Id |
Subject |
Object |
Predicate |
Lexical cue |
T8332 |
0-10 |
NN |
denotes |
Comparison |
T8333 |
11-13 |
IN |
denotes |
of |
T8334 |
14-21 |
VBN |
denotes |
modeled |
T8335 |
22-26 |
IN |
denotes |
with |
T8336 |
27-41 |
RB |
denotes |
experimentally |
T8337 |
42-49 |
VBN |
denotes |
defined |
T8338 |
50-62 |
NNS |
denotes |
interactions |
T8339 |
63-65 |
IN |
denotes |
of |
T8340 |
66-69 |
DT |
denotes |
the |
T8341 |
86-94 |
NN |
denotes |
proteins |
T8342 |
70-80 |
NN |
denotes |
vertebrate |
T8343 |
81-85 |
NN |
denotes |
TACC |
T8344 |
94-222 |
sentence |
denotes |
The interaction data for the vertebrate TACCs is relatively limited; however, interaction networks are now beginning to emerge. |
T8345 |
95-98 |
DT |
denotes |
The |
T8346 |
111-115 |
NNS |
denotes |
data |
T8347 |
99-110 |
NN |
denotes |
interaction |
T8348 |
141-143 |
VBZ |
denotes |
is |
T8349 |
116-119 |
IN |
denotes |
for |
T8350 |
120-123 |
DT |
denotes |
the |
T8351 |
135-140 |
NNS |
denotes |
TACCs |
T8352 |
124-134 |
NN |
denotes |
vertebrate |
T8353 |
202-211 |
VBG |
denotes |
beginning |
T8354 |
144-154 |
RB |
denotes |
relatively |
T8355 |
155-162 |
VBN |
denotes |
limited |
T8356 |
162-163 |
: |
denotes |
; |
T8357 |
164-171 |
RB |
denotes |
however |
T8358 |
171-173 |
, |
denotes |
, |
T8359 |
173-184 |
NN |
denotes |
interaction |
T8360 |
185-193 |
NNS |
denotes |
networks |
T8361 |
194-197 |
VBP |
denotes |
are |
T8362 |
198-201 |
RB |
denotes |
now |
T8363 |
212-214 |
TO |
denotes |
to |
T8364 |
215-221 |
VB |
denotes |
emerge |
T8365 |
221-222 |
. |
denotes |
. |
T8366 |
222-408 |
sentence |
denotes |
The results of our functional analysis, as well as other published data clearly indicate that the vertebrate TACCs interact with proteins that can be divided into two broad categories: |
T8367 |
223-226 |
DT |
denotes |
The |
T8368 |
227-234 |
NNS |
denotes |
results |
T8369 |
303-311 |
VBP |
denotes |
indicate |
T8370 |
235-237 |
IN |
denotes |
of |
T8371 |
238-241 |
PRP$ |
denotes |
our |
T8372 |
253-261 |
NN |
denotes |
analysis |
T8373 |
242-252 |
JJ |
denotes |
functional |
T8374 |
261-263 |
, |
denotes |
, |
T8375 |
263-265 |
RB |
denotes |
as |
T8376 |
271-273 |
IN |
denotes |
as |
T8377 |
266-270 |
RB |
denotes |
well |
T8378 |
274-279 |
JJ |
denotes |
other |
T8379 |
290-294 |
NNS |
denotes |
data |
T8380 |
280-289 |
VBN |
denotes |
published |
T8381 |
295-302 |
RB |
denotes |
clearly |
T8382 |
312-316 |
IN |
denotes |
that |
T8383 |
338-346 |
VBP |
denotes |
interact |
T8384 |
317-320 |
DT |
denotes |
the |
T8385 |
332-337 |
NNS |
denotes |
TACCs |
T8386 |
321-331 |
NN |
denotes |
vertebrate |
T8387 |
347-351 |
IN |
denotes |
with |
T8388 |
352-360 |
NN |
denotes |
proteins |
T8389 |
361-365 |
WDT |
denotes |
that |
T8390 |
373-380 |
VBN |
denotes |
divided |
T8391 |
366-369 |
MD |
denotes |
can |
T8392 |
370-372 |
VB |
denotes |
be |
T8393 |
381-385 |
IN |
denotes |
into |
T8394 |
386-389 |
CD |
denotes |
two |
T8395 |
396-406 |
NNS |
denotes |
categories |
T8396 |
390-395 |
JJ |
denotes |
broad |
T8397 |
406-408 |
: |
denotes |
: |
T8398 |
408-409 |
LS |
denotes |
1 |
T8399 |
411-419 |
NN |
denotes |
proteins |
T8400 |
408-628 |
sentence |
denotes |
1) proteins with roles in centrosome/mitotic spindle dynamics, and 2) proteins involved in gene regulation, either at the level of transcription, or subsequent RNA processing and translation [3,5-7,15,19-21,24,25,33,34]. |
T8401 |
409-410 |
-RRB- |
denotes |
) |
T8402 |
420-424 |
IN |
denotes |
with |
T8403 |
425-430 |
NNS |
denotes |
roles |
T8404 |
431-433 |
IN |
denotes |
in |
T8405 |
434-444 |
NN |
denotes |
centrosome |
T8406 |
445-452 |
JJ |
denotes |
mitotic |
T8407 |
444-445 |
HYPH |
denotes |
/ |
T8408 |
453-460 |
NN |
denotes |
spindle |
T8409 |
461-469 |
NNS |
denotes |
dynamics |
T8410 |
469-471 |
, |
denotes |
, |
T8411 |
471-474 |
CC |
denotes |
and |
T8412 |
475-476 |
LS |
denotes |
2 |
T8413 |
478-486 |
NN |
denotes |
proteins |
T8414 |
476-477 |
-RRB- |
denotes |
) |
T8415 |
487-495 |
VBN |
denotes |
involved |
T8416 |
496-498 |
IN |
denotes |
in |
T8417 |
499-503 |
NN |
denotes |
gene |
T8418 |
504-514 |
NN |
denotes |
regulation |
T8419 |
514-516 |
, |
denotes |
, |
T8420 |
516-522 |
CC |
denotes |
either |
T8421 |
523-525 |
IN |
denotes |
at |
T8422 |
526-529 |
DT |
denotes |
the |
T8423 |
530-535 |
NN |
denotes |
level |
T8424 |
536-538 |
IN |
denotes |
of |
T8425 |
539-552 |
NN |
denotes |
transcription |
T8426 |
552-554 |
, |
denotes |
, |
T8427 |
554-556 |
CC |
denotes |
or |
T8428 |
557-567 |
JJ |
denotes |
subsequent |
T8429 |
572-582 |
NN |
denotes |
processing |
T8430 |
568-571 |
NN |
denotes |
RNA |
T8431 |
583-586 |
CC |
denotes |
and |
T8432 |
587-598 |
NN |
denotes |
translation |
T8433 |
599-600 |
-LRB- |
denotes |
[ |
T8434 |
600-601 |
CD |
denotes |
3 |
T8435 |
601-602 |
, |
denotes |
, |
T8436 |
602-603 |
CD |
denotes |
5 |
T8437 |
603-604 |
SYM |
denotes |
- |
T8438 |
604-605 |
CD |
denotes |
7 |
T8439 |
605-606 |
, |
denotes |
, |
T8440 |
606-608 |
CD |
denotes |
15 |
T8441 |
608-609 |
, |
denotes |
, |
T8442 |
609-611 |
CD |
denotes |
19 |
T8443 |
611-612 |
SYM |
denotes |
- |
T8444 |
612-614 |
CD |
denotes |
21 |
T8445 |
614-615 |
, |
denotes |
, |
T8446 |
615-617 |
CD |
denotes |
24 |
T8447 |
617-618 |
, |
denotes |
, |
T8448 |
618-620 |
CD |
denotes |
25 |
T8449 |
620-621 |
, |
denotes |
, |
T8450 |
621-623 |
CD |
denotes |
33 |
T8451 |
623-624 |
, |
denotes |
, |
T8452 |
624-626 |
CD |
denotes |
34 |
T8453 |
626-627 |
-RRB- |
denotes |
] |
T8454 |
627-628 |
. |
denotes |
. |
T8455 |
628-783 |
sentence |
denotes |
Many of these proteins do not appear to interact directly with the protostome TACCs, but would be expected to be in the same protein complex (Fig. 6C,6D). |
T8456 |
629-633 |
JJ |
denotes |
Many |
T8457 |
659-665 |
VB |
denotes |
appear |
T8458 |
634-636 |
IN |
denotes |
of |
T8459 |
637-642 |
DT |
denotes |
these |
T8460 |
643-651 |
NN |
denotes |
proteins |
T8461 |
652-654 |
VBP |
denotes |
do |
T8462 |
655-658 |
RB |
denotes |
not |
T8463 |
666-668 |
TO |
denotes |
to |
T8464 |
669-677 |
VB |
denotes |
interact |
T8465 |
678-686 |
RB |
denotes |
directly |
T8466 |
687-691 |
IN |
denotes |
with |
T8467 |
692-695 |
DT |
denotes |
the |
T8468 |
707-712 |
NNS |
denotes |
TACCs |
T8469 |
696-706 |
NN |
denotes |
protostome |
T8470 |
712-714 |
, |
denotes |
, |
T8471 |
714-717 |
CC |
denotes |
but |
T8472 |
718-723 |
MD |
denotes |
would |
T8473 |
727-735 |
VBN |
denotes |
expected |
T8474 |
724-726 |
VB |
denotes |
be |
T8475 |
736-738 |
TO |
denotes |
to |
T8476 |
739-741 |
VB |
denotes |
be |
T8477 |
742-744 |
IN |
denotes |
in |
T8478 |
745-748 |
DT |
denotes |
the |
T8479 |
762-769 |
NN |
denotes |
complex |
T8480 |
749-753 |
JJ |
denotes |
same |
T8481 |
754-761 |
NN |
denotes |
protein |
T8482 |
770-771 |
-LRB- |
denotes |
( |
T8483 |
779-781 |
CD |
denotes |
6D |
T8484 |
771-775 |
NN |
denotes |
Fig. |
T8485 |
776-778 |
CD |
denotes |
6C |
T8486 |
778-779 |
, |
denotes |
, |
T8487 |
781-782 |
-RRB- |
denotes |
) |
T8488 |
782-783 |
. |
denotes |
. |
T8489 |
783-954 |
sentence |
denotes |
Significant analysis of the association of the TACCs with the centrosome and the dynamics of mitotic spindle assembly from yeast to humans has been published [5,6,21-24]. |
T8490 |
784-795 |
JJ |
denotes |
Significant |
T8491 |
796-804 |
NN |
denotes |
analysis |
T8492 |
932-941 |
VBN |
denotes |
published |
T8493 |
805-807 |
IN |
denotes |
of |
T8494 |
808-811 |
DT |
denotes |
the |
T8495 |
812-823 |
NN |
denotes |
association |
T8496 |
824-826 |
IN |
denotes |
of |
T8497 |
827-830 |
DT |
denotes |
the |
T8498 |
831-836 |
NNS |
denotes |
TACCs |
T8499 |
837-841 |
IN |
denotes |
with |
T8500 |
842-845 |
DT |
denotes |
the |
T8501 |
846-856 |
NN |
denotes |
centrosome |
T8502 |
857-860 |
CC |
denotes |
and |
T8503 |
861-864 |
DT |
denotes |
the |
T8504 |
865-873 |
NNS |
denotes |
dynamics |
T8505 |
874-876 |
IN |
denotes |
of |
T8506 |
877-884 |
JJ |
denotes |
mitotic |
T8507 |
885-892 |
NN |
denotes |
spindle |
T8508 |
893-901 |
NN |
denotes |
assembly |
T8509 |
902-906 |
IN |
denotes |
from |
T8510 |
907-912 |
NN |
denotes |
yeast |
T8511 |
913-915 |
IN |
denotes |
to |
T8512 |
916-922 |
NNS |
denotes |
humans |
T8513 |
923-926 |
VBZ |
denotes |
has |
T8514 |
927-931 |
VBN |
denotes |
been |
T8515 |
942-943 |
-LRB- |
denotes |
[ |
T8516 |
943-944 |
CD |
denotes |
5 |
T8517 |
944-945 |
, |
denotes |
, |
T8518 |
945-946 |
CD |
denotes |
6 |
T8519 |
946-947 |
, |
denotes |
, |
T8520 |
947-949 |
CD |
denotes |
21 |
T8521 |
949-950 |
SYM |
denotes |
- |
T8522 |
950-952 |
CD |
denotes |
24 |
T8523 |
952-953 |
-RRB- |
denotes |
] |
T8524 |
953-954 |
. |
denotes |
. |
T8525 |
954-1274 |
sentence |
denotes |
From this analysis, it seems likely that the vertebrate TACC3 protein has retained this direct ancestral function, based upon its location in these structures during mitosis [27], its strong interaction with Aurora Kinase A, and the observation that it is the only human TACC protein phosphorylated by this enzyme [21]. |
T8526 |
955-959 |
IN |
denotes |
From |
T8527 |
978-983 |
VBZ |
denotes |
seems |
T8528 |
960-964 |
DT |
denotes |
this |
T8529 |
965-973 |
NN |
denotes |
analysis |
T8530 |
973-975 |
, |
denotes |
, |
T8531 |
975-977 |
PRP |
denotes |
it |
T8532 |
984-990 |
JJ |
denotes |
likely |
T8533 |
991-995 |
IN |
denotes |
that |
T8534 |
1029-1037 |
VBN |
denotes |
retained |
T8535 |
996-999 |
DT |
denotes |
the |
T8536 |
1017-1024 |
NN |
denotes |
protein |
T8537 |
1000-1010 |
NN |
denotes |
vertebrate |
T8538 |
1011-1016 |
NN |
denotes |
TACC3 |
T8539 |
1025-1028 |
VBZ |
denotes |
has |
T8540 |
1038-1042 |
DT |
denotes |
this |
T8541 |
1060-1068 |
NN |
denotes |
function |
T8542 |
1043-1049 |
JJ |
denotes |
direct |
T8543 |
1050-1059 |
JJ |
denotes |
ancestral |
T8544 |
1068-1070 |
, |
denotes |
, |
T8545 |
1070-1075 |
VBN |
denotes |
based |
T8546 |
1076-1080 |
IN |
denotes |
upon |
T8547 |
1081-1084 |
PRP$ |
denotes |
its |
T8548 |
1085-1093 |
NN |
denotes |
location |
T8549 |
1094-1096 |
IN |
denotes |
in |
T8550 |
1097-1102 |
DT |
denotes |
these |
T8551 |
1103-1113 |
NNS |
denotes |
structures |
T8552 |
1114-1120 |
IN |
denotes |
during |
T8553 |
1121-1128 |
NN |
denotes |
mitosis |
T8554 |
1129-1130 |
-LRB- |
denotes |
[ |
T8555 |
1130-1132 |
CD |
denotes |
27 |
T8556 |
1132-1133 |
-RRB- |
denotes |
] |
T8557 |
1133-1135 |
, |
denotes |
, |
T8558 |
1135-1138 |
PRP$ |
denotes |
its |
T8559 |
1146-1157 |
NN |
denotes |
interaction |
T8560 |
1139-1145 |
JJ |
denotes |
strong |
T8561 |
1158-1162 |
IN |
denotes |
with |
T8562 |
1163-1169 |
NN |
denotes |
Aurora |
T8563 |
1177-1178 |
NN |
denotes |
A |
T8564 |
1170-1176 |
NN |
denotes |
Kinase |
T8565 |
1178-1180 |
, |
denotes |
, |
T8566 |
1180-1183 |
CC |
denotes |
and |
T8567 |
1184-1187 |
DT |
denotes |
the |
T8568 |
1188-1199 |
NN |
denotes |
observation |
T8569 |
1200-1204 |
IN |
denotes |
that |
T8570 |
1208-1210 |
VBZ |
denotes |
is |
T8571 |
1205-1207 |
PRP |
denotes |
it |
T8572 |
1211-1214 |
DT |
denotes |
the |
T8573 |
1231-1238 |
NN |
denotes |
protein |
T8574 |
1215-1219 |
RB |
denotes |
only |
T8575 |
1220-1225 |
JJ |
denotes |
human |
T8576 |
1226-1230 |
NN |
denotes |
TACC |
T8577 |
1239-1253 |
VBN |
denotes |
phosphorylated |
T8578 |
1254-1256 |
IN |
denotes |
by |
T8579 |
1257-1261 |
DT |
denotes |
this |
T8580 |
1262-1268 |
NN |
denotes |
enzyme |
T8581 |
1269-1270 |
-LRB- |
denotes |
[ |
T8582 |
1270-1272 |
CD |
denotes |
21 |
T8583 |
1272-1273 |
-RRB- |
denotes |
] |
T8584 |
1273-1274 |
. |
denotes |
. |
T8585 |
1274-1458 |
sentence |
denotes |
However, the variability of the central domain of the vertebrate orthologues, suggests that TACC3 may also have acquired additional, and in some instances, species-specific functions. |
T8586 |
1275-1282 |
RB |
denotes |
However |
T8587 |
1353-1361 |
VBZ |
denotes |
suggests |
T8588 |
1282-1284 |
, |
denotes |
, |
T8589 |
1284-1287 |
DT |
denotes |
the |
T8590 |
1288-1299 |
NN |
denotes |
variability |
T8591 |
1300-1302 |
IN |
denotes |
of |
T8592 |
1303-1306 |
DT |
denotes |
the |
T8593 |
1315-1321 |
NN |
denotes |
domain |
T8594 |
1307-1314 |
JJ |
denotes |
central |
T8595 |
1322-1324 |
IN |
denotes |
of |
T8596 |
1325-1328 |
DT |
denotes |
the |
T8597 |
1340-1351 |
NNS |
denotes |
orthologues |
T8598 |
1329-1339 |
NN |
denotes |
vertebrate |
T8599 |
1351-1353 |
, |
denotes |
, |
T8600 |
1362-1366 |
IN |
denotes |
that |
T8601 |
1387-1395 |
VBN |
denotes |
acquired |
T8602 |
1367-1372 |
NN |
denotes |
TACC3 |
T8603 |
1373-1376 |
MD |
denotes |
may |
T8604 |
1377-1381 |
RB |
denotes |
also |
T8605 |
1382-1386 |
VB |
denotes |
have |
T8606 |
1396-1406 |
JJ |
denotes |
additional |
T8607 |
1448-1457 |
NNS |
denotes |
functions |
T8608 |
1406-1408 |
, |
denotes |
, |
T8609 |
1408-1411 |
CC |
denotes |
and |
T8610 |
1412-1414 |
IN |
denotes |
in |
T8611 |
1439-1447 |
JJ |
denotes |
specific |
T8612 |
1415-1419 |
DT |
denotes |
some |
T8613 |
1420-1429 |
NNS |
denotes |
instances |
T8614 |
1429-1431 |
, |
denotes |
, |
T8615 |
1431-1438 |
NN |
denotes |
species |
T8616 |
1438-1439 |
HYPH |
denotes |
- |
T8617 |
1457-1458 |
. |
denotes |
. |
T8618 |
1458-1668 |
sentence |
denotes |
For instance, in X. laevis, the maskin protein has acquired a binding site for the eIF4E protein, and thus a function in the coordinated control of polyadenylation and translation in the Xenopus oocyte [8,35]. |
T8619 |
1459-1462 |
IN |
denotes |
For |
T8620 |
1510-1518 |
VBN |
denotes |
acquired |
T8621 |
1463-1471 |
NN |
denotes |
instance |
T8622 |
1471-1473 |
, |
denotes |
, |
T8623 |
1473-1475 |
IN |
denotes |
in |
T8624 |
1476-1478 |
NNP |
denotes |
X. |
T8625 |
1479-1485 |
NNP |
denotes |
laevis |
T8626 |
1485-1487 |
, |
denotes |
, |
T8627 |
1487-1490 |
DT |
denotes |
the |
T8628 |
1498-1505 |
NN |
denotes |
protein |
T8629 |
1491-1497 |
NN |
denotes |
maskin |
T8630 |
1506-1509 |
VBZ |
denotes |
has |
T8631 |
1519-1520 |
DT |
denotes |
a |
T8632 |
1529-1533 |
NN |
denotes |
site |
T8633 |
1521-1528 |
NN |
denotes |
binding |
T8634 |
1534-1537 |
IN |
denotes |
for |
T8635 |
1538-1541 |
DT |
denotes |
the |
T8636 |
1548-1555 |
NN |
denotes |
protein |
T8637 |
1542-1547 |
NN |
denotes |
eIF4E |
T8638 |
1555-1557 |
, |
denotes |
, |
T8639 |
1557-1560 |
CC |
denotes |
and |
T8640 |
1561-1565 |
RB |
denotes |
thus |
T8641 |
1568-1576 |
NN |
denotes |
function |
T8642 |
1566-1567 |
DT |
denotes |
a |
T8643 |
1577-1579 |
IN |
denotes |
in |
T8644 |
1580-1583 |
DT |
denotes |
the |
T8645 |
1596-1603 |
NN |
denotes |
control |
T8646 |
1584-1595 |
VBN |
denotes |
coordinated |
T8647 |
1604-1606 |
IN |
denotes |
of |
T8648 |
1607-1622 |
NN |
denotes |
polyadenylation |
T8649 |
1623-1626 |
CC |
denotes |
and |
T8650 |
1627-1638 |
NN |
denotes |
translation |
T8651 |
1639-1641 |
IN |
denotes |
in |
T8652 |
1642-1645 |
DT |
denotes |
the |
T8653 |
1654-1660 |
NN |
denotes |
oocyte |
T8654 |
1646-1653 |
NNP |
denotes |
Xenopus |
T8655 |
1661-1662 |
-LRB- |
denotes |
[ |
T8656 |
1664-1666 |
CD |
denotes |
35 |
T8657 |
1662-1663 |
CD |
denotes |
8 |
T8658 |
1663-1664 |
, |
denotes |
, |
T8659 |
1666-1667 |
-RRB- |
denotes |
] |
T8660 |
1667-1668 |
. |
denotes |
. |
T8661 |
1668-1922 |
sentence |
denotes |
A recent study has suggested that this function may be unique to maskin: although it is unclear whether the other vertebrate TACC3 proteins interact with the eIF4E/CPEB complex, the human TACC1A isoform is unable to interact with the eIF4E/CPEB complex. |
T8662 |
1669-1670 |
DT |
denotes |
A |
T8663 |
1678-1683 |
NN |
denotes |
study |
T8664 |
1671-1677 |
JJ |
denotes |
recent |
T8665 |
1688-1697 |
VBN |
denotes |
suggested |
T8666 |
1684-1687 |
VBZ |
denotes |
has |
T8667 |
1872-1874 |
VBZ |
denotes |
is |
T8668 |
1698-1702 |
IN |
denotes |
that |
T8669 |
1721-1723 |
VB |
denotes |
be |
T8670 |
1703-1707 |
DT |
denotes |
this |
T8671 |
1708-1716 |
NN |
denotes |
function |
T8672 |
1717-1720 |
MD |
denotes |
may |
T8673 |
1724-1730 |
JJ |
denotes |
unique |
T8674 |
1731-1733 |
IN |
denotes |
to |
T8675 |
1734-1740 |
NN |
denotes |
maskin |
T8676 |
1740-1742 |
: |
denotes |
: |
T8677 |
1742-1750 |
IN |
denotes |
although |
T8678 |
1754-1756 |
VBZ |
denotes |
is |
T8679 |
1751-1753 |
PRP |
denotes |
it |
T8680 |
1757-1764 |
JJ |
denotes |
unclear |
T8681 |
1765-1772 |
IN |
denotes |
whether |
T8682 |
1809-1817 |
VBP |
denotes |
interact |
T8683 |
1773-1776 |
DT |
denotes |
the |
T8684 |
1800-1808 |
NN |
denotes |
proteins |
T8685 |
1777-1782 |
JJ |
denotes |
other |
T8686 |
1783-1793 |
NN |
denotes |
vertebrate |
T8687 |
1794-1799 |
NN |
denotes |
TACC3 |
T8688 |
1818-1822 |
IN |
denotes |
with |
T8689 |
1823-1826 |
DT |
denotes |
the |
T8690 |
1838-1845 |
NN |
denotes |
complex |
T8691 |
1827-1832 |
NN |
denotes |
eIF4E |
T8692 |
1833-1837 |
NN |
denotes |
CPEB |
T8693 |
1832-1833 |
HYPH |
denotes |
/ |
T8694 |
1845-1847 |
, |
denotes |
, |
T8695 |
1847-1850 |
DT |
denotes |
the |
T8696 |
1864-1871 |
NN |
denotes |
isoform |
T8697 |
1851-1856 |
JJ |
denotes |
human |
T8698 |
1857-1863 |
NN |
denotes |
TACC1A |
T8699 |
1875-1881 |
JJ |
denotes |
unable |
T8700 |
1882-1884 |
TO |
denotes |
to |
T8701 |
1885-1893 |
VB |
denotes |
interact |
T8702 |
1894-1898 |
IN |
denotes |
with |
T8703 |
1899-1902 |
DT |
denotes |
the |
T8704 |
1914-1921 |
NN |
denotes |
complex |
T8705 |
1903-1908 |
NN |
denotes |
eIF4E |
T8706 |
1909-1913 |
NN |
denotes |
CPEB |
T8707 |
1908-1909 |
HYPH |
denotes |
/ |
T8708 |
1921-1922 |
. |
denotes |
. |
T8709 |
1922-2085 |
sentence |
denotes |
Instead, some TACC1 isoforms have evolved a related, but distinct function by directly interacting with elements of the RNA splicing and transport machinery [19]. |
T8710 |
1923-1930 |
RB |
denotes |
Instead |
T8711 |
1957-1964 |
VBN |
denotes |
evolved |
T8712 |
1930-1932 |
, |
denotes |
, |
T8713 |
1932-1936 |
DT |
denotes |
some |
T8714 |
1943-1951 |
NNS |
denotes |
isoforms |
T8715 |
1937-1942 |
NN |
denotes |
TACC1 |
T8716 |
1952-1956 |
VBP |
denotes |
have |
T8717 |
1965-1966 |
DT |
denotes |
a |
T8718 |
1989-1997 |
NN |
denotes |
function |
T8719 |
1967-1974 |
JJ |
denotes |
related |
T8720 |
1974-1976 |
, |
denotes |
, |
T8721 |
1976-1979 |
CC |
denotes |
but |
T8722 |
1980-1988 |
JJ |
denotes |
distinct |
T8723 |
1998-2000 |
IN |
denotes |
by |
T8724 |
2001-2009 |
RB |
denotes |
directly |
T8725 |
2010-2021 |
VBG |
denotes |
interacting |
T8726 |
2022-2026 |
IN |
denotes |
with |
T8727 |
2027-2035 |
NNS |
denotes |
elements |
T8728 |
2036-2038 |
IN |
denotes |
of |
T8729 |
2039-2042 |
DT |
denotes |
the |
T8730 |
2070-2079 |
NN |
denotes |
machinery |
T8731 |
2043-2046 |
NN |
denotes |
RNA |
T8732 |
2047-2055 |
NN |
denotes |
splicing |
T8733 |
2056-2059 |
CC |
denotes |
and |
T8734 |
2060-2069 |
NN |
denotes |
transport |
T8735 |
2080-2081 |
-LRB- |
denotes |
[ |
T8736 |
2081-2083 |
CD |
denotes |
19 |
T8737 |
2083-2084 |
-RRB- |
denotes |
] |
T8738 |
2084-2085 |
. |
denotes |
. |
T8739 |
2085-2279 |
sentence |
denotes |
To further characterize the evolving functions of the TACC proteins, we have used an unbiased yeast two hybrid screening method to identify proteins that bind to the human TACC proteins [3,34]. |
T8740 |
2086-2088 |
TO |
denotes |
To |
T8741 |
2097-2109 |
VB |
denotes |
characterize |
T8742 |
2089-2096 |
RB |
denotes |
further |
T8743 |
2163-2167 |
VBN |
denotes |
used |
T8744 |
2110-2113 |
DT |
denotes |
the |
T8745 |
2123-2132 |
NNS |
denotes |
functions |
T8746 |
2114-2122 |
VBG |
denotes |
evolving |
T8747 |
2133-2135 |
IN |
denotes |
of |
T8748 |
2136-2139 |
DT |
denotes |
the |
T8749 |
2145-2153 |
NN |
denotes |
proteins |
T8750 |
2140-2144 |
NN |
denotes |
TACC |
T8751 |
2153-2155 |
, |
denotes |
, |
T8752 |
2155-2157 |
PRP |
denotes |
we |
T8753 |
2158-2162 |
VBP |
denotes |
have |
T8754 |
2168-2170 |
DT |
denotes |
an |
T8755 |
2207-2213 |
NN |
denotes |
method |
T8756 |
2171-2179 |
JJ |
denotes |
unbiased |
T8757 |
2180-2185 |
NN |
denotes |
yeast |
T8758 |
2186-2189 |
CD |
denotes |
two |
T8759 |
2190-2196 |
NN |
denotes |
hybrid |
T8760 |
2197-2206 |
NN |
denotes |
screening |
T8761 |
2214-2216 |
TO |
denotes |
to |
T8762 |
2217-2225 |
VB |
denotes |
identify |
T8763 |
2226-2234 |
NN |
denotes |
proteins |
T8764 |
2235-2239 |
WDT |
denotes |
that |
T8765 |
2240-2244 |
VBP |
denotes |
bind |
T8766 |
2245-2247 |
IN |
denotes |
to |
T8767 |
2248-2251 |
DT |
denotes |
the |
T8768 |
2263-2271 |
NN |
denotes |
proteins |
T8769 |
2252-2257 |
JJ |
denotes |
human |
T8770 |
2258-2262 |
NN |
denotes |
TACC |
T8771 |
2272-2273 |
-LRB- |
denotes |
[ |
T8772 |
2275-2277 |
CD |
denotes |
34 |
T8773 |
2273-2274 |
CD |
denotes |
3 |
T8774 |
2274-2275 |
, |
denotes |
, |
T8775 |
2277-2278 |
-RRB- |
denotes |
] |
T8776 |
2278-2279 |
. |
denotes |
. |
T8777 |
2279-2541 |
sentence |
denotes |
In a screen of a MATCHMAKER fetal brain library (BD Biosciences Clontech), in addition to isolating the histone acetyltransferase hGCN5L2 [34], we also identified the β3 isoform of retinoid-X receptor β as a protein that interacts with the TACC domain of TACC2. |
T8778 |
2280-2282 |
IN |
denotes |
In |
T8779 |
2432-2442 |
VBD |
denotes |
identified |
T8780 |
2283-2284 |
DT |
denotes |
a |
T8781 |
2285-2291 |
NN |
denotes |
screen |
T8782 |
2292-2294 |
IN |
denotes |
of |
T8783 |
2295-2296 |
DT |
denotes |
a |
T8784 |
2320-2327 |
NN |
denotes |
library |
T8785 |
2297-2307 |
NN |
denotes |
MATCHMAKER |
T8786 |
2308-2313 |
JJ |
denotes |
fetal |
T8787 |
2314-2319 |
NN |
denotes |
brain |
T8788 |
2328-2329 |
-LRB- |
denotes |
( |
T8789 |
2344-2352 |
NNP |
denotes |
Clontech |
T8790 |
2329-2331 |
NNP |
denotes |
BD |
T8791 |
2332-2343 |
NNPS |
denotes |
Biosciences |
T8792 |
2352-2353 |
-RRB- |
denotes |
) |
T8793 |
2353-2355 |
, |
denotes |
, |
T8794 |
2355-2357 |
IN |
denotes |
in |
T8795 |
2358-2366 |
NN |
denotes |
addition |
T8796 |
2367-2369 |
IN |
denotes |
to |
T8797 |
2370-2379 |
VBG |
denotes |
isolating |
T8798 |
2380-2383 |
DT |
denotes |
the |
T8799 |
2392-2409 |
NN |
denotes |
acetyltransferase |
T8800 |
2384-2391 |
NN |
denotes |
histone |
T8801 |
2410-2417 |
NN |
denotes |
hGCN5L2 |
T8802 |
2418-2419 |
-LRB- |
denotes |
[ |
T8803 |
2419-2421 |
CD |
denotes |
34 |
T8804 |
2421-2422 |
-RRB- |
denotes |
] |
T8805 |
2422-2424 |
, |
denotes |
, |
T8806 |
2424-2426 |
PRP |
denotes |
we |
T8807 |
2427-2431 |
RB |
denotes |
also |
T8808 |
2443-2446 |
DT |
denotes |
the |
T8809 |
2450-2457 |
NN |
denotes |
isoform |
T8810 |
2447-2449 |
NN |
denotes |
β3 |
T8811 |
2458-2460 |
IN |
denotes |
of |
T8812 |
2461-2469 |
NN |
denotes |
retinoid |
T8813 |
2470-2471 |
NN |
denotes |
X |
T8814 |
2469-2470 |
HYPH |
denotes |
- |
T8815 |
2481-2482 |
NN |
denotes |
β |
T8816 |
2472-2480 |
NN |
denotes |
receptor |
T8817 |
2483-2485 |
IN |
denotes |
as |
T8818 |
2486-2487 |
DT |
denotes |
a |
T8819 |
2488-2495 |
NN |
denotes |
protein |
T8820 |
2496-2500 |
WDT |
denotes |
that |
T8821 |
2501-2510 |
VBZ |
denotes |
interacts |
T8822 |
2511-2515 |
IN |
denotes |
with |
T8823 |
2516-2519 |
DT |
denotes |
the |
T8824 |
2525-2531 |
NN |
denotes |
domain |
T8825 |
2520-2524 |
NN |
denotes |
TACC |
T8826 |
2532-2534 |
IN |
denotes |
of |
T8827 |
2535-2540 |
NN |
denotes |
TACC2 |
T8828 |
2540-2541 |
. |
denotes |
. |
T8829 |
2541-2627 |
sentence |
denotes |
As shown in Fig. 7, this interaction is confirmed in vitro by GST-pull down analysis. |
T8830 |
2542-2544 |
IN |
denotes |
As |
T8831 |
2545-2550 |
VBN |
denotes |
shown |
T8832 |
2582-2591 |
VBN |
denotes |
confirmed |
T8833 |
2551-2553 |
IN |
denotes |
in |
T8834 |
2554-2558 |
NN |
denotes |
Fig. |
T8835 |
2559-2560 |
CD |
denotes |
7 |
T8836 |
2560-2562 |
, |
denotes |
, |
T8837 |
2562-2566 |
DT |
denotes |
this |
T8838 |
2567-2578 |
NN |
denotes |
interaction |
T8839 |
2579-2581 |
VBZ |
denotes |
is |
T8840 |
2592-2594 |
FW |
denotes |
in |
T8841 |
2595-2600 |
FW |
denotes |
vitro |
T8842 |
2601-2603 |
IN |
denotes |
by |
T8843 |
2604-2607 |
NN |
denotes |
GST |
T8844 |
2608-2612 |
VB |
denotes |
pull |
T8845 |
2607-2608 |
HYPH |
denotes |
- |
T8846 |
2618-2626 |
NN |
denotes |
analysis |
T8847 |
2613-2617 |
RP |
denotes |
down |
T8848 |
2626-2627 |
. |
denotes |
. |
T8849 |
2627-2796 |
sentence |
denotes |
Significantly, RXRβ is a close family relative of the nuclear hormone receptor, nhr-86, from C. elegans, which interacts with the ceTAC binding protein lin36 (Fig. 6A). |
T8850 |
2628-2641 |
RB |
denotes |
Significantly |
T8851 |
2648-2650 |
VBZ |
denotes |
is |
T8852 |
2641-2643 |
, |
denotes |
, |
T8853 |
2643-2647 |
NN |
denotes |
RXRβ |
T8854 |
2651-2652 |
DT |
denotes |
a |
T8855 |
2659-2665 |
NN |
denotes |
family |
T8856 |
2653-2658 |
JJ |
denotes |
close |
T8857 |
2666-2674 |
JJ |
denotes |
relative |
T8858 |
2675-2677 |
IN |
denotes |
of |
T8859 |
2678-2681 |
DT |
denotes |
the |
T8860 |
2698-2706 |
NN |
denotes |
receptor |
T8861 |
2682-2689 |
JJ |
denotes |
nuclear |
T8862 |
2690-2697 |
NN |
denotes |
hormone |
T8863 |
2706-2708 |
, |
denotes |
, |
T8864 |
2708-2711 |
NN |
denotes |
nhr |
T8865 |
2711-2712 |
HYPH |
denotes |
- |
T8866 |
2712-2714 |
CD |
denotes |
86 |
T8867 |
2714-2716 |
, |
denotes |
, |
T8868 |
2716-2720 |
IN |
denotes |
from |
T8869 |
2721-2723 |
NNP |
denotes |
C. |
T8870 |
2724-2731 |
NNP |
denotes |
elegans |
T8871 |
2731-2733 |
, |
denotes |
, |
T8872 |
2733-2738 |
WDT |
denotes |
which |
T8873 |
2739-2748 |
VBZ |
denotes |
interacts |
T8874 |
2749-2753 |
IN |
denotes |
with |
T8875 |
2754-2757 |
DT |
denotes |
the |
T8876 |
2772-2779 |
NN |
denotes |
protein |
T8877 |
2758-2763 |
NN |
denotes |
ceTAC |
T8878 |
2764-2771 |
NN |
denotes |
binding |
T8879 |
2780-2785 |
NN |
denotes |
lin36 |
T8880 |
2786-2787 |
-LRB- |
denotes |
( |
T8881 |
2787-2791 |
NN |
denotes |
Fig. |
T8882 |
2792-2794 |
CD |
denotes |
6A |
T8883 |
2794-2795 |
-RRB- |
denotes |
) |
T8884 |
2795-2796 |
. |
denotes |
. |
T8885 |
2796-3061 |
sentence |
denotes |
This suggests that while protostome TACCs may require additional protein factors to interact with such components, the TACCs in higher organisms may have evolved the ability to directly interact with some of the proteins in the predicted interaction map (Fig. 6E). |
T8886 |
2797-2801 |
DT |
denotes |
This |
T8887 |
2802-2810 |
VBZ |
denotes |
suggests |
T8888 |
2811-2815 |
IN |
denotes |
that |
T8889 |
2951-2958 |
VBN |
denotes |
evolved |
T8890 |
2816-2821 |
IN |
denotes |
while |
T8891 |
2843-2850 |
VB |
denotes |
require |
T8892 |
2822-2832 |
NN |
denotes |
protostome |
T8893 |
2833-2838 |
NNS |
denotes |
TACCs |
T8894 |
2839-2842 |
MD |
denotes |
may |
T8895 |
2851-2861 |
JJ |
denotes |
additional |
T8896 |
2870-2877 |
NNS |
denotes |
factors |
T8897 |
2862-2869 |
NN |
denotes |
protein |
T8898 |
2878-2880 |
TO |
denotes |
to |
T8899 |
2881-2889 |
VB |
denotes |
interact |
T8900 |
2890-2894 |
IN |
denotes |
with |
T8901 |
2895-2899 |
JJ |
denotes |
such |
T8902 |
2900-2910 |
NNS |
denotes |
components |
T8903 |
2910-2912 |
, |
denotes |
, |
T8904 |
2912-2915 |
DT |
denotes |
the |
T8905 |
2916-2921 |
NNS |
denotes |
TACCs |
T8906 |
2922-2924 |
IN |
denotes |
in |
T8907 |
2925-2931 |
JJR |
denotes |
higher |
T8908 |
2932-2941 |
NNS |
denotes |
organisms |
T8909 |
2942-2945 |
MD |
denotes |
may |
T8910 |
2946-2950 |
VB |
denotes |
have |
T8911 |
2959-2962 |
DT |
denotes |
the |
T8912 |
2963-2970 |
NN |
denotes |
ability |
T8913 |
2971-2973 |
TO |
denotes |
to |
T8914 |
2983-2991 |
VB |
denotes |
interact |
T8915 |
2974-2982 |
RB |
denotes |
directly |
T8916 |
2992-2996 |
IN |
denotes |
with |
T8917 |
2997-3001 |
DT |
denotes |
some |
T8918 |
3002-3004 |
IN |
denotes |
of |
T8919 |
3005-3008 |
DT |
denotes |
the |
T8920 |
3009-3017 |
NN |
denotes |
proteins |
T8921 |
3018-3020 |
IN |
denotes |
in |
T8922 |
3021-3024 |
DT |
denotes |
the |
T8923 |
3047-3050 |
NN |
denotes |
map |
T8924 |
3025-3034 |
VBN |
denotes |
predicted |
T8925 |
3035-3046 |
NN |
denotes |
interaction |
T8926 |
3051-3052 |
-LRB- |
denotes |
( |
T8927 |
3052-3056 |
NN |
denotes |
Fig. |
T8928 |
3057-3059 |
CD |
denotes |
6E |
T8929 |
3059-3060 |
-RRB- |
denotes |
) |
T8930 |
3060-3061 |
. |
denotes |
. |
T8931 |
3061-3186 |
sentence |
denotes |
Indeed, this appears to be directly linked to the acquisition of new domains and duplication of the chordate TACC precursor. |
T8932 |
3062-3068 |
RB |
denotes |
Indeed |
T8933 |
3075-3082 |
VBZ |
denotes |
appears |
T8934 |
3068-3070 |
, |
denotes |
, |
T8935 |
3070-3074 |
DT |
denotes |
this |
T8936 |
3083-3085 |
TO |
denotes |
to |
T8937 |
3098-3104 |
VBN |
denotes |
linked |
T8938 |
3086-3088 |
VB |
denotes |
be |
T8939 |
3089-3097 |
RB |
denotes |
directly |
T8940 |
3105-3107 |
IN |
denotes |
to |
T8941 |
3108-3111 |
DT |
denotes |
the |
T8942 |
3112-3123 |
NN |
denotes |
acquisition |
T8943 |
3124-3126 |
IN |
denotes |
of |
T8944 |
3127-3130 |
JJ |
denotes |
new |
T8945 |
3131-3138 |
NNS |
denotes |
domains |
T8946 |
3139-3142 |
CC |
denotes |
and |
T8947 |
3143-3154 |
NN |
denotes |
duplication |
T8948 |
3155-3157 |
IN |
denotes |
of |
T8949 |
3158-3161 |
DT |
denotes |
the |
T8950 |
3176-3185 |
NN |
denotes |
precursor |
T8951 |
3162-3170 |
NN |
denotes |
chordate |
T8952 |
3171-3175 |
NN |
denotes |
TACC |
T8953 |
3185-3186 |
. |
denotes |
. |
T8954 |
3186-3367 |
sentence |
denotes |
In fact, the first identified function of a vertebrate TACC protein was as a transcriptional coactivator acting through a direct interaction with the ARNT transcription factor [7]. |
T8955 |
3187-3189 |
IN |
denotes |
In |
T8956 |
3255-3258 |
VBD |
denotes |
was |
T8957 |
3190-3194 |
NN |
denotes |
fact |
T8958 |
3194-3196 |
, |
denotes |
, |
T8959 |
3196-3199 |
DT |
denotes |
the |
T8960 |
3217-3225 |
NN |
denotes |
function |
T8961 |
3200-3205 |
JJ |
denotes |
first |
T8962 |
3206-3216 |
VBN |
denotes |
identified |
T8963 |
3226-3228 |
IN |
denotes |
of |
T8964 |
3229-3230 |
DT |
denotes |
a |
T8965 |
3247-3254 |
NN |
denotes |
protein |
T8966 |
3231-3241 |
NN |
denotes |
vertebrate |
T8967 |
3242-3246 |
NN |
denotes |
TACC |
T8968 |
3259-3261 |
IN |
denotes |
as |
T8969 |
3262-3263 |
DT |
denotes |
a |
T8970 |
3280-3291 |
NN |
denotes |
coactivator |
T8971 |
3264-3279 |
JJ |
denotes |
transcriptional |
T8972 |
3292-3298 |
VBG |
denotes |
acting |
T8973 |
3299-3306 |
IN |
denotes |
through |
T8974 |
3307-3308 |
DT |
denotes |
a |
T8975 |
3316-3327 |
NN |
denotes |
interaction |
T8976 |
3309-3315 |
JJ |
denotes |
direct |
T8977 |
3328-3332 |
IN |
denotes |
with |
T8978 |
3333-3336 |
DT |
denotes |
the |
T8979 |
3356-3362 |
NN |
denotes |
factor |
T8980 |
3337-3341 |
NN |
denotes |
ARNT |
T8981 |
3342-3355 |
NN |
denotes |
transcription |
T8982 |
3363-3364 |
-LRB- |
denotes |
[ |
T8983 |
3364-3365 |
CD |
denotes |
7 |
T8984 |
3365-3366 |
-RRB- |
denotes |
] |
T8985 |
3366-3367 |
. |
denotes |
. |
T8986 |
3367-3540 |
sentence |
denotes |
It is also intriguing that the deuterostome specific SDP repeat interacts with GAS41, a component/accessory factor of the human SWI/SNF chromatin remodeling complex [3,15]. |
T8987 |
3368-3370 |
PRP |
denotes |
It |
T8988 |
3371-3373 |
VBZ |
denotes |
is |
T8989 |
3374-3378 |
RB |
denotes |
also |
T8990 |
3379-3389 |
JJ |
denotes |
intriguing |
T8991 |
3390-3394 |
IN |
denotes |
that |
T8992 |
3432-3441 |
VBZ |
denotes |
interacts |
T8993 |
3395-3398 |
DT |
denotes |
the |
T8994 |
3425-3431 |
NN |
denotes |
repeat |
T8995 |
3399-3411 |
NN |
denotes |
deuterostome |
T8996 |
3412-3420 |
JJ |
denotes |
specific |
T8997 |
3421-3424 |
NN |
denotes |
SDP |
T8998 |
3442-3446 |
IN |
denotes |
with |
T8999 |
3447-3452 |
NN |
denotes |
GAS41 |
T9000 |
3452-3454 |
, |
denotes |
, |
T9001 |
3454-3455 |
DT |
denotes |
a |
T9002 |
3476-3482 |
NN |
denotes |
factor |
T9003 |
3456-3465 |
NN |
denotes |
component |
T9004 |
3466-3475 |
NN |
denotes |
accessory |
T9005 |
3465-3466 |
HYPH |
denotes |
/ |
T9006 |
3483-3485 |
IN |
denotes |
of |
T9007 |
3486-3489 |
DT |
denotes |
the |
T9008 |
3525-3532 |
NN |
denotes |
complex |
T9009 |
3490-3495 |
JJ |
denotes |
human |
T9010 |
3496-3499 |
NN |
denotes |
SWI |
T9011 |
3500-3503 |
NN |
denotes |
SNF |
T9012 |
3499-3500 |
HYPH |
denotes |
/ |
T9013 |
3504-3513 |
NN |
denotes |
chromatin |
T9014 |
3514-3524 |
NN |
denotes |
remodeling |
T9015 |
3533-3534 |
-LRB- |
denotes |
[ |
T9016 |
3536-3538 |
CD |
denotes |
15 |
T9017 |
3534-3535 |
CD |
denotes |
3 |
T9018 |
3535-3536 |
, |
denotes |
, |
T9019 |
3538-3539 |
-RRB- |
denotes |
] |
T9020 |
3539-3540 |
. |
denotes |
. |
T9021 |
3540-3714 |
sentence |
denotes |
Although there is a D. melanogaster homologue of GAS41, dmGAS41, the large scale proteomic interaction database does not indicate a direct interaction of dmGAS41 with DTACC. |
T9022 |
3541-3549 |
IN |
denotes |
Although |
T9023 |
3556-3558 |
VBZ |
denotes |
is |
T9024 |
3550-3555 |
EX |
denotes |
there |
T9025 |
3662-3670 |
VB |
denotes |
indicate |
T9026 |
3559-3560 |
DT |
denotes |
a |
T9027 |
3577-3586 |
NN |
denotes |
homologue |
T9028 |
3561-3563 |
NNP |
denotes |
D. |
T9029 |
3564-3576 |
NNP |
denotes |
melanogaster |
T9030 |
3587-3589 |
IN |
denotes |
of |
T9031 |
3590-3595 |
NN |
denotes |
GAS41 |
T9032 |
3595-3597 |
, |
denotes |
, |
T9033 |
3597-3604 |
NN |
denotes |
dmGAS41 |
T9034 |
3604-3606 |
, |
denotes |
, |
T9035 |
3606-3609 |
DT |
denotes |
the |
T9036 |
3644-3652 |
NN |
denotes |
database |
T9037 |
3610-3615 |
JJ |
denotes |
large |
T9038 |
3616-3621 |
NN |
denotes |
scale |
T9039 |
3632-3643 |
NN |
denotes |
interaction |
T9040 |
3622-3631 |
JJ |
denotes |
proteomic |
T9041 |
3653-3657 |
VBZ |
denotes |
does |
T9042 |
3658-3661 |
RB |
denotes |
not |
T9043 |
3671-3672 |
DT |
denotes |
a |
T9044 |
3680-3691 |
NN |
denotes |
interaction |
T9045 |
3673-3679 |
JJ |
denotes |
direct |
T9046 |
3692-3694 |
IN |
denotes |
of |
T9047 |
3695-3702 |
NN |
denotes |
dmGAS41 |
T9048 |
3703-3707 |
IN |
denotes |
with |
T9049 |
3708-3713 |
NN |
denotes |
DTACC |
T9050 |
3713-3714 |
. |
denotes |
. |
T9051 |
3714-3799 |
sentence |
denotes |
This may be due to the lack of the SDP repeat region in the Drosophila TACC protein. |
T9052 |
3715-3719 |
DT |
denotes |
This |
T9053 |
3724-3726 |
VB |
denotes |
be |
T9054 |
3720-3723 |
MD |
denotes |
may |
T9055 |
3727-3730 |
IN |
denotes |
due |
T9056 |
3731-3733 |
IN |
denotes |
to |
T9057 |
3734-3737 |
DT |
denotes |
the |
T9058 |
3738-3742 |
NN |
denotes |
lack |
T9059 |
3743-3745 |
IN |
denotes |
of |
T9060 |
3746-3749 |
DT |
denotes |
the |
T9061 |
3761-3767 |
NN |
denotes |
region |
T9062 |
3750-3753 |
NN |
denotes |
SDP |
T9063 |
3754-3760 |
NN |
denotes |
repeat |
T9064 |
3768-3770 |
IN |
denotes |
in |
T9065 |
3771-3774 |
DT |
denotes |
the |
T9066 |
3791-3798 |
NN |
denotes |
protein |
T9067 |
3775-3785 |
NNP |
denotes |
Drosophila |
T9068 |
3786-3790 |
NN |
denotes |
TACC |
T9069 |
3798-3799 |
. |
denotes |
. |
T9070 |
3799-3995 |
sentence |
denotes |
This further suggests that the vertebrate TACCs have gained the specific ability to direct interact with transcriptional regulatory complexes, and that bridging protein(s) are no longer required. |
T9071 |
3800-3804 |
DT |
denotes |
This |
T9072 |
3813-3821 |
VBZ |
denotes |
suggests |
T9073 |
3805-3812 |
RB |
denotes |
further |
T9074 |
3822-3826 |
IN |
denotes |
that |
T9075 |
3853-3859 |
VBN |
denotes |
gained |
T9076 |
3827-3830 |
DT |
denotes |
the |
T9077 |
3842-3847 |
NNS |
denotes |
TACCs |
T9078 |
3831-3841 |
NN |
denotes |
vertebrate |
T9079 |
3848-3852 |
VBP |
denotes |
have |
T9080 |
3860-3863 |
DT |
denotes |
the |
T9081 |
3873-3880 |
NN |
denotes |
ability |
T9082 |
3864-3872 |
JJ |
denotes |
specific |
T9083 |
3881-3883 |
TO |
denotes |
to |
T9084 |
3891-3899 |
VB |
denotes |
interact |
T9085 |
3884-3890 |
JJ |
denotes |
direct |
T9086 |
3900-3904 |
IN |
denotes |
with |
T9087 |
3905-3920 |
JJ |
denotes |
transcriptional |
T9088 |
3932-3941 |
NNS |
denotes |
complexes |
T9089 |
3921-3931 |
JJ |
denotes |
regulatory |
T9090 |
3941-3943 |
, |
denotes |
, |
T9091 |
3943-3946 |
CC |
denotes |
and |
T9092 |
3947-3951 |
IN |
denotes |
that |
T9093 |
3986-3994 |
VBN |
denotes |
required |
T9094 |
3952-3960 |
VBG |
denotes |
bridging |
T9095 |
3961-3968 |
NN |
denotes |
protein |
T9096 |
3968-3969 |
-LRB- |
denotes |
( |
T9097 |
3969-3970 |
AFX |
denotes |
s |
T9098 |
3970-3971 |
-RRB- |
denotes |
) |
T9099 |
3972-3975 |
VBP |
denotes |
are |
T9100 |
3976-3978 |
RB |
denotes |
no |
T9101 |
3979-3985 |
RBR |
denotes |
longer |
T9102 |
3994-3995 |
. |
denotes |
. |
T9103 |
3995-4252 |
sentence |
denotes |
Thus, where the ceTAC protein is only composed of the TACC domain, the significantly larger TACC family members in higher protostomes and deuterostomes may have integrated one or more functions of the bridging protein (in this case lin15A, lin36 or lin37). |
T9104 |
3996-4000 |
RB |
denotes |
Thus |
T9105 |
4157-4167 |
VBN |
denotes |
integrated |
T9106 |
4000-4002 |
, |
denotes |
, |
T9107 |
4002-4007 |
WRB |
denotes |
where |
T9108 |
4034-4042 |
VBN |
denotes |
composed |
T9109 |
4008-4011 |
DT |
denotes |
the |
T9110 |
4018-4025 |
NN |
denotes |
protein |
T9111 |
4012-4017 |
NN |
denotes |
ceTAC |
T9112 |
4026-4028 |
VBZ |
denotes |
is |
T9113 |
4029-4033 |
RB |
denotes |
only |
T9114 |
4043-4045 |
IN |
denotes |
of |
T9115 |
4046-4049 |
DT |
denotes |
the |
T9116 |
4055-4061 |
NN |
denotes |
domain |
T9117 |
4050-4054 |
NN |
denotes |
TACC |
T9118 |
4061-4063 |
, |
denotes |
, |
T9119 |
4063-4066 |
DT |
denotes |
the |
T9120 |
4100-4107 |
NNS |
denotes |
members |
T9121 |
4067-4080 |
RB |
denotes |
significantly |
T9122 |
4081-4087 |
JJR |
denotes |
larger |
T9123 |
4088-4092 |
NN |
denotes |
TACC |
T9124 |
4093-4099 |
NN |
denotes |
family |
T9125 |
4108-4110 |
IN |
denotes |
in |
T9126 |
4111-4117 |
JJR |
denotes |
higher |
T9127 |
4118-4129 |
NNS |
denotes |
protostomes |
T9128 |
4130-4133 |
CC |
denotes |
and |
T9129 |
4134-4147 |
NNS |
denotes |
deuterostomes |
T9130 |
4148-4151 |
MD |
denotes |
may |
T9131 |
4152-4156 |
VB |
denotes |
have |
T9132 |
4168-4171 |
CD |
denotes |
one |
T9133 |
4180-4189 |
NNS |
denotes |
functions |
T9134 |
4172-4174 |
CC |
denotes |
or |
T9135 |
4175-4179 |
JJR |
denotes |
more |
T9136 |
4190-4192 |
IN |
denotes |
of |
T9137 |
4193-4196 |
DT |
denotes |
the |
T9138 |
4206-4213 |
NN |
denotes |
protein |
T9139 |
4197-4205 |
VBG |
denotes |
bridging |
T9140 |
4214-4215 |
-LRB- |
denotes |
( |
T9141 |
4215-4217 |
IN |
denotes |
in |
T9142 |
4218-4222 |
DT |
denotes |
this |
T9143 |
4223-4227 |
NN |
denotes |
case |
T9144 |
4228-4234 |
NN |
denotes |
lin15A |
T9145 |
4234-4236 |
, |
denotes |
, |
T9146 |
4236-4241 |
NN |
denotes |
lin36 |
T9147 |
4242-4244 |
CC |
denotes |
or |
T9148 |
4245-4250 |
NN |
denotes |
lin37 |
T9149 |
4250-4251 |
-RRB- |
denotes |
) |
T9150 |
4251-4252 |
. |
denotes |
. |
T9151 |
4252-4474 |
sentence |
denotes |
This may also explain the absence of lin15A, lin36 and lin37 homologues in higher organisms, as they were no longer under selective evolutionary pressure to remain within the complex, and thus lost in the evolving genome. |
T9152 |
4253-4257 |
DT |
denotes |
This |
T9153 |
4267-4274 |
VB |
denotes |
explain |
T9154 |
4258-4261 |
MD |
denotes |
may |
T9155 |
4262-4266 |
RB |
denotes |
also |
T9156 |
4275-4278 |
DT |
denotes |
the |
T9157 |
4279-4286 |
NN |
denotes |
absence |
T9158 |
4287-4289 |
IN |
denotes |
of |
T9159 |
4290-4296 |
NN |
denotes |
lin15A |
T9160 |
4314-4324 |
NNS |
denotes |
homologues |
T9161 |
4296-4298 |
, |
denotes |
, |
T9162 |
4298-4303 |
NN |
denotes |
lin36 |
T9163 |
4304-4307 |
CC |
denotes |
and |
T9164 |
4308-4313 |
NN |
denotes |
lin37 |
T9165 |
4325-4327 |
IN |
denotes |
in |
T9166 |
4328-4334 |
JJR |
denotes |
higher |
T9167 |
4335-4344 |
NNS |
denotes |
organisms |
T9168 |
4344-4346 |
, |
denotes |
, |
T9169 |
4346-4348 |
IN |
denotes |
as |
T9170 |
4354-4358 |
VBD |
denotes |
were |
T9171 |
4349-4353 |
PRP |
denotes |
they |
T9172 |
4359-4361 |
RB |
denotes |
no |
T9173 |
4362-4368 |
RBR |
denotes |
longer |
T9174 |
4369-4374 |
IN |
denotes |
under |
T9175 |
4375-4384 |
JJ |
denotes |
selective |
T9176 |
4398-4406 |
NN |
denotes |
pressure |
T9177 |
4385-4397 |
JJ |
denotes |
evolutionary |
T9178 |
4407-4409 |
TO |
denotes |
to |
T9179 |
4410-4416 |
VB |
denotes |
remain |
T9180 |
4417-4423 |
IN |
denotes |
within |
T9181 |
4424-4427 |
DT |
denotes |
the |
T9182 |
4428-4435 |
NN |
denotes |
complex |
T9183 |
4435-4437 |
, |
denotes |
, |
T9184 |
4437-4440 |
CC |
denotes |
and |
T9185 |
4441-4445 |
RB |
denotes |
thus |
T9186 |
4446-4450 |
VBN |
denotes |
lost |
T9187 |
4451-4453 |
IN |
denotes |
in |
T9188 |
4454-4457 |
DT |
denotes |
the |
T9189 |
4467-4473 |
NN |
denotes |
genome |
T9190 |
4458-4466 |
VBG |
denotes |
evolving |
T9191 |
4473-4474 |
. |
denotes |
. |
T13918 |
4677-4681 |
NN |
denotes |
Lane |
T13919 |
4682-4683 |
CD |
denotes |
3 |
T13920 |
4683-4685 |
SYM |
denotes |
: |
T13921 |
4685-4686 |
CD |
denotes |
5 |
T13922 |
4686-4687 |
NN |
denotes |
% |
T13923 |
4694-4696 |
IN |
denotes |
of |
T13924 |
4697-4699 |
FW |
denotes |
in |
T13925 |
4700-4705 |
FW |
denotes |
vitro |
T13926 |
4723-4730 |
NN |
denotes |
protein |
T13927 |
4706-4716 |
VBN |
denotes |
translated |
T13928 |
4717-4720 |
NN |
denotes |
RXR |
T13929 |
4721-4722 |
NN |
denotes |
β |
T13930 |
4720-4721 |
HYPH |
denotes |
- |
T13931 |
4730-4731 |
. |
denotes |
. |
T13932 |
4731-4849 |
sentence |
denotes |
Bottom two panels represent Coomassie blue stained gels of pull down experiment showing loading of GST-TACC2 and GST. |
T13933 |
4732-4738 |
JJ |
denotes |
Bottom |
T13934 |
4743-4749 |
NNS |
denotes |
panels |
T13935 |
4739-4742 |
CD |
denotes |
two |
T13936 |
4750-4759 |
VBP |
denotes |
represent |
T13937 |
4760-4769 |
NNP |
denotes |
Coomassie |
T13938 |
4783-4787 |
NNS |
denotes |
gels |
T13939 |
4770-4774 |
JJ |
denotes |
blue |
T13940 |
4775-4782 |
VBN |
denotes |
stained |
T13941 |
4788-4790 |
IN |
denotes |
of |
T13942 |
4791-4795 |
VB |
denotes |
pull |
T13943 |
4801-4811 |
NN |
denotes |
experiment |
T13944 |
4796-4800 |
RP |
denotes |
down |
T13945 |
4812-4819 |
VBG |
denotes |
showing |
T13946 |
4820-4827 |
NN |
denotes |
loading |
T13947 |
4828-4830 |
IN |
denotes |
of |
T13948 |
4831-4834 |
NN |
denotes |
GST |
T13949 |
4835-4840 |
NN |
denotes |
TACC2 |
T13950 |
4834-4835 |
HYPH |
denotes |
- |
T13951 |
4841-4844 |
CC |
denotes |
and |
T13952 |
4845-4848 |
NN |
denotes |
GST |
T13953 |
4848-4849 |
. |
denotes |
. |
T13889 |
4553-4555 |
IN |
denotes |
of |
T13890 |
4556-4558 |
CD |
denotes |
12 |
T13891 |
4558-4559 |
NN |
denotes |
% |
T13892 |
4560-4563 |
NN |
denotes |
SDS |
T13893 |
4579-4582 |
NN |
denotes |
gel |
T13894 |
4564-4578 |
NN |
denotes |
polyacrylamide |
T13895 |
4583-4587 |
IN |
denotes |
with |
T13896 |
4588-4590 |
FW |
denotes |
in |
T13897 |
4591-4596 |
FW |
denotes |
vitro |
T13898 |
4597-4607 |
VBN |
denotes |
translated |
T13899 |
4614-4623 |
NN |
denotes |
construct |
T13900 |
4608-4613 |
NN |
denotes |
RXRβ3 |
T13901 |
4624-4630 |
VBN |
denotes |
pulled |
T13902 |
4631-4635 |
RP |
denotes |
down |
T13903 |
4636-4640 |
IN |
denotes |
with |
T13904 |
4641-4644 |
NN |
denotes |
GST |
T13905 |
4645-4650 |
NN |
denotes |
TACC2 |
T13906 |
4644-4645 |
HYPH |
denotes |
- |
T13907 |
4651-4652 |
-LRB- |
denotes |
( |
T13908 |
4652-4656 |
NN |
denotes |
Lane |
T13909 |
4657-4658 |
CD |
denotes |
1 |
T13910 |
4658-4659 |
-RRB- |
denotes |
) |
T13911 |
4660-4662 |
CC |
denotes |
or |
T13912 |
4663-4666 |
NN |
denotes |
GST |
T13913 |
4667-4668 |
-LRB- |
denotes |
( |
T13914 |
4668-4672 |
NN |
denotes |
Lane |
T13915 |
4673-4674 |
CD |
denotes |
2 |
T13916 |
4674-4675 |
-RRB- |
denotes |
) |
T13917 |
4675-4676 |
: |
denotes |
; |
T13875 |
4485-4487 |
FW |
denotes |
In |
T13876 |
4488-4493 |
FW |
denotes |
vitro |
T13877 |
4494-4505 |
NN |
denotes |
interaction |
T13878 |
4506-4508 |
IN |
denotes |
of |
T13879 |
4509-4514 |
NN |
denotes |
RXRβ3 |
T13880 |
4515-4518 |
CC |
denotes |
and |
T13881 |
4519-4525 |
NNS |
denotes |
TACC2s |
T13882 |
4525-4526 |
. |
denotes |
. |
T13883 |
4526-4731 |
sentence |
denotes |
Top panel: Autoradiograph of 12% SDS polyacrylamide gel with in vitro translated RXRβ3 construct pulled down with GST-TACC2 (Lane 1) or GST (Lane 2); Lane 3: 5% input of in vitro translated RXR-β protein. |
T13884 |
4527-4530 |
JJ |
denotes |
Top |
T13885 |
4531-4536 |
NN |
denotes |
panel |
T13886 |
4538-4552 |
NN |
denotes |
Autoradiograph |
T13887 |
4536-4538 |
: |
denotes |
: |
T13888 |
4688-4693 |
NN |
denotes |
input |
R8999 |
T13879 |
T13878 |
pobj |
RXRβ3,of |
R9000 |
T13880 |
T13879 |
cc |
and,RXRβ3 |
R9001 |
T13881 |
T13879 |
conj |
TACC2s,RXRβ3 |
R9002 |
T13882 |
T13877 |
punct |
.,interaction |
R9003 |
T13884 |
T13885 |
amod |
Top,panel |
R9004 |
T13885 |
T13886 |
dep |
panel,Autoradiograph |
R9005 |
T13886 |
T13888 |
dep |
Autoradiograph,input |
R9006 |
T13887 |
T13886 |
punct |
: ,Autoradiograph |
R9007 |
T13889 |
T13886 |
prep |
of,Autoradiograph |
R9008 |
T13890 |
T13891 |
nummod |
12,% |
R9009 |
T13891 |
T13892 |
compound |
%,SDS |
R9010 |
T13892 |
T13893 |
compound |
SDS,gel |
R9011 |
T13893 |
T13889 |
pobj |
gel,of |
R9012 |
T13894 |
T13893 |
compound |
polyacrylamide,gel |
R9013 |
T13895 |
T13886 |
prep |
with,Autoradiograph |
R9014 |
T13896 |
T13897 |
advmod |
in,vitro |
R9015 |
T13897 |
T13898 |
advmod |
vitro,translated |
R9016 |
T13898 |
T13899 |
amod |
translated,construct |
R9017 |
T13899 |
T13895 |
pobj |
construct,with |
R9018 |
T13900 |
T13899 |
compound |
RXRβ3,construct |
R9019 |
T13901 |
T13899 |
acl |
pulled,construct |
R9020 |
T13902 |
T13901 |
prt |
down,pulled |
R9021 |
T13903 |
T13901 |
prep |
with,pulled |
R9022 |
T13904 |
T13905 |
compound |
GST,TACC2 |
R9023 |
T13905 |
T13903 |
pobj |
TACC2,with |
R9024 |
T13906 |
T13905 |
punct |
-,TACC2 |
R9025 |
T13907 |
T13908 |
punct |
(,Lane |
R9026 |
T13908 |
T13905 |
parataxis |
Lane,TACC2 |
R9027 |
T13909 |
T13908 |
nummod |
1,Lane |
R9028 |
T13910 |
T13908 |
punct |
),Lane |
R9029 |
T13911 |
T13905 |
cc |
or,TACC2 |
R9030 |
T13912 |
T13905 |
conj |
GST,TACC2 |
R9031 |
T13913 |
T13914 |
punct |
(,Lane |
R9032 |
T13914 |
T13912 |
parataxis |
Lane,GST |
R9033 |
T13915 |
T13914 |
nummod |
2,Lane |
R9034 |
T13916 |
T13914 |
punct |
),Lane |
R9035 |
T13917 |
T13888 |
punct |
;,input |
R9036 |
T13918 |
T13888 |
dep |
Lane,input |
R9037 |
T13919 |
T13918 |
nummod |
3,Lane |
R9038 |
T13920 |
T13888 |
punct |
: ,input |
R9039 |
T13921 |
T13888 |
nummod |
5,input |
R9040 |
T13922 |
T13888 |
compound |
%,input |
R9041 |
T13923 |
T13888 |
prep |
of,input |
R9042 |
T13924 |
T13925 |
advmod |
in,vitro |
R9043 |
T13925 |
T13926 |
amod |
vitro,protein |
R9044 |
T13926 |
T13923 |
pobj |
protein,of |
R9045 |
T13927 |
T13926 |
amod |
translated,protein |
R9046 |
T13928 |
T13929 |
compound |
RXR,β |
R9047 |
T13929 |
T13926 |
compound |
β,protein |
R9048 |
T13930 |
T13929 |
punct |
-,β |
R9049 |
T13931 |
T13888 |
punct |
.,input |
R9050 |
T13933 |
T13934 |
amod |
Bottom,panels |
R9051 |
T13934 |
T13936 |
nsubj |
panels,represent |
R9052 |
T13935 |
T13934 |
nummod |
two,panels |
R9053 |
T13937 |
T13938 |
nmod |
Coomassie,gels |
R9054 |
T13938 |
T13936 |
dobj |
gels,represent |
R9055 |
T13939 |
T13940 |
amod |
blue,stained |
R9056 |
T13940 |
T13938 |
amod |
stained,gels |
R9057 |
T13941 |
T13938 |
prep |
of,gels |
R9058 |
T13942 |
T13943 |
amod |
pull,experiment |
R9059 |
T13943 |
T13941 |
pobj |
experiment,of |
R9060 |
T13944 |
T13942 |
prt |
down,pull |
R9061 |
T13945 |
T13943 |
acl |
showing,experiment |
R9062 |
T13946 |
T13945 |
dobj |
loading,showing |
R9063 |
T13947 |
T13946 |
prep |
of,loading |
R9064 |
T13948 |
T13949 |
compound |
GST,TACC2 |
R9065 |
T13949 |
T13947 |
pobj |
TACC2,of |
R9066 |
T13950 |
T13949 |
punct |
-,TACC2 |
R9067 |
T13951 |
T13949 |
cc |
and,TACC2 |
R9068 |
T13952 |
T13949 |
conj |
GST,TACC2 |
R9069 |
T13953 |
T13936 |
punct |
.,represent |
R5177 |
T8333 |
T8332 |
prep |
of,Comparison |
R5178 |
T8334 |
T8333 |
pobj |
modeled,of |
R5179 |
T8335 |
T8332 |
prep |
with,Comparison |
R5180 |
T8336 |
T8337 |
advmod |
experimentally,defined |
R5181 |
T8337 |
T8335 |
pobj |
defined,with |
R5182 |
T8338 |
T8332 |
appos |
interactions,Comparison |
R5183 |
T8339 |
T8338 |
prep |
of,interactions |
R5184 |
T8340 |
T8341 |
det |
the,proteins |
R5185 |
T8341 |
T8339 |
pobj |
proteins,of |
R5186 |
T8342 |
T8341 |
compound |
vertebrate,proteins |
R5187 |
T8343 |
T8341 |
compound |
TACC,proteins |
R5188 |
T8345 |
T8346 |
det |
The,data |
R5189 |
T8346 |
T8348 |
nsubj |
data,is |
R5190 |
T8347 |
T8346 |
compound |
interaction,data |
R5191 |
T8348 |
T8353 |
ccomp |
is,beginning |
R5192 |
T8349 |
T8346 |
prep |
for,data |
R5193 |
T8350 |
T8351 |
det |
the,TACCs |
R5194 |
T8351 |
T8349 |
pobj |
TACCs,for |
R5195 |
T8352 |
T8351 |
compound |
vertebrate,TACCs |
R5196 |
T8354 |
T8355 |
advmod |
relatively,limited |
R5197 |
T8355 |
T8348 |
acomp |
limited,is |
R5198 |
T8356 |
T8353 |
punct |
;,beginning |
R5199 |
T8357 |
T8353 |
advmod |
however,beginning |
R5200 |
T8358 |
T8353 |
punct |
", ",beginning |
R5201 |
T8359 |
T8360 |
compound |
interaction,networks |
R5202 |
T8360 |
T8353 |
nsubj |
networks,beginning |
R5203 |
T8361 |
T8353 |
aux |
are,beginning |
R5204 |
T8362 |
T8353 |
advmod |
now,beginning |
R5205 |
T8363 |
T8364 |
aux |
to,emerge |
R5206 |
T8364 |
T8353 |
xcomp |
emerge,beginning |
R5207 |
T8365 |
T8353 |
punct |
.,beginning |
R5208 |
T8367 |
T8368 |
det |
The,results |
R5209 |
T8368 |
T8369 |
nsubj |
results,indicate |
R5210 |
T8370 |
T8368 |
prep |
of,results |
R5211 |
T8371 |
T8372 |
poss |
our,analysis |
R5212 |
T8372 |
T8370 |
pobj |
analysis,of |
R5213 |
T8373 |
T8372 |
amod |
functional,analysis |
R5214 |
T8374 |
T8368 |
punct |
", ",results |
R5215 |
T8375 |
T8376 |
advmod |
as,as |
R5216 |
T8376 |
T8368 |
cc |
as,results |
R5217 |
T8377 |
T8376 |
advmod |
well,as |
R5218 |
T8378 |
T8379 |
amod |
other,data |
R5219 |
T8379 |
T8368 |
conj |
data,results |
R5220 |
T8380 |
T8379 |
amod |
published,data |
R5221 |
T8381 |
T8369 |
advmod |
clearly,indicate |
R5222 |
T8382 |
T8383 |
mark |
that,interact |
R5223 |
T8383 |
T8369 |
ccomp |
interact,indicate |
R5224 |
T8384 |
T8385 |
det |
the,TACCs |
R5225 |
T8385 |
T8383 |
nsubj |
TACCs,interact |
R5226 |
T8386 |
T8385 |
compound |
vertebrate,TACCs |
R5227 |
T8387 |
T8383 |
prep |
with,interact |
R5228 |
T8388 |
T8387 |
pobj |
proteins,with |
R5229 |
T8389 |
T8390 |
dep |
that,divided |
R5230 |
T8390 |
T8388 |
relcl |
divided,proteins |
R5231 |
T8391 |
T8390 |
aux |
can,divided |
R5232 |
T8392 |
T8390 |
auxpass |
be,divided |
R5233 |
T8393 |
T8390 |
prep |
into,divided |
R5234 |
T8394 |
T8395 |
nummod |
two,categories |
R5235 |
T8395 |
T8393 |
pobj |
categories,into |
R5236 |
T8396 |
T8395 |
amod |
broad,categories |
R5237 |
T8397 |
T8369 |
punct |
: ,indicate |
R5238 |
T8398 |
T8399 |
meta |
1,proteins |
R5239 |
T8401 |
T8398 |
punct |
),1 |
R5240 |
T8402 |
T8399 |
prep |
with,proteins |
R5241 |
T8403 |
T8402 |
pobj |
roles,with |
R5242 |
T8404 |
T8403 |
prep |
in,roles |
R5243 |
T8405 |
T8406 |
npadvmod |
centrosome,mitotic |
R5244 |
T8406 |
T8408 |
amod |
mitotic,spindle |
R5245 |
T8407 |
T8406 |
punct |
/,mitotic |
R5246 |
T8408 |
T8409 |
compound |
spindle,dynamics |
R5247 |
T8409 |
T8404 |
pobj |
dynamics,in |
R5248 |
T8410 |
T8399 |
punct |
", ",proteins |
R5249 |
T8411 |
T8399 |
cc |
and,proteins |
R5250 |
T8412 |
T8413 |
meta |
2,proteins |
R5251 |
T8413 |
T8399 |
conj |
proteins,proteins |
R5252 |
T8414 |
T8412 |
punct |
),2 |
R5253 |
T8415 |
T8413 |
acl |
involved,proteins |
R5254 |
T8416 |
T8415 |
prep |
in,involved |
R5255 |
T8417 |
T8418 |
compound |
gene,regulation |
R5256 |
T8418 |
T8416 |
pobj |
regulation,in |
R5257 |
T8419 |
T8415 |
punct |
", ",involved |
R5258 |
T8420 |
T8421 |
preconj |
either,at |
R5259 |
T8421 |
T8415 |
prep |
at,involved |
R5260 |
T8422 |
T8423 |
det |
the,level |
R5261 |
T8423 |
T8421 |
pobj |
level,at |
R5262 |
T8424 |
T8423 |
prep |
of,level |
R5263 |
T8425 |
T8424 |
pobj |
transcription,of |
R5264 |
T8426 |
T8425 |
punct |
", ",transcription |
R5265 |
T8427 |
T8425 |
cc |
or,transcription |
R5266 |
T8428 |
T8429 |
amod |
subsequent,processing |
R5267 |
T8429 |
T8425 |
conj |
processing,transcription |
R5268 |
T8430 |
T8429 |
compound |
RNA,processing |
R5269 |
T8431 |
T8429 |
cc |
and,processing |
R5270 |
T8432 |
T8429 |
conj |
translation,processing |
R5271 |
T8433 |
T8434 |
punct |
[,3 |
R5272 |
T8434 |
T8415 |
parataxis |
3,involved |
R5273 |
T8435 |
T8434 |
punct |
",",3 |
R5274 |
T8436 |
T8434 |
appos |
5,3 |
R5275 |
T8437 |
T8438 |
punct |
-,7 |
R5276 |
T8438 |
T8436 |
prep |
7,5 |
R5277 |
T8439 |
T8434 |
punct |
",",3 |
R5278 |
T8440 |
T8434 |
appos |
15,3 |
R5279 |
T8441 |
T8434 |
punct |
",",3 |
R5280 |
T8442 |
T8434 |
appos |
19,3 |
R5281 |
T8443 |
T8444 |
punct |
-,21 |
R5282 |
T8444 |
T8442 |
prep |
21,19 |
R5283 |
T8445 |
T8434 |
punct |
",",3 |
R5284 |
T8446 |
T8434 |
appos |
24,3 |
R5285 |
T8447 |
T8434 |
punct |
",",3 |
R5286 |
T8448 |
T8434 |
appos |
25,3 |
R5287 |
T8449 |
T8434 |
punct |
",",3 |
R5288 |
T8450 |
T8434 |
appos |
33,3 |
R5289 |
T8451 |
T8434 |
punct |
",",3 |
R5290 |
T8452 |
T8434 |
appos |
34,3 |
R5291 |
T8453 |
T8434 |
punct |
],3 |
R5292 |
T8454 |
T8413 |
punct |
.,proteins |
R5293 |
T8456 |
T8457 |
nsubj |
Many,appear |
R5294 |
T8458 |
T8456 |
prep |
of,Many |
R5295 |
T8459 |
T8460 |
det |
these,proteins |
R5296 |
T8460 |
T8458 |
pobj |
proteins,of |
R5297 |
T8461 |
T8457 |
aux |
do,appear |
R5298 |
T8462 |
T8457 |
neg |
not,appear |
R5299 |
T8463 |
T8464 |
aux |
to,interact |
R5300 |
T8464 |
T8457 |
xcomp |
interact,appear |
R5301 |
T8465 |
T8464 |
advmod |
directly,interact |
R5302 |
T8466 |
T8464 |
prep |
with,interact |
R5303 |
T8467 |
T8468 |
det |
the,TACCs |
R5304 |
T8468 |
T8466 |
pobj |
TACCs,with |
R5305 |
T8469 |
T8468 |
compound |
protostome,TACCs |
R5306 |
T8470 |
T8457 |
punct |
", ",appear |
R5307 |
T8471 |
T8457 |
cc |
but,appear |
R5308 |
T8472 |
T8473 |
aux |
would,expected |
R5309 |
T8473 |
T8457 |
conj |
expected,appear |
R5310 |
T8474 |
T8473 |
auxpass |
be,expected |
R5311 |
T8475 |
T8476 |
aux |
to,be |
R5312 |
T8476 |
T8473 |
xcomp |
be,expected |
R5313 |
T8477 |
T8476 |
prep |
in,be |
R5314 |
T8478 |
T8479 |
det |
the,complex |
R5315 |
T8479 |
T8477 |
pobj |
complex,in |
R5316 |
T8480 |
T8479 |
amod |
same,complex |
R5317 |
T8481 |
T8479 |
compound |
protein,complex |
R5318 |
T8482 |
T8483 |
punct |
(,6D |
R5319 |
T8483 |
T8473 |
parataxis |
6D,expected |
R5320 |
T8484 |
T8483 |
nmod |
Fig.,6D |
R5321 |
T8485 |
T8483 |
nummod |
6C,6D |
R5322 |
T8486 |
T8483 |
punct |
",",6D |
R5323 |
T8487 |
T8483 |
punct |
),6D |
R5324 |
T8488 |
T8457 |
punct |
.,appear |
R5325 |
T8490 |
T8491 |
amod |
Significant,analysis |
R5326 |
T8491 |
T8492 |
nsubjpass |
analysis,published |
R5327 |
T8493 |
T8491 |
prep |
of,analysis |
R5328 |
T8494 |
T8495 |
det |
the,association |
R5329 |
T8495 |
T8493 |
pobj |
association,of |
R5330 |
T8496 |
T8495 |
prep |
of,association |
R5331 |
T8497 |
T8498 |
det |
the,TACCs |
R5332 |
T8498 |
T8496 |
pobj |
TACCs,of |
R5333 |
T8499 |
T8495 |
prep |
with,association |
R5334 |
T8500 |
T8501 |
det |
the,centrosome |
R5335 |
T8501 |
T8499 |
pobj |
centrosome,with |
R5336 |
T8502 |
T8495 |
cc |
and,association |
R5337 |
T8503 |
T8504 |
det |
the,dynamics |
R5338 |
T8504 |
T8495 |
conj |
dynamics,association |
R5339 |
T8505 |
T8504 |
prep |
of,dynamics |
R5340 |
T8506 |
T8507 |
amod |
mitotic,spindle |
R5341 |
T8507 |
T8508 |
compound |
spindle,assembly |
R5342 |
T8508 |
T8505 |
pobj |
assembly,of |
R5343 |
T8509 |
T8491 |
prep |
from,analysis |
R5344 |
T8510 |
T8509 |
pobj |
yeast,from |
R5345 |
T8511 |
T8509 |
prep |
to,from |
R5346 |
T8512 |
T8511 |
pobj |
humans,to |
R5347 |
T8513 |
T8492 |
aux |
has,published |
R5348 |
T8514 |
T8492 |
auxpass |
been,published |
R5349 |
T8515 |
T8516 |
punct |
[,5 |
R5350 |
T8516 |
T8492 |
parataxis |
5,published |
R5351 |
T8517 |
T8516 |
punct |
",",5 |
R5352 |
T8518 |
T8516 |
appos |
6,5 |
R5353 |
T8519 |
T8516 |
punct |
",",5 |
R5354 |
T8520 |
T8516 |
appos |
21,5 |
R5355 |
T8521 |
T8522 |
punct |
-,24 |
R5356 |
T8522 |
T8520 |
prep |
24,21 |
R5357 |
T8523 |
T8516 |
punct |
],5 |
R5358 |
T8524 |
T8492 |
punct |
.,published |
R5359 |
T8526 |
T8527 |
prep |
From,seems |
R5360 |
T8528 |
T8529 |
det |
this,analysis |
R5361 |
T8529 |
T8526 |
pobj |
analysis,From |
R5362 |
T8530 |
T8527 |
punct |
", ",seems |
R5363 |
T8531 |
T8527 |
nsubj |
it,seems |
R5364 |
T8532 |
T8527 |
oprd |
likely,seems |
R5365 |
T8533 |
T8534 |
mark |
that,retained |
R5366 |
T8534 |
T8527 |
ccomp |
retained,seems |
R5367 |
T8535 |
T8536 |
det |
the,protein |
R5368 |
T8536 |
T8534 |
nsubj |
protein,retained |
R5369 |
T8537 |
T8536 |
compound |
vertebrate,protein |
R5370 |
T8538 |
T8536 |
compound |
TACC3,protein |
R5371 |
T8539 |
T8534 |
aux |
has,retained |
R5372 |
T8540 |
T8541 |
det |
this,function |
R5373 |
T8541 |
T8534 |
dobj |
function,retained |
R5374 |
T8542 |
T8541 |
amod |
direct,function |
R5375 |
T8543 |
T8541 |
amod |
ancestral,function |
R5376 |
T8544 |
T8527 |
punct |
", ",seems |
R5377 |
T8545 |
T8527 |
prep |
based,seems |
R5378 |
T8546 |
T8545 |
prep |
upon,based |
R5379 |
T8547 |
T8548 |
poss |
its,location |
R5380 |
T8548 |
T8546 |
pobj |
location,upon |
R5381 |
T8549 |
T8548 |
prep |
in,location |
R5382 |
T8550 |
T8551 |
det |
these,structures |
R5383 |
T8551 |
T8549 |
pobj |
structures,in |
R5384 |
T8552 |
T8548 |
prep |
during,location |
R5385 |
T8553 |
T8552 |
pobj |
mitosis,during |
R5386 |
T8554 |
T8555 |
punct |
[,27 |
R5387 |
T8555 |
T8548 |
parataxis |
27,location |
R5388 |
T8556 |
T8555 |
punct |
],27 |
R5389 |
T8557 |
T8548 |
punct |
", ",location |
R5390 |
T8558 |
T8559 |
poss |
its,interaction |
R5391 |
T8559 |
T8548 |
conj |
interaction,location |
R5392 |
T8560 |
T8559 |
amod |
strong,interaction |
R5393 |
T8561 |
T8559 |
prep |
with,interaction |
R5394 |
T8562 |
T8563 |
compound |
Aurora,A |
R5395 |
T8563 |
T8561 |
pobj |
A,with |
R5396 |
T8564 |
T8563 |
compound |
Kinase,A |
R5397 |
T8565 |
T8559 |
punct |
", ",interaction |
R5398 |
T8566 |
T8559 |
cc |
and,interaction |
R5399 |
T8567 |
T8568 |
det |
the,observation |
R5400 |
T8568 |
T8559 |
conj |
observation,interaction |
R5401 |
T8569 |
T8570 |
mark |
that,is |
R5402 |
T8570 |
T8568 |
acl |
is,observation |
R5403 |
T8571 |
T8570 |
nsubj |
it,is |
R5404 |
T8572 |
T8573 |
det |
the,protein |
R5405 |
T8573 |
T8570 |
attr |
protein,is |
R5406 |
T8574 |
T8573 |
advmod |
only,protein |
R5407 |
T8575 |
T8573 |
amod |
human,protein |
R5408 |
T8576 |
T8573 |
compound |
TACC,protein |
R5409 |
T8577 |
T8573 |
acl |
phosphorylated,protein |
R5410 |
T8578 |
T8577 |
agent |
by,phosphorylated |
R5411 |
T8579 |
T8580 |
det |
this,enzyme |
R5412 |
T8580 |
T8578 |
pobj |
enzyme,by |
R5413 |
T8581 |
T8582 |
punct |
[,21 |
R5414 |
T8582 |
T8568 |
parataxis |
21,observation |
R5415 |
T8583 |
T8582 |
punct |
],21 |
R5416 |
T8584 |
T8527 |
punct |
.,seems |
R5417 |
T8586 |
T8587 |
advmod |
However,suggests |
R5418 |
T8588 |
T8587 |
punct |
", ",suggests |
R5419 |
T8589 |
T8590 |
det |
the,variability |
R5420 |
T8590 |
T8587 |
nsubj |
variability,suggests |
R5421 |
T8591 |
T8590 |
prep |
of,variability |
R5422 |
T8592 |
T8593 |
det |
the,domain |
R5423 |
T8593 |
T8591 |
pobj |
domain,of |
R5424 |
T8594 |
T8593 |
amod |
central,domain |
R5425 |
T8595 |
T8593 |
prep |
of,domain |
R5426 |
T8596 |
T8597 |
det |
the,orthologues |
R5427 |
T8597 |
T8595 |
pobj |
orthologues,of |
R5428 |
T8598 |
T8597 |
compound |
vertebrate,orthologues |
R5429 |
T8599 |
T8587 |
punct |
", ",suggests |
R5430 |
T8600 |
T8601 |
mark |
that,acquired |
R5431 |
T8601 |
T8587 |
ccomp |
acquired,suggests |
R5432 |
T8602 |
T8601 |
nsubj |
TACC3,acquired |
R5433 |
T8603 |
T8601 |
aux |
may,acquired |
R5434 |
T8604 |
T8601 |
advmod |
also,acquired |
R5435 |
T8605 |
T8601 |
aux |
have,acquired |
R5436 |
T8606 |
T8607 |
amod |
additional,functions |
R5437 |
T8607 |
T8601 |
dobj |
functions,acquired |
R5438 |
T8608 |
T8606 |
punct |
", ",additional |
R5439 |
T8609 |
T8606 |
cc |
and,additional |
R5440 |
T8610 |
T8611 |
prep |
in,specific |
R5441 |
T8611 |
T8606 |
conj |
specific,additional |
R5442 |
T8612 |
T8613 |
det |
some,instances |
R5443 |
T8613 |
T8610 |
pobj |
instances,in |
R5444 |
T8614 |
T8611 |
punct |
", ",specific |
R5445 |
T8615 |
T8611 |
npadvmod |
species,specific |
R5446 |
T8616 |
T8611 |
punct |
-,specific |
R5447 |
T8617 |
T8587 |
punct |
.,suggests |
R5448 |
T8619 |
T8620 |
prep |
For,acquired |
R5449 |
T8621 |
T8619 |
pobj |
instance,For |
R5450 |
T8622 |
T8620 |
punct |
", ",acquired |
R5451 |
T8623 |
T8620 |
prep |
in,acquired |
R5452 |
T8624 |
T8625 |
compound |
X.,laevis |
R5453 |
T8625 |
T8623 |
pobj |
laevis,in |
R5454 |
T8626 |
T8620 |
punct |
", ",acquired |
R5455 |
T8627 |
T8628 |
det |
the,protein |
R5456 |
T8628 |
T8620 |
nsubj |
protein,acquired |
R5457 |
T8629 |
T8628 |
compound |
maskin,protein |
R5458 |
T8630 |
T8620 |
aux |
has,acquired |
R5459 |
T8631 |
T8632 |
det |
a,site |
R5460 |
T8632 |
T8620 |
dobj |
site,acquired |
R5461 |
T8633 |
T8632 |
compound |
binding,site |
R5462 |
T8634 |
T8632 |
prep |
for,site |
R5463 |
T8635 |
T8636 |
det |
the,protein |
R5464 |
T8636 |
T8634 |
pobj |
protein,for |
R5465 |
T8637 |
T8636 |
compound |
eIF4E,protein |
R5466 |
T8638 |
T8632 |
punct |
", ",site |
R5467 |
T8639 |
T8632 |
cc |
and,site |
R5468 |
T8640 |
T8641 |
advmod |
thus,function |
R5469 |
T8641 |
T8632 |
conj |
function,site |
R5470 |
T8642 |
T8641 |
det |
a,function |
R5471 |
T8643 |
T8641 |
prep |
in,function |
R5472 |
T8644 |
T8645 |
det |
the,control |
R5473 |
T8645 |
T8643 |
pobj |
control,in |
R5474 |
T8646 |
T8645 |
amod |
coordinated,control |
R5475 |
T8647 |
T8645 |
prep |
of,control |
R5476 |
T8648 |
T8647 |
pobj |
polyadenylation,of |
R5477 |
T8649 |
T8648 |
cc |
and,polyadenylation |
R5478 |
T8650 |
T8648 |
conj |
translation,polyadenylation |
R5479 |
T8651 |
T8641 |
prep |
in,function |
R5480 |
T8652 |
T8653 |
det |
the,oocyte |
R5481 |
T8653 |
T8651 |
pobj |
oocyte,in |
R5482 |
T8654 |
T8653 |
compound |
Xenopus,oocyte |
R5483 |
T8655 |
T8656 |
punct |
[,35 |
R5484 |
T8656 |
T8620 |
parataxis |
35,acquired |
R5485 |
T8657 |
T8656 |
nummod |
8,35 |
R5486 |
T8658 |
T8656 |
punct |
",",35 |
R5487 |
T8659 |
T8656 |
punct |
],35 |
R5488 |
T8660 |
T8620 |
punct |
.,acquired |
R5489 |
T8662 |
T8663 |
det |
A,study |
R5490 |
T8663 |
T8665 |
nsubj |
study,suggested |
R5491 |
T8664 |
T8663 |
amod |
recent,study |
R5492 |
T8665 |
T8667 |
ccomp |
suggested,is |
R5493 |
T8666 |
T8665 |
aux |
has,suggested |
R5494 |
T8668 |
T8669 |
mark |
that,be |
R5495 |
T8669 |
T8665 |
ccomp |
be,suggested |
R5496 |
T8670 |
T8671 |
det |
this,function |
R5497 |
T8671 |
T8669 |
nsubj |
function,be |
R5498 |
T8672 |
T8669 |
aux |
may,be |
R5499 |
T8673 |
T8669 |
acomp |
unique,be |
R5500 |
T8674 |
T8673 |
prep |
to,unique |
R5501 |
T8675 |
T8674 |
pobj |
maskin,to |
R5502 |
T8676 |
T8667 |
punct |
: ,is |
R5503 |
T8677 |
T8678 |
mark |
although,is |
R5504 |
T8678 |
T8667 |
advcl |
is,is |
R5505 |
T8679 |
T8678 |
nsubj |
it,is |
R5506 |
T8680 |
T8678 |
acomp |
unclear,is |
R5507 |
T8681 |
T8682 |
mark |
whether,interact |
R5508 |
T8682 |
T8678 |
ccomp |
interact,is |
R5509 |
T8683 |
T8684 |
det |
the,proteins |
R5510 |
T8684 |
T8682 |
nsubj |
proteins,interact |
R5511 |
T8685 |
T8684 |
amod |
other,proteins |
R5512 |
T8686 |
T8684 |
compound |
vertebrate,proteins |
R5513 |
T8687 |
T8684 |
compound |
TACC3,proteins |
R5514 |
T8688 |
T8682 |
prep |
with,interact |
R5515 |
T8689 |
T8690 |
det |
the,complex |
R5516 |
T8690 |
T8688 |
pobj |
complex,with |
R5517 |
T8691 |
T8692 |
compound |
eIF4E,CPEB |
R5518 |
T8692 |
T8690 |
compound |
CPEB,complex |
R5519 |
T8693 |
T8692 |
punct |
/,CPEB |
R5520 |
T8694 |
T8667 |
punct |
", ",is |
R5521 |
T8695 |
T8696 |
det |
the,isoform |
R5522 |
T8696 |
T8667 |
nsubj |
isoform,is |
R5523 |
T8697 |
T8696 |
amod |
human,isoform |
R5524 |
T8698 |
T8696 |
compound |
TACC1A,isoform |
R5525 |
T8699 |
T8667 |
acomp |
unable,is |
R5526 |
T8700 |
T8701 |
aux |
to,interact |
R5527 |
T8701 |
T8699 |
xcomp |
interact,unable |
R5528 |
T8702 |
T8701 |
prep |
with,interact |
R5529 |
T8703 |
T8704 |
det |
the,complex |
R5530 |
T8704 |
T8702 |
pobj |
complex,with |
R5531 |
T8705 |
T8706 |
compound |
eIF4E,CPEB |
R5532 |
T8706 |
T8704 |
compound |
CPEB,complex |
R5533 |
T8707 |
T8706 |
punct |
/,CPEB |
R5534 |
T8708 |
T8667 |
punct |
.,is |
R5535 |
T8710 |
T8711 |
advmod |
Instead,evolved |
R5536 |
T8712 |
T8711 |
punct |
", ",evolved |
R5537 |
T8713 |
T8714 |
det |
some,isoforms |
R5538 |
T8714 |
T8711 |
nsubj |
isoforms,evolved |
R5539 |
T8715 |
T8714 |
compound |
TACC1,isoforms |
R5540 |
T8716 |
T8711 |
aux |
have,evolved |
R5541 |
T8717 |
T8718 |
det |
a,function |
R5542 |
T8718 |
T8711 |
dobj |
function,evolved |
R5543 |
T8719 |
T8718 |
amod |
related,function |
R5544 |
T8720 |
T8719 |
punct |
", ",related |
R5545 |
T8721 |
T8719 |
cc |
but,related |
R5546 |
T8722 |
T8719 |
conj |
distinct,related |
R5547 |
T8723 |
T8711 |
prep |
by,evolved |
R5548 |
T8724 |
T8725 |
advmod |
directly,interacting |
R5549 |
T8725 |
T8723 |
pcomp |
interacting,by |
R5550 |
T8726 |
T8725 |
prep |
with,interacting |
R5551 |
T8727 |
T8726 |
pobj |
elements,with |
R5552 |
T8728 |
T8727 |
prep |
of,elements |
R5553 |
T8729 |
T8730 |
det |
the,machinery |
R5554 |
T8730 |
T8728 |
pobj |
machinery,of |
R5555 |
T8731 |
T8732 |
nmod |
RNA,splicing |
R5556 |
T8732 |
T8730 |
nmod |
splicing,machinery |
R5557 |
T8733 |
T8732 |
cc |
and,splicing |
R5558 |
T8734 |
T8732 |
conj |
transport,splicing |
R5559 |
T8735 |
T8736 |
punct |
[,19 |
R5560 |
T8736 |
T8711 |
parataxis |
19,evolved |
R5561 |
T8737 |
T8736 |
punct |
],19 |
R5562 |
T8738 |
T8711 |
punct |
.,evolved |
R5563 |
T8740 |
T8741 |
aux |
To,characterize |
R5564 |
T8741 |
T8743 |
advcl |
characterize,used |
R5565 |
T8742 |
T8741 |
advmod |
further,characterize |
R5566 |
T8744 |
T8745 |
det |
the,functions |
R5567 |
T8745 |
T8741 |
dobj |
functions,characterize |
R5568 |
T8746 |
T8745 |
amod |
evolving,functions |
R5569 |
T8747 |
T8745 |
prep |
of,functions |
R5570 |
T8748 |
T8749 |
det |
the,proteins |
R5571 |
T8749 |
T8747 |
pobj |
proteins,of |
R5572 |
T8750 |
T8749 |
compound |
TACC,proteins |
R5573 |
T8751 |
T8743 |
punct |
", ",used |
R5574 |
T8752 |
T8743 |
nsubj |
we,used |
R5575 |
T8753 |
T8743 |
aux |
have,used |
R5576 |
T8754 |
T8755 |
det |
an,method |
R5577 |
T8755 |
T8743 |
dobj |
method,used |
R5578 |
T8756 |
T8755 |
amod |
unbiased,method |
R5579 |
T8757 |
T8755 |
nmod |
yeast,method |
R5580 |
T8758 |
T8759 |
nummod |
two,hybrid |
R5581 |
T8759 |
T8755 |
compound |
hybrid,method |
R5582 |
T8760 |
T8755 |
compound |
screening,method |
R5583 |
T8761 |
T8762 |
aux |
to,identify |
R5584 |
T8762 |
T8743 |
advcl |
identify,used |
R5585 |
T8763 |
T8762 |
dobj |
proteins,identify |
R5586 |
T8764 |
T8765 |
dep |
that,bind |
R5587 |
T8765 |
T8763 |
relcl |
bind,proteins |
R5588 |
T8766 |
T8765 |
prep |
to,bind |
R5589 |
T8767 |
T8768 |
det |
the,proteins |
R5590 |
T8768 |
T8766 |
pobj |
proteins,to |
R5591 |
T8769 |
T8768 |
amod |
human,proteins |
R5592 |
T8770 |
T8768 |
compound |
TACC,proteins |
R5593 |
T8771 |
T8772 |
punct |
[,34 |
R5594 |
T8772 |
T8743 |
parataxis |
34,used |
R5595 |
T8773 |
T8772 |
nummod |
3,34 |
R5596 |
T8774 |
T8772 |
punct |
",",34 |
R5597 |
T8775 |
T8772 |
punct |
],34 |
R5598 |
T8776 |
T8743 |
punct |
.,used |
R5599 |
T8778 |
T8779 |
prep |
In,identified |
R5600 |
T8780 |
T8781 |
det |
a,screen |
R5601 |
T8781 |
T8778 |
pobj |
screen,In |
R5602 |
T8782 |
T8781 |
prep |
of,screen |
R5603 |
T8783 |
T8784 |
det |
a,library |
R5604 |
T8784 |
T8782 |
pobj |
library,of |
R5605 |
T8785 |
T8784 |
nmod |
MATCHMAKER,library |
R5606 |
T8786 |
T8787 |
amod |
fetal,brain |
R5607 |
T8787 |
T8784 |
compound |
brain,library |
R5608 |
T8788 |
T8789 |
punct |
(,Clontech |
R5609 |
T8789 |
T8784 |
parataxis |
Clontech,library |
R5610 |
T8790 |
T8789 |
compound |
BD,Clontech |
R5611 |
T8791 |
T8789 |
compound |
Biosciences,Clontech |
R5612 |
T8792 |
T8789 |
punct |
),Clontech |
R5613 |
T8793 |
T8779 |
punct |
", ",identified |
R5614 |
T8794 |
T8779 |
prep |
in,identified |
R5615 |
T8795 |
T8794 |
pobj |
addition,in |
R5616 |
T8796 |
T8795 |
prep |
to,addition |
R5617 |
T8797 |
T8796 |
pcomp |
isolating,to |
R5618 |
T8798 |
T8799 |
det |
the,acetyltransferase |
R5619 |
T8799 |
T8797 |
dobj |
acetyltransferase,isolating |
R5620 |
T8800 |
T8799 |
compound |
histone,acetyltransferase |
R5621 |
T8801 |
T8799 |
appos |
hGCN5L2,acetyltransferase |
R5622 |
T8802 |
T8803 |
punct |
[,34 |
R5623 |
T8803 |
T8797 |
parataxis |
34,isolating |
R5624 |
T8804 |
T8803 |
punct |
],34 |
R5625 |
T8805 |
T8779 |
punct |
", ",identified |
R5626 |
T8806 |
T8779 |
nsubj |
we,identified |
R5627 |
T8807 |
T8779 |
advmod |
also,identified |
R5628 |
T8808 |
T8809 |
det |
the,isoform |
R5629 |
T8809 |
T8779 |
dobj |
isoform,identified |
R5630 |
T8810 |
T8809 |
compound |
β3,isoform |
R5631 |
T8811 |
T8809 |
prep |
of,isoform |
R5632 |
T8812 |
T8813 |
compound |
retinoid,X |
R5633 |
T8813 |
T8815 |
compound |
X,β |
R5634 |
T8814 |
T8813 |
punct |
-,X |
R5635 |
T8815 |
T8811 |
pobj |
β,of |
R5636 |
T8816 |
T8815 |
compound |
receptor,β |
R5637 |
T8817 |
T8779 |
prep |
as,identified |
R5638 |
T8818 |
T8819 |
det |
a,protein |
R5639 |
T8819 |
T8817 |
pobj |
protein,as |
R5640 |
T8820 |
T8821 |
dep |
that,interacts |
R5641 |
T8821 |
T8819 |
relcl |
interacts,protein |
R5642 |
T8822 |
T8821 |
prep |
with,interacts |
R5643 |
T8823 |
T8824 |
det |
the,domain |
R5644 |
T8824 |
T8822 |
pobj |
domain,with |
R5645 |
T8825 |
T8824 |
compound |
TACC,domain |
R5646 |
T8826 |
T8824 |
prep |
of,domain |
R5647 |
T8827 |
T8826 |
pobj |
TACC2,of |
R5648 |
T8828 |
T8779 |
punct |
.,identified |
R5649 |
T8830 |
T8831 |
mark |
As,shown |
R5650 |
T8831 |
T8832 |
advcl |
shown,confirmed |
R5651 |
T8833 |
T8831 |
prep |
in,shown |
R5652 |
T8834 |
T8833 |
pobj |
Fig.,in |
R5653 |
T8835 |
T8834 |
nummod |
7,Fig. |
R5654 |
T8836 |
T8832 |
punct |
", ",confirmed |
R5655 |
T8837 |
T8838 |
det |
this,interaction |
R5656 |
T8838 |
T8832 |
nsubjpass |
interaction,confirmed |
R5657 |
T8839 |
T8832 |
auxpass |
is,confirmed |
R5658 |
T8840 |
T8841 |
advmod |
in,vitro |
R5659 |
T8841 |
T8832 |
advmod |
vitro,confirmed |
R5660 |
T8842 |
T8832 |
prep |
by,confirmed |
R5661 |
T8843 |
T8844 |
npadvmod |
GST,pull |
R5662 |
T8844 |
T8846 |
amod |
pull,analysis |
R5663 |
T8845 |
T8844 |
punct |
-,pull |
R5664 |
T8846 |
T8842 |
pobj |
analysis,by |
R5665 |
T8847 |
T8844 |
prt |
down,pull |
R5666 |
T8848 |
T8832 |
punct |
.,confirmed |
R5667 |
T8850 |
T8851 |
advmod |
Significantly,is |
R5668 |
T8852 |
T8851 |
punct |
", ",is |
R5669 |
T8853 |
T8851 |
nsubj |
RXRβ,is |
R5670 |
T8854 |
T8855 |
det |
a,family |
R5671 |
T8855 |
T8851 |
attr |
family,is |
R5672 |
T8856 |
T8855 |
amod |
close,family |
R5673 |
T8857 |
T8855 |
amod |
relative,family |
R5674 |
T8858 |
T8855 |
prep |
of,family |
R5675 |
T8859 |
T8860 |
det |
the,receptor |
R5676 |
T8860 |
T8858 |
pobj |
receptor,of |
R5677 |
T8861 |
T8860 |
amod |
nuclear,receptor |
R5678 |
T8862 |
T8860 |
compound |
hormone,receptor |
R5679 |
T8863 |
T8860 |
punct |
", ",receptor |
R5680 |
T8864 |
T8860 |
appos |
nhr,receptor |
R5681 |
T8865 |
T8864 |
punct |
-,nhr |
R5682 |
T8866 |
T8864 |
nummod |
86,nhr |
R5683 |
T8867 |
T8860 |
punct |
", ",receptor |
R5684 |
T8868 |
T8860 |
prep |
from,receptor |
R5685 |
T8869 |
T8870 |
compound |
C.,elegans |
R5686 |
T8870 |
T8868 |
pobj |
elegans,from |
R5687 |
T8871 |
T8870 |
punct |
", ",elegans |
R5688 |
T8872 |
T8873 |
dep |
which,interacts |
R5689 |
T8873 |
T8870 |
relcl |
interacts,elegans |
R5690 |
T8874 |
T8873 |
prep |
with,interacts |
R5691 |
T8875 |
T8876 |
det |
the,protein |
R5692 |
T8876 |
T8874 |
pobj |
protein,with |
R5693 |
T8877 |
T8876 |
compound |
ceTAC,protein |
R5694 |
T8878 |
T8876 |
compound |
binding,protein |
R5695 |
T8879 |
T8876 |
appos |
lin36,protein |
R5696 |
T8880 |
T8881 |
punct |
(,Fig. |
R5697 |
T8881 |
T8873 |
parataxis |
Fig.,interacts |
R5698 |
T8882 |
T8881 |
nummod |
6A,Fig. |
R5699 |
T8883 |
T8881 |
punct |
),Fig. |
R5700 |
T8884 |
T8851 |
punct |
.,is |
R5701 |
T8886 |
T8887 |
nsubj |
This,suggests |
R5702 |
T8888 |
T8889 |
mark |
that,evolved |
R5703 |
T8889 |
T8887 |
ccomp |
evolved,suggests |
R5704 |
T8890 |
T8891 |
mark |
while,require |
R5705 |
T8891 |
T8889 |
advcl |
require,evolved |
R5706 |
T8892 |
T8893 |
compound |
protostome,TACCs |
R5707 |
T8893 |
T8891 |
nsubj |
TACCs,require |
R5708 |
T8894 |
T8891 |
aux |
may,require |
R5709 |
T8895 |
T8896 |
amod |
additional,factors |
R5710 |
T8896 |
T8891 |
dobj |
factors,require |
R5711 |
T8897 |
T8896 |
compound |
protein,factors |
R5712 |
T8898 |
T8899 |
aux |
to,interact |
R5713 |
T8899 |
T8891 |
advcl |
interact,require |
R5714 |
T8900 |
T8899 |
prep |
with,interact |
R5715 |
T8901 |
T8902 |
amod |
such,components |
R5716 |
T8902 |
T8900 |
pobj |
components,with |
R5717 |
T8903 |
T8889 |
punct |
", ",evolved |
R5718 |
T8904 |
T8905 |
det |
the,TACCs |
R5719 |
T8905 |
T8889 |
nsubj |
TACCs,evolved |
R5720 |
T8906 |
T8905 |
prep |
in,TACCs |
R5721 |
T8907 |
T8908 |
amod |
higher,organisms |
R5722 |
T8908 |
T8906 |
pobj |
organisms,in |
R5723 |
T8909 |
T8889 |
aux |
may,evolved |
R5724 |
T8910 |
T8889 |
aux |
have,evolved |
R5725 |
T8911 |
T8912 |
det |
the,ability |
R5726 |
T8912 |
T8889 |
dobj |
ability,evolved |
R5727 |
T8913 |
T8914 |
aux |
to,interact |
R5728 |
T8914 |
T8912 |
acl |
interact,ability |
R5729 |
T8915 |
T8914 |
advmod |
directly,interact |
R5730 |
T8916 |
T8914 |
prep |
with,interact |
R5731 |
T8917 |
T8916 |
pobj |
some,with |
R5732 |
T8918 |
T8917 |
prep |
of,some |
R5733 |
T8919 |
T8920 |
det |
the,proteins |
R5734 |
T8920 |
T8918 |
pobj |
proteins,of |
R5735 |
T8921 |
T8914 |
prep |
in,interact |
R5736 |
T8922 |
T8923 |
det |
the,map |
R5737 |
T8923 |
T8921 |
pobj |
map,in |
R5738 |
T8924 |
T8923 |
amod |
predicted,map |
R5739 |
T8925 |
T8923 |
compound |
interaction,map |
R5740 |
T8926 |
T8927 |
punct |
(,Fig. |
R5741 |
T8927 |
T8887 |
parataxis |
Fig.,suggests |
R5742 |
T8928 |
T8927 |
nummod |
6E,Fig. |
R5743 |
T8929 |
T8927 |
punct |
),Fig. |
R5744 |
T8930 |
T8887 |
punct |
.,suggests |
R5745 |
T8932 |
T8933 |
advmod |
Indeed,appears |
R5746 |
T8934 |
T8933 |
punct |
", ",appears |
R5747 |
T8935 |
T8933 |
nsubj |
this,appears |
R5748 |
T8936 |
T8937 |
aux |
to,linked |
R5749 |
T8937 |
T8933 |
xcomp |
linked,appears |
R5750 |
T8938 |
T8937 |
auxpass |
be,linked |
R5751 |
T8939 |
T8937 |
advmod |
directly,linked |
R5752 |
T8940 |
T8937 |
prep |
to,linked |
R5753 |
T8941 |
T8942 |
det |
the,acquisition |
R5754 |
T8942 |
T8940 |
pobj |
acquisition,to |
R5755 |
T8943 |
T8942 |
prep |
of,acquisition |
R5756 |
T8944 |
T8945 |
amod |
new,domains |
R5757 |
T8945 |
T8943 |
pobj |
domains,of |
R5758 |
T8946 |
T8942 |
cc |
and,acquisition |
R5759 |
T8947 |
T8942 |
conj |
duplication,acquisition |
R5760 |
T8948 |
T8947 |
prep |
of,duplication |
R5761 |
T8949 |
T8950 |
det |
the,precursor |
R5762 |
T8950 |
T8948 |
pobj |
precursor,of |
R5763 |
T8951 |
T8950 |
compound |
chordate,precursor |
R5764 |
T8952 |
T8950 |
compound |
TACC,precursor |
R5765 |
T8953 |
T8933 |
punct |
.,appears |
R5766 |
T8955 |
T8956 |
prep |
In,was |
R5767 |
T8957 |
T8955 |
pobj |
fact,In |
R5768 |
T8958 |
T8956 |
punct |
", ",was |
R5769 |
T8959 |
T8960 |
det |
the,function |
R5770 |
T8960 |
T8956 |
nsubj |
function,was |
R5771 |
T8961 |
T8960 |
amod |
first,function |
R5772 |
T8962 |
T8960 |
amod |
identified,function |
R5773 |
T8963 |
T8960 |
prep |
of,function |
R5774 |
T8964 |
T8965 |
det |
a,protein |
R5775 |
T8965 |
T8963 |
pobj |
protein,of |
R5776 |
T8966 |
T8965 |
compound |
vertebrate,protein |
R5777 |
T8967 |
T8965 |
compound |
TACC,protein |
R5778 |
T8968 |
T8956 |
prep |
as,was |
R5779 |
T8969 |
T8970 |
det |
a,coactivator |
R5780 |
T8970 |
T8968 |
pobj |
coactivator,as |
R5781 |
T8971 |
T8970 |
amod |
transcriptional,coactivator |
R5782 |
T8972 |
T8970 |
acl |
acting,coactivator |
R5783 |
T8973 |
T8972 |
prep |
through,acting |
R5784 |
T8974 |
T8975 |
det |
a,interaction |
R5785 |
T8975 |
T8973 |
pobj |
interaction,through |
R5786 |
T8976 |
T8975 |
amod |
direct,interaction |
R5787 |
T8977 |
T8975 |
prep |
with,interaction |
R5788 |
T8978 |
T8979 |
det |
the,factor |
R5789 |
T8979 |
T8977 |
pobj |
factor,with |
R5790 |
T8980 |
T8979 |
compound |
ARNT,factor |
R5791 |
T8981 |
T8979 |
compound |
transcription,factor |
R5792 |
T8982 |
T8983 |
punct |
[,7 |
R5793 |
T8983 |
T8956 |
parataxis |
7,was |
R5794 |
T8984 |
T8983 |
punct |
],7 |
R5795 |
T8985 |
T8956 |
punct |
.,was |
R5796 |
T8987 |
T8988 |
nsubj |
It,is |
R5797 |
T8989 |
T8988 |
advmod |
also,is |
R5798 |
T8990 |
T8988 |
acomp |
intriguing,is |
R5799 |
T8991 |
T8992 |
mark |
that,interacts |
R5800 |
T8992 |
T8988 |
ccomp |
interacts,is |
R5801 |
T8993 |
T8994 |
det |
the,repeat |
R5802 |
T8994 |
T8992 |
nsubj |
repeat,interacts |
R5803 |
T8995 |
T8996 |
npadvmod |
deuterostome,specific |
R5804 |
T8996 |
T8994 |
amod |
specific,repeat |
R5805 |
T8997 |
T8994 |
compound |
SDP,repeat |
R5806 |
T8998 |
T8992 |
prep |
with,interacts |
R5807 |
T8999 |
T8998 |
pobj |
GAS41,with |
R5808 |
T9000 |
T8999 |
punct |
", ",GAS41 |
R5809 |
T9001 |
T9002 |
det |
a,factor |
R5810 |
T9002 |
T8999 |
appos |
factor,GAS41 |
R5811 |
T9003 |
T9004 |
compound |
component,accessory |
R5812 |
T9004 |
T9002 |
compound |
accessory,factor |
R5813 |
T9005 |
T9004 |
punct |
/,accessory |
R5814 |
T9006 |
T9002 |
prep |
of,factor |
R5815 |
T9007 |
T9008 |
det |
the,complex |
R5816 |
T9008 |
T9006 |
pobj |
complex,of |
R5817 |
T9009 |
T9008 |
amod |
human,complex |
R5818 |
T9010 |
T9011 |
compound |
SWI,SNF |
R5819 |
T9011 |
T9008 |
compound |
SNF,complex |
R5820 |
T9012 |
T9011 |
punct |
/,SNF |
R5821 |
T9013 |
T9014 |
compound |
chromatin,remodeling |
R5822 |
T9014 |
T9008 |
compound |
remodeling,complex |
R5823 |
T9015 |
T9016 |
punct |
[,15 |
R5824 |
T9016 |
T8988 |
parataxis |
15,is |
R5825 |
T9017 |
T9016 |
nummod |
3,15 |
R5826 |
T9018 |
T9016 |
punct |
",",15 |
R5827 |
T9019 |
T9016 |
punct |
],15 |
R5828 |
T9020 |
T8988 |
punct |
.,is |
R5829 |
T9022 |
T9023 |
mark |
Although,is |
R5830 |
T9023 |
T9025 |
advcl |
is,indicate |
R5831 |
T9024 |
T9023 |
expl |
there,is |
R5832 |
T9026 |
T9027 |
det |
a,homologue |
R5833 |
T9027 |
T9023 |
attr |
homologue,is |
R5834 |
T9028 |
T9029 |
compound |
D.,melanogaster |
R5835 |
T9029 |
T9027 |
compound |
melanogaster,homologue |
R5836 |
T9030 |
T9027 |
prep |
of,homologue |
R5837 |
T9031 |
T9030 |
pobj |
GAS41,of |
R5838 |
T9032 |
T9027 |
punct |
", ",homologue |
R5839 |
T9033 |
T9027 |
appos |
dmGAS41,homologue |
R5840 |
T9034 |
T9025 |
punct |
", ",indicate |
R5841 |
T9035 |
T9036 |
det |
the,database |
R5842 |
T9036 |
T9025 |
nsubj |
database,indicate |
R5843 |
T9037 |
T9038 |
amod |
large,scale |
R5844 |
T9038 |
T9039 |
nmod |
scale,interaction |
R5845 |
T9039 |
T9036 |
compound |
interaction,database |
R5846 |
T9040 |
T9039 |
amod |
proteomic,interaction |
R5847 |
T9041 |
T9025 |
aux |
does,indicate |
R5848 |
T9042 |
T9025 |
neg |
not,indicate |
R5849 |
T9043 |
T9044 |
det |
a,interaction |
R5850 |
T9044 |
T9025 |
dobj |
interaction,indicate |
R5851 |
T9045 |
T9044 |
amod |
direct,interaction |
R5852 |
T9046 |
T9044 |
prep |
of,interaction |
R5853 |
T9047 |
T9046 |
pobj |
dmGAS41,of |
R5854 |
T9048 |
T9044 |
prep |
with,interaction |
R5855 |
T9049 |
T9048 |
pobj |
DTACC,with |
R5856 |
T9050 |
T9025 |
punct |
.,indicate |
R5857 |
T9052 |
T9053 |
nsubj |
This,be |
R5858 |
T9054 |
T9053 |
aux |
may,be |
R5859 |
T9055 |
T9053 |
prep |
due,be |
R5860 |
T9056 |
T9055 |
pcomp |
to,due |
R5861 |
T9057 |
T9058 |
det |
the,lack |
R5862 |
T9058 |
T9055 |
pobj |
lack,due |
R5863 |
T9059 |
T9058 |
prep |
of,lack |
R5864 |
T9060 |
T9061 |
det |
the,region |
R5865 |
T9061 |
T9059 |
pobj |
region,of |
R5866 |
T9062 |
T9063 |
compound |
SDP,repeat |
R5867 |
T9063 |
T9061 |
compound |
repeat,region |
R5868 |
T9064 |
T9058 |
prep |
in,lack |
R5869 |
T9065 |
T9066 |
det |
the,protein |
R5870 |
T9066 |
T9064 |
pobj |
protein,in |
R5871 |
T9067 |
T9066 |
compound |
Drosophila,protein |
R5872 |
T9068 |
T9066 |
compound |
TACC,protein |
R5873 |
T9069 |
T9053 |
punct |
.,be |
R5874 |
T9071 |
T9072 |
nsubj |
This,suggests |
R5875 |
T9073 |
T9072 |
advmod |
further,suggests |
R5876 |
T9074 |
T9075 |
mark |
that,gained |
R5877 |
T9075 |
T9072 |
advcl |
gained,suggests |
R5878 |
T9076 |
T9077 |
det |
the,TACCs |
R5879 |
T9077 |
T9075 |
nsubj |
TACCs,gained |
R5880 |
T9078 |
T9077 |
compound |
vertebrate,TACCs |
R5881 |
T9079 |
T9075 |
aux |
have,gained |
R5882 |
T9080 |
T9081 |
det |
the,ability |
R5883 |
T9081 |
T9075 |
dobj |
ability,gained |
R5884 |
T9082 |
T9081 |
amod |
specific,ability |
R5885 |
T9083 |
T9084 |
aux |
to,interact |
R5886 |
T9084 |
T9081 |
acl |
interact,ability |
R5887 |
T9085 |
T9084 |
amod |
direct,interact |
R5888 |
T9086 |
T9084 |
prep |
with,interact |
R5889 |
T9087 |
T9088 |
amod |
transcriptional,complexes |
R5890 |
T9088 |
T9086 |
pobj |
complexes,with |
R5891 |
T9089 |
T9088 |
amod |
regulatory,complexes |
R5892 |
T9090 |
T9075 |
punct |
", ",gained |
R5893 |
T9091 |
T9075 |
cc |
and,gained |
R5894 |
T9092 |
T9093 |
mark |
that,required |
R5895 |
T9093 |
T9075 |
conj |
required,gained |
R5896 |
T9094 |
T9095 |
amod |
bridging,protein |
R5897 |
T9095 |
T9093 |
nsubjpass |
protein,required |
R5898 |
T9096 |
T9095 |
punct |
(,protein |
R5899 |
T9097 |
T9095 |
nmod |
s,protein |
R5900 |
T9098 |
T9095 |
punct |
),protein |
R5901 |
T9099 |
T9093 |
auxpass |
are,required |
R5902 |
T9100 |
T9101 |
neg |
no,longer |
R5903 |
T9101 |
T9093 |
advmod |
longer,required |
R5904 |
T9102 |
T9072 |
punct |
.,suggests |
R5905 |
T9104 |
T9105 |
advmod |
Thus,integrated |
R5906 |
T9106 |
T9105 |
punct |
", ",integrated |
R5907 |
T9107 |
T9108 |
advmod |
where,composed |
R5908 |
T9108 |
T9105 |
advcl |
composed,integrated |
R5909 |
T9109 |
T9110 |
det |
the,protein |
R5910 |
T9110 |
T9108 |
nsubjpass |
protein,composed |
R5911 |
T9111 |
T9110 |
compound |
ceTAC,protein |
R5912 |
T9112 |
T9108 |
auxpass |
is,composed |
R5913 |
T9113 |
T9108 |
advmod |
only,composed |
R5914 |
T9114 |
T9108 |
prep |
of,composed |
R5915 |
T9115 |
T9116 |
det |
the,domain |
R5916 |
T9116 |
T9114 |
pobj |
domain,of |
R5917 |
T9117 |
T9116 |
compound |
TACC,domain |
R5918 |
T9118 |
T9105 |
punct |
", ",integrated |
R5919 |
T9119 |
T9120 |
det |
the,members |
R5920 |
T9120 |
T9105 |
nsubj |
members,integrated |
R5921 |
T9121 |
T9122 |
advmod |
significantly,larger |
R5922 |
T9122 |
T9120 |
amod |
larger,members |
R5923 |
T9123 |
T9120 |
compound |
TACC,members |
R5924 |
T9124 |
T9120 |
compound |
family,members |
R5925 |
T9125 |
T9120 |
prep |
in,members |
R5926 |
T9126 |
T9127 |
amod |
higher,protostomes |
R5927 |
T9127 |
T9125 |
pobj |
protostomes,in |
R5928 |
T9128 |
T9127 |
cc |
and,protostomes |
R5929 |
T9129 |
T9127 |
conj |
deuterostomes,protostomes |
R5930 |
T9130 |
T9105 |
aux |
may,integrated |
R5931 |
T9131 |
T9105 |
aux |
have,integrated |
R5932 |
T9132 |
T9133 |
nummod |
one,functions |
R5933 |
T9133 |
T9105 |
dobj |
functions,integrated |
R5934 |
T9134 |
T9132 |
cc |
or,one |
R5935 |
T9135 |
T9132 |
conj |
more,one |
R5936 |
T9136 |
T9133 |
prep |
of,functions |
R5937 |
T9137 |
T9138 |
det |
the,protein |
R5938 |
T9138 |
T9136 |
pobj |
protein,of |
R5939 |
T9139 |
T9138 |
amod |
bridging,protein |
R5940 |
T9140 |
T9138 |
punct |
(,protein |
R5941 |
T9141 |
T9138 |
prep |
in,protein |
R5942 |
T9142 |
T9143 |
det |
this,case |
R5943 |
T9143 |
T9141 |
pobj |
case,in |
R5944 |
T9144 |
T9138 |
appos |
lin15A,protein |
R5945 |
T9145 |
T9144 |
punct |
", ",lin15A |
R5946 |
T9146 |
T9144 |
conj |
lin36,lin15A |
R5947 |
T9147 |
T9146 |
cc |
or,lin36 |
R5948 |
T9148 |
T9146 |
conj |
lin37,lin36 |
R5949 |
T9149 |
T9105 |
punct |
),integrated |
R5950 |
T9150 |
T9105 |
punct |
.,integrated |
R5951 |
T9152 |
T9153 |
nsubj |
This,explain |
R5952 |
T9154 |
T9153 |
aux |
may,explain |
R5953 |
T9155 |
T9153 |
advmod |
also,explain |
R5954 |
T9156 |
T9157 |
det |
the,absence |
R5955 |
T9157 |
T9153 |
dobj |
absence,explain |
R5956 |
T9158 |
T9157 |
prep |
of,absence |
R5957 |
T9159 |
T9160 |
nmod |
lin15A,homologues |
R5958 |
T9160 |
T9158 |
pobj |
homologues,of |
R5959 |
T9161 |
T9159 |
punct |
", ",lin15A |
R5960 |
T9162 |
T9159 |
conj |
lin36,lin15A |
R5961 |
T9163 |
T9162 |
cc |
and,lin36 |
R5962 |
T9164 |
T9162 |
conj |
lin37,lin36 |
R5963 |
T9165 |
T9157 |
prep |
in,absence |
R5964 |
T9166 |
T9167 |
amod |
higher,organisms |
R5965 |
T9167 |
T9165 |
pobj |
organisms,in |
R5966 |
T9168 |
T9153 |
punct |
", ",explain |
R5967 |
T9169 |
T9170 |
mark |
as,were |
R5968 |
T9170 |
T9153 |
advcl |
were,explain |
R5969 |
T9171 |
T9170 |
nsubj |
they,were |
R5970 |
T9172 |
T9173 |
neg |
no,longer |
R5971 |
T9173 |
T9170 |
advmod |
longer,were |
R5972 |
T9174 |
T9170 |
prep |
under,were |
R5973 |
T9175 |
T9176 |
amod |
selective,pressure |
R5974 |
T9176 |
T9174 |
pobj |
pressure,under |
R5975 |
T9177 |
T9176 |
amod |
evolutionary,pressure |
R5976 |
T9178 |
T9179 |
aux |
to,remain |
R5977 |
T9179 |
T9176 |
acl |
remain,pressure |
R5978 |
T9180 |
T9179 |
prep |
within,remain |
R5979 |
T9181 |
T9182 |
det |
the,complex |
R5980 |
T9182 |
T9180 |
pobj |
complex,within |
R5981 |
T9183 |
T9170 |
punct |
", ",were |
R5982 |
T9184 |
T9170 |
cc |
and,were |
R5983 |
T9185 |
T9186 |
advmod |
thus,lost |
R5984 |
T9186 |
T9170 |
conj |
lost,were |
R5985 |
T9187 |
T9186 |
prep |
in,lost |
R5986 |
T9188 |
T9189 |
det |
the,genome |
R5987 |
T9189 |
T9187 |
pobj |
genome,in |
R5988 |
T9190 |
T9189 |
amod |
evolving,genome |
R5989 |
T9191 |
T9153 |
punct |
.,explain |
R8996 |
T13875 |
T13876 |
advmod |
In,vitro |
R8997 |
T13876 |
T13877 |
amod |
vitro,interaction |
R8998 |
T13878 |
T13877 |
prep |
of,interaction |