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order to examine evolutionary relationships of proteins containing coiled coil domains, protein sequences representing the major members of this super family, including TACC, RHAMM, KLP, keratin and tropomyosin from available vertebrates and their recognizable orthologues from the urochordate Ciona intestinalis, Drosophila melanogaster, C. elegans and Saccharomyces cerevisiae were either directly retrieved from NCBI sequence databases, newly predicted or isolated (see above). Species abbreviations are as follows: hs (Homo sapiens), mm (Mus musculus), rn (Rattus norvegus), oc (Oryctolagus cuniculus), gg (Gallus gallus), xl (Xenopus laevis), st (Silurana tropicalis), tr (Takifugu rubripes), dr (Danio rerio), ci (Ciona intestinalis), dm (D. melanogaster), ce (C. elegans), sc (Saccharomyces cerevisiae). The sequences identified above and the following protein or predicted translations were used for phylogenetic analysis: hsTACC1A (NP_006274), hsTACC2l (AAO62630) hsTACC2s (AAO62629), hsTACC3 (NP_006333), mmTACC3 (Q9JJ11), xlMaskin (Q9PTG8), dmTACC (AAF52099), ceTAC1 (NP_497059), scSPC72 (NP_009352), hsRHAMM (NP_036616), mmRHAMM (NP_038580), rnRHAMM (NP_037096), drRHAMM (AAQ97980), hsKeratin (CAB76828), mmKeratin (A61368), rnKeratin (XP_235679), hsTPM1 (NP_000357), mmTPM1 (NP_077745), rnTPM1 (NP_62004, drTPM1 (NP_571180) dmTPM1 (P06754), ceTPM (NP_493540) scTPM1 (P17536), hsKLP2 (BAB03309), rnKIF15 (AAP44513), xlKLP2 (CAA08879), dmKLP2 (NP_476818), ceKLP18 (AA034669), hsKIF3A (Q9Y496), mmKIF3A (NP_032469), rnKIF3A (XP_340797), xlKIF3A (CAA08879), ceKLP11 (NP_741473), ciKIF3 (ci0100148992), hsKIF3B (NP_004789), mmKIF3B (NP_004789), rnKIF3B (XP_215883), dmKIF3B (NP_524029), hsKIF3C (NP_002245), mmKIF3C (NP_032471), rnKIF3C (NP_445938), dmKIF3C (NP_651939)."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T11361","span":{"begin":50,"end":58},"obj":"CHEBI_PR_EXT:protein"},{"id":"T11362","span":{"begin":70,"end":81},"obj":"SO_EXT:0001080"},{"id":"T11363","span":{"begin":82,"end":89},"obj":"SO_EXT:0000417"},{"id":"T11364","span":{"begin":91,"end":98},"obj":"CHEBI_PR_EXT:protein"},{"id":"T11365","span":{"begin":99,"end":108},"obj":"SO_EXT:biological_sequence"},{"id":"T11366","span":{"begin":178,"end":183},"obj":"PR_EXT:000001856"},{"id":"T11367","span":{"begin":229,"end":240},"obj":"NCBITaxon:7742"},{"id":"T11368","span":{"begin":264,"end":275},"obj":"SO_EXT:0000855"},{"id":"T11369","span":{"begin":285,"end":296},"obj":"NCBITaxon:7712"},{"id":"T11370","span":{"begin":297,"end":315},"obj":"NCBITaxon:7719"},{"id":"T11371","span":{"begin":317,"end":340},"obj":"NCBITaxon:7227"},{"id":"T11372","span":{"begin":342,"end":352},"obj":"NCBITaxon:6239"},{"id":"T11373","span":{"begin":357,"end":381},"obj":"NCBITaxon:4932"},{"id":"T11374","span":{"begin":423,"end":431},"obj":"SO_EXT:biological_sequence"},{"id":"T11375","span":{"begin":484,"end":491},"obj":"NCBITaxon:species"},{"id":"T11376","span":{"begin":522,"end":524},"obj":"NCBITaxon:9606"},{"id":"T11377","span":{"begin":526,"end":538},"obj":"NCBITaxon:9606"},{"id":"T11378","span":{"begin":541,"end":543},"obj":"NCBITaxon:10090"},{"id":"T11379","span":{"begin":545,"end":557},"obj":"NCBITaxon:10090"},{"id":"T11380","span":{"begin":560,"end":562},"obj":"NCBITaxon:10116"},{"id":"T11381","span":{"begin":564,"end":579},"obj":"NCBITaxon:10116"},{"id":"T11382","span":{"begin":582,"end":584},"obj":"NCBITaxon:9986"},{"id":"T11383","span":{"begin":586,"end":607},"obj":"NCBITaxon:9986"},{"id":"T11384","span":{"begin":610,"end":612},"obj":"NCBITaxon:9031"},{"id":"T11385","span":{"begin":614,"end":627},"obj":"NCBITaxon:9031"},{"id":"T11386","span":{"begin":630,"end":632},"obj":"NCBITaxon:8355"},{"id":"T11387","span":{"begin":634,"end":648},"obj":"NCBITaxon:8355"},{"id":"T11388","span":{"begin":651,"end":653},"obj":"NCBITaxon:8364"},{"id":"T11389","span":{"begin":655,"end":674},"obj":"NCBITaxon:8364"},{"id":"T11390","span":{"begin":677,"end":679},"obj":"NCBITaxon:31033"},{"id":"T11391","span":{"begin":681,"end":698},"obj":"NCBITaxon:31033"},{"id":"T11392","span":{"begin":701,"end":703},"obj":"NCBITaxon:7955"},{"id":"T11393","span":{"begin":705,"end":716},"obj":"NCBITaxon:7955"},{"id":"T11394","span":{"begin":719,"end":721},"obj":"NCBITaxon:7719"},{"id":"T11395","span":{"begin":723,"end":741},"obj":"NCBITaxon:7719"},{"id":"T11396","span":{"begin":744,"end":746},"obj":"NCBITaxon:7227"},{"id":"T11397","span":{"begin":748,"end":763},"obj":"NCBITaxon:7227"},{"id":"T11398","span":{"begin":766,"end":768},"obj":"NCBITaxon:6239"},{"id":"T11399","span":{"begin":770,"end":780},"obj":"NCBITaxon:6239"},{"id":"T11400","span":{"begin":783,"end":785},"obj":"NCBITaxon:4932"},{"id":"T11401","span":{"begin":787,"end":811},"obj":"NCBITaxon:4932"},{"id":"T11402","span":{"begin":818,"end":827},"obj":"SO_EXT:biological_sequence"},{"id":"T11403","span":{"begin":863,"end":870},"obj":"CHEBI_PR_EXT:protein"},{"id":"T11404","span":{"begin":934,"end":942},"obj":"PR_EXT:O75410-1"},{"id":"T11405","span":{"begin":956,"end":964},"obj":"PR_EXT:O95359-4"},{"id":"T11406","span":{"begin":976,"end":984},"obj":"PR_EXT:O95359-1"},{"id":"T11407","span":{"begin":997,"end":1004},"obj":"PR_EXT:Q9Y6A5"},{"id":"T11408","span":{"begin":1018,"end":1025},"obj":"PR_EXT:Q9JJ11"},{"id":"T11409","span":{"begin":1094,"end":1101},"obj":"PR_EXT:P39723"},{"id":"T11410","span":{"begin":1115,"end":1122},"obj":"PR_EXT:O75330"},{"id":"T11411","span":{"begin":1136,"end":1143},"obj":"PR_EXT:Q00547"},{"id":"T11412","span":{"begin":1157,"end":1164},"obj":"PR_EXT:P97779"},{"id":"T11413","span":{"begin":1178,"end":1185},"obj":"PR_EXT:Q9W3V2"},{"id":"T11414","span":{"begin":1263,"end":1269},"obj":"PR_EXT:P09493"},{"id":"T11415","span":{"begin":1283,"end":1289},"obj":"PR_EXT:P58771"},{"id":"T11416","span":{"begin":1303,"end":1309},"obj":"PR_EXT:P04692"},{"id":"T11417","span":{"begin":1321,"end":1327},"obj":"PR_EXT:P13104"},{"id":"T11418","span":{"begin":1375,"end":1381},"obj":"PR_EXT:P17536"},{"id":"T11419","span":{"begin":1392,"end":1398},"obj":"PR_EXT:Q9NS87"},{"id":"T11420","span":{"begin":1411,"end":1418},"obj":"PR_EXT:Q7TSP2"},{"id":"T11421","span":{"begin":1450,"end":1456},"obj":"PR_EXT:P46863"},{"id":"T11422","span":{"begin":1490,"end":1497},"obj":"PR_EXT:Q9Y496"},{"id":"T11423","span":{"begin":1508,"end":1515},"obj":"PR_EXT:P28741"},{"id":"T11424","span":{"begin":1614,"end":1621},"obj":"PR_EXT:O15066"},{"id":"T11425","span":{"begin":1635,"end":1642},"obj":"PR_EXT:Q61771"},{"id":"T11426","span":{"begin":1677,"end":1684},"obj":"PR_EXT:P46867"},{"id":"T11427","span":{"begin":1698,"end":1705},"obj":"PR_EXT:O14782"},{"id":"T11428","span":{"begin":1719,"end":1726},"obj":"PR_EXT:O35066"},{"id":"T11429","span":{"begin":1740,"end":1747},"obj":"PR_EXT:O55165"}],"text":"In order to examine evolutionary relationships of proteins containing coiled coil domains, protein sequences representing the major members of this super family, including TACC, RHAMM, KLP, keratin and tropomyosin from available vertebrates and their recognizable orthologues from the urochordate Ciona intestinalis, Drosophila melanogaster, C. elegans and Saccharomyces cerevisiae were either directly retrieved from NCBI sequence databases, newly predicted or isolated (see above). Species abbreviations are as follows: hs (Homo sapiens), mm (Mus musculus), rn (Rattus norvegus), oc (Oryctolagus cuniculus), gg (Gallus gallus), xl (Xenopus laevis), st (Silurana tropicalis), tr (Takifugu rubripes), dr (Danio rerio), ci (Ciona intestinalis), dm (D. melanogaster), ce (C. elegans), sc (Saccharomyces cerevisiae). The sequences identified above and the following protein or predicted translations were used for phylogenetic analysis: hsTACC1A (NP_006274), hsTACC2l (AAO62630) hsTACC2s (AAO62629), hsTACC3 (NP_006333), mmTACC3 (Q9JJ11), xlMaskin (Q9PTG8), dmTACC (AAF52099), ceTAC1 (NP_497059), scSPC72 (NP_009352), hsRHAMM (NP_036616), mmRHAMM (NP_038580), rnRHAMM (NP_037096), drRHAMM (AAQ97980), hsKeratin (CAB76828), mmKeratin (A61368), rnKeratin (XP_235679), hsTPM1 (NP_000357), mmTPM1 (NP_077745), rnTPM1 (NP_62004, drTPM1 (NP_571180) dmTPM1 (P06754), ceTPM (NP_493540) scTPM1 (P17536), hsKLP2 (BAB03309), rnKIF15 (AAP44513), xlKLP2 (CAA08879), dmKLP2 (NP_476818), ceKLP18 (AA034669), hsKIF3A (Q9Y496), mmKIF3A (NP_032469), rnKIF3A (XP_340797), xlKIF3A (CAA08879), ceKLP11 (NP_741473), ciKIF3 (ci0100148992), hsKIF3B (NP_004789), mmKIF3B (NP_004789), rnKIF3B (XP_215883), dmKIF3B (NP_524029), hsKIF3C (NP_002245), mmKIF3C (NP_032471), rnKIF3C (NP_445938), dmKIF3C (NP_651939)."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T11298","span":{"begin":70,"end":81},"obj":"SO:0001080"},{"id":"T11299","span":{"begin":82,"end":89},"obj":"SO:0000417"},{"id":"T11300","span":{"begin":178,"end":183},"obj":"PR:000001856"},{"id":"T11301","span":{"begin":229,"end":240},"obj":"NCBITaxon:7742"},{"id":"T11302","span":{"begin":264,"end":275},"obj":"SO:0000855"},{"id":"T11303","span":{"begin":285,"end":296},"obj":"NCBITaxon:7712"},{"id":"T11304","span":{"begin":297,"end":315},"obj":"NCBITaxon:7719"},{"id":"T11305","span":{"begin":317,"end":340},"obj":"NCBITaxon:7227"},{"id":"T11306","span":{"begin":342,"end":352},"obj":"NCBITaxon:6239"},{"id":"T11307","span":{"begin":357,"end":381},"obj":"NCBITaxon:4932"},{"id":"T11308","span":{"begin":484,"end":491},"obj":"NCBITaxon:species"},{"id":"T11309","span":{"begin":522,"end":524},"obj":"NCBITaxon:9606"},{"id":"T11310","span":{"begin":526,"end":538},"obj":"NCBITaxon:9606"},{"id":"T11311","span":{"begin":541,"end":543},"obj":"NCBITaxon:10090"},{"id":"T11312","span":{"begin":545,"end":557},"obj":"NCBITaxon:10090"},{"id":"T11313","span":{"begin":560,"end":562},"obj":"NCBITaxon:10116"},{"id":"T11314","span":{"begin":564,"end":579},"obj":"NCBITaxon:10116"},{"id":"T11315","span":{"begin":582,"end":584},"obj":"NCBITaxon:9986"},{"id":"T11316","span":{"begin":586,"end":607},"obj":"NCBITaxon:9986"},{"id":"T11317","span":{"begin":610,"end":612},"obj":"NCBITaxon:9031"},{"id":"T11318","span":{"begin":614,"end":627},"obj":"NCBITaxon:9031"},{"id":"T11319","span":{"begin":630,"end":632},"obj":"NCBITaxon:8355"},{"id":"T11320","span":{"begin":634,"end":648},"obj":"NCBITaxon:8355"},{"id":"T11321","span":{"begin":651,"end":653},"obj":"NCBITaxon:8364"},{"id":"T11322","span":{"begin":655,"end":674},"obj":"NCBITaxon:8364"},{"id":"T11323","span":{"begin":677,"end":679},"obj":"NCBITaxon:31033"},{"id":"T11324","span":{"begin":681,"end":698},"obj":"NCBITaxon:31033"},{"id":"T11325","span":{"begin":701,"end":703},"obj":"NCBITaxon:7955"},{"id":"T11326","span":{"begin":705,"end":716},"obj":"NCBITaxon:7955"},{"id":"T11327","span":{"begin":719,"end":721},"obj":"NCBITaxon:7719"},{"id":"T11328","span":{"begin":723,"end":741},"obj":"NCBITaxon:7719"},{"id":"T11329","span":{"begin":744,"end":746},"obj":"NCBITaxon:7227"},{"id":"T11330","span":{"begin":748,"end":763},"obj":"NCBITaxon:7227"},{"id":"T11331","span":{"begin":766,"end":768},"obj":"NCBITaxon:6239"},{"id":"T11332","span":{"begin":770,"end":780},"obj":"NCBITaxon:6239"},{"id":"T11333","span":{"begin":783,"end":785},"obj":"NCBITaxon:4932"},{"id":"T11334","span":{"begin":787,"end":811},"obj":"NCBITaxon:4932"},{"id":"T11335","span":{"begin":934,"end":942},"obj":"PR:O75410-1"},{"id":"T11336","span":{"begin":956,"end":964},"obj":"PR:O95359-4"},{"id":"T11337","span":{"begin":976,"end":984},"obj":"PR:O95359-1"},{"id":"T11338","span":{"begin":997,"end":1004},"obj":"PR:Q9Y6A5"},{"id":"T11339","span":{"begin":1018,"end":1025},"obj":"PR:Q9JJ11"},{"id":"T11340","span":{"begin":1094,"end":1101},"obj":"PR:P39723"},{"id":"T11341","span":{"begin":1115,"end":1122},"obj":"PR:O75330"},{"id":"T11342","span":{"begin":1136,"end":1143},"obj":"PR:Q00547"},{"id":"T11343","span":{"begin":1157,"end":1164},"obj":"PR:P97779"},{"id":"T11344","span":{"begin":1178,"end":1185},"obj":"PR:Q9W3V2"},{"id":"T11345","span":{"begin":1263,"end":1269},"obj":"PR:P09493"},{"id":"T11346","span":{"begin":1283,"end":1289},"obj":"PR:P58771"},{"id":"T11347","span":{"begin":1303,"end":1309},"obj":"PR:P04692"},{"id":"T11348","span":{"begin":1321,"end":1327},"obj":"PR:P13104"},{"id":"T11349","span":{"begin":1375,"end":1381},"obj":"PR:P17536"},{"id":"T11350","span":{"begin":1392,"end":1398},"obj":"PR:Q9NS87"},{"id":"T11351","span":{"begin":1411,"end":1418},"obj":"PR:Q7TSP2"},{"id":"T11352","span":{"begin":1450,"end":1456},"obj":"PR:P46863"},{"id":"T11353","span":{"begin":1490,"end":1497},"obj":"PR:Q9Y496"},{"id":"T11354","span":{"begin":1508,"end":1515},"obj":"PR:P28741"},{"id":"T11355","span":{"begin":1614,"end":1621},"obj":"PR:O15066"},{"id":"T11356","span":{"begin":1635,"end":1642},"obj":"PR:Q61771"},{"id":"T11357","span":{"begin":1677,"end":1684},"obj":"PR:P46867"},{"id":"T11358","span":{"begin":1698,"end":1705},"obj":"PR:O14782"},{"id":"T11359","span":{"begin":1719,"end":1726},"obj":"PR:O35066"},{"id":"T11360","span":{"begin":1740,"end":1747},"obj":"PR:O55165"}],"text":"In order to examine evolutionary relationships of proteins containing coiled coil domains, protein sequences representing the major members of this super family, including TACC, RHAMM, KLP, keratin and tropomyosin from available vertebrates and their recognizable orthologues from the urochordate Ciona intestinalis, Drosophila melanogaster, C. elegans and Saccharomyces cerevisiae were either directly retrieved from NCBI sequence databases, newly predicted or isolated (see above). Species abbreviations are as follows: hs (Homo sapiens), mm (Mus musculus), rn (Rattus norvegus), oc (Oryctolagus cuniculus), gg (Gallus gallus), xl (Xenopus laevis), st (Silurana tropicalis), tr (Takifugu rubripes), dr (Danio rerio), ci (Ciona intestinalis), dm (D. melanogaster), ce (C. elegans), sc (Saccharomyces cerevisiae). The sequences identified above and the following protein or predicted translations were used for phylogenetic analysis: hsTACC1A (NP_006274), hsTACC2l (AAO62630) hsTACC2s (AAO62629), hsTACC3 (NP_006333), mmTACC3 (Q9JJ11), xlMaskin (Q9PTG8), dmTACC (AAF52099), ceTAC1 (NP_497059), scSPC72 (NP_009352), hsRHAMM (NP_036616), mmRHAMM (NP_038580), rnRHAMM (NP_037096), drRHAMM (AAQ97980), hsKeratin (CAB76828), mmKeratin (A61368), rnKeratin (XP_235679), hsTPM1 (NP_000357), mmTPM1 (NP_077745), rnTPM1 (NP_62004, drTPM1 (NP_571180) dmTPM1 (P06754), ceTPM (NP_493540) scTPM1 (P17536), hsKLP2 (BAB03309), rnKIF15 (AAP44513), xlKLP2 (CAA08879), dmKLP2 (NP_476818), ceKLP18 (AA034669), hsKIF3A (Q9Y496), mmKIF3A (NP_032469), rnKIF3A (XP_340797), xlKIF3A (CAA08879), ceKLP11 (NP_741473), ciKIF3 (ci0100148992), hsKIF3B (NP_004789), mmKIF3B (NP_004789), rnKIF3B (XP_215883), dmKIF3B (NP_524029), hsKIF3C (NP_002245), mmKIF3C (NP_032471), rnKIF3C (NP_445938), dmKIF3C (NP_651939)."}