Id |
Subject |
Object |
Predicate |
Lexical cue |
T8740 |
0-2 |
TO |
denotes |
To |
T8741 |
11-23 |
VB |
denotes |
characterize |
T8742 |
3-10 |
RB |
denotes |
further |
T8743 |
77-81 |
VBN |
denotes |
used |
T8744 |
24-27 |
DT |
denotes |
the |
T8745 |
37-46 |
NNS |
denotes |
functions |
T8746 |
28-36 |
VBG |
denotes |
evolving |
T8747 |
47-49 |
IN |
denotes |
of |
T8748 |
50-53 |
DT |
denotes |
the |
T8749 |
59-67 |
NN |
denotes |
proteins |
T8750 |
54-58 |
NN |
denotes |
TACC |
T8751 |
67-69 |
, |
denotes |
, |
T8752 |
69-71 |
PRP |
denotes |
we |
T8753 |
72-76 |
VBP |
denotes |
have |
T8754 |
82-84 |
DT |
denotes |
an |
T8755 |
121-127 |
NN |
denotes |
method |
T8756 |
85-93 |
JJ |
denotes |
unbiased |
T8757 |
94-99 |
NN |
denotes |
yeast |
T8758 |
100-103 |
CD |
denotes |
two |
T8759 |
104-110 |
NN |
denotes |
hybrid |
T8760 |
111-120 |
NN |
denotes |
screening |
T8761 |
128-130 |
TO |
denotes |
to |
T8762 |
131-139 |
VB |
denotes |
identify |
T8763 |
140-148 |
NN |
denotes |
proteins |
T8764 |
149-153 |
WDT |
denotes |
that |
T8765 |
154-158 |
VBP |
denotes |
bind |
T8766 |
159-161 |
IN |
denotes |
to |
T8767 |
162-165 |
DT |
denotes |
the |
T8768 |
177-185 |
NN |
denotes |
proteins |
T8769 |
166-171 |
JJ |
denotes |
human |
T8770 |
172-176 |
NN |
denotes |
TACC |
T8771 |
186-187 |
-LRB- |
denotes |
[ |
T8772 |
189-191 |
CD |
denotes |
34 |
T8773 |
187-188 |
CD |
denotes |
3 |
T8774 |
188-189 |
, |
denotes |
, |
T8775 |
191-192 |
-RRB- |
denotes |
] |
T8776 |
192-193 |
. |
denotes |
. |
T8777 |
193-455 |
sentence |
denotes |
In a screen of a MATCHMAKER fetal brain library (BD Biosciences Clontech), in addition to isolating the histone acetyltransferase hGCN5L2 [34], we also identified the β3 isoform of retinoid-X receptor β as a protein that interacts with the TACC domain of TACC2. |
T8778 |
194-196 |
IN |
denotes |
In |
T8779 |
346-356 |
VBD |
denotes |
identified |
T8780 |
197-198 |
DT |
denotes |
a |
T8781 |
199-205 |
NN |
denotes |
screen |
T8782 |
206-208 |
IN |
denotes |
of |
T8783 |
209-210 |
DT |
denotes |
a |
T8784 |
234-241 |
NN |
denotes |
library |
T8785 |
211-221 |
NN |
denotes |
MATCHMAKER |
T8786 |
222-227 |
JJ |
denotes |
fetal |
T8787 |
228-233 |
NN |
denotes |
brain |
T8788 |
242-243 |
-LRB- |
denotes |
( |
T8789 |
258-266 |
NNP |
denotes |
Clontech |
T8790 |
243-245 |
NNP |
denotes |
BD |
T8791 |
246-257 |
NNPS |
denotes |
Biosciences |
T8792 |
266-267 |
-RRB- |
denotes |
) |
T8793 |
267-269 |
, |
denotes |
, |
T8794 |
269-271 |
IN |
denotes |
in |
T8795 |
272-280 |
NN |
denotes |
addition |
T8796 |
281-283 |
IN |
denotes |
to |
T8797 |
284-293 |
VBG |
denotes |
isolating |
T8798 |
294-297 |
DT |
denotes |
the |
T8799 |
306-323 |
NN |
denotes |
acetyltransferase |
T8800 |
298-305 |
NN |
denotes |
histone |
T8801 |
324-331 |
NN |
denotes |
hGCN5L2 |
T8802 |
332-333 |
-LRB- |
denotes |
[ |
T8803 |
333-335 |
CD |
denotes |
34 |
T8804 |
335-336 |
-RRB- |
denotes |
] |
T8805 |
336-338 |
, |
denotes |
, |
T8806 |
338-340 |
PRP |
denotes |
we |
T8807 |
341-345 |
RB |
denotes |
also |
T8808 |
357-360 |
DT |
denotes |
the |
T8809 |
364-371 |
NN |
denotes |
isoform |
T8810 |
361-363 |
NN |
denotes |
β3 |
T8811 |
372-374 |
IN |
denotes |
of |
T8812 |
375-383 |
NN |
denotes |
retinoid |
T8813 |
384-385 |
NN |
denotes |
X |
T8814 |
383-384 |
HYPH |
denotes |
- |
T8815 |
395-396 |
NN |
denotes |
β |
T8816 |
386-394 |
NN |
denotes |
receptor |
T8817 |
397-399 |
IN |
denotes |
as |
T8818 |
400-401 |
DT |
denotes |
a |
T8819 |
402-409 |
NN |
denotes |
protein |
T8820 |
410-414 |
WDT |
denotes |
that |
T8821 |
415-424 |
VBZ |
denotes |
interacts |
T8822 |
425-429 |
IN |
denotes |
with |
T8823 |
430-433 |
DT |
denotes |
the |
T8824 |
439-445 |
NN |
denotes |
domain |
T8825 |
434-438 |
NN |
denotes |
TACC |
T8826 |
446-448 |
IN |
denotes |
of |
T8827 |
449-454 |
NN |
denotes |
TACC2 |
T8828 |
454-455 |
. |
denotes |
. |
T8829 |
455-541 |
sentence |
denotes |
As shown in Fig. 7, this interaction is confirmed in vitro by GST-pull down analysis. |
T8830 |
456-458 |
IN |
denotes |
As |
T8831 |
459-464 |
VBN |
denotes |
shown |
T8832 |
496-505 |
VBN |
denotes |
confirmed |
T8833 |
465-467 |
IN |
denotes |
in |
T8834 |
468-472 |
NN |
denotes |
Fig. |
T8835 |
473-474 |
CD |
denotes |
7 |
T8836 |
474-476 |
, |
denotes |
, |
T8837 |
476-480 |
DT |
denotes |
this |
T8838 |
481-492 |
NN |
denotes |
interaction |
T8839 |
493-495 |
VBZ |
denotes |
is |
T8840 |
506-508 |
FW |
denotes |
in |
T8841 |
509-514 |
FW |
denotes |
vitro |
T8842 |
515-517 |
IN |
denotes |
by |
T8843 |
518-521 |
NN |
denotes |
GST |
T8844 |
522-526 |
VB |
denotes |
pull |
T8845 |
521-522 |
HYPH |
denotes |
- |
T8846 |
532-540 |
NN |
denotes |
analysis |
T8847 |
527-531 |
RP |
denotes |
down |
T8848 |
540-541 |
. |
denotes |
. |
T8849 |
541-710 |
sentence |
denotes |
Significantly, RXRβ is a close family relative of the nuclear hormone receptor, nhr-86, from C. elegans, which interacts with the ceTAC binding protein lin36 (Fig. 6A). |
T8850 |
542-555 |
RB |
denotes |
Significantly |
T8851 |
562-564 |
VBZ |
denotes |
is |
T8852 |
555-557 |
, |
denotes |
, |
T8853 |
557-561 |
NN |
denotes |
RXRβ |
T8854 |
565-566 |
DT |
denotes |
a |
T8855 |
573-579 |
NN |
denotes |
family |
T8856 |
567-572 |
JJ |
denotes |
close |
T8857 |
580-588 |
JJ |
denotes |
relative |
T8858 |
589-591 |
IN |
denotes |
of |
T8859 |
592-595 |
DT |
denotes |
the |
T8860 |
612-620 |
NN |
denotes |
receptor |
T8861 |
596-603 |
JJ |
denotes |
nuclear |
T8862 |
604-611 |
NN |
denotes |
hormone |
T8863 |
620-622 |
, |
denotes |
, |
T8864 |
622-625 |
NN |
denotes |
nhr |
T8865 |
625-626 |
HYPH |
denotes |
- |
T8866 |
626-628 |
CD |
denotes |
86 |
T8867 |
628-630 |
, |
denotes |
, |
T8868 |
630-634 |
IN |
denotes |
from |
T8869 |
635-637 |
NNP |
denotes |
C. |
T8870 |
638-645 |
NNP |
denotes |
elegans |
T8871 |
645-647 |
, |
denotes |
, |
T8872 |
647-652 |
WDT |
denotes |
which |
T8873 |
653-662 |
VBZ |
denotes |
interacts |
T8874 |
663-667 |
IN |
denotes |
with |
T8875 |
668-671 |
DT |
denotes |
the |
T8876 |
686-693 |
NN |
denotes |
protein |
T8877 |
672-677 |
NN |
denotes |
ceTAC |
T8878 |
678-685 |
NN |
denotes |
binding |
T8879 |
694-699 |
NN |
denotes |
lin36 |
T8880 |
700-701 |
-LRB- |
denotes |
( |
T8881 |
701-705 |
NN |
denotes |
Fig. |
T8882 |
706-708 |
CD |
denotes |
6A |
T8883 |
708-709 |
-RRB- |
denotes |
) |
T8884 |
709-710 |
. |
denotes |
. |
T8885 |
710-975 |
sentence |
denotes |
This suggests that while protostome TACCs may require additional protein factors to interact with such components, the TACCs in higher organisms may have evolved the ability to directly interact with some of the proteins in the predicted interaction map (Fig. 6E). |
T8886 |
711-715 |
DT |
denotes |
This |
T8887 |
716-724 |
VBZ |
denotes |
suggests |
T8888 |
725-729 |
IN |
denotes |
that |
T8889 |
865-872 |
VBN |
denotes |
evolved |
T8890 |
730-735 |
IN |
denotes |
while |
T8891 |
757-764 |
VB |
denotes |
require |
T8892 |
736-746 |
NN |
denotes |
protostome |
T8893 |
747-752 |
NNS |
denotes |
TACCs |
T8894 |
753-756 |
MD |
denotes |
may |
T8895 |
765-775 |
JJ |
denotes |
additional |
T8896 |
784-791 |
NNS |
denotes |
factors |
T8897 |
776-783 |
NN |
denotes |
protein |
T8898 |
792-794 |
TO |
denotes |
to |
T8899 |
795-803 |
VB |
denotes |
interact |
T8900 |
804-808 |
IN |
denotes |
with |
T8901 |
809-813 |
JJ |
denotes |
such |
T8902 |
814-824 |
NNS |
denotes |
components |
T8903 |
824-826 |
, |
denotes |
, |
T8904 |
826-829 |
DT |
denotes |
the |
T8905 |
830-835 |
NNS |
denotes |
TACCs |
T8906 |
836-838 |
IN |
denotes |
in |
T8907 |
839-845 |
JJR |
denotes |
higher |
T8908 |
846-855 |
NNS |
denotes |
organisms |
T8909 |
856-859 |
MD |
denotes |
may |
T8910 |
860-864 |
VB |
denotes |
have |
T8911 |
873-876 |
DT |
denotes |
the |
T8912 |
877-884 |
NN |
denotes |
ability |
T8913 |
885-887 |
TO |
denotes |
to |
T8914 |
897-905 |
VB |
denotes |
interact |
T8915 |
888-896 |
RB |
denotes |
directly |
T8916 |
906-910 |
IN |
denotes |
with |
T8917 |
911-915 |
DT |
denotes |
some |
T8918 |
916-918 |
IN |
denotes |
of |
T8919 |
919-922 |
DT |
denotes |
the |
T8920 |
923-931 |
NN |
denotes |
proteins |
T8921 |
932-934 |
IN |
denotes |
in |
T8922 |
935-938 |
DT |
denotes |
the |
T8923 |
961-964 |
NN |
denotes |
map |
T8924 |
939-948 |
VBN |
denotes |
predicted |
T8925 |
949-960 |
NN |
denotes |
interaction |
T8926 |
965-966 |
-LRB- |
denotes |
( |
T8927 |
966-970 |
NN |
denotes |
Fig. |
T8928 |
971-973 |
CD |
denotes |
6E |
T8929 |
973-974 |
-RRB- |
denotes |
) |
T8930 |
974-975 |
. |
denotes |
. |
T8931 |
975-1100 |
sentence |
denotes |
Indeed, this appears to be directly linked to the acquisition of new domains and duplication of the chordate TACC precursor. |
T8932 |
976-982 |
RB |
denotes |
Indeed |
T8933 |
989-996 |
VBZ |
denotes |
appears |
T8934 |
982-984 |
, |
denotes |
, |
T8935 |
984-988 |
DT |
denotes |
this |
T8936 |
997-999 |
TO |
denotes |
to |
T8937 |
1012-1018 |
VBN |
denotes |
linked |
T8938 |
1000-1002 |
VB |
denotes |
be |
T8939 |
1003-1011 |
RB |
denotes |
directly |
T8940 |
1019-1021 |
IN |
denotes |
to |
T8941 |
1022-1025 |
DT |
denotes |
the |
T8942 |
1026-1037 |
NN |
denotes |
acquisition |
T8943 |
1038-1040 |
IN |
denotes |
of |
T8944 |
1041-1044 |
JJ |
denotes |
new |
T8945 |
1045-1052 |
NNS |
denotes |
domains |
T8946 |
1053-1056 |
CC |
denotes |
and |
T8947 |
1057-1068 |
NN |
denotes |
duplication |
T8948 |
1069-1071 |
IN |
denotes |
of |
T8949 |
1072-1075 |
DT |
denotes |
the |
T8950 |
1090-1099 |
NN |
denotes |
precursor |
T8951 |
1076-1084 |
NN |
denotes |
chordate |
T8952 |
1085-1089 |
NN |
denotes |
TACC |
T8953 |
1099-1100 |
. |
denotes |
. |
T8954 |
1100-1281 |
sentence |
denotes |
In fact, the first identified function of a vertebrate TACC protein was as a transcriptional coactivator acting through a direct interaction with the ARNT transcription factor [7]. |
T8955 |
1101-1103 |
IN |
denotes |
In |
T8956 |
1169-1172 |
VBD |
denotes |
was |
T8957 |
1104-1108 |
NN |
denotes |
fact |
T8958 |
1108-1110 |
, |
denotes |
, |
T8959 |
1110-1113 |
DT |
denotes |
the |
T8960 |
1131-1139 |
NN |
denotes |
function |
T8961 |
1114-1119 |
JJ |
denotes |
first |
T8962 |
1120-1130 |
VBN |
denotes |
identified |
T8963 |
1140-1142 |
IN |
denotes |
of |
T8964 |
1143-1144 |
DT |
denotes |
a |
T8965 |
1161-1168 |
NN |
denotes |
protein |
T8966 |
1145-1155 |
NN |
denotes |
vertebrate |
T8967 |
1156-1160 |
NN |
denotes |
TACC |
T8968 |
1173-1175 |
IN |
denotes |
as |
T8969 |
1176-1177 |
DT |
denotes |
a |
T8970 |
1194-1205 |
NN |
denotes |
coactivator |
T8971 |
1178-1193 |
JJ |
denotes |
transcriptional |
T8972 |
1206-1212 |
VBG |
denotes |
acting |
T8973 |
1213-1220 |
IN |
denotes |
through |
T8974 |
1221-1222 |
DT |
denotes |
a |
T8975 |
1230-1241 |
NN |
denotes |
interaction |
T8976 |
1223-1229 |
JJ |
denotes |
direct |
T8977 |
1242-1246 |
IN |
denotes |
with |
T8978 |
1247-1250 |
DT |
denotes |
the |
T8979 |
1270-1276 |
NN |
denotes |
factor |
T8980 |
1251-1255 |
NN |
denotes |
ARNT |
T8981 |
1256-1269 |
NN |
denotes |
transcription |
T8982 |
1277-1278 |
-LRB- |
denotes |
[ |
T8983 |
1278-1279 |
CD |
denotes |
7 |
T8984 |
1279-1280 |
-RRB- |
denotes |
] |
T8985 |
1280-1281 |
. |
denotes |
. |
T8986 |
1281-1454 |
sentence |
denotes |
It is also intriguing that the deuterostome specific SDP repeat interacts with GAS41, a component/accessory factor of the human SWI/SNF chromatin remodeling complex [3,15]. |
T8987 |
1282-1284 |
PRP |
denotes |
It |
T8988 |
1285-1287 |
VBZ |
denotes |
is |
T8989 |
1288-1292 |
RB |
denotes |
also |
T8990 |
1293-1303 |
JJ |
denotes |
intriguing |
T8991 |
1304-1308 |
IN |
denotes |
that |
T8992 |
1346-1355 |
VBZ |
denotes |
interacts |
T8993 |
1309-1312 |
DT |
denotes |
the |
T8994 |
1339-1345 |
NN |
denotes |
repeat |
T8995 |
1313-1325 |
NN |
denotes |
deuterostome |
T8996 |
1326-1334 |
JJ |
denotes |
specific |
T8997 |
1335-1338 |
NN |
denotes |
SDP |
T8998 |
1356-1360 |
IN |
denotes |
with |
T8999 |
1361-1366 |
NN |
denotes |
GAS41 |
T9000 |
1366-1368 |
, |
denotes |
, |
T9001 |
1368-1369 |
DT |
denotes |
a |
T9002 |
1390-1396 |
NN |
denotes |
factor |
T9003 |
1370-1379 |
NN |
denotes |
component |
T9004 |
1380-1389 |
NN |
denotes |
accessory |
T9005 |
1379-1380 |
HYPH |
denotes |
/ |
T9006 |
1397-1399 |
IN |
denotes |
of |
T9007 |
1400-1403 |
DT |
denotes |
the |
T9008 |
1439-1446 |
NN |
denotes |
complex |
T9009 |
1404-1409 |
JJ |
denotes |
human |
T9010 |
1410-1413 |
NN |
denotes |
SWI |
T9011 |
1414-1417 |
NN |
denotes |
SNF |
T9012 |
1413-1414 |
HYPH |
denotes |
/ |
T9013 |
1418-1427 |
NN |
denotes |
chromatin |
T9014 |
1428-1438 |
NN |
denotes |
remodeling |
T9015 |
1447-1448 |
-LRB- |
denotes |
[ |
T9016 |
1450-1452 |
CD |
denotes |
15 |
T9017 |
1448-1449 |
CD |
denotes |
3 |
T9018 |
1449-1450 |
, |
denotes |
, |
T9019 |
1452-1453 |
-RRB- |
denotes |
] |
T9020 |
1453-1454 |
. |
denotes |
. |
T9021 |
1454-1628 |
sentence |
denotes |
Although there is a D. melanogaster homologue of GAS41, dmGAS41, the large scale proteomic interaction database does not indicate a direct interaction of dmGAS41 with DTACC. |
T9022 |
1455-1463 |
IN |
denotes |
Although |
T9023 |
1470-1472 |
VBZ |
denotes |
is |
T9024 |
1464-1469 |
EX |
denotes |
there |
T9025 |
1576-1584 |
VB |
denotes |
indicate |
T9026 |
1473-1474 |
DT |
denotes |
a |
T9027 |
1491-1500 |
NN |
denotes |
homologue |
T9028 |
1475-1477 |
NNP |
denotes |
D. |
T9029 |
1478-1490 |
NNP |
denotes |
melanogaster |
T9030 |
1501-1503 |
IN |
denotes |
of |
T9031 |
1504-1509 |
NN |
denotes |
GAS41 |
T9032 |
1509-1511 |
, |
denotes |
, |
T9033 |
1511-1518 |
NN |
denotes |
dmGAS41 |
T9034 |
1518-1520 |
, |
denotes |
, |
T9035 |
1520-1523 |
DT |
denotes |
the |
T9036 |
1558-1566 |
NN |
denotes |
database |
T9037 |
1524-1529 |
JJ |
denotes |
large |
T9038 |
1530-1535 |
NN |
denotes |
scale |
T9039 |
1546-1557 |
NN |
denotes |
interaction |
T9040 |
1536-1545 |
JJ |
denotes |
proteomic |
T9041 |
1567-1571 |
VBZ |
denotes |
does |
T9042 |
1572-1575 |
RB |
denotes |
not |
T9043 |
1585-1586 |
DT |
denotes |
a |
T9044 |
1594-1605 |
NN |
denotes |
interaction |
T9045 |
1587-1593 |
JJ |
denotes |
direct |
T9046 |
1606-1608 |
IN |
denotes |
of |
T9047 |
1609-1616 |
NN |
denotes |
dmGAS41 |
T9048 |
1617-1621 |
IN |
denotes |
with |
T9049 |
1622-1627 |
NN |
denotes |
DTACC |
T9050 |
1627-1628 |
. |
denotes |
. |
T9051 |
1628-1713 |
sentence |
denotes |
This may be due to the lack of the SDP repeat region in the Drosophila TACC protein. |
T9052 |
1629-1633 |
DT |
denotes |
This |
T9053 |
1638-1640 |
VB |
denotes |
be |
T9054 |
1634-1637 |
MD |
denotes |
may |
T9055 |
1641-1644 |
IN |
denotes |
due |
T9056 |
1645-1647 |
IN |
denotes |
to |
T9057 |
1648-1651 |
DT |
denotes |
the |
T9058 |
1652-1656 |
NN |
denotes |
lack |
T9059 |
1657-1659 |
IN |
denotes |
of |
T9060 |
1660-1663 |
DT |
denotes |
the |
T9061 |
1675-1681 |
NN |
denotes |
region |
T9062 |
1664-1667 |
NN |
denotes |
SDP |
T9063 |
1668-1674 |
NN |
denotes |
repeat |
T9064 |
1682-1684 |
IN |
denotes |
in |
T9065 |
1685-1688 |
DT |
denotes |
the |
T9066 |
1705-1712 |
NN |
denotes |
protein |
T9067 |
1689-1699 |
NNP |
denotes |
Drosophila |
T9068 |
1700-1704 |
NN |
denotes |
TACC |
T9069 |
1712-1713 |
. |
denotes |
. |
T9070 |
1713-1909 |
sentence |
denotes |
This further suggests that the vertebrate TACCs have gained the specific ability to direct interact with transcriptional regulatory complexes, and that bridging protein(s) are no longer required. |
T9071 |
1714-1718 |
DT |
denotes |
This |
T9072 |
1727-1735 |
VBZ |
denotes |
suggests |
T9073 |
1719-1726 |
RB |
denotes |
further |
T9074 |
1736-1740 |
IN |
denotes |
that |
T9075 |
1767-1773 |
VBN |
denotes |
gained |
T9076 |
1741-1744 |
DT |
denotes |
the |
T9077 |
1756-1761 |
NNS |
denotes |
TACCs |
T9078 |
1745-1755 |
NN |
denotes |
vertebrate |
T9079 |
1762-1766 |
VBP |
denotes |
have |
T9080 |
1774-1777 |
DT |
denotes |
the |
T9081 |
1787-1794 |
NN |
denotes |
ability |
T9082 |
1778-1786 |
JJ |
denotes |
specific |
T9083 |
1795-1797 |
TO |
denotes |
to |
T9084 |
1805-1813 |
VB |
denotes |
interact |
T9085 |
1798-1804 |
JJ |
denotes |
direct |
T9086 |
1814-1818 |
IN |
denotes |
with |
T9087 |
1819-1834 |
JJ |
denotes |
transcriptional |
T9088 |
1846-1855 |
NNS |
denotes |
complexes |
T9089 |
1835-1845 |
JJ |
denotes |
regulatory |
T9090 |
1855-1857 |
, |
denotes |
, |
T9091 |
1857-1860 |
CC |
denotes |
and |
T9092 |
1861-1865 |
IN |
denotes |
that |
T9093 |
1900-1908 |
VBN |
denotes |
required |
T9094 |
1866-1874 |
VBG |
denotes |
bridging |
T9095 |
1875-1882 |
NN |
denotes |
protein |
T9096 |
1882-1883 |
-LRB- |
denotes |
( |
T9097 |
1883-1884 |
AFX |
denotes |
s |
T9098 |
1884-1885 |
-RRB- |
denotes |
) |
T9099 |
1886-1889 |
VBP |
denotes |
are |
T9100 |
1890-1892 |
RB |
denotes |
no |
T9101 |
1893-1899 |
RBR |
denotes |
longer |
T9102 |
1908-1909 |
. |
denotes |
. |
T9103 |
1909-2166 |
sentence |
denotes |
Thus, where the ceTAC protein is only composed of the TACC domain, the significantly larger TACC family members in higher protostomes and deuterostomes may have integrated one or more functions of the bridging protein (in this case lin15A, lin36 or lin37). |
T9104 |
1910-1914 |
RB |
denotes |
Thus |
T9105 |
2071-2081 |
VBN |
denotes |
integrated |
T9106 |
1914-1916 |
, |
denotes |
, |
T9107 |
1916-1921 |
WRB |
denotes |
where |
T9108 |
1948-1956 |
VBN |
denotes |
composed |
T9109 |
1922-1925 |
DT |
denotes |
the |
T9110 |
1932-1939 |
NN |
denotes |
protein |
T9111 |
1926-1931 |
NN |
denotes |
ceTAC |
T9112 |
1940-1942 |
VBZ |
denotes |
is |
T9113 |
1943-1947 |
RB |
denotes |
only |
T9114 |
1957-1959 |
IN |
denotes |
of |
T9115 |
1960-1963 |
DT |
denotes |
the |
T9116 |
1969-1975 |
NN |
denotes |
domain |
T9117 |
1964-1968 |
NN |
denotes |
TACC |
T9118 |
1975-1977 |
, |
denotes |
, |
T9119 |
1977-1980 |
DT |
denotes |
the |
T9120 |
2014-2021 |
NNS |
denotes |
members |
T9121 |
1981-1994 |
RB |
denotes |
significantly |
T9122 |
1995-2001 |
JJR |
denotes |
larger |
T9123 |
2002-2006 |
NN |
denotes |
TACC |
T9124 |
2007-2013 |
NN |
denotes |
family |
T9125 |
2022-2024 |
IN |
denotes |
in |
T9126 |
2025-2031 |
JJR |
denotes |
higher |
T9127 |
2032-2043 |
NNS |
denotes |
protostomes |
T9128 |
2044-2047 |
CC |
denotes |
and |
T9129 |
2048-2061 |
NNS |
denotes |
deuterostomes |
T9130 |
2062-2065 |
MD |
denotes |
may |
T9131 |
2066-2070 |
VB |
denotes |
have |
T9132 |
2082-2085 |
CD |
denotes |
one |
T9133 |
2094-2103 |
NNS |
denotes |
functions |
T9134 |
2086-2088 |
CC |
denotes |
or |
T9135 |
2089-2093 |
JJR |
denotes |
more |
T9136 |
2104-2106 |
IN |
denotes |
of |
T9137 |
2107-2110 |
DT |
denotes |
the |
T9138 |
2120-2127 |
NN |
denotes |
protein |
T9139 |
2111-2119 |
VBG |
denotes |
bridging |
T9140 |
2128-2129 |
-LRB- |
denotes |
( |
T9141 |
2129-2131 |
IN |
denotes |
in |
T9142 |
2132-2136 |
DT |
denotes |
this |
T9143 |
2137-2141 |
NN |
denotes |
case |
T9144 |
2142-2148 |
NN |
denotes |
lin15A |
T9145 |
2148-2150 |
, |
denotes |
, |
T9146 |
2150-2155 |
NN |
denotes |
lin36 |
T9147 |
2156-2158 |
CC |
denotes |
or |
T9148 |
2159-2164 |
NN |
denotes |
lin37 |
T9149 |
2164-2165 |
-RRB- |
denotes |
) |
T9150 |
2165-2166 |
. |
denotes |
. |
T9151 |
2166-2388 |
sentence |
denotes |
This may also explain the absence of lin15A, lin36 and lin37 homologues in higher organisms, as they were no longer under selective evolutionary pressure to remain within the complex, and thus lost in the evolving genome. |
T9152 |
2167-2171 |
DT |
denotes |
This |
T9153 |
2181-2188 |
VB |
denotes |
explain |
T9154 |
2172-2175 |
MD |
denotes |
may |
T9155 |
2176-2180 |
RB |
denotes |
also |
T9156 |
2189-2192 |
DT |
denotes |
the |
T9157 |
2193-2200 |
NN |
denotes |
absence |
T9158 |
2201-2203 |
IN |
denotes |
of |
T9159 |
2204-2210 |
NN |
denotes |
lin15A |
T9160 |
2228-2238 |
NNS |
denotes |
homologues |
T9161 |
2210-2212 |
, |
denotes |
, |
T9162 |
2212-2217 |
NN |
denotes |
lin36 |
T9163 |
2218-2221 |
CC |
denotes |
and |
T9164 |
2222-2227 |
NN |
denotes |
lin37 |
T9165 |
2239-2241 |
IN |
denotes |
in |
T9166 |
2242-2248 |
JJR |
denotes |
higher |
T9167 |
2249-2258 |
NNS |
denotes |
organisms |
T9168 |
2258-2260 |
, |
denotes |
, |
T9169 |
2260-2262 |
IN |
denotes |
as |
T9170 |
2268-2272 |
VBD |
denotes |
were |
T9171 |
2263-2267 |
PRP |
denotes |
they |
T9172 |
2273-2275 |
RB |
denotes |
no |
T9173 |
2276-2282 |
RBR |
denotes |
longer |
T9174 |
2283-2288 |
IN |
denotes |
under |
T9175 |
2289-2298 |
JJ |
denotes |
selective |
T9176 |
2312-2320 |
NN |
denotes |
pressure |
T9177 |
2299-2311 |
JJ |
denotes |
evolutionary |
T9178 |
2321-2323 |
TO |
denotes |
to |
T9179 |
2324-2330 |
VB |
denotes |
remain |
T9180 |
2331-2337 |
IN |
denotes |
within |
T9181 |
2338-2341 |
DT |
denotes |
the |
T9182 |
2342-2349 |
NN |
denotes |
complex |
T9183 |
2349-2351 |
, |
denotes |
, |
T9184 |
2351-2354 |
CC |
denotes |
and |
T9185 |
2355-2359 |
RB |
denotes |
thus |
T9186 |
2360-2364 |
VBN |
denotes |
lost |
T9187 |
2365-2367 |
IN |
denotes |
in |
T9188 |
2368-2371 |
DT |
denotes |
the |
T9189 |
2381-2387 |
NN |
denotes |
genome |
T9190 |
2372-2380 |
VBG |
denotes |
evolving |
T9191 |
2387-2388 |
. |
denotes |
. |
R5563 |
T8740 |
T8741 |
aux |
To,characterize |
R5564 |
T8741 |
T8743 |
advcl |
characterize,used |
R5565 |
T8742 |
T8741 |
advmod |
further,characterize |
R5566 |
T8744 |
T8745 |
det |
the,functions |
R5567 |
T8745 |
T8741 |
dobj |
functions,characterize |
R5568 |
T8746 |
T8745 |
amod |
evolving,functions |
R5569 |
T8747 |
T8745 |
prep |
of,functions |
R5570 |
T8748 |
T8749 |
det |
the,proteins |
R5571 |
T8749 |
T8747 |
pobj |
proteins,of |
R5572 |
T8750 |
T8749 |
compound |
TACC,proteins |
R5573 |
T8751 |
T8743 |
punct |
", ",used |
R5574 |
T8752 |
T8743 |
nsubj |
we,used |
R5575 |
T8753 |
T8743 |
aux |
have,used |
R5576 |
T8754 |
T8755 |
det |
an,method |
R5577 |
T8755 |
T8743 |
dobj |
method,used |
R5578 |
T8756 |
T8755 |
amod |
unbiased,method |
R5579 |
T8757 |
T8755 |
nmod |
yeast,method |
R5580 |
T8758 |
T8759 |
nummod |
two,hybrid |
R5581 |
T8759 |
T8755 |
compound |
hybrid,method |
R5582 |
T8760 |
T8755 |
compound |
screening,method |
R5583 |
T8761 |
T8762 |
aux |
to,identify |
R5584 |
T8762 |
T8743 |
advcl |
identify,used |
R5585 |
T8763 |
T8762 |
dobj |
proteins,identify |
R5586 |
T8764 |
T8765 |
dep |
that,bind |
R5587 |
T8765 |
T8763 |
relcl |
bind,proteins |
R5588 |
T8766 |
T8765 |
prep |
to,bind |
R5589 |
T8767 |
T8768 |
det |
the,proteins |
R5590 |
T8768 |
T8766 |
pobj |
proteins,to |
R5591 |
T8769 |
T8768 |
amod |
human,proteins |
R5592 |
T8770 |
T8768 |
compound |
TACC,proteins |
R5593 |
T8771 |
T8772 |
punct |
[,34 |
R5594 |
T8772 |
T8743 |
parataxis |
34,used |
R5595 |
T8773 |
T8772 |
nummod |
3,34 |
R5596 |
T8774 |
T8772 |
punct |
",",34 |
R5597 |
T8775 |
T8772 |
punct |
],34 |
R5598 |
T8776 |
T8743 |
punct |
.,used |
R5599 |
T8778 |
T8779 |
prep |
In,identified |
R5600 |
T8780 |
T8781 |
det |
a,screen |
R5601 |
T8781 |
T8778 |
pobj |
screen,In |
R5602 |
T8782 |
T8781 |
prep |
of,screen |
R5603 |
T8783 |
T8784 |
det |
a,library |
R5604 |
T8784 |
T8782 |
pobj |
library,of |
R5605 |
T8785 |
T8784 |
nmod |
MATCHMAKER,library |
R5606 |
T8786 |
T8787 |
amod |
fetal,brain |
R5607 |
T8787 |
T8784 |
compound |
brain,library |
R5608 |
T8788 |
T8789 |
punct |
(,Clontech |
R5609 |
T8789 |
T8784 |
parataxis |
Clontech,library |
R5610 |
T8790 |
T8789 |
compound |
BD,Clontech |
R5611 |
T8791 |
T8789 |
compound |
Biosciences,Clontech |
R5612 |
T8792 |
T8789 |
punct |
),Clontech |
R5613 |
T8793 |
T8779 |
punct |
", ",identified |
R5614 |
T8794 |
T8779 |
prep |
in,identified |
R5615 |
T8795 |
T8794 |
pobj |
addition,in |
R5616 |
T8796 |
T8795 |
prep |
to,addition |
R5617 |
T8797 |
T8796 |
pcomp |
isolating,to |
R5618 |
T8798 |
T8799 |
det |
the,acetyltransferase |
R5619 |
T8799 |
T8797 |
dobj |
acetyltransferase,isolating |
R5620 |
T8800 |
T8799 |
compound |
histone,acetyltransferase |
R5621 |
T8801 |
T8799 |
appos |
hGCN5L2,acetyltransferase |
R5622 |
T8802 |
T8803 |
punct |
[,34 |
R5623 |
T8803 |
T8797 |
parataxis |
34,isolating |
R5624 |
T8804 |
T8803 |
punct |
],34 |
R5625 |
T8805 |
T8779 |
punct |
", ",identified |
R5626 |
T8806 |
T8779 |
nsubj |
we,identified |
R5627 |
T8807 |
T8779 |
advmod |
also,identified |
R5628 |
T8808 |
T8809 |
det |
the,isoform |
R5629 |
T8809 |
T8779 |
dobj |
isoform,identified |
R5630 |
T8810 |
T8809 |
compound |
β3,isoform |
R5631 |
T8811 |
T8809 |
prep |
of,isoform |
R5632 |
T8812 |
T8813 |
compound |
retinoid,X |
R5633 |
T8813 |
T8815 |
compound |
X,β |
R5634 |
T8814 |
T8813 |
punct |
-,X |
R5635 |
T8815 |
T8811 |
pobj |
β,of |
R5636 |
T8816 |
T8815 |
compound |
receptor,β |
R5637 |
T8817 |
T8779 |
prep |
as,identified |
R5638 |
T8818 |
T8819 |
det |
a,protein |
R5639 |
T8819 |
T8817 |
pobj |
protein,as |
R5640 |
T8820 |
T8821 |
dep |
that,interacts |
R5641 |
T8821 |
T8819 |
relcl |
interacts,protein |
R5642 |
T8822 |
T8821 |
prep |
with,interacts |
R5643 |
T8823 |
T8824 |
det |
the,domain |
R5644 |
T8824 |
T8822 |
pobj |
domain,with |
R5645 |
T8825 |
T8824 |
compound |
TACC,domain |
R5646 |
T8826 |
T8824 |
prep |
of,domain |
R5647 |
T8827 |
T8826 |
pobj |
TACC2,of |
R5648 |
T8828 |
T8779 |
punct |
.,identified |
R5649 |
T8830 |
T8831 |
mark |
As,shown |
R5650 |
T8831 |
T8832 |
advcl |
shown,confirmed |
R5651 |
T8833 |
T8831 |
prep |
in,shown |
R5652 |
T8834 |
T8833 |
pobj |
Fig.,in |
R5653 |
T8835 |
T8834 |
nummod |
7,Fig. |
R5654 |
T8836 |
T8832 |
punct |
", ",confirmed |
R5655 |
T8837 |
T8838 |
det |
this,interaction |
R5656 |
T8838 |
T8832 |
nsubjpass |
interaction,confirmed |
R5657 |
T8839 |
T8832 |
auxpass |
is,confirmed |
R5658 |
T8840 |
T8841 |
advmod |
in,vitro |
R5659 |
T8841 |
T8832 |
advmod |
vitro,confirmed |
R5660 |
T8842 |
T8832 |
prep |
by,confirmed |
R5661 |
T8843 |
T8844 |
npadvmod |
GST,pull |
R5662 |
T8844 |
T8846 |
amod |
pull,analysis |
R5663 |
T8845 |
T8844 |
punct |
-,pull |
R5664 |
T8846 |
T8842 |
pobj |
analysis,by |
R5665 |
T8847 |
T8844 |
prt |
down,pull |
R5666 |
T8848 |
T8832 |
punct |
.,confirmed |
R5667 |
T8850 |
T8851 |
advmod |
Significantly,is |
R5668 |
T8852 |
T8851 |
punct |
", ",is |
R5669 |
T8853 |
T8851 |
nsubj |
RXRβ,is |
R5670 |
T8854 |
T8855 |
det |
a,family |
R5671 |
T8855 |
T8851 |
attr |
family,is |
R5672 |
T8856 |
T8855 |
amod |
close,family |
R5673 |
T8857 |
T8855 |
amod |
relative,family |
R5674 |
T8858 |
T8855 |
prep |
of,family |
R5675 |
T8859 |
T8860 |
det |
the,receptor |
R5676 |
T8860 |
T8858 |
pobj |
receptor,of |
R5677 |
T8861 |
T8860 |
amod |
nuclear,receptor |
R5678 |
T8862 |
T8860 |
compound |
hormone,receptor |
R5679 |
T8863 |
T8860 |
punct |
", ",receptor |
R5680 |
T8864 |
T8860 |
appos |
nhr,receptor |
R5681 |
T8865 |
T8864 |
punct |
-,nhr |
R5682 |
T8866 |
T8864 |
nummod |
86,nhr |
R5683 |
T8867 |
T8860 |
punct |
", ",receptor |
R5684 |
T8868 |
T8860 |
prep |
from,receptor |
R5685 |
T8869 |
T8870 |
compound |
C.,elegans |
R5686 |
T8870 |
T8868 |
pobj |
elegans,from |
R5687 |
T8871 |
T8870 |
punct |
", ",elegans |
R5688 |
T8872 |
T8873 |
dep |
which,interacts |
R5689 |
T8873 |
T8870 |
relcl |
interacts,elegans |
R5690 |
T8874 |
T8873 |
prep |
with,interacts |
R5691 |
T8875 |
T8876 |
det |
the,protein |
R5692 |
T8876 |
T8874 |
pobj |
protein,with |
R5693 |
T8877 |
T8876 |
compound |
ceTAC,protein |
R5694 |
T8878 |
T8876 |
compound |
binding,protein |
R5695 |
T8879 |
T8876 |
appos |
lin36,protein |
R5696 |
T8880 |
T8881 |
punct |
(,Fig. |
R5697 |
T8881 |
T8873 |
parataxis |
Fig.,interacts |
R5698 |
T8882 |
T8881 |
nummod |
6A,Fig. |
R5699 |
T8883 |
T8881 |
punct |
),Fig. |
R5700 |
T8884 |
T8851 |
punct |
.,is |
R5701 |
T8886 |
T8887 |
nsubj |
This,suggests |
R5702 |
T8888 |
T8889 |
mark |
that,evolved |
R5703 |
T8889 |
T8887 |
ccomp |
evolved,suggests |
R5704 |
T8890 |
T8891 |
mark |
while,require |
R5705 |
T8891 |
T8889 |
advcl |
require,evolved |
R5706 |
T8892 |
T8893 |
compound |
protostome,TACCs |
R5707 |
T8893 |
T8891 |
nsubj |
TACCs,require |
R5708 |
T8894 |
T8891 |
aux |
may,require |
R5709 |
T8895 |
T8896 |
amod |
additional,factors |
R5710 |
T8896 |
T8891 |
dobj |
factors,require |
R5711 |
T8897 |
T8896 |
compound |
protein,factors |
R5712 |
T8898 |
T8899 |
aux |
to,interact |
R5713 |
T8899 |
T8891 |
advcl |
interact,require |
R5714 |
T8900 |
T8899 |
prep |
with,interact |
R5715 |
T8901 |
T8902 |
amod |
such,components |
R5716 |
T8902 |
T8900 |
pobj |
components,with |
R5717 |
T8903 |
T8889 |
punct |
", ",evolved |
R5718 |
T8904 |
T8905 |
det |
the,TACCs |
R5719 |
T8905 |
T8889 |
nsubj |
TACCs,evolved |
R5720 |
T8906 |
T8905 |
prep |
in,TACCs |
R5721 |
T8907 |
T8908 |
amod |
higher,organisms |
R5722 |
T8908 |
T8906 |
pobj |
organisms,in |
R5723 |
T8909 |
T8889 |
aux |
may,evolved |
R5724 |
T8910 |
T8889 |
aux |
have,evolved |
R5725 |
T8911 |
T8912 |
det |
the,ability |
R5726 |
T8912 |
T8889 |
dobj |
ability,evolved |
R5727 |
T8913 |
T8914 |
aux |
to,interact |
R5728 |
T8914 |
T8912 |
acl |
interact,ability |
R5729 |
T8915 |
T8914 |
advmod |
directly,interact |
R5730 |
T8916 |
T8914 |
prep |
with,interact |
R5731 |
T8917 |
T8916 |
pobj |
some,with |
R5732 |
T8918 |
T8917 |
prep |
of,some |
R5733 |
T8919 |
T8920 |
det |
the,proteins |
R5734 |
T8920 |
T8918 |
pobj |
proteins,of |
R5735 |
T8921 |
T8914 |
prep |
in,interact |
R5736 |
T8922 |
T8923 |
det |
the,map |
R5737 |
T8923 |
T8921 |
pobj |
map,in |
R5738 |
T8924 |
T8923 |
amod |
predicted,map |
R5739 |
T8925 |
T8923 |
compound |
interaction,map |
R5740 |
T8926 |
T8927 |
punct |
(,Fig. |
R5741 |
T8927 |
T8887 |
parataxis |
Fig.,suggests |
R5742 |
T8928 |
T8927 |
nummod |
6E,Fig. |
R5743 |
T8929 |
T8927 |
punct |
),Fig. |
R5744 |
T8930 |
T8887 |
punct |
.,suggests |
R5745 |
T8932 |
T8933 |
advmod |
Indeed,appears |
R5746 |
T8934 |
T8933 |
punct |
", ",appears |
R5747 |
T8935 |
T8933 |
nsubj |
this,appears |
R5748 |
T8936 |
T8937 |
aux |
to,linked |
R5749 |
T8937 |
T8933 |
xcomp |
linked,appears |
R5750 |
T8938 |
T8937 |
auxpass |
be,linked |
R5751 |
T8939 |
T8937 |
advmod |
directly,linked |
R5752 |
T8940 |
T8937 |
prep |
to,linked |
R5753 |
T8941 |
T8942 |
det |
the,acquisition |
R5754 |
T8942 |
T8940 |
pobj |
acquisition,to |
R5755 |
T8943 |
T8942 |
prep |
of,acquisition |
R5756 |
T8944 |
T8945 |
amod |
new,domains |
R5757 |
T8945 |
T8943 |
pobj |
domains,of |
R5758 |
T8946 |
T8942 |
cc |
and,acquisition |
R5759 |
T8947 |
T8942 |
conj |
duplication,acquisition |
R5760 |
T8948 |
T8947 |
prep |
of,duplication |
R5761 |
T8949 |
T8950 |
det |
the,precursor |
R5762 |
T8950 |
T8948 |
pobj |
precursor,of |
R5763 |
T8951 |
T8950 |
compound |
chordate,precursor |
R5764 |
T8952 |
T8950 |
compound |
TACC,precursor |
R5765 |
T8953 |
T8933 |
punct |
.,appears |
R5766 |
T8955 |
T8956 |
prep |
In,was |
R5767 |
T8957 |
T8955 |
pobj |
fact,In |
R5768 |
T8958 |
T8956 |
punct |
", ",was |
R5769 |
T8959 |
T8960 |
det |
the,function |
R5770 |
T8960 |
T8956 |
nsubj |
function,was |
R5771 |
T8961 |
T8960 |
amod |
first,function |
R5772 |
T8962 |
T8960 |
amod |
identified,function |
R5773 |
T8963 |
T8960 |
prep |
of,function |
R5774 |
T8964 |
T8965 |
det |
a,protein |
R5775 |
T8965 |
T8963 |
pobj |
protein,of |
R5776 |
T8966 |
T8965 |
compound |
vertebrate,protein |
R5777 |
T8967 |
T8965 |
compound |
TACC,protein |
R5778 |
T8968 |
T8956 |
prep |
as,was |
R5779 |
T8969 |
T8970 |
det |
a,coactivator |
R5780 |
T8970 |
T8968 |
pobj |
coactivator,as |
R5781 |
T8971 |
T8970 |
amod |
transcriptional,coactivator |
R5782 |
T8972 |
T8970 |
acl |
acting,coactivator |
R5783 |
T8973 |
T8972 |
prep |
through,acting |
R5784 |
T8974 |
T8975 |
det |
a,interaction |
R5785 |
T8975 |
T8973 |
pobj |
interaction,through |
R5786 |
T8976 |
T8975 |
amod |
direct,interaction |
R5787 |
T8977 |
T8975 |
prep |
with,interaction |
R5788 |
T8978 |
T8979 |
det |
the,factor |
R5789 |
T8979 |
T8977 |
pobj |
factor,with |
R5790 |
T8980 |
T8979 |
compound |
ARNT,factor |
R5791 |
T8981 |
T8979 |
compound |
transcription,factor |
R5792 |
T8982 |
T8983 |
punct |
[,7 |
R5793 |
T8983 |
T8956 |
parataxis |
7,was |
R5794 |
T8984 |
T8983 |
punct |
],7 |
R5795 |
T8985 |
T8956 |
punct |
.,was |
R5796 |
T8987 |
T8988 |
nsubj |
It,is |
R5797 |
T8989 |
T8988 |
advmod |
also,is |
R5798 |
T8990 |
T8988 |
acomp |
intriguing,is |
R5799 |
T8991 |
T8992 |
mark |
that,interacts |
R5800 |
T8992 |
T8988 |
ccomp |
interacts,is |
R5801 |
T8993 |
T8994 |
det |
the,repeat |
R5802 |
T8994 |
T8992 |
nsubj |
repeat,interacts |
R5803 |
T8995 |
T8996 |
npadvmod |
deuterostome,specific |
R5804 |
T8996 |
T8994 |
amod |
specific,repeat |
R5805 |
T8997 |
T8994 |
compound |
SDP,repeat |
R5806 |
T8998 |
T8992 |
prep |
with,interacts |
R5807 |
T8999 |
T8998 |
pobj |
GAS41,with |
R5808 |
T9000 |
T8999 |
punct |
", ",GAS41 |
R5809 |
T9001 |
T9002 |
det |
a,factor |
R5810 |
T9002 |
T8999 |
appos |
factor,GAS41 |
R5811 |
T9003 |
T9004 |
compound |
component,accessory |
R5812 |
T9004 |
T9002 |
compound |
accessory,factor |
R5813 |
T9005 |
T9004 |
punct |
/,accessory |
R5814 |
T9006 |
T9002 |
prep |
of,factor |
R5815 |
T9007 |
T9008 |
det |
the,complex |
R5816 |
T9008 |
T9006 |
pobj |
complex,of |
R5817 |
T9009 |
T9008 |
amod |
human,complex |
R5818 |
T9010 |
T9011 |
compound |
SWI,SNF |
R5819 |
T9011 |
T9008 |
compound |
SNF,complex |
R5820 |
T9012 |
T9011 |
punct |
/,SNF |
R5821 |
T9013 |
T9014 |
compound |
chromatin,remodeling |
R5822 |
T9014 |
T9008 |
compound |
remodeling,complex |
R5823 |
T9015 |
T9016 |
punct |
[,15 |
R5824 |
T9016 |
T8988 |
parataxis |
15,is |
R5825 |
T9017 |
T9016 |
nummod |
3,15 |
R5826 |
T9018 |
T9016 |
punct |
",",15 |
R5827 |
T9019 |
T9016 |
punct |
],15 |
R5828 |
T9020 |
T8988 |
punct |
.,is |
R5829 |
T9022 |
T9023 |
mark |
Although,is |
R5830 |
T9023 |
T9025 |
advcl |
is,indicate |
R5831 |
T9024 |
T9023 |
expl |
there,is |
R5832 |
T9026 |
T9027 |
det |
a,homologue |
R5833 |
T9027 |
T9023 |
attr |
homologue,is |
R5834 |
T9028 |
T9029 |
compound |
D.,melanogaster |
R5835 |
T9029 |
T9027 |
compound |
melanogaster,homologue |
R5836 |
T9030 |
T9027 |
prep |
of,homologue |
R5837 |
T9031 |
T9030 |
pobj |
GAS41,of |
R5838 |
T9032 |
T9027 |
punct |
", ",homologue |
R5839 |
T9033 |
T9027 |
appos |
dmGAS41,homologue |
R5840 |
T9034 |
T9025 |
punct |
", ",indicate |
R5841 |
T9035 |
T9036 |
det |
the,database |
R5842 |
T9036 |
T9025 |
nsubj |
database,indicate |
R5843 |
T9037 |
T9038 |
amod |
large,scale |
R5844 |
T9038 |
T9039 |
nmod |
scale,interaction |
R5845 |
T9039 |
T9036 |
compound |
interaction,database |
R5846 |
T9040 |
T9039 |
amod |
proteomic,interaction |
R5847 |
T9041 |
T9025 |
aux |
does,indicate |
R5848 |
T9042 |
T9025 |
neg |
not,indicate |
R5849 |
T9043 |
T9044 |
det |
a,interaction |
R5850 |
T9044 |
T9025 |
dobj |
interaction,indicate |
R5851 |
T9045 |
T9044 |
amod |
direct,interaction |
R5852 |
T9046 |
T9044 |
prep |
of,interaction |
R5853 |
T9047 |
T9046 |
pobj |
dmGAS41,of |
R5854 |
T9048 |
T9044 |
prep |
with,interaction |
R5855 |
T9049 |
T9048 |
pobj |
DTACC,with |
R5856 |
T9050 |
T9025 |
punct |
.,indicate |
R5857 |
T9052 |
T9053 |
nsubj |
This,be |
R5858 |
T9054 |
T9053 |
aux |
may,be |
R5859 |
T9055 |
T9053 |
prep |
due,be |
R5860 |
T9056 |
T9055 |
pcomp |
to,due |
R5861 |
T9057 |
T9058 |
det |
the,lack |
R5862 |
T9058 |
T9055 |
pobj |
lack,due |
R5863 |
T9059 |
T9058 |
prep |
of,lack |
R5864 |
T9060 |
T9061 |
det |
the,region |
R5865 |
T9061 |
T9059 |
pobj |
region,of |
R5866 |
T9062 |
T9063 |
compound |
SDP,repeat |
R5867 |
T9063 |
T9061 |
compound |
repeat,region |
R5868 |
T9064 |
T9058 |
prep |
in,lack |
R5869 |
T9065 |
T9066 |
det |
the,protein |
R5870 |
T9066 |
T9064 |
pobj |
protein,in |
R5871 |
T9067 |
T9066 |
compound |
Drosophila,protein |
R5872 |
T9068 |
T9066 |
compound |
TACC,protein |
R5873 |
T9069 |
T9053 |
punct |
.,be |
R5874 |
T9071 |
T9072 |
nsubj |
This,suggests |
R5875 |
T9073 |
T9072 |
advmod |
further,suggests |
R5876 |
T9074 |
T9075 |
mark |
that,gained |
R5877 |
T9075 |
T9072 |
advcl |
gained,suggests |
R5878 |
T9076 |
T9077 |
det |
the,TACCs |
R5879 |
T9077 |
T9075 |
nsubj |
TACCs,gained |
R5880 |
T9078 |
T9077 |
compound |
vertebrate,TACCs |
R5881 |
T9079 |
T9075 |
aux |
have,gained |
R5882 |
T9080 |
T9081 |
det |
the,ability |
R5883 |
T9081 |
T9075 |
dobj |
ability,gained |
R5884 |
T9082 |
T9081 |
amod |
specific,ability |
R5885 |
T9083 |
T9084 |
aux |
to,interact |
R5886 |
T9084 |
T9081 |
acl |
interact,ability |
R5887 |
T9085 |
T9084 |
amod |
direct,interact |
R5888 |
T9086 |
T9084 |
prep |
with,interact |
R5889 |
T9087 |
T9088 |
amod |
transcriptional,complexes |
R5890 |
T9088 |
T9086 |
pobj |
complexes,with |
R5891 |
T9089 |
T9088 |
amod |
regulatory,complexes |
R5892 |
T9090 |
T9075 |
punct |
", ",gained |
R5893 |
T9091 |
T9075 |
cc |
and,gained |
R5894 |
T9092 |
T9093 |
mark |
that,required |
R5895 |
T9093 |
T9075 |
conj |
required,gained |
R5896 |
T9094 |
T9095 |
amod |
bridging,protein |
R5897 |
T9095 |
T9093 |
nsubjpass |
protein,required |
R5898 |
T9096 |
T9095 |
punct |
(,protein |
R5899 |
T9097 |
T9095 |
nmod |
s,protein |
R5900 |
T9098 |
T9095 |
punct |
),protein |
R5901 |
T9099 |
T9093 |
auxpass |
are,required |
R5902 |
T9100 |
T9101 |
neg |
no,longer |
R5903 |
T9101 |
T9093 |
advmod |
longer,required |
R5904 |
T9102 |
T9072 |
punct |
.,suggests |
R5905 |
T9104 |
T9105 |
advmod |
Thus,integrated |
R5906 |
T9106 |
T9105 |
punct |
", ",integrated |
R5907 |
T9107 |
T9108 |
advmod |
where,composed |
R5908 |
T9108 |
T9105 |
advcl |
composed,integrated |
R5909 |
T9109 |
T9110 |
det |
the,protein |
R5910 |
T9110 |
T9108 |
nsubjpass |
protein,composed |
R5911 |
T9111 |
T9110 |
compound |
ceTAC,protein |
R5912 |
T9112 |
T9108 |
auxpass |
is,composed |
R5913 |
T9113 |
T9108 |
advmod |
only,composed |
R5914 |
T9114 |
T9108 |
prep |
of,composed |
R5915 |
T9115 |
T9116 |
det |
the,domain |
R5916 |
T9116 |
T9114 |
pobj |
domain,of |
R5917 |
T9117 |
T9116 |
compound |
TACC,domain |
R5918 |
T9118 |
T9105 |
punct |
", ",integrated |
R5919 |
T9119 |
T9120 |
det |
the,members |
R5920 |
T9120 |
T9105 |
nsubj |
members,integrated |
R5921 |
T9121 |
T9122 |
advmod |
significantly,larger |
R5922 |
T9122 |
T9120 |
amod |
larger,members |
R5923 |
T9123 |
T9120 |
compound |
TACC,members |
R5924 |
T9124 |
T9120 |
compound |
family,members |
R5925 |
T9125 |
T9120 |
prep |
in,members |
R5926 |
T9126 |
T9127 |
amod |
higher,protostomes |
R5927 |
T9127 |
T9125 |
pobj |
protostomes,in |
R5928 |
T9128 |
T9127 |
cc |
and,protostomes |
R5929 |
T9129 |
T9127 |
conj |
deuterostomes,protostomes |
R5930 |
T9130 |
T9105 |
aux |
may,integrated |
R5931 |
T9131 |
T9105 |
aux |
have,integrated |
R5932 |
T9132 |
T9133 |
nummod |
one,functions |
R5933 |
T9133 |
T9105 |
dobj |
functions,integrated |
R5934 |
T9134 |
T9132 |
cc |
or,one |
R5935 |
T9135 |
T9132 |
conj |
more,one |
R5936 |
T9136 |
T9133 |
prep |
of,functions |
R5937 |
T9137 |
T9138 |
det |
the,protein |
R5938 |
T9138 |
T9136 |
pobj |
protein,of |
R5939 |
T9139 |
T9138 |
amod |
bridging,protein |
R5940 |
T9140 |
T9138 |
punct |
(,protein |
R5941 |
T9141 |
T9138 |
prep |
in,protein |
R5942 |
T9142 |
T9143 |
det |
this,case |
R5943 |
T9143 |
T9141 |
pobj |
case,in |
R5944 |
T9144 |
T9138 |
appos |
lin15A,protein |
R5945 |
T9145 |
T9144 |
punct |
", ",lin15A |
R5946 |
T9146 |
T9144 |
conj |
lin36,lin15A |
R5947 |
T9147 |
T9146 |
cc |
or,lin36 |
R5948 |
T9148 |
T9146 |
conj |
lin37,lin36 |
R5949 |
T9149 |
T9105 |
punct |
),integrated |
R5950 |
T9150 |
T9105 |
punct |
.,integrated |
R5951 |
T9152 |
T9153 |
nsubj |
This,explain |
R5952 |
T9154 |
T9153 |
aux |
may,explain |
R5953 |
T9155 |
T9153 |
advmod |
also,explain |
R5954 |
T9156 |
T9157 |
det |
the,absence |
R5955 |
T9157 |
T9153 |
dobj |
absence,explain |
R5956 |
T9158 |
T9157 |
prep |
of,absence |
R5957 |
T9159 |
T9160 |
nmod |
lin15A,homologues |
R5958 |
T9160 |
T9158 |
pobj |
homologues,of |
R5959 |
T9161 |
T9159 |
punct |
", ",lin15A |
R5960 |
T9162 |
T9159 |
conj |
lin36,lin15A |
R5961 |
T9163 |
T9162 |
cc |
and,lin36 |
R5962 |
T9164 |
T9162 |
conj |
lin37,lin36 |
R5963 |
T9165 |
T9157 |
prep |
in,absence |
R5964 |
T9166 |
T9167 |
amod |
higher,organisms |
R5965 |
T9167 |
T9165 |
pobj |
organisms,in |
R5966 |
T9168 |
T9153 |
punct |
", ",explain |
R5967 |
T9169 |
T9170 |
mark |
as,were |
R5968 |
T9170 |
T9153 |
advcl |
were,explain |
R5969 |
T9171 |
T9170 |
nsubj |
they,were |
R5970 |
T9172 |
T9173 |
neg |
no,longer |
R5971 |
T9173 |
T9170 |
advmod |
longer,were |
R5972 |
T9174 |
T9170 |
prep |
under,were |
R5973 |
T9175 |
T9176 |
amod |
selective,pressure |
R5974 |
T9176 |
T9174 |
pobj |
pressure,under |
R5975 |
T9177 |
T9176 |
amod |
evolutionary,pressure |
R5976 |
T9178 |
T9179 |
aux |
to,remain |
R5977 |
T9179 |
T9176 |
acl |
remain,pressure |
R5978 |
T9180 |
T9179 |
prep |
within,remain |
R5979 |
T9181 |
T9182 |
det |
the,complex |
R5980 |
T9182 |
T9180 |
pobj |
complex,within |
R5981 |
T9183 |
T9170 |
punct |
", ",were |
R5982 |
T9184 |
T9170 |
cc |
and,were |
R5983 |
T9185 |
T9186 |
advmod |
thus,lost |
R5984 |
T9186 |
T9170 |
conj |
lost,were |
R5985 |
T9187 |
T9186 |
prep |
in,lost |
R5986 |
T9188 |
T9189 |
det |
the,genome |
R5987 |
T9189 |
T9187 |
pobj |
genome,in |
R5988 |
T9190 |
T9189 |
amod |
evolving,genome |
R5989 |
T9191 |
T9153 |
punct |
.,explain |