PMC:441373 / 23694-25481 JSONTXT

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The majority of this central portion, which contains the SDP repeat motifs, is encoded by one exon in human and the pufferfish (emb|CAAB01001184). In rodents, however, this region is almost entirely composed of seven 24 amino acid repeats, which are located in a single exon of the mouse and rat TACC3 genes. It has been previously reported that there are four mouse TACC3 splice variants that differ in the number of these repeats [2,7,17]. As these repeats are present in a single exon, it appears likely that these different sequences may be the result of the DNA polymerases used in the cDNA synthesis and/or PCR reaction stuttering through the repeat motif. The correct sequence, reported by Sadek et al [7], is the one used throughout the entirety of this manuscript. 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