Id |
Subject |
Object |
Predicate |
Lexical cue |
T194 |
0-10 |
NN |
denotes |
Background |
T195 |
10-135 |
sentence |
denotes |
Examination of ancient gene families can provide an insight into how the evolution of gene structure can relate to function. |
T196 |
11-22 |
NN |
denotes |
Examination |
T197 |
52-59 |
VB |
denotes |
provide |
T198 |
23-25 |
IN |
denotes |
of |
T199 |
26-33 |
JJ |
denotes |
ancient |
T200 |
39-47 |
NNS |
denotes |
families |
T201 |
34-38 |
NN |
denotes |
gene |
T202 |
48-51 |
MD |
denotes |
can |
T203 |
60-62 |
DT |
denotes |
an |
T204 |
63-70 |
NN |
denotes |
insight |
T205 |
71-75 |
IN |
denotes |
into |
T206 |
76-79 |
WRB |
denotes |
how |
T207 |
116-122 |
VB |
denotes |
relate |
T208 |
80-83 |
DT |
denotes |
the |
T209 |
84-93 |
NN |
denotes |
evolution |
T210 |
94-96 |
IN |
denotes |
of |
T211 |
97-101 |
NN |
denotes |
gene |
T212 |
102-111 |
NN |
denotes |
structure |
T213 |
112-115 |
MD |
denotes |
can |
T214 |
123-125 |
IN |
denotes |
to |
T215 |
126-134 |
NN |
denotes |
function |
T216 |
134-135 |
. |
denotes |
. |
T217 |
135-282 |
sentence |
denotes |
Functional homologs of the evolutionarily conserved transforming acidic coiled coil (TACC) gene family are present in organisms from yeast to man. |
T218 |
136-146 |
JJ |
denotes |
Functional |
T219 |
147-155 |
NNS |
denotes |
homologs |
T220 |
239-242 |
VBP |
denotes |
are |
T221 |
156-158 |
IN |
denotes |
of |
T222 |
159-162 |
DT |
denotes |
the |
T223 |
232-238 |
NN |
denotes |
family |
T224 |
163-177 |
RB |
denotes |
evolutionarily |
T225 |
178-187 |
VBN |
denotes |
conserved |
T226 |
188-200 |
VBG |
denotes |
transforming |
T227 |
215-219 |
NN |
denotes |
coil |
T228 |
201-207 |
JJ |
denotes |
acidic |
T229 |
208-214 |
VBN |
denotes |
coiled |
T230 |
220-221 |
-LRB- |
denotes |
( |
T231 |
221-225 |
NN |
denotes |
TACC |
T232 |
225-226 |
-RRB- |
denotes |
) |
T233 |
227-231 |
NN |
denotes |
gene |
T234 |
243-250 |
JJ |
denotes |
present |
T235 |
251-253 |
IN |
denotes |
in |
T236 |
254-263 |
NNS |
denotes |
organisms |
T237 |
264-268 |
IN |
denotes |
from |
T238 |
269-274 |
NN |
denotes |
yeast |
T239 |
275-277 |
IN |
denotes |
to |
T240 |
278-281 |
NN |
denotes |
man |
T241 |
281-282 |
. |
denotes |
. |
T242 |
282-399 |
sentence |
denotes |
However, correlations between functional interactions and the evolution of these proteins have yet to be determined. |
T243 |
283-290 |
RB |
denotes |
However |
T244 |
373-377 |
VBP |
denotes |
have |
T245 |
290-292 |
, |
denotes |
, |
T246 |
292-304 |
NNS |
denotes |
correlations |
T247 |
305-312 |
IN |
denotes |
between |
T248 |
313-323 |
JJ |
denotes |
functional |
T249 |
324-336 |
NNS |
denotes |
interactions |
T250 |
337-340 |
CC |
denotes |
and |
T251 |
341-344 |
DT |
denotes |
the |
T252 |
345-354 |
NN |
denotes |
evolution |
T253 |
355-357 |
IN |
denotes |
of |
T254 |
358-363 |
DT |
denotes |
these |
T255 |
364-372 |
NN |
denotes |
proteins |
T256 |
378-381 |
RB |
denotes |
yet |
T257 |
388-398 |
VBN |
denotes |
determined |
T258 |
382-384 |
TO |
denotes |
to |
T259 |
385-387 |
VB |
denotes |
be |
T260 |
398-399 |
. |
denotes |
. |
T261 |
399-408 |
sentence |
denotes |
Results |
T262 |
401-408 |
NNS |
denotes |
Results |
T263 |
408-555 |
sentence |
denotes |
We have performed an extensive database analysis to determine the genomic and cDNA sequences of the TACCs from phylogenetically diverse organisms. |
T264 |
409-411 |
PRP |
denotes |
We |
T265 |
417-426 |
VBN |
denotes |
performed |
T266 |
412-416 |
VBP |
denotes |
have |
T267 |
427-429 |
DT |
denotes |
an |
T268 |
449-457 |
NN |
denotes |
analysis |
T269 |
430-439 |
JJ |
denotes |
extensive |
T270 |
440-448 |
NN |
denotes |
database |
T271 |
458-460 |
TO |
denotes |
to |
T272 |
461-470 |
VB |
denotes |
determine |
T273 |
471-474 |
DT |
denotes |
the |
T274 |
492-501 |
NNS |
denotes |
sequences |
T275 |
475-482 |
JJ |
denotes |
genomic |
T276 |
483-486 |
CC |
denotes |
and |
T277 |
487-491 |
NN |
denotes |
cDNA |
T278 |
502-504 |
IN |
denotes |
of |
T279 |
505-508 |
DT |
denotes |
the |
T280 |
509-514 |
NNS |
denotes |
TACCs |
T281 |
515-519 |
IN |
denotes |
from |
T282 |
520-536 |
RB |
denotes |
phylogenetically |
T283 |
537-544 |
JJ |
denotes |
diverse |
T284 |
545-554 |
NNS |
denotes |
organisms |
T285 |
554-555 |
. |
denotes |
. |
T286 |
555-808 |
sentence |
denotes |
This analysis has determined the phylogenetic relationship of the TACC proteins to other coiled coil proteins, the resolution of the placement of the rabbit TACC4 as the orthologue of human TACC3, and RHAMM as a distinct family of coiled coil proteins. |
T287 |
556-560 |
DT |
denotes |
This |
T288 |
561-569 |
NN |
denotes |
analysis |
T289 |
574-584 |
VBN |
denotes |
determined |
T290 |
570-573 |
VBZ |
denotes |
has |
T291 |
585-588 |
DT |
denotes |
the |
T292 |
602-614 |
NN |
denotes |
relationship |
T293 |
589-601 |
JJ |
denotes |
phylogenetic |
T294 |
615-617 |
IN |
denotes |
of |
T295 |
618-621 |
DT |
denotes |
the |
T296 |
627-635 |
NN |
denotes |
proteins |
T297 |
622-626 |
NN |
denotes |
TACC |
T298 |
636-638 |
IN |
denotes |
to |
T299 |
639-644 |
JJ |
denotes |
other |
T300 |
657-665 |
NN |
denotes |
proteins |
T301 |
645-651 |
VBN |
denotes |
coiled |
T302 |
652-656 |
NN |
denotes |
coil |
T303 |
665-667 |
, |
denotes |
, |
T304 |
667-670 |
DT |
denotes |
the |
T305 |
671-681 |
NN |
denotes |
resolution |
T306 |
682-684 |
IN |
denotes |
of |
T307 |
685-688 |
DT |
denotes |
the |
T308 |
689-698 |
NN |
denotes |
placement |
T309 |
699-701 |
IN |
denotes |
of |
T310 |
702-705 |
DT |
denotes |
the |
T311 |
713-718 |
NN |
denotes |
TACC4 |
T312 |
706-712 |
NN |
denotes |
rabbit |
T313 |
719-721 |
IN |
denotes |
as |
T314 |
722-725 |
DT |
denotes |
the |
T315 |
726-736 |
NN |
denotes |
orthologue |
T316 |
737-739 |
IN |
denotes |
of |
T317 |
740-745 |
JJ |
denotes |
human |
T318 |
746-751 |
NN |
denotes |
TACC3 |
T319 |
751-753 |
, |
denotes |
, |
T320 |
753-756 |
CC |
denotes |
and |
T321 |
757-762 |
NN |
denotes |
RHAMM |
T322 |
763-765 |
IN |
denotes |
as |
T323 |
766-767 |
DT |
denotes |
a |
T324 |
777-783 |
NN |
denotes |
family |
T325 |
768-776 |
JJ |
denotes |
distinct |
T326 |
784-786 |
IN |
denotes |
of |
T327 |
787-793 |
VBN |
denotes |
coiled |
T328 |
794-798 |
NN |
denotes |
coil |
T329 |
799-807 |
NN |
denotes |
proteins |
T330 |
807-808 |
. |
denotes |
. |
T331 |
808-968 |
sentence |
denotes |
We have also extended the analysis of the TACCs to the interaction databases of C. elegans and D. melanogaster to identify potentially novel TACC interactions. |
T332 |
809-811 |
PRP |
denotes |
We |
T333 |
822-830 |
VBN |
denotes |
extended |
T334 |
812-816 |
VBP |
denotes |
have |
T335 |
817-821 |
RB |
denotes |
also |
T336 |
831-834 |
DT |
denotes |
the |
T337 |
835-843 |
NN |
denotes |
analysis |
T338 |
844-846 |
IN |
denotes |
of |
T339 |
847-850 |
DT |
denotes |
the |
T340 |
851-856 |
NNS |
denotes |
TACCs |
T341 |
857-859 |
IN |
denotes |
to |
T342 |
860-863 |
DT |
denotes |
the |
T343 |
876-885 |
NNS |
denotes |
databases |
T344 |
864-875 |
NN |
denotes |
interaction |
T345 |
886-888 |
IN |
denotes |
of |
T346 |
889-891 |
NNP |
denotes |
C. |
T347 |
892-899 |
NNP |
denotes |
elegans |
T348 |
900-903 |
CC |
denotes |
and |
T349 |
904-906 |
NNP |
denotes |
D. |
T350 |
907-919 |
NNP |
denotes |
melanogaster |
T351 |
920-922 |
TO |
denotes |
to |
T352 |
923-931 |
VB |
denotes |
identify |
T353 |
932-943 |
RB |
denotes |
potentially |
T354 |
944-949 |
JJ |
denotes |
novel |
T355 |
955-967 |
NNS |
denotes |
interactions |
T356 |
950-954 |
NN |
denotes |
TACC |
T357 |
967-968 |
. |
denotes |
. |
T358 |
968-1118 |
sentence |
denotes |
The validity of this modeling was confirmed independently by the demonstration of direct binding of human TACC2 to the nuclear hormone receptor RXRβ. |
T359 |
969-972 |
DT |
denotes |
The |
T360 |
973-981 |
NN |
denotes |
validity |
T361 |
1003-1012 |
VBN |
denotes |
confirmed |
T362 |
982-984 |
IN |
denotes |
of |
T363 |
985-989 |
DT |
denotes |
this |
T364 |
990-998 |
NN |
denotes |
modeling |
T365 |
999-1002 |
VBD |
denotes |
was |
T366 |
1013-1026 |
RB |
denotes |
independently |
T367 |
1027-1029 |
IN |
denotes |
by |
T368 |
1030-1033 |
DT |
denotes |
the |
T369 |
1034-1047 |
NN |
denotes |
demonstration |
T370 |
1048-1050 |
IN |
denotes |
of |
T371 |
1051-1057 |
JJ |
denotes |
direct |
T372 |
1058-1065 |
NN |
denotes |
binding |
T373 |
1066-1068 |
IN |
denotes |
of |
T374 |
1069-1074 |
JJ |
denotes |
human |
T375 |
1075-1080 |
NN |
denotes |
TACC2 |
T376 |
1081-1083 |
IN |
denotes |
to |
T377 |
1084-1087 |
DT |
denotes |
the |
T378 |
1104-1112 |
NN |
denotes |
receptor |
T379 |
1088-1095 |
JJ |
denotes |
nuclear |
T380 |
1096-1103 |
NN |
denotes |
hormone |
T381 |
1113-1117 |
NN |
denotes |
RXRβ |
T382 |
1117-1118 |
. |
denotes |
. |
T383 |
1118-1130 |
sentence |
denotes |
Conclusion |
T384 |
1120-1130 |
NN |
denotes |
Conclusion |
T385 |
1130-1241 |
sentence |
denotes |
The data so far suggest that the ancestral TACC protein played a role in centrosomal/mitotic spindle dynamics. |
T386 |
1131-1134 |
DT |
denotes |
The |
T387 |
1135-1139 |
NNS |
denotes |
data |
T388 |
1147-1154 |
VBP |
denotes |
suggest |
T389 |
1140-1142 |
RB |
denotes |
so |
T390 |
1143-1146 |
RB |
denotes |
far |
T391 |
1155-1159 |
IN |
denotes |
that |
T392 |
1187-1193 |
VBD |
denotes |
played |
T393 |
1160-1163 |
DT |
denotes |
the |
T394 |
1179-1186 |
NN |
denotes |
protein |
T395 |
1164-1173 |
JJ |
denotes |
ancestral |
T396 |
1174-1178 |
NN |
denotes |
TACC |
T397 |
1194-1195 |
DT |
denotes |
a |
T398 |
1196-1200 |
NN |
denotes |
role |
T399 |
1201-1203 |
IN |
denotes |
in |
T400 |
1204-1215 |
JJ |
denotes |
centrosomal |
T401 |
1216-1223 |
JJ |
denotes |
mitotic |
T402 |
1215-1216 |
HYPH |
denotes |
/ |
T403 |
1232-1240 |
NNS |
denotes |
dynamics |
T404 |
1224-1231 |
NN |
denotes |
spindle |
T405 |
1240-1241 |
. |
denotes |
. |
T406 |
1241-1403 |
sentence |
denotes |
TACC proteins were then recruited to complexes involved in protein translation, RNA processing and transcription by interactions with specific bridging proteins. |
T407 |
1242-1246 |
NN |
denotes |
TACC |
T408 |
1247-1255 |
NN |
denotes |
proteins |
T409 |
1266-1275 |
VBN |
denotes |
recruited |
T410 |
1256-1260 |
VBD |
denotes |
were |
T411 |
1261-1265 |
RB |
denotes |
then |
T412 |
1276-1278 |
IN |
denotes |
to |
T413 |
1279-1288 |
NNS |
denotes |
complexes |
T414 |
1289-1297 |
VBN |
denotes |
involved |
T415 |
1298-1300 |
IN |
denotes |
in |
T416 |
1301-1308 |
NN |
denotes |
protein |
T417 |
1309-1320 |
NN |
denotes |
translation |
T418 |
1320-1322 |
, |
denotes |
, |
T419 |
1322-1325 |
NN |
denotes |
RNA |
T420 |
1326-1336 |
NN |
denotes |
processing |
T421 |
1337-1340 |
CC |
denotes |
and |
T422 |
1341-1354 |
NN |
denotes |
transcription |
T423 |
1355-1357 |
IN |
denotes |
by |
T424 |
1358-1370 |
NNS |
denotes |
interactions |
T425 |
1371-1375 |
IN |
denotes |
with |
T426 |
1376-1384 |
JJ |
denotes |
specific |
T427 |
1394-1402 |
NN |
denotes |
proteins |
T428 |
1385-1393 |
NN |
denotes |
bridging |
T429 |
1402-1403 |
. |
denotes |
. |
T430 |
1403-1623 |
sentence |
denotes |
However, during evolution, the TACC proteins have now acquired the ability to directly interact with components of these complexes (such as the LSm proteins, nuclear hormone receptors, GAS41, and transcription factors). |
T431 |
1404-1411 |
RB |
denotes |
However |
T432 |
1458-1466 |
VBN |
denotes |
acquired |
T433 |
1411-1413 |
, |
denotes |
, |
T434 |
1413-1419 |
IN |
denotes |
during |
T435 |
1420-1429 |
NN |
denotes |
evolution |
T436 |
1429-1431 |
, |
denotes |
, |
T437 |
1431-1434 |
DT |
denotes |
the |
T438 |
1440-1448 |
NN |
denotes |
proteins |
T439 |
1435-1439 |
NN |
denotes |
TACC |
T440 |
1449-1453 |
VBP |
denotes |
have |
T441 |
1454-1457 |
RB |
denotes |
now |
T442 |
1467-1470 |
DT |
denotes |
the |
T443 |
1471-1478 |
NN |
denotes |
ability |
T444 |
1479-1481 |
TO |
denotes |
to |
T445 |
1491-1499 |
VB |
denotes |
interact |
T446 |
1482-1490 |
RB |
denotes |
directly |
T447 |
1500-1504 |
IN |
denotes |
with |
T448 |
1505-1515 |
NNS |
denotes |
components |
T449 |
1516-1518 |
IN |
denotes |
of |
T450 |
1519-1524 |
DT |
denotes |
these |
T451 |
1525-1534 |
NNS |
denotes |
complexes |
T452 |
1535-1536 |
-LRB- |
denotes |
( |
T453 |
1536-1540 |
JJ |
denotes |
such |
T454 |
1541-1543 |
IN |
denotes |
as |
T455 |
1544-1547 |
DT |
denotes |
the |
T456 |
1552-1560 |
NN |
denotes |
proteins |
T457 |
1548-1551 |
NN |
denotes |
LSm |
T458 |
1560-1562 |
, |
denotes |
, |
T459 |
1562-1569 |
JJ |
denotes |
nuclear |
T460 |
1578-1587 |
NNS |
denotes |
receptors |
T461 |
1570-1577 |
NN |
denotes |
hormone |
T462 |
1587-1589 |
, |
denotes |
, |
T463 |
1589-1594 |
NN |
denotes |
GAS41 |
T464 |
1594-1596 |
, |
denotes |
, |
T465 |
1596-1599 |
CC |
denotes |
and |
T466 |
1600-1613 |
NN |
denotes |
transcription |
T467 |
1614-1621 |
NNS |
denotes |
factors |
T468 |
1621-1622 |
-RRB- |
denotes |
) |
T469 |
1622-1623 |
. |
denotes |
. |
T470 |
1623-1910 |
sentence |
denotes |
This suggests that the function of the TACC proteins may have evolved from performing assembly or coordination functions in the centrosome to include a more intimate role in the functional evolution of chromatin remodeling, transcriptional and posttranscriptional complexes in the cell. |
T471 |
1624-1628 |
DT |
denotes |
This |
T472 |
1629-1637 |
VBZ |
denotes |
suggests |
T473 |
1638-1642 |
IN |
denotes |
that |
T474 |
1686-1693 |
VBN |
denotes |
evolved |
T475 |
1643-1646 |
DT |
denotes |
the |
T476 |
1647-1655 |
NN |
denotes |
function |
T477 |
1656-1658 |
IN |
denotes |
of |
T478 |
1659-1662 |
DT |
denotes |
the |
T479 |
1668-1676 |
NN |
denotes |
proteins |
T480 |
1663-1667 |
NN |
denotes |
TACC |
T481 |
1677-1680 |
MD |
denotes |
may |
T482 |
1681-1685 |
VB |
denotes |
have |
T483 |
1694-1698 |
IN |
denotes |
from |
T484 |
1699-1709 |
VBG |
denotes |
performing |
T485 |
1710-1718 |
NN |
denotes |
assembly |
T486 |
1735-1744 |
NNS |
denotes |
functions |
T487 |
1719-1721 |
CC |
denotes |
or |
T488 |
1722-1734 |
NN |
denotes |
coordination |
T489 |
1745-1747 |
IN |
denotes |
in |
T490 |
1748-1751 |
DT |
denotes |
the |
T491 |
1752-1762 |
NN |
denotes |
centrosome |
T492 |
1763-1765 |
TO |
denotes |
to |
T493 |
1766-1773 |
VB |
denotes |
include |
T494 |
1774-1775 |
DT |
denotes |
a |
T495 |
1790-1794 |
NN |
denotes |
role |
T496 |
1776-1780 |
RBR |
denotes |
more |
T497 |
1781-1789 |
JJ |
denotes |
intimate |
T498 |
1795-1797 |
IN |
denotes |
in |
T499 |
1798-1801 |
DT |
denotes |
the |
T500 |
1813-1822 |
NN |
denotes |
evolution |
T501 |
1802-1812 |
JJ |
denotes |
functional |
T502 |
1823-1825 |
IN |
denotes |
of |
T503 |
1826-1835 |
NN |
denotes |
chromatin |
T504 |
1836-1846 |
NN |
denotes |
remodeling |
T505 |
1846-1848 |
, |
denotes |
, |
T506 |
1848-1863 |
JJ |
denotes |
transcriptional |
T507 |
1888-1897 |
NNS |
denotes |
complexes |
T508 |
1864-1867 |
CC |
denotes |
and |
T509 |
1868-1887 |
JJ |
denotes |
posttranscriptional |
T510 |
1898-1900 |
IN |
denotes |
in |
T511 |
1901-1904 |
DT |
denotes |
the |
T512 |
1905-1909 |
NN |
denotes |
cell |
T513 |
1909-1910 |
. |
denotes |
. |
T193 |
0-10 |
sentence |
denotes |
Background |
R21 |
T200 |
T198 |
pobj |
families,of |
R22 |
T201 |
T200 |
compound |
gene,families |
R28 |
T207 |
T205 |
pcomp |
relate,into |
R29 |
T208 |
T209 |
det |
the,evolution |
R30 |
T209 |
T207 |
nsubj |
evolution,relate |
R31 |
T210 |
T209 |
prep |
of,evolution |
R32 |
T211 |
T212 |
compound |
gene,structure |
R33 |
T212 |
T210 |
pobj |
structure,of |
R34 |
T213 |
T207 |
aux |
can,relate |
R42 |
T223 |
T221 |
pobj |
family,of |
R43 |
T224 |
T225 |
advmod |
evolutionarily,conserved |
R44 |
T225 |
T223 |
amod |
conserved,family |
R45 |
T226 |
T227 |
amod |
transforming,coil |
R46 |
T227 |
T223 |
nmod |
coil,family |
R47 |
T228 |
T227 |
amod |
acidic,coil |
R48 |
T229 |
T227 |
amod |
coiled,coil |
R49 |
T230 |
T227 |
punct |
(,coil |
R50 |
T231 |
T227 |
appos |
TACC,coil |
R51 |
T232 |
T223 |
punct |
),family |
R52 |
T233 |
T223 |
compound |
gene,family |
R74 |
T257 |
T244 |
xcomp |
determined,have |
R75 |
T258 |
T257 |
aux |
to,determined |
R76 |
T259 |
T257 |
auxpass |
be,determined |
R81 |
T268 |
T265 |
dobj |
analysis,performed |
R82 |
T269 |
T268 |
amod |
extensive,analysis |
R83 |
T270 |
T268 |
compound |
database,analysis |
R87 |
T274 |
T272 |
dobj |
sequences,determine |
R88 |
T275 |
T274 |
amod |
genomic,sequences |
R89 |
T276 |
T275 |
cc |
and,genomic |
R90 |
T277 |
T275 |
conj |
cDNA,genomic |
R103 |
T292 |
T289 |
dobj |
relationship,determined |
R104 |
T293 |
T292 |
amod |
phylogenetic,relationship |
R107 |
T296 |
T294 |
pobj |
proteins,of |
R108 |
T297 |
T296 |
compound |
TACC,proteins |
R111 |
T300 |
T298 |
pobj |
proteins,to |
R112 |
T301 |
T302 |
amod |
coiled,coil |
R113 |
T302 |
T300 |
compound |
coil,proteins |
R122 |
T311 |
T309 |
pobj |
TACC4,of |
R123 |
T312 |
T311 |
compound |
rabbit,TACC4 |
R135 |
T324 |
T322 |
pobj |
family,as |
R136 |
T325 |
T324 |
amod |
distinct,family |
R152 |
T343 |
T341 |
pobj |
databases,to |
R153 |
T344 |
T343 |
compound |
interaction,databases |
R164 |
T355 |
T352 |
dobj |
interactions,identify |
R165 |
T356 |
T355 |
compound |
TACC,interactions |
R185 |
T378 |
T376 |
pobj |
receptor,to |
R186 |
T379 |
T378 |
amod |
nuclear,receptor |
R187 |
T380 |
T378 |
compound |
hormone,receptor |
R195 |
T392 |
T388 |
ccomp |
played,suggest |
R196 |
T393 |
T394 |
det |
the,protein |
R197 |
T394 |
T392 |
nsubj |
protein,played |
R198 |
T395 |
T394 |
amod |
ancestral,protein |
R199 |
T396 |
T394 |
compound |
TACC,protein |
R204 |
T401 |
T403 |
amod |
mitotic,dynamics |
R205 |
T402 |
T401 |
punct |
/,mitotic |
R206 |
T403 |
T399 |
pobj |
dynamics,in |
R207 |
T404 |
T403 |
compound |
spindle,dynamics |
R228 |
T427 |
T425 |
pobj |
proteins,with |
R229 |
T428 |
T427 |
compound |
bridging,proteins |
R237 |
T438 |
T432 |
nsubj |
proteins,acquired |
R238 |
T439 |
T438 |
compound |
TACC,proteins |
R244 |
T445 |
T443 |
acl |
interact,ability |
R245 |
T446 |
T445 |
advmod |
directly,interact |
R255 |
T456 |
T454 |
pobj |
proteins,as |
R256 |
T457 |
T456 |
compound |
LSm,proteins |
R259 |
T460 |
T456 |
conj |
receptors,proteins |
R260 |
T461 |
T460 |
compound |
hormone,receptors |
R271 |
T474 |
T472 |
ccomp |
evolved,suggests |
R272 |
T475 |
T476 |
det |
the,function |
R273 |
T476 |
T474 |
nsubj |
function,evolved |
R274 |
T477 |
T476 |
prep |
of,function |
R275 |
T478 |
T479 |
det |
the,proteins |
R277 |
T480 |
T479 |
compound |
TACC,proteins |
R278 |
T481 |
T474 |
aux |
may,evolved |
R279 |
T482 |
T474 |
aux |
have,evolved |
R283 |
T486 |
T484 |
dobj |
functions,performing |
R284 |
T487 |
T485 |
cc |
or,assembly |
R285 |
T488 |
T485 |
conj |
coordination,assembly |
R292 |
T495 |
T493 |
dobj |
role,include |
R293 |
T496 |
T497 |
advmod |
more,intimate |
R294 |
T497 |
T495 |
amod |
intimate,role |
R297 |
T500 |
T498 |
pobj |
evolution,in |
R298 |
T501 |
T500 |
amod |
functional,evolution |
R304 |
T507 |
T504 |
appos |
complexes,remodeling |
R305 |
T508 |
T506 |
cc |
and,transcriptional |
R306 |
T509 |
T506 |
conj |
posttranscriptional,transcriptional |
R66 |
T249 |
T247 |
pobj |
interactions,between |
R67 |
T250 |
T249 |
cc |
and,interactions |
R68 |
T251 |
T252 |
det |
the,evolution |
R69 |
T252 |
T249 |
conj |
evolution,interactions |
R70 |
T253 |
T252 |
prep |
of,evolution |
R71 |
T254 |
T255 |
det |
these,proteins |
R72 |
T255 |
T253 |
pobj |
proteins,of |
R85 |
T272 |
T265 |
advcl |
determine,performed |
R86 |
T273 |
T274 |
det |
the,sequences |
R91 |
T278 |
T274 |
prep |
of,sequences |
R92 |
T279 |
T280 |
det |
the,TACCs |
R93 |
T280 |
T278 |
pobj |
TACCs,of |
R94 |
T281 |
T280 |
prep |
from,TACCs |
R95 |
T282 |
T283 |
advmod |
phylogenetically,diverse |
R96 |
T283 |
T284 |
amod |
diverse,organisms |
R97 |
T284 |
T281 |
pobj |
organisms,from |
R98 |
T285 |
T265 |
punct |
.,performed |
R99 |
T287 |
T288 |
det |
This,analysis |
R100 |
T288 |
T289 |
nsubj |
analysis,determined |
R101 |
T290 |
T289 |
aux |
has,determined |
R102 |
T291 |
T292 |
det |
the,relationship |
R105 |
T294 |
T292 |
prep |
of,relationship |
R106 |
T295 |
T296 |
det |
the,proteins |
R109 |
T298 |
T292 |
prep |
to,relationship |
R110 |
T299 |
T300 |
amod |
other,proteins |
R114 |
T303 |
T292 |
punct |
", ",relationship |
R115 |
T304 |
T305 |
det |
the,resolution |
R116 |
T305 |
T292 |
conj |
resolution,relationship |
R117 |
T306 |
T305 |
prep |
of,resolution |
R118 |
T307 |
T308 |
det |
the,placement |
R119 |
T308 |
T306 |
pobj |
placement,of |
R120 |
T309 |
T308 |
prep |
of,placement |
R121 |
T310 |
T311 |
det |
the,TACC4 |
R124 |
T313 |
T308 |
prep |
as,placement |
R125 |
T314 |
T315 |
det |
the,orthologue |
R126 |
T315 |
T313 |
pobj |
orthologue,as |
R127 |
T316 |
T315 |
prep |
of,orthologue |
R128 |
T317 |
T318 |
amod |
human,TACC3 |
R129 |
T318 |
T316 |
pobj |
TACC3,of |
R130 |
T319 |
T305 |
punct |
", ",resolution |
R131 |
T320 |
T305 |
cc |
and,resolution |
R132 |
T321 |
T305 |
conj |
RHAMM,resolution |
R133 |
T322 |
T321 |
prep |
as,RHAMM |
R134 |
T323 |
T324 |
det |
a,family |
R137 |
T326 |
T324 |
prep |
of,family |
R138 |
T327 |
T328 |
amod |
coiled,coil |
R139 |
T328 |
T329 |
compound |
coil,proteins |
R140 |
T329 |
T326 |
pobj |
proteins,of |
R141 |
T330 |
T289 |
punct |
.,determined |
R142 |
T332 |
T333 |
nsubj |
We,extended |
R143 |
T334 |
T333 |
aux |
have,extended |
R144 |
T335 |
T333 |
advmod |
also,extended |
R145 |
T336 |
T337 |
det |
the,analysis |
R146 |
T337 |
T333 |
dobj |
analysis,extended |
R147 |
T338 |
T337 |
prep |
of,analysis |
R148 |
T339 |
T340 |
det |
the,TACCs |
R149 |
T340 |
T338 |
pobj |
TACCs,of |
R150 |
T341 |
T333 |
prep |
to,extended |
R151 |
T342 |
T343 |
det |
the,databases |
R154 |
T345 |
T343 |
prep |
of,databases |
R155 |
T346 |
T347 |
compound |
C.,elegans |
R156 |
T347 |
T345 |
pobj |
elegans,of |
R157 |
T348 |
T347 |
cc |
and,elegans |
R158 |
T349 |
T350 |
compound |
D.,melanogaster |
R159 |
T350 |
T347 |
conj |
melanogaster,elegans |
R160 |
T351 |
T352 |
aux |
to,identify |
R161 |
T352 |
T333 |
advcl |
identify,extended |
R162 |
T353 |
T354 |
advmod |
potentially,novel |
R163 |
T354 |
T355 |
amod |
novel,interactions |
R166 |
T357 |
T333 |
punct |
.,extended |
R167 |
T359 |
T360 |
det |
The,validity |
R276 |
T479 |
T477 |
pobj |
proteins,of |
R280 |
T483 |
T474 |
prep |
from,evolved |
R281 |
T484 |
T483 |
pcomp |
performing,from |
R282 |
T485 |
T486 |
nmod |
assembly,functions |
R286 |
T489 |
T484 |
prep |
in,performing |
R287 |
T490 |
T491 |
det |
the,centrosome |
R288 |
T491 |
T489 |
pobj |
centrosome,in |
R289 |
T492 |
T493 |
aux |
to,include |
R290 |
T493 |
T474 |
advcl |
include,evolved |
R291 |
T494 |
T495 |
det |
a,role |
R295 |
T498 |
T495 |
prep |
in,role |
R296 |
T499 |
T500 |
det |
the,evolution |
R299 |
T502 |
T500 |
prep |
of,evolution |
R300 |
T503 |
T504 |
compound |
chromatin,remodeling |
R301 |
T504 |
T502 |
pobj |
remodeling,of |
R302 |
T505 |
T504 |
punct |
", ",remodeling |
R303 |
T506 |
T507 |
amod |
transcriptional,complexes |
R307 |
T510 |
T500 |
prep |
in,evolution |
R308 |
T511 |
T512 |
det |
the,cell |
R309 |
T512 |
T510 |
pobj |
cell,in |
R310 |
T513 |
T472 |
punct |
.,suggests |
R18 |
T196 |
T197 |
nsubj |
Examination,provide |
R19 |
T198 |
T196 |
prep |
of,Examination |
R20 |
T199 |
T200 |
amod |
ancient,families |
R23 |
T202 |
T197 |
aux |
can,provide |
R24 |
T203 |
T204 |
det |
an,insight |
R25 |
T204 |
T197 |
dobj |
insight,provide |
R26 |
T205 |
T204 |
prep |
into,insight |
R27 |
T206 |
T207 |
advmod |
how,relate |
R35 |
T214 |
T207 |
prep |
to,relate |
R36 |
T215 |
T214 |
pobj |
function,to |
R37 |
T216 |
T197 |
punct |
.,provide |
R38 |
T218 |
T219 |
amod |
Functional,homologs |
R39 |
T219 |
T220 |
nsubj |
homologs,are |
R40 |
T221 |
T219 |
prep |
of,homologs |
R41 |
T222 |
T223 |
det |
the,family |
R53 |
T234 |
T220 |
acomp |
present,are |
R54 |
T235 |
T220 |
prep |
in,are |
R55 |
T236 |
T235 |
pobj |
organisms,in |
R56 |
T237 |
T236 |
prep |
from,organisms |
R57 |
T238 |
T237 |
pobj |
yeast,from |
R58 |
T239 |
T237 |
prep |
to,from |
R59 |
T240 |
T239 |
pobj |
man,to |
R60 |
T241 |
T220 |
punct |
.,are |
R61 |
T243 |
T244 |
advmod |
However,have |
R62 |
T245 |
T244 |
punct |
", ",have |
R63 |
T246 |
T244 |
nsubj |
correlations,have |
R64 |
T247 |
T246 |
prep |
between,correlations |
R65 |
T248 |
T249 |
amod |
functional,interactions |
R73 |
T256 |
T257 |
advmod |
yet,determined |
R77 |
T260 |
T244 |
punct |
.,have |
R78 |
T264 |
T265 |
nsubj |
We,performed |
R79 |
T266 |
T265 |
aux |
have,performed |
R80 |
T267 |
T268 |
det |
an,analysis |
R84 |
T271 |
T272 |
aux |
to,determine |
R168 |
T360 |
T361 |
nsubjpass |
validity,confirmed |
R169 |
T362 |
T360 |
prep |
of,validity |
R170 |
T363 |
T364 |
det |
this,modeling |
R171 |
T364 |
T362 |
pobj |
modeling,of |
R172 |
T365 |
T361 |
auxpass |
was,confirmed |
R173 |
T366 |
T361 |
advmod |
independently,confirmed |
R174 |
T367 |
T361 |
prep |
by,confirmed |
R175 |
T368 |
T369 |
det |
the,demonstration |
R176 |
T369 |
T367 |
pobj |
demonstration,by |
R177 |
T370 |
T369 |
prep |
of,demonstration |
R178 |
T371 |
T372 |
amod |
direct,binding |
R179 |
T372 |
T370 |
pobj |
binding,of |
R180 |
T373 |
T372 |
prep |
of,binding |
R181 |
T374 |
T375 |
amod |
human,TACC2 |
R182 |
T375 |
T373 |
pobj |
TACC2,of |
R183 |
T376 |
T372 |
prep |
to,binding |
R184 |
T377 |
T378 |
det |
the,receptor |
R188 |
T381 |
T378 |
appos |
RXRβ,receptor |
R189 |
T382 |
T361 |
punct |
.,confirmed |
R190 |
T386 |
T387 |
det |
The,data |
R191 |
T387 |
T388 |
nsubj |
data,suggest |
R192 |
T389 |
T390 |
advmod |
so,far |
R193 |
T390 |
T387 |
advmod |
far,data |
R194 |
T391 |
T392 |
mark |
that,played |
R200 |
T397 |
T398 |
det |
a,role |
R201 |
T398 |
T392 |
dobj |
role,played |
R202 |
T399 |
T392 |
prep |
in,played |
R203 |
T400 |
T401 |
amod |
centrosomal,mitotic |
R208 |
T405 |
T388 |
punct |
.,suggest |
R209 |
T407 |
T408 |
compound |
TACC,proteins |
R210 |
T408 |
T409 |
nsubjpass |
proteins,recruited |
R211 |
T410 |
T409 |
auxpass |
were,recruited |
R212 |
T411 |
T409 |
advmod |
then,recruited |
R213 |
T412 |
T409 |
prep |
to,recruited |
R214 |
T413 |
T412 |
pobj |
complexes,to |
R215 |
T414 |
T413 |
acl |
involved,complexes |
R216 |
T415 |
T414 |
prep |
in,involved |
R217 |
T416 |
T417 |
compound |
protein,translation |
R218 |
T417 |
T415 |
pobj |
translation,in |
R219 |
T418 |
T417 |
punct |
", ",translation |
R220 |
T419 |
T420 |
compound |
RNA,processing |
R221 |
T420 |
T417 |
conj |
processing,translation |
R222 |
T421 |
T420 |
cc |
and,processing |
R223 |
T422 |
T420 |
conj |
transcription,processing |
R224 |
T423 |
T414 |
prep |
by,involved |
R225 |
T424 |
T423 |
pobj |
interactions,by |
R226 |
T425 |
T424 |
prep |
with,interactions |
R227 |
T426 |
T427 |
amod |
specific,proteins |
R230 |
T429 |
T409 |
punct |
.,recruited |
R231 |
T431 |
T432 |
advmod |
However,acquired |
R232 |
T433 |
T432 |
punct |
", ",acquired |
R233 |
T434 |
T432 |
prep |
during,acquired |
R234 |
T435 |
T434 |
pobj |
evolution,during |
R235 |
T436 |
T432 |
punct |
", ",acquired |
R236 |
T437 |
T438 |
det |
the,proteins |
R239 |
T440 |
T432 |
aux |
have,acquired |
R240 |
T441 |
T432 |
advmod |
now,acquired |
R241 |
T442 |
T443 |
det |
the,ability |
R242 |
T443 |
T432 |
dobj |
ability,acquired |
R243 |
T444 |
T445 |
aux |
to,interact |
R246 |
T447 |
T445 |
prep |
with,interact |
R247 |
T448 |
T447 |
pobj |
components,with |
R248 |
T449 |
T448 |
prep |
of,components |
R249 |
T450 |
T451 |
det |
these,complexes |
R250 |
T451 |
T449 |
pobj |
complexes,of |
R251 |
T452 |
T448 |
punct |
(,components |
R252 |
T453 |
T454 |
amod |
such,as |
R253 |
T454 |
T448 |
prep |
as,components |
R254 |
T455 |
T456 |
det |
the,proteins |
R257 |
T458 |
T456 |
punct |
", ",proteins |
R258 |
T459 |
T460 |
amod |
nuclear,receptors |
R261 |
T462 |
T460 |
punct |
", ",receptors |
R262 |
T463 |
T460 |
conj |
GAS41,receptors |
R263 |
T464 |
T463 |
punct |
", ",GAS41 |
R264 |
T465 |
T463 |
cc |
and,GAS41 |
R265 |
T466 |
T467 |
compound |
transcription,factors |
R266 |
T467 |
T463 |
conj |
factors,GAS41 |
R267 |
T468 |
T448 |
punct |
),components |
R268 |
T469 |
T432 |
punct |
.,acquired |
R269 |
T471 |
T472 |
nsubj |
This,suggests |
R270 |
T473 |
T474 |
mark |
that,evolved |