PMC:441373 / 13164-14594 JSONTXT

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We identified a single RHAMM gene in all deuterostomes for which cDNA and/or genomic sequence was available, including C. intestinalis. No RHAMM gene was identified in insects or nematodes. This indicates that the RHAMM/TACC genes diverged after the protostome/deuterostome split 833–933 MYA, but prior to the echinodermata/urochordate divergence (\u003e750 MYA). Significantly, sequence and phylogenetic analysis of coiled coil proteins (Fig. 1) clearly shows that RHAMM does not contain a TACC domain and instead forms a distinct family of proteins in the coiled coil superfamily, and is not a direct descendant of the ancestral TACC 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