Id |
Subject |
Object |
Predicate |
Lexical cue |
T6381 |
0-11 |
JJ |
denotes |
Alternative |
T6382 |
12-20 |
NN |
denotes |
splicing |
T6383 |
21-23 |
IN |
denotes |
in |
T6384 |
24-34 |
NN |
denotes |
vertebrate |
T6385 |
40-45 |
NNS |
denotes |
genes |
T6386 |
35-39 |
NN |
denotes |
TACC |
T6387 |
45-317 |
sentence |
denotes |
Whereas exon shuffling can drive the functional diversification of gene families over evolutionary time, the temporal and/or tissue specific alternative splicing of a gene can give rise to functional diversification of a single gene during the development of an organism. |
T6388 |
46-53 |
IN |
denotes |
Whereas |
T6389 |
73-78 |
VB |
denotes |
drive |
T6390 |
54-58 |
NN |
denotes |
exon |
T6391 |
59-68 |
NN |
denotes |
shuffling |
T6392 |
69-72 |
MD |
denotes |
can |
T6393 |
222-226 |
VB |
denotes |
give |
T6394 |
79-82 |
DT |
denotes |
the |
T6395 |
94-109 |
NN |
denotes |
diversification |
T6396 |
83-93 |
JJ |
denotes |
functional |
T6397 |
110-112 |
IN |
denotes |
of |
T6398 |
113-117 |
NN |
denotes |
gene |
T6399 |
118-126 |
NNS |
denotes |
families |
T6400 |
127-131 |
IN |
denotes |
over |
T6401 |
132-144 |
JJ |
denotes |
evolutionary |
T6402 |
145-149 |
NN |
denotes |
time |
T6403 |
149-151 |
, |
denotes |
, |
T6404 |
151-154 |
DT |
denotes |
the |
T6405 |
199-207 |
NN |
denotes |
splicing |
T6406 |
155-163 |
JJ |
denotes |
temporal |
T6407 |
164-167 |
CC |
denotes |
and |
T6408 |
167-168 |
HYPH |
denotes |
/ |
T6409 |
168-170 |
CC |
denotes |
or |
T6410 |
171-177 |
NN |
denotes |
tissue |
T6411 |
178-186 |
JJ |
denotes |
specific |
T6412 |
187-198 |
JJ |
denotes |
alternative |
T6413 |
208-210 |
IN |
denotes |
of |
T6414 |
211-212 |
DT |
denotes |
a |
T6415 |
213-217 |
NN |
denotes |
gene |
T6416 |
218-221 |
MD |
denotes |
can |
T6417 |
227-231 |
NN |
denotes |
rise |
T6418 |
232-234 |
IN |
denotes |
to |
T6419 |
235-245 |
JJ |
denotes |
functional |
T6420 |
246-261 |
NN |
denotes |
diversification |
T6421 |
262-264 |
IN |
denotes |
of |
T6422 |
265-266 |
DT |
denotes |
a |
T6423 |
274-278 |
NN |
denotes |
gene |
T6424 |
267-273 |
JJ |
denotes |
single |
T6425 |
279-285 |
IN |
denotes |
during |
T6426 |
286-289 |
DT |
denotes |
the |
T6427 |
290-301 |
NN |
denotes |
development |
T6428 |
302-304 |
IN |
denotes |
of |
T6429 |
305-307 |
DT |
denotes |
an |
T6430 |
308-316 |
NN |
denotes |
organism |
T6431 |
316-317 |
. |
denotes |
. |
T6432 |
317-473 |
sentence |
denotes |
Although no alternative splicing of TACC3 has been clearly documented, both temporal and tissue specific splicing is observed in the TACC1 and TACC2 genes. |
T6433 |
318-326 |
IN |
denotes |
Although |
T6434 |
377-387 |
VBN |
denotes |
documented |
T6435 |
327-329 |
DT |
denotes |
no |
T6436 |
342-350 |
NN |
denotes |
splicing |
T6437 |
330-341 |
JJ |
denotes |
alternative |
T6438 |
351-353 |
IN |
denotes |
of |
T6439 |
354-359 |
NN |
denotes |
TACC3 |
T6440 |
360-363 |
VBZ |
denotes |
has |
T6441 |
364-368 |
VBN |
denotes |
been |
T6442 |
369-376 |
RB |
denotes |
clearly |
T6443 |
435-443 |
VBN |
denotes |
observed |
T6444 |
387-389 |
, |
denotes |
, |
T6445 |
389-393 |
CC |
denotes |
both |
T6446 |
394-402 |
JJ |
denotes |
temporal |
T6447 |
423-431 |
NN |
denotes |
splicing |
T6448 |
403-406 |
CC |
denotes |
and |
T6449 |
407-413 |
NN |
denotes |
tissue |
T6450 |
414-422 |
JJ |
denotes |
specific |
T6451 |
432-434 |
VBZ |
denotes |
is |
T6452 |
444-446 |
IN |
denotes |
in |
T6453 |
447-450 |
DT |
denotes |
the |
T6454 |
467-472 |
NNS |
denotes |
genes |
T6455 |
451-456 |
NN |
denotes |
TACC1 |
T6456 |
457-460 |
CC |
denotes |
and |
T6457 |
461-466 |
NN |
denotes |
TACC2 |
T6458 |
472-473 |
. |
denotes |
. |
T6459 |
473-629 |
sentence |
denotes |
In the case of TACC2, an additional large (5 kb) exon accounts for the main difference between the major splice variants of the vertebrate TACC2 genes [3]. |
T6460 |
474-476 |
IN |
denotes |
In |
T6461 |
528-536 |
VBZ |
denotes |
accounts |
T6462 |
477-480 |
DT |
denotes |
the |
T6463 |
481-485 |
NN |
denotes |
case |
T6464 |
486-488 |
IN |
denotes |
of |
T6465 |
489-494 |
NN |
denotes |
TACC2 |
T6466 |
494-496 |
, |
denotes |
, |
T6467 |
496-498 |
DT |
denotes |
an |
T6468 |
523-527 |
NN |
denotes |
exon |
T6469 |
499-509 |
JJ |
denotes |
additional |
T6470 |
510-515 |
JJ |
denotes |
large |
T6471 |
516-517 |
-LRB- |
denotes |
( |
T6472 |
519-521 |
NN |
denotes |
kb |
T6473 |
517-518 |
CD |
denotes |
5 |
T6474 |
521-522 |
-RRB- |
denotes |
) |
T6475 |
537-540 |
IN |
denotes |
for |
T6476 |
541-544 |
DT |
denotes |
the |
T6477 |
550-560 |
NN |
denotes |
difference |
T6478 |
545-549 |
JJ |
denotes |
main |
T6479 |
561-568 |
IN |
denotes |
between |
T6480 |
569-572 |
DT |
denotes |
the |
T6481 |
586-594 |
NNS |
denotes |
variants |
T6482 |
573-578 |
JJ |
denotes |
major |
T6483 |
579-585 |
NN |
denotes |
splice |
T6484 |
595-597 |
IN |
denotes |
of |
T6485 |
598-601 |
DT |
denotes |
the |
T6486 |
619-624 |
NNS |
denotes |
genes |
T6487 |
602-612 |
NN |
denotes |
vertebrate |
T6488 |
613-618 |
NN |
denotes |
TACC2 |
T6489 |
625-626 |
-LRB- |
denotes |
[ |
T6490 |
626-627 |
CD |
denotes |
3 |
T6491 |
627-628 |
-RRB- |
denotes |
] |
T6492 |
628-629 |
. |
denotes |
. |
T6493 |
629-856 |
sentence |
denotes |
The alternative splicing of this exon suggests a major functional difference between the two TACC2 isoforms, TACC2s and TACC2l [3], as well as a significant difference between TACC2 and its closest TACC family relative, TACC1. |
T6494 |
630-633 |
DT |
denotes |
The |
T6495 |
646-654 |
NN |
denotes |
splicing |
T6496 |
634-645 |
JJ |
denotes |
alternative |
T6497 |
668-676 |
VBZ |
denotes |
suggests |
T6498 |
655-657 |
IN |
denotes |
of |
T6499 |
658-662 |
DT |
denotes |
this |
T6500 |
663-667 |
NN |
denotes |
exon |
T6501 |
677-678 |
DT |
denotes |
a |
T6502 |
696-706 |
NN |
denotes |
difference |
T6503 |
679-684 |
JJ |
denotes |
major |
T6504 |
685-695 |
JJ |
denotes |
functional |
T6505 |
707-714 |
IN |
denotes |
between |
T6506 |
715-718 |
DT |
denotes |
the |
T6507 |
729-737 |
NNS |
denotes |
isoforms |
T6508 |
719-722 |
CD |
denotes |
two |
T6509 |
723-728 |
NN |
denotes |
TACC2 |
T6510 |
737-739 |
, |
denotes |
, |
T6511 |
739-745 |
NNS |
denotes |
TACC2s |
T6512 |
746-749 |
CC |
denotes |
and |
T6513 |
750-756 |
NN |
denotes |
TACC2l |
T6514 |
757-758 |
-LRB- |
denotes |
[ |
T6515 |
758-759 |
CD |
denotes |
3 |
T6516 |
759-760 |
-RRB- |
denotes |
] |
T6517 |
760-762 |
, |
denotes |
, |
T6518 |
762-764 |
RB |
denotes |
as |
T6519 |
770-772 |
IN |
denotes |
as |
T6520 |
765-769 |
RB |
denotes |
well |
T6521 |
773-774 |
DT |
denotes |
a |
T6522 |
787-797 |
NN |
denotes |
difference |
T6523 |
775-786 |
JJ |
denotes |
significant |
T6524 |
798-805 |
IN |
denotes |
between |
T6525 |
806-811 |
NN |
denotes |
TACC2 |
T6526 |
812-815 |
CC |
denotes |
and |
T6527 |
816-819 |
PRP$ |
denotes |
its |
T6528 |
840-848 |
NN |
denotes |
relative |
T6529 |
820-827 |
JJS |
denotes |
closest |
T6530 |
828-832 |
NN |
denotes |
TACC |
T6531 |
833-839 |
NN |
denotes |
family |
T6532 |
848-850 |
, |
denotes |
, |
T6533 |
850-855 |
NN |
denotes |
TACC1 |
T6534 |
855-856 |
. |
denotes |
. |
T6535 |
856-935 |
sentence |
denotes |
However, the function of this region of the TACC2l isoform is current unknown. |
T6536 |
857-864 |
RB |
denotes |
However |
T6537 |
916-918 |
VBZ |
denotes |
is |
T6538 |
864-866 |
, |
denotes |
, |
T6539 |
866-869 |
DT |
denotes |
the |
T6540 |
870-878 |
NN |
denotes |
function |
T6541 |
879-881 |
IN |
denotes |
of |
T6542 |
882-886 |
DT |
denotes |
this |
T6543 |
887-893 |
NN |
denotes |
region |
T6544 |
894-896 |
IN |
denotes |
of |
T6545 |
897-900 |
DT |
denotes |
the |
T6546 |
908-915 |
NN |
denotes |
isoform |
T6547 |
901-907 |
NN |
denotes |
TACC2l |
T6548 |
919-926 |
RB |
denotes |
current |
T6549 |
927-934 |
JJ |
denotes |
unknown |
T6550 |
934-935 |
. |
denotes |
. |
T6551 |
935-1056 |
sentence |
denotes |
Alternative splicing, together with differential promoter usage has already been noted for the human TACC1 gene [18,19]. |
T6552 |
936-947 |
JJ |
denotes |
Alternative |
T6553 |
948-956 |
NN |
denotes |
splicing |
T6554 |
1017-1022 |
VBN |
denotes |
noted |
T6555 |
956-958 |
, |
denotes |
, |
T6556 |
958-966 |
RB |
denotes |
together |
T6557 |
967-971 |
IN |
denotes |
with |
T6558 |
972-984 |
JJ |
denotes |
differential |
T6559 |
994-999 |
NN |
denotes |
usage |
T6560 |
985-993 |
NN |
denotes |
promoter |
T6561 |
1000-1003 |
VBZ |
denotes |
has |
T6562 |
1004-1011 |
RB |
denotes |
already |
T6563 |
1012-1016 |
VBN |
denotes |
been |
T6564 |
1023-1026 |
IN |
denotes |
for |
T6565 |
1027-1030 |
DT |
denotes |
the |
T6566 |
1043-1047 |
NN |
denotes |
gene |
T6567 |
1031-1036 |
JJ |
denotes |
human |
T6568 |
1037-1042 |
NN |
denotes |
TACC1 |
T6569 |
1048-1049 |
-LRB- |
denotes |
[ |
T6570 |
1052-1054 |
CD |
denotes |
19 |
T6571 |
1049-1051 |
CD |
denotes |
18 |
T6572 |
1051-1052 |
, |
denotes |
, |
T6573 |
1054-1055 |
-RRB- |
denotes |
] |
T6574 |
1055-1056 |
. |
denotes |
. |
T6575 |
1056-1188 |
sentence |
denotes |
In addition, as shown in Fig. 5, we have identified additional TACC1 isoforms that result from alternative splicing of exons 1b-4a. |
T6576 |
1057-1059 |
IN |
denotes |
In |
T6577 |
1098-1108 |
VBN |
denotes |
identified |
T6578 |
1060-1068 |
NN |
denotes |
addition |
T6579 |
1068-1070 |
, |
denotes |
, |
T6580 |
1070-1072 |
IN |
denotes |
as |
T6581 |
1073-1078 |
VBN |
denotes |
shown |
T6582 |
1079-1081 |
IN |
denotes |
in |
T6583 |
1082-1086 |
NN |
denotes |
Fig. |
T6584 |
1087-1088 |
CD |
denotes |
5 |
T6585 |
1088-1090 |
, |
denotes |
, |
T6586 |
1090-1092 |
PRP |
denotes |
we |
T6587 |
1093-1097 |
VBP |
denotes |
have |
T6588 |
1109-1119 |
JJ |
denotes |
additional |
T6589 |
1126-1134 |
NNS |
denotes |
isoforms |
T6590 |
1120-1125 |
NN |
denotes |
TACC1 |
T6591 |
1135-1139 |
WDT |
denotes |
that |
T6592 |
1140-1146 |
VBP |
denotes |
result |
T6593 |
1147-1151 |
IN |
denotes |
from |
T6594 |
1152-1163 |
JJ |
denotes |
alternative |
T6595 |
1164-1172 |
NN |
denotes |
splicing |
T6596 |
1173-1175 |
IN |
denotes |
of |
T6597 |
1176-1181 |
NNS |
denotes |
exons |
T6598 |
1185-1187 |
CD |
denotes |
4a |
T6599 |
1182-1184 |
CD |
denotes |
1b |
T6600 |
1184-1185 |
HYPH |
denotes |
- |
T6601 |
1187-1188 |
. |
denotes |
. |
T6602 |
1188-1472 |
sentence |
denotes |
The functions of these different isoforms are unknown, however the region deleted from the shorter variants can include the binding site for LSm7 [20] (variants C, D, F-I), and/or the nuclear localization signals and binding site for GAS41 [15] and PCTAIRE2BP [20] (isoforms B-D, S). |
T6603 |
1189-1192 |
DT |
denotes |
The |
T6604 |
1193-1202 |
NNS |
denotes |
functions |
T6605 |
1231-1234 |
VBP |
denotes |
are |
T6606 |
1203-1205 |
IN |
denotes |
of |
T6607 |
1206-1211 |
DT |
denotes |
these |
T6608 |
1222-1230 |
NNS |
denotes |
isoforms |
T6609 |
1212-1221 |
JJ |
denotes |
different |
T6610 |
1301-1308 |
VB |
denotes |
include |
T6611 |
1235-1242 |
JJ |
denotes |
unknown |
T6612 |
1242-1244 |
, |
denotes |
, |
T6613 |
1244-1251 |
RB |
denotes |
however |
T6614 |
1252-1255 |
DT |
denotes |
the |
T6615 |
1256-1262 |
NN |
denotes |
region |
T6616 |
1263-1270 |
VBN |
denotes |
deleted |
T6617 |
1271-1275 |
IN |
denotes |
from |
T6618 |
1276-1279 |
DT |
denotes |
the |
T6619 |
1288-1296 |
NNS |
denotes |
variants |
T6620 |
1280-1287 |
JJR |
denotes |
shorter |
T6621 |
1297-1300 |
MD |
denotes |
can |
T6622 |
1309-1312 |
DT |
denotes |
the |
T6623 |
1321-1325 |
NN |
denotes |
site |
T6624 |
1313-1320 |
NN |
denotes |
binding |
T6625 |
1326-1329 |
IN |
denotes |
for |
T6626 |
1330-1334 |
NN |
denotes |
LSm7 |
T6627 |
1335-1336 |
-LRB- |
denotes |
[ |
T6628 |
1336-1338 |
CD |
denotes |
20 |
T6629 |
1338-1339 |
-RRB- |
denotes |
] |
T6630 |
1340-1341 |
-LRB- |
denotes |
( |
T6631 |
1350-1351 |
NN |
denotes |
C |
T6632 |
1341-1349 |
NNS |
denotes |
variants |
T6633 |
1351-1353 |
, |
denotes |
, |
T6634 |
1353-1354 |
NN |
denotes |
D |
T6635 |
1354-1356 |
, |
denotes |
, |
T6636 |
1356-1357 |
NN |
denotes |
F |
T6637 |
1357-1358 |
SYM |
denotes |
- |
T6638 |
1358-1359 |
NN |
denotes |
I |
T6639 |
1359-1360 |
-RRB- |
denotes |
) |
T6640 |
1360-1362 |
, |
denotes |
, |
T6641 |
1362-1365 |
CC |
denotes |
and |
T6642 |
1365-1366 |
HYPH |
denotes |
/ |
T6643 |
1366-1368 |
CC |
denotes |
or |
T6644 |
1369-1372 |
DT |
denotes |
the |
T6645 |
1394-1401 |
NNS |
denotes |
signals |
T6646 |
1373-1380 |
JJ |
denotes |
nuclear |
T6647 |
1381-1393 |
NN |
denotes |
localization |
T6648 |
1402-1405 |
CC |
denotes |
and |
T6649 |
1406-1413 |
NN |
denotes |
binding |
T6650 |
1414-1418 |
NN |
denotes |
site |
T6651 |
1419-1422 |
IN |
denotes |
for |
T6652 |
1423-1428 |
NN |
denotes |
GAS41 |
T6653 |
1429-1430 |
-LRB- |
denotes |
[ |
T6654 |
1430-1432 |
CD |
denotes |
15 |
T6655 |
1432-1433 |
-RRB- |
denotes |
] |
T6656 |
1434-1437 |
CC |
denotes |
and |
T6657 |
1438-1448 |
NN |
denotes |
PCTAIRE2BP |
T6658 |
1449-1450 |
-LRB- |
denotes |
[ |
T6659 |
1450-1452 |
CD |
denotes |
20 |
T6660 |
1452-1453 |
-RRB- |
denotes |
] |
T6661 |
1454-1455 |
-LRB- |
denotes |
( |
T6662 |
1464-1465 |
NN |
denotes |
B |
T6663 |
1455-1463 |
NNS |
denotes |
isoforms |
T6664 |
1465-1466 |
SYM |
denotes |
- |
T6665 |
1466-1467 |
NN |
denotes |
D |
T6666 |
1467-1469 |
, |
denotes |
, |
T6667 |
1469-1470 |
NN |
denotes |
S |
T6668 |
1470-1471 |
-RRB- |
denotes |
) |
T6669 |
1471-1472 |
. |
denotes |
. |
T6670 |
1472-1706 |
sentence |
denotes |
One of these isoforms, TACC1S is localized exclusively to the cytoplasm [19], suggesting that the shorter isoforms would not be able to interact with elements of the chomatin remodeling and/or RNA processing machinery in the nucleus. |
T6671 |
1473-1476 |
CD |
denotes |
One |
T6672 |
1506-1515 |
VBN |
denotes |
localized |
T6673 |
1477-1479 |
IN |
denotes |
of |
T6674 |
1480-1485 |
DT |
denotes |
these |
T6675 |
1486-1494 |
NNS |
denotes |
isoforms |
T6676 |
1494-1496 |
, |
denotes |
, |
T6677 |
1496-1502 |
NN |
denotes |
TACC1S |
T6678 |
1503-1505 |
VBZ |
denotes |
is |
T6679 |
1516-1527 |
RB |
denotes |
exclusively |
T6680 |
1528-1530 |
IN |
denotes |
to |
T6681 |
1531-1534 |
DT |
denotes |
the |
T6682 |
1535-1544 |
NN |
denotes |
cytoplasm |
T6683 |
1545-1546 |
-LRB- |
denotes |
[ |
T6684 |
1546-1548 |
CD |
denotes |
19 |
T6685 |
1548-1549 |
-RRB- |
denotes |
] |
T6686 |
1549-1551 |
, |
denotes |
, |
T6687 |
1551-1561 |
VBG |
denotes |
suggesting |
T6688 |
1562-1566 |
IN |
denotes |
that |
T6689 |
1598-1600 |
VB |
denotes |
be |
T6690 |
1567-1570 |
DT |
denotes |
the |
T6691 |
1579-1587 |
NNS |
denotes |
isoforms |
T6692 |
1571-1578 |
JJR |
denotes |
shorter |
T6693 |
1588-1593 |
MD |
denotes |
would |
T6694 |
1594-1597 |
RB |
denotes |
not |
T6695 |
1601-1605 |
JJ |
denotes |
able |
T6696 |
1606-1608 |
TO |
denotes |
to |
T6697 |
1609-1617 |
VB |
denotes |
interact |
T6698 |
1618-1622 |
IN |
denotes |
with |
T6699 |
1623-1631 |
NNS |
denotes |
elements |
T6700 |
1632-1634 |
IN |
denotes |
of |
T6701 |
1635-1638 |
DT |
denotes |
the |
T6702 |
1648-1658 |
NN |
denotes |
remodeling |
T6703 |
1639-1647 |
NN |
denotes |
chomatin |
T6704 |
1659-1662 |
CC |
denotes |
and |
T6705 |
1662-1663 |
HYPH |
denotes |
/ |
T6706 |
1663-1665 |
CC |
denotes |
or |
T6707 |
1666-1669 |
NN |
denotes |
RNA |
T6708 |
1681-1690 |
NN |
denotes |
machinery |
T6709 |
1670-1680 |
NN |
denotes |
processing |
T6710 |
1691-1693 |
IN |
denotes |
in |
T6711 |
1694-1697 |
DT |
denotes |
the |
T6712 |
1698-1705 |
NN |
denotes |
nucleus |
T6713 |
1705-1706 |
. |
denotes |
. |
T6714 |
1706-1973 |
sentence |
denotes |
Thus, changes in the complement of TACC1 isoforms in the cell may result in alterations in cellular RNA metabolism at multiple levels, and may account for the observation that TACC1D and TACC1F isoforms are associated with tumorigenic changes in gastric mucosa [18]. |
T6715 |
1707-1711 |
RB |
denotes |
Thus |
T6716 |
1773-1779 |
VB |
denotes |
result |
T6717 |
1711-1713 |
, |
denotes |
, |
T6718 |
1713-1720 |
NNS |
denotes |
changes |
T6719 |
1721-1723 |
IN |
denotes |
in |
T6720 |
1724-1727 |
DT |
denotes |
the |
T6721 |
1728-1738 |
NN |
denotes |
complement |
T6722 |
1739-1741 |
IN |
denotes |
of |
T6723 |
1742-1747 |
NN |
denotes |
TACC1 |
T6724 |
1748-1756 |
NNS |
denotes |
isoforms |
T6725 |
1757-1759 |
IN |
denotes |
in |
T6726 |
1760-1763 |
DT |
denotes |
the |
T6727 |
1764-1768 |
NN |
denotes |
cell |
T6728 |
1769-1772 |
MD |
denotes |
may |
T6729 |
1780-1782 |
IN |
denotes |
in |
T6730 |
1783-1794 |
NNS |
denotes |
alterations |
T6731 |
1795-1797 |
IN |
denotes |
in |
T6732 |
1798-1806 |
JJ |
denotes |
cellular |
T6733 |
1811-1821 |
NN |
denotes |
metabolism |
T6734 |
1807-1810 |
NN |
denotes |
RNA |
T6735 |
1822-1824 |
IN |
denotes |
at |
T6736 |
1825-1833 |
JJ |
denotes |
multiple |
T6737 |
1834-1840 |
NNS |
denotes |
levels |
T6738 |
1840-1842 |
, |
denotes |
, |
T6739 |
1842-1845 |
CC |
denotes |
and |
T6740 |
1846-1849 |
MD |
denotes |
may |
T6741 |
1850-1857 |
VB |
denotes |
account |
T6742 |
1858-1861 |
IN |
denotes |
for |
T6743 |
1862-1865 |
DT |
denotes |
the |
T6744 |
1866-1877 |
NN |
denotes |
observation |
T6745 |
1878-1882 |
IN |
denotes |
that |
T6746 |
1914-1924 |
VBN |
denotes |
associated |
T6747 |
1883-1889 |
NN |
denotes |
TACC1D |
T6748 |
1901-1909 |
NNS |
denotes |
isoforms |
T6749 |
1890-1893 |
CC |
denotes |
and |
T6750 |
1894-1900 |
NN |
denotes |
TACC1F |
T6751 |
1910-1913 |
VBP |
denotes |
are |
T6752 |
1925-1929 |
IN |
denotes |
with |
T6753 |
1930-1941 |
JJ |
denotes |
tumorigenic |
T6754 |
1942-1949 |
NNS |
denotes |
changes |
T6755 |
1950-1952 |
IN |
denotes |
in |
T6756 |
1953-1960 |
JJ |
denotes |
gastric |
T6757 |
1961-1967 |
NN |
denotes |
mucosa |
T6758 |
1968-1969 |
-LRB- |
denotes |
[ |
T6759 |
1969-1971 |
CD |
denotes |
18 |
T6760 |
1971-1972 |
-RRB- |
denotes |
] |
T6761 |
1972-1973 |
. |
denotes |
. |
T13211 |
1984-1995 |
JJ |
denotes |
Alternative |
T13212 |
1996-2004 |
NN |
denotes |
splicing |
T13213 |
2005-2007 |
IN |
denotes |
of |
T13214 |
2008-2011 |
DT |
denotes |
the |
T13215 |
2024-2028 |
NN |
denotes |
gene |
T13216 |
2012-2017 |
JJ |
denotes |
human |
T13217 |
2018-2023 |
NN |
denotes |
TACC1 |
T13218 |
2028-2029 |
. |
denotes |
. |
T13219 |
2029-2106 |
sentence |
denotes |
(A): Seven splice variants have been identified for human TACC1 (A-F and S). |
T13220 |
2030-2031 |
-LRB- |
denotes |
( |
T13221 |
2031-2032 |
LS |
denotes |
A |
T13222 |
2067-2077 |
VBN |
denotes |
identified |
T13223 |
2032-2033 |
-RRB- |
denotes |
) |
T13224 |
2033-2035 |
: |
denotes |
: |
T13225 |
2035-2040 |
CD |
denotes |
Seven |
T13226 |
2048-2056 |
NNS |
denotes |
variants |
T13227 |
2041-2047 |
NN |
denotes |
splice |
T13228 |
2057-2061 |
VBP |
denotes |
have |
T13229 |
2062-2066 |
VBN |
denotes |
been |
T13230 |
2078-2081 |
IN |
denotes |
for |
T13231 |
2082-2087 |
JJ |
denotes |
human |
T13232 |
2088-2093 |
NN |
denotes |
TACC1 |
T13233 |
2094-2095 |
-LRB- |
denotes |
( |
T13234 |
2095-2096 |
NN |
denotes |
A |
T13235 |
2096-2097 |
SYM |
denotes |
- |
T13236 |
2097-2098 |
NN |
denotes |
F |
T13237 |
2099-2102 |
CC |
denotes |
and |
T13238 |
2103-2104 |
NN |
denotes |
S |
T13239 |
2104-2105 |
-RRB- |
denotes |
) |
T13240 |
2105-2106 |
. |
denotes |
. |
T13241 |
2106-2226 |
sentence |
denotes |
We have also identified additional splice variants (G-I) from database analysis and rt-PCR analysis of human brain RNA. |
T13242 |
2107-2109 |
PRP |
denotes |
We |
T13243 |
2120-2130 |
VBN |
denotes |
identified |
T13244 |
2110-2114 |
VBP |
denotes |
have |
T13245 |
2115-2119 |
RB |
denotes |
also |
T13246 |
2131-2141 |
JJ |
denotes |
additional |
T13247 |
2149-2157 |
NNS |
denotes |
variants |
T13248 |
2142-2148 |
NN |
denotes |
splice |
T13249 |
2158-2159 |
-LRB- |
denotes |
( |
T13250 |
2159-2160 |
NN |
denotes |
G |
T13251 |
2160-2161 |
SYM |
denotes |
- |
T13252 |
2161-2162 |
NN |
denotes |
I |
T13253 |
2162-2163 |
-RRB- |
denotes |
) |
T13254 |
2164-2168 |
IN |
denotes |
from |
T13255 |
2169-2177 |
NN |
denotes |
database |
T13256 |
2178-2186 |
NN |
denotes |
analysis |
T13257 |
2187-2190 |
CC |
denotes |
and |
T13258 |
2191-2193 |
NN |
denotes |
rt |
T13259 |
2194-2197 |
NN |
denotes |
PCR |
T13260 |
2193-2194 |
HYPH |
denotes |
- |
T13261 |
2198-2206 |
NN |
denotes |
analysis |
T13262 |
2207-2209 |
IN |
denotes |
of |
T13263 |
2210-2215 |
JJ |
denotes |
human |
T13264 |
2216-2221 |
NN |
denotes |
brain |
T13265 |
2222-2225 |
NN |
denotes |
RNA |
T13266 |
2225-2226 |
. |
denotes |
. |
T13267 |
2226-2281 |
sentence |
denotes |
(B): Alternative splicing of TACC1 in the human brain. |
T13268 |
2227-2228 |
-LRB- |
denotes |
( |
T13269 |
2228-2229 |
LS |
denotes |
B |
T13270 |
2244-2252 |
NN |
denotes |
splicing |
T13271 |
2229-2230 |
-RRB- |
denotes |
) |
T13272 |
2230-2232 |
: |
denotes |
: |
T13273 |
2232-2243 |
JJ |
denotes |
Alternative |
T13274 |
2253-2255 |
IN |
denotes |
of |
T13275 |
2256-2261 |
NN |
denotes |
TACC1 |
T13276 |
2262-2264 |
IN |
denotes |
in |
T13277 |
2265-2268 |
DT |
denotes |
the |
T13278 |
2275-2280 |
NN |
denotes |
brain |
T13279 |
2269-2274 |
JJ |
denotes |
human |
T13280 |
2280-2281 |
. |
denotes |
. |
T13281 |
2281-2456 |
sentence |
denotes |
rt-PCR analysis confirms splicing of the untranslated exon 1a to exon 1, with retention of the originally defined start methionine (GB:NP_006274) (Variant A*, lanes 1 and 3). |
T13282 |
2282-2284 |
NN |
denotes |
rt |
T13283 |
2285-2288 |
NN |
denotes |
PCR |
T13284 |
2284-2285 |
HYPH |
denotes |
- |
T13285 |
2289-2297 |
NN |
denotes |
analysis |
T13286 |
2298-2306 |
VBZ |
denotes |
confirms |
T13287 |
2307-2315 |
NN |
denotes |
splicing |
T13288 |
2316-2318 |
IN |
denotes |
of |
T13289 |
2319-2322 |
DT |
denotes |
the |
T13290 |
2336-2340 |
NN |
denotes |
exon |
T13291 |
2323-2335 |
JJ |
denotes |
untranslated |
T13292 |
2341-2343 |
CD |
denotes |
1a |
T13293 |
2344-2346 |
IN |
denotes |
to |
T13294 |
2347-2351 |
NN |
denotes |
exon |
T13295 |
2352-2353 |
CD |
denotes |
1 |
T13296 |
2353-2355 |
, |
denotes |
, |
T13297 |
2355-2359 |
IN |
denotes |
with |
T13298 |
2360-2369 |
NN |
denotes |
retention |
T13299 |
2370-2372 |
IN |
denotes |
of |
T13300 |
2373-2376 |
DT |
denotes |
the |
T13301 |
2402-2412 |
NN |
denotes |
methionine |
T13302 |
2377-2387 |
RB |
denotes |
originally |
T13303 |
2388-2395 |
VBN |
denotes |
defined |
T13304 |
2396-2401 |
NN |
denotes |
start |
T13305 |
2413-2414 |
-LRB- |
denotes |
( |
T13306 |
2417-2426 |
NN |
denotes |
NP_006274 |
T13307 |
2414-2416 |
NN |
denotes |
GB |
T13308 |
2416-2417 |
: |
denotes |
: |
T13309 |
2426-2427 |
-RRB- |
denotes |
) |
T13310 |
2428-2429 |
-LRB- |
denotes |
( |
T13311 |
2447-2448 |
CD |
denotes |
1 |
T13312 |
2429-2436 |
NN |
denotes |
Variant |
T13313 |
2437-2438 |
NN |
denotes |
A |
T13314 |
2438-2439 |
SYM |
denotes |
* |
T13315 |
2439-2441 |
, |
denotes |
, |
T13316 |
2441-2446 |
NNS |
denotes |
lanes |
T13317 |
2449-2452 |
CC |
denotes |
and |
T13318 |
2453-2454 |
CD |
denotes |
3 |
T13319 |
2454-2455 |
-RRB- |
denotes |
) |
T13320 |
2455-2456 |
. |
denotes |
. |
T13321 |
2456-2553 |
sentence |
denotes |
Exon 1a also splices to exon 2, removing the L-Sm7 binding motif (variant I, lanes 3,12 and 13). |
T13322 |
2457-2461 |
NN |
denotes |
Exon |
T13323 |
2470-2477 |
VBZ |
denotes |
splices |
T13324 |
2462-2464 |
CD |
denotes |
1a |
T13325 |
2465-2469 |
RB |
denotes |
also |
T13326 |
2478-2480 |
IN |
denotes |
to |
T13327 |
2481-2485 |
NN |
denotes |
exon |
T13328 |
2486-2487 |
CD |
denotes |
2 |
T13329 |
2487-2489 |
, |
denotes |
, |
T13330 |
2489-2497 |
VBG |
denotes |
removing |
T13331 |
2498-2501 |
DT |
denotes |
the |
T13332 |
2516-2521 |
NN |
denotes |
motif |
T13333 |
2502-2503 |
NN |
denotes |
L |
T13334 |
2504-2507 |
NN |
denotes |
Sm7 |
T13335 |
2503-2504 |
HYPH |
denotes |
- |
T13336 |
2508-2515 |
NN |
denotes |
binding |
T13337 |
2522-2523 |
-LRB- |
denotes |
( |
T13338 |
2540-2541 |
CD |
denotes |
3 |
T13339 |
2523-2530 |
NN |
denotes |
variant |
T13340 |
2531-2532 |
NN |
denotes |
I |
T13341 |
2532-2534 |
, |
denotes |
, |
T13342 |
2534-2539 |
NNS |
denotes |
lanes |
T13343 |
2541-2542 |
, |
denotes |
, |
T13344 |
2542-2544 |
CD |
denotes |
12 |
T13345 |
2545-2548 |
CC |
denotes |
and |
T13346 |
2549-2551 |
CD |
denotes |
13 |
T13347 |
2551-2552 |
-RRB- |
denotes |
) |
T13348 |
2552-2553 |
. |
denotes |
. |
T13349 |
2553-2739 |
sentence |
denotes |
Variants that functionally delete exons 2 and/or 3, such as variant C (lane 15) also remove the predicted nuclear localization signals, and the binding domains for GAS41 and PCTAIRE2BP. |
T13350 |
2554-2562 |
NNS |
denotes |
Variants |
T13351 |
2639-2645 |
VBP |
denotes |
remove |
T13352 |
2563-2567 |
WDT |
denotes |
that |
T13353 |
2581-2587 |
VBP |
denotes |
delete |
T13354 |
2568-2580 |
RB |
denotes |
functionally |
T13355 |
2588-2593 |
NNS |
denotes |
exons |
T13356 |
2594-2595 |
CD |
denotes |
2 |
T13357 |
2596-2599 |
CC |
denotes |
and |
T13358 |
2599-2600 |
HYPH |
denotes |
/ |
T13359 |
2600-2602 |
CC |
denotes |
or |
T13360 |
2603-2604 |
CD |
denotes |
3 |
T13361 |
2604-2606 |
, |
denotes |
, |
T13362 |
2606-2610 |
JJ |
denotes |
such |
T13363 |
2611-2613 |
IN |
denotes |
as |
T13364 |
2614-2621 |
NN |
denotes |
variant |
T13365 |
2622-2623 |
NN |
denotes |
C |
T13366 |
2624-2625 |
-LRB- |
denotes |
( |
T13367 |
2625-2629 |
NN |
denotes |
lane |
T13368 |
2630-2632 |
CD |
denotes |
15 |
T13369 |
2632-2633 |
-RRB- |
denotes |
) |
T13370 |
2634-2638 |
RB |
denotes |
also |
T13371 |
2646-2649 |
DT |
denotes |
the |
T13372 |
2681-2688 |
NNS |
denotes |
signals |
T13373 |
2650-2659 |
VBN |
denotes |
predicted |
T13374 |
2660-2667 |
JJ |
denotes |
nuclear |
T13375 |
2668-2680 |
NN |
denotes |
localization |
T13376 |
2688-2690 |
, |
denotes |
, |
T13377 |
2690-2693 |
CC |
denotes |
and |
T13378 |
2694-2697 |
DT |
denotes |
the |
T13379 |
2706-2713 |
NNS |
denotes |
domains |
T13380 |
2698-2705 |
NN |
denotes |
binding |
T13381 |
2714-2717 |
IN |
denotes |
for |
T13382 |
2718-2723 |
NN |
denotes |
GAS41 |
T13383 |
2724-2727 |
CC |
denotes |
and |
T13384 |
2728-2738 |
NN |
denotes |
PCTAIRE2BP |
T13385 |
2738-2739 |
. |
denotes |
. |
T13386 |
2739-2869 |
sentence |
denotes |
These variants would retain the TACC domain, and therefore the potential to bind to ch-TOG and Aurora A kinase in the centrosome. |
T13387 |
2740-2745 |
DT |
denotes |
These |
T13388 |
2746-2754 |
NNS |
denotes |
variants |
T13389 |
2761-2767 |
VB |
denotes |
retain |
T13390 |
2755-2760 |
MD |
denotes |
would |
T13391 |
2768-2771 |
DT |
denotes |
the |
T13392 |
2777-2783 |
NN |
denotes |
domain |
T13393 |
2772-2776 |
NN |
denotes |
TACC |
T13394 |
2783-2785 |
, |
denotes |
, |
T13395 |
2785-2788 |
CC |
denotes |
and |
T13396 |
2789-2798 |
RB |
denotes |
therefore |
T13397 |
2803-2812 |
NN |
denotes |
potential |
T13398 |
2799-2802 |
DT |
denotes |
the |
T13399 |
2813-2815 |
TO |
denotes |
to |
T13400 |
2816-2820 |
VB |
denotes |
bind |
T13401 |
2821-2823 |
IN |
denotes |
to |
T13402 |
2824-2826 |
NN |
denotes |
ch |
T13403 |
2827-2830 |
NN |
denotes |
TOG |
T13404 |
2826-2827 |
HYPH |
denotes |
- |
T13405 |
2831-2834 |
CC |
denotes |
and |
T13406 |
2835-2841 |
NN |
denotes |
Aurora |
T13407 |
2842-2843 |
NN |
denotes |
A |
T13408 |
2844-2850 |
NN |
denotes |
kinase |
T13409 |
2851-2853 |
IN |
denotes |
in |
T13410 |
2854-2857 |
DT |
denotes |
the |
T13411 |
2858-2868 |
NN |
denotes |
centrosome |
T13412 |
2868-2869 |
. |
denotes |
. |
T13413 |
2869-3174 |
sentence |
denotes |
Lane 1: EF/X1R, Lane 2: EF/BX647R, Lane 3: EF/6SPR, Lane 4: EF/1DR, Lane 5, EF/128R, Lane 6 X3F/X1R, Lane 7: X3F/BX647R, Lane 8: X3F/6SPR, Lane 9: X3F/1DR, Lane 10, X3F/128R, Lane 11: 1DF/X1R, Lane 12: 1DF/BX647R, Lane 13: 1DF/6SPR, Lane 14: 1DF/1DR, Lane 15: 1DF/128R, Lane 16: Biorad 1 kb+ Size ladder. |
T13414 |
2870-2874 |
NN |
denotes |
Lane |
T13415 |
2881-2884 |
NN |
denotes |
X1R |
T13416 |
2875-2876 |
CD |
denotes |
1 |
T13417 |
2876-2878 |
: |
denotes |
: |
T13418 |
2878-2880 |
NN |
denotes |
EF |
T13419 |
2880-2881 |
HYPH |
denotes |
/ |
T13420 |
3167-3173 |
NN |
denotes |
ladder |
T13421 |
2884-2886 |
, |
denotes |
, |
T13422 |
2886-2890 |
NN |
denotes |
Lane |
T13423 |
2897-2903 |
NN |
denotes |
BX647R |
T13424 |
2891-2892 |
CD |
denotes |
2 |
T13425 |
2892-2894 |
: |
denotes |
: |
T13426 |
2894-2896 |
NN |
denotes |
EF |
T13427 |
2896-2897 |
HYPH |
denotes |
/ |
T13428 |
2903-2905 |
, |
denotes |
, |
T13429 |
2905-2909 |
NN |
denotes |
Lane |
T13430 |
2916-2920 |
NN |
denotes |
6SPR |
T13431 |
2910-2911 |
CD |
denotes |
3 |
T13432 |
2911-2913 |
: |
denotes |
: |
T13433 |
2913-2915 |
NN |
denotes |
EF |
T13434 |
2915-2916 |
HYPH |
denotes |
/ |
T13435 |
2920-2922 |
, |
denotes |
, |
T13436 |
2922-2926 |
NN |
denotes |
Lane |
T13437 |
2933-2936 |
NN |
denotes |
1DR |
T13438 |
2927-2928 |
CD |
denotes |
4 |
T13439 |
2928-2930 |
: |
denotes |
: |
T13440 |
2930-2932 |
NN |
denotes |
EF |
T13441 |
2932-2933 |
HYPH |
denotes |
/ |
T13442 |
2936-2938 |
, |
denotes |
, |
T13443 |
2938-2942 |
NN |
denotes |
Lane |
T13444 |
2949-2953 |
NN |
denotes |
128R |
T13445 |
2943-2944 |
CD |
denotes |
5 |
T13446 |
2944-2946 |
, |
denotes |
, |
T13447 |
2946-2948 |
NN |
denotes |
EF |
T13448 |
2948-2949 |
HYPH |
denotes |
/ |
T13449 |
2953-2955 |
, |
denotes |
, |
T13450 |
2955-2959 |
NN |
denotes |
Lane |
T13451 |
2966-2969 |
NN |
denotes |
X1R |
T13452 |
2960-2961 |
CD |
denotes |
6 |
T13453 |
2962-2965 |
NN |
denotes |
X3F |
T13454 |
2965-2966 |
HYPH |
denotes |
/ |
T13455 |
2969-2971 |
, |
denotes |
, |
T13456 |
2971-2975 |
NN |
denotes |
Lane |
T13457 |
2983-2989 |
NN |
denotes |
BX647R |
T13458 |
2976-2977 |
CD |
denotes |
7 |
T13459 |
2977-2979 |
: |
denotes |
: |
T13460 |
2979-2982 |
NN |
denotes |
X3F |
T13461 |
2982-2983 |
HYPH |
denotes |
/ |
T13462 |
2989-2991 |
, |
denotes |
, |
T13463 |
2991-2995 |
NN |
denotes |
Lane |
T13464 |
3003-3007 |
NN |
denotes |
6SPR |
T13465 |
2996-2997 |
CD |
denotes |
8 |
T13466 |
2997-2999 |
: |
denotes |
: |
T13467 |
2999-3002 |
NN |
denotes |
X3F |
T13468 |
3002-3003 |
HYPH |
denotes |
/ |
T13469 |
3007-3009 |
, |
denotes |
, |
T13470 |
3009-3013 |
NN |
denotes |
Lane |
T13471 |
3021-3024 |
NN |
denotes |
1DR |
T13472 |
3014-3015 |
CD |
denotes |
9 |
T13473 |
3015-3017 |
: |
denotes |
: |
T13474 |
3017-3020 |
NN |
denotes |
X3F |
T13475 |
3020-3021 |
HYPH |
denotes |
/ |
T13476 |
3024-3026 |
, |
denotes |
, |
T13477 |
3026-3030 |
NN |
denotes |
Lane |
T13478 |
3039-3043 |
NN |
denotes |
128R |
T13479 |
3031-3033 |
CD |
denotes |
10 |
T13480 |
3033-3035 |
, |
denotes |
, |
T13481 |
3035-3038 |
NN |
denotes |
X3F |
T13482 |
3038-3039 |
HYPH |
denotes |
/ |
T13483 |
3043-3045 |
, |
denotes |
, |
T13484 |
3045-3049 |
NN |
denotes |
Lane |
T13485 |
3058-3061 |
NN |
denotes |
X1R |
T13486 |
3050-3052 |
CD |
denotes |
11 |
T13487 |
3052-3054 |
: |
denotes |
: |
T13488 |
3054-3057 |
NN |
denotes |
1DF |
T13489 |
3057-3058 |
HYPH |
denotes |
/ |
T13490 |
3061-3063 |
, |
denotes |
, |
T13491 |
3063-3067 |
NN |
denotes |
Lane |
T13492 |
3076-3082 |
NN |
denotes |
BX647R |
T13493 |
3068-3070 |
CD |
denotes |
12 |
T13494 |
3070-3072 |
: |
denotes |
: |
T13495 |
3072-3075 |
NN |
denotes |
1DF |
T13496 |
3075-3076 |
HYPH |
denotes |
/ |
T13497 |
3082-3084 |
, |
denotes |
, |
T13498 |
3084-3088 |
NN |
denotes |
Lane |
T13499 |
3097-3101 |
NN |
denotes |
6SPR |
T13500 |
3089-3091 |
CD |
denotes |
13 |
T13501 |
3091-3093 |
: |
denotes |
: |
T13502 |
3093-3096 |
NN |
denotes |
1DF |
T13503 |
3096-3097 |
HYPH |
denotes |
/ |
T13504 |
3101-3103 |
, |
denotes |
, |
T13505 |
3103-3107 |
NN |
denotes |
Lane |
T13506 |
3116-3119 |
NN |
denotes |
1DR |
T13507 |
3108-3110 |
CD |
denotes |
14 |
T13508 |
3110-3112 |
: |
denotes |
: |
T13509 |
3112-3115 |
NN |
denotes |
1DF |
T13510 |
3115-3116 |
HYPH |
denotes |
/ |
T13511 |
3119-3121 |
, |
denotes |
, |
T13512 |
3121-3125 |
NN |
denotes |
Lane |
T13513 |
3134-3138 |
NN |
denotes |
128R |
T13514 |
3126-3128 |
CD |
denotes |
15 |
T13515 |
3128-3130 |
: |
denotes |
: |
T13516 |
3130-3133 |
NN |
denotes |
1DF |
T13517 |
3133-3134 |
HYPH |
denotes |
/ |
T13518 |
3138-3140 |
, |
denotes |
, |
T13519 |
3140-3144 |
NN |
denotes |
Lane |
T13520 |
3145-3147 |
CD |
denotes |
16 |
T13521 |
3147-3149 |
: |
denotes |
: |
T13522 |
3149-3155 |
NNP |
denotes |
Biorad |
T13523 |
3156-3157 |
CD |
denotes |
1 |
T13524 |
3158-3161 |
NN |
denotes |
kb+ |
T13525 |
3162-3166 |
NN |
denotes |
Size |
T13526 |
3173-3174 |
. |
denotes |
. |
R8490 |
T13211 |
T13212 |
amod |
Alternative,splicing |
R8491 |
T13213 |
T13212 |
prep |
of,splicing |
R8492 |
T13214 |
T13215 |
det |
the,gene |
R8493 |
T13215 |
T13213 |
pobj |
gene,of |
R8494 |
T13216 |
T13215 |
amod |
human,gene |
R8495 |
T13217 |
T13215 |
compound |
TACC1,gene |
R8496 |
T13218 |
T13212 |
punct |
.,splicing |
R8497 |
T13220 |
T13221 |
punct |
(,A |
R8498 |
T13221 |
T13222 |
meta |
A,identified |
R8499 |
T13223 |
T13221 |
punct |
),A |
R8500 |
T13224 |
T13222 |
punct |
: ,identified |
R8501 |
T13225 |
T13226 |
nummod |
Seven,variants |
R8502 |
T13226 |
T13222 |
nsubjpass |
variants,identified |
R8503 |
T13227 |
T13226 |
compound |
splice,variants |
R8504 |
T13228 |
T13222 |
aux |
have,identified |
R8505 |
T13229 |
T13222 |
auxpass |
been,identified |
R8506 |
T13230 |
T13222 |
prep |
for,identified |
R8507 |
T13231 |
T13232 |
amod |
human,TACC1 |
R8508 |
T13232 |
T13230 |
pobj |
TACC1,for |
R8509 |
T13233 |
T13234 |
punct |
(,A |
R8510 |
T13234 |
T13222 |
parataxis |
A,identified |
R8511 |
T13235 |
T13236 |
punct |
-,F |
R8512 |
T13236 |
T13234 |
prep |
F,A |
R8513 |
T13237 |
T13234 |
cc |
and,A |
R8514 |
T13238 |
T13234 |
conj |
S,A |
R8515 |
T13239 |
T13234 |
punct |
),A |
R8516 |
T13240 |
T13222 |
punct |
.,identified |
R8517 |
T13242 |
T13243 |
nsubj |
We,identified |
R8518 |
T13244 |
T13243 |
aux |
have,identified |
R8519 |
T13245 |
T13243 |
advmod |
also,identified |
R8520 |
T13246 |
T13247 |
amod |
additional,variants |
R8521 |
T13247 |
T13243 |
dobj |
variants,identified |
R8522 |
T13248 |
T13247 |
compound |
splice,variants |
R8523 |
T13249 |
T13250 |
punct |
(,G |
R8524 |
T13250 |
T13247 |
parataxis |
G,variants |
R8525 |
T13251 |
T13252 |
punct |
-,I |
R8526 |
T13252 |
T13250 |
prep |
I,G |
R8527 |
T13253 |
T13250 |
punct |
),G |
R8528 |
T13254 |
T13243 |
prep |
from,identified |
R8529 |
T13255 |
T13256 |
compound |
database,analysis |
R8530 |
T13256 |
T13254 |
pobj |
analysis,from |
R8531 |
T13257 |
T13256 |
cc |
and,analysis |
R8532 |
T13258 |
T13259 |
compound |
rt,PCR |
R8533 |
T13259 |
T13261 |
compound |
PCR,analysis |
R8534 |
T13260 |
T13259 |
punct |
-,PCR |
R8535 |
T13261 |
T13256 |
conj |
analysis,analysis |
R8536 |
T13262 |
T13261 |
prep |
of,analysis |
R8537 |
T13263 |
T13264 |
amod |
human,brain |
R8538 |
T13264 |
T13265 |
compound |
brain,RNA |
R8539 |
T13265 |
T13262 |
pobj |
RNA,of |
R8540 |
T13266 |
T13243 |
punct |
.,identified |
R8541 |
T13268 |
T13269 |
punct |
(,B |
R8542 |
T13269 |
T13270 |
meta |
B,splicing |
R8543 |
T13271 |
T13269 |
punct |
),B |
R8544 |
T13272 |
T13270 |
punct |
: ,splicing |
R8545 |
T13273 |
T13270 |
amod |
Alternative,splicing |
R8546 |
T13274 |
T13270 |
prep |
of,splicing |
R8547 |
T13275 |
T13274 |
pobj |
TACC1,of |
R8548 |
T13276 |
T13270 |
prep |
in,splicing |
R8549 |
T13277 |
T13278 |
det |
the,brain |
R8550 |
T13278 |
T13276 |
pobj |
brain,in |
R8551 |
T13279 |
T13278 |
amod |
human,brain |
R8552 |
T13280 |
T13270 |
punct |
.,splicing |
R8553 |
T13282 |
T13283 |
compound |
rt,PCR |
R8554 |
T13283 |
T13285 |
compound |
PCR,analysis |
R8555 |
T13284 |
T13283 |
punct |
-,PCR |
R8556 |
T13285 |
T13286 |
nsubj |
analysis,confirms |
R8557 |
T13287 |
T13286 |
dobj |
splicing,confirms |
R8558 |
T13288 |
T13287 |
prep |
of,splicing |
R8559 |
T13289 |
T13290 |
det |
the,exon |
R8560 |
T13290 |
T13288 |
pobj |
exon,of |
R8561 |
T13291 |
T13290 |
amod |
untranslated,exon |
R8562 |
T13292 |
T13290 |
nummod |
1a,exon |
R8563 |
T13293 |
T13287 |
prep |
to,splicing |
R8564 |
T13294 |
T13293 |
pobj |
exon,to |
R8565 |
T13295 |
T13294 |
nummod |
1,exon |
R8566 |
T13296 |
T13287 |
punct |
", ",splicing |
R8567 |
T13297 |
T13287 |
prep |
with,splicing |
R8568 |
T13298 |
T13297 |
pobj |
retention,with |
R8569 |
T13299 |
T13298 |
prep |
of,retention |
R8570 |
T13300 |
T13301 |
det |
the,methionine |
R8571 |
T13301 |
T13299 |
pobj |
methionine,of |
R8572 |
T13302 |
T13303 |
advmod |
originally,defined |
R8573 |
T13303 |
T13301 |
amod |
defined,methionine |
R8574 |
T13304 |
T13301 |
compound |
start,methionine |
R8575 |
T13305 |
T13306 |
punct |
(,NP_006274 |
R8576 |
T13306 |
T13286 |
parataxis |
NP_006274,confirms |
R8577 |
T13307 |
T13306 |
nmod |
GB,NP_006274 |
R8578 |
T13308 |
T13306 |
punct |
:,NP_006274 |
R8579 |
T13309 |
T13306 |
punct |
),NP_006274 |
R8580 |
T13310 |
T13311 |
punct |
(,1 |
R8581 |
T13311 |
T13286 |
parataxis |
1,confirms |
R8582 |
T13312 |
T13313 |
compound |
Variant,A |
R8583 |
T13313 |
T13311 |
dep |
A,1 |
R8584 |
T13314 |
T13313 |
punct |
*,A |
R8585 |
T13315 |
T13311 |
punct |
", ",1 |
R8586 |
T13316 |
T13311 |
nmod |
lanes,1 |
R8587 |
T13317 |
T13311 |
cc |
and,1 |
R8588 |
T13318 |
T13311 |
conj |
3,1 |
R8589 |
T13319 |
T13311 |
punct |
),1 |
R8590 |
T13320 |
T13286 |
punct |
.,confirms |
R8591 |
T13322 |
T13323 |
nsubj |
Exon,splices |
R8592 |
T13324 |
T13322 |
nummod |
1a,Exon |
R8593 |
T13325 |
T13323 |
advmod |
also,splices |
R8594 |
T13326 |
T13323 |
prep |
to,splices |
R8595 |
T13327 |
T13326 |
pobj |
exon,to |
R8596 |
T13328 |
T13327 |
nummod |
2,exon |
R8597 |
T13329 |
T13323 |
punct |
", ",splices |
R8598 |
T13330 |
T13323 |
advcl |
removing,splices |
R8599 |
T13331 |
T13332 |
det |
the,motif |
R8600 |
T13332 |
T13330 |
dobj |
motif,removing |
R8601 |
T13333 |
T13334 |
compound |
L,Sm7 |
R8602 |
T13334 |
T13332 |
compound |
Sm7,motif |
R8603 |
T13335 |
T13334 |
punct |
-,Sm7 |
R8604 |
T13336 |
T13332 |
compound |
binding,motif |
R8605 |
T13337 |
T13338 |
punct |
(,3 |
R8606 |
T13338 |
T13323 |
parataxis |
3,splices |
R8607 |
T13339 |
T13340 |
compound |
variant,I |
R8608 |
T13340 |
T13338 |
dep |
I,3 |
R8609 |
T13341 |
T13338 |
punct |
", ",3 |
R8610 |
T13342 |
T13338 |
nmod |
lanes,3 |
R8611 |
T13343 |
T13338 |
punct |
",",3 |
R8612 |
T13344 |
T13338 |
conj |
12,3 |
R8613 |
T13345 |
T13344 |
cc |
and,12 |
R8614 |
T13346 |
T13344 |
conj |
13,12 |
R8615 |
T13347 |
T13338 |
punct |
),3 |
R8616 |
T13348 |
T13323 |
punct |
.,splices |
R8617 |
T13350 |
T13351 |
nsubj |
Variants,remove |
R8618 |
T13352 |
T13353 |
dep |
that,delete |
R8619 |
T13353 |
T13350 |
relcl |
delete,Variants |
R8620 |
T13354 |
T13353 |
advmod |
functionally,delete |
R8621 |
T13355 |
T13356 |
nmod |
exons,2 |
R8622 |
T13356 |
T13353 |
dobj |
2,delete |
R8623 |
T13357 |
T13356 |
cc |
and,2 |
R8624 |
T13358 |
T13357 |
punct |
/,and |
R8625 |
T13359 |
T13357 |
cc |
or,and |
R8626 |
T13360 |
T13356 |
conj |
3,2 |
R8627 |
T13361 |
T13350 |
punct |
", ",Variants |
R8628 |
T13362 |
T13363 |
amod |
such,as |
R8629 |
T13363 |
T13350 |
prep |
as,Variants |
R8630 |
T13364 |
T13365 |
compound |
variant,C |
R8631 |
T13365 |
T13363 |
pobj |
C,as |
R8632 |
T13366 |
T13367 |
punct |
(,lane |
R8633 |
T13367 |
T13365 |
parataxis |
lane,C |
R8634 |
T13368 |
T13367 |
nummod |
15,lane |
R8635 |
T13369 |
T13367 |
punct |
),lane |
R8636 |
T13370 |
T13351 |
advmod |
also,remove |
R8637 |
T13371 |
T13372 |
det |
the,signals |
R8638 |
T13372 |
T13351 |
dobj |
signals,remove |
R8639 |
T13373 |
T13372 |
amod |
predicted,signals |
R8640 |
T13374 |
T13375 |
amod |
nuclear,localization |
R8641 |
T13375 |
T13372 |
compound |
localization,signals |
R8642 |
T13376 |
T13372 |
punct |
", ",signals |
R8643 |
T13377 |
T13372 |
cc |
and,signals |
R8644 |
T13378 |
T13379 |
det |
the,domains |
R8645 |
T13379 |
T13372 |
conj |
domains,signals |
R8646 |
T13380 |
T13379 |
compound |
binding,domains |
R8647 |
T13381 |
T13379 |
prep |
for,domains |
R8648 |
T13382 |
T13381 |
pobj |
GAS41,for |
R8649 |
T13383 |
T13382 |
cc |
and,GAS41 |
R8650 |
T13384 |
T13382 |
conj |
PCTAIRE2BP,GAS41 |
R8651 |
T13385 |
T13351 |
punct |
.,remove |
R8652 |
T13387 |
T13388 |
det |
These,variants |
R8653 |
T13388 |
T13389 |
nsubj |
variants,retain |
R8654 |
T13390 |
T13389 |
aux |
would,retain |
R8655 |
T13391 |
T13392 |
det |
the,domain |
R8656 |
T13392 |
T13389 |
dobj |
domain,retain |
R8657 |
T13393 |
T13392 |
compound |
TACC,domain |
R8658 |
T13394 |
T13392 |
punct |
", ",domain |
R8659 |
T13395 |
T13392 |
cc |
and,domain |
R8660 |
T13396 |
T13397 |
advmod |
therefore,potential |
R8661 |
T13397 |
T13392 |
conj |
potential,domain |
R8662 |
T13398 |
T13397 |
det |
the,potential |
R8663 |
T13399 |
T13400 |
aux |
to,bind |
R8664 |
T13400 |
T13397 |
acl |
bind,potential |
R8665 |
T13401 |
T13400 |
prep |
to,bind |
R8666 |
T13402 |
T13403 |
compound |
ch,TOG |
R8667 |
T13403 |
T13401 |
pobj |
TOG,to |
R8668 |
T13404 |
T13403 |
punct |
-,TOG |
R8669 |
T13405 |
T13403 |
cc |
and,TOG |
R8670 |
T13406 |
T13407 |
compound |
Aurora,A |
R8671 |
T13407 |
T13408 |
compound |
A,kinase |
R8672 |
T13408 |
T13403 |
conj |
kinase,TOG |
R8673 |
T13409 |
T13400 |
prep |
in,bind |
R8674 |
T13410 |
T13411 |
det |
the,centrosome |
R8675 |
T13411 |
T13409 |
pobj |
centrosome,in |
R8676 |
T13412 |
T13389 |
punct |
.,retain |
R8677 |
T13414 |
T13415 |
dep |
Lane,X1R |
R8678 |
T13415 |
T13420 |
dep |
X1R,ladder |
R8679 |
T13416 |
T13414 |
nummod |
1,Lane |
R8680 |
T13417 |
T13415 |
punct |
: ,X1R |
R8681 |
T13418 |
T13415 |
compound |
EF,X1R |
R8682 |
T13419 |
T13415 |
punct |
/,X1R |
R8683 |
T13421 |
T13420 |
punct |
", ",ladder |
R8684 |
T13422 |
T13423 |
dep |
Lane,BX647R |
R8685 |
T13423 |
T13420 |
dep |
BX647R,ladder |
R8686 |
T13424 |
T13422 |
nummod |
2,Lane |
R8687 |
T13425 |
T13423 |
punct |
: ,BX647R |
R8688 |
T13426 |
T13423 |
compound |
EF,BX647R |
R8689 |
T13427 |
T13423 |
punct |
/,BX647R |
R8690 |
T13428 |
T13420 |
punct |
", ",ladder |
R8691 |
T13429 |
T13430 |
dep |
Lane,6SPR |
R8692 |
T13430 |
T13420 |
dep |
6SPR,ladder |
R8693 |
T13431 |
T13429 |
nummod |
3,Lane |
R8694 |
T13432 |
T13430 |
punct |
: ,6SPR |
R8695 |
T13433 |
T13430 |
compound |
EF,6SPR |
R8696 |
T13434 |
T13430 |
punct |
/,6SPR |
R8697 |
T13435 |
T13420 |
punct |
", ",ladder |
R8698 |
T13436 |
T13437 |
dep |
Lane,1DR |
R8699 |
T13437 |
T13420 |
dep |
1DR,ladder |
R8700 |
T13438 |
T13436 |
nummod |
4,Lane |
R8701 |
T13439 |
T13437 |
punct |
: ,1DR |
R8702 |
T13440 |
T13437 |
compound |
EF,1DR |
R8703 |
T13441 |
T13437 |
punct |
/,1DR |
R8704 |
T13442 |
T13420 |
punct |
", ",ladder |
R8705 |
T13443 |
T13444 |
dep |
Lane,128R |
R8706 |
T13444 |
T13420 |
dep |
128R,ladder |
R8707 |
T13445 |
T13443 |
nummod |
5,Lane |
R8708 |
T13446 |
T13444 |
punct |
", ",128R |
R8709 |
T13447 |
T13444 |
compound |
EF,128R |
R8710 |
T13448 |
T13444 |
punct |
/,128R |
R8711 |
T13449 |
T13420 |
punct |
", ",ladder |
R8712 |
T13450 |
T13451 |
dep |
Lane,X1R |
R8713 |
T13451 |
T13420 |
dep |
X1R,ladder |
R8714 |
T13452 |
T13450 |
nummod |
6,Lane |
R8715 |
T13453 |
T13451 |
compound |
X3F,X1R |
R8716 |
T13454 |
T13451 |
punct |
/,X1R |
R8717 |
T13455 |
T13420 |
punct |
", ",ladder |
R8718 |
T13456 |
T13457 |
dep |
Lane,BX647R |
R8719 |
T13457 |
T13420 |
dep |
BX647R,ladder |
R8720 |
T13458 |
T13456 |
nummod |
7,Lane |
R8721 |
T13459 |
T13457 |
punct |
: ,BX647R |
R8722 |
T13460 |
T13457 |
compound |
X3F,BX647R |
R8723 |
T13461 |
T13457 |
punct |
/,BX647R |
R8724 |
T13462 |
T13420 |
punct |
", ",ladder |
R8725 |
T13463 |
T13464 |
dep |
Lane,6SPR |
R8726 |
T13464 |
T13420 |
dep |
6SPR,ladder |
R8727 |
T13465 |
T13463 |
nummod |
8,Lane |
R8728 |
T13466 |
T13464 |
punct |
: ,6SPR |
R8729 |
T13467 |
T13464 |
compound |
X3F,6SPR |
R8730 |
T13468 |
T13464 |
punct |
/,6SPR |
R8731 |
T13469 |
T13420 |
punct |
", ",ladder |
R8732 |
T13470 |
T13471 |
dep |
Lane,1DR |
R8733 |
T13471 |
T13420 |
dep |
1DR,ladder |
R8734 |
T13472 |
T13470 |
nummod |
9,Lane |
R8735 |
T13473 |
T13471 |
punct |
: ,1DR |
R8736 |
T13474 |
T13471 |
compound |
X3F,1DR |
R8737 |
T13475 |
T13471 |
punct |
/,1DR |
R8738 |
T13476 |
T13420 |
punct |
", ",ladder |
R8739 |
T13477 |
T13478 |
dep |
Lane,128R |
R8740 |
T13478 |
T13420 |
dep |
128R,ladder |
R8741 |
T13479 |
T13477 |
nummod |
10,Lane |
R8742 |
T13480 |
T13478 |
punct |
", ",128R |
R8743 |
T13481 |
T13478 |
compound |
X3F,128R |
R8744 |
T13482 |
T13478 |
punct |
/,128R |
R8745 |
T13483 |
T13420 |
punct |
", ",ladder |
R8746 |
T13484 |
T13485 |
dep |
Lane,X1R |
R8747 |
T13485 |
T13420 |
dep |
X1R,ladder |
R8748 |
T13486 |
T13484 |
nummod |
11,Lane |
R8749 |
T13487 |
T13485 |
punct |
: ,X1R |
R8750 |
T13488 |
T13485 |
compound |
1DF,X1R |
R8751 |
T13489 |
T13485 |
punct |
/,X1R |
R8752 |
T13490 |
T13420 |
punct |
", ",ladder |
R8753 |
T13491 |
T13492 |
dep |
Lane,BX647R |
R8754 |
T13492 |
T13420 |
dep |
BX647R,ladder |
R8755 |
T13493 |
T13491 |
nummod |
12,Lane |
R8756 |
T13494 |
T13492 |
punct |
: ,BX647R |
R8757 |
T13495 |
T13492 |
compound |
1DF,BX647R |
R8758 |
T13496 |
T13492 |
punct |
/,BX647R |
R8759 |
T13497 |
T13420 |
punct |
", ",ladder |
R8760 |
T13498 |
T13499 |
dep |
Lane,6SPR |
R8761 |
T13499 |
T13420 |
dep |
6SPR,ladder |
R8762 |
T13500 |
T13498 |
nummod |
13,Lane |
R8763 |
T13501 |
T13499 |
punct |
: ,6SPR |
R8764 |
T13502 |
T13499 |
compound |
1DF,6SPR |
R8765 |
T13503 |
T13499 |
punct |
/,6SPR |
R8766 |
T13504 |
T13420 |
punct |
", ",ladder |
R8767 |
T13505 |
T13506 |
dep |
Lane,1DR |
R8768 |
T13506 |
T13420 |
dep |
1DR,ladder |
R8769 |
T13507 |
T13505 |
nummod |
14,Lane |
R8770 |
T13508 |
T13506 |
punct |
: ,1DR |
R8771 |
T13509 |
T13506 |
compound |
1DF,1DR |
R8772 |
T13510 |
T13506 |
punct |
/,1DR |
R8773 |
T13511 |
T13420 |
punct |
", ",ladder |
R8774 |
T13512 |
T13513 |
dep |
Lane,128R |
R8775 |
T13513 |
T13420 |
dep |
128R,ladder |
R8776 |
T13514 |
T13512 |
nummod |
15,Lane |
R8777 |
T13515 |
T13513 |
punct |
: ,128R |
R8778 |
T13516 |
T13513 |
compound |
1DF,128R |
R8779 |
T13517 |
T13513 |
punct |
/,128R |
R8780 |
T13518 |
T13420 |
punct |
", ",ladder |
R8781 |
T13519 |
T13420 |
dep |
Lane,ladder |
R8782 |
T13520 |
T13519 |
nummod |
16,Lane |
R8783 |
T13521 |
T13420 |
punct |
: ,ladder |
R8784 |
T13522 |
T13420 |
nmod |
Biorad,ladder |
R8785 |
T13523 |
T13524 |
nummod |
1,kb+ |
R8786 |
T13524 |
T13525 |
compound |
kb+,Size |
R8787 |
T13525 |
T13420 |
compound |
Size,ladder |
R8788 |
T13526 |
T13420 |
punct |
.,ladder |
R4064 |
T6381 |
T6382 |
amod |
Alternative,splicing |
R4065 |
T6383 |
T6382 |
prep |
in,splicing |
R4066 |
T6384 |
T6385 |
compound |
vertebrate,genes |
R4067 |
T6385 |
T6383 |
pobj |
genes,in |
R4068 |
T6386 |
T6385 |
compound |
TACC,genes |
R4069 |
T6388 |
T6389 |
mark |
Whereas,drive |
R4070 |
T6389 |
T6393 |
advcl |
drive,give |
R4071 |
T6390 |
T6391 |
compound |
exon,shuffling |
R4072 |
T6391 |
T6389 |
nsubj |
shuffling,drive |
R4073 |
T6392 |
T6389 |
aux |
can,drive |
R4074 |
T6394 |
T6395 |
det |
the,diversification |
R4075 |
T6395 |
T6389 |
dobj |
diversification,drive |
R4076 |
T6396 |
T6395 |
amod |
functional,diversification |
R4077 |
T6397 |
T6395 |
prep |
of,diversification |
R4078 |
T6398 |
T6399 |
compound |
gene,families |
R4079 |
T6399 |
T6397 |
pobj |
families,of |
R4080 |
T6400 |
T6389 |
prep |
over,drive |
R4081 |
T6401 |
T6402 |
amod |
evolutionary,time |
R4082 |
T6402 |
T6400 |
pobj |
time,over |
R4083 |
T6403 |
T6393 |
punct |
", ",give |
R4084 |
T6404 |
T6405 |
det |
the,splicing |
R4085 |
T6405 |
T6393 |
nsubj |
splicing,give |
R4086 |
T6406 |
T6405 |
amod |
temporal,splicing |
R4087 |
T6407 |
T6406 |
cc |
and,temporal |
R4088 |
T6408 |
T6407 |
punct |
/,and |
R4089 |
T6409 |
T6407 |
cc |
or,and |
R4090 |
T6410 |
T6411 |
npadvmod |
tissue,specific |
R4091 |
T6411 |
T6406 |
conj |
specific,temporal |
R4092 |
T6412 |
T6405 |
amod |
alternative,splicing |
R4093 |
T6413 |
T6405 |
prep |
of,splicing |
R4094 |
T6414 |
T6415 |
det |
a,gene |
R4095 |
T6415 |
T6413 |
pobj |
gene,of |
R4096 |
T6416 |
T6393 |
aux |
can,give |
R4097 |
T6417 |
T6393 |
dobj |
rise,give |
R4098 |
T6418 |
T6393 |
prep |
to,give |
R4099 |
T6419 |
T6420 |
amod |
functional,diversification |
R4100 |
T6420 |
T6418 |
pobj |
diversification,to |
R4101 |
T6421 |
T6420 |
prep |
of,diversification |
R4102 |
T6422 |
T6423 |
det |
a,gene |
R4103 |
T6423 |
T6421 |
pobj |
gene,of |
R4104 |
T6424 |
T6423 |
amod |
single,gene |
R4105 |
T6425 |
T6393 |
prep |
during,give |
R4106 |
T6426 |
T6427 |
det |
the,development |
R4107 |
T6427 |
T6425 |
pobj |
development,during |
R4108 |
T6428 |
T6427 |
prep |
of,development |
R4109 |
T6429 |
T6430 |
det |
an,organism |
R4110 |
T6430 |
T6428 |
pobj |
organism,of |
R4111 |
T6431 |
T6393 |
punct |
.,give |
R4112 |
T6433 |
T6434 |
mark |
Although,documented |
R4113 |
T6434 |
T6443 |
advcl |
documented,observed |
R4114 |
T6435 |
T6436 |
det |
no,splicing |
R4115 |
T6436 |
T6434 |
nsubjpass |
splicing,documented |
R4116 |
T6437 |
T6436 |
amod |
alternative,splicing |
R4117 |
T6438 |
T6436 |
prep |
of,splicing |
R4118 |
T6439 |
T6438 |
pobj |
TACC3,of |
R4119 |
T6440 |
T6434 |
aux |
has,documented |
R4120 |
T6441 |
T6434 |
auxpass |
been,documented |
R4121 |
T6442 |
T6434 |
advmod |
clearly,documented |
R4122 |
T6444 |
T6443 |
punct |
", ",observed |
R4123 |
T6445 |
T6446 |
preconj |
both,temporal |
R4124 |
T6446 |
T6447 |
amod |
temporal,splicing |
R4125 |
T6447 |
T6443 |
nsubjpass |
splicing,observed |
R4126 |
T6448 |
T6446 |
cc |
and,temporal |
R4127 |
T6449 |
T6450 |
npadvmod |
tissue,specific |
R4128 |
T6450 |
T6446 |
conj |
specific,temporal |
R4129 |
T6451 |
T6443 |
auxpass |
is,observed |
R4130 |
T6452 |
T6443 |
prep |
in,observed |
R4131 |
T6453 |
T6454 |
det |
the,genes |
R4132 |
T6454 |
T6452 |
pobj |
genes,in |
R4133 |
T6455 |
T6454 |
nmod |
TACC1,genes |
R4134 |
T6456 |
T6455 |
cc |
and,TACC1 |
R4135 |
T6457 |
T6455 |
conj |
TACC2,TACC1 |
R4136 |
T6458 |
T6443 |
punct |
.,observed |
R4137 |
T6460 |
T6461 |
prep |
In,accounts |
R4138 |
T6462 |
T6463 |
det |
the,case |
R4139 |
T6463 |
T6460 |
pobj |
case,In |
R4140 |
T6464 |
T6463 |
prep |
of,case |
R4141 |
T6465 |
T6464 |
pobj |
TACC2,of |
R4142 |
T6466 |
T6461 |
punct |
", ",accounts |
R4143 |
T6467 |
T6468 |
det |
an,exon |
R4144 |
T6468 |
T6461 |
nsubj |
exon,accounts |
R4145 |
T6469 |
T6468 |
amod |
additional,exon |
R4146 |
T6470 |
T6468 |
amod |
large,exon |
R4147 |
T6471 |
T6472 |
punct |
(,kb |
R4148 |
T6472 |
T6470 |
parataxis |
kb,large |
R4149 |
T6473 |
T6472 |
nummod |
5,kb |
R4150 |
T6474 |
T6472 |
punct |
),kb |
R4151 |
T6475 |
T6461 |
prep |
for,accounts |
R4152 |
T6476 |
T6477 |
det |
the,difference |
R4153 |
T6477 |
T6475 |
pobj |
difference,for |
R4154 |
T6478 |
T6477 |
amod |
main,difference |
R4155 |
T6479 |
T6477 |
prep |
between,difference |
R4156 |
T6480 |
T6481 |
det |
the,variants |
R4157 |
T6481 |
T6479 |
pobj |
variants,between |
R4158 |
T6482 |
T6481 |
amod |
major,variants |
R4159 |
T6483 |
T6481 |
compound |
splice,variants |
R4160 |
T6484 |
T6481 |
prep |
of,variants |
R4161 |
T6485 |
T6486 |
det |
the,genes |
R4162 |
T6486 |
T6484 |
pobj |
genes,of |
R4163 |
T6487 |
T6486 |
compound |
vertebrate,genes |
R4164 |
T6488 |
T6486 |
compound |
TACC2,genes |
R4165 |
T6489 |
T6490 |
punct |
[,3 |
R4166 |
T6490 |
T6461 |
parataxis |
3,accounts |
R4167 |
T6491 |
T6490 |
punct |
],3 |
R4168 |
T6492 |
T6461 |
punct |
.,accounts |
R4169 |
T6494 |
T6495 |
det |
The,splicing |
R4170 |
T6495 |
T6497 |
nsubj |
splicing,suggests |
R4171 |
T6496 |
T6495 |
amod |
alternative,splicing |
R4172 |
T6498 |
T6495 |
prep |
of,splicing |
R4173 |
T6499 |
T6500 |
det |
this,exon |
R4174 |
T6500 |
T6498 |
pobj |
exon,of |
R4175 |
T6501 |
T6502 |
det |
a,difference |
R4176 |
T6502 |
T6497 |
dobj |
difference,suggests |
R4177 |
T6503 |
T6502 |
amod |
major,difference |
R4178 |
T6504 |
T6502 |
amod |
functional,difference |
R4179 |
T6505 |
T6502 |
prep |
between,difference |
R4180 |
T6506 |
T6507 |
det |
the,isoforms |
R4181 |
T6507 |
T6505 |
pobj |
isoforms,between |
R4182 |
T6508 |
T6507 |
nummod |
two,isoforms |
R4183 |
T6509 |
T6507 |
compound |
TACC2,isoforms |
R4184 |
T6510 |
T6507 |
punct |
", ",isoforms |
R4185 |
T6511 |
T6507 |
appos |
TACC2s,isoforms |
R4186 |
T6512 |
T6511 |
cc |
and,TACC2s |
R4187 |
T6513 |
T6511 |
conj |
TACC2l,TACC2s |
R4188 |
T6514 |
T6515 |
punct |
[,3 |
R4189 |
T6515 |
T6502 |
parataxis |
3,difference |
R4190 |
T6516 |
T6515 |
punct |
],3 |
R4191 |
T6517 |
T6502 |
punct |
", ",difference |
R4192 |
T6518 |
T6519 |
advmod |
as,as |
R4193 |
T6519 |
T6502 |
cc |
as,difference |
R4194 |
T6520 |
T6519 |
advmod |
well,as |
R4195 |
T6521 |
T6522 |
det |
a,difference |
R4196 |
T6522 |
T6502 |
conj |
difference,difference |
R4197 |
T6523 |
T6522 |
amod |
significant,difference |
R4198 |
T6524 |
T6522 |
prep |
between,difference |
R4199 |
T6525 |
T6524 |
pobj |
TACC2,between |
R4200 |
T6526 |
T6525 |
cc |
and,TACC2 |
R4201 |
T6527 |
T6528 |
poss |
its,relative |
R4202 |
T6528 |
T6525 |
conj |
relative,TACC2 |
R4203 |
T6529 |
T6528 |
amod |
closest,relative |
R4204 |
T6530 |
T6531 |
compound |
TACC,family |
R4205 |
T6531 |
T6528 |
compound |
family,relative |
R4206 |
T6532 |
T6528 |
punct |
", ",relative |
R4207 |
T6533 |
T6528 |
appos |
TACC1,relative |
R4208 |
T6534 |
T6497 |
punct |
.,suggests |
R4209 |
T6536 |
T6537 |
advmod |
However,is |
R4210 |
T6538 |
T6537 |
punct |
", ",is |
R4211 |
T6539 |
T6540 |
det |
the,function |
R4212 |
T6540 |
T6537 |
nsubj |
function,is |
R4213 |
T6541 |
T6540 |
prep |
of,function |
R4214 |
T6542 |
T6543 |
det |
this,region |
R4215 |
T6543 |
T6541 |
pobj |
region,of |
R4216 |
T6544 |
T6543 |
prep |
of,region |
R4217 |
T6545 |
T6546 |
det |
the,isoform |
R4218 |
T6546 |
T6544 |
pobj |
isoform,of |
R4219 |
T6547 |
T6546 |
compound |
TACC2l,isoform |
R4220 |
T6548 |
T6537 |
advmod |
current,is |
R4221 |
T6549 |
T6537 |
acomp |
unknown,is |
R4222 |
T6550 |
T6537 |
punct |
.,is |
R4223 |
T6552 |
T6553 |
amod |
Alternative,splicing |
R4224 |
T6553 |
T6554 |
nsubjpass |
splicing,noted |
R4225 |
T6555 |
T6553 |
punct |
", ",splicing |
R4226 |
T6556 |
T6553 |
advmod |
together,splicing |
R4227 |
T6557 |
T6556 |
prep |
with,together |
R4228 |
T6558 |
T6559 |
amod |
differential,usage |
R4229 |
T6559 |
T6557 |
pobj |
usage,with |
R4230 |
T6560 |
T6559 |
compound |
promoter,usage |
R4231 |
T6561 |
T6554 |
aux |
has,noted |
R4232 |
T6562 |
T6554 |
advmod |
already,noted |
R4233 |
T6563 |
T6554 |
auxpass |
been,noted |
R4234 |
T6564 |
T6554 |
prep |
for,noted |
R4235 |
T6565 |
T6566 |
det |
the,gene |
R4236 |
T6566 |
T6564 |
pobj |
gene,for |
R4237 |
T6567 |
T6566 |
amod |
human,gene |
R4238 |
T6568 |
T6566 |
compound |
TACC1,gene |
R4239 |
T6569 |
T6570 |
punct |
[,19 |
R4240 |
T6570 |
T6554 |
parataxis |
19,noted |
R4241 |
T6571 |
T6570 |
nummod |
18,19 |
R4242 |
T6572 |
T6570 |
punct |
",",19 |
R4243 |
T6573 |
T6570 |
punct |
],19 |
R4244 |
T6574 |
T6554 |
punct |
.,noted |
R4245 |
T6576 |
T6577 |
prep |
In,identified |
R4246 |
T6578 |
T6576 |
pobj |
addition,In |
R4247 |
T6579 |
T6577 |
punct |
", ",identified |
R4248 |
T6580 |
T6581 |
mark |
as,shown |
R4249 |
T6581 |
T6577 |
advcl |
shown,identified |
R4250 |
T6582 |
T6581 |
prep |
in,shown |
R4251 |
T6583 |
T6582 |
pobj |
Fig.,in |
R4252 |
T6584 |
T6583 |
nummod |
5,Fig. |
R4253 |
T6585 |
T6577 |
punct |
", ",identified |
R4254 |
T6586 |
T6577 |
nsubj |
we,identified |
R4255 |
T6587 |
T6577 |
aux |
have,identified |
R4256 |
T6588 |
T6589 |
amod |
additional,isoforms |
R4257 |
T6589 |
T6577 |
dobj |
isoforms,identified |
R4258 |
T6590 |
T6589 |
compound |
TACC1,isoforms |
R4259 |
T6591 |
T6592 |
dep |
that,result |
R4260 |
T6592 |
T6589 |
relcl |
result,isoforms |
R4261 |
T6593 |
T6592 |
prep |
from,result |
R4262 |
T6594 |
T6595 |
amod |
alternative,splicing |
R4263 |
T6595 |
T6593 |
pobj |
splicing,from |
R4264 |
T6596 |
T6595 |
prep |
of,splicing |
R4265 |
T6597 |
T6598 |
nmod |
exons,4a |
R4266 |
T6598 |
T6596 |
pobj |
4a,of |
R4267 |
T6599 |
T6598 |
nummod |
1b,4a |
R4268 |
T6600 |
T6598 |
punct |
-,4a |
R4269 |
T6601 |
T6577 |
punct |
.,identified |
R4270 |
T6603 |
T6604 |
det |
The,functions |
R4271 |
T6604 |
T6605 |
nsubj |
functions,are |
R4272 |
T6605 |
T6610 |
ccomp |
are,include |
R4273 |
T6606 |
T6604 |
prep |
of,functions |
R4274 |
T6607 |
T6608 |
det |
these,isoforms |
R4275 |
T6608 |
T6606 |
pobj |
isoforms,of |
R4276 |
T6609 |
T6608 |
amod |
different,isoforms |
R4277 |
T6611 |
T6605 |
acomp |
unknown,are |
R4278 |
T6612 |
T6610 |
punct |
", ",include |
R4279 |
T6613 |
T6610 |
advmod |
however,include |
R4280 |
T6614 |
T6615 |
det |
the,region |
R4281 |
T6615 |
T6610 |
nsubj |
region,include |
R4282 |
T6616 |
T6615 |
acl |
deleted,region |
R4283 |
T6617 |
T6616 |
prep |
from,deleted |
R4284 |
T6618 |
T6619 |
det |
the,variants |
R4285 |
T6619 |
T6617 |
pobj |
variants,from |
R4286 |
T6620 |
T6619 |
amod |
shorter,variants |
R4287 |
T6621 |
T6610 |
aux |
can,include |
R4288 |
T6622 |
T6623 |
det |
the,site |
R4289 |
T6623 |
T6610 |
dobj |
site,include |
R4290 |
T6624 |
T6623 |
compound |
binding,site |
R4291 |
T6625 |
T6623 |
prep |
for,site |
R4292 |
T6626 |
T6625 |
pobj |
LSm7,for |
R4293 |
T6627 |
T6628 |
punct |
[,20 |
R4294 |
T6628 |
T6623 |
parataxis |
20,site |
R4295 |
T6629 |
T6628 |
punct |
],20 |
R4296 |
T6630 |
T6631 |
punct |
(,C |
R4297 |
T6631 |
T6623 |
parataxis |
C,site |
R4298 |
T6632 |
T6631 |
compound |
variants,C |
R4299 |
T6633 |
T6631 |
punct |
", ",C |
R4300 |
T6634 |
T6631 |
appos |
D,C |
R4301 |
T6635 |
T6631 |
punct |
", ",C |
R4302 |
T6636 |
T6631 |
appos |
F,C |
R4303 |
T6637 |
T6638 |
punct |
-,I |
R4304 |
T6638 |
T6636 |
prep |
I,F |
R4305 |
T6639 |
T6631 |
punct |
),C |
R4306 |
T6640 |
T6623 |
punct |
", ",site |
R4307 |
T6641 |
T6623 |
cc |
and,site |
R4308 |
T6642 |
T6641 |
punct |
/,and |
R4309 |
T6643 |
T6641 |
cc |
or,and |
R4310 |
T6644 |
T6645 |
det |
the,signals |
R4311 |
T6645 |
T6623 |
conj |
signals,site |
R4312 |
T6646 |
T6645 |
amod |
nuclear,signals |
R4313 |
T6647 |
T6645 |
compound |
localization,signals |
R4314 |
T6648 |
T6645 |
cc |
and,signals |
R4315 |
T6649 |
T6650 |
compound |
binding,site |
R4316 |
T6650 |
T6645 |
conj |
site,signals |
R4317 |
T6651 |
T6650 |
prep |
for,site |
R4318 |
T6652 |
T6651 |
pobj |
GAS41,for |
R4319 |
T6653 |
T6654 |
punct |
[,15 |
R4320 |
T6654 |
T6650 |
parataxis |
15,site |
R4321 |
T6655 |
T6654 |
punct |
],15 |
R4322 |
T6656 |
T6645 |
cc |
and,signals |
R4323 |
T6657 |
T6645 |
conj |
PCTAIRE2BP,signals |
R4324 |
T6658 |
T6659 |
punct |
[,20 |
R4325 |
T6659 |
T6657 |
parataxis |
20,PCTAIRE2BP |
R4326 |
T6660 |
T6659 |
punct |
],20 |
R4327 |
T6661 |
T6662 |
punct |
(,B |
R4328 |
T6662 |
T6657 |
parataxis |
B,PCTAIRE2BP |
R4329 |
T6663 |
T6662 |
compound |
isoforms,B |
R4330 |
T6664 |
T6665 |
punct |
-,D |
R4331 |
T6665 |
T6662 |
prep |
D,B |
R4332 |
T6666 |
T6662 |
punct |
", ",B |
R4333 |
T6667 |
T6662 |
appos |
S,B |
R4334 |
T6668 |
T6662 |
punct |
),B |
R4335 |
T6669 |
T6610 |
punct |
.,include |
R4336 |
T6671 |
T6672 |
nsubjpass |
One,localized |
R4337 |
T6673 |
T6671 |
prep |
of,One |
R4338 |
T6674 |
T6675 |
det |
these,isoforms |
R4339 |
T6675 |
T6673 |
pobj |
isoforms,of |
R4340 |
T6676 |
T6671 |
punct |
", ",One |
R4341 |
T6677 |
T6671 |
appos |
TACC1S,One |
R4342 |
T6678 |
T6672 |
auxpass |
is,localized |
R4343 |
T6679 |
T6680 |
advmod |
exclusively,to |
R4344 |
T6680 |
T6672 |
prep |
to,localized |
R4345 |
T6681 |
T6682 |
det |
the,cytoplasm |
R4346 |
T6682 |
T6680 |
pobj |
cytoplasm,to |
R4347 |
T6683 |
T6684 |
punct |
[,19 |
R4348 |
T6684 |
T6672 |
parataxis |
19,localized |
R4349 |
T6685 |
T6684 |
punct |
],19 |
R4350 |
T6686 |
T6672 |
punct |
", ",localized |
R4351 |
T6687 |
T6672 |
advcl |
suggesting,localized |
R4352 |
T6688 |
T6689 |
mark |
that,be |
R4353 |
T6689 |
T6687 |
ccomp |
be,suggesting |
R4354 |
T6690 |
T6691 |
det |
the,isoforms |
R4355 |
T6691 |
T6689 |
nsubj |
isoforms,be |
R4356 |
T6692 |
T6691 |
amod |
shorter,isoforms |
R4357 |
T6693 |
T6689 |
aux |
would,be |
R4358 |
T6694 |
T6689 |
neg |
not,be |
R4359 |
T6695 |
T6689 |
acomp |
able,be |
R4360 |
T6696 |
T6697 |
aux |
to,interact |
R4361 |
T6697 |
T6695 |
xcomp |
interact,able |
R4362 |
T6698 |
T6697 |
prep |
with,interact |
R4363 |
T6699 |
T6698 |
pobj |
elements,with |
R4364 |
T6700 |
T6699 |
prep |
of,elements |
R4365 |
T6701 |
T6702 |
det |
the,remodeling |
R4366 |
T6702 |
T6700 |
pobj |
remodeling,of |
R4367 |
T6703 |
T6702 |
compound |
chomatin,remodeling |
R4368 |
T6704 |
T6699 |
cc |
and,elements |
R4369 |
T6705 |
T6704 |
punct |
/,and |
R4370 |
T6706 |
T6704 |
cc |
or,and |
R4371 |
T6707 |
T6708 |
compound |
RNA,machinery |
R4372 |
T6708 |
T6699 |
conj |
machinery,elements |
R4373 |
T6709 |
T6708 |
compound |
processing,machinery |
R4374 |
T6710 |
T6697 |
prep |
in,interact |
R4375 |
T6711 |
T6712 |
det |
the,nucleus |
R4376 |
T6712 |
T6710 |
pobj |
nucleus,in |
R4377 |
T6713 |
T6672 |
punct |
.,localized |
R4378 |
T6715 |
T6716 |
advmod |
Thus,result |
R4379 |
T6717 |
T6716 |
punct |
", ",result |
R4380 |
T6718 |
T6716 |
nsubj |
changes,result |
R4381 |
T6719 |
T6718 |
prep |
in,changes |
R4382 |
T6720 |
T6721 |
det |
the,complement |
R4383 |
T6721 |
T6719 |
pobj |
complement,in |
R4384 |
T6722 |
T6721 |
prep |
of,complement |
R4385 |
T6723 |
T6724 |
compound |
TACC1,isoforms |
R4386 |
T6724 |
T6722 |
pobj |
isoforms,of |
R4387 |
T6725 |
T6718 |
prep |
in,changes |
R4388 |
T6726 |
T6727 |
det |
the,cell |
R4389 |
T6727 |
T6725 |
pobj |
cell,in |
R4390 |
T6728 |
T6716 |
aux |
may,result |
R4391 |
T6729 |
T6716 |
prep |
in,result |
R4392 |
T6730 |
T6729 |
pobj |
alterations,in |
R4393 |
T6731 |
T6730 |
prep |
in,alterations |
R4394 |
T6732 |
T6733 |
amod |
cellular,metabolism |
R4395 |
T6733 |
T6731 |
pobj |
metabolism,in |
R4396 |
T6734 |
T6733 |
compound |
RNA,metabolism |
R4397 |
T6735 |
T6730 |
prep |
at,alterations |
R4398 |
T6736 |
T6737 |
amod |
multiple,levels |
R4399 |
T6737 |
T6735 |
pobj |
levels,at |
R4400 |
T6738 |
T6716 |
punct |
", ",result |
R4401 |
T6739 |
T6716 |
cc |
and,result |
R4402 |
T6740 |
T6741 |
aux |
may,account |
R4403 |
T6741 |
T6716 |
conj |
account,result |
R4404 |
T6742 |
T6741 |
prep |
for,account |
R4405 |
T6743 |
T6744 |
det |
the,observation |
R4406 |
T6744 |
T6742 |
pobj |
observation,for |
R4407 |
T6745 |
T6746 |
mark |
that,associated |
R4408 |
T6746 |
T6744 |
acl |
associated,observation |
R4409 |
T6747 |
T6748 |
nmod |
TACC1D,isoforms |
R4410 |
T6748 |
T6746 |
nsubjpass |
isoforms,associated |
R4411 |
T6749 |
T6747 |
cc |
and,TACC1D |
R4412 |
T6750 |
T6747 |
conj |
TACC1F,TACC1D |
R4413 |
T6751 |
T6746 |
auxpass |
are,associated |
R4414 |
T6752 |
T6746 |
prep |
with,associated |
R4415 |
T6753 |
T6754 |
amod |
tumorigenic,changes |
R4416 |
T6754 |
T6752 |
pobj |
changes,with |
R4417 |
T6755 |
T6746 |
prep |
in,associated |
R4418 |
T6756 |
T6757 |
amod |
gastric,mucosa |
R4419 |
T6757 |
T6755 |
pobj |
mucosa,in |
R4420 |
T6758 |
T6759 |
punct |
[,18 |
R4421 |
T6759 |
T6744 |
parataxis |
18,observation |
R4422 |
T6760 |
T6759 |
punct |
],18 |
R4423 |
T6761 |
T6716 |
punct |
.,result |