6134	T6135	det	The,sequence
R3995	T6135	T6137	nsubj	sequence,is
R3996	T6136	T6135	amod	correct,sequence
R3997	T6138	T6135	punct	", ",sequence
R3998	T6139	T6135	acl	reported,sequence
R3999	T6140	T6139	agent	by,reported
R4000	T6141	T6140	pobj	Sadek,by
R4001	T6142	T6143	advmod	et,al
R4002	T6143	T6141	advmod	al,Sadek
R4003	T6144	T6145	punct	[,7
R4004	T6145	T6139	parataxis	7,reported
R4005	T6146	T6145	punct	],7
R4006	T6147	T6137	punct	", ",is
R4007	T6148	T6149	det	the,one
R4008	T6149	T6137	attr	one,is
R4009	T6150	T6149	acl	used,one
R4010	T6151	T6150	prep	throughout,used
R4011	T6152	T6153	det	the,entirety
R4012	T6153	T6151	pobj	entirety,throughout
R4013	T6154	T6153	prep	of,entirety
R4014	T6155	T6156	det	this,manuscript
R4015	T6156	T6154	pobj	manuscript,of
R4016	T6157	T6137	punct	.,is
R4017	T6159	T6160	det	These,repeats
R4018	T6160	T6161	nsubj	repeats,are
R4019	T6162	T6161	neg	not,are
R4020	T6163	T6161	acomp	evident,are
R4021	T6164	T6161	prep	in,are
R4022	T6165	T6166	det	the,protein
R4023	T6166	T6164	pobj	protein,in
R4024	T6167	T6166	compound	rabbit,protein
R4025	T6168	T6166	punct	", ",protein
R4026	T6169	T6166	cc	or,protein
R4027	T6170	T6171	det	any,protein
R4028	T6171	T6166	conj	protein,protein
R4029	T6172	T6171	amod	other,protein
R4030	T6173	T6171	compound	TACC,protein
R4031	T6174	T6161	punct	", ",are
R4032	T6175	T6161	cc	and,are
R4033	T6176	T6177	aux	may,indicate
R4034	T6177	T6161	conj	indicate,are
R4035	T6178	T6179	mark	that,evolved
R4036	T6179	T6177	ccomp	evolved,indicate
R4037	T6180	T6181	det	the,TACC3
R4038	T6181	T6179	nsubj	TACC3,evolved
R4039	T6182	T6181	compound	rodent,TACC3
R4040	T6183	T6179	aux	has,evolved
R4041	T6184	T6185	amod	distinct,functions
R4042	T6185	T6179	dobj	functions,evolved
R4043	T6186	T6177	punct	", ",indicate
R4044	T6187	T6188	mark	as,noted
R4045	T6188	T6177	advcl	noted,indicate
R4046	T6189	T6188	aux	has,noted
R4047	T6190	T6188	advmod	already,noted
R4048	T6191	T6188	auxpass	been,noted
R4049	T6192	T6188	prep	for,noted
R4050	T6193	T6194	det	the,TACC3
R4051	T6194	T6192	pobj	TACC3,for
R4052	T6195	T6194	amod	amphibian,TACC3
R4053	T6196	T6194	compound	Xenopus,TACC3
R4054	T6197	T6194	punct	", ",TACC3
R4055	T6198	T6194	appos	maskin,TACC3
R4056	T6199	T6200	punct	[,8
R4057	T6200	T6188	parataxis	8,noted
R4058	T6201	T6200	punct	],8
R4059	T6202	T6161	punct	.,are
R4064	T6381	T6382	amod	Alternative,splicing
R4065	T6383	T6382	prep	in,splicing
R4066	T6384	T6385	compound	vertebrate,genes
R4067	T6385	T6383	pobj	genes,in
R4068	T6386	T6385	compound	TACC,genes
R4069	T6388	T6389	mark	Whereas,drive
R4070	T6389	T6393	advcl	drive,give
R4071	T6390	T6391	compound	exon,shuffling
R4072	T6391	T6389	nsubj	shuffling,drive
R4073	T6392	T6389	aux	can,drive
R4074	T6394	T6395	det	the,diversification
R4075	T6395	T6389	dobj	diversification,drive
R4076	T6396	T6395	amod	functional,diversification
R4077	T6397	T6395	prep	of,diversification
R4078	T6398	T6399	compound	gene,families
R4079	T6399	T6397	pobj	families,of
R4080	T6400	T6389	prep	over,drive
R4081	T6401	T6402	amod	evolutionary,time
R4082	T6402	T6400	pobj	time,over
R4083	T6403	T6393	punct	", ",give
R4084	T6404	T6405	det	the,splicing
R4085	T6405	T6393	nsubj	splicing,give
R4086	T6406	T6405	amod	temporal,splicing
R4087	T6407	T6406	cc	and,temporal
R4088	T6408	T6407	punct	/,and
R4089	T6409	T6407	cc	or,and
R4090	T6410	T6411	npadvmod	tissue,specific
R4091	T6411	T6406	conj	specific,temporal
R4092	T6412	T6405	amod	alternative,splicing
R4093	T6413	T6405	prep	of,splicing
R4094	T6414	T6415	det	a,gene
R4095	T6415	T6413	pobj	gene,of
R4096	T6416	T6393	aux	can,give
R4097	T6417	T6393	dobj	rise,give
R4098	T6418	T6393	prep	to,give
R4099	T6419	T6420	amod	functional,diversification
R4100	T6420	T6418	pobj	diversification,to
R4101	T6421	T6420	prep	of,diversification
R4102	T6422	T6423	det	a,gene
R4103	T6423	T6421	pobj	gene,of
R4104	T6424	T6423	amod	single,gene
R4105	T6425	T6393	prep	during,give
R4106	T6426	T6427	det	the,development
R4107	T6427	T6425	pobj	development,during
R4108	T6428	T6427	prep	of,development
R4109	T6429	T6430	det	an,organism
R4110	T6430	T6428	pobj	organism,of
R4111	T6431	T6393	punct	.,give
R4112	T6433	T6434	mark	Although,documented
R4113	T6434	T6443	advcl	documented,observed
R4114	T6435	T6436	det	no,splicing
R4115	T6436	T6434	nsubjpass	splicing,documented
R4116	T6437	T6436	amod	alternative,splicing
R4117	T6438	T6436	prep	of,splicing
R4118	T6439	T6438	pobj	TACC3,of
R4119	T6440	T6434	aux	has,documented
R4120	T6441	T6434	auxpass	been,documented
R4121	T6442	T6434	advmod	clearly,documented
R4122	T6444	T6443	punct	", ",observed
R4123	T6445	T6446	preconj	both,temporal
R4124	T6446	T6447	amod	temporal,splicing
R4125	T6447	T6443	nsubjpass	splicing,observed
R4126	T6448	T6446	cc	and,temporal
R4127	T6449	T6450	npadvmod	tissue,specific
R4128	T6450	T6446	conj	specific,temporal
R4129	T6451	T6443	auxpass	is,observed
R4130	T6452	T6443	prep	in,observed
R4131	T6453	T6454	det	the,genes
R4132	T6454	T6452	pobj	genes,in
R4133	T6455	T6454	nmod	TACC1,genes
R4134	T6456	T6455	cc	and,TACC1
R4135	T6457	T6455	conj	TACC2,TACC1
R4136	T6458	T6443	punct	.,observed
R4137	T6460	T6461	prep	In,accounts
R4138	T6462	T6463	det	the,case
R4139	T6463	T6460	pobj	case,In
R4140	T6464	T6463	prep	of,case
R4141	T6465	T6464	pobj	TACC2,of
R4142	T6466	T6461	punct	", ",accounts
R4143	T6467	T6468	det	an,exon
R4144	T6468	T6461	nsubj	exon,accounts
R4145	T6469	T6468	amod	additional,exon
R4146	T6470	T6468	amod	large,exon
R4147	T6471	T6472	punct	(,kb
R4148	T6472	T6470	parataxis	kb,large
R4149	T6473	T6472	nummod	5,kb
R4150	T6474	T6472	punct	),kb
R4151	T6475	T6461	prep	for,accounts
R4152	T6476	T6477	det	the,difference
R4153	T6477	T6475	pobj	difference,for
R4154	T6478	T6477	amod	main,difference
R4155	T6479	T6477	prep	between,difference
R4156	T6480	T6481	det	the,variants
R4157	T6481	T6479	pobj	variants,between
R4158	T6482	T6481	amod	major,variants
R4159	T6483	T6481	compound	splice,variants
R4160	T6484	T6481	prep	of,variants
R4161	T6485	T6486	det	the,genes
R4162	T6486	T6484	pobj	genes,of
R4163	T6487	T6486	compound	vertebrate,genes
R4164	T6488	T6486	compound	TACC2,genes
R4165	T6489	T6490	punct	[,3
R4166	T6490	T6461	parataxis	3,accounts
R4167	T6491	T6490	punct	],3
R4168	T6492	T6461	punct	.,accounts
R4169	T6494	T6495	det	The,splicing
R4170	T6495	T6497	nsubj	splicing,suggests
R4171	T6496	T6495	amod	alternative,splicing
R4172	T6498	T6495	prep	of,splicing
R4173	T6499	T6500	det	this,exon
R4174	T6500	T6498	pobj	exon,of
R4175	T6501	T6502	det	a,difference
R4176	T6502	T6497	dobj	difference,suggests
R4177	T6503	T6502	amod	major,difference
R4178	T6504	T6502	amod	functional,difference
R4179	T6505	T6502	prep	between,difference
R4180	T6506	T6507	det	the,isoforms
R4181	T6507	T6505	pobj	isoforms,between
R4182	T6508	T6507	nummod	two,isoforms
R4183	T6509	T6507	compound	TACC2,isoforms
R4184	T6510	T6507	punct	", ",isoforms
R4185	T6511	T6507	appos	TACC2s,isoforms
R4186	T6512	T6511	cc	and,TACC2s
R4187	T6513	T6511	conj	TACC2l,TACC2s
R4188	T6514	T6515	punct	[,3
R4189	T6515	T6502	parataxis	3,difference
R4190	T6516	T6515	punct	],3
R4191	T6517	T6502	punct	", ",difference
R4192	T6518	T6519	advmod	as,as
R4193	T6519	T6502	cc	as,difference
R4194	T6520	T6519	advmod	well,as
R4195	T6521	T6522	det	a,difference
R4196	T6522	T6502	conj	difference,difference
R4197	T6523	T6522	amod	significant,difference
R4198	T6524	T6522	prep	between,difference
R4199	T6525	T6524	pobj	TACC2,between
R4200	T6526	T6525	cc	and,TACC2
R4201	T6527	T6528	poss	its,relative
R4202	T6528	T6525	conj	relative,TACC2
R4203	T6529	T6528	amod	closest,relative
R4204	T6530	T6531	compound	TACC,family
R4205	T6531	T6528	compound	family,relative
R4206	T6532	T6528	punct	", ",relative
R4207	T6533	T6528	appos	TACC1,relative
R4208	T6534	T6497	punct	.,suggests
R4209	T6536	T6537	advmod	However,is
R4210	T6538	T6537	punct	", ",is
R4211	T6539	T6540	det	the,function
R4212	T6540	T6537	nsubj	function,is
R4213	T6541	T6540	prep	of,function
R4214	T6542	T6543	det	this,region
R4215	T6543	T6541	pobj	region,of
R4216	T6544	T6543	prep	of,region
R4217	T6545	T6546	det	the,isoform
R4218	T6546	T6544	pobj	isoform,of
R4219	T6547	T6546	compound	TACC2l,isoform
R4220	T6548	T6537	advmod	current,is
R4221	T6549	T6537	acomp	unknown,is
R4222	T6550	T6537	punct	.,is
R4223	T6552	T6553	amod	Alternative,splicing
R4224	T6553	T6554	nsubjpass	splicing,noted
R4225	T6555	T6553	punct	", ",splicing
R4226	T6556	T6553	advmod	together,splicing
R4227	T6557	T6556	prep	with,together
R4228	T6558	T6559	amod	differential,usage
R4229	T6559	T6557	pobj	usage,with
R4230	T6560	T6559	compound	promoter,usage
R4231	T6561	T6554	aux	has,noted
R4232	T6562	T6554	advmod	already,noted
R4233	T6563	T6554	auxpass	been,noted
R4234	T6564	T6554	prep	for,noted
R4235	T6565	T6566	det	the,gene
R4236	T6566	T6564	pobj	gene,for
R4237	T6567	T6566	amod	human,gene
R4238	T6568	T6566	compound	TACC1,gene
R4239	T6569	T6570	punct	[,19
R4240	T6570	T6554	parataxis	19,noted
R4241	T6571	T6570	nummod	18,19
R4242	T6572	T6570	punct	",",19
R4243	T6573	T6570	punct	],19
R4244	T6574	T6554	punct	.,noted
R4245	T6576	T6577	prep	In,identified
R4246	T6578	T6576	pobj	addition,In
R4247	T6579	T6577	punct	", ",identified
R4248	T6580	T6581	mark	as,shown
R4249	T6581	T6577	advcl	shown,identified
R4250	T6582	T6581	prep	in,shown
R4251	T6583	T6582	pobj	Fig.,in
R4252	T6584	T6583	nummod	5,Fig.
R4253	T6585	T6577	punct	", ",identified
R4254	T6586	T6577	nsubj	we,identified
R4255	T6587	T6577	aux	have,identified
R4256	T6588	T6589	amod	additional,isoforms
R4257	T6589	T6577	dobj	isoforms,identified
R4258	T6590	T6589	compound	TACC1,isoforms
R4259	T6591	T6592	dep	that,result
R4260	T6592	T6589	relcl	result,isoforms
R4261	T6593	T6592	prep	from,result
R4262	T6594	T6595	amod	alternative,splicing
R4263	T6595	T6593	pobj	splicing,from
R4264	T6596	T6595	prep	of,splicing
R4265	T6597	T6598	nmod	exons,4a
R4266	T6598	T6596	pobj	4a,of
R4267	T6599	T6598	nummod	1b,4a
R4268	T6600	T6598	punct	-,4a
R4269	T6601	T6577	punct	.,identified
R4270	T6603	T6604	det	The,functions
R4271	T6604	T6605	nsubj	functions,are
R4272	T6605	T6610	ccomp	are,include
R4273	T6606	T6604	prep	of,functions
R4274	T6607	T6608	det	these,isoforms
R4275	T6608	T6606	pobj	isoforms,of
R4276	T6609	T6608	amod	different,isoforms
R4277	T6611	T6605	acomp	unknown,are
R4278	T6612	T6610	punct	", ",include
R4279	T6613	T6610	advmod	however,include
R4280	T6614	T6615	det	the,region
R4281	T6615	T6610	nsubj	region,include
R4282	T6616	T6615	acl	deleted,region
R4283	T6617	T6616	prep	from,deleted
R4284	T6618	T6619	det	the,variants
R4285	T6619	T6617	pobj	variants,from
R4286	T6620	T6619	amod	shorter,variants
R4287	T6621	T6610	aux	can,include
R4288	T6622	T6623	det	the,site
R4289	T6623	T6610	dobj	site,include
R4290	T6624	T6623	compound	binding,site
R4291	T6625	T6623	prep	for,site
R4292	T6626	T6625	pobj	LSm7,for
R4293	T6627	T6628	punct	[,20
R4294	T6628	T6623	parataxis	20,site
R4295	T6629	T6628	punct	],20
R4296	T6630	T6631	punct	(,C
R4297	T6631	T6623	parataxis	C,site
R4298	T6632	T6631	compound	variants,C
R4299	T6633	T6631	punct	", ",C
R4300	T6634	T6631	appos	D,C
R4301	T6635	T6631	punct	", ",C
R4302	T6636	T6631	appos	F,C
R4303	T6637	T6638	punct	-,I
R4304	T6638	T6636	prep	I,F
R4305	T6639	T6631	punct	),C
R4306	T6640	T6623	punct	", ",site
R4307	T6641	T6623	cc	and,site
R4308	T6642	T6641	punct	/,and
R4309	T6643	T6641	cc	or,and
R4310	T6644	T6645	det	the,signals
R4311	T6645	T6623	conj	signals,site
R4312	T6646	T6645	amod	nuclear,signals
R4313	T6647	T6645	compound	localization,signals
R4314	T6648	T6645	cc	and,signals
R4315	T6649	T6650	compound	binding,site
R4316	T6650	T6645	conj	site,signals
R4317	T6651	T6650	prep	for,site
R4318	T6652	T6651	pobj	GAS41,for
R4319	T6653	T6654	punct	[,15
R4320	T6654	T6650	parataxis	15,site
R4321	T6655	T6654	punct	],15
R4322	T6656	T6645	cc	and,signals
R4323	T6657	T6645	conj	PCTAIRE2BP,signals
R4324	T6658	T6659	punct	[,20
R4325	T6659	T6657	parataxis	20,PCTAIRE2BP
R4326	T6660	T6659	punct	],20
R4327	T6661	T6662	punct	(,B
R4328	T6662	T6657	parataxis	B,PCTAIRE2BP
R4329	T6663	T6662	compound	isoforms,B
R4330	T6664	T6665	punct	-,D
R4331	T6665	T6662	prep	D,B
R4332	T6666	T6662	punct	", ",B
R4333	T6667	T6662	appos	S,B
R4334	T6668	T6662	punct	),B
R4335	T6669	T6610	punct	.,include
R4336	T6671	T6672	nsubjpass	One,localized
R4337	T6673	T6671	prep	of,One
R4338	T6674	T6675	det	these,isoforms
R4339	T6675	T6673	pobj	isoforms,of
R4340	T6676	T6671	punct	", ",One
R4341	T6677	T6671	appos	TACC1S,One
R4342	T6678	T6672	auxpass	is,localized
R4343	T6679	T6680	advmod	exclusively,to
R4344	T6680	T6672	prep	to,localized
R4345	T6681	T6682	det	the,cytoplasm
R4346	T6682	T6680	pobj	cytoplasm,to
R4347	T6683	T6684	punct	[,19
R4348	T6684	T6672	parataxis	19,localized
R4349	T6685	T6684	punct	],19
R4350	T6686	T6672	punct	", ",localized
R4351	T6687	T6672	advcl	suggesting,localized
R4352	T6688	T6689	mark	that,be
R4353	T6689	T6687	ccomp	be,suggesting
R4354	T6690	T6691	det	the,isoforms
R4355	T6691	T6689	nsubj	isoforms,be
R4356	T6692	T6691	amod	shorter,isoforms
R4357	T6693	T6689	aux	would,be
R4358	T6694	T6689	neg	not,be
R4359	T6695	T6689	acomp	able,be
R4360	T6696	T6697	aux	to,interact
R4361	T6697	T6695	xcomp	interact,able
R4362	T6698	T6697	prep	with,interact
R4363	T6699	T6698	pobj	elements,with
R4364	T6700	T6699	prep	of,elements
R4365	T6701	T6702	det	the,remodeling
R4366	T6702	T6700	pobj	remodeling,of
R4367	T6703	T6702	compound	chomatin,remodeling
R4368	T6704	T6699	cc	and,elements
R4369	T6705	T6704	punct	/,and
R4370	T6706	T6704	cc	or,and
R4371	T6707	T6708	compound	RNA,machinery
R4372	T6708	T6699	conj	machinery,elements
R4373	T6709	T6708	compound	processing,machinery
R4374	T6710	T6697	prep	in,interact
R4375	T6711	T6712	det	the,nucleus
R4376	T6712	T6710	pobj	nucleus,in
R4377	T6713	T6672	punct	.,localized
R4378	T6715	T6716	advmod	Thus,result
R4379	T6717	T6716	punct	", ",result
R4380	T6718	T6716	nsubj	changes,result
R4381	T6719	T6718	prep	in,changes
R4382	T6720	T6721	det	the,complement
R4383	T6721	T6719	pobj	complement,in
R4384	T6722	T6721	prep	of,complement
R4385	T6723	T6724	compound	TACC1,isoforms
R4386	T6724	T6722	pobj	isoforms,of
R4387	T6725	T6718	prep	in,changes
R4388	T6726	T6727	det	the,cell
R4389	T6727	T6725	pobj	cell,in
R4390	T6728	T6716	aux	may,result
R4391	T6729	T6716	prep	in,result
R4392	T6730	T6729	pobj	alterations,in
R4393	T6731	T6730	prep	in,alterations
R4394	T6732	T6733	amod	cellular,metabolism
R4395	T6733	T6731	pobj	metabolism,in
R4396	T6734	T6733	compound	RNA,metabolism
R4397	T6735	T6730	prep	at,alterations
R4398	T6736	T6737	amod	multiple,levels
R4399	T6737	T6735	pobj	levels,at
R4400	T6738	T6716	punct	", ",result
R4401	T6739	T6716	cc	and,result
R4402	T6740	T6741	aux	may,account
R4403	T6741	T6716	conj	account,result
R4404	T6742	T6741	prep	for,account
R4405	T6743	T6744	det	the,observation
R4406	T6744	T6742	pobj	observation,for
R4407	T6745	T6746	mark	that,associated
R4408	T6746	T6744	acl	associated,observation
R4409	T6747	T6748	nmod	TACC1D,isoforms
R4410	T6748	T6746	nsubjpass	isoforms,associated
R4411	T6749	T6747	cc	and,TACC1D
R4412	T6750	T6747	conj	TACC1F,TACC1D
R4413	T6751	T6746	auxpass	are,associated
R4414	T6752	T6746	prep	with,associated
R4415	T6753	T6754	amod	tumorigenic,changes
R4416	T6754	T6752	pobj	changes,with
R4417	T6755	T6746	prep	in,associated
R4418	T6756	T6757	amod	gastric,mucosa
R4419	T6757	T6755	pobj	mucosa,in
R4420	T6758	T6759	punct	[,18
R4421	T6759	T6744	parataxis	18,observation
R4422	T6760	T6759	punct	],18
R4423	T6761	T6716	punct	.,result
R4426	T7167	T7168	advmod	In,silico
R4427	T7168	T7169	amod	silico,modeling
R4428	T7170	T7169	prep	of,modeling
R4429	T7171	T7172	det	the,evolution
R4430	T7172	T7170	pobj	evolution,of
R4431	T7173	T7172	prep	of,evolution
R4432	T7174	T7175	compound	TACC,protein
R4433	T7175	T7176	compound	protein,function
R4434	T7176	T7173	pobj	function,of
R4435	T7178	T7179	det	The,structure
R4436	T7179	T7183	nsubj	structure,suggests
R4437	T7180	T7179	nmod	protein,structure
R4438	T7181	T7180	cc	and,protein
R4439	T7182	T7180	conj	genomic,protein
R4440	T7184	T7179	prep	of,structure
R4441	T7185	T7186	det	the,members
R4442	T7186	T7184	pobj	members,of
R4443	T7187	T7188	amod	present,day
R4444	T7188	T7186	compound	day,members
R4445	T7189	T7190	compound	TACC,family
R4446	T7190	T7186	compound	family,members
R4447	T7191	T7192	mark	that,mediated
R4448	T7192	T7183	ccomp	mediated,suggests
R4449	T7193	T7194	det	the,function
R4450	T7194	T7192	nsubjpass	function,mediated
R4451	T7195	T7194	prep	of,function
R4452	T7196	T7197	det	the,protein
R4453	T7197	T7195	pobj	protein,of
R4454	T7198	T7197	amod	ancestral,protein
R4455	T7199	T7197	compound	TACC,protein
R4456	T7200	T7192	auxpass	was,mediated
R4457	T7201	T7202	advmod	solely,through
R4458	T7202	T7192	prep	through,mediated
R4459	T7203	T7204	det	the,interactions
R4460	T7204	T7202	pobj	interactions,through
R4461	T7205	T7204	prep	of,interactions
R4462	T7206	T7207	det	the,domain
R4463	T7207	T7205	pobj	domain,of
R4464	T7208	T7207	amod	conserved,domain
R4465	T7209	T7207	compound	TACC,domain
R4466	T7210	T7183	punct	.,suggests
R4467	T7212	T7213	advcl	Using,predicted
R4468	T7214	T7215	det	an,model
R4469	T7215	T7212	dobj	model,Using
R4470	T7216	T7217	advmod	in,silico
R4471	T7217	T7215	amod	silico,model
R4472	T7218	T7219	compound	protein,protein
R4473	T7219	T7221	compound	protein,interaction
R4474	T7220	T7219	punct	-,protein
R4475	T7221	T7215	compound	interaction,model
R4476	T7222	T7215	prep	based,model
R4477	T7223	T7222	prep	upon,based
R4478	T7224	T7225	amod	known,components
R4479	T7225	T7223	pobj	components,upon
R4480	T7226	T7227	amod	mitotic,spindle
R4481	T7227	T7225	nmod	spindle,components
R4482	T7228	T7227	cc	and,spindle
R4483	T7229	T7227	conj	centrosomal,spindle
R4484	T7230	T7213	punct	", ",predicted
R4485	T7231	T7213	nsubj	we,predicted
R4486	T7232	T7213	aux	have,predicted
R4487	T7233	T7213	advmod	previously,predicted
R4488	T7234	T7235	det	a,number
R4489	T7235	T7213	dobj	number,predicted
R4490	T7236	T7235	prep	of,number
R4491	T7237	T7238	amod	additional,interactions
R4492	T7238	T7236	pobj	interactions,of
R4493	T7239	T7240	dep	that,conserved
R4494	T7240	T7238	relcl	conserved,interactions
R4495	T7241	T7240	aux	could,conserved
R4496	T7242	T7240	auxpass	be,conserved
R4497	T7243	T7240	prep	between,conserved
R4498	T7244	T7245	det	a,homologue
R4499	T7245	T7243	pobj	homologue,between
R4500	T7246	T7245	amod	functional,homologue
R4501	T7247	T7245	compound	TACC,homologue
R4502	T7248	T7245	prep	in,homologue
R4503	T7249	T7248	pobj	yeast,in
R4504	T7250	T7245	punct	", ",homologue
R4505	T7251	T7245	appos	spc,homologue
R4506	T7252	T7251	punct	-,spc
R4507	T7253	T7251	nummod	72,spc
R4508	T7254	T7245	punct	", ",homologue
R4509	T7255	T7245	cc	and,homologue
R4510	T7256	T7257	nummod	one,proteins
R4511	T7257	T7245	conj	proteins,homologue
R4512	T7258	T7256	cc	or,one
R4513	T7259	T7256	conj	more,one
R4514	T7260	T7257	amod	human,proteins
R4515	T7261	T7257	compound	TACC,proteins
R4516	T7262	T7263	punct	[,21
R4517	T7263	T7213	parataxis	21,predicted
R4518	T7264	T7263	punct	],21
R4519	T7265	T7213	punct	.,predicted
R4520	T7267	T7268	advmod	Thus,known
R4521	T7269	T7268	punct	", ",known
R4522	T7270	T7268	nsubjpass	it,known
R4523	T7271	T7268	auxpass	is,known
R4524	T7272	T7273	mark	that,interact
R4525	T7273	T7268	ccomp	interact,known
R4526	T7274	T7275	predet	all,proteins
R4527	T7275	T7273	nsubj	proteins,interact
R4528	T7276	T7275	det	the,proteins
R4529	T7277	T7275	compound	TACC,proteins
R4530	T7278	T7275	acl	examined,proteins
R4531	T7279	T7278	prep	to,examined
R4532	T7280	T7279	pobj	date,to
R4533	T7281	T7273	punct	", ",interact
R4534	T7282	T7273	prep	via,interact
R4535	T7283	T7284	det	the,domain
R4536	T7284	T7282	pobj	domain,via
R4537	T7285	T7284	compound	TACC,domain
R4538	T7286	T7273	punct	", ",interact
R4539	T7287	T7273	prep	with,interact
R4540	T7288	T7289	det	the,proteins
R4541	T7289	T7287	pobj	proteins,with
R4542	T7290	T7291	npadvmod	microtubule,centrosomal
R4543	T7291	T7289	amod	centrosomal,proteins
R4544	T7292	T7291	punct	/,centrosomal
R4545	T7293	T7289	prep	of,proteins
R4546	T7294	T7295	det	the,family
R4547	T7295	T7293	pobj	family,of
R4548	T7296	T7295	nmod	stu2,family
R4549	T7297	T7296	punct	/,stu2
R4550	T7298	T7296	appos	msps,stu2
R4551	T7299	T7296	punct	/,stu2
R4552	T7300	T7301	compound	ch,TOG
R4553	T7301	T7296	appos	TOG,stu2
R4554	T7302	T7301	punct	-,TOG
R4555	T7303	T7304	punct	[,5
R4556	T7304	T7289	parataxis	5,proteins
R4557	T7305	T7304	punct	",",5
R4558	T7306	T7304	appos	6,5
R4559	T7307	T7304	punct	",",5
R4560	T7308	T7304	appos	22,5
R4561	T7309	T7310	punct	-,24
R4562	T7310	T7308	prep	24,22
R4563	T7311	T7304	punct	],5
R4564	T7312	T7287	punct	", ",with
R4565	T7313	T7287	cc	and,with
R4566	T7314	T7287	conj	with,with
R4567	T7315	T7316	det	the,kinases
R4568	T7316	T7314	pobj	kinases,with
R4569	T7317	T7316	compound	Aurora,kinases
R4570	T7318	T7319	punct	[,25
R4571	T7319	T7316	parataxis	25,kinases
R4572	T7320	T7319	nummod	20,25
R4573	T7321	T7319	punct	",",25
R4574	T7322	T7319	nummod	21,25
R4575	T7323	T7319	punct	",",25
R4576	T7324	T7319	punct	],25
R4577	T7325	T7268	punct	.,known
R4578	T7327	T7328	det	These,interactions
R4579	T7328	T7329	nsubjpass	interactions,required
R4580	T7330	T7329	auxpass	are,required
R4581	T7331	T7329	prep	for,required
R4582	T7332	T7333	det	the,accumulation
R4583	T7333	T7331	pobj	accumulation,for
R4584	T7334	T7333	prep	of,accumulation
R4585	T7335	T7336	det	the,proteins
R4586	T7336	T7334	pobj	proteins,of
R4587	T7337	T7338	nmod	D,TACC
R4588	T7338	T7336	nmod	TACC,proteins
R4589	T7339	T7338	punct	-,TACC
R4590	T7340	T7338	punct	", ",TACC
R4591	T7341	T7338	conj	spc72,TACC
R4592	T7342	T7341	punct	", ",spc72
R4593	T7343	T7341	conj	ceTAC1,spc72
R4594	T7344	T7343	cc	and,ceTAC1
R4595	T7345	T7343	conj	TACC3,ceTAC1
R4596	T7346	T7333	prep	to,accumulation
R4597	T7347	T7348	det	the,centrosome
R4598	T7348	T7346	pobj	centrosome,to
R4599	T7349	T7350	punct	[,5
R4600	T7350	T7329	parataxis	5,required
R4601	T7351	T7350	punct	",",5
R4602	T7352	T7350	appos	6,5
R4603	T7353	T7350	punct	",",5
R4604	T7354	T7350	appos	22,5
R4605	T7355	T7356	punct	-,24
R4606	T7356	T7354	prep	24,22
R4607	T7357	T7350	punct	],5
R4608	T7358	T7329	punct	.,required
R4609	T7360	T7361	advmod	Hence,is
R4610	T7362	T7361	punct	", ",is
R4611	T7363	T7364	det	this,interaction
R4612	T7364	T7361	nsubj	interaction,is
R4613	T7365	T7364	amod	functional,interaction
R4614	T7366	T7364	prep	with,interaction
R4615	T7367	T7368	det	the,centrosome
R4616	T7368	T7366	pobj	centrosome,with
R4617	T7369	T7368	cc	and,centrosome
R4618	T7370	T7371	amod	mitotic,spindle
R4619	T7371	T7368	conj	spindle,centrosome
R4620	T7372	T7361	acomp	likely,is
R4621	T7373	T7374	aux	to,represent
R4622	T7374	T7372	xcomp	represent,likely
R4623	T7375	T7376	det	the,function
R4624	T7376	T7374	dobj	function,represent
R4625	T7377	T7376	amod	ancient,function
R4626	T7378	T7376	punct	", ",function
R4627	T7379	T7376	amod	conserved,function
R4628	T7380	T7376	prep	of,function
R4629	T7381	T7382	det	the,family
R4630	T7382	T7380	pobj	family,of
R4631	T7383	T7382	compound	TACC,family
R4632	T7384	T7361	punct	.,is
R4633	T7386	T7387	advmod	However,is
R4634	T7388	T7387	punct	", ",is
R4635	T7389	T7387	nsubj	it,is
R4636	T7390	T7387	acomp	apparent,is
R4637	T7391	T7392	mark	that,differ
R4638	T7392	T7387	ccomp	differ,is
R4639	T7393	T7394	det	the,proteins
R4640	T7394	T7392	nsubj	proteins,differ
R4641	T7395	T7394	amod	human,proteins
R4642	T7396	T7394	compound	TACC,proteins
R4643	T7397	T7392	advmod	also,differ
R4644	T7398	T7392	prep	in,differ
R4645	T7399	T7400	poss	their,ability
R4646	T7400	T7398	pobj	ability,in
R4647	T7401	T7402	aux	to,interact
R4648	T7402	T7400	acl	interact,ability
R4649	T7403	T7402	prep	with,interact
R4650	T7404	T7405	det	the,kinases
R4651	T7405	T7403	pobj	kinases,with
R4652	T7406	T7405	compound	Aurora,kinases
R4653	T7407	T7387	punct	.,is
R4654	T7409	T7410	prep	For,interact
R4655	T7411	T7409	pobj	instance,For
R4656	T7412	T7410	punct	", ",interact
R4657	T7413	T7410	nsubj	TACC1,interact
R4658	T7414	T7413	cc	and,TACC1
R4659	T7415	T7413	conj	TACC3,TACC1
R4660	T7416	T7410	prep	with,interact
R4661	T7417	T7418	compound	Aurora,A
R4662	T7418	T7419	compound	A,kinase
R4663	T7419	T7416	pobj	kinase,with
R4664	T7420	T7410	punct	", ",interact
R4665	T7421	T7422	mark	whereas,interacts
R4666	T7422	T7410	advcl	interacts,interact
R4667	T7423	T7422	nsubj	TACC2,interacts
R4668	T7424	T7422	prep	with,interacts
R4669	T7425	T7426	compound	Aurora,C
R4670	T7426	T7427	compound	C,kinase
R4671	T7427	T7424	pobj	kinase,with
R4672	T7428	T7429	punct	[,21
R4673	T7429	T7422	parataxis	21,interacts
R4674	T7430	T7429	punct	],21
R4675	T7431	T7410	punct	", ",interact
R4676	T7432	T7410	advcl	suggesting,interact
R4677	T7433	T7434	det	a,degree
R4678	T7434	T7432	dobj	degree,suggesting
R4679	T7435	T7434	prep	of,degree
R4680	T7436	T7437	amod	functional,specialization
R4681	T7437	T7435	pobj	specialization,of
R4682	T7438	T7434	prep	in,degree
R4683	T7439	T7440	det	the,derivatives
R4684	T7440	T7438	pobj	derivatives,in
R4685	T7441	T7440	prep	of,derivatives
R4686	T7442	T7443	det	the,TACC
R4687	T7443	T7441	pobj	TACC,of
R4688	T7444	T7443	amod	ancestral,TACC
R4689	T7445	T7443	compound	chordate,TACC
R4690	T7446	T7434	punct	", ",degree
R4691	T7447	T7434	prep	after,degree
R4692	T7448	T7449	det	the,radiation
R4693	T7449	T7447	pobj	radiation,after
R4694	T7450	T7449	prep	of,radiation
R4695	T7451	T7452	det	the,genes
R4696	T7452	T7450	pobj	genes,of
R4697	T7453	T7452	compound	vertebrate,genes
R4698	T7454	T7452	compound	TACC,genes
R4699	T7455	T7410	punct	.,interact
R4700	T7457	T7458	det	The,localization
R4701	T7458	T7459	nsubj	localization,suggests
R4702	T7460	T7458	prep	of,localization
R4703	T7461	T7462	det	the,proteins
R4704	T7462	T7460	pobj	proteins,of
R4705	T7463	T7462	compound	vertebrate,proteins
R4706	T7464	T7462	compound	TACC,proteins
R4707	T7465	T7458	prep	in,localization
R4708	T7466	T7467	det	the,nucleus
R4709	T7467	T7465	pobj	nucleus,in
R4710	T7468	T7467	compound	interphase,nucleus
R4711	T7469	T7470	punct	[,27
R4712	T7470	T7458	parataxis	27,localization
R4713	T7471	T7470	nummod	15,27
R4714	T7472	T7470	punct	",",27
R4715	T7473	T7470	nummod	26,27
R4716	T7474	T7470	punct	",",27
R4717	T7475	T7470	punct	],27
R4718	T7476	T7477	mark	that,have
R4719	T7477	T7459	ccomp	have,suggests
R4720	T7478	T7477	nsubj	they,have
R4721	T7479	T7480	amod	additional,functions
R4722	T7480	T7477	dobj	functions,have
R4723	T7481	T7480	prep	outside,functions
R4724	T7482	T7483	poss	their,role
R4725	T7483	T7481	pobj	role,outside
R4726	T7484	T7483	amod	ancient,role
R4727	T7485	T7483	prep	in,role
R4728	T7486	T7487	det	the,dynamics
R4729	T7487	T7485	pobj	dynamics,in
R4730	T7488	T7487	nmod	centrosome,dynamics
R4731	T7489	T7488	cc	and,centrosome
R4732	T7490	T7488	conj	microtubule,centrosome
R4733	T7491	T7459	punct	.,suggests
R4734	T7493	T7494	advmod	Thus,seems
R4735	T7495	T7494	punct	", ",seems
R4736	T7496	T7494	nsubj	it,seems
R4737	T7497	T7494	oprd	likely,seems
R4738	T7498	T7499	mark	that,integrated
R4739	T7499	T7494	ccomp	integrated,seems
R4740	T7500	T7501	compound	TACC,members
R4741	T7501	T7499	nsubj	members,integrated
R4742	T7502	T7501	compound	family,members
R4743	T7503	T7501	prep	in,members
R4744	T7504	T7503	pobj	protostomes,in
R4745	T7505	T7504	cc	and,protostomes
R4746	T7506	T7504	conj	deuterostomes,protostomes
R4747	T7507	T7499	aux	have,integrated
R4748	T7508	T7509	amod	new,functions
R4749	T7509	T7499	dobj	functions,integrated
R4750	T7510	T7509	amod	unique,functions
R4751	T7511	T7512	mark	as,acquired
R4752	T7512	T7499	advcl	acquired,integrated
R4753	T7513	T7514	det	the,genes
R4754	T7514	T7512	nsubj	genes,acquired
R4755	T7515	T7514	amod	evolving,genes
R4756	T7516	T7514	compound	TACC,genes
R4757	T7517	T7518	amod	additional,exons
R4758	T7518	T7512	dobj	exons,acquired
R4759	T7519	T7494	punct	.,seems
R4760	T7521	T7522	det	The,results
R4761	T7522	T7523	nsubj	results,provide
R4762	T7524	T7522	prep	of,results
R4763	T7525	T7526	det	the,analysis
R4764	T7526	T7524	pobj	analysis,of
R4765	T7527	T7526	nmod	pilot,analysis
R4766	T7528	T7529	amod	large,scale
R4767	T7529	T7526	nmod	scale,analysis
R4768	T7530	T7529	punct	-,scale
R4769	T7531	T7526	amod	proteomic,analysis
R4770	T7532	T7526	prep	in,analysis
R4771	T7533	T7534	compound	C.,elegans
R4772	T7534	T7532	pobj	elegans,in
R4773	T7535	T7534	cc	and,elegans
R4774	T7536	T7537	compound	D.,melanogaster
R4775	T7537	T7534	conj	melanogaster,elegans
R4776	T7538	T7539	amod	further,evidence
R4777	T7539	T7523	dobj	evidence,provide
R4778	T7540	T7539	amod	suggestive,evidence
R4779	T7541	T7539	prep	to,evidence
R4780	T7542	T7543	det	this,evolution
R4781	T7543	T7541	pobj	evolution,to
R4782	T7544	T7543	amod	functional,evolution
R4783	T7545	T7523	punct	.,provide
R4784	T7547	T7548	nmod	Yeast,analysis
R4785	T7548	T7551	nsubj	analysis,indicates
R4786	T7549	T7550	nummod	two,hybrid
R4787	T7550	T7548	compound	hybrid,analysis
R4788	T7552	T7553	mark	that,binds
R4789	T7553	T7551	ccomp	binds,indicates
R4790	T7554	T7553	nsubj	ceTAC,binds
R4791	T7555	T7553	advmod	directly,binds
R4792	T7556	T7553	prep	to,binds
R4793	T7557	T7558	compound	C.,lin15A
R4794	T7558	T7556	pobj	lin15A,to
R4795	T7559	T7558	compound	elegans,lin15A
R4796	T7560	T7558	punct	", ",lin15A
R4797	T7561	T7558	conj	lin36,lin15A
R4798	T7562	T7561	cc	and,lin36
R4799	T7563	T7561	conj	lin37,lin36
R4800	T7564	T7565	punct	[,28
R4801	T7565	T7551	parataxis	28,indicates
R4802	T7566	T7565	punct	],28
R4803	T7567	T7551	punct	.,indicates
R4804	T7569	T7570	det	These,proteins
R4805	T7570	T7571	nsubj	proteins,bridge
R4806	T7572	T7571	dobj	ceTAC,bridge
R4807	T7573	T7571	prep	to,bridge
R4808	T7574	T7575	amod	other,elements
R4809	T7575	T7573	pobj	elements,to
R4810	T7576	T7575	prep	of,elements
R4811	T7577	T7578	det	the,network
R4812	T7578	T7576	pobj	network,of
R4813	T7579	T7578	nmod	cytoskeleton,network
R4814	T7580	T7579	cc	and,cytoskeleton
R4815	T7581	T7579	conj	microtubule,cytoskeleton
R4816	T7582	T7573	punct	", ",to
R4817	T7583	T7584	advmod	as,as
R4818	T7584	T7573	cc	as,to
R4819	T7585	T7584	advmod	well,as
R4820	T7586	T7573	conj	to,to
R4821	T7587	T7586	pobj	components,to
R4822	T7588	T7587	prep	of,components
R4823	T7589	T7590	det	the,ribosome
R4824	T7590	T7588	pobj	ribosome,of
R4825	T7591	T7587	punct	", ",components
R4826	T7592	T7593	det	the,machinery
R4827	T7593	T7587	appos	machinery,components
R4828	T7594	T7595	nmod	histone,deacetylase
R4829	T7595	T7593	nmod	deacetylase,machinery
R4830	T7596	T7593	nmod	chromatin,machinery
R4831	T7597	T7596	amod	remodeling,chromatin
R4832	T7598	T7599	amod	such,as
R4833	T7599	T7593	prep	as,machinery
R4834	T7600	T7599	pobj	egr,as
R4835	T7601	T7600	punct	-,egr
R4836	T7602	T7600	nummod	1,egr
R4837	T7603	T7600	cc	and,egr
R4838	T7604	T7600	conj	lin,egr
R4839	T7605	T7604	punct	-,lin
R4840	T7606	T7604	nummod	53,lin
R4841	T7607	T7600	punct	(,egr
R4842	T7608	T7609	det	the,homologues
R4843	T7609	T7600	appos	homologues,egr
R4844	T7610	T7611	compound	C.,elegans
R4845	T7611	T7609	compound	elegans,homologues
R4846	T7612	T7609	prep	of,homologues
R4847	T7613	T7614	det	the,MTA
R4848	T7614	T7612	pobj	MTA,of
R4849	T7615	T7614	amod	human,MTA
R4850	T7616	T7614	punct	-,MTA
R4851	T7617	T7614	nummod	1,MTA
R4852	T7618	T7614	cc	and,MTA
R4853	T7619	T7614	conj	RbAP48,MTA
R4854	T7620	T7600	punct	),egr
R4855	T7621	T7586	punct	", ",to
R4856	T7622	T7586	cc	and,to
R4857	T7623	T7586	conj	to,to
R4858	T7624	T7625	compound	transcription,factors
R4859	T7625	T7623	pobj	factors,to
R4860	T7626	T7627	amod	such,as
R4861	T7627	T7625	prep	as,factors
R4862	T7628	T7629	det	the,homeobox
R4863	T7629	T7627	pobj	homeobox,as
R4864	T7630	T7629	compound	PAL1,homeobox
R4865	T7631	T7629	cc	and,homeobox
R4866	T7632	T7633	det	the,receptor
R4867	T7633	T7629	conj	receptor,homeobox
R4868	T7634	T7633	amod	nuclear,receptor
R4869	T7635	T7633	compound	hormone,receptor
R4870	T7636	T7633	appos	nhr,receptor
R4871	T7637	T7636	punct	-,nhr
R4872	T7638	T7636	nummod	86,nhr
R4873	T7639	T7640	punct	[,28
R4874	T7640	T7571	parataxis	28,bridge
R4875	T7641	T7640	punct	],28
R4876	T7642	T7643	punct	(,Fig.
R4877	T7643	T7571	parataxis	Fig.,bridge
R4878	T7644	T7643	nummod	6A,Fig.
R4879	T7645	T7643	punct	),Fig.
R4880	T7646	T7571	punct	.,bridge
R4881	T7648	T7649	advmod	Similarly,shown
R4882	T7650	T7649	punct	", ",shown
R4883	T7651	T7652	amod	large,scale
R4884	T7652	T7653	compound	scale,proteomics
R4885	T7653	T7649	nsubj	proteomics,shown
R4886	T7654	T7655	punct	[,29
R4887	T7655	T7653	parataxis	29,proteomics
R4888	T7656	T7655	punct	],29
R4889	T7657	T7649	aux	has,shown
R4890	T7658	T7659	mark	that,interacts
R4891	T7659	T7649	ccomp	interacts,shown
R4892	T7660	T7661	compound	Drosophila,TACC
R4893	T7661	T7659	nsubj	TACC,interacts
R4894	T7662	T7659	prep	with,interacts
R4895	T7663	T7664	nummod	two,proteins
R4896	T7664	T7662	pobj	proteins,with
R4897	T7665	T7664	punct	", ",proteins
R4898	T7666	T7667	det	the,protein
R4899	T7667	T7664	appos	protein,proteins
R4900	T7668	T7667	compound	RNA,protein
R4901	T7669	T7667	compound	binding,protein
R4902	T7670	T7667	appos	TBPH,protein
R4903	T7671	T7667	cc	and,protein
R4904	T7672	T7667	conj	CG14540,protein
R4905	T7673	T7674	punct	(,Fig.
R4906	T7674	T7664	parataxis	Fig.,proteins
R4907	T7675	T7674	nummod	6B,Fig.
R4908	T7676	T7674	punct	),Fig.
R4909	T7677	T7662	punct	", ",with
R4910	T7678	T7662	cc	and,with
R4911	T7679	T7680	advmod	thus,with
R4912	T7680	T7662	conj	with,with
R4913	T7681	T7680	advmod	indirectly,with
R4914	T7682	T7683	det	the,complex
R4915	T7683	T7680	pobj	complex,with
R4916	T7684	T7683	compound	Drosophila,complex
R4917	T7685	T7686	compound	SWI,SNF
R4918	T7686	T7683	compound	SNF,complex
R4919	T7687	T7686	punct	/,SNF
R4920	T7688	T7689	compound	chromatin,remodeling
R4921	T7689	T7683	compound	remodeling,complex
R4922	T7690	T7683	cc	and,complex
R4923	T7691	T7692	compound	DNA,damage
R4924	T7692	T7693	compound	damage,repair
R4925	T7693	T7694	compound	repair,machinery
R4926	T7694	T7683	conj	machinery,complex
R4927	T7695	T7649	punct	.,shown
R4928	T7697	T7698	advmod	Significantly,implicated
R4929	T7699	T7698	punct	", ",implicated
R4930	T7700	T7701	det	the,protein
R4943	T7713	T7712	amod	direct,interaction
R4944	T7714	T7712	prep	with,interaction
R4945	T7715	T7716	det	the,orthologue
R4946	T7716	T7714	pobj	orthologue,with
R4947	T7717	T7718	compound	C.,elegans
R4948	T7718	T7716	compound	elegans,orthologue
R4949	T7719	T7716	compound	BARD1,orthologue
R4950	T7720	T7721	punct	[,30
R4951	T7721	T7698	parataxis	30,implicated
R4952	T7722	T7721	punct	],30
R4953	T7723	T7698	punct	.,implicated
R4954	T7725	T7726	nsubjpass	It,noted
R4955	T7727	T7726	aux	should,noted
R4956	T7728	T7726	auxpass	be,noted
R4957	T7729	T7730	mark	that,missed
R4958	T7730	T7726	ccomp	missed,noted
R4959	T7731	T7732	det	a,number
R4960	T7732	T7730	nsubjpass	number,missed
R4961	T7733	T7732	prep	of,number
R4962	T7734	T7733	pobj	interactions,of
R4963	T7735	T7734	prep	with,interactions
R4964	T7736	T7737	det	the,proteins
R4965	T7737	T7735	pobj	proteins,with
R4966	T7738	T7737	compound	TACC,proteins
R4967	T7739	T7737	prep	from,proteins
R4968	T7740	T7741	det	these,organisms
R4969	T7741	T7739	pobj	organisms,from
R4970	T7742	T7730	aux	have,missed
R4971	T7743	T7730	advmod	probably,missed
R4972	T7744	T7730	auxpass	been,missed
R4973	T7745	T7730	agent	by,missed
R4974	T7746	T7747	det	these,methods
R4975	T7747	T7745	pobj	methods,by
R4976	T7748	T7749	amod	large,scale
R4977	T7749	T7747	compound	scale,methods
R4978	T7750	T7730	punct	", ",missed
R4979	T7751	T7730	prep	including,missed
R4980	T7752	T7753	det	the,interactions
R4981	T7753	T7751	pobj	interactions,including
R4982	T7754	T7755	advmod	well,documented
R4983	T7755	T7753	amod	documented,interactions
R4984	T7756	T7753	amod	direct,interactions
R4985	T7757	T7753	prep	with,interactions
R4986	T7758	T7759	det	the,kinases
R4987	T7759	T7757	pobj	kinases,with
R4988	T7760	T7759	compound	aurora,kinases
R4989	T7761	T7759	cc	and,kinases
R4990	T7762	T7763	det	the,family
R4991	T7763	T7759	conj	family,kinases
R4992	T7764	T7763	nmod	stu2,family
R4993	T7765	T7764	punct	/,stu2
R4994	T7766	T7764	appos	msps,stu2
R4995	T7767	T7764	punct	/,stu2
R4996	T7768	T7769	compound	ch,TOG
R4997	T7769	T7764	appos	TOG,stu2
R4998	T7770	T7769	punct	-,TOG
R4999	T7771	T7726	punct	.,noted
R5032	T7807	T7808	amod	Phylogenetic,profiling
R5033	T7808	T7809	nsubj	profiling,suggests
R5034	T7810	T7808	prep	from,profiling
R5035	T7811	T7812	det	these,maps
R5036	T7812	T7810	pobj	maps,from
R5037	T7813	T7812	compound	interaction,maps
R5038	T7814	T7815	nummod	two,sets
R5039	T7815	T7809	dobj	sets,suggests
R5040	T7816	T7815	amod	similar,sets
R5041	T7817	T7815	prep	of,sets
R5042	T7818	T7819	amod	predicted,interactions
R5043	T7819	T7817	pobj	interactions,of
R5044	T7820	T7815	prep	for,sets
R5045	T7821	T7822	compound	vertebrate,TACCs
R5046	T7822	T7820	pobj	TACCs,for
R5047	T7823	T7824	punct	(,6C
R5048	T7824	T7809	parataxis	6C,suggests
R5049	T7825	T7824	nmod	Fig.,6C
R5050	T7826	T7824	cc	and,6C
R5051	T7827	T7824	conj	6D,6C
R5052	T7828	T7824	punct	),6C
R5053	T7829	T7809	punct	.,suggests
R5054	T7831	T7832	advmod	Strikingly,have
R5055	T7833	T7832	punct	", ",have
R5056	T7834	T7832	advmod	however,have
R5057	T7835	T7832	punct	", ",have
R5058	T7836	T7837	det	the,proteins
R5059	T7837	T7832	nsubj	proteins,have
R5060	T7838	T7839	compound	C.,elegans
R5061	T7839	T7840	npadvmod	elegans,specific
R5062	T7840	T7837	amod	specific,proteins
R5063	T7841	T7837	appos	lin15A,proteins
R5064	T7842	T7841	punct	", ",lin15A
R5065	T7843	T7841	conj	lin36,lin15A
R5066	T7844	T7843	cc	and,lin36
R5067	T7845	T7843	conj	lin37,lin36
R5068	T7846	T7832	aux	do,have
R5069	T7847	T7832	neg	not,have
R5070	T7848	T7849	advmod	readily,discernible
R5071	T7849	T7850	amod	discernible,homologues
R5072	T7850	T7832	dobj	homologues,have
R5073	T7851	T7832	prep	in,have
R5074	T7852	T7851	pobj	vertebrates,in
R5075	T7853	T7852	cc	or,vertebrates
R5076	T7854	T7852	conj	Drosophila,vertebrates
R5077	T7855	T7832	punct	", ",have
R5078	T7856	T7857	mark	although,suggest
R5079	T7857	T7832	advcl	suggest,have
R5080	T7858	T7859	det	the,presence
R5081	T7859	T7857	nsubj	presence,suggest
R5082	T7860	T7859	prep	of,presence
R5083	T7861	T7862	det	a,domain
R5084	T7862	T7860	pobj	domain,of
R5085	T7863	T7864	compound	zinc,finger
R5086	T7864	T7862	compound	finger,domain
R5087	T7865	T7859	prep	in,presence
R5088	T7866	T7865	pobj	lin36,in
R5089	T7867	T7857	aux	may,suggest
R5090	T7868	T7869	mark	that,involved
R5091	T7869	T7857	ccomp	involved,suggest
R5092	T7870	T7871	det	this,protein
R5093	T7871	T7869	nsubjpass	protein,involved
R5094	T7872	T7869	auxpass	is,involved
R5095	T7873	T7869	advmod	directly,involved
R5096	T7874	T7869	prep	in,involved
R5097	T7875	T7874	pobj	transcription,in
R5098	T7876	T7869	cc	or,involved
R5099	T7877	T7869	conj	perform,involved
R5100	T7878	T7879	det	an,role
R5101	T7879	T7877	dobj	role,perform
R5102	T7880	T7879	compound	adaptor,role
R5103	T7881	T7879	amod	similar,role
R5104	T7882	T7881	prep	to,similar
R5105	T7883	T7884	npadvmod	LIM,containing
R5106	T7884	T7885	amod	containing,proteins
R5107	T7885	T7882	pobj	proteins,to
R5108	T7886	T7832	punct	.,have
R5109	T7888	T7889	prep	For,corresponds
R5110	T7890	T7891	det	the,proteins
R5111	T7891	T7888	pobj	proteins,For
R5112	T7892	T7893	npadvmod	DTACC,interacting
R5113	T7893	T7891	amod	interacting,proteins
R5114	T7894	T7889	punct	", ",corresponds
R5115	T7895	T7889	nsubj	TBPH,corresponds
R5116	T7896	T7889	prep	to,corresponds
R5117	T7897	T7896	pobj	TDP43,to
R5118	T7898	T7897	punct	", ",TDP43
R5119	T7899	T7900	det	a,protein
R5120	T7900	T7897	appos	protein,TDP43
R5121	T7901	T7900	acl	implicated,protein
R5122	T7902	T7901	prep	in,implicated
R5123	T7903	T7904	amod	transcriptional,regulation
R5124	T7904	T7902	pobj	regulation,in
R5125	T7905	T7904	cc	and,regulation
R5126	T7906	T7904	conj	splicing,regulation
R5127	T7907	T7908	punct	[,32
R5128	T7908	T7889	parataxis	32,corresponds
R5129	T7909	T7908	nummod	31,32
R5130	T7910	T7908	punct	",",32
R5131	T7911	T7908	punct	],32
R5132	T7912	T7889	punct	.,corresponds
R5133	T7914	T7915	advmod	However,is
R5134	T7916	T7915	punct	", ",is
R5135	T7917	T7918	det	the,assignment
R5136	T7918	T7915	nsubj	assignment,is
R5137	T7919	T7918	prep	of,assignment
R5138	T7920	T7921	det	the,homologue
R5139	T7921	T7919	pobj	homologue,of
R5140	T7922	T7921	amod	human,homologue
R5141	T7923	T7921	prep	of,homologue
R5142	T7924	T7923	pobj	CG14540,of
R5143	T7925	T7926	advmod	less,clear
R5144	T7926	T7915	acomp	clear,is
R5145	T7927	T7915	punct	", ",is
R5146	T7928	T7915	prep	with,is
R5147	T7929	T7930	det	the,matches
R5148	T7930	T7932	nsubj	matches,corresponding
R5149	T7931	T7930	amod	closest,matches
R5150	T7932	T7928	pcomp	corresponding,with
R5151	T7933	T7930	prep	in,matches
R5152	T7934	T7935	det	the,databases
R5153	T7935	T7933	pobj	databases,in
R5154	T7936	T7935	amod	human,databases
R5155	T7937	T7932	prep	to,corresponding
R5156	T7938	T7939	npadvmod	glutamine,rich
R5157	T7939	T7940	amod	rich,factors
R5158	T7940	T7937	pobj	factors,to
R5159	T7941	T7940	compound	transcription,factors
R5160	T7942	T7943	amod	such,as
R5161	T7943	T7940	prep	as,factors
R5162	T7944	T7943	pobj	CREB,as
R5163	T7945	T7944	cc	and,CREB
R5164	T7946	T7947	det	the,factor
R5165	T7947	T7944	conj	factor,CREB
R5166	T7948	T7949	compound	G,box
R5167	T7949	T7947	compound	box,factor
R5168	T7950	T7949	punct	-,box
R5169	T7951	T7947	compound	binding,factor
R5170	T7952	T7915	punct	.,is
R5177	T8333	T8332	prep	of,Comparison
R5178	T8334	T8333	pobj	modeled,of
R5179	T8335	T8332	prep	with,Comparison
R5180	T8336	T8337	advmod	experimentally,defined
R5181	T8337	T8335	pobj	defined,with
R5182	T8338	T8332	appos	interactions,Comparison
R5183	T8339	T8338	prep	of,interactions
R5184	T8340	T8341	det	the,proteins
R5185	T8341	T8339	pobj	proteins,of
R5186	T8342	T8341	compound	vertebrate,proteins
R5187	T8343	T8341	compound	TACC,proteins
R5188	T8345	T8346	det	The,data
R5189	T8346	T8348	nsubj	data,is
R5190	T8347	T8346	compound	interaction,data
R5191	T8348	T8353	ccomp	is,beginning
R5192	T8349	T8346	prep	for,data
R5193	T8350	T8351	det	the,TACCs
R5194	T8351	T8349	pobj	TACCs,for
R5195	T8352	T8351	compound	vertebrate,TACCs
R5196	T8354	T8355	advmod	relatively,limited
R5197	T8355	T8348	acomp	limited,is
R5198	T8356	T8353	punct	;,beginning
R5199	T8357	T8353	advmod	however,beginning
R5200	T8358	T8353	punct	", ",beginning
R5201	T8359	T8360	compound	interaction,networks
R5202	T8360	T8353	nsubj	networks,beginning
R5203	T8361	T8353	aux	are,beginning
R5204	T8362	T8353	advmod	now,beginning
R5205	T8363	T8364	aux	to,emerge
R5206	T8364	T8353	xcomp	emerge,beginning
R5207	T8365	T8353	punct	.,beginning
R5208	T8367	T8368	det	The,results
R5209	T8368	T8369	nsubj	results,indicate
R5210	T8370	T8368	prep	of,results
R5211	T8371	T8372	poss	our,analysis
R5212	T8372	T8370	pobj	analysis,of
R5213	T8373	T8372	amod	functional,analysis
R5214	T8374	T8368	punct	", ",results
R5215	T8375	T8376	advmod	as,as
R5216	T8376	T8368	cc	as,results
R5217	T8377	T8376	advmod	well,as
R5218	T8378	T8379	amod	other,data
R5219	T8379	T8368	conj	data,results
R5220	T8380	T8379	amod	published,data
R5221	T8381	T8369	advmod	clearly,indicate
R5222	T8382	T8383	mark	that,interact
R5223	T8383	T8369	ccomp	interact,indicate
R5224	T8384	T8385	det	the,TACCs
R5225	T8385	T8383	nsubj	TACCs,interact
R5226	T8386	T8385	compound	vertebrate,TACCs
R5227	T8387	T8383	prep	with,interact
R5228	T8388	T8387	pobj	proteins,with
R5229	T8389	T8390	dep	that,divided
R5230	T8390	T8388	relcl	divided,proteins
R5231	T8391	T8390	aux	can,divided
R5232	T8392	T8390	auxpass	be,divided
R5233	T8393	T8390	prep	into,divided
R5234	T8394	T8395	nummod	two,categories
R5235	T8395	T8393	pobj	categories,into
R5236	T8396	T8395	amod	broad,categories
R5237	T8397	T8369	punct	: ,indicate
R5238	T8398	T8399	meta	1,proteins
R5239	T8401	T8398	punct	),1
R5240	T8402	T8399	prep	with,proteins
R5241	T8403	T8402	pobj	roles,with
R5242	T8404	T8403	prep	in,roles
R5243	T8405	T8406	npadvmod	centrosome,mitotic
R5244	T8406	T8408	amod	mitotic,spindle
R5245	T8407	T8406	punct	/,mitotic
R5246	T8408	T8409	compound	spindle,dynamics
R5247	T8409	T8404	pobj	dynamics,in
R5248	T8410	T8399	punct	", ",proteins
R5249	T8411	T8399	cc	and,proteins
R5250	T8412	T8413	meta	2,proteins
R5251	T8413	T8399	conj	proteins,proteins
R5252	T8414	T8412	punct	),2
R5253	T8415	T8413	acl	involved,proteins
R5254	T8416	T8415	prep	in,involved
R5255	T8417	T8418	compound	gene,regulation
R5256	T8418	T8416	pobj	regulation,in
R5257	T8419	T8415	punct	", ",involved
R5258	T8420	T8421	preconj	either,at
R5259	T8421	T8415	prep	at,involved
R5260	T8422	T8423	det	the,level
R5261	T8423	T8421	pobj	level,at
R5262	T8424	T8423	prep	of,level
R5263	T8425	T8424	pobj	transcription,of
R5264	T8426	T8425	punct	", ",transcription
R5265	T8427	T8425	cc	or,transcription
R5266	T8428	T8429	amod	subsequent,processing
R5267	T8429	T8425	conj	processing,transcription
R5268	T8430	T8429	compound	RNA,processing
R5269	T8431	T8429	cc	and,processing
R5270	T8432	T8429	conj	translation,processing
R5271	T8433	T8434	punct	[,3
R5272	T8434	T8415	parataxis	3,involved
R5273	T8435	T8434	punct	",",3
R5274	T8436	T8434	appos	5,3
R5275	T8437	T8438	punct	-,7
R5276	T8438	T8436	prep	7,5
R5277	T8439	T8434	punct	",",3
R5278	T8440	T8434	appos	15,3
R5279	T8441	T8434	punct	",",3
R5280	T8442	T8434	appos	19,3
R5281	T8443	T8444	punct	-,21
R5282	T8444	T8442	prep	21,19
R5283	T8445	T8434	punct	",",3
R5284	T8446	T8434	appos	24,3
R5285	T8447	T8434	punct	",",3
R5286	T8448	T8434	appos	25,3
R5287	T8449	T8434	punct	",",3
R5288	T8450	T8434	appos	33,3
R5289	T8451	T8434	punct	",",3
R5290	T8452	T8434	appos	34,3
R5291	T8453	T8434	punct	],3
R5292	T8454	T8413	punct	.,proteins
R5293	T8456	T8457	nsubj	Many,appear
R5294	T8458	T8456	prep	of,Many
R5295	T8459	T8460	det	these,proteins
R5296	T8460	T8458	pobj	proteins,of
R5297	T8461	T8457	aux	do,appear
R5298	T8462	T8457	neg	not,appear
R5299	T8463	T8464	aux	to,interact
R5300	T8464	T8457	xcomp	interact,appear
R5301	T8465	T8464	advmod	directly,interact
R5302	T8466	T8464	prep	with,interact
R5303	T8467	T8468	det	the,TACCs
R5304	T8468	T8466	pobj	TACCs,with
R5305	T8469	T8468	compound	protostome,TACCs
R5306	T8470	T8457	punct	", ",appear
R5307	T8471	T8457	cc	but,appear
R5308	T8472	T8473	aux	would,expected
R5309	T8473	T8457	conj	expected,appear
R5310	T8474	T8473	auxpass	be,expected
R5311	T8475	T8476	aux	to,be
R5312	T8476	T8473	xcomp	be,expected
R5313	T8477	T8476	prep	in,be
R5314	T8478	T8479	det	the,complex
R5315	T8479	T8477	pobj	complex,in
R5316	T8480	T8479	amod	same,complex
R5317	T8481	T8479	compound	protein,complex
R5318	T8482	T8483	punct	(,6D
R5319	T8483	T8473	parataxis	6D,expected
R5320	T8484	T8483	nmod	Fig.,6D
R5321	T8485	T8483	nummod	6C,6D
R5322	T8486	T8483	punct	",",6D
R5323	T8487	T8483	punct	),6D
R5324	T8488	T8457	punct	.,appear
R5325	T8490	T8491	amod	Significant,analysis
R5326	T8491	T8492	nsubjpass	analysis,published
R5327	T8493	T8491	prep	of,analysis
R5328	T8494	T8495	det	the,association
R5329	T8495	T8493	pobj	association,of
R5330	T8496	T8495	prep	of,association
R5331	T8497	T8498	det	the,TACCs
R5332	T8498	T8496	pobj	TACCs,of
R5333	T8499	T8495	prep	with,association
R5334	T8500	T8501	det	the,centrosome
R5335	T8501	T8499	pobj	centrosome,with
R5336	T8502	T8495	cc	and,association
R5337	T8503	T8504	det	the,dynamics
R5338	T8504	T8495	conj	dynamics,association
R5339	T8505	T8504	prep	of,dynamics
R5340	T8506	T8507	amod	mitotic,spindle
R5341	T8507	T8508	compound	spindle,assembly
R5342	T8508	T8505	pobj	assembly,of
R5343	T8509	T8491	prep	from,analysis
R5344	T8510	T8509	pobj	yeast,from
R5345	T8511	T8509	prep	to,from
R5346	T8512	T8511	pobj	humans,to
R5347	T8513	T8492	aux	has,published
R5348	T8514	T8492	auxpass	been,published
R5349	T8515	T8516	punct	[,5
R5350	T8516	T8492	parataxis	5,published
R5351	T8517	T8516	punct	",",5
R5352	T8518	T8516	appos	6,5
R5353	T8519	T8516	punct	",",5
R5354	T8520	T8516	appos	21,5
R5355	T8521	T8522	punct	-,24
R5356	T8522	T8520	prep	24,21
R5357	T8523	T8516	punct	],5
R5358	T8524	T8492	punct	.,published
R5359	T8526	T8527	prep	From,seems
R5360	T8528	T8529	det	this,analysis
R5361	T8529	T8526	pobj	analysis,From
R5362	T8530	T8527	punct	", ",seems
R5363	T8531	T8527	nsubj	it,seems
R5364	T8532	T8527	oprd	likely,seems
R5365	T8533	T8534	mark	that,retained
R5366	T8534	T8527	ccomp	retained,seems
R5367	T8535	T8536	det	the,protein
R5368	T8536	T8534	nsubj	protein,retained
R5369	T8537	T8536	compound	vertebrate,protein
R5370	T8538	T8536	compound	TACC3,protein
R5371	T8539	T8534	aux	has,retained
R5372	T8540	T8541	det	this,function
R5373	T8541	T8534	dobj	function,retained
R5374	T8542	T8541	amod	direct,function
R5375	T8543	T8541	amod	ancestral,function
R5376	T8544	T8527	punct	", ",seems
R5377	T8545	T8527	prep	based,seems
R5378	T8546	T8545	prep	upon,based
R5379	T8547	T8548	poss	its,location
R5380	T8548	T8546	pobj	location,upon
R5381	T8549	T8548	prep	in,location
R5382	T8550	T8551	det	these,structures
R5383	T8551	T8549	pobj	structures,in
R5384	T8552	T8548	prep	during,location
R5385	T8553	T8552	pobj	mitosis,during
R5386	T8554	T8555	punct	[,27
R5387	T8555	T8548	parataxis	27,location
R5388	T8556	T8555	punct	],27
R5389	T8557	T8548	punct	", ",location
R5390	T8558	T8559	poss	its,interaction
R5391	T8559	T8548	conj	interaction,location
R5392	T8560	T8559	amod	strong,interaction
R5393	T8561	T8559	prep	with,interaction
R5394	T8562	T8563	compound	Aurora,A
R5395	T8563	T8561	pobj	A,with
R5396	T8564	T8563	compound	Kinase,A
R5397	T8565	T8559	punct	", ",interaction
R5398	T8566	T8559	cc	and,interaction
R5399	T8567	T8568	det	the,observation
R5400	T8568	T8559	conj	observation,interaction
R5401	T8569	T8570	mark	that,is
R5402	T8570	T8568	acl	is,observation
R5403	T8571	T8570	nsubj	it,is
R5404	T8572	T8573	det	the,protein
R5405	T8573	T8570	attr	protein,is
R5406	T8574	T8573	advmod	only,protein
R5407	T8575	T8573	amod	human,protein
R5408	T8576	T8573	compound	TACC,protein
R5409	T8577	T8573	acl	phosphorylated,protein
R5410	T8578	T8577	agent	by,phosphorylated
R5411	T8579	T8580	det	this,enzyme
R5412	T8580	T8578	pobj	enzyme,by
R5413	T8581	T8582	punct	[,21
R5414	T8582	T8568	parataxis	21,observation
R5415	T8583	T8582	punct	],21
R5416	T8584	T8527	punct	.,seems
R5417	T8586	T8587	advmod	However,suggests
R5418	T8588	T8587	punct	", ",suggests
R5419	T8589	T8590	det	the,variability
R5420	T8590	T8587	nsubj	variability,suggests
R5421	T8591	T8590	prep	of,variability
R5422	T8592	T8593	det	the,domain
R5423	T8593	T8591	pobj	domain,of
R5424	T8594	T8593	amod	central,domain
R5425	T8595	T8593	prep	of,domain
R5426	T8596	T8597	det	the,orthologues
R5427	T8597	T8595	pobj	orthologues,of
R5428	T8598	T8597	compound	vertebrate,orthologues
R5429	T8599	T8587	punct	", ",suggests
R5430	T8600	T8601	mark	that,acquired
R5431	T8601	T8587	ccomp	acquired,suggests
R5432	T8602	T8601	nsubj	TACC3,acquired
R5433	T8603	T8601	aux	may,acquired
R5434	T8604	T8601	advmod	also,acquired
R5435	T8605	T8601	aux	have,acquired
R5436	T8606	T8607	amod	additional,functions
R5437	T8607	T8601	dobj	functions,acquired
R5438	T8608	T8606	punct	", ",additional
R5439	T8609	T8606	cc	and,additional
R5440	T8610	T8611	prep	in,specific
R5441	T8611	T8606	conj	specific,additional
R5442	T8612	T8613	det	some,instances
R5443	T8613	T8610	pobj	instances,in
R5444	T8614	T8611	punct	", ",specific
R5445	T8615	T8611	npadvmod	species,specific
R5446	T8616	T8611	punct	-,specific
R5447	T8617	T8587	punct	.,suggests
R5448	T8619	T8620	prep	For,acquired
R5449	T8621	T8619	pobj	instance,For
R5450	T8622	T8620	punct	", ",acquired
R5451	T8623	T8620	prep	in,acquired
R5452	T8624	T8625	compound	X.,laevis
R5453	T8625	T8623	pobj	laevis,in
R5454	T8626	T8620	punct	", ",acquired
R5455	T8627	T8628	det	the,protein
R5456	T8628	T8620	nsubj	protein,acquired
R5457	T8629	T8628	compound	maskin,protein
R5458	T8630	T8620	aux	has,acquired
R5459	T8631	T8632	det	a,site
R5460	T8632	T8620	dobj	site,acquired
R5461	T8633	T8632	compound	binding,site
R5462	T8634	T8632	prep	for,site
R5463	T8635	T8636	det	the,protein
R5464	T8636	T8634	pobj	protein,for
R5465	T8637	T8636	compound	eIF4E,protein
R5466	T8638	T8632	punct	", ",site
R5467	T8639	T8632	cc	and,site
R5468	T8640	T8641	advmod	thus,function
R5469	T8641	T8632	conj	function,site
R5470	T8642	T8641	det	a,function
R5471	T8643	T8641	prep	in,function
R5472	T8644	T8645	det	the,control
R5473	T8645	T8643	pobj	control,in
R5474	T8646	T8645	amod	coordinated,control
R5475	T8647	T8645	prep	of,control
R5476	T8648	T8647	pobj	polyadenylation,of
R5477	T8649	T8648	cc	and,polyadenylation
R5478	T8650	T8648	conj	translation,polyadenylation
R5479	T8651	T8641	prep	in,function
R5480	T8652	T8653	det	the,oocyte
R5481	T8653	T8651	pobj	oocyte,in
R5482	T8654	T8653	compound	Xenopus,oocyte
R5483	T8655	T8656	punct	[,35
R5484	T8656	T8620	parataxis	35,acquired
R5485	T8657	T8656	nummod	8,35
R5486	T8658	T8656	punct	",",35
R5487	T8659	T8656	punct	],35
R5488	T8660	T8620	punct	.,acquired
R5489	T8662	T8663	det	A,study
R5490	T8663	T8665	nsubj	study,suggested
R5491	T8664	T8663	amod	recent,study
R5492	T8665	T8667	ccomp	suggested,is
R5493	T8666	T8665	aux	has,suggested
R5494	T8668	T8669	mark	that,be
R5495	T8669	T8665	ccomp	be,suggested
R5496	T8670	T8671	det	this,function
R5497	T8671	T8669	nsubj	function,be
R5498	T8672	T8669	aux	may,be
R5499	T8673	T8669	acomp	unique,be
R5500	T8674	T8673	prep	to,unique
R5501	T8675	T8674	pobj	maskin,to
R5502	T8676	T8667	punct	: ,is
R5503	T8677	T8678	mark	although,is
R5504	T8678	T8667	advcl	is,is
R5505	T8679	T8678	nsubj	it,is
R5506	T8680	T8678	acomp	unclear,is
R5507	T8681	T8682	mark	whether,interact
R5508	T8682	T8678	ccomp	interact,is
R5509	T8683	T8684	det	the,proteins
R5510	T8684	T8682	nsubj	proteins,interact
R5511	T8685	T8684	amod	other,proteins
R5512	T8686	T8684	compound	vertebrate,proteins
R5513	T8687	T8684	compound	TACC3,proteins
R5514	T8688	T8682	prep	with,interact
R5515	T8689	T8690	det	the,complex
R5516	T8690	T8688	pobj	complex,with
R5517	T8691	T8692	compound	eIF4E,CPEB
R5518	T8692	T8690	compound	CPEB,complex
R5519	T8693	T8692	punct	/,CPEB
R5520	T8694	T8667	punct	", ",is
R5521	T8695	T8696	det	the,isoform
R5522	T8696	T8667	nsubj	isoform,is
R5523	T8697	T8696	amod	human,isoform
R5524	T8698	T8696	compound	TACC1A,isoform
R5525	T8699	T8667	acomp	unable,is
R5526	T8700	T8701	aux	to,interact
R5527	T8701	T8699	xcomp	interact,unable
R5528	T8702	T8701	prep	with,interact
R5529	T8703	T8704	det	the,complex
R5530	T8704	T8702	pobj	complex,with
R5531	T8705	T8706	compound	eIF4E,CPEB
R5532	T8706	T8704	compound	CPEB,complex
R5533	T8707	T8706	punct	/,CPEB
R5534	T8708	T8667	punct	.,is
R5535	T8710	T8711	advmod	Instead,evolved
R5536	T8712	T8711	punct	", ",evolved
R5537	T8713	T8714	det	some,isoforms
R5538	T8714	T8711	nsubj	isoforms,evolved
R5539	T8715	T8714	compound	TACC1,isoforms
R5540	T8716	T8711	aux	have,evolved
R5541	T8717	T8718	det	a,function
R5542	T8718	T8711	dobj	function,evolved
R5543	T8719	T8718	amod	related,function
R5544	T8720	T8719	punct	", ",related
R5545	T8721	T8719	cc	but,related
R5546	T8722	T8719	conj	distinct,related
R5547	T8723	T8711	prep	by,evolved
R5548	T8724	T8725	advmod	directly,interacting
R5549	T8725	T8723	pcomp	interacting,by
R5550	T8726	T8725	prep	with,interacting
R5551	T8727	T8726	pobj	elements,with
R5552	T8728	T8727	prep	of,elements
R5553	T8729	T8730	det	the,machinery
R5554	T8730	T8728	pobj	machinery,of
R5555	T8731	T8732	nmod	RNA,splicing
R5556	T8732	T8730	nmod	splicing,machinery
R5557	T8733	T8732	cc	and,splicing
R5558	T8734	T8732	conj	transport,splicing
R5559	T8735	T8736	punct	[,19
R5560	T8736	T8711	parataxis	19,evolved
R5561	T8737	T8736	punct	],19
R5562	T8738	T8711	punct	.,evolved
R5563	T8740	T8741	aux	To,characterize
R5564	T8741	T8743	advcl	characterize,used
R5565	T8742	T8741	advmod	further,characterize
R5566	T8744	T8745	det	the,functions
R5567	T8745	T8741	dobj	functions,characterize
R5568	T8746	T8745	amod	evolving,functions
R5569	T8747	T8745	prep	of,functions
R5570	T8748	T8749	det	the,proteins
R5571	T8749	T8747	pobj	proteins,of
R5572	T8750	T8749	compound	TACC,proteins
R5573	T8751	T8743	punct	", ",used
R5574	T8752	T8743	nsubj	we,used
R5575	T8753	T8743	aux	have,used
R5576	T8754	T8755	det	an,method
R5577	T8755	T8743	dobj	method,used
R5578	T8756	T8755	amod	unbiased,method
R5579	T8757	T8755	nmod	yeast,method
R5580	T8758	T8759	nummod	two,hybrid
R5581	T8759	T8755	compound	hybrid,method
R5582	T8760	T8755	compound	screening,method
R5583	T8761	T8762	aux	to,identify
R5584	T8762	T8743	advcl	identify,used
R5585	T8763	T8762	dobj	proteins,identify
R5586	T8764	T8765	dep	that,bind
R5587	T8765	T8763	relcl	bind,proteins
R5588	T8766	T8765	prep	to,bind
R5589	T8767	T8768	det	the,proteins
R5590	T8768	T8766	pobj	proteins,to
R5591	T8769	T8768	amod	human,proteins
R5592	T8770	T8768	compound	TACC,proteins
R5593	T8771	T8772	punct	[,34
R5594	T8772	T8743	parataxis	34,used
R5595	T8773	T8772	nummod	3,34
R5596	T8774	T8772	punct	",",34
R5597	T8775	T8772	punct	],34
R5598	T8776	T8743	punct	.,used
R5599	T8778	T8779	prep	In,identified
R5600	T8780	T8781	det	a,screen
R5601	T8781	T8778	pobj	screen,In
R5602	T8782	T8781	prep	of,screen
R5603	T8783	T8784	det	a,library
R5604	T8784	T8782	pobj	library,of
R5605	T8785	T8784	nmod	MATCHMAKER,library
R5606	T8786	T8787	amod	fetal,brain
R5607	T8787	T8784	compound	brain,library
R5608	T8788	T8789	punct	(,Clontech
R5609	T8789	T8784	parataxis	Clontech,library
R5610	T8790	T8789	compound	BD,Clontech
R5611	T8791	T8789	compound	Biosciences,Clontech
R5612	T8792	T8789	punct	),Clontech
R5613	T8793	T8779	punct	", ",identified
R5614	T8794	T8779	prep	in,identified
R5615	T8795	T8794	pobj	addition,in
R5616	T8796	T8795	prep	to,addition
R5617	T8797	T8796	pcomp	isolating,to
R5618	T8798	T8799	det	the,acetyltransferase
R5619	T8799	T8797	dobj	acetyltransferase,isolating
R5620	T8800	T8799	compound	histone,acetyltransferase
R5621	T8801	T8799	appos	hGCN5L2,acetyltransferase
R5622	T8802	T8803	punct	[,34
R5623	T8803	T8797	parataxis	34,isolating
R5624	T8804	T8803	punct	],34
R5625	T8805	T8779	punct	", ",identified
R5626	T8806	T8779	nsubj	we,identified
R5627	T8807	T8779	advmod	also,identified
R5628	T8808	T8809	det	the,isoform
R5629	T8809	T8779	dobj	isoform,identified
R5630	T8810	T8809	compound	β3,isoform
R5631	T8811	T8809	prep	of,isoform
R5632	T8812	T8813	compound	retinoid,X
R5633	T8813	T8815	compound	X,β
R5634	T8814	T8813	punct	-,X
R5635	T8815	T8811	pobj	β,of
R5636	T8816	T8815	compound	receptor,β
R5637	T8817	T8779	prep	as,identified
R5638	T8818	T8819	det	a,protein
R5639	T8819	T8817	pobj	protein,as
R5640	T8820	T8821	dep	that,interacts
R5641	T8821	T8819	relcl	interacts,protein
R5642	T8822	T8821	prep	with,interacts
R5643	T8823	T8824	det	the,domain
R5644	T8824	T8822	pobj	domain,with
R5645	T8825	T8824	compound	TACC,domain
R5646	T8826	T8824	prep	of,domain
R5647	T8827	T8826	pobj	TACC2,of
R5648	T8828	T8779	punct	.,identified
R5649	T8830	T8831	mark	As,shown
R5650	T8831	T8832	advcl	shown,confirmed
R5651	T8833	T8831	prep	in,shown
R5652	T8834	T8833	pobj	Fig.,in
R5653	T8835	T8834	nummod	7,Fig.
R5654	T8836	T8832	punct	", ",confirmed
R5655	T8837	T8838	det	this,interaction
R5656	T8838	T8832	nsubjpass	interaction,confirmed
R5657	T8839	T8832	auxpass	is,confirmed
R5658	T8840	T8841	advmod	in,vitro
R5659	T8841	T8832	advmod	vitro,confirmed
R5660	T8842	T8832	prep	by,confirmed
R5661	T8843	T8844	npadvmod	GST,pull
R5662	T8844	T8846	amod	pull,analysis
R5663	T8845	T8844	punct	-,pull
R5664	T8846	T8842	pobj	analysis,by
R5665	T8847	T8844	prt	down,pull
R5666	T8848	T8832	punct	.,confirmed
R5667	T8850	T8851	advmod	Significantly,is
R5668	T8852	T8851	punct	", ",is
R5669	T8853	T8851	nsubj	RXRβ,is
R5670	T8854	T8855	det	a,family
R5671	T8855	T8851	attr	family,is
R5672	T8856	T8855	amod	close,family
R5673	T8857	T8855	amod	relative,family
R5674	T8858	T8855	prep	of,family
R5675	T8859	T8860	det	the,receptor
R5676	T8860	T8858	pobj	receptor,of
R5677	T8861	T8860	amod	nuclear,receptor
R5678	T8862	T8860	compound	hormone,receptor
R5679	T8863	T8860	punct	", ",receptor
R5680	T8864	T8860	appos	nhr,receptor
R5681	T8865	T8864	punct	-,nhr
R5682	T8866	T8864	nummod	86,nhr
R5683	T8867	T8860	punct	", ",receptor
R5684	T8868	T8860	prep	from,receptor
R5685	T8869	T8870	compound	C.,elegans
R5686	T8870	T8868	pobj	elegans,from
R5687	T8871	T8870	punct	", ",elegans
R5688	T8872	T8873	dep	which,interacts
R5689	T8873	T8870	relcl	interacts,elegans
R5690	T8874	T8873	prep	with,interacts
R5691	T8875	T8876	det	the,protein
R5692	T8876	T8874	pobj	protein,with
R5693	T8877	T8876	compound	ceTAC,protein
R5694	T8878	T8876	compound	binding,protein
R5695	T8879	T8876	appos	lin36,protein
R5696	T8880	T8881	punct	(,Fig.
R5697	T8881	T8873	parataxis	Fig.,interacts
R5698	T8882	T8881	nummod	6A,Fig.
R5699	T8883	T8881	punct	),Fig.
R5700	T8884	T8851	punct	.,is
R5701	T8886	T8887	nsubj	This,suggests
R5702	T8888	T8889	mark	that,evolved
R5703	T8889	T8887	ccomp	evolved,suggests
R5704	T8890	T8891	mark	while,require
R5705	T8891	T8889	advcl	require,evolved
R5706	T8892	T8893	compound	protostome,TACCs
R5707	T8893	T8891	nsubj	TACCs,require
R5708	T8894	T8891	aux	may,require
R5709	T8895	T8896	amod	additional,factors
R5710	T8896	T8891	dobj	factors,require
R5711	T8897	T8896	compound	protein,factors
R5712	T8898	T8899	aux	to,interact
R5713	T8899	T8891	advcl	interact,require
R5714	T8900	T8899	prep	with,interact
R5715	T8901	T8902	amod	such,components
R5716	T8902	T8900	pobj	components,with
R5717	T8903	T8889	punct	", ",evolved
R5718	T8904	T8905	det	the,TACCs
R5719	T8905	T8889	nsubj	TACCs,evolved
R5720	T8906	T8905	prep	in,TACCs
R5721	T8907	T8908	amod	higher,organisms
R5722	T8908	T8906	pobj	organisms,in
R5723	T8909	T8889	aux	may,evolved
R5724	T8910	T8889	aux	have,evolved
R5725	T8911	T8912	det	the,ability
R5726	T8912	T8889	dobj	ability,evolved
R5727	T8913	T8914	aux	to,interact
R5728	T8914	T8912	acl	interact,ability
R5729	T8915	T8914	advmod	directly,interact
R5730	T8916	T8914	prep	with,interact
R5731	T8917	T8916	pobj	some,with
R5732	T8918	T8917	prep	of,some
R5733	T8919	T8920	det	the,proteins
R5734	T8920	T8918	pobj	proteins,of
R5735	T8921	T8914	prep	in,interact
R5736	T8922	T8923	det	the,map
R5737	T8923	T8921	pobj	map,in
R5738	T8924	T8923	amod	predicted,map
R5739	T8925	T8923	compound	interaction,map
R5740	T8926	T8927	punct	(,Fig.
R5741	T8927	T8887	parataxis	Fig.,suggests
R5742	T8928	T8927	nummod	6E,Fig.
R5743	T8929	T8927	punct	),Fig.
R5744	T8930	T8887	punct	.,suggests
R5745	T8932	T8933	advmod	Indeed,appears
R5746	T8934	T8933	punct	", ",appears
R5747	T8935	T8933	nsubj	this,appears
R5748	T8936	T8937	aux	to,linked
R5749	T8937	T8933	xcomp	linked,appears
R5750	T8938	T8937	auxpass	be,linked
R5751	T8939	T8937	advmod	directly,linked
R5752	T8940	T8937	prep	to,linked
R5753	T8941	T8942	det	the,acquisition
R5754	T8942	T8940	pobj	acquisition,to
R5755	T8943	T8942	prep	of,acquisition
R5756	T8944	T8945	amod	new,domains
R5757	T8945	T8943	pobj	domains,of
R5758	T8946	T8942	cc	and,acquisition
R5759	T8947	T8942	conj	duplication,acquisition
R5760	T8948	T8947	prep	of,duplication
R5761	T8949	T8950	det	the,precursor
R5762	T8950	T8948	pobj	precursor,of
R5763	T8951	T8950	compound	chordate,precursor
R5764	T8952	T8950	compound	TACC,precursor
R5765	T8953	T8933	punct	.,appears
R5766	T8955	T8956	prep	In,was
R5767	T8957	T8955	pobj	fact,In
R5768	T8958	T8956	punct	", ",was
R5769	T8959	T8960	det	the,function
R5770	T8960	T8956	nsubj	function,was
R5771	T8961	T8960	amod	first,function
R5772	T8962	T8960	amod	identified,function
R5773	T8963	T8960	prep	of,function
R5774	T8964	T8965	det	a,protein
R5775	T8965	T8963	pobj	protein,of
R5776	T8966	T8965	compound	vertebrate,protein
R5777	T8967	T8965	compound	TACC,protein
R5778	T8968	T8956	prep	as,was
R5779	T8969	T8970	det	a,coactivator
R5780	T8970	T8968	pobj	coactivator,as
R5781	T8971	T8970	amod	transcriptional,coactivator
R5782	T8972	T8970	acl	acting,coactivator
R5783	T8973	T8972	prep	through,acting
R5784	T8974	T8975	det	a,interaction
R5785	T8975	T8973	pobj	interaction,through
R5786	T8976	T8975	amod	direct,interaction
R5787	T8977	T8975	prep	with,interaction
R5788	T8978	T8979	det	the,factor
R5789	T8979	T8977	pobj	factor,with
R5790	T8980	T8979	compound	ARNT,factor
R5791	T8981	T8979	compound	transcription,factor
R5792	T8982	T8983	punct	[,7
R5793	T8983	T8956	parataxis	7,was
R5794	T8984	T8983	punct	],7
R5795	T8985	T8956	punct	.,was
R5796	T8987	T8988	nsubj	It,is
R5797	T8989	T8988	advmod	also,is
R5798	T8990	T8988	acomp	intriguing,is
R5799	T8991	T8992	mark	that,interacts
R5800	T8992	T8988	ccomp	interacts,is
R5801	T8993	T8994	det	the,repeat
R5802	T8994	T8992	nsubj	repeat,interacts
R5803	T8995	T8996	npadvmod	deuterostome,specific
R5804	T8996	T8994	amod	specific,repeat
R5805	T8997	T8994	compound	SDP,repeat
R5806	T8998	T8992	prep	with,interacts
R5807	T8999	T8998	pobj	GAS41,with
R5808	T9000	T8999	punct	", ",GAS41
R5809	T9001	T9002	det	a,factor
R5810	T9002	T8999	appos	factor,GAS41
R5811	T9003	T9004	compound	component,accessory
R5812	T9004	T9002	compound	accessory,factor
R5813	T9005	T9004	punct	/,accessory
R5814	T9006	T9002	prep	of,factor
R5815	T9007	T9008	det	the,complex
R5816	T9008	T9006	pobj	complex,of
R5817	T9009	T9008	amod	human,complex
R5818	T9010	T9011	compound	SWI,SNF
R5819	T9011	T9008	compound	SNF,complex
R5820	T9012	T9011	punct	/,SNF
R5821	T9013	T9014	compound	chromatin,remodeling
R5822	T9014	T9008	compound	remodeling,complex
R5823	T9015	T9016	punct	[,15
R5824	T9016	T8988	parataxis	15,is
R5825	T9017	T9016	nummod	3,15
R5826	T9018	T9016	punct	",",15
R5827	T9019	T9016	punct	],15
R5828	T9020	T8988	punct	.,is
R5829	T9022	T9023	mark	Although,is
R5830	T9023	T9025	advcl	is,indicate
R5831	T9024	T9023	expl	there,is
R5832	T9026	T9027	det	a,homologue
R5833	T9027	T9023	attr	homologue,is
R5834	T9028	T9029	compound	D.,melanogaster
R5835	T9029	T9027	compound	melanogaster,homologue
R5836	T9030	T9027	prep	of,homologue
R5837	T9031	T9030	pobj	GAS41,of
R5838	T9032	T9027	punct	", ",homologue
R5839	T9033	T9027	appos	dmGAS41,homologue
R5840	T9034	T9025	punct	", ",indicate
R5841	T9035	T9036	det	the,database
R5842	T9036	T9025	nsubj	database,indicate
R5843	T9037	T9038	amod	large,scale
R5844	T9038	T9039	nmod	scale,interaction
R5845	T9039	T9036	compound	interaction,database
R5846	T9040	T9039	amod	proteomic,interaction
R5847	T9041	T9025	aux	does,indicate
R5848	T9042	T9025	neg	not,indicate
R5849	T9043	T9044	det	a,interaction
R5850	T9044	T9025	dobj	interaction,indicate
R5851	T9045	T9044	amod	direct,interaction
R5852	T9046	T9044	prep	of,interaction
R5853	T9047	T9046	pobj	dmGAS41,of
R5854	T9048	T9044	prep	with,interaction
R5855	T9049	T9048	pobj	DTACC,with
R5856	T9050	T9025	punct	.,indicate
R5857	T9052	T9053	nsubj	This,be
R5858	T9054	T9053	aux	may,be
R5859	T9055	T9053	prep	due,be
R5860	T9056	T9055	pcomp	to,due
R5861	T9057	T9058	det	the,lack
R5862	T9058	T9055	pobj	lack,due
R5863	T9059	T9058	prep	of,lack
R5864	T9060	T9061	det	the,region
R5865	T9061	T9059	pobj	region,of
R5866	T9062	T9063	compound	SDP,repeat
R5867	T9063	T9061	compound	repeat,region
R5868	T9064	T9058	prep	in,lack
R5869	T9065	T9066	det	the,protein
R5870	T9066	T9064	pobj	protein,in
R5871	T9067	T9066	compound	Drosophila,protein
R5872	T9068	T9066	compound	TACC,protein
R5873	T9069	T9053	punct	.,be
R5874	T9071	T9072	nsubj	This,suggests
R5875	T9073	T9072	advmod	further,suggests
R5876	T9074	T9075	mark	that,gained
R5877	T9075	T9072	advcl	gained,suggests
R5878	T9076	T9077	det	the,TACCs
R5879	T9077	T9075	nsubj	TACCs,gained
R5880	T9078	T9077	compound	vertebrate,TACCs
R5881	T9079	T9075	aux	have,gained
R5882	T9080	T9081	det	the,ability
R5883	T9081	T9075	dobj	ability,gained
R5884	T9082	T9081	amod	specific,ability
R5885	T9083	T9084	aux	to,interact
R5886	T9084	T9081	acl	interact,ability
R5887	T9085	T9084	amod	direct,interact
R5888	T9086	T9084	prep	with,interact
R5889	T9087	T9088	amod	transcriptional,complexes
R5890	T9088	T9086	pobj	complexes,with
R5891	T9089	T9088	amod	regulatory,complexes
R5892	T9090	T9075	punct	", ",gained
R5893	T9091	T9075	cc	and,gained
R5894	T9092	T9093	mark	that,required
R5895	T9093	T9075	conj	required,gained
R5896	T9094	T9095	amod	bridging,protein
R5897	T9095	T9093	nsubjpass	protein,required
R5898	T9096	T9095	punct	(,protein
R5899	T9097	T9095	nmod	s,protein
R5900	T9098	T9095	punct	),protein
R5901	T9099	T9093	auxpass	are,required
R5902	T9100	T9101	neg	no,longer
R5903	T9101	T9093	advmod	longer,required
R5904	T9102	T9072	punct	.,suggests
R5905	T9104	T9105	advmod	Thus,integrated
R5906	T9106	T9105	punct	", ",integrated
R5907	T9107	T9108	advmod	where,composed
R5908	T9108	T9105	advcl	composed,integrated
R5909	T9109	T9110	det	the,protein
R5910	T9110	T9108	nsubjpass	protein,composed
R5911	T9111	T9110	compound	ceTAC,protein
R5912	T9112	T9108	auxpass	is,composed
R5913	T9113	T9108	advmod	only,composed
R5914	T9114	T9108	prep	of,composed
R5915	T9115	T9116	det	the,domain
R5916	T9116	T9114	pobj	domain,of
R5917	T9117	T9116	compound	TACC,domain
R5918	T9118	T9105	punct	", ",integrated
R5919	T9119	T9120	det	the,members
R5920	T9120	T9105	nsubj	members,integrated
R5921	T9121	T9122	advmod	significantly,larger
R5922	T9122	T9120	amod	larger,members
R5923	T9123	T9120	compound	TACC,members
R5924	T9124	T9120	compound	family,members
R5925	T9125	T9120	prep	in,members
R5926	T9126	T9127	amod	higher,protostomes
R5927	T9127	T9125	pobj	protostomes,in
R5928	T9128	T9127	cc	and,protostomes
R5929	T9129	T9127	conj	deuterostomes,protostomes
R5930	T9130	T9105	aux	may,integrated
R5931	T9131	T9105	aux	have,integrated
R5932	T9132	T9133	nummod	one,functions
R5933	T9133	T9105	dobj	functions,integrated
R5934	T9134	T9132	cc	or,one
R5935	T9135	T9132	conj	more,one
R5936	T9136	T9133	prep	of,functions
R5937	T9137	T9138	det	the,protein
R5938	T9138	T9136	pobj	protein,of
R5939	T9139	T9138	amod	bridging,protein
R5940	T9140	T9138	punct	(,protein
R5941	T9141	T9138	prep	in,protein
R5942	T9142	T9143	det	this,case
R5943	T9143	T9141	pobj	case,in
R5944	T9144	T9138	appos	lin15A,protein
R5945	T9145	T9144	punct	", ",lin15A
R5946	T9146	T9144	conj	lin36,lin15A
R5947	T9147	T9146	cc	or,lin36
R5948	T9148	T9146	conj	lin37,lin36
R5949	T9149	T9105	punct	),integrated
R5950	T9150	T9105	punct	.,integrated
R5951	T9152	T9153	nsubj	This,explain
R5952	T9154	T9153	aux	may,explain
R5953	T9155	T9153	advmod	also,explain
R5954	T9156	T9157	det	the,absence
R5955	T9157	T9153	dobj	absence,explain
R5956	T9158	T9157	prep	of,absence
R5957	T9159	T9160	nmod	lin15A,homologues
R5958	T9160	T9158	pobj	homologues,of
R5959	T9161	T9159	punct	", ",lin15A
R5960	T9162	T9159	conj	lin36,lin15A
R5961	T9163	T9162	cc	and,lin36
R5962	T9164	T9162	conj	lin37,lin36
R5963	T9165	T9157	prep	in,absence
R5964	T9166	T9167	amod	higher,organisms
R5965	T9167	T9165	pobj	organisms,in
R5966	T9168	T9153	punct	", ",explain
R5967	T9169	T9170	mark	as,were
R5968	T9170	T9153	advcl	were,explain
R5969	T9171	T9170	nsubj	they,were
R5970	T9172	T9173	neg	no,longer
R5971	T9173	T9170	advmod	longer,were
R5972	T9174	T9170	prep	under,were
R5973	T9175	T9176	amod	selective,pressure
R5974	T9176	T9174	pobj	pressure,under
R5975	T9177	T9176	amod	evolutionary,pressure
R5976	T9178	T9179	aux	to,remain
R5977	T9179	T9176	acl	remain,pressure
R5978	T9180	T9179	prep	within,remain
R5979	T9181	T9182	det	the,complex
R5980	T9182	T9180	pobj	complex,within
R5981	T9183	T9170	punct	", ",were
R5982	T9184	T9170	cc	and,were
R5983	T9185	T9186	advmod	thus,lost
R5984	T9186	T9170	conj	lost,were
R5985	T9187	T9186	prep	in,lost
R5986	T9188	T9189	det	the,genome
R5987	T9189	T9187	pobj	genome,in
R5988	T9190	T9189	amod	evolving,genome
R5989	T9191	T9153	punct	.,explain
R2693	T4414	T4412	punct	),Fig.
R2694	T4415	T4398	punct	", ",located
R2695	T4416	T4417	advmod	further,suggesting
R2696	T4417	T4398	advcl	suggesting,located
R2697	T4418	T4419	mark	that,transposed
R2698	T4419	T4417	ccomp	transposed,suggesting
R2699	T4420	T4421	det	this,cluster
R8996	T13875	T13876	advmod	In,vitro
R8997	T13876	T13877	amod	vitro,interaction
R8998	T13878	T13877	prep	of,interaction
R4931	T7701	T7698	nsubjpass	protein,implicated
R4932	T7702	T7701	compound	ceTAC,protein
R4933	T7703	T7698	aux	has,implicated
R4934	T7704	T7698	advmod	also,implicated
R4935	T7705	T7698	advmod	recently,implicated
R4936	T7706	T7698	auxpass	been,implicated
R4937	T7707	T7698	prep	in,implicated
R4938	T7708	T7709	compound	DNA,repair
R4939	T7709	T7707	pobj	repair,in
R4940	T7710	T7698	prep	through,implicated
R4941	T7711	T7712	poss	its,interaction
R4942	T7712	T7710	pobj	interaction,through
R5000	T7773	T7774	prep	Because,predict
R5001	T7775	T7773	pcomp	of,Because
R5002	T7776	T7777	det	the,conservation
R5003	T7777	T7773	pobj	conservation,Because
R5004	T7778	T7777	amod	evolutionary,conservation
R5005	T7779	T7777	prep	of,conservation
R5006	T7780	T7781	det	the,domain
R5007	T7781	T7779	pobj	domain,of
R5008	T7782	T7781	compound	TACC,domain
R5009	T7783	T7774	punct	", ",predict
R5010	T7784	T7774	nsubj	we,predict
R5011	T7785	T7774	aux	would,predict
R5012	T7786	T7787	mark	that,observed
R5013	T7787	T7774	ccomp	observed,predict
R5014	T7788	T7787	nsubjpass	some,observed
R5015	T7789	T7788	prep	of,some
R5016	T7790	T7791	det	the,interactions
R5017	T7791	T7789	pobj	interactions,of
R5018	T7792	T7791	amod	functional,interactions
R5019	T7793	T7791	acl	seen,interactions
R5020	T7794	T7793	prep	in,seen
R5021	T7795	T7796	compound	C.,elegans
R5022	T7796	T7794	pobj	elegans,in
R5023	T7797	T7796	cc	and,elegans
R5024	T7798	T7799	compound	D.,melanogaster
R5025	T7799	T7796	conj	melanogaster,elegans
R5026	T7800	T7787	aux	would,observed
R5027	T7801	T7787	auxpass	be,observed
R5028	T7802	T7787	prep	in,observed
R5029	T7803	T7804	amod	higher,animals
R5030	T7804	T7802	pobj	animals,in
R5031	T7805	T7774	punct	.,predict
R1010	T1805	T1796	prep	in,found
R1011	T1806	T1807	amod	other,organisms
R1012	T1807	T1805	pobj	organisms,in
R1013	T1808	T1807	amod	non-metazoan,organisms
R1014	T1809	T1796	punct	.,found
R1015	T1818	T1819	nsubj	a,s
R1016	T1836	T1835	compound	ra,nch
R1017	T1837	T1835	prep	of,nch
R1018	T1838	T1837	pobj	life,of
R1019	T1839	T1833	punct	", ",identified
R1020	T1840	T1841	det	a,gene
R1021	T1841	T1833	nsubjpass	gene,identified
R1022	T1842	T1841	amod	single,gene
R1023	T1843	T1841	compound	TACC,gene
R1024	T1844	T1833	auxpass	was,identified
R2673	T4392	T4391	acomp	paralogous,are
R2674	T4393	T4392	prep	with,paralogous
R2675	T4394	T4393	pobj	4p16,with
R2676	T4395	T4381	punct	.,separate
R2677	T4397	T4398	advmod	Interestingly,located
R2678	T4399	T4398	punct	", ",located
R2679	T4400	T4401	det	these,clusters
R2680	T4401	T4398	nsubjpass	clusters,located
R2681	T4402	T4401	nummod	three,clusters
R2682	T4403	T4398	auxpass	are,located
R2683	T4404	T4398	prep	on,located
R2684	T4405	T4406	amod	different,chromosomes
R2685	T4406	T4404	pobj	chromosomes,on
R2686	T4407	T4398	prep	in,located
R2687	T4408	T4407	pobj	mouse,in
R2688	T4409	T4408	cc	and,mouse
R2689	T4410	T4408	conj	rat,mouse
R2690	T4411	T4412	punct	(,Fig.
R2691	T4412	T4398	parataxis	Fig.,located
R2692	T4413	T4412	nummod	2,Fig.
R2700	T4421	T4419	nsubjpass	cluster,transposed
R2701	T4422	T4421	prep	of,cluster
R2702	T4423	T4422	pobj	genes,of
R2703	T4424	T4419	auxpass	was,transposed
R2704	T4425	T4419	prep	into,transposed
R2705	T4426	T4427	det	this,region
R2706	T4427	T4425	pobj	region,into
R2707	T4428	T4419	prep	after,transposed
R2708	T4429	T4430	det	the,divergence
R2709	T4430	T4428	pobj	divergence,after
R2710	T4431	T4432	compound	primate,rodent
R2711	T4432	T4430	compound	rodent,divergence
R2712	T4433	T4432	punct	/,rodent
R2714	T4437	T4438	mark	Because,provide
R3363	T5125	T5123	prep	of,resolution
R3364	T5126	T5127	det	the,evolution
R3365	T5127	T5125	pobj	evolution,of
R3366	T5128	T5127	amod	initial,evolution
R3367	T5129	T5127	prep	of,evolution
R3368	T5130	T5131	det	these,segment
R3369	T5131	T5129	pobj	segment,of
R3370	T5132	T5131	amod	paralogous,segment
R3371	T5133	T5120	aux	will,await
R3372	T5134	T5135	det	the,sequencing
R3373	T5135	T5120	dobj	sequencing,await
R3374	T5136	T5135	prep	of,sequencing
R3375	T5137	T5138	det	the,genomes
R3376	T5138	T5136	pobj	genomes,of
R3377	T5139	T5138	nmod	amphioxus,genomes
R3378	T5140	T5139	cc	and,amphioxus
R3379	T5141	T5139	conj	lamprey,amphioxus
R3380	T5142	T5138	punct	", ",genomes
R3381	T5143	T5144	dep	which,have
R3382	T5144	T5138	relcl	have,genomes
R3383	T5145	T5144	advmod	only,have
R3384	T5146	T5147	nummod	one,gene
R3385	T5147	T5144	dobj	gene,have
R3386	T5148	T5147	compound	FGFR,gene
R3387	T5149	T5144	punct	", ",have
R3388	T5150	T5144	cc	and,have
R3389	T5151	T5152	advmod	therefore,contain
R3390	T5152	T5144	conj	contain,have
R3391	T5153	T5152	aux	should,contain
R3392	T5154	T5152	advmod	only,contain
R3393	T5155	T5156	nummod	one,copy
R3394	T5156	T5152	dobj	copy,contain
R3395	T5157	T5156	prep	of,copy
R3396	T5158	T5159	det	the,genes
R3397	T5159	T5157	pobj	genes,of

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T1442	345-352	NCBITaxon:species	denotes	species
T1443	392-400	SO_EXT:biological_sequence	denotes	sequence
T1444	413-418	SO_EXT:0000704	denotes	genes
T1445	531-540	SO_EXT:biological_sequence	denotes	sequences
T1446	552-561	NCBITaxon:1	denotes	organisms
T1447	604-608	SO_EXT:cDNA	denotes	cDNA
T1448	636-645	SO_EXT:biological_sequence	denotes	sequences
T1449	655-665	NCBITaxon:7742	denotes	vertebrate
T1450	666-673	NCBITaxon:species	denotes	species
T1451	679-692	NCBITaxon:7586	denotes	echinodermate
T1452	693-722	NCBITaxon:7668	denotes	Strongylocentrotus purpuratus
T1453	731-741	NCBITaxon:33317	denotes	protostome
T1454	742-748	NCBITaxon:6960	denotes	insect
T1455	749-766	NCBITaxon:7165	denotes	Anopheles gambiae
T1456	811-823	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T1457	836-841	SO_EXT:0000704	denotes	genes
T1458	845-853	NCBITaxon:33208	denotes	metazoan
T1459	908-912	SO_EXT:cDNA	denotes	cDNA
T1460	913-919	SO_EXT:0001026	denotes	genome
T1461	946-955	NCBITaxon:1	denotes	organisms
T1462	997-1002	SO_EXT:0000704	denotes	genes
T1463	1089-1097	SO_EXT:biological_sequence	denotes	sequence
T1464	1105-1115	NCBITaxon:33213	denotes	bilaterian
T1465	1116-1125	NCBITaxon:33208	denotes	metazoans
T1466	1135-1143	NCBITaxon:6073	denotes	Cnidaria
T1467	1147-1155	NCBITaxon:6040	denotes	Porifera
T1468	1179-1187	SO_EXT:biological_sequence	denotes	sequence
T1469	1210-1219	NCBITaxon:1	denotes	organisms
T1470	1247-1256	SO_EXT:biological_sequence	denotes	sequences
T1471	1277-1283	SO_EXT:0000417	denotes	domain
T1472	1316-1324	NCBITaxon:33208	denotes	metazoan
T1473	1325-1334	NCBITaxon:1	denotes	organisms
T1474	1847-1848	SO_EXT:0001080	denotes	c
T1475	1850-1851	CHEBI_PR_EXT:protein	denotes	r
T1476	1853-1855	CHEBI_PR_EXT:protein	denotes	te
T1477	1857-1859	NCBITaxon:7711	denotes	ra
T1478	1886-1890	SO_EXT:0000704	denotes	gene
T1479	1913-1919	SO_EXT:0001026	denotes	genome
T1480	1927-1938	NCBITaxon:7712	denotes	urochordate
T1481	1939-1957	NCBITaxon:7719	denotes	Ciona intestinalis
T1482	1983-1991	SO_EXT:biological_sequence	denotes	sequence
T1483	2016-2035	NCBITaxon:7729	denotes	Halocynthia rortezi
T1484	2036-2039	SO_EXT:0000345	denotes	EST
T1485	2112-2116	SO_EXT:0000704	denotes	gene
T1486	2136-2144	NCBITaxon:7711	denotes	chordate
T1487	2200-2208	NCBITaxon:7711	denotes	chordate
T1488	2209-2215	SO_EXT:0001026	denotes	genome
T1489	2304-2315	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1490	2323-2331	NCBITaxon:7711	denotes	chordate
T1491	2332-2338	SO_EXT:0001026	denotes	genome
T1492	2353-2364	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1493	2413-2418	SO_EXT:0000704	denotes	genes
T1494	2424-2434	SO_EXT:sequence_duplication_process	denotes	duplicated
T1495	2489-2494	SO_EXT:0000704	denotes	genes
T1496	2527-2537	NCBITaxon:7742	denotes	vertebrate
T1497	2538-2544	SO_EXT:0001026	denotes	genome
T1498	2568-2578	NCBITaxon:31031	denotes	pufferfish
T1499	2579-2596	NCBITaxon:31033	denotes	Takifugu rubripes
T1500	2609-2614	SO_EXT:0000704	denotes	genes
T1501	2636-2641	NCBITaxon:9606	denotes	human
T1502	2642-2647	PR_EXT:000016006	denotes	TACC1
T1503	2695-2702	SO_EXT:0001026	denotes	genomic
T1504	2703-2714	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1505	2722-2738	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal loci
T1506	2752-2757	SO_EXT:0000704	denotes	genes
T1507	2795-2799	SO_EXT:0000704	denotes	gene
T1508	2818-2823	PR_EXT:000016008	denotes	TACC3
T1509	2852-2857	SO_EXT:0000704	denotes	genes
T1510	2877-2888	NCBITaxon:31033	denotes	T. rubripes
T1511	2904-2909	SO_EXT:0000704	denotes	genes
T1512	2930-2941	NCBITaxon:31033	denotes	T. rubripes
T1513	2942-2953	SO_EXT:0000855	denotes	orthologues
T1514	2957-2962	NCBITaxon:9606	denotes	human
T1515	2963-2968	PR_EXT:000016007	denotes	TACC2
T1516	2973-2978	PR_EXT:000016008	denotes	TACC3
T1517	3003-3008	SO_EXT:0000704	denotes	genes
T1518	3060-3065	PR_EXT:000016006	denotes	TACC1
T1519	3104-3114	SO:0000857	denotes	homologous
T1520	3139-3146	SO_EXT:sequence_coding_function	denotes	encodes
T1521	3181-3188	CHEBI_PR_EXT:protein	denotes	protein
T1522	3203-3207	SO_EXT:0000704	denotes	gene
T1523	3211-3218	SO_EXT:sequence_coding_function	denotes	encoded
T1524	3225-3230	SO_EXT:0000147	denotes	exons
T1525	3253-3254	CHEBI_SO_EXT:base	denotes	b
T1526	3262-3270	NCBITaxon:31032	denotes	Takifugu
T1527	3271-3279	SO_EXT:0001248	denotes	Scaffold
T1528	3340-3348	SO_EXT:biological_sequence	denotes	sequence
T1529	3353-3357	SO_EXT:0000704	denotes	gene
T1530	3419-3424	SO_EXT:0000147	denotes	exons
T1531	3457-3463	SO_EXT:0000188	denotes	intron
T1532	3464-3468	SO_EXT:0000147	denotes	exon
T1533	3507-3511	SO_EXT:0000704	denotes	gene
T1534	3562-3572	NCBITaxon:31031	denotes	pufferfish
T1535	3652-3660	NCBITaxon:1	denotes	organism
T1536	3729-3733	CL_GO_EXT:cell	denotes	cell
T1537	3768-3784	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal loci
T1538	3824-3829	SO_EXT:0000704	denotes	genes
T1539	3861-3872	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1540	3880-3899	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T1541	3915-3922	NCBITaxon:32443	denotes	teleost
T1542	3923-3928	PR_EXT:000016006	denotes	TACC1
T1543	3969-3976	SO_EXT:0001026	denotes	genomic
T1544	3977-3988	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1545	4010-4017	NCBITaxon:32443	denotes	teleost
T1546	4055-4066	NCBITaxon:31033	denotes	T. rubripes
T1547	4131-4136	PR_EXT:000016008	denotes	TACC3
T1548	4182-4192	NCBITaxon:7742	denotes	vertebrate
T1549	4193-4200	SO_EXT:0001026	denotes	genomic
T1550	4201-4212	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1551	4236-4247	NCBITaxon:7742	denotes	vertebrates
T1552	4277-4283	GO:0008380	denotes	splice
T1553	4277-4292	SO_EXT:alternative_splice_variant	denotes	splice variants
T1554	4296-4301	PR_EXT:000016006	denotes	TACC1
T1555	4306-4311	PR_EXT:000016007	denotes	TACC2
T1556	4315-4327	NCBITaxon:10090	denotes	Mus musculus
T1557	4337-4345	SO_EXT:sequence_assembly_entity_or_process	denotes	assembly
T1558	4377-4388	SO_EXT:0000855	denotes	orthologues
T1559	4392-4397	PR_EXT:000016006	denotes	TACC1
T1560	4405-4420	NCBITaxon:10116	denotes	Rattus norvegus
T1561	4446-4454	SO_EXT:biological_sequence	denotes	sequence
T1562	4468-4473	NCBITaxon:10088	denotes	mouse
T1563	4474-4484	GO_SO_EXT:chromosome	denotes	chromosome
T1564	4474-4486	GO:0000805	denotes	chromosome X
T1565	4493-4497	SO_EXT:0000704	denotes	gene
T1566	4524-4529	NCBITaxon:10088	denotes	mouse
T1567	4530-4535	PR_EXT:000016006	denotes	TACC1
T1568	4577-4582	NCBITaxon:10088	denotes	mouse
T1569	4586-4592	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T1570	4637-4643	SO_EXT:0000188	denotes	intron
T1571	4661-4671	GO:0010467	denotes	expression
T1572	4698-4703	NCBITaxon:10088	denotes	mouse
T1573	4704-4707	CHEBI_SO_EXT:RNA	denotes	RNA
T1574	4711-4713	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	rt
T1575	4766-4774	SO_EXT:biological_sequence	denotes	sequence
T1576	4780-4800	SO_EXT:0000043	denotes	processed pseudogene
T1577	4813-4818	PR_EXT:000016006	denotes	TACC1
T1578	4819-4830	SO_EXT:0000336	denotes	pseudogenes
T1579	4858-4859	CHEBI_SO_EXT:base	denotes	b
T1580	4867-4885	GO_SO_EXT:centromere_or_centromeric_region_or_centromeric_orientation	denotes	centromeric region
T1581	4879-4888	_FRAGMENT	denotes	region of
T1582	4895-4905	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosome
T1583	4889-4894	NCBITaxon:9606	denotes	human
T1584	4971-4973	SO_EXT:0000028	denotes	bp
T1585	4981-4986	PR_EXT:000016006	denotes	TACC1
T1586	4987-5009	SO_EXT:0000205	denotes	3' untranslated region
T1587	4992-5002	GO:0006412	denotes	translated
T1588	5014-5025	SO_EXT:0000336	denotes	pseudogenes
T1589	5043-5048	PR_EXT:000016007	denotes	TACC2
T1590	5052-5057	PR_EXT:000016008	denotes	TACC3
T1591	5081-5090	NCBITaxon:40674	denotes	mammalian
T1592	5091-5098	NCBITaxon:species	denotes	species
T2571	5121-5131	NCBITaxon:7742	denotes	vertebrate
T2572	5132-5137	PR_EXT:000016008	denotes	TACC3
T2573	5138-5149	SO_EXT:0000855	denotes	orthologues
T2574	5214-5219	PR_EXT:000016008	denotes	TACC3
T2575	5220-5231	SO_EXT:0000855	denotes	orthologues
T2576	5277-5285	SO_EXT:biological_sequence	denotes	sequence
T2577	5323-5327	SO_EXT:0000704	denotes	gene
T2578	5360-5378	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal region
T2579	5399-5403	SO_EXT:0000704	denotes	gene
T2580	5419-5429	SO_EXT:sequence_duplication_process	denotes	duplicated
T2581	5443-5453	NCBITaxon:7742	denotes	vertebrate
T2582	5490-5501	NCBITaxon:31033	denotes	T. rubripes
T2583	5503-5510	NCBITaxon:9989	denotes	rodents
T2584	5515-5521	NCBITaxon:9606	denotes	humans
T2585	5547-5557	NCBITaxon:7742	denotes	vertebrate
T2586	5558-5563	PR_EXT:000016008	denotes	TACC3
T2587	5614-5621	SO_EXT:0001026	denotes	genomic
T2588	5622-5633	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T2589	5673-5677	SO_EXT:0000704	denotes	gene
T2590	5741-5748	SO_EXT:sequence_cloning_process	denotes	cloning
T2591	5787-5808	NCBITaxon:9986	denotes	Oryctolagus cuniculus
T2592	5871-5872	CHEBI_SO_EXT:base	denotes	b
T2593	5873-5877	SO_EXT:cDNA	denotes	cDNA
T2594	5931-5936	PR_EXT:000016008	denotes	TACC3
T2595	5986-5990	SO_EXT:0000704	denotes	gene
T2596	6014-6015	CHEBI_SO_EXT:base	denotes	b
T2597	6016-6026	SO_EXT:0000673	denotes	transcript
T2598	6052-6058	SO_EXT:sequence_cloning_process	denotes	cloned
T2599	6059-6063	SO_EXT:cDNA	denotes	cDNA
T2600	6122-6130	SO_EXT:biological_sequence	denotes	sequence
T2601	6134-6139	NCBITaxon:9606	denotes	human
T2602	6144-6149	NCBITaxon:10088	denotes	mouse
T2603	6150-6155	PR_EXT:000016008	denotes	TACC3
T2604	6213-6219	NCBITaxon:9986	denotes	rabbit
T2605	6220-6225	PR_EXT:000016008	denotes	TACC3
T2606	6226-6230	SO_EXT:cDNA	denotes	cDNA
T2607	6271-6276	SO_EXT:sequence_cloning_process	denotes	clone
T2608	6290-6296	NCBITaxon:9986	denotes	rabbit
T2609	6297-6302	PR_EXT:000016008	denotes	TACC3
T2610	6303-6311	SO_EXT:biological_sequence	denotes	sequence
T2611	6346-6351	NCBITaxon:9606	denotes	human
T2612	6356-6361	NCBITaxon:10088	denotes	mouse
T2613	6362-6367	PR_EXT:000016008	denotes	TACC3
T2614	6403-6413	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T2615	6418-6428	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T2616	6444-6449	NCBITaxon:9606	denotes	human
T2617	6454-6459	NCBITaxon:10088	denotes	mouse
T2618	6460-6465	PR_EXT:000016008	denotes	TACC3
T2619	6466-6474	CHEBI_PR_EXT:protein	denotes	proteins
T2620	6486-6495	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T2621	6540-6548	SO_EXT:biological_sequence	denotes	sequence
T2622	6572-6577	SO_EXT:0000704	denotes	genes
T2623	6593-6602	SO:0000993	denotes	consensus
T2624	6603-6618	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotide
T2625	6619-6625	SO_EXT:0000112	denotes	primer
T2626	6720-6730	CHEBI_SO_EXT:methionine	denotes	methionine
T2627	6738-6743	PR_EXT:000016008	denotes	TACC3
T2628	6744-6749	SO_EXT:cDNA	denotes	cDNAs
T2629	6755-6763	NCBITaxon:9443	denotes	primates
T2630	6768-6775	NCBITaxon:9989	denotes	rodents
T2631	6788-6794	SO_EXT:0000112	denotes	primer
T2632	6840-6846	SO_EXT:0000112	denotes	primer
T2633	6913-6914	CHEBI_SO_EXT:base	denotes	b
T2634	6915-6926	SO_EXT:0000006	denotes	PCR product
T2635	6932-6938	NCBITaxon:9986	denotes	rabbit
T2636	6939-6944	UBERON:0000955	denotes	brain
T2637	6945-6949	SO_EXT:cDNA	denotes	cDNA
T2638	6953-6955	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	rt
T2639	7006-7015	SO:0000993	denotes	consensus
T2640	7016-7020	SO_EXT:cDNA	denotes	cDNA
T2641	7029-7031	SO_EXT:0000028	denotes	bp
T2642	7057-7067	SO_EXT:0000673	denotes	transcript
T2643	7081-7082	CHEBI_SO_EXT:base	denotes	b
T2644	7107-7115	SO_EXT:biological_sequence	denotes	sequence
T2645	7209-7217	SO_EXT:biological_sequence	denotes	sequence
T2646	7224-7242	GO:0000380	denotes	alternative splice
T2647	7224-7250	SO_EXT:alternative_splice_variant	denotes	alternative splice product
T2648	7275-7286	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T2649	7294-7299	PR_EXT:000016008	denotes	TACC3
T2650	7300-7304	SO_EXT:0000704	denotes	gene
T2651	7343-7349	NCBITaxon:9986	denotes	rabbit
T2652	7361-7371	SO_EXT:0000673	denotes	transcript
T2653	7384-7390	NCBITaxon:9986	denotes	rabbit
T2654	7391-7394	CHEBI_SO_EXT:RNA	denotes	RNA
T2655	7414-7434	SO_EXT:0002138	denotes	predicted transcript
T2656	7447-7452	PR_EXT:000016008	denotes	TACC3
T2657	7453-7461	SO_EXT:biological_sequence	denotes	sequence
T2658	7519-7530	CHEBI_SO_EXT:nucleotide	denotes	nucleotides
T2659	7566-7574	SO_EXT:biological_sequence	denotes	sequence
T2660	7619-7623	SO_EXT:cDNA	denotes	cDNA
T2661	7624-7633	SO_EXT:biological_sequence	denotes	sequences
T2662	7799-7805	NCBITaxon:9986	denotes	rabbit
T2663	7822-7828	NCBITaxon:9986	denotes	rabbit
T2664	7829-7834	PR_EXT:000016008	denotes	TACC3
T2665	7835-7843	SO_EXT:biological_sequence	denotes	sequence
T2666	7945-7950	PR_EXT:000016008	denotes	TACC3
T2667	7951-7962	SO_EXT:0000855	denotes	orthologues
T2668	7982-7996	NCBITaxon:8355	denotes	Xenopus laevis
T2669	8024-8029	PR_EXT:000016008	denotes	TACC3
T2670	8030-8039	SO_EXT:biological_sequence	denotes	sequences
T2671	8043-8058	NCBITaxon:10116	denotes	Rattus norvegus
T2672	8060-8073	NCBITaxon:9031	denotes	Gallus gallus
T2673	8075-8094	NCBITaxon:8364	denotes	Silurana tropicalis
T2674	8096-8107	NCBITaxon:7955	denotes	Danio rerio
T2675	8112-8123	NCBITaxon:31033	denotes	T. rubripes
T2676	8228-8236	SO_EXT:biological_sequence	denotes	sequence
T3361	8290-8295	PR_EXT:000001856	denotes	RHAMM
T3362	8296-8300	SO_EXT:0000704	denotes	gene
T3363	8325-8336	SO_EXT:0001080	denotes	coiled coil
T3364	8337-8341	SO_EXT:0000704	denotes	gene
T3365	8349-8354	NCBITaxon:9606	denotes	Human
T3366	8355-8360	PR_EXT:000001856	denotes	RHAMM
T3367	8493-8513	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal location
T3368	8525-8531	NCBITaxon:9606	denotes	humans
T3369	8555-8563	SO_EXT:biological_sequence	denotes	sequence
T3370	8582-8593	SO_EXT:0001080	denotes	coiled coil
T3371	8594-8600	SO_EXT:0000417	denotes	domain
T3372	8613-8619	SO_EXT:0000417	denotes	domain
T3373	8628-8639	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T3374	8631-8639	CL_GO_EXT:cell	denotes	cellular
T3375	8640-8652	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T3376	8660-8665	PR_EXT:000001856	denotes	RHAMM
T3377	8666-8673	CHEBI_PR_EXT:protein	denotes	protein
T3378	8681-8691	GO:0005813	denotes	centrosome
T3379	8705-8710	PR_EXT:000001856	denotes	RHAMM
T3380	8883-8893	NCBITaxon:7742	denotes	vertebrate
T3381	8894-8900	SO_EXT:0001026	denotes	genome
T3382	8931-8936	PR_EXT:000001856	denotes	RHAMM
T3383	8937-8948	SO_EXT:0000855	denotes	orthologues
T3384	8961-8966	SO_EXT:0000704	denotes	genes
T3385	8970-8979	NCBITaxon:33208	denotes	metazoans
T3386	9022-9033	SO_EXT:0001080	denotes	coiled coil
T3387	9090-9095	PR_EXT:000001856	denotes	RHAMM
T3388	9096-9100	SO_EXT:0000704	denotes	gene
T3389	9108-9121	NCBITaxon:33511	denotes	deuterostomes
T3390	9132-9136	SO_EXT:cDNA	denotes	cDNA
T3391	9144-9151	SO_EXT:0001026	denotes	genomic
T3392	9152-9160	SO_EXT:biological_sequence	denotes	sequence
T3393	9186-9201	NCBITaxon:7719	denotes	C. intestinalis
T3394	9206-9211	PR_EXT:000001856	denotes	RHAMM
T3395	9212-9216	SO_EXT:0000704	denotes	gene
T3396	9235-9242	NCBITaxon:6960	denotes	insects
T3397	9246-9255	NCBITaxon:6231	denotes	nematodes
T3398	9281-9286	PR_EXT:000001856	denotes	RHAMM
T3399	9292-9297	SO_EXT:0000704	denotes	genes
T3400	9317-9327	NCBITaxon:33317	denotes	protostome
T3401	9328-9340	NCBITaxon:33511	denotes	deuterostome
T3402	9377-9390	NCBITaxon:7586	denotes	echinodermata
T3403	9391-9402	NCBITaxon:7712	denotes	urochordate
T3404	9441-9449	SO_EXT:biological_sequence	denotes	sequence
T3405	9479-9490	SO_EXT:0001080	denotes	coiled coil
T3406	9491-9499	CHEBI_PR_EXT:protein	denotes	proteins
T3407	9528-9533	PR_EXT:000001856	denotes	RHAMM
T3408	9558-9564	SO_EXT:0000417	denotes	domain
T3409	9604-9612	CHEBI_PR_EXT:protein	denotes	proteins
T3410	9620-9631	SO_EXT:0001080	denotes	coiled coil
T3411	9698-9702	SO_EXT:0000704	denotes	gene
T3973	10316-10326	GO_SO_EXT:chromosome	denotes	chromosome
T3974	10345-10350	NCBITaxon:9606	denotes	human
T3975	10351-10361	GO_SO_EXT:chromosome	denotes	chromosome
T3976	10425-10437	NCBITaxon_EXT:invertebrate	denotes	invertebrate
T3977	10483-10487	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T3978	10493-10497	SO_EXT:0000704	denotes	gene
T3979	10544-10555	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T3980	10591-10601	_FRAGMENT	denotes	paralogous
T3981	10614-10622	SO_EXT:0000854	denotes	segments
T3982	10602-10622	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T3983	10718-10722	SO_EXT:0000704	denotes	gene
T3984	10726-10737	NCBITaxon:7742	denotes	vertebrates
T3985	10763-10781	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal region
T3986	10785-10790	PR_EXT:000001451	denotes	FGFR4
T3987	10848-10853	PR_EXT:000001856	denotes	RHAMM
T3988	10854-10858	SO_EXT:0000704	denotes	gene
T3989	10896-10901	NCBITaxon:9606	denotes	Human
T3990	10902-10907	PR_EXT:000001856	denotes	RHAMM
T3991	10916-10926	GO_SO_EXT:chromosome	denotes	chromosome
T3992	10955-10959	PR_EXT:000008212	denotes	GPX3
T3993	10964-10969	PR_EXT:000011245	denotes	NKX2E
T3994	11007-11012	SO_EXT:0000704	denotes	genes
T3995	11016-11021	NCBITaxon:9606	denotes	human
T3996	11022-11032	GO_SO_EXT:chromosome	denotes	chromosome
T3997	11044-11054	SO:0000859	denotes	paralogous
T3998	11127-11138	GO_SO_EXT:chromosome	denotes	chromosomes
T3999	11142-11147	NCBITaxon:10088	denotes	mouse
T4000	11152-11155	NCBITaxon:10114	denotes	rat
T4001	11206-11211	SO_EXT:0000704	denotes	genes
T4002	11216-11226	GO_SO_EXT:sequence_transposition_process	denotes	transposed
T4003	11254-11261	NCBITaxon:9443	denotes	primate
T4004	11262-11268	NCBITaxon:9989	denotes	rodent
T4006	11979-11983	SO_EXT:0000704	denotes	gene
T4007	12033-12037	SO_EXT:0000704	denotes	gene
T4008	12038-12048	GO:0065007	denotes	regulation
T4009	12100-12119	SO_EXT:0000854	denotes	paralogous segments
T4010	12137-12143	SO_EXT:0001026	denotes	genome
T4011	12151-12159	NCBITaxon:7712	denotes	tunicate
T4012	12160-12175	NCBITaxon:7719	denotes	C. intestinalis
T4013	12214-12224	NCBITaxon:7742	denotes	vertebrate
T4014	12225-12231	SO_EXT:0001026	denotes	genome
T4015	12251-12262	NCBITaxon:31033	denotes	T. rubripes
T4016	12318-12324	SO_EXT:0001026	denotes	genome
T4017	12328-12339	NCBITaxon:31033	denotes	T. rubripes
T4018	12366-12386	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T4019	12387-12397	SO:0000859	denotes	paralogous
T4020	12423-12434	NCBITaxon:7742	denotes	vertebrates
T4021	12463-12474	SO_EXT:0000855	denotes	orthologues
T4022	12478-12484	PR_EXT:000008258	denotes	GPRK2L
T4023	12489-12494	PR_EXT:000013947	denotes	RGS12
T4024	12508-12519	NCBITaxon:31033	denotes	T. rubripes
T4025	12520-12528	SO_EXT:0001248	denotes	scaffold
T4026	12571-12572	CHEBI_SO_EXT:base	denotes	b
T4027	12590-12595	NCBITaxon:9606	denotes	human
T4028	12606-12617	NCBITaxon:31033	denotes	T. rubripes
T4029	12618-12629	SO_EXT:0000855	denotes	orthologues
T4030	12633-12638	PR_EXT:000001450	denotes	FGFR3
T4031	12685-12686	CHEBI_SO_EXT:base	denotes	b
T4032	12687-12694	SO_EXT:0001026	denotes	genomic
T4033	12695-12703	SO_EXT:0001248	denotes	scaffold
T4034	12755-12760	NCBITaxon:9606	denotes	human
T4035	12761-12772	SO_EXT:0000855	denotes	orthologues
T4036	12782-12787	SO_EXT:0000704	denotes	genes
T4037	12817-12818	CHEBI_SO_EXT:base	denotes	b
T4038	12855-12860	PR_EXT:000016008	denotes	TACC3
T4039	12865-12870	PR_EXT:000007506	denotes	FGFRL
T4040	12894-12903	SO_EXT:0001248	denotes	scaffolds
T4041	12963-12967	SO_EXT:0000704	denotes	gene
T4042	13002-13007	PR_EXT:000008260	denotes	GPRK6
T4043	13011-13016	NCBITaxon:9606	denotes	human
T4044	13017-13027	GO_SO_EXT:chromosome	denotes	chromosome
T4045	13059-13069	NCBITaxon:31031	denotes	pufferfish
T4046	13080-13091	NCBITaxon:31033	denotes	T. rubripes
T4047	13092-13103	SO_EXT:0000855	denotes	orthologues
T4048	13107-13111	PR_EXT:000011441	denotes	NSD1
T4049	13113-13118	PR_EXT:000001451	denotes	FGFR4
T4050	13134-13138	SO_EXT:0000704	denotes	gene
T4051	13150-13158	SO_EXT:0001248	denotes	scaffold
T4052	13219-13223	SO_EXT:0000704	denotes	gene
T4053	13249-13253	SO_EXT:0000704	denotes	gene
T4054	13330-13339	SO_EXT:biological_sequence	denotes	sequences
T4055	13368-13373	PR_EXT:000016006	denotes	TACC1
T4056	13382-13387	SO_EXT:0000704	denotes	genes
T4057	13395-13405	NCBITaxon:31031	denotes	pufferfish
T4058	13439-13440	CHEBI_SO_EXT:base	denotes	b
T4059	13441-13449	SO_EXT:0001248	denotes	scaffold
T4060	13500-13511	SO_EXT:0000855	denotes	orthologues
T4061	13523-13528	SO_EXT:0000704	denotes	genes
T4062	13540-13545	NCBITaxon:9606	denotes	human
T4063	13546-13556	GO_SO_EXT:chromosome	denotes	chromosome
T4064	13577-13585	SO_EXT:0001248	denotes	scaffold
T4065	13618-13623	PR_EXT:000016006	denotes	TACC1
T4066	13624-13643	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T4067	13670-13681	NCBITaxon:7742	denotes	vertebrates
T4068	13715-13719	SO_EXT:0000704	denotes	gene
T4069	13743-13744	CHEBI_SO_EXT:base	denotes	b
T4070	13745-13753	SO_EXT:0001248	denotes	scaffold
T4071	13782-13790	SO_EXT:0001248	denotes	scaffold
T4072	13809-13820	NCBITaxon:31033	denotes	T. rubripes
T4073	13821-13832	SO_EXT:0000855	denotes	orthologues
T4074	13836-13840	PR_EXT:000010686	denotes	MSX1
T4075	13842-13847	PR_EXT:000015790	denotes	STX18
T4076	13865-13879	SO_EXT:0000996	denotes	predicted gene
T4077	13906-13915	SO_EXT:biological_sequence	denotes	sequences
T4078	13921-13929	SO:0000857	denotes	homology
T4079	13933-13937	PR_EXT:000009884	denotes	LOXL
T4080	13939-13942	PR_EXT:000007232	denotes	EVC
T4081	13981-13989	SO_EXT:0001248	denotes	scaffold
T4082	14002-14007	SO_EXT:0000704	denotes	genes
T4083	14021-14031	_FRAGMENT	denotes	regions of
T4084	14038-14048	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosome
T4085	14032-14037	NCBITaxon:9606	denotes	human
T4086	14089-14094	PR_EXT:000016008	denotes	TACC3
T4087	14099-14104	PR_EXT:000016007	denotes	TACC2
T4088	14164-14171	SO_EXT:0001026	denotes	genomic
T4089	14212-14223	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T4119	15003-15008	PR_EXT:000001856	denotes	RHAMM
T4120	15009-15014	SO_EXT:0000704	denotes	genes
T4121	15018-15033	NCBITaxon:7719	denotes	C. intestinalis
T4122	15084-15103	SO_EXT:0000854	denotes	paralogous segments
T4123	15121-15125	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T4124	15131-15136	SO_EXT:0000704	denotes	genes
T4125	15217-15230	GO_SO_EXT:sequence_rearrangement_entity_or_process	denotes	rearrangement
T4126	15234-15243	NCBITaxon:7712	denotes	tunicates
T4127	15288-15299	NCBITaxon:31033	denotes	T. rubripes
T4128	15300-15306	SO_EXT:0001026	denotes	genome
T4129	15379-15390	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T4130	15398-15417	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T4131	15437-15442	PR_EXT:000001450	denotes	FGFR3
T4132	15477-15481	SO_EXT:0000704	denotes	gene
T4133	15498-15502	SO_EXT:0000704	denotes	gene
T4134	15526-15536	NCBITaxon:7742	denotes	vertebrate
T4135	15579-15591	NCBITaxon:61463	denotes	Gnanthostome
T4136	15666-15684	SO_EXT:0000854	denotes	paralogous segment
T4137	15718-15727	NCBITaxon:7737	denotes	amphioxus
T4138	15732-15739	NCBITaxon:7745	denotes	lamprey
T4139	15740-15747	SO_EXT:0001026	denotes	genomes
T4140	15769-15773	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T4141	15774-15778	SO_EXT:0000704	denotes	gene
T4142	15818-15822	SO_EXT:sequence_copy_entity	denotes	copy
T4143	15850-15855	SO_EXT:0000704	denotes	genes
T4144	15864-15873	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T5361	17053-17060	SO_EXT:0001026	denotes	genomic
T5362	17094-17105	SO_EXT:genomic_DNA	denotes	genomic DNA
T5363	17102-17105	CHEBI_SO_EXT:DNA	denotes	DNA
T5364	17106-17115	SO_EXT:biological_sequence	denotes	sequences
T5365	17137-17148	SO:0000858	denotes	orthologous
T5366	17154-17159	SO_EXT:0000704	denotes	genes
T5367	17163-17168	NCBITaxon:9606	denotes	human
T5368	17170-17175	NCBITaxon:10088	denotes	mouse
T5369	17177-17180	NCBITaxon:10114	denotes	rat
T5370	17182-17192	NCBITaxon:31031	denotes	pufferfish
T5371	17194-17209	NCBITaxon:7719	denotes	C. intestinalis
T5372	17211-17226	NCBITaxon:7227	denotes	D. melanogaster
T5373	17231-17241	NCBITaxon:6239	denotes	C. elegans
T5374	17309-17316	SO_EXT:0001026	denotes	genomic
T5375	17340-17344	SO_EXT:0000704	denotes	gene
T5376	17365-17368	NCBITaxon:10114	denotes	rat
T5377	17373-17383	NCBITaxon:31031	denotes	pufferfish
T5378	17385-17390	SO_EXT:0000147	denotes	exons
T5379	17405-17413	SO_EXT:sequence_alteration_process	denotes	modified
T5380	17446-17456	GO:0006412	denotes	translated
T5381	17457-17465	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptides
T5382	17487-17492	NCBITaxon:10088	denotes	mouse
T5383	17497-17502	NCBITaxon:9606	denotes	human
T5384	17503-17511	CHEBI_PR_EXT:protein	denotes	proteins
T5385	17534-17542	SO_EXT:biological_sequence	denotes	sequence
T5386	17557-17568	NCBITaxon:31033	denotes	T. rubripes
T5387	17570-17577	SO_EXT:0001026	denotes	genomic
T5388	17578-17587	SO_EXT:biological_sequence	denotes	sequences
T5389	17604-17609	CHEBI:15377	denotes	water
T5390	17610-17620	NCBITaxon:31031	denotes	pufferfish
T5391	17622-17644	NCBITaxon:99883	denotes	Tetraodon nigroviridis
T5392	17699-17704	SO_EXT:0000147	denotes	exons
T5393	17740-17745	SO_EXT:0000704	denotes	genes
T5394	17750-17758	CHEBI_PR_EXT:protein	denotes	proteins
T5395	17791-17800	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T5396	17838-17844	SO_EXT:0000417	denotes	domain
T5397	17864-17880	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	carboxy terminus
T5398	17888-17895	CHEBI_PR_EXT:protein	denotes	protein
T5399	17916-17926	NCBITaxon:6239	denotes	C. elegans
T5400	17931-17938	CHEBI_PR_EXT:protein	denotes	protein
T5401	17985-17992	CHEBI_PR_EXT:protein	denotes	protein
T5402	18000-18007	SO_EXT:sequence_coding_function	denotes	encoded
T5403	18028-18033	SO_EXT:0000147	denotes	exons
T5404	18041-18045	SO_EXT:0000704	denotes	gene
T5405	18061-18070	NCBITaxon:1	denotes	organisms
T5406	18072-18087	NCBITaxon:7227	denotes	D. melanogaster
T5407	18097-18110	NCBITaxon:33511	denotes	deuterostomes
T5408	18111-18126	NCBITaxon:7719	denotes	C. intestinalis
T5409	18130-18135	NCBITaxon:9606	denotes	human
T5410	18158-18165	SO_EXT:sequence_coding_function	denotes	encoded
T5411	18179-18184	SO_EXT:0000147	denotes	exons
T5412	18192-18196	SO_EXT:0000704	denotes	gene
T5413	18206-18221	NCBITaxon:7227	denotes	D. melanogaster
T5414	18236-18248	NCBITaxon:33511	denotes	deuterostome
T5415	18249-18254	SO_EXT:0000704	denotes	genes
T5416	18277-18283	SO_EXT:0000417	denotes	domain
T5417	18337-18345	SO:0000857	denotes	homology
T5418	18380-18384	SO_EXT:0000704	denotes	gene
T5419	18404-18408	SO_EXT:0000147	denotes	exon
T5420	18460-18471	SO_EXT:0000855	denotes	orthologues
T5421	18521-18526	PR_EXT:000016008	denotes	TACC3
T5422	18527-18532	SO_EXT:0000704	denotes	genes
T5423	18540-18551	NCBITaxon:7742	denotes	vertebrates
T5424	18568-18581	NCBITaxon:33511	denotes	deuterostomes
T5425	18588-18592	SO_EXT:0000147	denotes	exon
T5426	18610-18616	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T5427	18640-18646	NCBITaxon:39107	denotes	murine
T5428	18647-18654	PR_EXT:000016008	denotes	TACC3's
T5429	18658-18664	NCBITaxon:9989	denotes	rodent
T5430	18677-18687	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T5431	18688-18694	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T5432	18726-18733	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T5433	18741-18777	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T5434	18749-18769	GO:0006338	denotes	chromatin remodeling
T5435	18788-18793	PR_EXT:000017527	denotes	GAS41
T5436	18810-18820	NCBITaxon:7742	denotes	vertebrate
T5437	18826-18834	CHEBI_PR_EXT:protein	denotes	proteins
T5438	18840-18845	PR_EXT:000016008	denotes	TACC3
T5439	18846-18857	SO_EXT:0000855	denotes	orthologues
T5440	18900-18908	SO_EXT:biological_sequence	denotes	sequence
T5441	18935-18946	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T5442	18955-18958	NCBITaxon:10114	denotes	rat
T5443	18959-18964	PR_EXT:000016008	denotes	TACC3
T5444	18965-18972	CHEBI_PR_EXT:protein	denotes	protein
T5445	18981-18992	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T5446	19000-19011	NCBITaxon:7955	denotes	Danio rerio
T5447	19012-19019	CHEBI_PR_EXT:protein	denotes	protein
T5448	19077-19084	SO_EXT:0001026	denotes	genomic
T5449	19102-19107	PR_EXT:000016008	denotes	TACC3
T5450	19108-19119	SO_EXT:0000855	denotes	orthologues
T5451	19121-19126	PR_EXT:000016008	denotes	TACC3
T5452	19165-19174	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T5453	19175-19185	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T5454	19207-19218	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T5455	19220-19227	SO_EXT:sequence_coding_function	denotes	encoded
T5456	19231-19236	SO_EXT:0000147	denotes	exons
T5457	19253-19263	NCBITaxon:7742	denotes	vertebrate
T5458	19264-19269	PR_EXT:000016008	denotes	TACC3
T5459	19270-19274	SO_EXT:0000704	denotes	gene
T5460	19280-19289	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T5461	19295-19301	SO_EXT:0000417	denotes	domain
T5462	19335-19340	SO_EXT:0000147	denotes	exons
T5463	19392-19404	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T5464	19422-19430	SO_EXT:biological_sequence	denotes	sequence
T5465	19461-19466	PR_EXT:000016008	denotes	TACC3
T5466	19467-19475	CHEBI_PR_EXT:protein	denotes	proteins
T5467	19479-19484	NCBITaxon:9606	denotes	human
T5468	19489-19494	NCBITaxon:10088	denotes	mouse
T5469	19578-19589	SO_EXT:0000855	denotes	orthologues
T5470	19656-19662	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T5471	19663-19669	SO_EXT:sequence_or_structure_motif	denotes	motifs
T5472	19674-19681	SO_EXT:sequence_coding_function	denotes	encoded
T5473	19689-19693	SO_EXT:0000147	denotes	exon
T5474	19697-19702	NCBITaxon:9606	denotes	human
T5475	19711-19721	NCBITaxon:31031	denotes	pufferfish
T5476	19745-19752	NCBITaxon:9989	denotes	rodents
T5477	19815-19825	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T5478	19826-19833	SO_EXT:sequence_repeat_unit_or_region	denotes	repeats
T5479	19865-19869	SO_EXT:0000147	denotes	exon
T5480	19877-19882	NCBITaxon:10088	denotes	mouse
T5481	19887-19890	NCBITaxon:10114	denotes	rat
T5482	19891-19896	PR_EXT:000016008	denotes	TACC3
T5483	19897-19902	SO_EXT:0000704	denotes	genes
T5484	19956-19961	NCBITaxon:10088	denotes	mouse
T5485	19962-19967	PR_EXT:000016008	denotes	TACC3
T5486	19968-19974	GO:0008380	denotes	splice
T5487	19968-19983	SO_EXT:alternative_splice_variant	denotes	splice variants
T5488	20019-20026	SO_EXT:sequence_repeat_unit_or_region	denotes	repeats
T5489	20046-20053	SO_EXT:sequence_repeat_unit_or_region	denotes	repeats
T5490	20078-20082	SO_EXT:0000147	denotes	exon
T5491	20123-20132	SO_EXT:biological_sequence	denotes	sequences
T5492	20158-20161	CHEBI_SO_EXT:DNA	denotes	DNA
T5493	20158-20173	GO_EXT:0034061	denotes	DNA polymerases
T5494	20186-20190	SO_EXT:cDNA	denotes	cDNA
T5495	20244-20250	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T5496	20251-20256	SO_EXT:sequence_or_structure_motif	denotes	motif
T5497	20270-20278	SO_EXT:biological_sequence	denotes	sequence
T5498	20375-20382	SO_EXT:sequence_repeat_unit_or_region	denotes	repeats
T5499	20406-20412	NCBITaxon:9986	denotes	rabbit
T5500	20413-20420	CHEBI_PR_EXT:protein	denotes	protein
T5501	20440-20447	CHEBI_PR_EXT:protein	denotes	protein
T5502	20475-20481	NCBITaxon:9989	denotes	rodent
T5503	20482-20487	PR_EXT:000016008	denotes	TACC3
T5504	20554-20563	NCBITaxon:8292	denotes	amphibian
T5505	20564-20571	NCBITaxon:8353	denotes	Xenopus
T5506	20572-20577	PR_EXT:000016008	denotes	TACC3
T6303	20592-20612	GO:0000380	denotes	Alternative splicing
T6304	20616-20626	NCBITaxon:7742	denotes	vertebrate
T6305	20632-20637	SO_EXT:0000704	denotes	genes
T6306	20646-20650	SO_EXT:0000147	denotes	exon
T6307	20705-20709	SO_EXT:0000704	denotes	gene
T6308	20763-20769	UBERON:0000479	denotes	tissue
T6309	20779-20799	GO:0000380	denotes	alternative splicing
T6310	20805-20809	SO_EXT:0000704	denotes	gene
T6311	20866-20870	SO_EXT:0000704	denotes	gene
T6312	20882-20896	_FRAGMENT	denotes	development of
T6313	20900-20908	GO:0044767	denotes	organism
T6314	20900-20908	NCBITaxon:1	denotes	organism
T6315	20922-20942	GO:0000380	denotes	alternative splicing
T6316	20946-20951	PR_EXT:000016008	denotes	TACC3
T6317	20999-21005	UBERON:0000479	denotes	tissue
T6318	21015-21023	GO:0008380	denotes	splicing
T6319	21043-21048	PR_EXT:000016006	denotes	TACC1
T6320	21053-21058	PR_EXT:000016007	denotes	TACC2
T6321	21059-21064	SO_EXT:0000704	denotes	genes
T6322	21081-21086	PR_EXT:000016007	denotes	TACC2
T6323	21112-21113	CHEBI_SO_EXT:base	denotes	b
T6324	21115-21119	SO_EXT:0000147	denotes	exon
T6325	21171-21177	GO:0008380	denotes	splice
T6326	21171-21186	SO_EXT:alternative_splice_variant	denotes	splice variants
T6327	21194-21204	NCBITaxon:7742	denotes	vertebrate
T6328	21205-21210	PR_EXT:000016007	denotes	TACC2
T6329	21211-21216	SO_EXT:0000704	denotes	genes
T6330	21226-21246	GO:0000380	denotes	alternative splicing
T6331	21255-21259	SO_EXT:0000147	denotes	exon
T6332	21315-21320	PR_EXT:000016007	denotes	TACC2
T6333	21321-21329	SO_EXT:0001060	denotes	isoforms
T6334	21398-21403	PR_EXT:000016007	denotes	TACC2
T6335	21442-21447	PR_EXT:000016006	denotes	TACC1
T6336	21500-21507	SO_EXT:0001060	denotes	isoform
T6337	21528-21548	GO:0000380	denotes	Alternative splicing
T6338	21577-21585	SO_EXT:0000167	denotes	promoter
T6339	21623-21628	NCBITaxon:9606	denotes	human
T6340	21629-21634	PR_EXT:000016006	denotes	TACC1
T6341	21635-21639	SO_EXT:0000704	denotes	gene
T6342	21712-21717	PR_EXT:000016006	denotes	TACC1
T6343	21718-21726	SO_EXT:0001060	denotes	isoforms
T6344	21744-21764	GO:0000380	denotes	alternative splicing
T6345	21768-21773	SO_EXT:0000147	denotes	exons
T6346	21814-21822	SO_EXT:0001060	denotes	isoforms
T6347	21855-21862	SO_EXT:sequence_deletion_process	denotes	deleted
T6348	21880-21888	SO_EXT:sequence_variant_entity	denotes	variants
T6349	21905-21912	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T6350	21905-21917	SO_EXT:0000409	denotes	binding site
T6351	21922-21926	PR_EXT:000009965	denotes	LSm7
T6352	21933-21941	SO_EXT:sequence_variant_entity	denotes	variants
T6353	21965-21972	GO:0005634	denotes	nuclear
T6354	21965-21993	SO_EXT:0001528	denotes	nuclear localization signals
T6355	21973-21985	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T6356	21998-22005	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T6357	21998-22010	SO_EXT:0000409	denotes	binding site
T6358	22015-22020	PR_EXT:000017527	denotes	GAS41
T6359	22030-22040	PR_EXT:000029784	denotes	PCTAIRE2BP
T6360	22047-22055	SO_EXT:0001060	denotes	isoforms
T6361	22078-22086	SO_EXT:0001060	denotes	isoforms
T6362	22098-22107	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T6363	22127-22136	GO:0005737	denotes	cytoplasm
T6364	22171-22179	SO_EXT:0001060	denotes	isoforms
T6365	22231-22239	GO:0000785	denotes	chomatin
T6366	22231-22250	GO:0006338	denotes	chomatin remodeling
T6367	22258-22261	CHEBI_SO_EXT:RNA	denotes	RNA
T6368	22258-22272	GO:0006396	denotes	RNA processing
T6369	22262-22272	SO_EXT:sequence_alteration_process	denotes	processing
T6370	22290-22297	GO:0005634	denotes	nucleus
T6371	22334-22339	PR_EXT:000016006	denotes	TACC1
T6372	22340-22348	SO_EXT:0001060	denotes	isoforms
T6373	22356-22360	CL_GO_EXT:cell	denotes	cell
T6374	22390-22398	CL_GO_EXT:cell	denotes	cellular
T6375	22390-22398	_FRAGMENT	denotes	cellular
T6376	22403-22413	GO:0044237	denotes	metabolism
T6377	22399-22402	CHEBI_SO_EXT:RNA	denotes	RNA
T6378	22399-22413	GO:0016070	denotes	RNA metabolism
T6379	22493-22501	SO_EXT:0001060	denotes	isoforms
T6380	22545-22559	UBERON:0001199	denotes	gastric mucosa
T7014	23812-23819	CHEBI_PR_EXT:protein	denotes	protein
T7015	23833-23840	CHEBI_PR_EXT:protein	denotes	protein
T7016	23845-23852	SO_EXT:0001026	denotes	genomic
T7017	23951-23958	CHEBI_PR_EXT:protein	denotes	protein
T7018	24011-24020	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T7019	24026-24032	SO_EXT:0000417	denotes	domain
T7020	24053-24060	CHEBI_PR_EXT:protein	denotes	protein
T7021	24061-24068	CHEBI_PR_EXT:protein	denotes	protein
T7022	24104-24111	GO:0007067	denotes	mitotic
T7023	24104-24119	GO:0072686	denotes	mitotic spindle
T7024	24124-24135	GO:0005813	denotes	centrosomal
T7025	24227-24236	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T7026	24263-24272	SO_EXT:0000853	denotes	homologue
T7027	24276-24281	NCBITaxon_EXT:yeast	denotes	yeast
T7028	24283-24289	PR_EXT:P39723	denotes	spc-72
T7029	24307-24312	NCBITaxon:9606	denotes	human
T7030	24318-24326	CHEBI_PR_EXT:protein	denotes	proteins
T7031	24369-24377	CHEBI_PR_EXT:protein	denotes	proteins
T7032	24418-24424	SO_EXT:0000417	denotes	domain
T7033	24435-24446	GO:0005874	denotes	microtubule
T7034	24447-24458	GO:0005813	denotes	centrosomal
T7035	24459-24467	CHEBI_PR_EXT:protein	denotes	proteins
T7036	24475-24479	PR_EXT:P46675	denotes	stu2
T7037	24480-24484	PR_EXT:Q9VEZ3	denotes	msps
T7038	24485-24491	PR_EXT:000005512	denotes	ch-TOG
T7039	24525-24539	PR_EXT:000035365	denotes	Aurora kinases
T7040	24532-24539	GO_EXT:0016301	denotes	kinases
T7041	24620-24625	PR_EXT:P39723	denotes	spc72
T7042	24638-24643	PR_EXT:000016008	denotes	TACC3
T7043	24644-24652	CHEBI_PR_EXT:protein	denotes	proteins
T7044	24660-24670	GO:0005813	denotes	centrosome
T7045	24728-24738	GO:0005813	denotes	centrosome
T7046	24743-24750	GO:0007067	denotes	mitotic
T7047	24743-24758	GO:0072686	denotes	mitotic spindle
T7048	24795-24804	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T7049	24867-24872	NCBITaxon:9606	denotes	human
T7050	24878-24886	CHEBI_PR_EXT:protein	denotes	proteins
T7051	24937-24951	PR_EXT:000035365	denotes	Aurora kinases
T7052	24944-24951	GO_EXT:0016301	denotes	kinases
T7053	24967-24972	PR_EXT:000016006	denotes	TACC1
T7054	24977-24982	PR_EXT:000016008	denotes	TACC3
T7055	24997-25012	PR_EXT:000004515	denotes	Aurora A kinase
T7056	25006-25012	GO_EXT:0016301	denotes	kinase
T7057	25022-25027	PR_EXT:000016007	denotes	TACC2
T7058	25043-25058	PR_EXT:000004518	denotes	Aurora C kinase
T7059	25052-25058	GO_EXT:0016301	denotes	kinase
T7060	25150-25158	NCBITaxon:7711	denotes	chordate
T7061	25192-25202	NCBITaxon:7742	denotes	vertebrate
T7062	25208-25213	SO_EXT:0000704	denotes	genes
T7063	25219-25231	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T7064	25239-25249	NCBITaxon:7742	denotes	vertebrate
T7065	25255-25263	CHEBI_PR_EXT:protein	denotes	proteins
T7066	25271-25281	GO:0051325	denotes	interphase
T7067	25282-25289	GO:0005634	denotes	nucleus
T7068	25380-25390	GO:0005813	denotes	centrosome
T7069	25395-25406	GO:0005874	denotes	microtubule
T7070	25395-25415	GO:0000226	denotes	microtubule dynamics
T7071	25467-25478	NCBITaxon:33317	denotes	protostomes
T7072	25483-25496	NCBITaxon:33511	denotes	deuterostomes
T7073	25555-25560	SO_EXT:0000704	denotes	genes
T7074	25581-25586	SO_EXT:0000147	denotes	exons
T7075	25647-25657	NCBITaxon:6239	denotes	C. elegans
T7107	26210-26216	PR_EXT:Q965W2	denotes	nhr-86
T7108	26287-26297	NCBITaxon:7215	denotes	Drosophila
T7109	26322-26330	CHEBI_PR_EXT:protein	denotes	proteins
T7110	26336-26339	CHEBI_SO_EXT:RNA	denotes	RNA
T7111	26340-26347	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T7112	26348-26355	CHEBI_PR_EXT:protein	denotes	protein
T7113	26413-26423	NCBITaxon:7215	denotes	Drosophila
T7114	26424-26460	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T7115	26432-26452	GO:0006338	denotes	chromatin remodeling
T7116	26465-26468	CHEBI_SO_EXT:DNA	denotes	DNA
T7117	26465-26482	GO:0006281	denotes	DNA damage repair
T7118	26519-26526	CHEBI_PR_EXT:protein	denotes	protein
T7119	26564-26567	CHEBI_SO_EXT:DNA	denotes	DNA
T7120	26564-26574	GO:0006281	denotes	DNA repair
T7121	26615-26625	NCBITaxon:6239	denotes	C. elegans
T7122	26626-26631	PR_EXT:000004642	denotes	BARD1
T7123	26632-26642	SO_EXT:0000855	denotes	orthologue
T7124	26712-26720	CHEBI_PR_EXT:protein	denotes	proteins
T7125	26732-26741	NCBITaxon:1	denotes	organisms
T7126	26864-26871	GO_EXT:0016301	denotes	kinases
T7127	26880-26884	PR_EXT:P46675	denotes	stu2
T7128	26885-26889	PR_EXT:Q9VEZ3	denotes	msps
T7129	26890-26896	PR_EXT:000005512	denotes	ch-TOG
T7130	28029-28054	SO_EXT:biological_conservation_process_or_quality	denotes	evolutionary conservation
T7131	28067-28073	SO_EXT:0000417	denotes	domain
T7132	28141-28151	NCBITaxon:6239	denotes	C. elegans
T7133	28156-28171	NCBITaxon:7227	denotes	D. melanogaster
T7134	28200-28207	NCBITaxon:33208	denotes	animals
T7135	28316-28326	NCBITaxon:7742	denotes	vertebrate
T7136	28376-28386	NCBITaxon:6239	denotes	C. elegans
T7137	28396-28404	CHEBI_PR_EXT:protein	denotes	proteins
T7138	28405-28411	PR_EXT:Q27365	denotes	lin15A
T7139	28413-28418	PR_EXT:P34427	denotes	lin36
T7140	28423-28428	PR_EXT:000009822	denotes	lin37
T7141	28461-28471	SO_EXT:0000853	denotes	homologues
T7142	28475-28486	NCBITaxon:7742	denotes	vertebrates
T7143	28490-28500	NCBITaxon:7215	denotes	Drosophila
T7144	28529-28533	CHEBI_EXT:zinc	denotes	zinc
T7145	28541-28547	SO_EXT:0000417	denotes	domain
T7146	28551-28556	PR_EXT:P34427	denotes	lin36
T7147	28579-28586	CHEBI_PR_EXT:protein	denotes	protein
T7148	28611-28624	GO_EXT:transcription	denotes	transcription
T7149	28639-28646	GO_EXT:0060090	denotes	adaptor
T7150	28678-28686	CHEBI_PR_EXT:protein	denotes	proteins
T7151	28714-28722	CHEBI_PR_EXT:protein	denotes	proteins
T7152	28744-28749	PR_EXT:000016057	denotes	TDP43
T7153	28753-28760	CHEBI_PR_EXT:protein	denotes	protein
T7154	28775-28790	GO_EXT:transcription	denotes	transcriptional
T7155	28791-28801	GO:0065007	denotes	regulation
T7156	28806-28814	GO:0008380	denotes	splicing
T7157	28855-28860	NCBITaxon:9606	denotes	human
T7158	28861-28870	SO_EXT:0000853	denotes	homologue
T7159	28929-28934	NCBITaxon:9606	denotes	human
T7160	28962-28971	CHEBI_SO_EXT:glutamine	denotes	glutamine
T7161	28977-28990	GO_EXT:transcription	denotes	transcription
T7162	28977-28998	GO_EXT:transcription_factor	denotes	transcription factors
T7163	29007-29011	PR_EXT:CREB	denotes	CREB
T7164	29020-29021	CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	G
T7165	29020-29025	SO_EXT:0001980	denotes	G-box
T7166	29026-29033	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T8188	29113-29123	NCBITaxon:7742	denotes	vertebrate
T8189	29129-29137	CHEBI_PR_EXT:protein	denotes	proteins
T8190	29167-29177	NCBITaxon:7742	denotes	vertebrate
T8191	29364-29374	NCBITaxon:7742	denotes	vertebrate
T8192	29395-29403	CHEBI_PR_EXT:protein	denotes	proteins
T8193	29454-29462	CHEBI_PR_EXT:protein	denotes	proteins
T8194	29477-29487	GO:0005813	denotes	centrosome
T8195	29488-29495	GO:0007067	denotes	mitotic
T8196	29488-29503	GO:0072686	denotes	mitotic spindle
T8197	29521-29529	CHEBI_PR_EXT:protein	denotes	proteins
T8198	29542-29546	SO_EXT:0000704	denotes	gene
T8199	29547-29557	GO:0065007	denotes	regulation
T8200	29582-29595	GO_EXT:transcription	denotes	transcription
T8201	29611-29614	CHEBI_SO_EXT:RNA	denotes	RNA
T8202	29611-29625	GO:0006396	denotes	RNA processing
T8203	29615-29625	SO_EXT:sequence_alteration_process	denotes	processing
T8204	29630-29641	GO:0006412	denotes	translation
T8205	29686-29694	CHEBI_PR_EXT:protein	denotes	proteins
T8206	29797-29804	CHEBI_PR_EXT:protein	denotes	protein
T8207	29797-29812	GO:0043234	denotes	protein complex
T8208	29889-29899	GO:0005813	denotes	centrosome
T8209	29920-29935	GO:0072686	denotes	mitotic spindle
T8210	29920-29944	GO:0090307	denotes	mitotic spindle assembly
T8211	29950-29955	NCBITaxon_EXT:yeast	denotes	yeast
T8212	30043-30053	NCBITaxon:7742	denotes	vertebrate
T8213	30054-30059	PR_EXT:000016008	denotes	TACC3
T8214	30060-30067	CHEBI_PR_EXT:protein	denotes	protein
T8215	30164-30171	GO:0007067	denotes	mitosis
T8216	30206-30221	PR_EXT:000004515	denotes	Aurora Kinase A
T8217	30213-30219	GO_EXT:0016301	denotes	Kinase
T8218	30263-30268	NCBITaxon:9606	denotes	human
T8219	30274-30281	CHEBI_PR_EXT:protein	denotes	protein
T8220	30282-30296	GO_PATO_EXT:phosphorylation_process_or_quality	denotes	phosphorylated
T8221	30305-30311	CHEBI_GO_SO_EXT:enzyme	denotes	enzyme
T8222	30358-30364	SO_EXT:0000417	denotes	domain
T8223	30372-30382	NCBITaxon:7742	denotes	vertebrate
T8224	30383-30394	SO_EXT:0000855	denotes	orthologues
T8225	30410-30415	PR_EXT:000016008	denotes	TACC3
T8226	30474-30481	NCBITaxon:species	denotes	species
T8227	30519-30528	NCBITaxon:8355	denotes	X. laevis
T8228	30541-30548	CHEBI_PR_EXT:protein	denotes	protein
T8229	30564-30571	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T8230	30564-30580	_FRAGMENT	denotes	binding site for
T8231	30591-30598	SO_EXT:0000410	denotes	protein
T8232	30585-30590	PR_EXT:000006990	denotes	eIF4E
T8233	30591-30598	CHEBI_PR_EXT:protein	denotes	protein
T8234	30639-30649	_FRAGMENT	denotes	control of
T8235	30670-30681	GO:0006417	denotes	translation
T8236	30650-30665	GO:0043631	denotes	polyadenylation
T8237	30689-30696	NCBITaxon:8353	denotes	Xenopus
T8238	30697-30703	CL:0000023	denotes	oocyte
T8239	30826-30836	NCBITaxon:7742	denotes	vertebrate
T8240	30837-30842	PR_EXT:000016008	denotes	TACC3
T8241	30843-30851	CHEBI_PR_EXT:protein	denotes	proteins
T8242	30870-30875	PR_EXT:000006990	denotes	eIF4E
T8243	30876-30880	PR_EXT:000005805	denotes	CPEB
T8244	30881-30888	GO:0032991	denotes	complex
T8245	30894-30899	NCBITaxon:9606	denotes	human
T8246	30907-30914	SO_EXT:0001060	denotes	isoform
T8247	30946-30951	PR_EXT:000006990	denotes	eIF4E
T8248	30952-30956	PR_EXT:000005805	denotes	CPEB
T8249	30957-30964	GO:0032991	denotes	complex
T8250	30980-30985	PR_EXT:000016006	denotes	TACC1
T8251	30986-30994	SO_EXT:0001060	denotes	isoforms
T8252	31086-31089	CHEBI_SO_EXT:RNA	denotes	RNA
T8253	31086-31098	GO:0008380	denotes	RNA splicing
T8254	31086-31089	_FRAGMENT	denotes	RNA
T8255	31103-31112	GO:0050658	denotes	transport
T8256	31188-31196	CHEBI_PR_EXT:protein	denotes	proteins
T8257	31223-31228	NCBITaxon_EXT:yeast	denotes	yeast
T8258	31269-31277	CHEBI_PR_EXT:protein	denotes	proteins
T8259	31283-31287	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T8260	31295-31300	NCBITaxon:9606	denotes	human
T8261	31306-31314	CHEBI_PR_EXT:protein	denotes	proteins
T8262	31357-31362	UBERON:0000955	denotes	brain
T8263	31427-31434	PR_EXT:000043452	denotes	histone
T8264	31427-31434	CHEBI:15358	denotes	histone
T8265	31427-31452	GO_EXT:0004402	denotes	histone acetyltransferase
T8266	31453-31460	PR_EXT:Q92830	denotes	hGCN5L2
T8267	31493-31500	SO_EXT:0001060	denotes	isoform
T8268	31504-31512	CHEBI:26537	denotes	retinoid
T8269	31504-31523	GO_EXT:0004886	denotes	retinoid-X receptor
T8270	31504-31525	PR_EXT:000014373	denotes	retinoid-X receptor β
T8271	31531-31538	CHEBI_PR_EXT:protein	denotes	protein
T8272	31568-31574	SO_EXT:0000417	denotes	domain
T8273	31578-31583	PR_EXT:000016007	denotes	TACC2
T8274	31647-31650	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T8275	31686-31690	PR_EXT:000014373	denotes	RXRβ
T8276	31725-31732	GO:0005634	denotes	nuclear
T8277	31733-31740	CHEBI_GO_EXT:hormone	denotes	hormone
T8278	31741-31749	GO_EXT:0004872	denotes	receptor
T8279	31751-31757	PR_EXT:Q965W2	denotes	nhr-86
T8280	31764-31774	NCBITaxon:6239	denotes	C. elegans
T8281	31807-31814	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T8282	31815-31822	CHEBI_PR_EXT:protein	denotes	protein
T8283	31823-31828	PR_EXT:P34427	denotes	lin36
T8284	31865-31875	NCBITaxon:33317	denotes	protostome
T8285	31905-31912	CHEBI_PR_EXT:protein	denotes	protein
T8286	31975-31984	NCBITaxon:1	denotes	organisms
T8287	32052-32060	CHEBI_PR_EXT:protein	denotes	proteins
T8288	32174-32181	SO_EXT:0000417	denotes	domains
T8289	32186-32197	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T8290	32205-32213	NCBITaxon:7711	denotes	chordate
T8291	32274-32284	NCBITaxon:7742	denotes	vertebrate
T8292	32290-32297	CHEBI_PR_EXT:protein	denotes	protein
T8293	32307-32322	GO_EXT:transcription	denotes	transcriptional
T8294	32307-32334	GO_EXT:0003713	denotes	transcriptional coactivator
T8295	32380-32384	PR_EXT:000004303	denotes	ARNT
T8296	32385-32398	GO_EXT:transcription	denotes	transcription
T8297	32385-32405	GO_EXT:transcription_factor	denotes	transcription factor
T8298	32442-32454	NCBITaxon:33511	denotes	deuterostome
T8299	32468-32474	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T8300	32490-32495	PR_EXT:000017527	denotes	GAS41
T8301	32533-32538	NCBITaxon:9606	denotes	human
T8302	32539-32575	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T8303	32547-32567	GO:0006338	denotes	chromatin remodeling
T8304	32604-32619	NCBITaxon:7227	denotes	D. melanogaster
T8305	32620-32629	SO_EXT:0000853	denotes	homologue
T8306	32633-32638	PR_EXT:000017527	denotes	GAS41
T8307	32797-32810	SO_EXT:0000657	denotes	repeat region
T8308	32818-32828	NCBITaxon:7215	denotes	Drosophila
T8309	32834-32841	CHEBI_PR_EXT:protein	denotes	protein
T8310	32874-32884	NCBITaxon:7742	denotes	vertebrate
T8311	32948-32963	GO_EXT:transcription	denotes	transcriptional
T8312	32964-32974	GO:0065007	denotes	regulatory
T8313	32975-32984	GO:0032991	denotes	complexes
T8314	32995-33003	GO:0030674	denotes	bridging
T8315	33004-33014	CHEBI_PR_EXT:protein	denotes	protein(s)
T8316	33061-33068	CHEBI_PR_EXT:protein	denotes	protein
T8317	33098-33104	SO_EXT:0000417	denotes	domain
T8318	33161-33172	NCBITaxon:33317	denotes	protostomes
T8319	33177-33190	NCBITaxon:33511	denotes	deuterostomes
T8320	33240-33248	GO:0030674	denotes	bridging
T8321	33249-33256	CHEBI_PR_EXT:protein	denotes	protein
T8322	33271-33277	PR_EXT:Q27365	denotes	lin15A
T8323	33279-33284	PR_EXT:P34427	denotes	lin36
T8324	33288-33293	PR_EXT:000009822	denotes	lin37
T8325	33333-33339	PR_EXT:Q27365	denotes	lin15A
T8326	33341-33346	PR_EXT:P34427	denotes	lin36
T8327	33351-33356	PR_EXT:000009822	denotes	lin37
T8328	33357-33367	SO_EXT:0000853	denotes	homologues
T8329	33378-33387	NCBITaxon:1	denotes	organisms
T8330	33471-33478	GO:0032991	denotes	complex
T8331	33510-33516	SO_EXT:0001026	denotes	genome
T12592	11488-11494	_FRAGMENT	denotes	region
T12593	11518-11531	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	on chromosome
T12594	11503-11507	PR_EXT:000008212	denotes	GPX3
T12595	11512-11517	PR_EXT:000011245	denotes	NKX2E
T12596	11521-11531	GO_SO_EXT:chromosome	denotes	chromosome
T12597	11586-11591	SO_EXT:0000704	denotes	genes
T12598	11592-11600	SO_EXT:sequence_insertion_process	denotes	inserted
T12599	11607-11618	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T12600	11653-11658	SO_EXT:0000704	denotes	genes
T12601	11694-11702	_FRAGMENT	denotes	syntenic
T12602	11721-11728	SO_EXT:0005858	denotes	regions
T12603	11703-11708	NCBITaxon:10088	denotes	mouse
T12604	11709-11728	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal regions
T12605	11750-11767	NCBITaxon:31033	denotes	Takifugu rubripes
T12606	11768-11777	SO_EXT:0001248	denotes	scaffolds
T12607	11821-11831	SO:0000857	denotes	homologous
T12608	11832-11836	SO_EXT:0000704	denotes	gene
T12609	11893-11903	SO:0000859	denotes	paralogous
T12610	11904-11909	SO_EXT:0000704	denotes	genes
T12784	15923-15940	NCBITaxon:31033	denotes	Takifugu rubripes
T12785	15945-15963	NCBITaxon:7719	denotes	Ciona intestinalis
T12786	15987-15994	SO_EXT:0001026	denotes	genomic
T12787	15995-16004	SO_EXT:0001248	denotes	scaffolds
T12788	16020-16037	NCBITaxon:31033	denotes	Takifugu rubripes
T12789	16060-16065	SO_EXT:0000704	denotes	genes
T12790	16067-16075	SO_EXT:0001248	denotes	Scaffold
T12791	16106-16110	SO_EXT:0000704	denotes	gene
T12792	16120-16125	SO_EXT:0000704	denotes	genes
T12793	16144-16154	SO_EXT:0000853	denotes	homologues
T12794	16158-16169	SO_EXT:0000855	denotes	orthologues
T12795	16189-16195	_FRAGMENT	denotes	arm of
T12796	16202-16212	SO_EXT:0000105	denotes	chromosome
T12797	16196-16201	NCBITaxon:9606	denotes	human
T12798	16202-16212	GO_SO_EXT:chromosome	denotes	chromosome
T12799	16231-16239	SO_EXT:0001248	denotes	scaffold
T12800	16327-16332	PR_EXT:000016006	denotes	TACC1
T12801	16333-16338	PR_EXT:000016007	denotes	TACC2
T12802	16339-16358	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T12803	16381-16389	SO_EXT:0001248	denotes	scaffold
T12804	16410-16421	SO_EXT:0000855	denotes	orthologues
T12805	16425-16430	SO_EXT:0000704	denotes	genes
T12806	16459-16465	_FRAGMENT	denotes	arm of
T12807	16472-16482	SO_EXT:0000105	denotes	chromosome
T12808	16466-16471	NCBITaxon:9606	denotes	human
T12809	16472-16482	GO_SO_EXT:chromosome	denotes	chromosome
T12810	16491-16509	NCBITaxon:7719	denotes	Ciona intestinalis
T12811	16530-16535	SO_EXT:0000704	denotes	genes
T12812	16545-16564	SO_EXT:0000854	denotes	paralogous segments
T12813	16568-16573	NCBITaxon:9606	denotes	human
T12970	16605-16612	SO_EXT:0001026	denotes	Genomic
T12971	16635-16640	SO_EXT:0000704	denotes	genes
T12972	16642-16651	SO_EXT:biological_conservation_process_or_quality	denotes	Conserved
T12973	16669-16673	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T12974	16674-16681	CHEBI_PR_EXT:protein	denotes	protein
T12975	16697-16702	NCBITaxon:9606	denotes	human
T12976	16708-16716	CHEBI_PR_EXT:protein	denotes	proteins
T12977	16736-16742	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T12978	16746-16751	NCBITaxon:9606	denotes	human
T12979	16752-16757	PR_EXT:000016006	denotes	TACC1
T12980	16772-16776	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T12981	16777-16782	PR_EXT:000017527	denotes	GAS41
T12982	16821-16827	SO_EXT:0000417	denotes	domain
T12983	16828-16833	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T12984	16834-16840	PR_EXT:000005512	denotes	ch-TOG
T12985	16860-16874	PR_EXT:000035365	denotes	Aurora kinases
T12986	16867-16874	GO_EXT:0016301	denotes	kinases
T12987	16882-16889	NCBITaxon:species	denotes	species
T12988	16913-16918	SO_EXT:sequence_or_structure_motif	denotes	motif
T12989	16941-16948	SO_EXT:sequence_coding_function	denotes	encoded
T12990	16959-16964	SO_EXT:0000147	denotes	exons
T12991	16977-16982	SO_EXT:0000704	denotes	genes
T12992	17008-17015	SO_EXT:0001060	denotes	isoform
T12993	17025-17029	SO_EXT:0000704	denotes	gene
T13160	22576-22596	GO:0000380	denotes	Alternative splicing
T13161	22604-22609	NCBITaxon:9606	denotes	human
T13162	22610-22615	PR_EXT:000016006	denotes	TACC1
T13163	22616-22620	SO_EXT:0000704	denotes	gene
T13164	22633-22639	GO:0008380	denotes	splice
T13165	22633-22648	SO_EXT:alternative_splice_variant	denotes	splice variants
T13166	22674-22679	NCBITaxon:9606	denotes	human
T13167	22680-22685	PR_EXT:000016006	denotes	TACC1
T13168	22734-22740	GO:0008380	denotes	splice
T13169	22734-22749	SO_EXT:alternative_splice_variant	denotes	splice variants
T13170	22783-22785	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	rt
T13171	22802-22807	NCBITaxon:9606	denotes	human
T13172	22808-22813	UBERON:0000955	denotes	brain
T13173	22814-22817	CHEBI_SO_EXT:RNA	denotes	RNA
T13174	22824-22844	GO:0000380	denotes	Alternative splicing
T13175	22848-22853	PR_EXT:000016006	denotes	TACC1
T13176	22861-22866	NCBITaxon:9606	denotes	human
T13177	22867-22872	UBERON:0000955	denotes	brain
T13178	22874-22876	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	rt
T13179	22899-22907	GO:0008380	denotes	splicing
T13180	22915-22932	SO_EXT:0000198	denotes	untranslated exon
T13181	22917-22927	GO:0006412	denotes	translated
T13182	22939-22943	SO_EXT:0000147	denotes	exon
T13183	22994-23004	CHEBI_SO_EXT:methionine	denotes	methionine
T13184	23021-23028	SO_EXT:sequence_variant_entity	denotes	Variant
T13185	23049-23053	SO_EXT:0000147	denotes	Exon
T13186	23062-23069	GO:0008380	denotes	splices
T13187	23073-23077	SO_EXT:0000147	denotes	exon
T13188	23094-23099	PR_EXT:000009965	denotes	L-Sm7
T13189	23100-23107	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T13190	23108-23113	SO_EXT:sequence_or_structure_motif	denotes	motif
T13191	23115-23122	SO_EXT:sequence_variant_entity	denotes	variant
T13192	23146-23154	SO_EXT:sequence_variant_entity	denotes	Variants
T13193	23173-23179	SO_EXT:sequence_deletion_process	denotes	delete
T13194	23180-23185	SO_EXT:0000147	denotes	exons
T13195	23206-23213	SO_EXT:sequence_variant_entity	denotes	variant
T13196	23252-23259	GO:0005634	denotes	nuclear
T13197	23252-23280	SO_EXT:0001528	denotes	nuclear localization signals
T13198	23260-23272	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T13199	23290-23297	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T13200	23298-23305	SO_EXT:0000417	denotes	domains
T13201	23310-23315	PR_EXT:000017527	denotes	GAS41
T13202	23320-23330	PR_EXT:000029784	denotes	PCTAIRE2BP
T13203	23338-23346	SO_EXT:sequence_variant_entity	denotes	variants
T13204	23369-23375	SO_EXT:0000417	denotes	domain
T13205	23408-23412	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T13206	23416-23422	PR_EXT:000005512	denotes	ch-TOG
T13207	23427-23442	PR_EXT:000004515	denotes	Aurora A kinase
T13208	23436-23442	GO_EXT:0016301	denotes	kinase
T13209	23450-23460	GO:0005813	denotes	centrosome
T13210	23751-23752	CHEBI_SO_EXT:base	denotes	b
T13586	26948-26956	CHEBI_PR_EXT:protein	denotes	proteins
T13587	26968-26978	NCBITaxon:6239	denotes	C. elegans
T13588	26983-26998	NCBITaxon:7227	denotes	D. melanogaster
T13589	27005-27015	NCBITaxon:6239	denotes	C. elegans
T13590	27178-27183	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T13591	27228-27237	GO:0000785	denotes	chromatin
T13592	27228-27248	GO:0006338	denotes	chromatin remodeling
T13593	27249-27258	GO:0032991	denotes	complexes
T13594	27260-27267	GO:0016514	denotes	SWI/SNF
T13595	27272-27279	PR_EXT:000043452	denotes	histone
T13596	27272-27279	CHEBI:15358	denotes	histone
T13597	27272-27298	GO_EXT:0004402	denotes	histone acetyltransferases
T13598	27301-27304	CHEBI_SO_EXT:DNA	denotes	DNA
T13599	27301-27318	GO:0006281	denotes	DNA damage repair
T13600	27334-27339	PR_EXT:RAD23	denotes	RAD23
T13601	27346-27349	CHEBI_SO_EXT:RNA	denotes	RNA
T13602	27346-27358	GO:0008380	denotes	RNA splicing
T13603	27346-27349	_FRAGMENT	denotes	RNA
T13604	27360-27369	GO:0050658	denotes	transport
T13605	27374-27387	GO:0006412	denotes	translational
T13606	27434-27444	NCBITaxon:7742	denotes	vertebrate
T13607	27512-27519	GO:0005634	denotes	nuclear
T13608	27520-27527	CHEBI_GO_EXT:hormone	denotes	hormone
T13609	27528-27536	GO_EXT:0004872	denotes	receptor
T13610	27537-27541	PR_EXT:000014373	denotes	RXRβ
T13611	27682-27701	SO_EXT:0000854	denotes	paralogous segments
T13612	27803-27813	NCBITaxon:7742	denotes	Vertebrate
T13613	27908-27918	NCBITaxon:7742	denotes	vertebrate
T13614	27919-27928	SO_EXT:0000853	denotes	homologue
T13615	27992-28005	PR_EXT:000035365	denotes	Aurora kinase
T13616	27999-28005	GO_EXT:0016301	denotes	kinase
T13860	33562-33568	PR_EXT:000016007	denotes	TACC2s
T13861	33603-33606	CHEBI:8984	denotes	SDS
T13862	33607-33621	CHEBI_EXT:polyacrylamide	denotes	polyacrylamide
T13863	33640-33650	GO:0006412	denotes	translated
T13864	33657-33666	SO_EXT:engineered_biological_sequence	denotes	construct
T13865	33684-33687	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T13866	33688-33693	PR_EXT:000016007	denotes	TACC2
T13867	33706-33709	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T13868	33749-33759	GO:0006412	denotes	translated
T13869	33760-33763	GO_EXT:0004886	denotes	RXR
T13870	33760-33765	PR_EXT:000014373	denotes	RXR-β
T13871	33766-33773	CHEBI_PR_EXT:protein	denotes	protein
T13872	33874-33877	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T13873	33878-33883	PR_EXT:000016007	denotes	TACC2
T13874	33888-33891	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T7077	25744-25749	NCBITaxon_EXT:yeast	denotes	Yeast
T12459	1413-1424	SO_EXT:0001080	denotes	coiled coil
T12460	1425-1433	CHEBI_PR_EXT:protein	denotes	proteins
T12461	1558-1569	SO_EXT:0001080	denotes	coiled coil
T12462	1581-1589	CHEBI_PR_EXT:protein	denotes	proteins
T12463	1611-1622	SO_EXT:0001080	denotes	coiled coil
T12464	1654-1659	PR_EXT:000001856	denotes	RHAMM
T12465	1692-1697	PR_EXT:000001856	denotes	RHAMM
T12466	1698-1706	CHEBI_PR_EXT:protein	denotes	proteins
T12467	1788-1796	CHEBI_PR_EXT:protein	denotes	proteins
T12468	1818-1826	CHEBI_PR_EXT:protein	denotes	proteins
T12584	11291-11297	SO:0000987	denotes	Linear
T12585	11314-11318	SO_EXT:0000704	denotes	gene
T12586	11347-11363	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal loci
T12587	11371-11375	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T12588	11376-11381	SO_EXT:0000704	denotes	genes
T12589	11385-11391	NCBITaxon:9606	denotes	humans
T12590	11393-11403	SO:0000859	denotes	Paralogous
T12591	11404-11409	SO_EXT:0000704	denotes	genes
T7076	25662-25677	NCBITaxon:7227	denotes	D. melanogaster
T7078	25800-25805	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T7079	25809-25819	NCBITaxon:6239	denotes	C. elegans
T7080	25809-25826	PR_EXT:Q27365	denotes	C. elegans lin15A
T7081	25809-25819	_FRAGMENT	denotes	C. elegans
T7082	25828-25833	PR_EXT:P34427	denotes	lin36
T7083	25838-25843	PR_EXT:000009822	denotes	lin37
T7084	25856-25864	CHEBI_PR_EXT:protein	denotes	proteins
T7085	25865-25871	GO:0030674	denotes	bridge
T7086	25903-25915	GO:0005856	denotes	cytoskeleton
T7087	25920-25931	GO:0005874	denotes	microtubule
T7088	25973-25981	GO:0005840	denotes	ribosome
T7089	25987-25994	PR_EXT:000043452	denotes	histone
T7090	25987-25994	CHEBI:15358	denotes	histone
T7091	25987-26006	GO_EXT:0004407	denotes	histone deacetylase
T7092	26007-26016	GO:0000785	denotes	chromatin
T7093	26007-26027	GO:0006338	denotes	chromatin remodeling
T7094	26046-26051	PR_EXT:000006937	denotes	egr-1
T7095	26056-26062	PR_EXT:P90916	denotes	lin-53
T7096	26068-26078	NCBITaxon:6239	denotes	C. elegans
T7097	26079-26089	SO_EXT:0000853	denotes	homologues
T7098	26097-26102	NCBITaxon:9606	denotes	human
T7099	26103-26108	PR_EXT:000010707	denotes	MTA-1
T7100	26113-26119	PR_EXT:000013776	denotes	RbAP48
T7101	26129-26142	GO_EXT:transcription	denotes	transcription
T7102	26129-26150	GO_EXT:transcription_factor	denotes	transcription factors
T7103	26163-26167	PR_EXT:P34766	denotes	PAL1
T7104	26185-26192	GO:0005634	denotes	nuclear
T7105	26193-26200	CHEBI_GO_EXT:hormone	denotes	hormone
T7106	26201-26209	GO_EXT:0004872	denotes	receptor
T1435	77-87	NCBITaxon:7742	denotes	vertebrate
T1436	92-104	NCBITaxon_EXT:invertebrate	denotes	invertebrate
T1437	114-122	SO_EXT:biological_sequence	denotes	Sequence
T1438	169-175	SO_EXT:0001026	denotes	genome
T1439	257-262	PR_EXT:000001856	denotes	RHAMM
T1440	263-274	SO_EXT:0000855	denotes	orthologues
T1441	301-312	SO_EXT:0001080	denotes	coiled coil
T3949	9722-9742	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T3950	9763-9768	SO_EXT:0000704	denotes	genes
T3951	9798-9802	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T3952	9803-9808	SO_EXT:0000704	denotes	genes
T3953	9839-9849	NCBITaxon:7742	denotes	vertebrate
T3954	9850-9855	PR_EXT:000016006	denotes	TACC1
T3955	9858-9863	SO_EXT:0000704	denotes	genes
T3956	9900-9919	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal regions
T3957	9935-9939	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T3958	9940-9944	SO_EXT:0000704	denotes	gene
T3959	9955-9961	NCBITaxon:9606	denotes	humans
T3960	9963-9968	NCBITaxon:10088	denotes	mouse
T3961	9977-9985	NCBITaxon:6656	denotes	arthopod
T3962	9986-10001	NCBITaxon:7227	denotes	D. melanogaster
T3963	10020-10032	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T3964	10036-10046	_FRAGMENT	denotes	paralogous
T3965	10059-10067	SO_EXT:0000854	denotes	segments
T3966	10047-10067	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T3967	10082-10091	NCBITaxon:1	denotes	organisms
T3968	10191-10210	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T3969	10215-10225	SO_EXT:sequence_duplication_process	denotes	duplicated
T3970	10239-10249	NCBITaxon:7742	denotes	vertebrate
T3971	10276-10287	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T3972	10310-10315	NCBITaxon:9606	denotes	human
T4005	11963-11975	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T4090	14241-14251	_FRAGMENT	denotes	paralogous
T4091	14264-14271	SO_EXT:0000854	denotes	segment
T4092	14252-14271	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T4093	14273-14282	SO_EXT:biological_conservation_process_or_quality	denotes	Conserved
T4094	14283-14293	SO:0000859	denotes	paralogous
T4095	14349-14354	SO_EXT:0000704	denotes	genes
T4096	14387-14394	SO_EXT:0001026	denotes	genomic
T4097	14395-14401	SO_EXT:0000149	denotes	contig
T4098	14483-14493	_FRAGMENT	denotes	paralogous
T4099	14506-14514	SO_EXT:0000854	denotes	segments
T4100	14494-14514	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T4101	14531-14542	NCBITaxon:7742	denotes	vertebrates
T4102	14561-14567	SO_EXT:0001026	denotes	genome
T4103	14575-14586	NCBITaxon:7712	denotes	urochordate
T4104	14587-14602	NCBITaxon:7719	denotes	C. intestinalis
T4105	14627-14638	SO_EXT:0000855	denotes	orthologues
T4106	14642-14646	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T4107	14652-14657	PR_EXT:000030426	denotes	WHSC1
T4108	14659-14675	GO_EXT:0004180	denotes	carboxypeptidase
T4109	14659-14677	PR_EXT:000005841	denotes	carboxypeptidase Z
T4110	14713-14714	CHEBI_SO_EXT:base	denotes	b
T4111	14729-14744	NCBITaxon:7719	denotes	C. intestinalis
T4112	14745-14751	SO_EXT:0001026	denotes	genome
T4113	14760-14765	NCBITaxon:9606	denotes	human
T4114	14766-14777	SO_EXT:0000855	denotes	orthologues
T4115	14802-14821	SO_EXT:0000854	denotes	paralogous segments
T4116	14925-14930	SO_EXT:0000704	denotes	genes
T4117	14940-14950	NCBITaxon:7742	denotes	vertebrate
T4118	14951-14970	SO_EXT:0000854	denotes	paralogous segments
R8157	T12593	T12592	_lexicallyChainedTo	on chromosome,region
R8158	T12602	T12601	_lexicallyChainedTo	regions,syntenic
R810	T1582	T1581	_lexicallyChainedTo	chromosome,region of
R2438	T3965	T3964	_lexicallyChainedTo	segments,paralogous
R2439	T3981	T3980	_lexicallyChainedTo	segments,paralogous
R2440	T4084	T4083	_lexicallyChainedTo	chromosome,regions of
R2441	T4091	T4090	_lexicallyChainedTo	segment,paralogous
R2442	T4099	T4098	_lexicallyChainedTo	segments,paralogous
R4062	T6313	T6312	_lexicallyChainedTo	organism,development of
R4063	T6376	T6375	_lexicallyChainedTo	metabolism,cellular
R4425	T7082	T7081	_lexicallyChainedTo	lin36,C. elegans
R5174	T8231	T8230	_lexicallyChainedTo	protein,binding site for
R5175	T8235	T8234	_lexicallyChainedTo	translation,control of
R5176	T8255	T8254	_lexicallyChainedTo	transport,RNA
R8280	T12796	T12795	_lexicallyChainedTo	chromosome,arm of
R8281	T12807	T12806	_lexicallyChainedTo	chromosome,arm of
R8790	T13604	T13603	_lexicallyChainedTo	transport,RNA

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T1319	77-87	NCBITaxon:7742	denotes	vertebrate
T1320	169-175	SO:0001026	denotes	genome
T1321	257-262	PR:000001856	denotes	RHAMM
T1322	263-274	SO:0000855	denotes	orthologues
T1323	301-312	SO:0001080	denotes	coiled coil
T1324	345-352	NCBITaxon:species	denotes	species
T1325	413-418	SO:0000704	denotes	genes
T1326	552-561	NCBITaxon:1	denotes	organisms
T1327	655-665	NCBITaxon:7742	denotes	vertebrate
T1328	666-673	NCBITaxon:species	denotes	species
T1329	679-692	NCBITaxon:7586	denotes	echinodermate
T1330	693-722	NCBITaxon:7668	denotes	Strongylocentrotus purpuratus
T1331	731-741	NCBITaxon:33317	denotes	protostome
T1332	742-748	NCBITaxon:6960	denotes	insect
T1337	946-955	NCBITaxon:1	denotes	organisms
T1338	997-1002	SO:0000704	denotes	genes
T1339	1105-1115	NCBITaxon:33213	denotes	bilaterian
T1340	1116-1125	NCBITaxon:33208	denotes	metazoans
T1341	1135-1143	NCBITaxon:6073	denotes	Cnidaria
T1342	1147-1155	NCBITaxon:6040	denotes	Porifera
T1343	1210-1219	NCBITaxon:1	denotes	organisms
T1344	1277-1283	SO:0000417	denotes	domain
T1345	1316-1324	NCBITaxon:33208	denotes	metazoan
T1346	1325-1334	NCBITaxon:1	denotes	organisms
T1347	1847-1848	SO:0001080	denotes	c
T1348	1857-1859	NCBITaxon:7711	denotes	ra
T1349	1886-1890	SO:0000704	denotes	gene
T1350	1913-1919	SO:0001026	denotes	genome
T1351	1927-1938	NCBITaxon:7712	denotes	urochordate
T1352	1939-1957	NCBITaxon:7719	denotes	Ciona intestinalis
T1353	2016-2035	NCBITaxon:7729	denotes	Halocynthia rortezi
T1354	2036-2039	SO:0000345	denotes	EST
T1355	2112-2116	SO:0000704	denotes	gene
T1356	2136-2144	NCBITaxon:7711	denotes	chordate
T1357	2200-2208	NCBITaxon:7711	denotes	chordate
T1358	2209-2215	SO:0001026	denotes	genome
T1359	2323-2331	NCBITaxon:7711	denotes	chordate
T1360	2332-2338	SO:0001026	denotes	genome
T1361	2413-2418	SO:0000704	denotes	genes
T1362	2489-2494	SO:0000704	denotes	genes
T1363	2527-2537	NCBITaxon:7742	denotes	vertebrate
T1364	2538-2544	SO:0001026	denotes	genome
T1365	2568-2578	NCBITaxon:31031	denotes	pufferfish
T1366	2579-2596	NCBITaxon:31033	denotes	Takifugu rubripes
T1367	2609-2614	SO:0000704	denotes	genes
T1368	2636-2641	NCBITaxon:9606	denotes	human
T1369	2642-2647	PR:000016006	denotes	TACC1
T1370	2695-2702	SO:0001026	denotes	genomic
T1371	2752-2757	SO:0000704	denotes	genes
T1372	2795-2799	SO:0000704	denotes	gene
T1373	2818-2823	PR:000016008	denotes	TACC3
T1374	2852-2857	SO:0000704	denotes	genes
T1375	2877-2888	NCBITaxon:31033	denotes	T. rubripes
T1376	2904-2909	SO:0000704	denotes	genes
T1377	2930-2941	NCBITaxon:31033	denotes	T. rubripes
T1378	2942-2953	SO:0000855	denotes	orthologues
T1379	2957-2962	NCBITaxon:9606	denotes	human
T1380	2963-2968	PR:000016007	denotes	TACC2
T1381	2973-2978	PR:000016008	denotes	TACC3
T1382	3003-3008	SO:0000704	denotes	genes
T1383	3060-3065	PR:000016006	denotes	TACC1
T1384	3104-3114	SO:0000857	denotes	homologous
T1385	3203-3207	SO:0000704	denotes	gene
T1386	3225-3230	SO:0000147	denotes	exons
T1387	3262-3270	NCBITaxon:31032	denotes	Takifugu
T1388	3271-3279	SO:0001248	denotes	Scaffold
T1389	3353-3357	SO:0000704	denotes	gene
T1390	3419-3424	SO:0000147	denotes	exons
T1391	3457-3463	SO:0000188	denotes	intron
T1392	3464-3468	SO:0000147	denotes	exon
T1393	3507-3511	SO:0000704	denotes	gene
T1394	3562-3572	NCBITaxon:31031	denotes	pufferfish
T1395	3652-3660	NCBITaxon:1	denotes	organism
T1396	3824-3829	SO:0000704	denotes	genes
T1397	3915-3922	NCBITaxon:32443	denotes	teleost
T1398	3923-3928	PR:000016006	denotes	TACC1
T1399	3969-3976	SO:0001026	denotes	genomic
T1400	4010-4017	NCBITaxon:32443	denotes	teleost
T1401	4055-4066	NCBITaxon:31033	denotes	T. rubripes
T1402	4131-4136	PR:000016008	denotes	TACC3
T1403	4182-4192	NCBITaxon:7742	denotes	vertebrate
T1404	4193-4200	SO:0001026	denotes	genomic
T1405	4236-4247	NCBITaxon:7742	denotes	vertebrates
T1406	4277-4283	GO:0008380	denotes	splice
T1407	4296-4301	PR:000016006	denotes	TACC1
T1408	4306-4311	PR:000016007	denotes	TACC2
T1409	4315-4327	NCBITaxon:10090	denotes	Mus musculus
T1410	4377-4388	SO:0000855	denotes	orthologues
T1411	4392-4397	PR:000016006	denotes	TACC1
T1412	4405-4420	NCBITaxon:10116	denotes	Rattus norvegus
T1413	4468-4473	NCBITaxon:10088	denotes	mouse
T1414	4474-4486	GO:0000805	denotes	chromosome X
T1415	4493-4497	SO:0000704	denotes	gene
T1416	4524-4529	NCBITaxon:10088	denotes	mouse
T1417	4530-4535	PR:000016006	denotes	TACC1
T1418	4577-4582	NCBITaxon:10088	denotes	mouse
T1419	4637-4643	SO:0000188	denotes	intron
T1420	4661-4671	GO:0010467	denotes	expression
T2546	6932-6938	NCBITaxon:9986	denotes	rabbit
T2505	5121-5131	NCBITaxon:7742	denotes	vertebrate
T2506	5132-5137	PR:000016008	denotes	TACC3
T2507	5138-5149	SO:0000855	denotes	orthologues
T2508	5214-5219	PR:000016008	denotes	TACC3
T2509	5220-5231	SO:0000855	denotes	orthologues
T2510	5323-5327	SO:0000704	denotes	gene
T2511	5399-5403	SO:0000704	denotes	gene
T2512	5443-5453	NCBITaxon:7742	denotes	vertebrate
T2513	5490-5501	NCBITaxon:31033	denotes	T. rubripes
T2514	5503-5510	NCBITaxon:9989	denotes	rodents
T2515	5515-5521	NCBITaxon:9606	denotes	humans
T2516	5547-5557	NCBITaxon:7742	denotes	vertebrate
T2517	5558-5563	PR:000016008	denotes	TACC3
T2518	5614-5621	SO:0001026	denotes	genomic
T2519	5673-5677	SO:0000704	denotes	gene
T2520	5787-5808	NCBITaxon:9986	denotes	Oryctolagus cuniculus
T2521	5931-5936	PR:000016008	denotes	TACC3
T2522	5986-5990	SO:0000704	denotes	gene
T2523	6016-6026	SO:0000673	denotes	transcript
T2524	6134-6139	NCBITaxon:9606	denotes	human
T2525	6144-6149	NCBITaxon:10088	denotes	mouse
T2526	6150-6155	PR:000016008	denotes	TACC3
T2527	6213-6219	NCBITaxon:9986	denotes	rabbit
T2528	6220-6225	PR:000016008	denotes	TACC3
T2529	6290-6296	NCBITaxon:9986	denotes	rabbit
T2530	6297-6302	PR:000016008	denotes	TACC3
T2531	6346-6351	NCBITaxon:9606	denotes	human
T2532	6356-6361	NCBITaxon:10088	denotes	mouse
T2533	6362-6367	PR:000016008	denotes	TACC3
T2534	6444-6449	NCBITaxon:9606	denotes	human
T2535	6454-6459	NCBITaxon:10088	denotes	mouse
T2536	6460-6465	PR:000016008	denotes	TACC3
T2537	6572-6577	SO:0000704	denotes	genes
T2538	6593-6602	SO:0000993	denotes	consensus
T2539	6619-6625	SO:0000112	denotes	primer
T2540	6738-6743	PR:000016008	denotes	TACC3
T2541	6755-6763	NCBITaxon:9443	denotes	primates
T2542	6768-6775	NCBITaxon:9989	denotes	rodents
T2543	6788-6794	SO:0000112	denotes	primer
T2544	6840-6846	SO:0000112	denotes	primer
T2545	6915-6926	SO:0000006	denotes	PCR product
T2547	6939-6944	UBERON:0000955	denotes	brain
T2548	7006-7015	SO:0000993	denotes	consensus
T2549	7029-7031	SO:0000028	denotes	bp
T2550	7057-7067	SO:0000673	denotes	transcript
T2551	7224-7242	GO:0000380	denotes	alternative splice
T2552	7294-7299	PR:000016008	denotes	TACC3
T2553	7300-7304	SO:0000704	denotes	gene
T2554	7343-7349	NCBITaxon:9986	denotes	rabbit
T2555	7361-7371	SO:0000673	denotes	transcript
T2556	7384-7390	NCBITaxon:9986	denotes	rabbit
T2557	7414-7434	SO:0002138	denotes	predicted transcript
T2558	7447-7452	PR:000016008	denotes	TACC3
T2559	7799-7805	NCBITaxon:9986	denotes	rabbit
T2560	7822-7828	NCBITaxon:9986	denotes	rabbit
T2561	7829-7834	PR:000016008	denotes	TACC3
T2562	7945-7950	PR:000016008	denotes	TACC3
T2563	7951-7962	SO:0000855	denotes	orthologues
T2564	7982-7996	NCBITaxon:8355	denotes	Xenopus laevis
T2565	8024-8029	PR:000016008	denotes	TACC3
T2566	8043-8058	NCBITaxon:10116	denotes	Rattus norvegus
T2567	8060-8073	NCBITaxon:9031	denotes	Gallus gallus
T2568	8075-8094	NCBITaxon:8364	denotes	Silurana tropicalis
T2569	8096-8107	NCBITaxon:7955	denotes	Danio rerio
T2570	8112-8123	NCBITaxon:31033	denotes	T. rubripes
T3321	8290-8295	PR:000001856	denotes	RHAMM
T3322	8296-8300	SO:0000704	denotes	gene
T3323	8325-8336	SO:0001080	denotes	coiled coil
T3324	8337-8341	SO:0000704	denotes	gene
T3325	8349-8354	NCBITaxon:9606	denotes	Human
T3326	8355-8360	PR:000001856	denotes	RHAMM
T3327	8525-8531	NCBITaxon:9606	denotes	humans
T3328	8582-8593	SO:0001080	denotes	coiled coil
T3329	8594-8600	SO:0000417	denotes	domain
T3330	8613-8619	SO:0000417	denotes	domain
T3331	8660-8665	PR:000001856	denotes	RHAMM
T3332	8681-8691	GO:0005813	denotes	centrosome
T3333	8705-8710	PR:000001856	denotes	RHAMM
T3334	8883-8893	NCBITaxon:7742	denotes	vertebrate
T3335	8894-8900	SO:0001026	denotes	genome
T3336	8931-8936	PR:000001856	denotes	RHAMM
T3337	8937-8948	SO:0000855	denotes	orthologues
T3338	8961-8966	SO:0000704	denotes	genes
T3339	8970-8979	NCBITaxon:33208	denotes	metazoans
T3340	9022-9033	SO:0001080	denotes	coiled coil
T3341	9090-9095	PR:000001856	denotes	RHAMM
T3342	9096-9100	SO:0000704	denotes	gene
T3343	9108-9121	NCBITaxon:33511	denotes	deuterostomes
T3344	9144-9151	SO:0001026	denotes	genomic
T3345	9186-9201	NCBITaxon:7719	denotes	C. intestinalis
T3346	9206-9211	PR:000001856	denotes	RHAMM
T3347	9212-9216	SO:0000704	denotes	gene
T3348	9235-9242	NCBITaxon:6960	denotes	insects
T3349	9246-9255	NCBITaxon:6231	denotes	nematodes
T3350	9281-9286	PR:000001856	denotes	RHAMM
T3351	9292-9297	SO:0000704	denotes	genes
T3352	9317-9327	NCBITaxon:33317	denotes	protostome
T3353	9328-9340	NCBITaxon:33511	denotes	deuterostome
T3354	9377-9390	NCBITaxon:7586	denotes	echinodermata
T3355	9391-9402	NCBITaxon:7712	denotes	urochordate
T3356	9479-9490	SO:0001080	denotes	coiled coil
T3357	9528-9533	PR:000001856	denotes	RHAMM
T3358	9558-9564	SO:0000417	denotes	domain
T3359	9620-9631	SO:0001080	denotes	coiled coil
T3360	9698-9702	SO:0000704	denotes	gene
T3806	9940-9944	SO:0000704	denotes	gene
T3807	9955-9961	NCBITaxon:9606	denotes	humans
T3808	9963-9968	NCBITaxon:10088	denotes	mouse
T3809	9977-9985	NCBITaxon:6656	denotes	arthopod
T3810	9986-10001	NCBITaxon:7227	denotes	D. melanogaster
T3811	10036-10046	_FRAGMENT	denotes	paralogous
T3812	10059-10067	SO:0000854	denotes	segments
T3813	10082-10091	NCBITaxon:1	denotes	organisms
T3814	10239-10249	NCBITaxon:7742	denotes	vertebrate
T3815	10310-10315	NCBITaxon:9606	denotes	human
T3816	10345-10350	NCBITaxon:9606	denotes	human
T3817	10493-10497	SO:0000704	denotes	gene
T3818	10591-10601	_FRAGMENT	denotes	paralogous
T3819	10614-10622	SO:0000854	denotes	segments
T3820	10718-10722	SO:0000704	denotes	gene
T3821	10726-10737	NCBITaxon:7742	denotes	vertebrates
T3822	10785-10790	PR:000001451	denotes	FGFR4
T3823	10848-10853	PR:000001856	denotes	RHAMM
T3824	10854-10858	SO:0000704	denotes	gene
T3825	10896-10901	NCBITaxon:9606	denotes	Human
T3826	10902-10907	PR:000001856	denotes	RHAMM
T3827	10955-10959	PR:000008212	denotes	GPX3
T3828	10964-10969	PR:000011245	denotes	NKX2E
T3829	11007-11012	SO:0000704	denotes	genes
T3830	11016-11021	NCBITaxon:9606	denotes	human
T3831	11044-11054	SO:0000859	denotes	paralogous
T3832	11142-11147	NCBITaxon:10088	denotes	mouse
T3833	11152-11155	NCBITaxon:10114	denotes	rat
T3834	11206-11211	SO:0000704	denotes	genes
T3835	11254-11261	NCBITaxon:9443	denotes	primate
T3836	11262-11268	NCBITaxon:9989	denotes	rodent
T3837	11979-11983	SO:0000704	denotes	gene
T3838	12033-12037	SO:0000704	denotes	gene
T3839	12038-12048	GO:0065007	denotes	regulation
T3840	12100-12119	SO:0000854	denotes	paralogous segments
T3841	12137-12143	SO:0001026	denotes	genome
T3842	12151-12159	NCBITaxon:7712	denotes	tunicate
T3843	12160-12175	NCBITaxon:7719	denotes	C. intestinalis
T3844	12214-12224	NCBITaxon:7742	denotes	vertebrate
T3845	12225-12231	SO:0001026	denotes	genome
T3846	12251-12262	NCBITaxon:31033	denotes	T. rubripes
T3847	12318-12324	SO:0001026	denotes	genome
T3848	12328-12339	NCBITaxon:31033	denotes	T. rubripes
T3849	12387-12397	SO:0000859	denotes	paralogous
T3850	12423-12434	NCBITaxon:7742	denotes	vertebrates
T3851	12463-12474	SO:0000855	denotes	orthologues
T3852	12478-12484	PR:000008258	denotes	GPRK2L
T3853	12489-12494	PR:000013947	denotes	RGS12
T3854	12508-12519	NCBITaxon:31033	denotes	T. rubripes
T3855	12520-12528	SO:0001248	denotes	scaffold
T3856	12590-12595	NCBITaxon:9606	denotes	human
T3857	12606-12617	NCBITaxon:31033	denotes	T. rubripes
T3858	12618-12629	SO:0000855	denotes	orthologues
T3859	12633-12638	PR:000001450	denotes	FGFR3
T3864	12782-12787	SO:0000704	denotes	genes
T3865	12855-12860	PR:000016008	denotes	TACC3
T3866	12865-12870	PR:000007506	denotes	FGFRL
T3867	12894-12903	SO:0001248	denotes	scaffolds
T3868	12963-12967	SO:0000704	denotes	gene
T3869	13002-13007	PR:000008260	denotes	GPRK6
T3870	13011-13016	NCBITaxon:9606	denotes	human
T3871	13059-13069	NCBITaxon:31031	denotes	pufferfish
T3872	13080-13091	NCBITaxon:31033	denotes	T. rubripes
T3873	13092-13103	SO:0000855	denotes	orthologues
T3874	13107-13111	PR:000011441	denotes	NSD1
T3875	13113-13118	PR:000001451	denotes	FGFR4
T3876	13134-13138	SO:0000704	denotes	gene
T3877	13150-13158	SO:0001248	denotes	scaffold
T3878	13219-13223	SO:0000704	denotes	gene
T3879	13249-13253	SO:0000704	denotes	gene
T3880	13368-13373	PR:000016006	denotes	TACC1
T3881	13382-13387	SO:0000704	denotes	genes
T3882	13395-13405	NCBITaxon:31031	denotes	pufferfish
T3883	13441-13449	SO:0001248	denotes	scaffold
T3884	13500-13511	SO:0000855	denotes	orthologues
T3885	13523-13528	SO:0000704	denotes	genes
T3886	13540-13545	NCBITaxon:9606	denotes	human
T3887	13577-13585	SO:0001248	denotes	scaffold
T3888	13618-13623	PR:000016006	denotes	TACC1
T3889	13670-13681	NCBITaxon:7742	denotes	vertebrates
T3890	13715-13719	SO:0000704	denotes	gene
T3891	13745-13753	SO:0001248	denotes	scaffold
T3892	13782-13790	SO:0001248	denotes	scaffold
T3893	13809-13820	NCBITaxon:31033	denotes	T. rubripes
T3894	13821-13832	SO:0000855	denotes	orthologues
T3895	13836-13840	PR:000010686	denotes	MSX1
T3896	13842-13847	PR:000015790	denotes	STX18
T3897	13865-13879	SO:0000996	denotes	predicted gene
T3898	13921-13929	SO:0000857	denotes	homology
T3899	13933-13937	PR:000009884	denotes	LOXL
T3900	13939-13942	PR:000007232	denotes	EVC
T3901	13981-13989	SO:0001248	denotes	scaffold
T3902	14002-14007	SO:0000704	denotes	genes
T3903	14032-14037	NCBITaxon:9606	denotes	human
T3904	14089-14094	PR:000016008	denotes	TACC3
T3905	14099-14104	PR:000016007	denotes	TACC2
T3906	14164-14171	SO:0001026	denotes	genomic
T3907	14241-14251	_FRAGMENT	denotes	paralogous
T3908	14264-14271	SO:0000854	denotes	segment
T3909	14283-14293	SO:0000859	denotes	paralogous
T3910	14349-14354	SO:0000704	denotes	genes
T3911	14387-14394	SO:0001026	denotes	genomic
T3912	14395-14401	SO:0000149	denotes	contig
T3913	14483-14493	_FRAGMENT	denotes	paralogous
T3914	14506-14514	SO:0000854	denotes	segments
T3915	14531-14542	NCBITaxon:7742	denotes	vertebrates
T3916	14561-14567	SO:0001026	denotes	genome
T3917	14575-14586	NCBITaxon:7712	denotes	urochordate
T3918	14587-14602	NCBITaxon:7719	denotes	C. intestinalis
T3919	14627-14638	SO:0000855	denotes	orthologues
T3920	14652-14657	PR:000030426	denotes	WHSC1
T3921	14659-14677	PR:000005841	denotes	carboxypeptidase Z
T3922	14729-14744	NCBITaxon:7719	denotes	C. intestinalis
T3923	14745-14751	SO:0001026	denotes	genome
T3924	14760-14765	NCBITaxon:9606	denotes	human
T3925	14766-14777	SO:0000855	denotes	orthologues
T3926	14802-14821	SO:0000854	denotes	paralogous segments
T3927	14925-14930	SO:0000704	denotes	genes
T3928	14940-14950	NCBITaxon:7742	denotes	vertebrate
T3929	14951-14970	SO:0000854	denotes	paralogous segments
T3930	15003-15008	PR:000001856	denotes	RHAMM
T3931	15009-15014	SO:0000704	denotes	genes
T3932	15018-15033	NCBITaxon:7719	denotes	C. intestinalis
T3933	15084-15103	SO:0000854	denotes	paralogous segments
T3934	15131-15136	SO:0000704	denotes	genes
T3935	15234-15243	NCBITaxon:7712	denotes	tunicates
T3936	15288-15299	NCBITaxon:31033	denotes	T. rubripes
T3937	15300-15306	SO:0001026	denotes	genome
T3938	15437-15442	PR:000001450	denotes	FGFR3
T3939	15477-15481	SO:0000704	denotes	gene
T3940	15498-15502	SO:0000704	denotes	gene
T3941	15526-15536	NCBITaxon:7742	denotes	vertebrate
T3942	15579-15591	NCBITaxon:61463	denotes	Gnanthostome
T3943	15666-15684	SO:0000854	denotes	paralogous segment
T3944	15718-15727	NCBITaxon:7737	denotes	amphioxus
T3945	15732-15739	NCBITaxon:7745	denotes	lamprey
T3946	15740-15747	SO:0001026	denotes	genomes
T3947	15774-15778	SO:0000704	denotes	gene
T3948	15850-15855	SO:0000704	denotes	genes
T5266	17053-17060	SO:0001026	denotes	genomic
T5267	17094-17101	SO:0001026	denotes	genomic
T5268	17137-17148	SO:0000858	denotes	orthologous
T5269	17154-17159	SO:0000704	denotes	genes
T5270	17163-17168	NCBITaxon:9606	denotes	human
T5271	17170-17175	NCBITaxon:10088	denotes	mouse
T5272	17177-17180	NCBITaxon:10114	denotes	rat
T5273	17182-17192	NCBITaxon:31031	denotes	pufferfish
T5274	17194-17209	NCBITaxon:7719	denotes	C. intestinalis
T5275	17211-17226	NCBITaxon:7227	denotes	D. melanogaster
T5276	17231-17241	NCBITaxon:6239	denotes	C. elegans
T5277	17309-17316	SO:0001026	denotes	genomic
T5278	17340-17344	SO:0000704	denotes	gene
T5279	17365-17368	NCBITaxon:10114	denotes	rat
T5280	17373-17383	NCBITaxon:31031	denotes	pufferfish
T5281	17385-17390	SO:0000147	denotes	exons
T5282	17446-17456	GO:0006412	denotes	translated
T5283	17487-17492	NCBITaxon:10088	denotes	mouse
T5284	17497-17502	NCBITaxon:9606	denotes	human
T5285	17557-17568	NCBITaxon:31033	denotes	T. rubripes
T5286	17570-17577	SO:0001026	denotes	genomic
T5287	17604-17609	CHEBI:15377	denotes	water
T5288	17610-17620	NCBITaxon:31031	denotes	pufferfish
T5289	17622-17644	NCBITaxon:99883	denotes	Tetraodon nigroviridis
T5290	17699-17704	SO:0000147	denotes	exons
T5291	17740-17745	SO:0000704	denotes	genes
T5292	17838-17844	SO:0000417	denotes	domain
T5293	17916-17926	NCBITaxon:6239	denotes	C. elegans
T5294	18028-18033	SO:0000147	denotes	exons
T5295	18041-18045	SO:0000704	denotes	gene
T5296	18061-18070	NCBITaxon:1	denotes	organisms
T5297	18072-18087	NCBITaxon:7227	denotes	D. melanogaster
T5298	18097-18110	NCBITaxon:33511	denotes	deuterostomes
T5299	18111-18126	NCBITaxon:7719	denotes	C. intestinalis
T5300	18130-18135	NCBITaxon:9606	denotes	human
T5301	18179-18184	SO:0000147	denotes	exons
T5302	18192-18196	SO:0000704	denotes	gene
T5303	18206-18221	NCBITaxon:7227	denotes	D. melanogaster
T5304	18236-18248	NCBITaxon:33511	denotes	deuterostome
T5305	18249-18254	SO:0000704	denotes	genes
T5306	18277-18283	SO:0000417	denotes	domain
T5307	18337-18345	SO:0000857	denotes	homology
T5308	18380-18384	SO:0000704	denotes	gene
T5309	18404-18408	SO:0000147	denotes	exon
T5310	18460-18471	SO:0000855	denotes	orthologues
T5311	18521-18526	PR:000016008	denotes	TACC3
T5312	18527-18532	SO:0000704	denotes	genes
T5313	18540-18551	NCBITaxon:7742	denotes	vertebrates
T5314	18568-18581	NCBITaxon:33511	denotes	deuterostomes
T5315	18588-18592	SO:0000147	denotes	exon
T5316	18640-18646	NCBITaxon:39107	denotes	murine
T5317	18647-18654	PR:000016008	denotes	TACC3's
T5318	18658-18664	NCBITaxon:9989	denotes	rodent
T5319	18741-18777	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T5320	18749-18769	GO:0006338	denotes	chromatin remodeling
T5321	18788-18793	PR:000017527	denotes	GAS41
T5322	18810-18820	NCBITaxon:7742	denotes	vertebrate
T5323	18840-18845	PR:000016008	denotes	TACC3
T5324	18846-18857	SO:0000855	denotes	orthologues
T5325	18955-18958	NCBITaxon:10114	denotes	rat
T5326	18959-18964	PR:000016008	denotes	TACC3
T5327	19000-19011	NCBITaxon:7955	denotes	Danio rerio
T5328	19077-19084	SO:0001026	denotes	genomic
T5329	19102-19107	PR:000016008	denotes	TACC3
T5330	19108-19119	SO:0000855	denotes	orthologues
T5331	19121-19126	PR:000016008	denotes	TACC3
T5332	19231-19236	SO:0000147	denotes	exons
T5333	19253-19263	NCBITaxon:7742	denotes	vertebrate
T5334	19264-19269	PR:000016008	denotes	TACC3
T5335	19270-19274	SO:0000704	denotes	gene
T5336	19295-19301	SO:0000417	denotes	domain
T5337	19335-19340	SO:0000147	denotes	exons
T5338	19461-19466	PR:000016008	denotes	TACC3
T5339	19479-19484	NCBITaxon:9606	denotes	human
T5340	19489-19494	NCBITaxon:10088	denotes	mouse
T5341	19578-19589	SO:0000855	denotes	orthologues
T5342	19689-19693	SO:0000147	denotes	exon
T5343	19697-19702	NCBITaxon:9606	denotes	human
T5344	19711-19721	NCBITaxon:31031	denotes	pufferfish
T5345	19745-19752	NCBITaxon:9989	denotes	rodents
T5346	19865-19869	SO:0000147	denotes	exon
T5347	19877-19882	NCBITaxon:10088	denotes	mouse
T5348	19887-19890	NCBITaxon:10114	denotes	rat
T5349	19891-19896	PR:000016008	denotes	TACC3
T5350	19897-19902	SO:0000704	denotes	genes
T5351	19956-19961	NCBITaxon:10088	denotes	mouse
T5352	19962-19967	PR:000016008	denotes	TACC3
T5353	19968-19974	GO:0008380	denotes	splice
T5354	20078-20082	SO:0000147	denotes	exon
T5355	20406-20412	NCBITaxon:9986	denotes	rabbit
T5356	20475-20481	NCBITaxon:9989	denotes	rodent
T5357	20482-20487	PR:000016008	denotes	TACC3
T5358	20554-20563	NCBITaxon:8292	denotes	amphibian
T5359	20564-20571	NCBITaxon:8353	denotes	Xenopus
T5360	20572-20577	PR:000016008	denotes	TACC3
T6239	20592-20612	GO:0000380	denotes	Alternative splicing
T6240	20616-20626	NCBITaxon:7742	denotes	vertebrate
T6241	20632-20637	SO:0000704	denotes	genes
T6242	20646-20650	SO:0000147	denotes	exon
T6243	20705-20709	SO:0000704	denotes	gene
T6244	20763-20769	UBERON:0000479	denotes	tissue
T6245	20779-20799	GO:0000380	denotes	alternative splicing
T6246	20805-20809	SO:0000704	denotes	gene
T6247	20866-20870	SO:0000704	denotes	gene
T6248	20882-20896	_FRAGMENT	denotes	development of
T6249	20900-20908	GO:0044767	denotes	organism
T6250	20900-20908	NCBITaxon:1	denotes	organism
T6251	20922-20942	GO:0000380	denotes	alternative splicing
T6252	20946-20951	PR:000016008	denotes	TACC3
T6253	20999-21005	UBERON:0000479	denotes	tissue
T6254	21015-21023	GO:0008380	denotes	splicing
T6255	21043-21048	PR:000016006	denotes	TACC1
T6256	21053-21058	PR:000016007	denotes	TACC2
T6257	21059-21064	SO:0000704	denotes	genes
T6258	21081-21086	PR:000016007	denotes	TACC2
T6259	21115-21119	SO:0000147	denotes	exon
T6260	21171-21177	GO:0008380	denotes	splice
T6261	21194-21204	NCBITaxon:7742	denotes	vertebrate
T6262	21205-21210	PR:000016007	denotes	TACC2
T6263	21211-21216	SO:0000704	denotes	genes
T6264	21226-21246	GO:0000380	denotes	alternative splicing
T6265	21255-21259	SO:0000147	denotes	exon
T6266	21315-21320	PR:000016007	denotes	TACC2
T6267	21321-21329	SO:0001060	denotes	isoforms
T6268	21398-21403	PR:000016007	denotes	TACC2
T6269	21442-21447	PR:000016006	denotes	TACC1
T6270	21500-21507	SO:0001060	denotes	isoform
T6271	21528-21548	GO:0000380	denotes	Alternative splicing
T6272	21577-21585	SO:0000167	denotes	promoter
T6273	21623-21628	NCBITaxon:9606	denotes	human
T6274	21629-21634	PR:000016006	denotes	TACC1
T6275	21635-21639	SO:0000704	denotes	gene
T6276	21712-21717	PR:000016006	denotes	TACC1
T6277	21718-21726	SO:0001060	denotes	isoforms
T6278	21744-21764	GO:0000380	denotes	alternative splicing
T6279	21768-21773	SO:0000147	denotes	exons
T6280	21814-21822	SO:0001060	denotes	isoforms
T6281	21905-21917	SO:0000409	denotes	binding site
T6282	21922-21926	PR:000009965	denotes	LSm7
T6283	21965-21972	GO:0005634	denotes	nuclear
T6284	21965-21993	SO:0001528	denotes	nuclear localization signals
T6285	21998-22010	SO:0000409	denotes	binding site
T6286	22015-22020	PR:000017527	denotes	GAS41
T6287	22030-22040	PR:000029784	denotes	PCTAIRE2BP
T6288	22047-22055	SO:0001060	denotes	isoforms
T6289	22078-22086	SO:0001060	denotes	isoforms
T6290	22127-22136	GO:0005737	denotes	cytoplasm
T6291	22171-22179	SO:0001060	denotes	isoforms
T6292	22231-22239	GO:0000785	denotes	chomatin
T6293	22231-22250	GO:0006338	denotes	chomatin remodeling
T6294	22258-22272	GO:0006396	denotes	RNA processing
T6295	22290-22297	GO:0005634	denotes	nucleus
T6296	22334-22339	PR:000016006	denotes	TACC1
T6297	22340-22348	SO:0001060	denotes	isoforms
T6298	22390-22398	_FRAGMENT	denotes	cellular
T6299	22403-22413	GO:0044237	denotes	metabolism
T6300	22399-22413	GO:0016070	denotes	RNA metabolism
T6301	22493-22501	SO:0001060	denotes	isoforms
T6302	22545-22559	UBERON:0001199	denotes	gastric mucosa
T6914	23845-23852	SO:0001026	denotes	genomic
T6915	24026-24032	SO:0000417	denotes	domain
T6916	24104-24111	GO:0007067	denotes	mitotic
T6917	24104-24119	GO:0072686	denotes	mitotic spindle
T6918	24124-24135	GO:0005813	denotes	centrosomal
T6919	24263-24272	SO:0000853	denotes	homologue
T6920	24283-24289	PR:P39723	denotes	spc-72
T6921	24307-24312	NCBITaxon:9606	denotes	human
T6922	24418-24424	SO:0000417	denotes	domain
T6923	24435-24446	GO:0005874	denotes	microtubule
T6924	24447-24458	GO:0005813	denotes	centrosomal
T6925	24475-24479	PR:P46675	denotes	stu2
T6926	24480-24484	PR:Q9VEZ3	denotes	msps
T6927	24485-24491	PR:000005512	denotes	ch-TOG
T6928	24525-24539	PR:000035365	denotes	Aurora kinases
T6929	24620-24625	PR:P39723	denotes	spc72
T6930	24638-24643	PR:000016008	denotes	TACC3
T6931	24660-24670	GO:0005813	denotes	centrosome
T6932	24728-24738	GO:0005813	denotes	centrosome
T6933	24743-24750	GO:0007067	denotes	mitotic
T6934	24743-24758	GO:0072686	denotes	mitotic spindle
T6935	24867-24872	NCBITaxon:9606	denotes	human
T6936	24937-24951	PR:000035365	denotes	Aurora kinases
T6937	24967-24972	PR:000016006	denotes	TACC1
T6938	24977-24982	PR:000016008	denotes	TACC3
T6939	24997-25012	PR:000004515	denotes	Aurora A kinase
T6940	25022-25027	PR:000016007	denotes	TACC2
T6941	25043-25058	PR:000004518	denotes	Aurora C kinase
T6942	25150-25158	NCBITaxon:7711	denotes	chordate
T6943	25192-25202	NCBITaxon:7742	denotes	vertebrate
T6944	25208-25213	SO:0000704	denotes	genes
T6945	25239-25249	NCBITaxon:7742	denotes	vertebrate
T6946	25271-25281	GO:0051325	denotes	interphase
T6947	25282-25289	GO:0005634	denotes	nucleus
T6948	25380-25390	GO:0005813	denotes	centrosome
T6949	25395-25406	GO:0005874	denotes	microtubule
T6950	25395-25415	GO:0000226	denotes	microtubule dynamics
T6951	25467-25478	NCBITaxon:33317	denotes	protostomes
T6952	25483-25496	NCBITaxon:33511	denotes	deuterostomes
T6953	25555-25560	SO:0000704	denotes	genes
T6954	25581-25586	SO:0000147	denotes	exons
T6955	25647-25657	NCBITaxon:6239	denotes	C. elegans
T6956	25662-25677	NCBITaxon:7227	denotes	D. melanogaster
T6957	25809-25819	NCBITaxon:6239	denotes	C. elegans
T6958	25809-25826	PR:Q27365	denotes	C. elegans lin15A
T6959	25809-25819	_FRAGMENT	denotes	C. elegans
T6960	25828-25833	PR:P34427	denotes	lin36
T6961	25838-25843	PR:000009822	denotes	lin37
T6984	26465-26482	GO:0006281	denotes	DNA damage repair
T6985	26564-26574	GO:0006281	denotes	DNA repair
T6986	26615-26625	NCBITaxon:6239	denotes	C. elegans
T6987	26626-26631	PR:000004642	denotes	BARD1
T6988	26632-26642	SO:0000855	denotes	orthologue
T6989	26732-26741	NCBITaxon:1	denotes	organisms
T6990	26880-26884	PR:P46675	denotes	stu2
T6991	26885-26889	PR:Q9VEZ3	denotes	msps
T6992	26890-26896	PR:000005512	denotes	ch-TOG
T6993	28067-28073	SO:0000417	denotes	domain
T6994	28141-28151	NCBITaxon:6239	denotes	C. elegans
T6995	28156-28171	NCBITaxon:7227	denotes	D. melanogaster
T6996	28200-28207	NCBITaxon:33208	denotes	animals
T6997	28316-28326	NCBITaxon:7742	denotes	vertebrate
T6998	28376-28386	NCBITaxon:6239	denotes	C. elegans
T6999	28405-28411	PR:Q27365	denotes	lin15A
T7000	28413-28418	PR:P34427	denotes	lin36
T7001	28423-28428	PR:000009822	denotes	lin37
T7002	28461-28471	SO:0000853	denotes	homologues
T7003	28475-28486	NCBITaxon:7742	denotes	vertebrates
T7004	28490-28500	NCBITaxon:7215	denotes	Drosophila
T7005	28541-28547	SO:0000417	denotes	domain
T7006	28551-28556	PR:P34427	denotes	lin36
T7007	28744-28749	PR:000016057	denotes	TDP43
T7008	28791-28801	GO:0065007	denotes	regulation
T7009	28806-28814	GO:0008380	denotes	splicing
T7010	28855-28860	NCBITaxon:9606	denotes	human
T7011	28861-28870	SO:0000853	denotes	homologue
T7012	28929-28934	NCBITaxon:9606	denotes	human
T7013	29020-29025	SO:0001980	denotes	G-box
T8091	29113-29123	NCBITaxon:7742	denotes	vertebrate
T8092	29167-29177	NCBITaxon:7742	denotes	vertebrate
T8093	29364-29374	NCBITaxon:7742	denotes	vertebrate
T8094	29477-29487	GO:0005813	denotes	centrosome
T8095	29488-29495	GO:0007067	denotes	mitotic
T8096	29488-29503	GO:0072686	denotes	mitotic spindle
T8097	29542-29546	SO:0000704	denotes	gene
T8098	29547-29557	GO:0065007	denotes	regulation
T8099	29611-29625	GO:0006396	denotes	RNA processing
T8100	29630-29641	GO:0006412	denotes	translation
T8101	29797-29812	GO:0043234	denotes	protein complex
T8102	29889-29899	GO:0005813	denotes	centrosome
T8103	29920-29935	GO:0072686	denotes	mitotic spindle
T8104	29920-29944	GO:0090307	denotes	mitotic spindle assembly
T8105	30043-30053	NCBITaxon:7742	denotes	vertebrate
T8106	30054-30059	PR:000016008	denotes	TACC3
T8107	30164-30171	GO:0007067	denotes	mitosis
T8108	30206-30221	PR:000004515	denotes	Aurora Kinase A
T8109	30263-30268	NCBITaxon:9606	denotes	human
T8110	30358-30364	SO:0000417	denotes	domain
T8111	30372-30382	NCBITaxon:7742	denotes	vertebrate
T8112	30383-30394	SO:0000855	denotes	orthologues
T8113	30410-30415	PR:000016008	denotes	TACC3
T8114	30474-30481	NCBITaxon:species	denotes	species
T8115	30519-30528	NCBITaxon:8355	denotes	X. laevis
T8116	30564-30580	_FRAGMENT	denotes	binding site for
T8117	30591-30598	SO:0000410	denotes	protein
T8118	30585-30590	PR:000006990	denotes	eIF4E
T8119	30639-30649	_FRAGMENT	denotes	control of
T8120	30670-30681	GO:0006417	denotes	translation
T8121	30650-30665	GO:0043631	denotes	polyadenylation
T8122	30689-30696	NCBITaxon:8353	denotes	Xenopus
T8123	30697-30703	CL:0000023	denotes	oocyte
T8124	30826-30836	NCBITaxon:7742	denotes	vertebrate
T8125	30837-30842	PR:000016008	denotes	TACC3
T8126	30870-30875	PR:000006990	denotes	eIF4E
T8127	30876-30880	PR:000005805	denotes	CPEB
T8128	30881-30888	GO:0032991	denotes	complex
T8129	30894-30899	NCBITaxon:9606	denotes	human
T8130	30907-30914	SO:0001060	denotes	isoform
T8131	30946-30951	PR:000006990	denotes	eIF4E
T8132	30952-30956	PR:000005805	denotes	CPEB
T8133	30957-30964	GO:0032991	denotes	complex
T8134	30980-30985	PR:000016006	denotes	TACC1
T8135	30986-30994	SO:0001060	denotes	isoforms
T8136	31086-31098	GO:0008380	denotes	RNA splicing
T8137	31086-31089	_FRAGMENT	denotes	RNA
T8138	31103-31112	GO:0050658	denotes	transport
T8139	31295-31300	NCBITaxon:9606	denotes	human
T8140	31357-31362	UBERON:0000955	denotes	brain
T8141	31427-31434	PR:000043452	denotes	histone
T8142	31427-31434	CHEBI:15358	denotes	histone
T8143	31453-31460	PR:Q92830	denotes	hGCN5L2
T8144	31493-31500	SO:0001060	denotes	isoform
T8145	31504-31512	CHEBI:26537	denotes	retinoid
T8146	31504-31525	PR:000014373	denotes	retinoid-X receptor β
T8147	31568-31574	SO:0000417	denotes	domain
T8148	31578-31583	PR:000016007	denotes	TACC2
T8149	31686-31690	PR:000014373	denotes	RXRβ
T8150	31725-31732	GO:0005634	denotes	nuclear
T8151	31751-31757	PR:Q965W2	denotes	nhr-86
T8152	31764-31774	NCBITaxon:6239	denotes	C. elegans
T8153	31823-31828	PR:P34427	denotes	lin36
T8154	31865-31875	NCBITaxon:33317	denotes	protostome
T8155	31975-31984	NCBITaxon:1	denotes	organisms
T8156	32174-32181	SO:0000417	denotes	domains
T8157	32205-32213	NCBITaxon:7711	denotes	chordate
T8158	32274-32284	NCBITaxon:7742	denotes	vertebrate
T8159	32380-32384	PR:000004303	denotes	ARNT
T8160	32442-32454	NCBITaxon:33511	denotes	deuterostome
T8161	32490-32495	PR:000017527	denotes	GAS41
T8162	32533-32538	NCBITaxon:9606	denotes	human
T8163	32539-32575	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T8164	32547-32567	GO:0006338	denotes	chromatin remodeling
T8165	32604-32619	NCBITaxon:7227	denotes	D. melanogaster
T8166	32620-32629	SO:0000853	denotes	homologue
T8167	32633-32638	PR:000017527	denotes	GAS41
T8168	32797-32810	SO:0000657	denotes	repeat region
T8169	32818-32828	NCBITaxon:7215	denotes	Drosophila
T8170	32874-32884	NCBITaxon:7742	denotes	vertebrate
T8171	32964-32974	GO:0065007	denotes	regulatory
T8172	32975-32984	GO:0032991	denotes	complexes
T8173	32995-33003	GO:0030674	denotes	bridging
T8174	33098-33104	SO:0000417	denotes	domain
T8175	33161-33172	NCBITaxon:33317	denotes	protostomes
T8176	33177-33190	NCBITaxon:33511	denotes	deuterostomes
T8177	33240-33248	GO:0030674	denotes	bridging
T8178	33271-33277	PR:Q27365	denotes	lin15A
T8179	33279-33284	PR:P34427	denotes	lin36
T8180	33288-33293	PR:000009822	denotes	lin37
T8181	33333-33339	PR:Q27365	denotes	lin15A
T8182	33341-33346	PR:P34427	denotes	lin36
T8183	33351-33356	PR:000009822	denotes	lin37
T8184	33357-33367	SO:0000853	denotes	homologues
T8185	33378-33387	NCBITaxon:1	denotes	organisms
T8186	33471-33478	GO:0032991	denotes	complex
T8187	33510-33516	SO:0001026	denotes	genome
T12458	1692-1697	PR:000001856	denotes	RHAMM
T12565	11291-11297	SO:0000987	denotes	Linear
T12566	11314-11318	SO:0000704	denotes	gene
T12567	11376-11381	SO:0000704	denotes	genes
T12568	11385-11391	NCBITaxon:9606	denotes	humans
T12569	11393-11403	SO:0000859	denotes	Paralogous
T12570	11404-11409	SO:0000704	denotes	genes
T12571	11503-11507	PR:000008212	denotes	GPX3
T12572	11512-11517	PR:000011245	denotes	NKX2E
T12573	11586-11591	SO:0000704	denotes	genes
T12574	11653-11658	SO:0000704	denotes	genes
T12575	11694-11702	_FRAGMENT	denotes	syntenic
T12576	11721-11728	SO:0005858	denotes	regions
T12577	11703-11708	NCBITaxon:10088	denotes	mouse
T12578	11750-11767	NCBITaxon:31033	denotes	Takifugu rubripes
T12579	11768-11777	SO:0001248	denotes	scaffolds
T12580	11821-11831	SO:0000857	denotes	homologous
T12581	11832-11836	SO:0000704	denotes	gene
T12582	11893-11903	SO:0000859	denotes	paralogous
T12583	11904-11909	SO:0000704	denotes	genes
T12757	15923-15940	NCBITaxon:31033	denotes	Takifugu rubripes
T12758	15945-15963	NCBITaxon:7719	denotes	Ciona intestinalis
T12759	15987-15994	SO:0001026	denotes	genomic
T12760	15995-16004	SO:0001248	denotes	scaffolds
T12761	16020-16037	NCBITaxon:31033	denotes	Takifugu rubripes
T12762	16060-16065	SO:0000704	denotes	genes
T12763	16067-16075	SO:0001248	denotes	Scaffold
T12764	16106-16110	SO:0000704	denotes	gene
T12765	16120-16125	SO:0000704	denotes	genes
T12766	16144-16154	SO:0000853	denotes	homologues
T12767	16158-16169	SO:0000855	denotes	orthologues
T12768	16189-16195	_FRAGMENT	denotes	arm of
T12769	16202-16212	SO:0000105	denotes	chromosome
T12770	16196-16201	NCBITaxon:9606	denotes	human
T12771	16231-16239	SO:0001248	denotes	scaffold
T12772	16327-16332	PR:000016006	denotes	TACC1
T12773	16333-16338	PR:000016007	denotes	TACC2
T12774	16381-16389	SO:0001248	denotes	scaffold
T12775	16410-16421	SO:0000855	denotes	orthologues
T12776	16425-16430	SO:0000704	denotes	genes
T12777	16459-16465	_FRAGMENT	denotes	arm of
T12778	16472-16482	SO:0000105	denotes	chromosome
T12779	16466-16471	NCBITaxon:9606	denotes	human
T12780	16491-16509	NCBITaxon:7719	denotes	Ciona intestinalis
T12781	16530-16535	SO:0000704	denotes	genes
T12782	16545-16564	SO:0000854	denotes	paralogous segments
T12783	16568-16573	NCBITaxon:9606	denotes	human
T12956	16605-16612	SO:0001026	denotes	Genomic
T12957	16635-16640	SO:0000704	denotes	genes
T12958	16697-16702	NCBITaxon:9606	denotes	human
T12959	16746-16751	NCBITaxon:9606	denotes	human
T12960	16752-16757	PR:000016006	denotes	TACC1
T12961	16777-16782	PR:000017527	denotes	GAS41
T12962	16821-16827	SO:0000417	denotes	domain
T12963	16834-16840	PR:000005512	denotes	ch-TOG
T12964	16860-16874	PR:000035365	denotes	Aurora kinases
T12965	16882-16889	NCBITaxon:species	denotes	species
T12966	16959-16964	SO:0000147	denotes	exons
T12967	16977-16982	SO:0000704	denotes	genes
T12968	17008-17015	SO:0001060	denotes	isoform
T12969	17025-17029	SO:0000704	denotes	gene
T13128	22576-22596	GO:0000380	denotes	Alternative splicing
T13129	22604-22609	NCBITaxon:9606	denotes	human
T13130	22610-22615	PR:000016006	denotes	TACC1
T13131	22616-22620	SO:0000704	denotes	gene
T13132	22633-22639	GO:0008380	denotes	splice
T13133	22674-22679	NCBITaxon:9606	denotes	human
T13134	22680-22685	PR:000016006	denotes	TACC1
T13135	22734-22740	GO:0008380	denotes	splice
T13136	22802-22807	NCBITaxon:9606	denotes	human
T13137	22808-22813	UBERON:0000955	denotes	brain
T13138	22824-22844	GO:0000380	denotes	Alternative splicing
T13139	22848-22853	PR:000016006	denotes	TACC1
T13140	22861-22866	NCBITaxon:9606	denotes	human
T13141	22867-22872	UBERON:0000955	denotes	brain
T13142	22899-22907	GO:0008380	denotes	splicing
T13143	22915-22932	SO:0000198	denotes	untranslated exon
T13144	22917-22927	GO:0006412	denotes	translated
T13145	22939-22943	SO:0000147	denotes	exon
T13146	23049-23053	SO:0000147	denotes	Exon
T13147	23062-23069	GO:0008380	denotes	splices
T13148	23073-23077	SO:0000147	denotes	exon
T13149	23094-23099	PR:000009965	denotes	L-Sm7
T13150	23180-23185	SO:0000147	denotes	exons
T13151	23252-23259	GO:0005634	denotes	nuclear
T13152	23252-23280	SO:0001528	denotes	nuclear localization signals
T13153	23298-23305	SO:0000417	denotes	domains
T13154	23310-23315	PR:000017527	denotes	GAS41
T13155	23320-23330	PR:000029784	denotes	PCTAIRE2BP
T13156	23369-23375	SO:0000417	denotes	domain
T13157	23416-23422	PR:000005512	denotes	ch-TOG
T13158	23427-23442	PR:000004515	denotes	Aurora A kinase
T13159	23450-23460	GO:0005813	denotes	centrosome
T13564	26968-26978	NCBITaxon:6239	denotes	C. elegans
T13565	26983-26998	NCBITaxon:7227	denotes	D. melanogaster
T13566	27005-27015	NCBITaxon:6239	denotes	C. elegans
T13567	27228-27237	GO:0000785	denotes	chromatin
T13568	27228-27248	GO:0006338	denotes	chromatin remodeling
T13569	27249-27258	GO:0032991	denotes	complexes
T13570	27260-27267	GO:0016514	denotes	SWI/SNF
T13571	27272-27279	PR:000043452	denotes	histone
T13572	27272-27279	CHEBI:15358	denotes	histone
T13573	27301-27318	GO:0006281	denotes	DNA damage repair
T13574	27346-27358	GO:0008380	denotes	RNA splicing
T13575	27346-27349	_FRAGMENT	denotes	RNA
T13576	27360-27369	GO:0050658	denotes	transport
T13577	27374-27387	GO:0006412	denotes	translational
T13578	27434-27444	NCBITaxon:7742	denotes	vertebrate
T13579	27512-27519	GO:0005634	denotes	nuclear
T13580	27537-27541	PR:000014373	denotes	RXRβ
T13581	27682-27701	SO:0000854	denotes	paralogous segments
T13582	27803-27813	NCBITaxon:7742	denotes	Vertebrate
T13583	27908-27918	NCBITaxon:7742	denotes	vertebrate
T13584	27919-27928	SO:0000853	denotes	homologue
T13585	27992-28005	PR:000035365	denotes	Aurora kinase
T13853	33562-33568	PR:000016007	denotes	TACC2s
T13854	33603-33606	CHEBI:8984	denotes	SDS
T13855	33640-33650	GO:0006412	denotes	translated
T13856	33688-33693	PR:000016007	denotes	TACC2
T13857	33749-33759	GO:0006412	denotes	translated
T13858	33760-33765	PR:000014373	denotes	RXR-β
T13859	33878-33883	PR:000016007	denotes	TACC2
T12454	1413-1424	SO:0001080	denotes	coiled coil
T12455	1558-1569	SO:0001080	denotes	coiled coil
T12456	1611-1622	SO:0001080	denotes	coiled coil
T12457	1654-1659	PR:000001856	denotes	RHAMM
T6962	25865-25871	GO:0030674	denotes	bridge
T6963	25903-25915	GO:0005856	denotes	cytoskeleton
T6964	25920-25931	GO:0005874	denotes	microtubule
T6965	25973-25981	GO:0005840	denotes	ribosome
T6966	25987-25994	PR:000043452	denotes	histone
T6967	25987-25994	CHEBI:15358	denotes	histone
T6968	26007-26016	GO:0000785	denotes	chromatin
T6969	26007-26027	GO:0006338	denotes	chromatin remodeling
T6970	26046-26051	PR:000006937	denotes	egr-1
T6971	26056-26062	PR:P90916	denotes	lin-53
T6972	26068-26078	NCBITaxon:6239	denotes	C. elegans
T6973	26079-26089	SO:0000853	denotes	homologues
T6974	26097-26102	NCBITaxon:9606	denotes	human
T6975	26103-26108	PR:000010707	denotes	MTA-1
T6976	26113-26119	PR:000013776	denotes	RbAP48
T6977	26163-26167	PR:P34766	denotes	PAL1
T6978	26185-26192	GO:0005634	denotes	nuclear
T6979	26210-26216	PR:Q965W2	denotes	nhr-86
T6980	26287-26297	NCBITaxon:7215	denotes	Drosophila
T6981	26413-26423	NCBITaxon:7215	denotes	Drosophila
T6982	26424-26460	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T6983	26432-26452	GO:0006338	denotes	chromatin remodeling
T1333	749-766	NCBITaxon:7165	denotes	Anopheles gambiae
T1334	836-841	SO:0000704	denotes	genes
T1335	845-853	NCBITaxon:33208	denotes	metazoan
T1336	913-919	SO:0001026	denotes	genome
T1421	4698-4703	NCBITaxon:10088	denotes	mouse
T1422	4780-4800	SO:0000043	denotes	processed pseudogene
T1423	4813-4818	PR:000016006	denotes	TACC1
T1424	4819-4830	SO:0000336	denotes	pseudogenes
T1425	4889-4894	NCBITaxon:9606	denotes	human
T1426	4971-4973	SO:0000028	denotes	bp
T1427	4981-4986	PR:000016006	denotes	TACC1
T1428	4987-5009	SO:0000205	denotes	3' untranslated region
T1429	4992-5002	GO:0006412	denotes	translated
T1430	5014-5025	SO:0000336	denotes	pseudogenes
T1431	5043-5048	PR:000016007	denotes	TACC2
T1432	5052-5057	PR:000016008	denotes	TACC3
T1433	5081-5090	NCBITaxon:40674	denotes	mammalian
T1434	5091-5098	NCBITaxon:species	denotes	species
T3801	9763-9768	SO:0000704	denotes	genes
T3802	9803-9808	SO:0000704	denotes	genes
T3803	9839-9849	NCBITaxon:7742	denotes	vertebrate
T3804	9850-9855	PR:000016006	denotes	TACC1
T3805	9858-9863	SO:0000704	denotes	genes
T3860	12687-12694	SO:0001026	denotes	genomic
T3861	12695-12703	SO:0001248	denotes	scaffold
T3862	12755-12760	NCBITaxon:9606	denotes	human
T3863	12761-12772	SO:0000855	denotes	orthologues
R8156	T12576	T12575	_lexicallyChainedTo	regions,syntenic
R8278	T12769	T12768	_lexicallyChainedTo	chromosome,arm of
R2434	T3812	T3811	_lexicallyChainedTo	segments,paralogous
R2435	T3819	T3818	_lexicallyChainedTo	segments,paralogous
R2436	T3908	T3907	_lexicallyChainedTo	segment,paralogous
R2437	T3914	T3913	_lexicallyChainedTo	segments,paralogous
R4060	T6249	T6248	_lexicallyChainedTo	organism,development of
R4061	T6299	T6298	_lexicallyChainedTo	metabolism,cellular
R4424	T6960	T6959	_lexicallyChainedTo	lin36,C. elegans
R5171	T8117	T8116	_lexicallyChainedTo	protein,binding site for
R5172	T8120	T8119	_lexicallyChainedTo	translation,control of
R5173	T8138	T8137	_lexicallyChainedTo	transport,RNA
R8279	T12778	T12777	_lexicallyChainedTo	chromosome,arm of
R8789	T13576	T13575	_lexicallyChainedTo	transport,RNA

2_test

Id	Subject	Object	Predicate	Lexical cue
15207008-12481130-9665992	1959-1961	12481130	denotes	11
15207008-11752271-9665993	2050-2052	11752271	denotes	12
15207008-12015314-9665994	5840-5841	12015314	denotes	9
15207008-12015314-9665995	6028-6029	12015314	denotes	9
15207008-10366448-9665996	6498-6499	10366448	denotes	2
15207008-12015314-9665997	6890-6891	12015314	denotes	9
15207008-12015314-9665998	7156-7157	12015314	denotes	9
15207008-12808028-9665999	8436-8438	12808028	denotes	10
15207008-12777526-9666000	10102-10104	12777526	denotes	13
15207008-12808028-9666001	10891-10893	12808028	denotes	10
15207008-12481130-9666002	12177-12179	12481130	denotes	11
15207008-12142439-9666003	12264-12266	12142439	denotes	14
15207008-12481130-9666004	14604-14606	12481130	denotes	11
15207008-11903063-9666005	18795-18797	11903063	denotes	15
15207008-11756182-9666006	18798-18800	11756182	denotes	16
15207008-10366448-9666007	19591-19592	10366448	denotes	2
15207008-10366448-9666008	20028-20029	10366448	denotes	2
15207008-11025203-9666009	20030-20031	11025203	denotes	7
15207008-12237944-9666010	20032-20034	12237944	denotes	17
15207008-11025203-9666011	20305-20306	11025203	denotes	7
15207008-10635326-9666012	20587-20588	10635326	denotes	8
15207008-12620397-9666013	21218-21219	12620397	denotes	3
15207008-12620397-9666014	21350-21351	12620397	denotes	3
15207008-12547166-9666015	21641-21643	12547166	denotes	18
15207008-12165861-9666016	21644-21646	12165861	denotes	19
15207008-14603251-9666017	21928-21930	14603251	denotes	20
15207008-11903063-9666018	22022-22024	11903063	denotes	15
15207008-14603251-9666019	22042-22044	14603251	denotes	20
15207008-12165861-9666020	22138-22140	12165861	denotes	19
15207008-12547166-9666021	22561-22563	12547166	denotes	18
15207008-14602875-9666022	24328-24330	14602875	denotes	21
15207008-12956952-9666023	24500-24501	12956952	denotes	5
15207008-12956951-9666024	24502-24503	12956951	denotes	6
15207008-12970190-9666025	24504-24506	12970190	denotes	22
15207008-12569123-9666025	24504-24506	12569123	denotes	22
15207008-11433296-9666025	24504-24506	11433296	denotes	22
15207008-14603251-9666026	24541-24543	14603251	denotes	20
15207008-14602875-9666027	24544-24546	14602875	denotes	21
15207008-11827981-9666028	24547-24549	11827981	denotes	25
15207008-12956952-9666029	24672-24673	12956952	denotes	5
15207008-12956951-9666030	24674-24675	12956951	denotes	6
15207008-12970190-9666031	24676-24678	12970190	denotes	22
15207008-12569123-9666031	24676-24678	12569123	denotes	22
15207008-11433296-9666031	24676-24678	11433296	denotes	22
15207008-14602875-9666032	25060-25062	14602875	denotes	21
15207008-11903063-9666033	25291-25293	11903063	denotes	15
15207008-12711550-9666034	25294-25296	12711550	denotes	26
15207008-11121038-9666035	25297-25299	11121038	denotes	27
15207008-10615043-9666036	25845-25847	10615043	denotes	28
15207008-10615043-9666037	26218-26220	10615043	denotes	28
15207008-12519993-9666038	26268-26270	12519993	denotes	29
15207008-14711411-9666039	26644-26646	14711411	denotes	30
15207008-7745706-9666040	28816-28818	7745706	denotes	31
15207008-14667816-9666041	28819-28821	14667816	denotes	32
15207008-12620397-9666042	29643-29644	12620397	denotes	3
15207008-12956952-9666043	29645-29646	12956952	denotes	5
15207008-12956951-9666043	29645-29646	12956951	denotes	5
15207008-11025203-9666043	29645-29646	11025203	denotes	5
15207008-11903063-9666044	29649-29651	11903063	denotes	15
15207008-12165861-9666045	29652-29654	12165861	denotes	19
15207008-14603251-9666045	29652-29654	14603251	denotes	19
15207008-14602875-9666045	29652-29654	14602875	denotes	19
15207008-11433296-9666046	29658-29660	11433296	denotes	24
15207008-11827981-9666047	29661-29663	11827981	denotes	25
15207008-11847113-9666048	29664-29666	11847113	denotes	33
15207008-14767476-9666049	29667-29669	14767476	denotes	34
15207008-12956952-9666050	29986-29987	12956952	denotes	5
15207008-12956951-9666051	29988-29989	12956951	denotes	6
15207008-14602875-9666052	29990-29992	14602875	denotes	21
15207008-12970190-9666052	29990-29992	12970190	denotes	21
15207008-12569123-9666052	29990-29992	12569123	denotes	21
15207008-11433296-9666052	29990-29992	11433296	denotes	21
15207008-11121038-9666053	30173-30175	11121038	denotes	27
15207008-14602875-9666054	30313-30315	14602875	denotes	21
15207008-10635326-9666055	30705-30706	10635326	denotes	8
15207008-11081630-9666056	30707-30709	11081630	denotes	35
15207008-12165861-9666057	31124-31126	12165861	denotes	19
15207008-12620397-9666058	31316-31317	12620397	denotes	3
15207008-14767476-9666059	31318-31320	14767476	denotes	34
15207008-14767476-9666060	31462-31464	14767476	denotes	34
15207008-11025203-9666061	32407-32408	11025203	denotes	7
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PMC:441373 / 4891-38783 JSONTXT

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craft-sa-dev

craft-ca-core-ex-dev

craft-ca-core-dev

2_test

PMC:441373 / 4891-38783 JSON TXT