Id |
Subject |
Object |
Predicate |
Lexical cue |
T9492 |
12-20 |
VBN |
denotes |
Proposed |
T9493 |
32-41 |
NN |
denotes |
evolution |
T9494 |
21-31 |
JJ |
denotes |
functional |
T9495 |
42-44 |
IN |
denotes |
of |
T9496 |
45-48 |
DT |
denotes |
the |
T9497 |
54-60 |
NN |
denotes |
family |
T9498 |
49-53 |
NN |
denotes |
TACC |
T9499 |
60-179 |
sentence |
denotes |
Examination of the evolution of ancient gene families provides an insight into how gene structure relates to function. |
T9500 |
61-72 |
NN |
denotes |
Examination |
T9501 |
115-123 |
VBZ |
denotes |
provides |
T9502 |
73-75 |
IN |
denotes |
of |
T9503 |
76-79 |
DT |
denotes |
the |
T9504 |
80-89 |
NN |
denotes |
evolution |
T9505 |
90-92 |
IN |
denotes |
of |
T9506 |
93-100 |
JJ |
denotes |
ancient |
T9507 |
106-114 |
NNS |
denotes |
families |
T9508 |
101-105 |
NN |
denotes |
gene |
T9509 |
124-126 |
DT |
denotes |
an |
T9510 |
127-134 |
NN |
denotes |
insight |
T9511 |
135-139 |
IN |
denotes |
into |
T9512 |
140-143 |
WRB |
denotes |
how |
T9513 |
159-166 |
VBZ |
denotes |
relates |
T9514 |
144-148 |
NN |
denotes |
gene |
T9515 |
149-158 |
NN |
denotes |
structure |
T9516 |
167-169 |
IN |
denotes |
to |
T9517 |
170-178 |
NN |
denotes |
function |
T9518 |
178-179 |
. |
denotes |
. |
T9519 |
179-252 |
sentence |
denotes |
We have presented above, a detailed examination of one such gene family. |
T9520 |
180-182 |
PRP |
denotes |
We |
T9521 |
188-197 |
VBN |
denotes |
presented |
T9522 |
183-187 |
VBP |
denotes |
have |
T9523 |
198-203 |
RB |
denotes |
above |
T9524 |
203-205 |
, |
denotes |
, |
T9525 |
205-206 |
DT |
denotes |
a |
T9526 |
216-227 |
NN |
denotes |
examination |
T9527 |
207-215 |
JJ |
denotes |
detailed |
T9528 |
228-230 |
IN |
denotes |
of |
T9529 |
231-234 |
CD |
denotes |
one |
T9530 |
245-251 |
NN |
denotes |
family |
T9531 |
235-239 |
JJ |
denotes |
such |
T9532 |
240-244 |
NN |
denotes |
gene |
T9533 |
251-252 |
. |
denotes |
. |
T9534 |
252-397 |
sentence |
denotes |
The data so far suggest that the functional TACC homologue in yeast (spc72) has a specific role in centrosomal/mitotic spindle dynamics [21,22]. |
T9535 |
253-256 |
DT |
denotes |
The |
T9536 |
257-261 |
NNS |
denotes |
data |
T9537 |
269-276 |
VBP |
denotes |
suggest |
T9538 |
262-264 |
RB |
denotes |
so |
T9539 |
265-268 |
RB |
denotes |
far |
T9540 |
277-281 |
IN |
denotes |
that |
T9541 |
329-332 |
VBZ |
denotes |
has |
T9542 |
282-285 |
DT |
denotes |
the |
T9543 |
302-311 |
NN |
denotes |
homologue |
T9544 |
286-296 |
JJ |
denotes |
functional |
T9545 |
297-301 |
NN |
denotes |
TACC |
T9546 |
312-314 |
IN |
denotes |
in |
T9547 |
315-320 |
NN |
denotes |
yeast |
T9548 |
321-322 |
-LRB- |
denotes |
( |
T9549 |
322-327 |
NN |
denotes |
spc72 |
T9550 |
327-328 |
-RRB- |
denotes |
) |
T9551 |
333-334 |
DT |
denotes |
a |
T9552 |
344-348 |
NN |
denotes |
role |
T9553 |
335-343 |
JJ |
denotes |
specific |
T9554 |
349-351 |
IN |
denotes |
in |
T9555 |
352-363 |
JJ |
denotes |
centrosomal |
T9556 |
364-371 |
JJ |
denotes |
mitotic |
T9557 |
363-364 |
HYPH |
denotes |
/ |
T9558 |
372-379 |
NN |
denotes |
spindle |
T9559 |
380-388 |
NNS |
denotes |
dynamics |
T9560 |
389-390 |
-LRB- |
denotes |
[ |
T9561 |
393-395 |
CD |
denotes |
22 |
T9562 |
390-392 |
CD |
denotes |
21 |
T9563 |
392-393 |
, |
denotes |
, |
T9564 |
395-396 |
-RRB- |
denotes |
] |
T9565 |
396-397 |
. |
denotes |
. |
T9566 |
397-497 |
sentence |
denotes |
This ancient TACC function is conserved throughout evolution in both protostomes and deuterostomes. |
T9567 |
398-402 |
DT |
denotes |
This |
T9568 |
416-424 |
NN |
denotes |
function |
T9569 |
403-410 |
JJ |
denotes |
ancient |
T9570 |
411-415 |
NN |
denotes |
TACC |
T9571 |
428-437 |
VBN |
denotes |
conserved |
T9572 |
425-427 |
VBZ |
denotes |
is |
T9573 |
438-448 |
IN |
denotes |
throughout |
T9574 |
449-458 |
NN |
denotes |
evolution |
T9575 |
459-461 |
IN |
denotes |
in |
T9576 |
462-466 |
CC |
denotes |
both |
T9577 |
467-478 |
NNS |
denotes |
protostomes |
T9578 |
479-482 |
CC |
denotes |
and |
T9579 |
483-496 |
NNS |
denotes |
deuterostomes |
T9580 |
496-497 |
. |
denotes |
. |
T9581 |
497-734 |
sentence |
denotes |
In addition, the TACC proteins of lower organisms appear to interact with bridging proteins that are components of several different protein complexes involved in DNA damage repair, protein translation, RNA processing and transcription. |
T9582 |
498-500 |
IN |
denotes |
In |
T9583 |
548-554 |
VBP |
denotes |
appear |
T9584 |
501-509 |
NN |
denotes |
addition |
T9585 |
509-511 |
, |
denotes |
, |
T9586 |
511-514 |
DT |
denotes |
the |
T9587 |
520-528 |
NN |
denotes |
proteins |
T9588 |
515-519 |
NN |
denotes |
TACC |
T9589 |
529-531 |
IN |
denotes |
of |
T9590 |
532-537 |
JJR |
denotes |
lower |
T9591 |
538-547 |
NNS |
denotes |
organisms |
T9592 |
555-557 |
TO |
denotes |
to |
T9593 |
558-566 |
VB |
denotes |
interact |
T9594 |
567-571 |
IN |
denotes |
with |
T9595 |
572-580 |
NN |
denotes |
bridging |
T9596 |
581-589 |
NN |
denotes |
proteins |
T9597 |
590-594 |
WDT |
denotes |
that |
T9598 |
595-598 |
VBP |
denotes |
are |
T9599 |
599-609 |
NNS |
denotes |
components |
T9600 |
610-612 |
IN |
denotes |
of |
T9601 |
613-620 |
JJ |
denotes |
several |
T9602 |
639-648 |
NNS |
denotes |
complexes |
T9603 |
621-630 |
JJ |
denotes |
different |
T9604 |
631-638 |
NN |
denotes |
protein |
T9605 |
649-657 |
VBN |
denotes |
involved |
T9606 |
658-660 |
IN |
denotes |
in |
T9607 |
661-664 |
NN |
denotes |
DNA |
T9608 |
665-671 |
NN |
denotes |
damage |
T9609 |
672-678 |
NN |
denotes |
repair |
T9610 |
678-680 |
, |
denotes |
, |
T9611 |
680-687 |
NN |
denotes |
protein |
T9612 |
688-699 |
NN |
denotes |
translation |
T9613 |
699-701 |
, |
denotes |
, |
T9614 |
701-704 |
NN |
denotes |
RNA |
T9615 |
705-715 |
NN |
denotes |
processing |
T9616 |
716-719 |
CC |
denotes |
and |
T9617 |
720-733 |
NN |
denotes |
transcription |
T9618 |
733-734 |
. |
denotes |
. |
T9619 |
734-1163 |
sentence |
denotes |
However, over the process of evolutionary time, with the acquisition of new domains and duplication of the chordate TACC precursor, the chordate TACC proteins have acquired the ability to directly interact with some of the other components of these complexes (such as the LSm proteins, nuclear hormone receptors, GAS41, accessory proteins and transcription factors), and thus evolved additional functions within these complexes. |
T9620 |
735-742 |
RB |
denotes |
However |
T9621 |
899-907 |
VBN |
denotes |
acquired |
T9622 |
742-744 |
, |
denotes |
, |
T9623 |
744-748 |
IN |
denotes |
over |
T9624 |
749-752 |
DT |
denotes |
the |
T9625 |
753-760 |
NN |
denotes |
process |
T9626 |
761-763 |
IN |
denotes |
of |
T9627 |
764-776 |
JJ |
denotes |
evolutionary |
T9628 |
777-781 |
NN |
denotes |
time |
T9629 |
781-783 |
, |
denotes |
, |
T9630 |
783-787 |
IN |
denotes |
with |
T9631 |
788-791 |
DT |
denotes |
the |
T9632 |
792-803 |
NN |
denotes |
acquisition |
T9633 |
804-806 |
IN |
denotes |
of |
T9634 |
807-810 |
JJ |
denotes |
new |
T9635 |
811-818 |
NNS |
denotes |
domains |
T9636 |
819-822 |
CC |
denotes |
and |
T9637 |
823-834 |
NN |
denotes |
duplication |
T9638 |
835-837 |
IN |
denotes |
of |
T9639 |
838-841 |
DT |
denotes |
the |
T9640 |
856-865 |
NN |
denotes |
precursor |
T9641 |
842-850 |
NN |
denotes |
chordate |
T9642 |
851-855 |
NN |
denotes |
TACC |
T9643 |
865-867 |
, |
denotes |
, |
T9644 |
867-870 |
DT |
denotes |
the |
T9645 |
885-893 |
NN |
denotes |
proteins |
T9646 |
871-879 |
NN |
denotes |
chordate |
T9647 |
880-884 |
NN |
denotes |
TACC |
T9648 |
894-898 |
VBP |
denotes |
have |
T9649 |
908-911 |
DT |
denotes |
the |
T9650 |
912-919 |
NN |
denotes |
ability |
T9651 |
920-922 |
TO |
denotes |
to |
T9652 |
932-940 |
VB |
denotes |
interact |
T9653 |
923-931 |
RB |
denotes |
directly |
T9654 |
941-945 |
IN |
denotes |
with |
T9655 |
946-950 |
DT |
denotes |
some |
T9656 |
951-953 |
IN |
denotes |
of |
T9657 |
954-957 |
DT |
denotes |
the |
T9658 |
964-974 |
NNS |
denotes |
components |
T9659 |
958-963 |
JJ |
denotes |
other |
T9660 |
975-977 |
IN |
denotes |
of |
T9661 |
978-983 |
DT |
denotes |
these |
T9662 |
984-993 |
NNS |
denotes |
complexes |
T9663 |
994-995 |
-LRB- |
denotes |
( |
T9664 |
995-999 |
JJ |
denotes |
such |
T9665 |
1000-1002 |
IN |
denotes |
as |
T9666 |
1003-1006 |
DT |
denotes |
the |
T9667 |
1011-1019 |
NN |
denotes |
proteins |
T9668 |
1007-1010 |
NN |
denotes |
LSm |
T9669 |
1019-1021 |
, |
denotes |
, |
T9670 |
1021-1028 |
JJ |
denotes |
nuclear |
T9671 |
1037-1046 |
NNS |
denotes |
receptors |
T9672 |
1029-1036 |
NN |
denotes |
hormone |
T9673 |
1046-1048 |
, |
denotes |
, |
T9674 |
1048-1053 |
NN |
denotes |
GAS41 |
T9675 |
1053-1055 |
, |
denotes |
, |
T9676 |
1055-1064 |
JJ |
denotes |
accessory |
T9677 |
1065-1073 |
NN |
denotes |
proteins |
T9678 |
1074-1077 |
CC |
denotes |
and |
T9679 |
1078-1091 |
NN |
denotes |
transcription |
T9680 |
1092-1099 |
NNS |
denotes |
factors |
T9681 |
1099-1100 |
-RRB- |
denotes |
) |
T9682 |
1100-1102 |
, |
denotes |
, |
T9683 |
1102-1105 |
CC |
denotes |
and |
T9684 |
1106-1110 |
RB |
denotes |
thus |
T9685 |
1111-1118 |
VBD |
denotes |
evolved |
T9686 |
1119-1129 |
JJ |
denotes |
additional |
T9687 |
1130-1139 |
NNS |
denotes |
functions |
T9688 |
1140-1146 |
IN |
denotes |
within |
T9689 |
1147-1152 |
DT |
denotes |
these |
T9690 |
1153-1162 |
NNS |
denotes |
complexes |
T9691 |
1162-1163 |
. |
denotes |
. |
T9692 |
1163-1371 |
sentence |
denotes |
Indeed, the first assigned function of a vertebrate TACC protein, mouse TACC3, was as a transcriptional coactivator of the ARNT mediated transcriptional response to hypoxia and polyaromatic hydrocarbons [7]. |
T9693 |
1164-1170 |
RB |
denotes |
Indeed |
T9694 |
1243-1246 |
VBD |
denotes |
was |
T9695 |
1170-1172 |
, |
denotes |
, |
T9696 |
1172-1175 |
DT |
denotes |
the |
T9697 |
1191-1199 |
NN |
denotes |
function |
T9698 |
1176-1181 |
JJ |
denotes |
first |
T9699 |
1182-1190 |
VBN |
denotes |
assigned |
T9700 |
1200-1202 |
IN |
denotes |
of |
T9701 |
1203-1204 |
DT |
denotes |
a |
T9702 |
1221-1228 |
NN |
denotes |
protein |
T9703 |
1205-1215 |
NN |
denotes |
vertebrate |
T9704 |
1216-1220 |
NN |
denotes |
TACC |
T9705 |
1228-1230 |
, |
denotes |
, |
T9706 |
1230-1235 |
NN |
denotes |
mouse |
T9707 |
1236-1241 |
NN |
denotes |
TACC3 |
T9708 |
1241-1243 |
, |
denotes |
, |
T9709 |
1247-1249 |
IN |
denotes |
as |
T9710 |
1250-1251 |
DT |
denotes |
a |
T9711 |
1268-1279 |
NN |
denotes |
coactivator |
T9712 |
1252-1267 |
JJ |
denotes |
transcriptional |
T9713 |
1280-1282 |
IN |
denotes |
of |
T9714 |
1283-1286 |
DT |
denotes |
the |
T9715 |
1317-1325 |
NN |
denotes |
response |
T9716 |
1287-1291 |
NN |
denotes |
ARNT |
T9717 |
1292-1300 |
VBN |
denotes |
mediated |
T9718 |
1301-1316 |
JJ |
denotes |
transcriptional |
T9719 |
1326-1328 |
IN |
denotes |
to |
T9720 |
1329-1336 |
NN |
denotes |
hypoxia |
T9721 |
1337-1340 |
CC |
denotes |
and |
T9722 |
1341-1353 |
JJ |
denotes |
polyaromatic |
T9723 |
1354-1366 |
NNS |
denotes |
hydrocarbons |
T9724 |
1367-1368 |
-LRB- |
denotes |
[ |
T9725 |
1368-1369 |
CD |
denotes |
7 |
T9726 |
1369-1370 |
-RRB- |
denotes |
] |
T9727 |
1370-1371 |
. |
denotes |
. |
T9728 |
1371-1460 |
sentence |
denotes |
Mouse TACC3 has also been reported to interact with the transcription factor STAT5 [33]. |
T9729 |
1372-1377 |
NN |
denotes |
Mouse |
T9730 |
1378-1383 |
NN |
denotes |
TACC3 |
T9731 |
1398-1406 |
VBN |
denotes |
reported |
T9732 |
1384-1387 |
VBZ |
denotes |
has |
T9733 |
1388-1392 |
RB |
denotes |
also |
T9734 |
1393-1397 |
VBN |
denotes |
been |
T9735 |
1407-1409 |
TO |
denotes |
to |
T9736 |
1410-1418 |
VB |
denotes |
interact |
T9737 |
1419-1423 |
IN |
denotes |
with |
T9738 |
1424-1427 |
DT |
denotes |
the |
T9739 |
1449-1454 |
NN |
denotes |
STAT5 |
T9740 |
1428-1441 |
NN |
denotes |
transcription |
T9741 |
1442-1448 |
NN |
denotes |
factor |
T9742 |
1455-1456 |
-LRB- |
denotes |
[ |
T9743 |
1456-1458 |
CD |
denotes |
33 |
T9744 |
1458-1459 |
-RRB- |
denotes |
] |
T9745 |
1459-1460 |
. |
denotes |
. |
T9746 |
1460-1677 |
sentence |
denotes |
Recently, we have demonstrated that TACC2 and TACC3 can bind to nuclear histone acetyltransferases [34], further confirming a more direct role for the TACC proteins in transcriptional and chromatin remodeling events. |
T9747 |
1461-1469 |
RB |
denotes |
Recently |
T9748 |
1479-1491 |
VBN |
denotes |
demonstrated |
T9749 |
1469-1471 |
, |
denotes |
, |
T9750 |
1471-1473 |
PRP |
denotes |
we |
T9751 |
1474-1478 |
VBP |
denotes |
have |
T9752 |
1492-1496 |
IN |
denotes |
that |
T9753 |
1517-1521 |
VB |
denotes |
bind |
T9754 |
1497-1502 |
NN |
denotes |
TACC2 |
T9755 |
1503-1506 |
CC |
denotes |
and |
T9756 |
1507-1512 |
NN |
denotes |
TACC3 |
T9757 |
1513-1516 |
MD |
denotes |
can |
T9758 |
1522-1524 |
IN |
denotes |
to |
T9759 |
1525-1532 |
JJ |
denotes |
nuclear |
T9760 |
1541-1559 |
NNS |
denotes |
acetyltransferases |
T9761 |
1533-1540 |
NN |
denotes |
histone |
T9762 |
1560-1561 |
-LRB- |
denotes |
[ |
T9763 |
1561-1563 |
CD |
denotes |
34 |
T9764 |
1563-1564 |
-RRB- |
denotes |
] |
T9765 |
1564-1566 |
, |
denotes |
, |
T9766 |
1566-1573 |
RB |
denotes |
further |
T9767 |
1574-1584 |
VBG |
denotes |
confirming |
T9768 |
1585-1586 |
DT |
denotes |
a |
T9769 |
1599-1603 |
NN |
denotes |
role |
T9770 |
1587-1591 |
RBR |
denotes |
more |
T9771 |
1592-1598 |
JJ |
denotes |
direct |
T9772 |
1604-1607 |
IN |
denotes |
for |
T9773 |
1608-1611 |
DT |
denotes |
the |
T9774 |
1617-1625 |
NN |
denotes |
proteins |
T9775 |
1612-1616 |
NN |
denotes |
TACC |
T9776 |
1626-1628 |
IN |
denotes |
in |
T9777 |
1629-1644 |
JJ |
denotes |
transcriptional |
T9778 |
1670-1676 |
NNS |
denotes |
events |
T9779 |
1645-1648 |
CC |
denotes |
and |
T9780 |
1649-1658 |
NN |
denotes |
chromatin |
T9781 |
1659-1669 |
NN |
denotes |
remodeling |
T9782 |
1676-1677 |
. |
denotes |
. |
T9783 |
1677-1904 |
sentence |
denotes |
Interestingly although all human TACC proteins can directly interact with the histone acetyltransferase pCAF in vitro, the TACC1 isoforms expressed in human breast cancer cells do not interact with this histone acetylase [34]. |
T9784 |
1678-1691 |
RB |
denotes |
Interestingly |
T9785 |
1862-1870 |
VB |
denotes |
interact |
T9786 |
1692-1700 |
IN |
denotes |
although |
T9787 |
1738-1746 |
VB |
denotes |
interact |
T9788 |
1701-1704 |
DT |
denotes |
all |
T9789 |
1716-1724 |
NN |
denotes |
proteins |
T9790 |
1705-1710 |
JJ |
denotes |
human |
T9791 |
1711-1715 |
NN |
denotes |
TACC |
T9792 |
1725-1728 |
MD |
denotes |
can |
T9793 |
1729-1737 |
RB |
denotes |
directly |
T9794 |
1747-1751 |
IN |
denotes |
with |
T9795 |
1752-1755 |
DT |
denotes |
the |
T9796 |
1764-1781 |
NN |
denotes |
acetyltransferase |
T9797 |
1756-1763 |
NN |
denotes |
histone |
T9798 |
1782-1786 |
NN |
denotes |
pCAF |
T9799 |
1787-1789 |
FW |
denotes |
in |
T9800 |
1790-1795 |
FW |
denotes |
vitro |
T9801 |
1795-1797 |
, |
denotes |
, |
T9802 |
1797-1800 |
DT |
denotes |
the |
T9803 |
1807-1815 |
NNS |
denotes |
isoforms |
T9804 |
1801-1806 |
NN |
denotes |
TACC1 |
T9805 |
1816-1825 |
VBN |
denotes |
expressed |
T9806 |
1826-1828 |
IN |
denotes |
in |
T9807 |
1829-1834 |
JJ |
denotes |
human |
T9808 |
1849-1854 |
NNS |
denotes |
cells |
T9809 |
1835-1841 |
NN |
denotes |
breast |
T9810 |
1842-1848 |
NN |
denotes |
cancer |
T9811 |
1855-1857 |
VBP |
denotes |
do |
T9812 |
1858-1861 |
RB |
denotes |
not |
T9813 |
1871-1875 |
IN |
denotes |
with |
T9814 |
1876-1880 |
DT |
denotes |
this |
T9815 |
1889-1898 |
NN |
denotes |
acetylase |
T9816 |
1881-1888 |
NN |
denotes |
histone |
T9817 |
1899-1900 |
-LRB- |
denotes |
[ |
T9818 |
1900-1902 |
CD |
denotes |
34 |
T9819 |
1902-1903 |
-RRB- |
denotes |
] |
T9820 |
1903-1904 |
. |
denotes |
. |
T9821 |
1904-2058 |
sentence |
denotes |
This may be attributable to the proposed function of the Exon 1 containing TACC1 variants in RNA processing, via the interaction with LSm-7 and SmG [19]. |
T9822 |
1905-1909 |
DT |
denotes |
This |
T9823 |
1914-1916 |
VB |
denotes |
be |
T9824 |
1910-1913 |
MD |
denotes |
may |
T9825 |
1917-1929 |
JJ |
denotes |
attributable |
T9826 |
1930-1932 |
IN |
denotes |
to |
T9827 |
1933-1936 |
DT |
denotes |
the |
T9828 |
1946-1954 |
NN |
denotes |
function |
T9829 |
1937-1945 |
VBN |
denotes |
proposed |
T9830 |
1955-1957 |
IN |
denotes |
of |
T9831 |
1958-1961 |
DT |
denotes |
the |
T9832 |
1986-1994 |
NNS |
denotes |
variants |
T9833 |
1962-1966 |
NN |
denotes |
Exon |
T9834 |
1969-1979 |
VBG |
denotes |
containing |
T9835 |
1967-1968 |
CD |
denotes |
1 |
T9836 |
1980-1985 |
NN |
denotes |
TACC1 |
T9837 |
1995-1997 |
IN |
denotes |
in |
T9838 |
1998-2001 |
NN |
denotes |
RNA |
T9839 |
2002-2012 |
NN |
denotes |
processing |
T9840 |
2012-2014 |
, |
denotes |
, |
T9841 |
2014-2017 |
IN |
denotes |
via |
T9842 |
2018-2021 |
DT |
denotes |
the |
T9843 |
2022-2033 |
NN |
denotes |
interaction |
T9844 |
2034-2038 |
IN |
denotes |
with |
T9845 |
2039-2042 |
NN |
denotes |
LSm |
T9846 |
2042-2043 |
HYPH |
denotes |
- |
T9847 |
2043-2044 |
CD |
denotes |
7 |
T9848 |
2045-2048 |
CC |
denotes |
and |
T9849 |
2049-2052 |
NN |
denotes |
SmG |
T9850 |
2053-2054 |
-LRB- |
denotes |
[ |
T9851 |
2054-2056 |
CD |
denotes |
19 |
T9852 |
2056-2057 |
-RRB- |
denotes |
] |
T9853 |
2057-2058 |
. |
denotes |
. |
T9854 |
2058-2385 |
sentence |
denotes |
Thus, alternative splicing of the TACC1 gene adds further diversity to TACC1 function, as the deletion of specific exons and their associated binding domains will change the potential protein complexes with which they can associate, either directly, or by redirecting the splice variants to different subcellular compartments. |
T9855 |
2059-2063 |
RB |
denotes |
Thus |
T9856 |
2104-2108 |
VBZ |
denotes |
adds |
T9857 |
2063-2065 |
, |
denotes |
, |
T9858 |
2065-2076 |
JJ |
denotes |
alternative |
T9859 |
2077-2085 |
NN |
denotes |
splicing |
T9860 |
2086-2088 |
IN |
denotes |
of |
T9861 |
2089-2092 |
DT |
denotes |
the |
T9862 |
2099-2103 |
NN |
denotes |
gene |
T9863 |
2093-2098 |
NN |
denotes |
TACC1 |
T9864 |
2109-2116 |
JJ |
denotes |
further |
T9865 |
2117-2126 |
NN |
denotes |
diversity |
T9866 |
2127-2129 |
IN |
denotes |
to |
T9867 |
2130-2135 |
NN |
denotes |
TACC1 |
T9868 |
2136-2144 |
NN |
denotes |
function |
T9869 |
2144-2146 |
, |
denotes |
, |
T9870 |
2146-2148 |
IN |
denotes |
as |
T9871 |
2222-2228 |
VB |
denotes |
change |
T9872 |
2149-2152 |
DT |
denotes |
the |
T9873 |
2153-2161 |
NN |
denotes |
deletion |
T9874 |
2162-2164 |
IN |
denotes |
of |
T9875 |
2165-2173 |
JJ |
denotes |
specific |
T9876 |
2174-2179 |
NNS |
denotes |
exons |
T9877 |
2180-2183 |
CC |
denotes |
and |
T9878 |
2184-2189 |
PRP$ |
denotes |
their |
T9879 |
2209-2216 |
NNS |
denotes |
domains |
T9880 |
2190-2200 |
VBN |
denotes |
associated |
T9881 |
2201-2208 |
NN |
denotes |
binding |
T9882 |
2217-2221 |
MD |
denotes |
will |
T9883 |
2229-2232 |
DT |
denotes |
the |
T9884 |
2251-2260 |
NNS |
denotes |
complexes |
T9885 |
2233-2242 |
JJ |
denotes |
potential |
T9886 |
2243-2250 |
NN |
denotes |
protein |
T9887 |
2261-2265 |
IN |
denotes |
with |
T9888 |
2281-2290 |
VB |
denotes |
associate |
T9889 |
2266-2271 |
WDT |
denotes |
which |
T9890 |
2272-2276 |
PRP |
denotes |
they |
T9891 |
2277-2280 |
MD |
denotes |
can |
T9892 |
2290-2292 |
, |
denotes |
, |
T9893 |
2292-2298 |
CC |
denotes |
either |
T9894 |
2312-2314 |
IN |
denotes |
by |
T9895 |
2299-2307 |
RB |
denotes |
directly |
T9896 |
2307-2309 |
, |
denotes |
, |
T9897 |
2309-2311 |
CC |
denotes |
or |
T9898 |
2315-2326 |
VBG |
denotes |
redirecting |
T9899 |
2327-2330 |
DT |
denotes |
the |
T9900 |
2338-2346 |
NNS |
denotes |
variants |
T9901 |
2331-2337 |
NN |
denotes |
splice |
T9902 |
2347-2349 |
IN |
denotes |
to |
T9903 |
2350-2359 |
JJ |
denotes |
different |
T9904 |
2372-2384 |
NNS |
denotes |
compartments |
T9905 |
2360-2371 |
JJ |
denotes |
subcellular |
T9906 |
2384-2385 |
. |
denotes |
. |
T9907 |
2385-2539 |
sentence |
denotes |
With the duplication of the TACC1/TACC2 ancestor, it is apparent that an even greater functional diversity may have been introduced into the TACC family. |
T9908 |
2386-2390 |
IN |
denotes |
With |
T9909 |
2439-2441 |
VBZ |
denotes |
is |
T9910 |
2391-2394 |
DT |
denotes |
the |
T9911 |
2395-2406 |
NN |
denotes |
duplication |
T9912 |
2407-2409 |
IN |
denotes |
of |
T9913 |
2410-2413 |
DT |
denotes |
the |
T9914 |
2426-2434 |
NN |
denotes |
ancestor |
T9915 |
2414-2419 |
NN |
denotes |
TACC1 |
T9916 |
2420-2425 |
NN |
denotes |
TACC2 |
T9917 |
2419-2420 |
HYPH |
denotes |
/ |
T9918 |
2434-2436 |
, |
denotes |
, |
T9919 |
2436-2438 |
PRP |
denotes |
it |
T9920 |
2442-2450 |
JJ |
denotes |
apparent |
T9921 |
2451-2455 |
IN |
denotes |
that |
T9922 |
2507-2517 |
VBN |
denotes |
introduced |
T9923 |
2456-2458 |
DT |
denotes |
an |
T9924 |
2483-2492 |
NN |
denotes |
diversity |
T9925 |
2459-2463 |
RB |
denotes |
even |
T9926 |
2464-2471 |
JJR |
denotes |
greater |
T9927 |
2472-2482 |
JJ |
denotes |
functional |
T9928 |
2493-2496 |
MD |
denotes |
may |
T9929 |
2497-2501 |
VB |
denotes |
have |
T9930 |
2502-2506 |
VBN |
denotes |
been |
T9931 |
2518-2522 |
IN |
denotes |
into |
T9932 |
2523-2526 |
DT |
denotes |
the |
T9933 |
2532-2538 |
NN |
denotes |
family |
T9934 |
2527-2531 |
NN |
denotes |
TACC |
T9935 |
2538-2539 |
. |
denotes |
. |
T9936 |
2539-2707 |
sentence |
denotes |
The TACC2 protein retains the ability of TACC3 to interact with GAS41, INI1, histone acetyltransferases and transcription factors (in this case, RXRβ) (Fig. 7) [3,34]. |
T9937 |
2540-2543 |
DT |
denotes |
The |
T9938 |
2550-2557 |
NN |
denotes |
protein |
T9939 |
2544-2549 |
NN |
denotes |
TACC2 |
T9940 |
2558-2565 |
VBZ |
denotes |
retains |
T9941 |
2566-2569 |
DT |
denotes |
the |
T9942 |
2570-2577 |
NN |
denotes |
ability |
T9943 |
2578-2580 |
IN |
denotes |
of |
T9944 |
2581-2586 |
NN |
denotes |
TACC3 |
T9945 |
2587-2589 |
TO |
denotes |
to |
T9946 |
2590-2598 |
VB |
denotes |
interact |
T9947 |
2599-2603 |
IN |
denotes |
with |
T9948 |
2604-2609 |
NN |
denotes |
GAS41 |
T9949 |
2609-2611 |
, |
denotes |
, |
T9950 |
2611-2615 |
NN |
denotes |
INI1 |
T9951 |
2615-2617 |
, |
denotes |
, |
T9952 |
2617-2624 |
NN |
denotes |
histone |
T9953 |
2625-2643 |
NNS |
denotes |
acetyltransferases |
T9954 |
2644-2647 |
CC |
denotes |
and |
T9955 |
2648-2661 |
NN |
denotes |
transcription |
T9956 |
2662-2669 |
NNS |
denotes |
factors |
T9957 |
2670-2671 |
-LRB- |
denotes |
( |
T9958 |
2671-2673 |
IN |
denotes |
in |
T9959 |
2685-2689 |
NN |
denotes |
RXRβ |
T9960 |
2674-2678 |
DT |
denotes |
this |
T9961 |
2679-2683 |
NN |
denotes |
case |
T9962 |
2683-2685 |
, |
denotes |
, |
T9963 |
2689-2690 |
-RRB- |
denotes |
) |
T9964 |
2691-2692 |
-LRB- |
denotes |
( |
T9965 |
2692-2696 |
NN |
denotes |
Fig. |
T9966 |
2697-2698 |
CD |
denotes |
7 |
T9967 |
2698-2699 |
-RRB- |
denotes |
) |
T9968 |
2700-2701 |
-LRB- |
denotes |
[ |
T9969 |
2703-2705 |
CD |
denotes |
34 |
T9970 |
2701-2702 |
CD |
denotes |
3 |
T9971 |
2702-2703 |
, |
denotes |
, |
T9972 |
2705-2706 |
-RRB- |
denotes |
] |
T9973 |
2706-2707 |
. |
denotes |
. |
T9974 |
2707-2889 |
sentence |
denotes |
However, the tissue specific splicing of the 5 kb exon in the TACC2l isoform [3] indicates that this protein has several temporal and tissue specific functions yet to be identified. |
T9975 |
2708-2715 |
RB |
denotes |
However |
T9976 |
2789-2798 |
VBZ |
denotes |
indicates |
T9977 |
2715-2717 |
, |
denotes |
, |
T9978 |
2717-2720 |
DT |
denotes |
the |
T9979 |
2737-2745 |
NN |
denotes |
splicing |
T9980 |
2721-2727 |
NN |
denotes |
tissue |
T9981 |
2728-2736 |
JJ |
denotes |
specific |
T9982 |
2746-2748 |
IN |
denotes |
of |
T9983 |
2749-2752 |
DT |
denotes |
the |
T9984 |
2758-2762 |
NN |
denotes |
exon |
T9985 |
2753-2754 |
CD |
denotes |
5 |
T9986 |
2755-2757 |
NN |
denotes |
kb |
T9987 |
2763-2765 |
IN |
denotes |
in |
T9988 |
2766-2769 |
DT |
denotes |
the |
T9989 |
2777-2784 |
NN |
denotes |
isoform |
T9990 |
2770-2776 |
NN |
denotes |
TACC2l |
T9991 |
2785-2786 |
-LRB- |
denotes |
[ |
T9992 |
2786-2787 |
CD |
denotes |
3 |
T9993 |
2787-2788 |
-RRB- |
denotes |
] |
T9994 |
2799-2803 |
IN |
denotes |
that |
T9995 |
2817-2820 |
VBZ |
denotes |
has |
T9996 |
2804-2808 |
DT |
denotes |
this |
T9997 |
2809-2816 |
NN |
denotes |
protein |
T9998 |
2821-2828 |
JJ |
denotes |
several |
T9999 |
2858-2867 |
NNS |
denotes |
functions |
T10000 |
2829-2837 |
JJ |
denotes |
temporal |
T10001 |
2838-2841 |
CC |
denotes |
and |
T10002 |
2842-2848 |
NN |
denotes |
tissue |
T10003 |
2849-2857 |
JJ |
denotes |
specific |
T10004 |
2868-2871 |
RB |
denotes |
yet |
T10005 |
2878-2888 |
VBN |
denotes |
identified |
T10006 |
2872-2874 |
TO |
denotes |
to |
T10007 |
2875-2877 |
VB |
denotes |
be |
T10008 |
2888-2889 |
. |
denotes |
. |
R6202 |
T9719 |
T9715 |
prep |
to,response |
R6203 |
T9720 |
T9719 |
pobj |
hypoxia,to |
R6204 |
T9721 |
T9720 |
cc |
and,hypoxia |
R6205 |
T9722 |
T9723 |
amod |
polyaromatic,hydrocarbons |
R6206 |
T9723 |
T9720 |
conj |
hydrocarbons,hypoxia |
R6207 |
T9724 |
T9725 |
punct |
[,7 |
R6208 |
T9725 |
T9694 |
parataxis |
7,was |
R6209 |
T9726 |
T9725 |
punct |
],7 |
R6210 |
T9727 |
T9694 |
punct |
.,was |
R6211 |
T9729 |
T9730 |
compound |
Mouse,TACC3 |
R6212 |
T9730 |
T9731 |
nsubjpass |
TACC3,reported |
R6213 |
T9732 |
T9731 |
aux |
has,reported |
R6214 |
T9733 |
T9731 |
advmod |
also,reported |
R6215 |
T9734 |
T9731 |
auxpass |
been,reported |
R6216 |
T9735 |
T9736 |
aux |
to,interact |
R6217 |
T9736 |
T9731 |
xcomp |
interact,reported |
R6218 |
T9737 |
T9736 |
prep |
with,interact |
R6219 |
T9738 |
T9739 |
det |
the,STAT5 |
R6220 |
T9739 |
T9737 |
pobj |
STAT5,with |
R6221 |
T9740 |
T9739 |
compound |
transcription,STAT5 |
R6222 |
T9741 |
T9739 |
compound |
factor,STAT5 |
R6223 |
T9742 |
T9743 |
punct |
[,33 |
R6224 |
T9743 |
T9731 |
parataxis |
33,reported |
R6225 |
T9744 |
T9743 |
punct |
],33 |
R6226 |
T9745 |
T9731 |
punct |
.,reported |
R6227 |
T9747 |
T9748 |
advmod |
Recently,demonstrated |
R6228 |
T9749 |
T9748 |
punct |
", ",demonstrated |
R6229 |
T9750 |
T9748 |
nsubj |
we,demonstrated |
R6230 |
T9751 |
T9748 |
aux |
have,demonstrated |
R6231 |
T9752 |
T9753 |
mark |
that,bind |
R6232 |
T9753 |
T9748 |
ccomp |
bind,demonstrated |
R6233 |
T9754 |
T9753 |
nsubj |
TACC2,bind |
R6234 |
T9755 |
T9754 |
cc |
and,TACC2 |
R6235 |
T9756 |
T9754 |
conj |
TACC3,TACC2 |
R6236 |
T9757 |
T9753 |
aux |
can,bind |
R6237 |
T9758 |
T9753 |
prep |
to,bind |
R6238 |
T9759 |
T9760 |
amod |
nuclear,acetyltransferases |
R6239 |
T9760 |
T9758 |
pobj |
acetyltransferases,to |
R6240 |
T9761 |
T9760 |
compound |
histone,acetyltransferases |
R6241 |
T9762 |
T9763 |
punct |
[,34 |
R6242 |
T9763 |
T9748 |
parataxis |
34,demonstrated |
R6243 |
T9764 |
T9763 |
punct |
],34 |
R6244 |
T9765 |
T9748 |
punct |
", ",demonstrated |
R6245 |
T9766 |
T9767 |
advmod |
further,confirming |
R6246 |
T9767 |
T9748 |
advcl |
confirming,demonstrated |
R6247 |
T9768 |
T9769 |
det |
a,role |
R6248 |
T9769 |
T9767 |
dobj |
role,confirming |
R6249 |
T9770 |
T9771 |
advmod |
more,direct |
R6250 |
T9771 |
T9769 |
amod |
direct,role |
R6251 |
T9772 |
T9769 |
prep |
for,role |
R6252 |
T9773 |
T9774 |
det |
the,proteins |
R6253 |
T9774 |
T9772 |
pobj |
proteins,for |
R6254 |
T9775 |
T9774 |
compound |
TACC,proteins |
R6255 |
T9776 |
T9769 |
prep |
in,role |
R6256 |
T9777 |
T9778 |
amod |
transcriptional,events |
R6257 |
T9778 |
T9776 |
pobj |
events,in |
R6258 |
T9779 |
T9777 |
cc |
and,transcriptional |
R6259 |
T9780 |
T9781 |
compound |
chromatin,remodeling |
R6260 |
T9781 |
T9777 |
conj |
remodeling,transcriptional |
R6261 |
T9782 |
T9748 |
punct |
.,demonstrated |
R6262 |
T9784 |
T9785 |
advmod |
Interestingly,interact |
R6263 |
T9786 |
T9787 |
mark |
although,interact |
R6264 |
T9787 |
T9785 |
advcl |
interact,interact |
R6265 |
T9788 |
T9789 |
det |
all,proteins |
R6266 |
T9789 |
T9787 |
nsubj |
proteins,interact |
R6267 |
T9790 |
T9789 |
amod |
human,proteins |
R6268 |
T9791 |
T9789 |
compound |
TACC,proteins |
R6269 |
T9792 |
T9787 |
aux |
can,interact |
R6270 |
T9793 |
T9787 |
advmod |
directly,interact |
R6271 |
T9794 |
T9787 |
prep |
with,interact |
R6272 |
T9795 |
T9796 |
det |
the,acetyltransferase |
R6273 |
T9796 |
T9794 |
pobj |
acetyltransferase,with |
R6274 |
T9797 |
T9796 |
compound |
histone,acetyltransferase |
R6275 |
T9798 |
T9796 |
appos |
pCAF,acetyltransferase |
R6276 |
T9799 |
T9800 |
advmod |
in,vitro |
R6277 |
T9800 |
T9787 |
advmod |
vitro,interact |
R6278 |
T9801 |
T9785 |
punct |
", ",interact |
R6279 |
T9802 |
T9803 |
det |
the,isoforms |
R6280 |
T9803 |
T9785 |
nsubj |
isoforms,interact |
R6281 |
T9804 |
T9803 |
compound |
TACC1,isoforms |
R6282 |
T9805 |
T9803 |
acl |
expressed,isoforms |
R6283 |
T9806 |
T9805 |
prep |
in,expressed |
R6284 |
T9807 |
T9808 |
amod |
human,cells |
R6285 |
T9808 |
T9806 |
pobj |
cells,in |
R6286 |
T9809 |
T9810 |
compound |
breast,cancer |
R6287 |
T9810 |
T9808 |
compound |
cancer,cells |
R6288 |
T9811 |
T9785 |
aux |
do,interact |
R6289 |
T9812 |
T9785 |
neg |
not,interact |
R6290 |
T9813 |
T9785 |
prep |
with,interact |
R6291 |
T9814 |
T9815 |
det |
this,acetylase |
R6292 |
T9815 |
T9813 |
pobj |
acetylase,with |
R6293 |
T9816 |
T9815 |
compound |
histone,acetylase |
R6294 |
T9817 |
T9818 |
punct |
[,34 |
R6295 |
T9818 |
T9785 |
parataxis |
34,interact |
R6296 |
T9819 |
T9818 |
punct |
],34 |
R6297 |
T9820 |
T9785 |
punct |
.,interact |
R6298 |
T9822 |
T9823 |
nsubj |
This,be |
R6299 |
T9824 |
T9823 |
aux |
may,be |
R6300 |
T9825 |
T9823 |
acomp |
attributable,be |
R6301 |
T9826 |
T9825 |
prep |
to,attributable |
R6302 |
T9827 |
T9828 |
det |
the,function |
R6303 |
T9828 |
T9826 |
pobj |
function,to |
R6304 |
T9829 |
T9828 |
amod |
proposed,function |
R6305 |
T9830 |
T9828 |
prep |
of,function |
R6306 |
T9831 |
T9832 |
det |
the,variants |
R6307 |
T9832 |
T9830 |
pobj |
variants,of |
R6308 |
T9833 |
T9834 |
npadvmod |
Exon,containing |
R6309 |
T9834 |
T9832 |
amod |
containing,variants |
R6310 |
T9835 |
T9833 |
nummod |
1,Exon |
R6311 |
T9836 |
T9832 |
compound |
TACC1,variants |
R6312 |
T9837 |
T9832 |
prep |
in,variants |
R6313 |
T9838 |
T9839 |
compound |
RNA,processing |
R6314 |
T9839 |
T9837 |
pobj |
processing,in |
R6315 |
T9840 |
T9823 |
punct |
", ",be |
R6316 |
T9841 |
T9823 |
prep |
via,be |
R6317 |
T9842 |
T9843 |
det |
the,interaction |
R6318 |
T9843 |
T9841 |
pobj |
interaction,via |
R6319 |
T9844 |
T9843 |
prep |
with,interaction |
R6320 |
T9845 |
T9844 |
pobj |
LSm,with |
R6321 |
T9846 |
T9845 |
punct |
-,LSm |
R6322 |
T9847 |
T9845 |
nummod |
7,LSm |
R6323 |
T9848 |
T9845 |
cc |
and,LSm |
R6324 |
T9849 |
T9845 |
conj |
SmG,LSm |
R6325 |
T9850 |
T9851 |
punct |
[,19 |
R6326 |
T9851 |
T9823 |
parataxis |
19,be |
R6327 |
T9852 |
T9851 |
punct |
],19 |
R6328 |
T9853 |
T9823 |
punct |
.,be |
R6329 |
T9855 |
T9856 |
advmod |
Thus,adds |
R6330 |
T9857 |
T9856 |
punct |
", ",adds |
R6331 |
T9858 |
T9859 |
amod |
alternative,splicing |
R6332 |
T9859 |
T9856 |
nsubj |
splicing,adds |
R6333 |
T9860 |
T9859 |
prep |
of,splicing |
R6334 |
T9861 |
T9862 |
det |
the,gene |
R6335 |
T9862 |
T9860 |
pobj |
gene,of |
R6336 |
T9863 |
T9862 |
compound |
TACC1,gene |
R6337 |
T9864 |
T9865 |
amod |
further,diversity |
R6338 |
T9865 |
T9856 |
dobj |
diversity,adds |
R6339 |
T9866 |
T9856 |
prep |
to,adds |
R6340 |
T9867 |
T9868 |
compound |
TACC1,function |
R6341 |
T9868 |
T9866 |
pobj |
function,to |
R6342 |
T9869 |
T9856 |
punct |
", ",adds |
R6343 |
T9870 |
T9871 |
mark |
as,change |
R6344 |
T9871 |
T9856 |
advcl |
change,adds |
R6345 |
T9872 |
T9873 |
det |
the,deletion |
R6346 |
T9873 |
T9871 |
nsubj |
deletion,change |
R6347 |
T9874 |
T9873 |
prep |
of,deletion |
R6348 |
T9875 |
T9876 |
amod |
specific,exons |
R6349 |
T9876 |
T9874 |
pobj |
exons,of |
R6350 |
T9877 |
T9876 |
cc |
and,exons |
R6351 |
T9878 |
T9879 |
poss |
their,domains |
R6352 |
T9879 |
T9876 |
conj |
domains,exons |
R6353 |
T9880 |
T9879 |
amod |
associated,domains |
R6354 |
T9881 |
T9879 |
compound |
binding,domains |
R6355 |
T9882 |
T9871 |
aux |
will,change |
R6356 |
T9883 |
T9884 |
det |
the,complexes |
R6357 |
T9884 |
T9871 |
dobj |
complexes,change |
R6358 |
T9885 |
T9884 |
amod |
potential,complexes |
R6359 |
T9886 |
T9884 |
compound |
protein,complexes |
R6360 |
T9887 |
T9888 |
prep |
with,associate |
R6361 |
T9888 |
T9884 |
relcl |
associate,complexes |
R6362 |
T9889 |
T9887 |
pobj |
which,with |
R6363 |
T9890 |
T9888 |
nsubj |
they,associate |
R6364 |
T9891 |
T9888 |
aux |
can,associate |
R6365 |
T9892 |
T9871 |
punct |
", ",change |
R6366 |
T9893 |
T9894 |
preconj |
either,by |
R6367 |
T9894 |
T9871 |
prep |
by,change |
R6368 |
T9895 |
T9894 |
advmod |
directly,by |
R6369 |
T9896 |
T9894 |
punct |
", ",by |
R6370 |
T9897 |
T9894 |
cc |
or,by |
R6371 |
T9898 |
T9894 |
pcomp |
redirecting,by |
R6372 |
T9899 |
T9900 |
det |
the,variants |
R6373 |
T9900 |
T9898 |
dobj |
variants,redirecting |
R6374 |
T9901 |
T9900 |
compound |
splice,variants |
R6375 |
T9902 |
T9898 |
prep |
to,redirecting |
R6376 |
T9903 |
T9904 |
amod |
different,compartments |
R6377 |
T9904 |
T9902 |
pobj |
compartments,to |
R6378 |
T9905 |
T9904 |
amod |
subcellular,compartments |
R6379 |
T9906 |
T9856 |
punct |
.,adds |
R6380 |
T9908 |
T9909 |
prep |
With,is |
R6381 |
T9910 |
T9911 |
det |
the,duplication |
R6382 |
T9911 |
T9908 |
pobj |
duplication,With |
R6383 |
T9912 |
T9911 |
prep |
of,duplication |
R6384 |
T9913 |
T9914 |
det |
the,ancestor |
R6385 |
T9914 |
T9912 |
pobj |
ancestor,of |
R6386 |
T9915 |
T9916 |
compound |
TACC1,TACC2 |
R6387 |
T9916 |
T9914 |
compound |
TACC2,ancestor |
R6388 |
T9917 |
T9916 |
punct |
/,TACC2 |
R6389 |
T9918 |
T9909 |
punct |
", ",is |
R6390 |
T9919 |
T9909 |
nsubj |
it,is |
R6391 |
T9920 |
T9909 |
acomp |
apparent,is |
R6392 |
T9921 |
T9922 |
mark |
that,introduced |
R6393 |
T9922 |
T9909 |
ccomp |
introduced,is |
R6394 |
T9923 |
T9924 |
det |
an,diversity |
R6395 |
T9924 |
T9922 |
nsubjpass |
diversity,introduced |
R6396 |
T9925 |
T9926 |
advmod |
even,greater |
R6397 |
T9926 |
T9924 |
amod |
greater,diversity |
R6398 |
T9927 |
T9924 |
amod |
functional,diversity |
R6399 |
T9928 |
T9922 |
aux |
may,introduced |
R6400 |
T9929 |
T9922 |
aux |
have,introduced |
R6401 |
T9930 |
T9922 |
auxpass |
been,introduced |
R6402 |
T9931 |
T9922 |
prep |
into,introduced |
R6403 |
T9932 |
T9933 |
det |
the,family |
R6404 |
T9933 |
T9931 |
pobj |
family,into |
R6405 |
T9934 |
T9933 |
compound |
TACC,family |
R6406 |
T9935 |
T9909 |
punct |
.,is |
R6407 |
T9937 |
T9938 |
det |
The,protein |
R6408 |
T9938 |
T9940 |
nsubj |
protein,retains |
R6409 |
T9939 |
T9938 |
compound |
TACC2,protein |
R6410 |
T9941 |
T9942 |
det |
the,ability |
R6411 |
T9942 |
T9940 |
dobj |
ability,retains |
R6412 |
T9943 |
T9942 |
prep |
of,ability |
R6413 |
T9944 |
T9943 |
pobj |
TACC3,of |
R6414 |
T9945 |
T9946 |
aux |
to,interact |
R6415 |
T9946 |
T9942 |
acl |
interact,ability |
R6416 |
T9947 |
T9946 |
prep |
with,interact |
R6417 |
T9948 |
T9947 |
pobj |
GAS41,with |
R6418 |
T9949 |
T9948 |
punct |
", ",GAS41 |
R6419 |
T9950 |
T9948 |
conj |
INI1,GAS41 |
R6420 |
T9951 |
T9950 |
punct |
", ",INI1 |
R6421 |
T9952 |
T9953 |
compound |
histone,acetyltransferases |
R6422 |
T9953 |
T9950 |
conj |
acetyltransferases,INI1 |
R6423 |
T9954 |
T9953 |
cc |
and,acetyltransferases |
R6424 |
T9955 |
T9956 |
compound |
transcription,factors |
R6425 |
T9956 |
T9953 |
conj |
factors,acetyltransferases |
R6426 |
T9957 |
T9956 |
punct |
(,factors |
R6427 |
T9958 |
T9959 |
prep |
in,RXRβ |
R6428 |
T9959 |
T9956 |
appos |
RXRβ,factors |
R6429 |
T9960 |
T9961 |
det |
this,case |
R6430 |
T9961 |
T9958 |
pobj |
case,in |
R6431 |
T9962 |
T9959 |
punct |
", ",RXRβ |
R6432 |
T9963 |
T9956 |
punct |
),factors |
R6433 |
T9964 |
T9965 |
punct |
(,Fig. |
R6434 |
T9965 |
T9946 |
parataxis |
Fig.,interact |
R6435 |
T9966 |
T9965 |
nummod |
7,Fig. |
R6436 |
T9967 |
T9965 |
punct |
),Fig. |
R6437 |
T9968 |
T9969 |
punct |
[,34 |
R6438 |
T9969 |
T9946 |
parataxis |
34,interact |
R6439 |
T9970 |
T9969 |
nummod |
3,34 |
R6440 |
T9971 |
T9969 |
punct |
",",34 |
R6441 |
T9972 |
T9969 |
punct |
],34 |
R6442 |
T9973 |
T9940 |
punct |
.,retains |
R6443 |
T9975 |
T9976 |
advmod |
However,indicates |
R6444 |
T9977 |
T9976 |
punct |
", ",indicates |
R6445 |
T9978 |
T9979 |
det |
the,splicing |
R6446 |
T9979 |
T9976 |
nsubj |
splicing,indicates |
R6447 |
T9980 |
T9981 |
npadvmod |
tissue,specific |
R6448 |
T9981 |
T9979 |
amod |
specific,splicing |
R6449 |
T9982 |
T9979 |
prep |
of,splicing |
R6450 |
T9983 |
T9984 |
det |
the,exon |
R6451 |
T9984 |
T9982 |
pobj |
exon,of |
R6452 |
T9985 |
T9986 |
nummod |
5,kb |
R6453 |
T9986 |
T9984 |
compound |
kb,exon |
R6454 |
T9987 |
T9984 |
prep |
in,exon |
R6455 |
T9988 |
T9989 |
det |
the,isoform |
R6456 |
T9989 |
T9987 |
pobj |
isoform,in |
R6457 |
T9990 |
T9989 |
compound |
TACC2l,isoform |
R6458 |
T9991 |
T9992 |
punct |
[,3 |
R6459 |
T9992 |
T9979 |
parataxis |
3,splicing |
R6460 |
T9993 |
T9992 |
punct |
],3 |
R6461 |
T9994 |
T9995 |
mark |
that,has |
R6462 |
T9995 |
T9976 |
ccomp |
has,indicates |
R6463 |
T9996 |
T9997 |
det |
this,protein |
R6464 |
T9997 |
T9995 |
nsubj |
protein,has |
R6465 |
T9998 |
T9999 |
amod |
several,functions |
R6466 |
T9999 |
T9995 |
dobj |
functions,has |
R6467 |
T10000 |
T9999 |
amod |
temporal,functions |
R6468 |
T10001 |
T10000 |
cc |
and,temporal |
R6469 |
T10002 |
T10003 |
npadvmod |
tissue,specific |
R6470 |
T10003 |
T10000 |
conj |
specific,temporal |
R6471 |
T10004 |
T10005 |
advmod |
yet,identified |
R6472 |
T10005 |
T9999 |
advcl |
identified,functions |
R6473 |
T10006 |
T10005 |
aux |
to,identified |
R6474 |
T10007 |
T10005 |
auxpass |
be,identified |
R6475 |
T10008 |
T9976 |
punct |
.,indicates |
R5990 |
T9492 |
T9493 |
amod |
Proposed,evolution |
R5991 |
T9494 |
T9493 |
amod |
functional,evolution |
R5992 |
T9495 |
T9493 |
prep |
of,evolution |
R5993 |
T9496 |
T9497 |
det |
the,family |
R5994 |
T9497 |
T9495 |
pobj |
family,of |
R5995 |
T9498 |
T9497 |
compound |
TACC,family |
R5996 |
T9500 |
T9501 |
nsubj |
Examination,provides |
R5997 |
T9502 |
T9500 |
prep |
of,Examination |
R5998 |
T9503 |
T9504 |
det |
the,evolution |
R5999 |
T9504 |
T9502 |
pobj |
evolution,of |
R6000 |
T9505 |
T9504 |
prep |
of,evolution |
R6001 |
T9506 |
T9507 |
amod |
ancient,families |
R6002 |
T9507 |
T9505 |
pobj |
families,of |
R6003 |
T9508 |
T9507 |
compound |
gene,families |
R6004 |
T9509 |
T9510 |
det |
an,insight |
R6005 |
T9510 |
T9501 |
dobj |
insight,provides |
R6006 |
T9511 |
T9501 |
prep |
into,provides |
R6007 |
T9512 |
T9513 |
advmod |
how,relates |
R6008 |
T9513 |
T9511 |
pcomp |
relates,into |
R6009 |
T9514 |
T9515 |
compound |
gene,structure |
R6010 |
T9515 |
T9513 |
nsubj |
structure,relates |
R6011 |
T9516 |
T9513 |
prep |
to,relates |
R6012 |
T9517 |
T9516 |
pobj |
function,to |
R6013 |
T9518 |
T9501 |
punct |
.,provides |
R6014 |
T9520 |
T9521 |
nsubj |
We,presented |
R6015 |
T9522 |
T9521 |
aux |
have,presented |
R6016 |
T9523 |
T9521 |
advmod |
above,presented |
R6017 |
T9524 |
T9521 |
punct |
", ",presented |
R6018 |
T9525 |
T9526 |
det |
a,examination |
R6019 |
T9526 |
T9521 |
dobj |
examination,presented |
R6020 |
T9527 |
T9526 |
amod |
detailed,examination |
R6021 |
T9528 |
T9526 |
prep |
of,examination |
R6022 |
T9529 |
T9530 |
nummod |
one,family |
R6023 |
T9530 |
T9528 |
pobj |
family,of |
R6024 |
T9531 |
T9530 |
amod |
such,family |
R6025 |
T9532 |
T9530 |
compound |
gene,family |
R6026 |
T9533 |
T9521 |
punct |
.,presented |
R6027 |
T9535 |
T9536 |
det |
The,data |
R6028 |
T9536 |
T9537 |
nsubj |
data,suggest |
R6029 |
T9538 |
T9539 |
advmod |
so,far |
R6030 |
T9539 |
T9537 |
advmod |
far,suggest |
R6031 |
T9540 |
T9541 |
mark |
that,has |
R6032 |
T9541 |
T9537 |
ccomp |
has,suggest |
R6033 |
T9542 |
T9543 |
det |
the,homologue |
R6034 |
T9543 |
T9541 |
nsubj |
homologue,has |
R6035 |
T9544 |
T9543 |
amod |
functional,homologue |
R6036 |
T9545 |
T9543 |
compound |
TACC,homologue |
R6037 |
T9546 |
T9543 |
prep |
in,homologue |
R6038 |
T9547 |
T9546 |
pobj |
yeast,in |
R6039 |
T9548 |
T9543 |
punct |
(,homologue |
R6040 |
T9549 |
T9543 |
appos |
spc72,homologue |
R6041 |
T9550 |
T9543 |
punct |
),homologue |
R6042 |
T9551 |
T9552 |
det |
a,role |
R6043 |
T9552 |
T9541 |
dobj |
role,has |
R6044 |
T9553 |
T9552 |
amod |
specific,role |
R6045 |
T9554 |
T9552 |
prep |
in,role |
R6046 |
T9555 |
T9556 |
amod |
centrosomal,mitotic |
R6047 |
T9556 |
T9558 |
amod |
mitotic,spindle |
R6048 |
T9557 |
T9556 |
punct |
/,mitotic |
R6049 |
T9558 |
T9559 |
compound |
spindle,dynamics |
R6050 |
T9559 |
T9554 |
pobj |
dynamics,in |
R6051 |
T9560 |
T9561 |
punct |
[,22 |
R6052 |
T9561 |
T9537 |
parataxis |
22,suggest |
R6053 |
T9562 |
T9561 |
nummod |
21,22 |
R6054 |
T9563 |
T9561 |
punct |
",",22 |
R6055 |
T9564 |
T9561 |
punct |
],22 |
R6056 |
T9565 |
T9537 |
punct |
.,suggest |
R6057 |
T9567 |
T9568 |
det |
This,function |
R6058 |
T9568 |
T9571 |
nsubjpass |
function,conserved |
R6059 |
T9569 |
T9568 |
amod |
ancient,function |
R6060 |
T9570 |
T9568 |
compound |
TACC,function |
R6061 |
T9572 |
T9571 |
auxpass |
is,conserved |
R6062 |
T9573 |
T9571 |
prep |
throughout,conserved |
R6063 |
T9574 |
T9573 |
pobj |
evolution,throughout |
R6064 |
T9575 |
T9571 |
prep |
in,conserved |
R6065 |
T9576 |
T9577 |
preconj |
both,protostomes |
R6066 |
T9577 |
T9575 |
pobj |
protostomes,in |
R6067 |
T9578 |
T9577 |
cc |
and,protostomes |
R6068 |
T9579 |
T9577 |
conj |
deuterostomes,protostomes |
R6069 |
T9580 |
T9571 |
punct |
.,conserved |
R6070 |
T9582 |
T9583 |
prep |
In,appear |
R6071 |
T9584 |
T9582 |
pobj |
addition,In |
R6072 |
T9585 |
T9583 |
punct |
", ",appear |
R6073 |
T9586 |
T9587 |
det |
the,proteins |
R6074 |
T9587 |
T9583 |
nsubj |
proteins,appear |
R6075 |
T9588 |
T9587 |
compound |
TACC,proteins |
R6076 |
T9589 |
T9587 |
prep |
of,proteins |
R6077 |
T9590 |
T9591 |
amod |
lower,organisms |
R6078 |
T9591 |
T9589 |
pobj |
organisms,of |
R6079 |
T9592 |
T9593 |
aux |
to,interact |
R6080 |
T9593 |
T9583 |
xcomp |
interact,appear |
R6081 |
T9594 |
T9593 |
prep |
with,interact |
R6082 |
T9595 |
T9596 |
compound |
bridging,proteins |
R6083 |
T9596 |
T9594 |
pobj |
proteins,with |
R6084 |
T9597 |
T9598 |
dep |
that,are |
R6085 |
T9598 |
T9596 |
relcl |
are,proteins |
R6086 |
T9599 |
T9598 |
attr |
components,are |
R6087 |
T9600 |
T9599 |
prep |
of,components |
R6088 |
T9601 |
T9602 |
amod |
several,complexes |
R6089 |
T9602 |
T9600 |
pobj |
complexes,of |
R6090 |
T9603 |
T9602 |
amod |
different,complexes |
R6091 |
T9604 |
T9602 |
compound |
protein,complexes |
R6092 |
T9605 |
T9602 |
acl |
involved,complexes |
R6093 |
T9606 |
T9605 |
prep |
in,involved |
R6094 |
T9607 |
T9608 |
compound |
DNA,damage |
R6095 |
T9608 |
T9609 |
compound |
damage,repair |
R6096 |
T9609 |
T9606 |
pobj |
repair,in |
R6097 |
T9610 |
T9609 |
punct |
", ",repair |
R6098 |
T9611 |
T9612 |
compound |
protein,translation |
R6099 |
T9612 |
T9609 |
appos |
translation,repair |
R6100 |
T9613 |
T9609 |
punct |
", ",repair |
R6101 |
T9614 |
T9615 |
compound |
RNA,processing |
R6102 |
T9615 |
T9609 |
appos |
processing,repair |
R6103 |
T9616 |
T9615 |
cc |
and,processing |
R6104 |
T9617 |
T9615 |
conj |
transcription,processing |
R6105 |
T9618 |
T9583 |
punct |
.,appear |
R6106 |
T9620 |
T9621 |
advmod |
However,acquired |
R6107 |
T9622 |
T9621 |
punct |
", ",acquired |
R6108 |
T9623 |
T9621 |
prep |
over,acquired |
R6109 |
T9624 |
T9625 |
det |
the,process |
R6110 |
T9625 |
T9623 |
pobj |
process,over |
R6111 |
T9626 |
T9625 |
prep |
of,process |
R6112 |
T9627 |
T9628 |
amod |
evolutionary,time |
R6113 |
T9628 |
T9626 |
pobj |
time,of |
R6114 |
T9629 |
T9621 |
punct |
", ",acquired |
R6115 |
T9630 |
T9621 |
prep |
with,acquired |
R6116 |
T9631 |
T9632 |
det |
the,acquisition |
R6117 |
T9632 |
T9630 |
pobj |
acquisition,with |
R6118 |
T9633 |
T9632 |
prep |
of,acquisition |
R6119 |
T9634 |
T9635 |
amod |
new,domains |
R6120 |
T9635 |
T9633 |
pobj |
domains,of |
R6121 |
T9636 |
T9635 |
cc |
and,domains |
R6122 |
T9637 |
T9635 |
conj |
duplication,domains |
R6123 |
T9638 |
T9637 |
prep |
of,duplication |
R6124 |
T9639 |
T9640 |
det |
the,precursor |
R6125 |
T9640 |
T9638 |
pobj |
precursor,of |
R6126 |
T9641 |
T9640 |
compound |
chordate,precursor |
R6127 |
T9642 |
T9640 |
compound |
TACC,precursor |
R6128 |
T9643 |
T9621 |
punct |
", ",acquired |
R6129 |
T9644 |
T9645 |
det |
the,proteins |
R6130 |
T9645 |
T9621 |
nsubj |
proteins,acquired |
R6131 |
T9646 |
T9645 |
compound |
chordate,proteins |
R6132 |
T9647 |
T9645 |
compound |
TACC,proteins |
R6133 |
T9648 |
T9621 |
aux |
have,acquired |
R6134 |
T9649 |
T9650 |
det |
the,ability |
R6135 |
T9650 |
T9621 |
dobj |
ability,acquired |
R6136 |
T9651 |
T9652 |
aux |
to,interact |
R6137 |
T9652 |
T9650 |
acl |
interact,ability |
R6138 |
T9653 |
T9652 |
advmod |
directly,interact |
R6139 |
T9654 |
T9652 |
prep |
with,interact |
R6140 |
T9655 |
T9654 |
pobj |
some,with |
R6141 |
T9656 |
T9655 |
prep |
of,some |
R6142 |
T9657 |
T9658 |
det |
the,components |
R6143 |
T9658 |
T9656 |
pobj |
components,of |
R6144 |
T9659 |
T9658 |
amod |
other,components |
R6145 |
T9660 |
T9658 |
prep |
of,components |
R6146 |
T9661 |
T9662 |
det |
these,complexes |
R6147 |
T9662 |
T9660 |
pobj |
complexes,of |
R6148 |
T9663 |
T9655 |
punct |
(,some |
R6149 |
T9664 |
T9665 |
amod |
such,as |
R6150 |
T9665 |
T9655 |
prep |
as,some |
R6151 |
T9666 |
T9667 |
det |
the,proteins |
R6152 |
T9667 |
T9665 |
pobj |
proteins,as |
R6153 |
T9668 |
T9667 |
compound |
LSm,proteins |
R6154 |
T9669 |
T9667 |
punct |
", ",proteins |
R6155 |
T9670 |
T9671 |
amod |
nuclear,receptors |
R6156 |
T9671 |
T9667 |
conj |
receptors,proteins |
R6157 |
T9672 |
T9671 |
compound |
hormone,receptors |
R6158 |
T9673 |
T9671 |
punct |
", ",receptors |
R6159 |
T9674 |
T9671 |
conj |
GAS41,receptors |
R6160 |
T9675 |
T9674 |
punct |
", ",GAS41 |
R6161 |
T9676 |
T9677 |
amod |
accessory,proteins |
R6162 |
T9677 |
T9674 |
conj |
proteins,GAS41 |
R6163 |
T9678 |
T9677 |
cc |
and,proteins |
R6164 |
T9679 |
T9680 |
compound |
transcription,factors |
R6165 |
T9680 |
T9677 |
conj |
factors,proteins |
R6166 |
T9681 |
T9655 |
punct |
),some |
R6167 |
T9682 |
T9621 |
punct |
", ",acquired |
R6168 |
T9683 |
T9621 |
cc |
and,acquired |
R6169 |
T9684 |
T9685 |
advmod |
thus,evolved |
R6170 |
T9685 |
T9621 |
conj |
evolved,acquired |
R6171 |
T9686 |
T9687 |
amod |
additional,functions |
R6172 |
T9687 |
T9685 |
dobj |
functions,evolved |
R6173 |
T9688 |
T9685 |
prep |
within,evolved |
R6174 |
T9689 |
T9690 |
det |
these,complexes |
R6175 |
T9690 |
T9688 |
pobj |
complexes,within |
R6176 |
T9691 |
T9621 |
punct |
.,acquired |
R6177 |
T9693 |
T9694 |
advmod |
Indeed,was |
R6178 |
T9695 |
T9694 |
punct |
", ",was |
R6179 |
T9696 |
T9697 |
det |
the,function |
R6180 |
T9697 |
T9694 |
nsubj |
function,was |
R6181 |
T9698 |
T9697 |
amod |
first,function |
R6182 |
T9699 |
T9697 |
amod |
assigned,function |
R6183 |
T9700 |
T9697 |
prep |
of,function |
R6184 |
T9701 |
T9702 |
det |
a,protein |
R6185 |
T9702 |
T9700 |
pobj |
protein,of |
R6186 |
T9703 |
T9702 |
compound |
vertebrate,protein |
R6187 |
T9704 |
T9702 |
compound |
TACC,protein |
R6188 |
T9705 |
T9702 |
punct |
", ",protein |
R6189 |
T9706 |
T9707 |
compound |
mouse,TACC3 |
R6190 |
T9707 |
T9702 |
appos |
TACC3,protein |
R6191 |
T9708 |
T9694 |
punct |
", ",was |
R6192 |
T9709 |
T9694 |
prep |
as,was |
R6193 |
T9710 |
T9711 |
det |
a,coactivator |
R6194 |
T9711 |
T9709 |
pobj |
coactivator,as |
R6195 |
T9712 |
T9711 |
amod |
transcriptional,coactivator |
R6196 |
T9713 |
T9711 |
prep |
of,coactivator |
R6197 |
T9714 |
T9715 |
det |
the,response |
R6198 |
T9715 |
T9713 |
pobj |
response,of |
R6199 |
T9716 |
T9717 |
npadvmod |
ARNT,mediated |
R6200 |
T9717 |
T9715 |
amod |
mediated,response |
R6201 |
T9718 |
T9715 |
amod |
transcriptional,response |