Id |
Subject |
Object |
Predicate |
Lexical cue |
T9492 |
0-8 |
VBN |
denotes |
Proposed |
T9493 |
20-29 |
NN |
denotes |
evolution |
T9494 |
9-19 |
JJ |
denotes |
functional |
T9495 |
30-32 |
IN |
denotes |
of |
T9496 |
33-36 |
DT |
denotes |
the |
T9497 |
42-48 |
NN |
denotes |
family |
T9498 |
37-41 |
NN |
denotes |
TACC |
T9499 |
48-167 |
sentence |
denotes |
Examination of the evolution of ancient gene families provides an insight into how gene structure relates to function. |
T9500 |
49-60 |
NN |
denotes |
Examination |
T9501 |
103-111 |
VBZ |
denotes |
provides |
T9502 |
61-63 |
IN |
denotes |
of |
T9503 |
64-67 |
DT |
denotes |
the |
T9504 |
68-77 |
NN |
denotes |
evolution |
T9505 |
78-80 |
IN |
denotes |
of |
T9506 |
81-88 |
JJ |
denotes |
ancient |
T9507 |
94-102 |
NNS |
denotes |
families |
T9508 |
89-93 |
NN |
denotes |
gene |
T9509 |
112-114 |
DT |
denotes |
an |
T9510 |
115-122 |
NN |
denotes |
insight |
T9511 |
123-127 |
IN |
denotes |
into |
T9512 |
128-131 |
WRB |
denotes |
how |
T9513 |
147-154 |
VBZ |
denotes |
relates |
T9514 |
132-136 |
NN |
denotes |
gene |
T9515 |
137-146 |
NN |
denotes |
structure |
T9516 |
155-157 |
IN |
denotes |
to |
T9517 |
158-166 |
NN |
denotes |
function |
T9518 |
166-167 |
. |
denotes |
. |
T9519 |
167-240 |
sentence |
denotes |
We have presented above, a detailed examination of one such gene family. |
T9520 |
168-170 |
PRP |
denotes |
We |
T9521 |
176-185 |
VBN |
denotes |
presented |
T9522 |
171-175 |
VBP |
denotes |
have |
T9523 |
186-191 |
RB |
denotes |
above |
T9524 |
191-193 |
, |
denotes |
, |
T9525 |
193-194 |
DT |
denotes |
a |
T9526 |
204-215 |
NN |
denotes |
examination |
T9527 |
195-203 |
JJ |
denotes |
detailed |
T9528 |
216-218 |
IN |
denotes |
of |
T9529 |
219-222 |
CD |
denotes |
one |
T9530 |
233-239 |
NN |
denotes |
family |
T9531 |
223-227 |
JJ |
denotes |
such |
T9532 |
228-232 |
NN |
denotes |
gene |
T9533 |
239-240 |
. |
denotes |
. |
T9534 |
240-385 |
sentence |
denotes |
The data so far suggest that the functional TACC homologue in yeast (spc72) has a specific role in centrosomal/mitotic spindle dynamics [21,22]. |
T9535 |
241-244 |
DT |
denotes |
The |
T9536 |
245-249 |
NNS |
denotes |
data |
T9537 |
257-264 |
VBP |
denotes |
suggest |
T9538 |
250-252 |
RB |
denotes |
so |
T9539 |
253-256 |
RB |
denotes |
far |
T9540 |
265-269 |
IN |
denotes |
that |
T9541 |
317-320 |
VBZ |
denotes |
has |
T9542 |
270-273 |
DT |
denotes |
the |
T9543 |
290-299 |
NN |
denotes |
homologue |
T9544 |
274-284 |
JJ |
denotes |
functional |
T9545 |
285-289 |
NN |
denotes |
TACC |
T9546 |
300-302 |
IN |
denotes |
in |
T9547 |
303-308 |
NN |
denotes |
yeast |
T9548 |
309-310 |
-LRB- |
denotes |
( |
T9549 |
310-315 |
NN |
denotes |
spc72 |
T9550 |
315-316 |
-RRB- |
denotes |
) |
T9551 |
321-322 |
DT |
denotes |
a |
T9552 |
332-336 |
NN |
denotes |
role |
T9553 |
323-331 |
JJ |
denotes |
specific |
T9554 |
337-339 |
IN |
denotes |
in |
T9555 |
340-351 |
JJ |
denotes |
centrosomal |
T9556 |
352-359 |
JJ |
denotes |
mitotic |
T9557 |
351-352 |
HYPH |
denotes |
/ |
T9558 |
360-367 |
NN |
denotes |
spindle |
T9559 |
368-376 |
NNS |
denotes |
dynamics |
T9560 |
377-378 |
-LRB- |
denotes |
[ |
T9561 |
381-383 |
CD |
denotes |
22 |
T9562 |
378-380 |
CD |
denotes |
21 |
T9563 |
380-381 |
, |
denotes |
, |
T9564 |
383-384 |
-RRB- |
denotes |
] |
T9565 |
384-385 |
. |
denotes |
. |
T9566 |
385-485 |
sentence |
denotes |
This ancient TACC function is conserved throughout evolution in both protostomes and deuterostomes. |
T9567 |
386-390 |
DT |
denotes |
This |
T9568 |
404-412 |
NN |
denotes |
function |
T9569 |
391-398 |
JJ |
denotes |
ancient |
T9570 |
399-403 |
NN |
denotes |
TACC |
T9571 |
416-425 |
VBN |
denotes |
conserved |
T9572 |
413-415 |
VBZ |
denotes |
is |
T9573 |
426-436 |
IN |
denotes |
throughout |
T9574 |
437-446 |
NN |
denotes |
evolution |
T9575 |
447-449 |
IN |
denotes |
in |
T9576 |
450-454 |
CC |
denotes |
both |
T9577 |
455-466 |
NNS |
denotes |
protostomes |
T9578 |
467-470 |
CC |
denotes |
and |
T9579 |
471-484 |
NNS |
denotes |
deuterostomes |
T9580 |
484-485 |
. |
denotes |
. |
T9581 |
485-722 |
sentence |
denotes |
In addition, the TACC proteins of lower organisms appear to interact with bridging proteins that are components of several different protein complexes involved in DNA damage repair, protein translation, RNA processing and transcription. |
T9582 |
486-488 |
IN |
denotes |
In |
T9583 |
536-542 |
VBP |
denotes |
appear |
T9584 |
489-497 |
NN |
denotes |
addition |
T9585 |
497-499 |
, |
denotes |
, |
T9586 |
499-502 |
DT |
denotes |
the |
T9587 |
508-516 |
NN |
denotes |
proteins |
T9588 |
503-507 |
NN |
denotes |
TACC |
T9589 |
517-519 |
IN |
denotes |
of |
T9590 |
520-525 |
JJR |
denotes |
lower |
T9591 |
526-535 |
NNS |
denotes |
organisms |
T9592 |
543-545 |
TO |
denotes |
to |
T9593 |
546-554 |
VB |
denotes |
interact |
T9594 |
555-559 |
IN |
denotes |
with |
T9595 |
560-568 |
NN |
denotes |
bridging |
T9596 |
569-577 |
NN |
denotes |
proteins |
T9597 |
578-582 |
WDT |
denotes |
that |
T9598 |
583-586 |
VBP |
denotes |
are |
T9599 |
587-597 |
NNS |
denotes |
components |
T9600 |
598-600 |
IN |
denotes |
of |
T9601 |
601-608 |
JJ |
denotes |
several |
T9602 |
627-636 |
NNS |
denotes |
complexes |
T9603 |
609-618 |
JJ |
denotes |
different |
T9604 |
619-626 |
NN |
denotes |
protein |
T9605 |
637-645 |
VBN |
denotes |
involved |
T9606 |
646-648 |
IN |
denotes |
in |
T9607 |
649-652 |
NN |
denotes |
DNA |
T9608 |
653-659 |
NN |
denotes |
damage |
T9609 |
660-666 |
NN |
denotes |
repair |
T9610 |
666-668 |
, |
denotes |
, |
T9611 |
668-675 |
NN |
denotes |
protein |
T9612 |
676-687 |
NN |
denotes |
translation |
T9613 |
687-689 |
, |
denotes |
, |
T9614 |
689-692 |
NN |
denotes |
RNA |
T9615 |
693-703 |
NN |
denotes |
processing |
T9616 |
704-707 |
CC |
denotes |
and |
T9617 |
708-721 |
NN |
denotes |
transcription |
T9618 |
721-722 |
. |
denotes |
. |
T9619 |
722-1151 |
sentence |
denotes |
However, over the process of evolutionary time, with the acquisition of new domains and duplication of the chordate TACC precursor, the chordate TACC proteins have acquired the ability to directly interact with some of the other components of these complexes (such as the LSm proteins, nuclear hormone receptors, GAS41, accessory proteins and transcription factors), and thus evolved additional functions within these complexes. |
T9620 |
723-730 |
RB |
denotes |
However |
T9621 |
887-895 |
VBN |
denotes |
acquired |
T9622 |
730-732 |
, |
denotes |
, |
T9623 |
732-736 |
IN |
denotes |
over |
T9624 |
737-740 |
DT |
denotes |
the |
T9625 |
741-748 |
NN |
denotes |
process |
T9626 |
749-751 |
IN |
denotes |
of |
T9627 |
752-764 |
JJ |
denotes |
evolutionary |
T9628 |
765-769 |
NN |
denotes |
time |
T9629 |
769-771 |
, |
denotes |
, |
T9630 |
771-775 |
IN |
denotes |
with |
T9631 |
776-779 |
DT |
denotes |
the |
T9632 |
780-791 |
NN |
denotes |
acquisition |
T9633 |
792-794 |
IN |
denotes |
of |
T9634 |
795-798 |
JJ |
denotes |
new |
T9635 |
799-806 |
NNS |
denotes |
domains |
T9636 |
807-810 |
CC |
denotes |
and |
T9637 |
811-822 |
NN |
denotes |
duplication |
T9638 |
823-825 |
IN |
denotes |
of |
T9639 |
826-829 |
DT |
denotes |
the |
T9640 |
844-853 |
NN |
denotes |
precursor |
T9641 |
830-838 |
NN |
denotes |
chordate |
T9642 |
839-843 |
NN |
denotes |
TACC |
T9643 |
853-855 |
, |
denotes |
, |
T9644 |
855-858 |
DT |
denotes |
the |
T9645 |
873-881 |
NN |
denotes |
proteins |
T9646 |
859-867 |
NN |
denotes |
chordate |
T9647 |
868-872 |
NN |
denotes |
TACC |
T9648 |
882-886 |
VBP |
denotes |
have |
T9649 |
896-899 |
DT |
denotes |
the |
T9650 |
900-907 |
NN |
denotes |
ability |
T9651 |
908-910 |
TO |
denotes |
to |
T9652 |
920-928 |
VB |
denotes |
interact |
T9653 |
911-919 |
RB |
denotes |
directly |
T9654 |
929-933 |
IN |
denotes |
with |
T9655 |
934-938 |
DT |
denotes |
some |
T9656 |
939-941 |
IN |
denotes |
of |
T9657 |
942-945 |
DT |
denotes |
the |
T9658 |
952-962 |
NNS |
denotes |
components |
T9659 |
946-951 |
JJ |
denotes |
other |
T9660 |
963-965 |
IN |
denotes |
of |
T9661 |
966-971 |
DT |
denotes |
these |
T9662 |
972-981 |
NNS |
denotes |
complexes |
T9663 |
982-983 |
-LRB- |
denotes |
( |
T9664 |
983-987 |
JJ |
denotes |
such |
T9665 |
988-990 |
IN |
denotes |
as |
T9666 |
991-994 |
DT |
denotes |
the |
T9667 |
999-1007 |
NN |
denotes |
proteins |
T9668 |
995-998 |
NN |
denotes |
LSm |
T9669 |
1007-1009 |
, |
denotes |
, |
T9670 |
1009-1016 |
JJ |
denotes |
nuclear |
T9671 |
1025-1034 |
NNS |
denotes |
receptors |
T9672 |
1017-1024 |
NN |
denotes |
hormone |
T9673 |
1034-1036 |
, |
denotes |
, |
T9674 |
1036-1041 |
NN |
denotes |
GAS41 |
T9675 |
1041-1043 |
, |
denotes |
, |
T9676 |
1043-1052 |
JJ |
denotes |
accessory |
T9677 |
1053-1061 |
NN |
denotes |
proteins |
T9678 |
1062-1065 |
CC |
denotes |
and |
T9679 |
1066-1079 |
NN |
denotes |
transcription |
T9680 |
1080-1087 |
NNS |
denotes |
factors |
T9681 |
1087-1088 |
-RRB- |
denotes |
) |
T9682 |
1088-1090 |
, |
denotes |
, |
T9683 |
1090-1093 |
CC |
denotes |
and |
T9684 |
1094-1098 |
RB |
denotes |
thus |
T9685 |
1099-1106 |
VBD |
denotes |
evolved |
T9686 |
1107-1117 |
JJ |
denotes |
additional |
T9687 |
1118-1127 |
NNS |
denotes |
functions |
T9688 |
1128-1134 |
IN |
denotes |
within |
T9689 |
1135-1140 |
DT |
denotes |
these |
T9690 |
1141-1150 |
NNS |
denotes |
complexes |
T9691 |
1150-1151 |
. |
denotes |
. |
T9692 |
1151-1359 |
sentence |
denotes |
Indeed, the first assigned function of a vertebrate TACC protein, mouse TACC3, was as a transcriptional coactivator of the ARNT mediated transcriptional response to hypoxia and polyaromatic hydrocarbons [7]. |
T9693 |
1152-1158 |
RB |
denotes |
Indeed |
T9694 |
1231-1234 |
VBD |
denotes |
was |
T9695 |
1158-1160 |
, |
denotes |
, |
T9696 |
1160-1163 |
DT |
denotes |
the |
T9697 |
1179-1187 |
NN |
denotes |
function |
T9698 |
1164-1169 |
JJ |
denotes |
first |
T9699 |
1170-1178 |
VBN |
denotes |
assigned |
T9700 |
1188-1190 |
IN |
denotes |
of |
T9701 |
1191-1192 |
DT |
denotes |
a |
T9702 |
1209-1216 |
NN |
denotes |
protein |
T9703 |
1193-1203 |
NN |
denotes |
vertebrate |
T9704 |
1204-1208 |
NN |
denotes |
TACC |
T9705 |
1216-1218 |
, |
denotes |
, |
T9706 |
1218-1223 |
NN |
denotes |
mouse |
T9707 |
1224-1229 |
NN |
denotes |
TACC3 |
T9708 |
1229-1231 |
, |
denotes |
, |
T9709 |
1235-1237 |
IN |
denotes |
as |
T9710 |
1238-1239 |
DT |
denotes |
a |
T9711 |
1256-1267 |
NN |
denotes |
coactivator |
T9712 |
1240-1255 |
JJ |
denotes |
transcriptional |
T9713 |
1268-1270 |
IN |
denotes |
of |
T9714 |
1271-1274 |
DT |
denotes |
the |
T9715 |
1305-1313 |
NN |
denotes |
response |
T9716 |
1275-1279 |
NN |
denotes |
ARNT |
T9717 |
1280-1288 |
VBN |
denotes |
mediated |
T9718 |
1289-1304 |
JJ |
denotes |
transcriptional |
T9719 |
1314-1316 |
IN |
denotes |
to |
T9720 |
1317-1324 |
NN |
denotes |
hypoxia |
T9721 |
1325-1328 |
CC |
denotes |
and |
T9722 |
1329-1341 |
JJ |
denotes |
polyaromatic |
T9723 |
1342-1354 |
NNS |
denotes |
hydrocarbons |
T9724 |
1355-1356 |
-LRB- |
denotes |
[ |
T9725 |
1356-1357 |
CD |
denotes |
7 |
T9726 |
1357-1358 |
-RRB- |
denotes |
] |
T9727 |
1358-1359 |
. |
denotes |
. |
T9728 |
1359-1448 |
sentence |
denotes |
Mouse TACC3 has also been reported to interact with the transcription factor STAT5 [33]. |
T9729 |
1360-1365 |
NN |
denotes |
Mouse |
T9730 |
1366-1371 |
NN |
denotes |
TACC3 |
T9731 |
1386-1394 |
VBN |
denotes |
reported |
T9732 |
1372-1375 |
VBZ |
denotes |
has |
T9733 |
1376-1380 |
RB |
denotes |
also |
T9734 |
1381-1385 |
VBN |
denotes |
been |
T9735 |
1395-1397 |
TO |
denotes |
to |
T9736 |
1398-1406 |
VB |
denotes |
interact |
T9737 |
1407-1411 |
IN |
denotes |
with |
T9738 |
1412-1415 |
DT |
denotes |
the |
T9739 |
1437-1442 |
NN |
denotes |
STAT5 |
T9740 |
1416-1429 |
NN |
denotes |
transcription |
T9741 |
1430-1436 |
NN |
denotes |
factor |
T9742 |
1443-1444 |
-LRB- |
denotes |
[ |
T9743 |
1444-1446 |
CD |
denotes |
33 |
T9744 |
1446-1447 |
-RRB- |
denotes |
] |
T9745 |
1447-1448 |
. |
denotes |
. |
T9746 |
1448-1665 |
sentence |
denotes |
Recently, we have demonstrated that TACC2 and TACC3 can bind to nuclear histone acetyltransferases [34], further confirming a more direct role for the TACC proteins in transcriptional and chromatin remodeling events. |
T9747 |
1449-1457 |
RB |
denotes |
Recently |
T9748 |
1467-1479 |
VBN |
denotes |
demonstrated |
T9749 |
1457-1459 |
, |
denotes |
, |
T9750 |
1459-1461 |
PRP |
denotes |
we |
T9751 |
1462-1466 |
VBP |
denotes |
have |
T9752 |
1480-1484 |
IN |
denotes |
that |
T9753 |
1505-1509 |
VB |
denotes |
bind |
T9754 |
1485-1490 |
NN |
denotes |
TACC2 |
T9755 |
1491-1494 |
CC |
denotes |
and |
T9756 |
1495-1500 |
NN |
denotes |
TACC3 |
T9757 |
1501-1504 |
MD |
denotes |
can |
T9758 |
1510-1512 |
IN |
denotes |
to |
T9759 |
1513-1520 |
JJ |
denotes |
nuclear |
T9760 |
1529-1547 |
NNS |
denotes |
acetyltransferases |
T9761 |
1521-1528 |
NN |
denotes |
histone |
T9762 |
1548-1549 |
-LRB- |
denotes |
[ |
T9763 |
1549-1551 |
CD |
denotes |
34 |
T9764 |
1551-1552 |
-RRB- |
denotes |
] |
T9765 |
1552-1554 |
, |
denotes |
, |
T9766 |
1554-1561 |
RB |
denotes |
further |
T9767 |
1562-1572 |
VBG |
denotes |
confirming |
T9768 |
1573-1574 |
DT |
denotes |
a |
T9769 |
1587-1591 |
NN |
denotes |
role |
T9770 |
1575-1579 |
RBR |
denotes |
more |
T9771 |
1580-1586 |
JJ |
denotes |
direct |
T9772 |
1592-1595 |
IN |
denotes |
for |
T9773 |
1596-1599 |
DT |
denotes |
the |
T9774 |
1605-1613 |
NN |
denotes |
proteins |
T9775 |
1600-1604 |
NN |
denotes |
TACC |
T9776 |
1614-1616 |
IN |
denotes |
in |
T9777 |
1617-1632 |
JJ |
denotes |
transcriptional |
T9778 |
1658-1664 |
NNS |
denotes |
events |
T9779 |
1633-1636 |
CC |
denotes |
and |
T9780 |
1637-1646 |
NN |
denotes |
chromatin |
T9781 |
1647-1657 |
NN |
denotes |
remodeling |
T9782 |
1664-1665 |
. |
denotes |
. |
T9783 |
1665-1892 |
sentence |
denotes |
Interestingly although all human TACC proteins can directly interact with the histone acetyltransferase pCAF in vitro, the TACC1 isoforms expressed in human breast cancer cells do not interact with this histone acetylase [34]. |
T9784 |
1666-1679 |
RB |
denotes |
Interestingly |
T9785 |
1850-1858 |
VB |
denotes |
interact |
T9786 |
1680-1688 |
IN |
denotes |
although |
T9787 |
1726-1734 |
VB |
denotes |
interact |
T9788 |
1689-1692 |
DT |
denotes |
all |
T9789 |
1704-1712 |
NN |
denotes |
proteins |
T9790 |
1693-1698 |
JJ |
denotes |
human |
T9791 |
1699-1703 |
NN |
denotes |
TACC |
T9792 |
1713-1716 |
MD |
denotes |
can |
T9793 |
1717-1725 |
RB |
denotes |
directly |
T9794 |
1735-1739 |
IN |
denotes |
with |
T9795 |
1740-1743 |
DT |
denotes |
the |
T9796 |
1752-1769 |
NN |
denotes |
acetyltransferase |
T9797 |
1744-1751 |
NN |
denotes |
histone |
T9798 |
1770-1774 |
NN |
denotes |
pCAF |
T9799 |
1775-1777 |
FW |
denotes |
in |
T9800 |
1778-1783 |
FW |
denotes |
vitro |
T9801 |
1783-1785 |
, |
denotes |
, |
T9802 |
1785-1788 |
DT |
denotes |
the |
T9803 |
1795-1803 |
NNS |
denotes |
isoforms |
T9804 |
1789-1794 |
NN |
denotes |
TACC1 |
T9805 |
1804-1813 |
VBN |
denotes |
expressed |
T9806 |
1814-1816 |
IN |
denotes |
in |
T9807 |
1817-1822 |
JJ |
denotes |
human |
T9808 |
1837-1842 |
NNS |
denotes |
cells |
T9809 |
1823-1829 |
NN |
denotes |
breast |
T9810 |
1830-1836 |
NN |
denotes |
cancer |
T9811 |
1843-1845 |
VBP |
denotes |
do |
T9812 |
1846-1849 |
RB |
denotes |
not |
T9813 |
1859-1863 |
IN |
denotes |
with |
T9814 |
1864-1868 |
DT |
denotes |
this |
T9815 |
1877-1886 |
NN |
denotes |
acetylase |
T9816 |
1869-1876 |
NN |
denotes |
histone |
T9817 |
1887-1888 |
-LRB- |
denotes |
[ |
T9818 |
1888-1890 |
CD |
denotes |
34 |
T9819 |
1890-1891 |
-RRB- |
denotes |
] |
T9820 |
1891-1892 |
. |
denotes |
. |
T9821 |
1892-2046 |
sentence |
denotes |
This may be attributable to the proposed function of the Exon 1 containing TACC1 variants in RNA processing, via the interaction with LSm-7 and SmG [19]. |
T9822 |
1893-1897 |
DT |
denotes |
This |
T9823 |
1902-1904 |
VB |
denotes |
be |
T9824 |
1898-1901 |
MD |
denotes |
may |
T9825 |
1905-1917 |
JJ |
denotes |
attributable |
T9826 |
1918-1920 |
IN |
denotes |
to |
T9827 |
1921-1924 |
DT |
denotes |
the |
T9828 |
1934-1942 |
NN |
denotes |
function |
T9829 |
1925-1933 |
VBN |
denotes |
proposed |
T9830 |
1943-1945 |
IN |
denotes |
of |
T9831 |
1946-1949 |
DT |
denotes |
the |
T9832 |
1974-1982 |
NNS |
denotes |
variants |
T9833 |
1950-1954 |
NN |
denotes |
Exon |
T9834 |
1957-1967 |
VBG |
denotes |
containing |
T9835 |
1955-1956 |
CD |
denotes |
1 |
T9836 |
1968-1973 |
NN |
denotes |
TACC1 |
T9837 |
1983-1985 |
IN |
denotes |
in |
T9838 |
1986-1989 |
NN |
denotes |
RNA |
T9839 |
1990-2000 |
NN |
denotes |
processing |
T9840 |
2000-2002 |
, |
denotes |
, |
T9841 |
2002-2005 |
IN |
denotes |
via |
T9842 |
2006-2009 |
DT |
denotes |
the |
T9843 |
2010-2021 |
NN |
denotes |
interaction |
T9844 |
2022-2026 |
IN |
denotes |
with |
T9845 |
2027-2030 |
NN |
denotes |
LSm |
T9846 |
2030-2031 |
HYPH |
denotes |
- |
T9847 |
2031-2032 |
CD |
denotes |
7 |
T9848 |
2033-2036 |
CC |
denotes |
and |
T9849 |
2037-2040 |
NN |
denotes |
SmG |
T9850 |
2041-2042 |
-LRB- |
denotes |
[ |
T9851 |
2042-2044 |
CD |
denotes |
19 |
T9852 |
2044-2045 |
-RRB- |
denotes |
] |
T9853 |
2045-2046 |
. |
denotes |
. |
T9854 |
2046-2373 |
sentence |
denotes |
Thus, alternative splicing of the TACC1 gene adds further diversity to TACC1 function, as the deletion of specific exons and their associated binding domains will change the potential protein complexes with which they can associate, either directly, or by redirecting the splice variants to different subcellular compartments. |
T9855 |
2047-2051 |
RB |
denotes |
Thus |
T9856 |
2092-2096 |
VBZ |
denotes |
adds |
T9857 |
2051-2053 |
, |
denotes |
, |
T9858 |
2053-2064 |
JJ |
denotes |
alternative |
T9859 |
2065-2073 |
NN |
denotes |
splicing |
T9860 |
2074-2076 |
IN |
denotes |
of |
T9861 |
2077-2080 |
DT |
denotes |
the |
T9862 |
2087-2091 |
NN |
denotes |
gene |
T9863 |
2081-2086 |
NN |
denotes |
TACC1 |
T9864 |
2097-2104 |
JJ |
denotes |
further |
T9865 |
2105-2114 |
NN |
denotes |
diversity |
T9866 |
2115-2117 |
IN |
denotes |
to |
T9867 |
2118-2123 |
NN |
denotes |
TACC1 |
T9868 |
2124-2132 |
NN |
denotes |
function |
T9869 |
2132-2134 |
, |
denotes |
, |
T9870 |
2134-2136 |
IN |
denotes |
as |
T9871 |
2210-2216 |
VB |
denotes |
change |
T9872 |
2137-2140 |
DT |
denotes |
the |
T9873 |
2141-2149 |
NN |
denotes |
deletion |
T9874 |
2150-2152 |
IN |
denotes |
of |
T9875 |
2153-2161 |
JJ |
denotes |
specific |
T9876 |
2162-2167 |
NNS |
denotes |
exons |
T9877 |
2168-2171 |
CC |
denotes |
and |
T9878 |
2172-2177 |
PRP$ |
denotes |
their |
T9879 |
2197-2204 |
NNS |
denotes |
domains |
T9880 |
2178-2188 |
VBN |
denotes |
associated |
T9881 |
2189-2196 |
NN |
denotes |
binding |
T9882 |
2205-2209 |
MD |
denotes |
will |
T9883 |
2217-2220 |
DT |
denotes |
the |
T9884 |
2239-2248 |
NNS |
denotes |
complexes |
T9885 |
2221-2230 |
JJ |
denotes |
potential |
T9886 |
2231-2238 |
NN |
denotes |
protein |
T9887 |
2249-2253 |
IN |
denotes |
with |
T9888 |
2269-2278 |
VB |
denotes |
associate |
T9889 |
2254-2259 |
WDT |
denotes |
which |
T9890 |
2260-2264 |
PRP |
denotes |
they |
T9891 |
2265-2268 |
MD |
denotes |
can |
T9892 |
2278-2280 |
, |
denotes |
, |
T9893 |
2280-2286 |
CC |
denotes |
either |
T9894 |
2300-2302 |
IN |
denotes |
by |
T9895 |
2287-2295 |
RB |
denotes |
directly |
T9896 |
2295-2297 |
, |
denotes |
, |
T9897 |
2297-2299 |
CC |
denotes |
or |
T9898 |
2303-2314 |
VBG |
denotes |
redirecting |
T9899 |
2315-2318 |
DT |
denotes |
the |
T9900 |
2326-2334 |
NNS |
denotes |
variants |
T9901 |
2319-2325 |
NN |
denotes |
splice |
T9902 |
2335-2337 |
IN |
denotes |
to |
T9903 |
2338-2347 |
JJ |
denotes |
different |
T9904 |
2360-2372 |
NNS |
denotes |
compartments |
T9905 |
2348-2359 |
JJ |
denotes |
subcellular |
T9906 |
2372-2373 |
. |
denotes |
. |
T9907 |
2373-2527 |
sentence |
denotes |
With the duplication of the TACC1/TACC2 ancestor, it is apparent that an even greater functional diversity may have been introduced into the TACC family. |
T9908 |
2374-2378 |
IN |
denotes |
With |
T9909 |
2427-2429 |
VBZ |
denotes |
is |
T9910 |
2379-2382 |
DT |
denotes |
the |
T9911 |
2383-2394 |
NN |
denotes |
duplication |
T9912 |
2395-2397 |
IN |
denotes |
of |
T9913 |
2398-2401 |
DT |
denotes |
the |
T9914 |
2414-2422 |
NN |
denotes |
ancestor |
T9915 |
2402-2407 |
NN |
denotes |
TACC1 |
T9916 |
2408-2413 |
NN |
denotes |
TACC2 |
T9917 |
2407-2408 |
HYPH |
denotes |
/ |
T9918 |
2422-2424 |
, |
denotes |
, |
T9919 |
2424-2426 |
PRP |
denotes |
it |
T9920 |
2430-2438 |
JJ |
denotes |
apparent |
T9921 |
2439-2443 |
IN |
denotes |
that |
T9922 |
2495-2505 |
VBN |
denotes |
introduced |
T9923 |
2444-2446 |
DT |
denotes |
an |
T9924 |
2471-2480 |
NN |
denotes |
diversity |
T9925 |
2447-2451 |
RB |
denotes |
even |
T9926 |
2452-2459 |
JJR |
denotes |
greater |
T9927 |
2460-2470 |
JJ |
denotes |
functional |
T9928 |
2481-2484 |
MD |
denotes |
may |
T9929 |
2485-2489 |
VB |
denotes |
have |
T9930 |
2490-2494 |
VBN |
denotes |
been |
T9931 |
2506-2510 |
IN |
denotes |
into |
T9932 |
2511-2514 |
DT |
denotes |
the |
T9933 |
2520-2526 |
NN |
denotes |
family |
T9934 |
2515-2519 |
NN |
denotes |
TACC |
T9935 |
2526-2527 |
. |
denotes |
. |
T9936 |
2527-2695 |
sentence |
denotes |
The TACC2 protein retains the ability of TACC3 to interact with GAS41, INI1, histone acetyltransferases and transcription factors (in this case, RXRβ) (Fig. 7) [3,34]. |
T9937 |
2528-2531 |
DT |
denotes |
The |
T9938 |
2538-2545 |
NN |
denotes |
protein |
T9939 |
2532-2537 |
NN |
denotes |
TACC2 |
T9940 |
2546-2553 |
VBZ |
denotes |
retains |
T9941 |
2554-2557 |
DT |
denotes |
the |
T9942 |
2558-2565 |
NN |
denotes |
ability |
T9943 |
2566-2568 |
IN |
denotes |
of |
T9944 |
2569-2574 |
NN |
denotes |
TACC3 |
T9945 |
2575-2577 |
TO |
denotes |
to |
T9946 |
2578-2586 |
VB |
denotes |
interact |
T9947 |
2587-2591 |
IN |
denotes |
with |
T9948 |
2592-2597 |
NN |
denotes |
GAS41 |
T9949 |
2597-2599 |
, |
denotes |
, |
T9950 |
2599-2603 |
NN |
denotes |
INI1 |
T9951 |
2603-2605 |
, |
denotes |
, |
T9952 |
2605-2612 |
NN |
denotes |
histone |
T9953 |
2613-2631 |
NNS |
denotes |
acetyltransferases |
T9954 |
2632-2635 |
CC |
denotes |
and |
T9955 |
2636-2649 |
NN |
denotes |
transcription |
T9956 |
2650-2657 |
NNS |
denotes |
factors |
T9957 |
2658-2659 |
-LRB- |
denotes |
( |
T9958 |
2659-2661 |
IN |
denotes |
in |
T9959 |
2673-2677 |
NN |
denotes |
RXRβ |
T9960 |
2662-2666 |
DT |
denotes |
this |
T9961 |
2667-2671 |
NN |
denotes |
case |
T9962 |
2671-2673 |
, |
denotes |
, |
T9963 |
2677-2678 |
-RRB- |
denotes |
) |
T9964 |
2679-2680 |
-LRB- |
denotes |
( |
T9965 |
2680-2684 |
NN |
denotes |
Fig. |
T9966 |
2685-2686 |
CD |
denotes |
7 |
T9967 |
2686-2687 |
-RRB- |
denotes |
) |
T9968 |
2688-2689 |
-LRB- |
denotes |
[ |
T9969 |
2691-2693 |
CD |
denotes |
34 |
T9970 |
2689-2690 |
CD |
denotes |
3 |
T9971 |
2690-2691 |
, |
denotes |
, |
T9972 |
2693-2694 |
-RRB- |
denotes |
] |
T9973 |
2694-2695 |
. |
denotes |
. |
T9974 |
2695-2877 |
sentence |
denotes |
However, the tissue specific splicing of the 5 kb exon in the TACC2l isoform [3] indicates that this protein has several temporal and tissue specific functions yet to be identified. |
T9975 |
2696-2703 |
RB |
denotes |
However |
T9976 |
2777-2786 |
VBZ |
denotes |
indicates |
T9977 |
2703-2705 |
, |
denotes |
, |
T9978 |
2705-2708 |
DT |
denotes |
the |
T9979 |
2725-2733 |
NN |
denotes |
splicing |
T9980 |
2709-2715 |
NN |
denotes |
tissue |
T9981 |
2716-2724 |
JJ |
denotes |
specific |
T9982 |
2734-2736 |
IN |
denotes |
of |
T9983 |
2737-2740 |
DT |
denotes |
the |
T9984 |
2746-2750 |
NN |
denotes |
exon |
T9985 |
2741-2742 |
CD |
denotes |
5 |
T9986 |
2743-2745 |
NN |
denotes |
kb |
T9987 |
2751-2753 |
IN |
denotes |
in |
T9988 |
2754-2757 |
DT |
denotes |
the |
T9989 |
2765-2772 |
NN |
denotes |
isoform |
T9990 |
2758-2764 |
NN |
denotes |
TACC2l |
T9991 |
2773-2774 |
-LRB- |
denotes |
[ |
T9992 |
2774-2775 |
CD |
denotes |
3 |
T9993 |
2775-2776 |
-RRB- |
denotes |
] |
T9994 |
2787-2791 |
IN |
denotes |
that |
T9995 |
2805-2808 |
VBZ |
denotes |
has |
T9996 |
2792-2796 |
DT |
denotes |
this |
T9997 |
2797-2804 |
NN |
denotes |
protein |
T9998 |
2809-2816 |
JJ |
denotes |
several |
T9999 |
2846-2855 |
NNS |
denotes |
functions |
T10000 |
2817-2825 |
JJ |
denotes |
temporal |
T10001 |
2826-2829 |
CC |
denotes |
and |
T10002 |
2830-2836 |
NN |
denotes |
tissue |
T10003 |
2837-2845 |
JJ |
denotes |
specific |
T10004 |
2856-2859 |
RB |
denotes |
yet |
T10005 |
2866-2876 |
VBN |
denotes |
identified |
T10006 |
2860-2862 |
TO |
denotes |
to |
T10007 |
2863-2865 |
VB |
denotes |
be |
T10008 |
2876-2877 |
. |
denotes |
. |
R6202 |
T9719 |
T9715 |
prep |
to,response |
R6203 |
T9720 |
T9719 |
pobj |
hypoxia,to |
R6204 |
T9721 |
T9720 |
cc |
and,hypoxia |
R6205 |
T9722 |
T9723 |
amod |
polyaromatic,hydrocarbons |
R6206 |
T9723 |
T9720 |
conj |
hydrocarbons,hypoxia |
R6207 |
T9724 |
T9725 |
punct |
[,7 |
R6208 |
T9725 |
T9694 |
parataxis |
7,was |
R6209 |
T9726 |
T9725 |
punct |
],7 |
R6210 |
T9727 |
T9694 |
punct |
.,was |
R6211 |
T9729 |
T9730 |
compound |
Mouse,TACC3 |
R6212 |
T9730 |
T9731 |
nsubjpass |
TACC3,reported |
R6213 |
T9732 |
T9731 |
aux |
has,reported |
R6214 |
T9733 |
T9731 |
advmod |
also,reported |
R6215 |
T9734 |
T9731 |
auxpass |
been,reported |
R6216 |
T9735 |
T9736 |
aux |
to,interact |
R6217 |
T9736 |
T9731 |
xcomp |
interact,reported |
R6218 |
T9737 |
T9736 |
prep |
with,interact |
R6219 |
T9738 |
T9739 |
det |
the,STAT5 |
R6220 |
T9739 |
T9737 |
pobj |
STAT5,with |
R6221 |
T9740 |
T9739 |
compound |
transcription,STAT5 |
R6222 |
T9741 |
T9739 |
compound |
factor,STAT5 |
R6223 |
T9742 |
T9743 |
punct |
[,33 |
R6224 |
T9743 |
T9731 |
parataxis |
33,reported |
R6225 |
T9744 |
T9743 |
punct |
],33 |
R6226 |
T9745 |
T9731 |
punct |
.,reported |
R6227 |
T9747 |
T9748 |
advmod |
Recently,demonstrated |
R6228 |
T9749 |
T9748 |
punct |
", ",demonstrated |
R6229 |
T9750 |
T9748 |
nsubj |
we,demonstrated |
R6230 |
T9751 |
T9748 |
aux |
have,demonstrated |
R6231 |
T9752 |
T9753 |
mark |
that,bind |
R6232 |
T9753 |
T9748 |
ccomp |
bind,demonstrated |
R6233 |
T9754 |
T9753 |
nsubj |
TACC2,bind |
R6234 |
T9755 |
T9754 |
cc |
and,TACC2 |
R6235 |
T9756 |
T9754 |
conj |
TACC3,TACC2 |
R6236 |
T9757 |
T9753 |
aux |
can,bind |
R6237 |
T9758 |
T9753 |
prep |
to,bind |
R6238 |
T9759 |
T9760 |
amod |
nuclear,acetyltransferases |
R6239 |
T9760 |
T9758 |
pobj |
acetyltransferases,to |
R6240 |
T9761 |
T9760 |
compound |
histone,acetyltransferases |
R6241 |
T9762 |
T9763 |
punct |
[,34 |
R6242 |
T9763 |
T9748 |
parataxis |
34,demonstrated |
R6243 |
T9764 |
T9763 |
punct |
],34 |
R6244 |
T9765 |
T9748 |
punct |
", ",demonstrated |
R6245 |
T9766 |
T9767 |
advmod |
further,confirming |
R6246 |
T9767 |
T9748 |
advcl |
confirming,demonstrated |
R6247 |
T9768 |
T9769 |
det |
a,role |
R6248 |
T9769 |
T9767 |
dobj |
role,confirming |
R6249 |
T9770 |
T9771 |
advmod |
more,direct |
R6250 |
T9771 |
T9769 |
amod |
direct,role |
R6251 |
T9772 |
T9769 |
prep |
for,role |
R6252 |
T9773 |
T9774 |
det |
the,proteins |
R6253 |
T9774 |
T9772 |
pobj |
proteins,for |
R6254 |
T9775 |
T9774 |
compound |
TACC,proteins |
R6255 |
T9776 |
T9769 |
prep |
in,role |
R6256 |
T9777 |
T9778 |
amod |
transcriptional,events |
R6257 |
T9778 |
T9776 |
pobj |
events,in |
R6258 |
T9779 |
T9777 |
cc |
and,transcriptional |
R6259 |
T9780 |
T9781 |
compound |
chromatin,remodeling |
R6260 |
T9781 |
T9777 |
conj |
remodeling,transcriptional |
R6261 |
T9782 |
T9748 |
punct |
.,demonstrated |
R6262 |
T9784 |
T9785 |
advmod |
Interestingly,interact |
R6263 |
T9786 |
T9787 |
mark |
although,interact |
R6264 |
T9787 |
T9785 |
advcl |
interact,interact |
R6265 |
T9788 |
T9789 |
det |
all,proteins |
R6266 |
T9789 |
T9787 |
nsubj |
proteins,interact |
R6267 |
T9790 |
T9789 |
amod |
human,proteins |
R6268 |
T9791 |
T9789 |
compound |
TACC,proteins |
R6269 |
T9792 |
T9787 |
aux |
can,interact |
R6270 |
T9793 |
T9787 |
advmod |
directly,interact |
R6271 |
T9794 |
T9787 |
prep |
with,interact |
R6272 |
T9795 |
T9796 |
det |
the,acetyltransferase |
R6273 |
T9796 |
T9794 |
pobj |
acetyltransferase,with |
R6274 |
T9797 |
T9796 |
compound |
histone,acetyltransferase |
R6275 |
T9798 |
T9796 |
appos |
pCAF,acetyltransferase |
R6276 |
T9799 |
T9800 |
advmod |
in,vitro |
R6277 |
T9800 |
T9787 |
advmod |
vitro,interact |
R6278 |
T9801 |
T9785 |
punct |
", ",interact |
R6279 |
T9802 |
T9803 |
det |
the,isoforms |
R6280 |
T9803 |
T9785 |
nsubj |
isoforms,interact |
R6281 |
T9804 |
T9803 |
compound |
TACC1,isoforms |
R6282 |
T9805 |
T9803 |
acl |
expressed,isoforms |
R6283 |
T9806 |
T9805 |
prep |
in,expressed |
R6284 |
T9807 |
T9808 |
amod |
human,cells |
R6285 |
T9808 |
T9806 |
pobj |
cells,in |
R6286 |
T9809 |
T9810 |
compound |
breast,cancer |
R6287 |
T9810 |
T9808 |
compound |
cancer,cells |
R6288 |
T9811 |
T9785 |
aux |
do,interact |
R6289 |
T9812 |
T9785 |
neg |
not,interact |
R6290 |
T9813 |
T9785 |
prep |
with,interact |
R6291 |
T9814 |
T9815 |
det |
this,acetylase |
R6292 |
T9815 |
T9813 |
pobj |
acetylase,with |
R6293 |
T9816 |
T9815 |
compound |
histone,acetylase |
R6294 |
T9817 |
T9818 |
punct |
[,34 |
R6295 |
T9818 |
T9785 |
parataxis |
34,interact |
R6296 |
T9819 |
T9818 |
punct |
],34 |
R6297 |
T9820 |
T9785 |
punct |
.,interact |
R6298 |
T9822 |
T9823 |
nsubj |
This,be |
R6299 |
T9824 |
T9823 |
aux |
may,be |
R6300 |
T9825 |
T9823 |
acomp |
attributable,be |
R6301 |
T9826 |
T9825 |
prep |
to,attributable |
R6302 |
T9827 |
T9828 |
det |
the,function |
R6303 |
T9828 |
T9826 |
pobj |
function,to |
R6304 |
T9829 |
T9828 |
amod |
proposed,function |
R6305 |
T9830 |
T9828 |
prep |
of,function |
R6306 |
T9831 |
T9832 |
det |
the,variants |
R6307 |
T9832 |
T9830 |
pobj |
variants,of |
R6308 |
T9833 |
T9834 |
npadvmod |
Exon,containing |
R6309 |
T9834 |
T9832 |
amod |
containing,variants |
R6310 |
T9835 |
T9833 |
nummod |
1,Exon |
R6311 |
T9836 |
T9832 |
compound |
TACC1,variants |
R6312 |
T9837 |
T9832 |
prep |
in,variants |
R6313 |
T9838 |
T9839 |
compound |
RNA,processing |
R6314 |
T9839 |
T9837 |
pobj |
processing,in |
R6315 |
T9840 |
T9823 |
punct |
", ",be |
R6316 |
T9841 |
T9823 |
prep |
via,be |
R6317 |
T9842 |
T9843 |
det |
the,interaction |
R6318 |
T9843 |
T9841 |
pobj |
interaction,via |
R6319 |
T9844 |
T9843 |
prep |
with,interaction |
R6320 |
T9845 |
T9844 |
pobj |
LSm,with |
R6321 |
T9846 |
T9845 |
punct |
-,LSm |
R6322 |
T9847 |
T9845 |
nummod |
7,LSm |
R6323 |
T9848 |
T9845 |
cc |
and,LSm |
R6324 |
T9849 |
T9845 |
conj |
SmG,LSm |
R6325 |
T9850 |
T9851 |
punct |
[,19 |
R6326 |
T9851 |
T9823 |
parataxis |
19,be |
R6327 |
T9852 |
T9851 |
punct |
],19 |
R6328 |
T9853 |
T9823 |
punct |
.,be |
R6329 |
T9855 |
T9856 |
advmod |
Thus,adds |
R6330 |
T9857 |
T9856 |
punct |
", ",adds |
R6331 |
T9858 |
T9859 |
amod |
alternative,splicing |
R6332 |
T9859 |
T9856 |
nsubj |
splicing,adds |
R6333 |
T9860 |
T9859 |
prep |
of,splicing |
R6334 |
T9861 |
T9862 |
det |
the,gene |
R6335 |
T9862 |
T9860 |
pobj |
gene,of |
R6336 |
T9863 |
T9862 |
compound |
TACC1,gene |
R6337 |
T9864 |
T9865 |
amod |
further,diversity |
R6338 |
T9865 |
T9856 |
dobj |
diversity,adds |
R6339 |
T9866 |
T9856 |
prep |
to,adds |
R6340 |
T9867 |
T9868 |
compound |
TACC1,function |
R6341 |
T9868 |
T9866 |
pobj |
function,to |
R6342 |
T9869 |
T9856 |
punct |
", ",adds |
R6343 |
T9870 |
T9871 |
mark |
as,change |
R6344 |
T9871 |
T9856 |
advcl |
change,adds |
R6345 |
T9872 |
T9873 |
det |
the,deletion |
R6346 |
T9873 |
T9871 |
nsubj |
deletion,change |
R6347 |
T9874 |
T9873 |
prep |
of,deletion |
R6348 |
T9875 |
T9876 |
amod |
specific,exons |
R6349 |
T9876 |
T9874 |
pobj |
exons,of |
R6350 |
T9877 |
T9876 |
cc |
and,exons |
R6351 |
T9878 |
T9879 |
poss |
their,domains |
R6352 |
T9879 |
T9876 |
conj |
domains,exons |
R6353 |
T9880 |
T9879 |
amod |
associated,domains |
R6354 |
T9881 |
T9879 |
compound |
binding,domains |
R6355 |
T9882 |
T9871 |
aux |
will,change |
R6356 |
T9883 |
T9884 |
det |
the,complexes |
R6357 |
T9884 |
T9871 |
dobj |
complexes,change |
R6358 |
T9885 |
T9884 |
amod |
potential,complexes |
R6359 |
T9886 |
T9884 |
compound |
protein,complexes |
R6360 |
T9887 |
T9888 |
prep |
with,associate |
R6361 |
T9888 |
T9884 |
relcl |
associate,complexes |
R6362 |
T9889 |
T9887 |
pobj |
which,with |
R6363 |
T9890 |
T9888 |
nsubj |
they,associate |
R6364 |
T9891 |
T9888 |
aux |
can,associate |
R6365 |
T9892 |
T9871 |
punct |
", ",change |
R6366 |
T9893 |
T9894 |
preconj |
either,by |
R6367 |
T9894 |
T9871 |
prep |
by,change |
R6368 |
T9895 |
T9894 |
advmod |
directly,by |
R6369 |
T9896 |
T9894 |
punct |
", ",by |
R6370 |
T9897 |
T9894 |
cc |
or,by |
R6371 |
T9898 |
T9894 |
pcomp |
redirecting,by |
R6372 |
T9899 |
T9900 |
det |
the,variants |
R6373 |
T9900 |
T9898 |
dobj |
variants,redirecting |
R6374 |
T9901 |
T9900 |
compound |
splice,variants |
R6375 |
T9902 |
T9898 |
prep |
to,redirecting |
R6376 |
T9903 |
T9904 |
amod |
different,compartments |
R6377 |
T9904 |
T9902 |
pobj |
compartments,to |
R6378 |
T9905 |
T9904 |
amod |
subcellular,compartments |
R6379 |
T9906 |
T9856 |
punct |
.,adds |
R6380 |
T9908 |
T9909 |
prep |
With,is |
R6381 |
T9910 |
T9911 |
det |
the,duplication |
R6382 |
T9911 |
T9908 |
pobj |
duplication,With |
R6383 |
T9912 |
T9911 |
prep |
of,duplication |
R6384 |
T9913 |
T9914 |
det |
the,ancestor |
R6385 |
T9914 |
T9912 |
pobj |
ancestor,of |
R6386 |
T9915 |
T9916 |
compound |
TACC1,TACC2 |
R6387 |
T9916 |
T9914 |
compound |
TACC2,ancestor |
R6388 |
T9917 |
T9916 |
punct |
/,TACC2 |
R6389 |
T9918 |
T9909 |
punct |
", ",is |
R6390 |
T9919 |
T9909 |
nsubj |
it,is |
R6391 |
T9920 |
T9909 |
acomp |
apparent,is |
R6392 |
T9921 |
T9922 |
mark |
that,introduced |
R6393 |
T9922 |
T9909 |
ccomp |
introduced,is |
R6394 |
T9923 |
T9924 |
det |
an,diversity |
R6395 |
T9924 |
T9922 |
nsubjpass |
diversity,introduced |
R6396 |
T9925 |
T9926 |
advmod |
even,greater |
R6397 |
T9926 |
T9924 |
amod |
greater,diversity |
R6398 |
T9927 |
T9924 |
amod |
functional,diversity |
R6399 |
T9928 |
T9922 |
aux |
may,introduced |
R6400 |
T9929 |
T9922 |
aux |
have,introduced |
R6401 |
T9930 |
T9922 |
auxpass |
been,introduced |
R6402 |
T9931 |
T9922 |
prep |
into,introduced |
R6403 |
T9932 |
T9933 |
det |
the,family |
R6404 |
T9933 |
T9931 |
pobj |
family,into |
R6405 |
T9934 |
T9933 |
compound |
TACC,family |
R6406 |
T9935 |
T9909 |
punct |
.,is |
R6407 |
T9937 |
T9938 |
det |
The,protein |
R6408 |
T9938 |
T9940 |
nsubj |
protein,retains |
R6409 |
T9939 |
T9938 |
compound |
TACC2,protein |
R6410 |
T9941 |
T9942 |
det |
the,ability |
R6411 |
T9942 |
T9940 |
dobj |
ability,retains |
R6412 |
T9943 |
T9942 |
prep |
of,ability |
R6413 |
T9944 |
T9943 |
pobj |
TACC3,of |
R6414 |
T9945 |
T9946 |
aux |
to,interact |
R6415 |
T9946 |
T9942 |
acl |
interact,ability |
R6416 |
T9947 |
T9946 |
prep |
with,interact |
R6417 |
T9948 |
T9947 |
pobj |
GAS41,with |
R6418 |
T9949 |
T9948 |
punct |
", ",GAS41 |
R6419 |
T9950 |
T9948 |
conj |
INI1,GAS41 |
R6420 |
T9951 |
T9950 |
punct |
", ",INI1 |
R6421 |
T9952 |
T9953 |
compound |
histone,acetyltransferases |
R6422 |
T9953 |
T9950 |
conj |
acetyltransferases,INI1 |
R6423 |
T9954 |
T9953 |
cc |
and,acetyltransferases |
R6424 |
T9955 |
T9956 |
compound |
transcription,factors |
R6425 |
T9956 |
T9953 |
conj |
factors,acetyltransferases |
R6426 |
T9957 |
T9956 |
punct |
(,factors |
R6427 |
T9958 |
T9959 |
prep |
in,RXRβ |
R6428 |
T9959 |
T9956 |
appos |
RXRβ,factors |
R6429 |
T9960 |
T9961 |
det |
this,case |
R6430 |
T9961 |
T9958 |
pobj |
case,in |
R6431 |
T9962 |
T9959 |
punct |
", ",RXRβ |
R6432 |
T9963 |
T9956 |
punct |
),factors |
R6433 |
T9964 |
T9965 |
punct |
(,Fig. |
R6434 |
T9965 |
T9946 |
parataxis |
Fig.,interact |
R6435 |
T9966 |
T9965 |
nummod |
7,Fig. |
R6436 |
T9967 |
T9965 |
punct |
),Fig. |
R6437 |
T9968 |
T9969 |
punct |
[,34 |
R6438 |
T9969 |
T9946 |
parataxis |
34,interact |
R6439 |
T9970 |
T9969 |
nummod |
3,34 |
R6440 |
T9971 |
T9969 |
punct |
",",34 |
R6441 |
T9972 |
T9969 |
punct |
],34 |
R6442 |
T9973 |
T9940 |
punct |
.,retains |
R6443 |
T9975 |
T9976 |
advmod |
However,indicates |
R6444 |
T9977 |
T9976 |
punct |
", ",indicates |
R6445 |
T9978 |
T9979 |
det |
the,splicing |
R6446 |
T9979 |
T9976 |
nsubj |
splicing,indicates |
R6447 |
T9980 |
T9981 |
npadvmod |
tissue,specific |
R6448 |
T9981 |
T9979 |
amod |
specific,splicing |
R6449 |
T9982 |
T9979 |
prep |
of,splicing |
R6450 |
T9983 |
T9984 |
det |
the,exon |
R6451 |
T9984 |
T9982 |
pobj |
exon,of |
R6452 |
T9985 |
T9986 |
nummod |
5,kb |
R6453 |
T9986 |
T9984 |
compound |
kb,exon |
R6454 |
T9987 |
T9984 |
prep |
in,exon |
R6455 |
T9988 |
T9989 |
det |
the,isoform |
R6456 |
T9989 |
T9987 |
pobj |
isoform,in |
R6457 |
T9990 |
T9989 |
compound |
TACC2l,isoform |
R6458 |
T9991 |
T9992 |
punct |
[,3 |
R6459 |
T9992 |
T9979 |
parataxis |
3,splicing |
R6460 |
T9993 |
T9992 |
punct |
],3 |
R6461 |
T9994 |
T9995 |
mark |
that,has |
R6462 |
T9995 |
T9976 |
ccomp |
has,indicates |
R6463 |
T9996 |
T9997 |
det |
this,protein |
R6464 |
T9997 |
T9995 |
nsubj |
protein,has |
R6465 |
T9998 |
T9999 |
amod |
several,functions |
R6466 |
T9999 |
T9995 |
dobj |
functions,has |
R6467 |
T10000 |
T9999 |
amod |
temporal,functions |
R6468 |
T10001 |
T10000 |
cc |
and,temporal |
R6469 |
T10002 |
T10003 |
npadvmod |
tissue,specific |
R6470 |
T10003 |
T10000 |
conj |
specific,temporal |
R6471 |
T10004 |
T10005 |
advmod |
yet,identified |
R6472 |
T10005 |
T9999 |
advcl |
identified,functions |
R6473 |
T10006 |
T10005 |
aux |
to,identified |
R6474 |
T10007 |
T10005 |
auxpass |
be,identified |
R6475 |
T10008 |
T9976 |
punct |
.,indicates |
R5990 |
T9492 |
T9493 |
amod |
Proposed,evolution |
R5991 |
T9494 |
T9493 |
amod |
functional,evolution |
R5992 |
T9495 |
T9493 |
prep |
of,evolution |
R5993 |
T9496 |
T9497 |
det |
the,family |
R5994 |
T9497 |
T9495 |
pobj |
family,of |
R5995 |
T9498 |
T9497 |
compound |
TACC,family |
R5996 |
T9500 |
T9501 |
nsubj |
Examination,provides |
R5997 |
T9502 |
T9500 |
prep |
of,Examination |
R5998 |
T9503 |
T9504 |
det |
the,evolution |
R5999 |
T9504 |
T9502 |
pobj |
evolution,of |
R6000 |
T9505 |
T9504 |
prep |
of,evolution |
R6001 |
T9506 |
T9507 |
amod |
ancient,families |
R6002 |
T9507 |
T9505 |
pobj |
families,of |
R6003 |
T9508 |
T9507 |
compound |
gene,families |
R6004 |
T9509 |
T9510 |
det |
an,insight |
R6005 |
T9510 |
T9501 |
dobj |
insight,provides |
R6006 |
T9511 |
T9501 |
prep |
into,provides |
R6007 |
T9512 |
T9513 |
advmod |
how,relates |
R6008 |
T9513 |
T9511 |
pcomp |
relates,into |
R6009 |
T9514 |
T9515 |
compound |
gene,structure |
R6010 |
T9515 |
T9513 |
nsubj |
structure,relates |
R6011 |
T9516 |
T9513 |
prep |
to,relates |
R6012 |
T9517 |
T9516 |
pobj |
function,to |
R6013 |
T9518 |
T9501 |
punct |
.,provides |
R6014 |
T9520 |
T9521 |
nsubj |
We,presented |
R6015 |
T9522 |
T9521 |
aux |
have,presented |
R6016 |
T9523 |
T9521 |
advmod |
above,presented |
R6017 |
T9524 |
T9521 |
punct |
", ",presented |
R6018 |
T9525 |
T9526 |
det |
a,examination |
R6019 |
T9526 |
T9521 |
dobj |
examination,presented |
R6020 |
T9527 |
T9526 |
amod |
detailed,examination |
R6021 |
T9528 |
T9526 |
prep |
of,examination |
R6022 |
T9529 |
T9530 |
nummod |
one,family |
R6023 |
T9530 |
T9528 |
pobj |
family,of |
R6024 |
T9531 |
T9530 |
amod |
such,family |
R6025 |
T9532 |
T9530 |
compound |
gene,family |
R6026 |
T9533 |
T9521 |
punct |
.,presented |
R6027 |
T9535 |
T9536 |
det |
The,data |
R6028 |
T9536 |
T9537 |
nsubj |
data,suggest |
R6029 |
T9538 |
T9539 |
advmod |
so,far |
R6030 |
T9539 |
T9537 |
advmod |
far,suggest |
R6031 |
T9540 |
T9541 |
mark |
that,has |
R6032 |
T9541 |
T9537 |
ccomp |
has,suggest |
R6033 |
T9542 |
T9543 |
det |
the,homologue |
R6034 |
T9543 |
T9541 |
nsubj |
homologue,has |
R6035 |
T9544 |
T9543 |
amod |
functional,homologue |
R6036 |
T9545 |
T9543 |
compound |
TACC,homologue |
R6037 |
T9546 |
T9543 |
prep |
in,homologue |
R6038 |
T9547 |
T9546 |
pobj |
yeast,in |
R6039 |
T9548 |
T9543 |
punct |
(,homologue |
R6040 |
T9549 |
T9543 |
appos |
spc72,homologue |
R6041 |
T9550 |
T9543 |
punct |
),homologue |
R6042 |
T9551 |
T9552 |
det |
a,role |
R6043 |
T9552 |
T9541 |
dobj |
role,has |
R6044 |
T9553 |
T9552 |
amod |
specific,role |
R6045 |
T9554 |
T9552 |
prep |
in,role |
R6046 |
T9555 |
T9556 |
amod |
centrosomal,mitotic |
R6047 |
T9556 |
T9558 |
amod |
mitotic,spindle |
R6048 |
T9557 |
T9556 |
punct |
/,mitotic |
R6049 |
T9558 |
T9559 |
compound |
spindle,dynamics |
R6050 |
T9559 |
T9554 |
pobj |
dynamics,in |
R6051 |
T9560 |
T9561 |
punct |
[,22 |
R6052 |
T9561 |
T9537 |
parataxis |
22,suggest |
R6053 |
T9562 |
T9561 |
nummod |
21,22 |
R6054 |
T9563 |
T9561 |
punct |
",",22 |
R6055 |
T9564 |
T9561 |
punct |
],22 |
R6056 |
T9565 |
T9537 |
punct |
.,suggest |
R6057 |
T9567 |
T9568 |
det |
This,function |
R6058 |
T9568 |
T9571 |
nsubjpass |
function,conserved |
R6059 |
T9569 |
T9568 |
amod |
ancient,function |
R6060 |
T9570 |
T9568 |
compound |
TACC,function |
R6061 |
T9572 |
T9571 |
auxpass |
is,conserved |
R6062 |
T9573 |
T9571 |
prep |
throughout,conserved |
R6063 |
T9574 |
T9573 |
pobj |
evolution,throughout |
R6064 |
T9575 |
T9571 |
prep |
in,conserved |
R6065 |
T9576 |
T9577 |
preconj |
both,protostomes |
R6066 |
T9577 |
T9575 |
pobj |
protostomes,in |
R6067 |
T9578 |
T9577 |
cc |
and,protostomes |
R6068 |
T9579 |
T9577 |
conj |
deuterostomes,protostomes |
R6069 |
T9580 |
T9571 |
punct |
.,conserved |
R6070 |
T9582 |
T9583 |
prep |
In,appear |
R6071 |
T9584 |
T9582 |
pobj |
addition,In |
R6072 |
T9585 |
T9583 |
punct |
", ",appear |
R6073 |
T9586 |
T9587 |
det |
the,proteins |
R6074 |
T9587 |
T9583 |
nsubj |
proteins,appear |
R6075 |
T9588 |
T9587 |
compound |
TACC,proteins |
R6076 |
T9589 |
T9587 |
prep |
of,proteins |
R6077 |
T9590 |
T9591 |
amod |
lower,organisms |
R6078 |
T9591 |
T9589 |
pobj |
organisms,of |
R6079 |
T9592 |
T9593 |
aux |
to,interact |
R6080 |
T9593 |
T9583 |
xcomp |
interact,appear |
R6081 |
T9594 |
T9593 |
prep |
with,interact |
R6082 |
T9595 |
T9596 |
compound |
bridging,proteins |
R6083 |
T9596 |
T9594 |
pobj |
proteins,with |
R6084 |
T9597 |
T9598 |
dep |
that,are |
R6085 |
T9598 |
T9596 |
relcl |
are,proteins |
R6086 |
T9599 |
T9598 |
attr |
components,are |
R6087 |
T9600 |
T9599 |
prep |
of,components |
R6088 |
T9601 |
T9602 |
amod |
several,complexes |
R6089 |
T9602 |
T9600 |
pobj |
complexes,of |
R6090 |
T9603 |
T9602 |
amod |
different,complexes |
R6091 |
T9604 |
T9602 |
compound |
protein,complexes |
R6092 |
T9605 |
T9602 |
acl |
involved,complexes |
R6093 |
T9606 |
T9605 |
prep |
in,involved |
R6094 |
T9607 |
T9608 |
compound |
DNA,damage |
R6095 |
T9608 |
T9609 |
compound |
damage,repair |
R6096 |
T9609 |
T9606 |
pobj |
repair,in |
R6097 |
T9610 |
T9609 |
punct |
", ",repair |
R6098 |
T9611 |
T9612 |
compound |
protein,translation |
R6099 |
T9612 |
T9609 |
appos |
translation,repair |
R6100 |
T9613 |
T9609 |
punct |
", ",repair |
R6101 |
T9614 |
T9615 |
compound |
RNA,processing |
R6102 |
T9615 |
T9609 |
appos |
processing,repair |
R6103 |
T9616 |
T9615 |
cc |
and,processing |
R6104 |
T9617 |
T9615 |
conj |
transcription,processing |
R6105 |
T9618 |
T9583 |
punct |
.,appear |
R6106 |
T9620 |
T9621 |
advmod |
However,acquired |
R6107 |
T9622 |
T9621 |
punct |
", ",acquired |
R6108 |
T9623 |
T9621 |
prep |
over,acquired |
R6109 |
T9624 |
T9625 |
det |
the,process |
R6110 |
T9625 |
T9623 |
pobj |
process,over |
R6111 |
T9626 |
T9625 |
prep |
of,process |
R6112 |
T9627 |
T9628 |
amod |
evolutionary,time |
R6113 |
T9628 |
T9626 |
pobj |
time,of |
R6114 |
T9629 |
T9621 |
punct |
", ",acquired |
R6115 |
T9630 |
T9621 |
prep |
with,acquired |
R6116 |
T9631 |
T9632 |
det |
the,acquisition |
R6117 |
T9632 |
T9630 |
pobj |
acquisition,with |
R6118 |
T9633 |
T9632 |
prep |
of,acquisition |
R6119 |
T9634 |
T9635 |
amod |
new,domains |
R6120 |
T9635 |
T9633 |
pobj |
domains,of |
R6121 |
T9636 |
T9635 |
cc |
and,domains |
R6122 |
T9637 |
T9635 |
conj |
duplication,domains |
R6123 |
T9638 |
T9637 |
prep |
of,duplication |
R6124 |
T9639 |
T9640 |
det |
the,precursor |
R6125 |
T9640 |
T9638 |
pobj |
precursor,of |
R6126 |
T9641 |
T9640 |
compound |
chordate,precursor |
R6127 |
T9642 |
T9640 |
compound |
TACC,precursor |
R6128 |
T9643 |
T9621 |
punct |
", ",acquired |
R6129 |
T9644 |
T9645 |
det |
the,proteins |
R6130 |
T9645 |
T9621 |
nsubj |
proteins,acquired |
R6131 |
T9646 |
T9645 |
compound |
chordate,proteins |
R6132 |
T9647 |
T9645 |
compound |
TACC,proteins |
R6133 |
T9648 |
T9621 |
aux |
have,acquired |
R6134 |
T9649 |
T9650 |
det |
the,ability |
R6135 |
T9650 |
T9621 |
dobj |
ability,acquired |
R6136 |
T9651 |
T9652 |
aux |
to,interact |
R6137 |
T9652 |
T9650 |
acl |
interact,ability |
R6138 |
T9653 |
T9652 |
advmod |
directly,interact |
R6139 |
T9654 |
T9652 |
prep |
with,interact |
R6140 |
T9655 |
T9654 |
pobj |
some,with |
R6141 |
T9656 |
T9655 |
prep |
of,some |
R6142 |
T9657 |
T9658 |
det |
the,components |
R6143 |
T9658 |
T9656 |
pobj |
components,of |
R6144 |
T9659 |
T9658 |
amod |
other,components |
R6145 |
T9660 |
T9658 |
prep |
of,components |
R6146 |
T9661 |
T9662 |
det |
these,complexes |
R6147 |
T9662 |
T9660 |
pobj |
complexes,of |
R6148 |
T9663 |
T9655 |
punct |
(,some |
R6149 |
T9664 |
T9665 |
amod |
such,as |
R6150 |
T9665 |
T9655 |
prep |
as,some |
R6151 |
T9666 |
T9667 |
det |
the,proteins |
R6152 |
T9667 |
T9665 |
pobj |
proteins,as |
R6153 |
T9668 |
T9667 |
compound |
LSm,proteins |
R6154 |
T9669 |
T9667 |
punct |
", ",proteins |
R6155 |
T9670 |
T9671 |
amod |
nuclear,receptors |
R6156 |
T9671 |
T9667 |
conj |
receptors,proteins |
R6157 |
T9672 |
T9671 |
compound |
hormone,receptors |
R6158 |
T9673 |
T9671 |
punct |
", ",receptors |
R6159 |
T9674 |
T9671 |
conj |
GAS41,receptors |
R6160 |
T9675 |
T9674 |
punct |
", ",GAS41 |
R6161 |
T9676 |
T9677 |
amod |
accessory,proteins |
R6162 |
T9677 |
T9674 |
conj |
proteins,GAS41 |
R6163 |
T9678 |
T9677 |
cc |
and,proteins |
R6164 |
T9679 |
T9680 |
compound |
transcription,factors |
R6165 |
T9680 |
T9677 |
conj |
factors,proteins |
R6166 |
T9681 |
T9655 |
punct |
),some |
R6167 |
T9682 |
T9621 |
punct |
", ",acquired |
R6168 |
T9683 |
T9621 |
cc |
and,acquired |
R6169 |
T9684 |
T9685 |
advmod |
thus,evolved |
R6170 |
T9685 |
T9621 |
conj |
evolved,acquired |
R6171 |
T9686 |
T9687 |
amod |
additional,functions |
R6172 |
T9687 |
T9685 |
dobj |
functions,evolved |
R6173 |
T9688 |
T9685 |
prep |
within,evolved |
R6174 |
T9689 |
T9690 |
det |
these,complexes |
R6175 |
T9690 |
T9688 |
pobj |
complexes,within |
R6176 |
T9691 |
T9621 |
punct |
.,acquired |
R6177 |
T9693 |
T9694 |
advmod |
Indeed,was |
R6178 |
T9695 |
T9694 |
punct |
", ",was |
R6179 |
T9696 |
T9697 |
det |
the,function |
R6180 |
T9697 |
T9694 |
nsubj |
function,was |
R6181 |
T9698 |
T9697 |
amod |
first,function |
R6182 |
T9699 |
T9697 |
amod |
assigned,function |
R6183 |
T9700 |
T9697 |
prep |
of,function |
R6184 |
T9701 |
T9702 |
det |
a,protein |
R6185 |
T9702 |
T9700 |
pobj |
protein,of |
R6186 |
T9703 |
T9702 |
compound |
vertebrate,protein |
R6187 |
T9704 |
T9702 |
compound |
TACC,protein |
R6188 |
T9705 |
T9702 |
punct |
", ",protein |
R6189 |
T9706 |
T9707 |
compound |
mouse,TACC3 |
R6190 |
T9707 |
T9702 |
appos |
TACC3,protein |
R6191 |
T9708 |
T9694 |
punct |
", ",was |
R6192 |
T9709 |
T9694 |
prep |
as,was |
R6193 |
T9710 |
T9711 |
det |
a,coactivator |
R6194 |
T9711 |
T9709 |
pobj |
coactivator,as |
R6195 |
T9712 |
T9711 |
amod |
transcriptional,coactivator |
R6196 |
T9713 |
T9711 |
prep |
of,coactivator |
R6197 |
T9714 |
T9715 |
det |
the,response |
R6198 |
T9715 |
T9713 |
pobj |
response,of |
R6199 |
T9716 |
T9717 |
npadvmod |
ARNT,mediated |
R6200 |
T9717 |
T9715 |
amod |
mediated,response |
R6201 |
T9718 |
T9715 |
amod |
transcriptional,response |