PMC:441373 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T173	0-9	NN	denotes	Structure
T174	10-18	NN	denotes	function
T175	0-132	sentence	denotes	Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms
T176	9-10	HYPH	denotes	-
T177	19-28	NN	denotes	evolution
T178	29-31	IN	denotes	of
T179	32-35	DT	denotes	the
T180	68-73	NNS	denotes	genes
T181	36-48	VBG	denotes	Transforming
T182	49-55	JJ	denotes	acidic
T183	56-62	VBN	denotes	coiled
T184	63-67	NN	denotes	coil
T185	74-82	VBN	denotes	revealed
T186	83-85	IN	denotes	by
T187	86-94	NN	denotes	analysis
T188	95-97	IN	denotes	of
T189	98-114	RB	denotes	phylogenetically
T190	115-122	JJ	denotes	diverse
T191	123-132	NNS	denotes	organisms
T192	132-133	sentence	denotes
T194	143-153	NN	denotes	Background
T195	153-278	sentence	denotes	Examination of ancient gene families can provide an insight into how the evolution of gene structure can relate to function.
T196	154-165	NN	denotes	Examination
T197	195-202	VB	denotes	provide
T198	166-168	IN	denotes	of
T199	169-176	JJ	denotes	ancient
T200	182-190	NNS	denotes	families
T201	177-181	NN	denotes	gene
T202	191-194	MD	denotes	can
T203	203-205	DT	denotes	an
T204	206-213	NN	denotes	insight
T205	214-218	IN	denotes	into
T206	219-222	WRB	denotes	how
T207	259-265	VB	denotes	relate
T208	223-226	DT	denotes	the
T209	227-236	NN	denotes	evolution
T210	237-239	IN	denotes	of
T211	240-244	NN	denotes	gene
T212	245-254	NN	denotes	structure
T213	255-258	MD	denotes	can
T214	266-268	IN	denotes	to
T215	269-277	NN	denotes	function
T216	277-278	.	denotes	.
T217	278-425	sentence	denotes	Functional homologs of the evolutionarily conserved transforming acidic coiled coil (TACC) gene family are present in organisms from yeast to man.
T218	279-289	JJ	denotes	Functional
T219	290-298	NNS	denotes	homologs
T220	382-385	VBP	denotes	are
T221	299-301	IN	denotes	of
T222	302-305	DT	denotes	the
T223	375-381	NN	denotes	family
T224	306-320	RB	denotes	evolutionarily
T225	321-330	VBN	denotes	conserved
T226	331-343	VBG	denotes	transforming
T227	358-362	NN	denotes	coil
T228	344-350	JJ	denotes	acidic
T229	351-357	VBN	denotes	coiled
T230	363-364	-LRB-	denotes	(
T231	364-368	NN	denotes	TACC
T232	368-369	-RRB-	denotes	)
T233	370-374	NN	denotes	gene
T234	386-393	JJ	denotes	present
T235	394-396	IN	denotes	in
T236	397-406	NNS	denotes	organisms
T237	407-411	IN	denotes	from
T238	412-417	NN	denotes	yeast
T239	418-420	IN	denotes	to
T240	421-424	NN	denotes	man
T241	424-425	.	denotes	.
T242	425-542	sentence	denotes	However, correlations between functional interactions and the evolution of these proteins have yet to be determined.
T243	426-433	RB	denotes	However
T244	516-520	VBP	denotes	have
T245	433-435	,	denotes	,
T246	435-447	NNS	denotes	correlations
T247	448-455	IN	denotes	between
T248	456-466	JJ	denotes	functional
T249	467-479	NNS	denotes	interactions
T250	480-483	CC	denotes	and
T251	484-487	DT	denotes	the
T252	488-497	NN	denotes	evolution
T253	498-500	IN	denotes	of
T254	501-506	DT	denotes	these
T255	507-515	NN	denotes	proteins
T256	521-524	RB	denotes	yet
T257	531-541	VBN	denotes	determined
T258	525-527	TO	denotes	to
T259	528-530	VB	denotes	be
T260	541-542	.	denotes	.
T261	542-551	sentence	denotes	Results
T262	544-551	NNS	denotes	Results
T263	551-698	sentence	denotes	We have performed an extensive database analysis to determine the genomic and cDNA sequences of the TACCs from phylogenetically diverse organisms.
T264	552-554	PRP	denotes	We
T265	560-569	VBN	denotes	performed
T266	555-559	VBP	denotes	have
T267	570-572	DT	denotes	an
T268	592-600	NN	denotes	analysis
T269	573-582	JJ	denotes	extensive
T270	583-591	NN	denotes	database
T271	601-603	TO	denotes	to
T272	604-613	VB	denotes	determine
T273	614-617	DT	denotes	the
T274	635-644	NNS	denotes	sequences
T275	618-625	JJ	denotes	genomic
T276	626-629	CC	denotes	and
T277	630-634	NN	denotes	cDNA
T278	645-647	IN	denotes	of
T279	648-651	DT	denotes	the
T280	652-657	NNS	denotes	TACCs
T281	658-662	IN	denotes	from
T282	663-679	RB	denotes	phylogenetically
T283	680-687	JJ	denotes	diverse
T284	688-697	NNS	denotes	organisms
T285	697-698	.	denotes	.
T286	698-951	sentence	denotes	This analysis has determined the phylogenetic relationship of the TACC proteins to other coiled coil proteins, the resolution of the placement of the rabbit TACC4 as the orthologue of human TACC3, and RHAMM as a distinct family of coiled coil proteins.
T287	699-703	DT	denotes	This
T288	704-712	NN	denotes	analysis
T289	717-727	VBN	denotes	determined
T290	713-716	VBZ	denotes	has
T291	728-731	DT	denotes	the
T292	745-757	NN	denotes	relationship
T293	732-744	JJ	denotes	phylogenetic
T294	758-760	IN	denotes	of
T295	761-764	DT	denotes	the
T296	770-778	NN	denotes	proteins
T297	765-769	NN	denotes	TACC
T298	779-781	IN	denotes	to
T299	782-787	JJ	denotes	other
T300	800-808	NN	denotes	proteins
T301	788-794	VBN	denotes	coiled
T302	795-799	NN	denotes	coil
T303	808-810	,	denotes	,
T304	810-813	DT	denotes	the
T305	814-824	NN	denotes	resolution
T306	825-827	IN	denotes	of
T307	828-831	DT	denotes	the
T308	832-841	NN	denotes	placement
T309	842-844	IN	denotes	of
T310	845-848	DT	denotes	the
T311	856-861	NN	denotes	TACC4
T312	849-855	NN	denotes	rabbit
T313	862-864	IN	denotes	as
T314	865-868	DT	denotes	the
T315	869-879	NN	denotes	orthologue
T316	880-882	IN	denotes	of
T317	883-888	JJ	denotes	human
T318	889-894	NN	denotes	TACC3
T319	894-896	,	denotes	,
T320	896-899	CC	denotes	and
T321	900-905	NN	denotes	RHAMM
T322	906-908	IN	denotes	as
T323	909-910	DT	denotes	a
T324	920-926	NN	denotes	family
T325	911-919	JJ	denotes	distinct
T326	927-929	IN	denotes	of
T327	930-936	VBN	denotes	coiled
T328	937-941	NN	denotes	coil
T329	942-950	NN	denotes	proteins
T330	950-951	.	denotes	.
T331	951-1111	sentence	denotes	We have also extended the analysis of the TACCs to the interaction databases of C. elegans and D. melanogaster to identify potentially novel TACC interactions.
T332	952-954	PRP	denotes	We
T333	965-973	VBN	denotes	extended
T334	955-959	VBP	denotes	have
T335	960-964	RB	denotes	also
T336	974-977	DT	denotes	the
T337	978-986	NN	denotes	analysis
T338	987-989	IN	denotes	of
T339	990-993	DT	denotes	the
T340	994-999	NNS	denotes	TACCs
T341	1000-1002	IN	denotes	to
T342	1003-1006	DT	denotes	the
T343	1019-1028	NNS	denotes	databases
T344	1007-1018	NN	denotes	interaction
T345	1029-1031	IN	denotes	of
T346	1032-1034	NNP	denotes	C.
T347	1035-1042	NNP	denotes	elegans
T348	1043-1046	CC	denotes	and
T349	1047-1049	NNP	denotes	D.
T350	1050-1062	NNP	denotes	melanogaster
T351	1063-1065	TO	denotes	to
T352	1066-1074	VB	denotes	identify
T353	1075-1086	RB	denotes	potentially
T354	1087-1092	JJ	denotes	novel
T355	1098-1110	NNS	denotes	interactions
T356	1093-1097	NN	denotes	TACC
T357	1110-1111	.	denotes	.
T358	1111-1261	sentence	denotes	The validity of this modeling was confirmed independently by the demonstration of direct binding of human TACC2 to the nuclear hormone receptor RXRβ.
T359	1112-1115	DT	denotes	The
T360	1116-1124	NN	denotes	validity
T361	1146-1155	VBN	denotes	confirmed
T362	1125-1127	IN	denotes	of
T363	1128-1132	DT	denotes	this
T364	1133-1141	NN	denotes	modeling
T365	1142-1145	VBD	denotes	was
T366	1156-1169	RB	denotes	independently
T367	1170-1172	IN	denotes	by
T368	1173-1176	DT	denotes	the
T369	1177-1190	NN	denotes	demonstration
T370	1191-1193	IN	denotes	of
T371	1194-1200	JJ	denotes	direct
T372	1201-1208	NN	denotes	binding
T373	1209-1211	IN	denotes	of
T374	1212-1217	JJ	denotes	human
T375	1218-1223	NN	denotes	TACC2
T376	1224-1226	IN	denotes	to
T377	1227-1230	DT	denotes	the
T378	1247-1255	NN	denotes	receptor
T379	1231-1238	JJ	denotes	nuclear
T380	1239-1246	NN	denotes	hormone
T381	1256-1260	NN	denotes	RXRβ
T382	1260-1261	.	denotes	.
T383	1261-1273	sentence	denotes	Conclusion
T384	1263-1273	NN	denotes	Conclusion
T385	1273-1384	sentence	denotes	The data so far suggest that the ancestral TACC protein played a role in centrosomal/mitotic spindle dynamics.
T386	1274-1277	DT	denotes	The
T387	1278-1282	NNS	denotes	data
T388	1290-1297	VBP	denotes	suggest
T389	1283-1285	RB	denotes	so
T390	1286-1289	RB	denotes	far
T391	1298-1302	IN	denotes	that
T392	1330-1336	VBD	denotes	played
T393	1303-1306	DT	denotes	the
T394	1322-1329	NN	denotes	protein
T395	1307-1316	JJ	denotes	ancestral
T396	1317-1321	NN	denotes	TACC
T397	1337-1338	DT	denotes	a
T398	1339-1343	NN	denotes	role
T399	1344-1346	IN	denotes	in
T400	1347-1358	JJ	denotes	centrosomal
T401	1359-1366	JJ	denotes	mitotic
T402	1358-1359	HYPH	denotes	/
T403	1375-1383	NNS	denotes	dynamics
T404	1367-1374	NN	denotes	spindle
T405	1383-1384	.	denotes	.
T406	1384-1546	sentence	denotes	TACC proteins were then recruited to complexes involved in protein translation, RNA processing and transcription by interactions with specific bridging proteins.
T407	1385-1389	NN	denotes	TACC
T408	1390-1398	NN	denotes	proteins
T409	1409-1418	VBN	denotes	recruited
T410	1399-1403	VBD	denotes	were
T411	1404-1408	RB	denotes	then
T412	1419-1421	IN	denotes	to
T413	1422-1431	NNS	denotes	complexes
T414	1432-1440	VBN	denotes	involved
T415	1441-1443	IN	denotes	in
T416	1444-1451	NN	denotes	protein
T417	1452-1463	NN	denotes	translation
T418	1463-1465	,	denotes	,
T419	1465-1468	NN	denotes	RNA
T420	1469-1479	NN	denotes	processing
T421	1480-1483	CC	denotes	and
T422	1484-1497	NN	denotes	transcription
T423	1498-1500	IN	denotes	by
T424	1501-1513	NNS	denotes	interactions
T425	1514-1518	IN	denotes	with
T426	1519-1527	JJ	denotes	specific
T427	1537-1545	NN	denotes	proteins
T428	1528-1536	NN	denotes	bridging
T429	1545-1546	.	denotes	.
T430	1546-1766	sentence	denotes	However, during evolution, the TACC proteins have now acquired the ability to directly interact with components of these complexes (such as the LSm proteins, nuclear hormone receptors, GAS41, and transcription factors).
T431	1547-1554	RB	denotes	However
T432	1601-1609	VBN	denotes	acquired
T433	1554-1556	,	denotes	,
T434	1556-1562	IN	denotes	during
T435	1563-1572	NN	denotes	evolution
T436	1572-1574	,	denotes	,
T437	1574-1577	DT	denotes	the
T438	1583-1591	NN	denotes	proteins
T439	1578-1582	NN	denotes	TACC
T440	1592-1596	VBP	denotes	have
T441	1597-1600	RB	denotes	now
T442	1610-1613	DT	denotes	the
T443	1614-1621	NN	denotes	ability
T444	1622-1624	TO	denotes	to
T445	1634-1642	VB	denotes	interact
T446	1625-1633	RB	denotes	directly
T447	1643-1647	IN	denotes	with
T448	1648-1658	NNS	denotes	components
T449	1659-1661	IN	denotes	of
T450	1662-1667	DT	denotes	these
T451	1668-1677	NNS	denotes	complexes
T452	1678-1679	-LRB-	denotes	(
T453	1679-1683	JJ	denotes	such
T454	1684-1686	IN	denotes	as
T455	1687-1690	DT	denotes	the
T456	1695-1703	NN	denotes	proteins
T457	1691-1694	NN	denotes	LSm
T458	1703-1705	,	denotes	,
T459	1705-1712	JJ	denotes	nuclear
T460	1721-1730	NNS	denotes	receptors
T461	1713-1720	NN	denotes	hormone
T462	1730-1732	,	denotes	,
T463	1732-1737	NN	denotes	GAS41
T464	1737-1739	,	denotes	,
T465	1739-1742	CC	denotes	and
T466	1743-1756	NN	denotes	transcription
T467	1757-1764	NNS	denotes	factors
T468	1764-1765	-RRB-	denotes	)
T469	1765-1766	.	denotes	.
T470	1766-2053	sentence	denotes	This suggests that the function of the TACC proteins may have evolved from performing assembly or coordination functions in the centrosome to include a more intimate role in the functional evolution of chromatin remodeling, transcriptional and posttranscriptional complexes in the cell.
T471	1767-1771	DT	denotes	This
T472	1772-1780	VBZ	denotes	suggests
T473	1781-1785	IN	denotes	that
T474	1829-1836	VBN	denotes	evolved
T475	1786-1789	DT	denotes	the
T476	1790-1798	NN	denotes	function
T477	1799-1801	IN	denotes	of
T478	1802-1805	DT	denotes	the
T479	1811-1819	NN	denotes	proteins
T480	1806-1810	NN	denotes	TACC
T481	1820-1823	MD	denotes	may
T482	1824-1828	VB	denotes	have
T483	1837-1841	IN	denotes	from
T484	1842-1852	VBG	denotes	performing
T485	1853-1861	NN	denotes	assembly
T486	1878-1887	NNS	denotes	functions
T487	1862-1864	CC	denotes	or
T488	1865-1877	NN	denotes	coordination
T489	1888-1890	IN	denotes	in
T490	1891-1894	DT	denotes	the
T491	1895-1905	NN	denotes	centrosome
T492	1906-1908	TO	denotes	to
T493	1909-1916	VB	denotes	include
T494	1917-1918	DT	denotes	a
T495	1933-1937	NN	denotes	role
T496	1919-1923	RBR	denotes	more
T497	1924-1932	JJ	denotes	intimate
T498	1938-1940	IN	denotes	in
T499	1941-1944	DT	denotes	the
T500	1956-1965	NN	denotes	evolution
T501	1945-1955	JJ	denotes	functional
T502	1966-1968	IN	denotes	of
T503	1969-1978	NN	denotes	chromatin
T504	1979-1989	NN	denotes	remodeling
T505	1989-1991	,	denotes	,
T506	1991-2006	JJ	denotes	transcriptional
T507	2031-2040	NNS	denotes	complexes
T508	2007-2010	CC	denotes	and
T509	2011-2030	JJ	denotes	posttranscriptional
T510	2041-2043	IN	denotes	in
T511	2044-2047	DT	denotes	the
T512	2048-2052	NN	denotes	cell
T513	2052-2053	.	denotes	.
T703	2066-2069	DT	denotes	The
T704	2070-2079	NN	denotes	evolution
T705	2110-2120	VBN	denotes	associated
T706	2080-2082	IN	denotes	of
T707	2083-2090	JJ	denotes	complex
T708	2091-2100	NNS	denotes	organisms
T709	2101-2104	VBZ	denotes	has
T710	2105-2109	VBN	denotes	been
T711	2121-2125	IN	denotes	with
T712	2126-2129	DT	denotes	the
T713	2130-2140	NN	denotes	generation
T714	2141-2143	IN	denotes	of
T715	2144-2148	NN	denotes	gene
T716	2149-2157	NNS	denotes	families
T717	2158-2160	IN	denotes	by
T718	2161-2164	DT	denotes	the
T719	2175-2186	NN	denotes	duplication
T720	2165-2174	JJ	denotes	continual
T721	2187-2189	IN	denotes	of
T722	2190-2192	DT	denotes	an
T723	2218-2221	NN	denotes	set
T724	2193-2200	JJ	denotes	initial
T725	2201-2211	RB	denotes	relatively
T726	2212-2217	JJ	denotes	small
T727	2222-2224	IN	denotes	of
T728	2225-2234	JJ	denotes	ancestral
T729	2235-2240	NNS	denotes	genes
T730	2240-2241	.	denotes	.
T731	2241-2455	sentence	denotes	Through this process, followed by subsequent mutation, reduplication and exon shuffling between gene families, genes have evolved both discrete, and partially redundant functions with their related family members.
T732	2242-2249	IN	denotes	Through
T733	2364-2371	VBN	denotes	evolved
T734	2250-2254	DT	denotes	this
T735	2255-2262	NN	denotes	process
T736	2262-2264	,	denotes	,
T737	2264-2272	VBN	denotes	followed
T738	2273-2275	IN	denotes	by
T739	2276-2286	JJ	denotes	subsequent
T740	2287-2295	NN	denotes	mutation
T741	2295-2297	,	denotes	,
T742	2297-2310	NN	denotes	reduplication
T743	2311-2314	CC	denotes	and
T744	2315-2319	NN	denotes	exon
T745	2320-2329	NN	denotes	shuffling
T746	2330-2337	IN	denotes	between
T747	2338-2342	NN	denotes	gene
T748	2343-2351	NNS	denotes	families
T749	2351-2353	,	denotes	,
T750	2353-2358	NNS	denotes	genes
T751	2359-2363	VBP	denotes	have
T752	2372-2376	CC	denotes	both
T753	2377-2385	JJ	denotes	discrete
T754	2411-2420	NNS	denotes	functions
T755	2385-2387	,	denotes	,
T756	2387-2390	CC	denotes	and
T757	2391-2400	RB	denotes	partially
T758	2401-2410	JJ	denotes	redundant
T759	2421-2425	IN	denotes	with
T760	2426-2431	PRP$	denotes	their
T761	2447-2454	NNS	denotes	members
T762	2432-2439	VBN	denotes	related
T763	2440-2446	NN	denotes	family
T764	2454-2455	.	denotes	.
T765	2455-2680	sentence	denotes	With the completion of the genome sequencing projects of human, mouse, rat, fruit fly and nematodes, we are now in a position to ask fundamental questions in regard to how genes interact in the context of the whole organism.
T766	2456-2460	IN	denotes	With
T767	2560-2563	VBP	denotes	are
T768	2461-2464	DT	denotes	the
T769	2465-2475	NN	denotes	completion
T770	2476-2478	IN	denotes	of
T771	2479-2482	DT	denotes	the
T772	2501-2509	NNS	denotes	projects
T773	2483-2489	NN	denotes	genome
T774	2490-2500	NN	denotes	sequencing
T775	2510-2512	IN	denotes	of
T776	2513-2518	JJ	denotes	human
T777	2518-2520	,	denotes	,
T778	2520-2525	NN	denotes	mouse
T779	2525-2527	,	denotes	,
T780	2527-2530	NN	denotes	rat
T781	2530-2532	,	denotes	,
T782	2532-2537	NN	denotes	fruit
T783	2538-2541	NN	denotes	fly
T784	2542-2545	CC	denotes	and
T785	2546-2555	NNS	denotes	nematodes
T786	2555-2557	,	denotes	,
T787	2557-2559	PRP	denotes	we
T788	2564-2567	RB	denotes	now
T789	2568-2570	IN	denotes	in
T790	2571-2572	DT	denotes	a
T791	2573-2581	NN	denotes	position
T792	2582-2584	TO	denotes	to
T793	2585-2588	VB	denotes	ask
T794	2589-2600	JJ	denotes	fundamental
T795	2601-2610	NNS	denotes	questions
T796	2611-2613	IN	denotes	in
T797	2614-2620	NN	denotes	regard
T798	2621-2623	IN	denotes	to
T799	2624-2627	WRB	denotes	how
T800	2634-2642	VBP	denotes	interact
T801	2628-2633	NNS	denotes	genes
T802	2643-2645	IN	denotes	in
T803	2646-2649	DT	denotes	the
T804	2650-2657	NN	denotes	context
T805	2658-2660	IN	denotes	of
T806	2661-2664	DT	denotes	the
T807	2671-2679	NN	denotes	organism
T808	2665-2670	JJ	denotes	whole
T809	2679-2680	.	denotes	.
T810	2680-2864	sentence	denotes	Thus, with the appropriate application of bioinformatics, it is now possible to trace the lineage of particular genes and gene families, with related gene families in other organisms.
T811	2681-2685	RB	denotes	Thus
T812	2742-2744	VBZ	denotes	is
T813	2685-2687	,	denotes	,
T814	2687-2691	IN	denotes	with
T815	2692-2695	DT	denotes	the
T816	2708-2719	NN	denotes	application
T817	2696-2707	JJ	denotes	appropriate
T818	2720-2722	IN	denotes	of
T819	2723-2737	NN	denotes	bioinformatics
T820	2737-2739	,	denotes	,
T821	2739-2741	PRP	denotes	it
T822	2745-2748	RB	denotes	now
T823	2749-2757	JJ	denotes	possible
T824	2758-2760	TO	denotes	to
T825	2761-2766	VB	denotes	trace
T826	2767-2770	DT	denotes	the
T827	2771-2778	NN	denotes	lineage
T828	2779-2781	IN	denotes	of
T829	2782-2792	JJ	denotes	particular
T830	2793-2798	NNS	denotes	genes
T831	2799-2802	CC	denotes	and
T832	2803-2807	NN	denotes	gene
T833	2808-2816	NNS	denotes	families
T834	2816-2818	,	denotes	,
T835	2818-2822	IN	denotes	with
T836	2823-2830	JJ	denotes	related
T837	2836-2844	NNS	denotes	families
T838	2831-2835	NN	denotes	gene
T839	2845-2847	IN	denotes	in
T840	2848-2853	JJ	denotes	other
T841	2854-2863	NNS	denotes	organisms
T842	2863-2864	.	denotes	.
T843	2864-3096	sentence	denotes	Furthermore, with the growing amount of large-scale proteomic and genomic data becoming publicly available, this analysis can now be extended to reveal the complex interplay between evolution of gene structure and protein function.
T844	2865-2876	RB	denotes	Furthermore
T845	2998-3006	VBN	denotes	extended
T846	2876-2878	,	denotes	,
T847	2878-2882	IN	denotes	with
T848	2883-2886	DT	denotes	the
T849	2895-2901	NN	denotes	amount
T850	2887-2894	VBG	denotes	growing
T851	2944-2952	VBG	denotes	becoming
T852	2902-2904	IN	denotes	of
T853	2905-2910	JJ	denotes	large
T854	2911-2916	NN	denotes	scale
T855	2910-2911	HYPH	denotes	-
T856	2939-2943	NNS	denotes	data
T857	2917-2926	JJ	denotes	proteomic
T858	2927-2930	CC	denotes	and
T859	2931-2938	JJ	denotes	genomic
T860	2953-2961	RB	denotes	publicly
T861	2962-2971	JJ	denotes	available
T862	2971-2973	,	denotes	,
T863	2973-2977	DT	denotes	this
T864	2978-2986	NN	denotes	analysis
T865	2987-2990	MD	denotes	can
T866	2991-2994	RB	denotes	now
T867	2995-2997	VB	denotes	be
T868	3007-3009	TO	denotes	to
T869	3010-3016	VB	denotes	reveal
T870	3017-3020	DT	denotes	the
T871	3029-3038	NN	denotes	interplay
T872	3021-3028	JJ	denotes	complex
T873	3039-3046	IN	denotes	between
T874	3047-3056	NN	denotes	evolution
T875	3057-3059	IN	denotes	of
T876	3060-3064	NN	denotes	gene
T877	3065-3074	NN	denotes	structure
T878	3075-3078	CC	denotes	and
T879	3079-3086	NN	denotes	protein
T880	3087-3095	NN	denotes	function
T881	3095-3096	.	denotes	.
T882	3096-3263	sentence	denotes	The first Transforming acidic coiled coil gene, TACC1, was identified during the development of an expression map of the proximal short arm of human chromosome 8 [1].
T883	3097-3100	DT	denotes	The
T884	3139-3143	NN	denotes	gene
T885	3101-3106	JJ	denotes	first
T886	3107-3119	NN	denotes	Transforming
T887	3120-3126	JJ	denotes	acidic
T888	3127-3133	VBN	denotes	coiled
T889	3134-3138	NN	denotes	coil
T890	3156-3166	VBN	denotes	identified
T891	3143-3145	,	denotes	,
T892	3145-3150	NN	denotes	TACC1
T893	3150-3152	,	denotes	,
T894	3152-3155	VBD	denotes	was
T895	3167-3173	IN	denotes	during
T896	3174-3177	DT	denotes	the
T897	3178-3189	NN	denotes	development
T898	3190-3192	IN	denotes	of
T899	3193-3195	DT	denotes	an
T900	3207-3210	NN	denotes	map
T901	3196-3206	NN	denotes	expression
T902	3211-3213	IN	denotes	of
T903	3214-3217	DT	denotes	the
T904	3233-3236	NN	denotes	arm
T905	3218-3226	JJ	denotes	proximal
T906	3227-3232	JJ	denotes	short
T907	3237-3239	IN	denotes	of
T908	3240-3245	JJ	denotes	human
T909	3246-3256	NN	denotes	chromosome
T910	3257-3258	CD	denotes	8
T911	3259-3260	-LRB-	denotes	[
T912	3260-3261	CD	denotes	1
T913	3261-3262	-RRB-	denotes	]
T914	3262-3263	.	denotes	.
T915	3263-3468	sentence	denotes	Two additional TACC family members were subsequently identified and mapped to paralogous chromosomal regions on human chromosomes 4p16 and 10q26, physically close to members of the FGFR gene family [1-3].
T916	3264-3267	CD	denotes	Two
T917	3291-3298	NNS	denotes	members
T918	3268-3278	JJ	denotes	additional
T919	3279-3283	NN	denotes	TACC
T920	3284-3290	NN	denotes	family
T921	3317-3327	VBN	denotes	identified
T922	3299-3303	VBD	denotes	were
T923	3304-3316	RB	denotes	subsequently
T924	3328-3331	CC	denotes	and
T925	3332-3338	VBN	denotes	mapped
T926	3339-3341	IN	denotes	to
T927	3342-3352	JJ	denotes	paralogous
T928	3365-3372	NNS	denotes	regions
T929	3353-3364	JJ	denotes	chromosomal
T930	3373-3375	IN	denotes	on
T931	3376-3381	JJ	denotes	human
T932	3394-3398	NN	denotes	4p16
T933	3382-3393	NNS	denotes	chromosomes
T934	3399-3402	CC	denotes	and
T935	3403-3408	NN	denotes	10q26
T936	3408-3410	,	denotes	,
T937	3410-3420	RB	denotes	physically
T938	3421-3426	JJ	denotes	close
T939	3427-3429	IN	denotes	to
T940	3430-3437	NNS	denotes	members
T941	3438-3440	IN	denotes	of
T942	3441-3444	DT	denotes	the
T943	3455-3461	NN	denotes	family
T944	3445-3449	NN	denotes	FGFR
T945	3450-3454	NN	denotes	gene
T946	3462-3463	-LRB-	denotes	[
T947	3463-3464	CD	denotes	1
T948	3464-3465	SYM	denotes	-
T949	3465-3466	CD	denotes	3
T950	3466-3467	-RRB-	denotes	]
T951	3467-3468	.	denotes	.
T952	3468-3722	sentence	denotes	This mapping data, together with identification of a single TACC gene in the protostomes Caenorhabitis elegans, and Drosophila melanogaster [4-6], led to the speculation that the ancestral FGFR and TACC genes were located physically close to each other.
T953	3469-3473	DT	denotes	This
T954	3482-3486	NNS	denotes	data
T955	3474-3481	NN	denotes	mapping
T956	3616-3619	VBD	denotes	led
T957	3486-3488	,	denotes	,
T958	3488-3496	RB	denotes	together
T959	3497-3501	IN	denotes	with
T960	3502-3516	NN	denotes	identification
T961	3517-3519	IN	denotes	of
T962	3520-3521	DT	denotes	a
T963	3534-3538	NN	denotes	gene
T964	3522-3528	JJ	denotes	single
T965	3529-3533	NN	denotes	TACC
T966	3539-3541	IN	denotes	in
T967	3542-3545	DT	denotes	the
T968	3572-3579	NNP	denotes	elegans
T969	3546-3557	NNS	denotes	protostomes
T970	3558-3571	NNP	denotes	Caenorhabitis
T971	3579-3581	,	denotes	,
T972	3581-3584	CC	denotes	and
T973	3585-3595	NNP	denotes	Drosophila
T974	3596-3608	NNP	denotes	melanogaster
T975	3609-3610	-LRB-	denotes	[
T976	3610-3611	CD	denotes	4
T977	3611-3612	SYM	denotes	-
T978	3612-3613	CD	denotes	6
T979	3613-3614	-RRB-	denotes	]
T980	3614-3616	,	denotes	,
T981	3620-3622	IN	denotes	to
T982	3623-3626	DT	denotes	the
T983	3627-3638	NN	denotes	speculation
T984	3639-3643	IN	denotes	that
T985	3683-3690	VBN	denotes	located
T986	3644-3647	DT	denotes	the
T987	3672-3677	NNS	denotes	genes
T988	3648-3657	JJ	denotes	ancestral
T989	3658-3662	NN	denotes	FGFR
T990	3663-3666	CC	denotes	and
T991	3667-3671	NN	denotes	TACC
T992	3678-3682	VBD	denotes	were
T993	3691-3701	RB	denotes	physically
T994	3702-3707	RB	denotes	close
T995	3708-3710	IN	denotes	to
T996	3711-3715	DT	denotes	each
T997	3716-3721	JJ	denotes	other
T998	3721-3722	.	denotes	.
T999	3722-3914	sentence	denotes	Thus, during the evolution of vertebrates, subsequent successive duplications of the ancestral gene cluster have given rise to three TACC family members located close to FGFR genes in humans.
T1000	3723-3727	RB	denotes	Thus
T1001	3836-3841	VBN	denotes	given
T1002	3727-3729	,	denotes	,
T1003	3729-3735	IN	denotes	during
T1004	3736-3739	DT	denotes	the
T1005	3740-3749	NN	denotes	evolution
T1006	3750-3752	IN	denotes	of
T1007	3753-3764	NNS	denotes	vertebrates
T1008	3764-3766	,	denotes	,
T1009	3766-3776	JJ	denotes	subsequent
T1010	3788-3800	NNS	denotes	duplications
T1011	3777-3787	JJ	denotes	successive
T1012	3801-3803	IN	denotes	of
T1013	3804-3807	DT	denotes	the
T1014	3823-3830	NN	denotes	cluster
T1015	3808-3817	JJ	denotes	ancestral
T1016	3818-3822	NN	denotes	gene
T1017	3831-3835	VBP	denotes	have
T1018	3842-3846	NN	denotes	rise
T1019	3847-3849	IN	denotes	to
T1020	3850-3855	CD	denotes	three
T1021	3868-3875	NNS	denotes	members
T1022	3856-3860	NN	denotes	TACC
T1023	3861-3867	NN	denotes	family
T1024	3876-3883	VBN	denotes	located
T1025	3884-3889	RB	denotes	close
T1026	3890-3892	IN	denotes	to
T1027	3893-3897	NN	denotes	FGFR
T1028	3898-3903	NNS	denotes	genes
T1029	3904-3906	IN	denotes	in
T1030	3907-3913	NNS	denotes	humans
T1031	3913-3914	.	denotes	.
T1032	3914-4157	sentence	denotes	In accordance with the proposed quadruplication of the vertebrate genome during evolution, there is a fourth FGFR family member in vertebrates, raising the question of whether a fourth TACC gene is associated with FGFR4 in vertebrate genomes.
T1033	3915-3917	IN	denotes	In
T1034	4012-4014	VBZ	denotes	is
T1035	3918-3928	NN	denotes	accordance
T1036	3929-3933	IN	denotes	with
T1037	3934-3937	DT	denotes	the
T1038	3947-3962	NN	denotes	quadruplication
T1039	3938-3946	VBN	denotes	proposed
T1040	3963-3965	IN	denotes	of
T1041	3966-3969	DT	denotes	the
T1042	3981-3987	NN	denotes	genome
T1043	3970-3980	NN	denotes	vertebrate
T1044	3988-3994	IN	denotes	during
T1045	3995-4004	NN	denotes	evolution
T1046	4004-4006	,	denotes	,
T1047	4006-4011	EX	denotes	there
T1048	4015-4016	DT	denotes	a
T1049	4036-4042	NN	denotes	member
T1050	4017-4023	JJ	denotes	fourth
T1051	4024-4028	NN	denotes	FGFR
T1052	4029-4035	NN	denotes	family
T1053	4043-4045	IN	denotes	in
T1054	4046-4057	NNS	denotes	vertebrates
T1055	4057-4059	,	denotes	,
T1056	4059-4066	VBG	denotes	raising
T1057	4067-4070	DT	denotes	the
T1058	4071-4079	NN	denotes	question
T1059	4080-4082	IN	denotes	of
T1060	4083-4090	IN	denotes	whether
T1061	4113-4123	VBN	denotes	associated
T1062	4091-4092	DT	denotes	a
T1063	4105-4109	NN	denotes	gene
T1064	4093-4099	JJ	denotes	fourth
T1065	4100-4104	NN	denotes	TACC
T1066	4110-4112	VBZ	denotes	is
T1067	4124-4128	IN	denotes	with
T1068	4129-4134	NN	denotes	FGFR4
T1069	4135-4137	IN	denotes	in
T1070	4138-4148	NN	denotes	vertebrate
T1071	4149-4156	NNS	denotes	genomes
T1072	4156-4157	.	denotes	.
T1073	4157-4318	sentence	denotes	To date, only three active TACC genes have been cloned in humans [1-3], one in each of mouse [7], Xenopus laevis [8], D. melanogaster [4], and C. elegans [5,6].
T1074	4158-4160	IN	denotes	To
T1075	4230-4233	CD	denotes	one
T1076	4161-4165	NN	denotes	date
T1077	4165-4167	,	denotes	,
T1078	4167-4171	RB	denotes	only
T1079	4190-4195	NNS	denotes	genes
T1080	4172-4177	CD	denotes	three
T1081	4178-4184	JJ	denotes	active
T1082	4185-4189	NN	denotes	TACC
T1083	4206-4212	VBN	denotes	cloned
T1084	4196-4200	VBP	denotes	have
T1085	4201-4205	VBN	denotes	been
T1086	4213-4215	IN	denotes	in
T1087	4216-4222	NNS	denotes	humans
T1088	4223-4224	-LRB-	denotes	[
T1089	4224-4225	CD	denotes	1
T1090	4225-4226	SYM	denotes	-
T1091	4226-4227	CD	denotes	3
T1092	4227-4228	-RRB-	denotes	]
T1093	4228-4230	,	denotes	,
T1094	4234-4236	IN	denotes	in
T1095	4237-4241	DT	denotes	each
T1096	4242-4244	IN	denotes	of
T1097	4245-4250	NN	denotes	mouse
T1098	4251-4252	-LRB-	denotes	[
T1099	4252-4253	CD	denotes	7
T1100	4253-4254	-RRB-	denotes	]
T1101	4254-4256	,	denotes	,
T1102	4256-4263	NNP	denotes	Xenopus
T1103	4264-4270	NNP	denotes	laevis
T1104	4271-4272	-LRB-	denotes	[
T1105	4272-4273	CD	denotes	8
T1106	4273-4274	-RRB-	denotes	]
T1107	4274-4276	,	denotes	,
T1108	4276-4278	NNP	denotes	D.
T1109	4279-4291	NNP	denotes	melanogaster
T1110	4292-4293	-LRB-	denotes	[
T1111	4293-4294	CD	denotes	4
T1112	4294-4295	-RRB-	denotes	]
T1113	4295-4297	,	denotes	,
T1114	4297-4300	CC	denotes	and
T1115	4301-4303	NNP	denotes	C.
T1116	4304-4311	NNP	denotes	elegans
T1117	4312-4313	-LRB-	denotes	[
T1118	4315-4316	CD	denotes	6
T1119	4313-4314	CD	denotes	5
T1120	4314-4315	,	denotes	,
T1121	4316-4317	-RRB-	denotes	]
T1122	4317-4318	.	denotes	.
T1123	4318-4537	sentence	denotes	Although two additional new candidate TACC family members, Oryctolagus cuniculus TACC4 [9] and human RHAMM [10] have been proposed, their true identity and placement in the evolution of the TACC family is under debate.
T1124	4319-4327	IN	denotes	Although
T1125	4441-4449	VBN	denotes	proposed
T1126	4328-4331	CD	denotes	two
T1127	4369-4376	NNS	denotes	members
T1128	4332-4342	JJ	denotes	additional
T1129	4343-4346	JJ	denotes	new
T1130	4347-4356	NN	denotes	candidate
T1131	4357-4361	NN	denotes	TACC
T1132	4362-4368	NN	denotes	family
T1133	4376-4378	,	denotes	,
T1134	4378-4389	NNP	denotes	Oryctolagus
T1135	4400-4405	NN	denotes	TACC4
T1136	4390-4399	NNP	denotes	cuniculus
T1137	4406-4407	-LRB-	denotes	[
T1138	4407-4408	CD	denotes	9
T1139	4408-4409	-RRB-	denotes	]
T1140	4410-4413	CC	denotes	and
T1141	4414-4419	JJ	denotes	human
T1142	4420-4425	NN	denotes	RHAMM
T1143	4426-4427	-LRB-	denotes	[
T1144	4427-4429	CD	denotes	10
T1145	4429-4430	-RRB-	denotes	]
T1146	4431-4435	VBP	denotes	have
T1147	4436-4440	VBN	denotes	been
T1148	4521-4523	VBZ	denotes	is
T1149	4449-4451	,	denotes	,
T1150	4451-4456	PRP$	denotes	their
T1151	4462-4470	NN	denotes	identity
T1152	4457-4461	JJ	denotes	true
T1153	4471-4474	CC	denotes	and
T1154	4475-4484	NN	denotes	placement
T1155	4485-4487	IN	denotes	in
T1156	4488-4491	DT	denotes	the
T1157	4492-4501	NN	denotes	evolution
T1158	4502-4504	IN	denotes	of
T1159	4505-4508	DT	denotes	the
T1160	4514-4520	NN	denotes	family
T1161	4509-4513	NN	denotes	TACC
T1162	4524-4529	IN	denotes	under
T1163	4530-4536	NN	denotes	debate
T1164	4536-4537	.	denotes	.
T1165	4537-4889	sentence	denotes	Thus, the identification and functional characterization of new members of the TACC family in other organisms, alternatively spliced isoforms of each TACC and comparison of the phylogenetic relationship of these genes relative to other members of the coiled coil superfamily will resolve this issue and provide clues to the evolution of TACC function.
T1166	4538-4542	RB	denotes	Thus
T1167	4818-4825	VB	denotes	resolve
T1168	4542-4544	,	denotes	,
T1169	4544-4547	DT	denotes	the
T1170	4548-4562	NN	denotes	identification
T1171	4563-4566	CC	denotes	and
T1172	4567-4577	JJ	denotes	functional
T1173	4578-4594	NN	denotes	characterization
T1174	4595-4597	IN	denotes	of
T1175	4598-4601	JJ	denotes	new
T1176	4602-4609	NNS	denotes	members
T1177	4610-4612	IN	denotes	of
T1178	4613-4616	DT	denotes	the
T1179	4622-4628	NN	denotes	family
T1180	4617-4621	NN	denotes	TACC
T1181	4629-4631	IN	denotes	in
T1182	4632-4637	JJ	denotes	other
T1183	4638-4647	NNS	denotes	organisms
T1184	4647-4649	,	denotes	,
T1185	4649-4662	RB	denotes	alternatively
T1186	4663-4670	VBN	denotes	spliced
T1187	4671-4679	NNS	denotes	isoforms
T1188	4680-4682	IN	denotes	of
T1189	4683-4687	DT	denotes	each
T1190	4688-4692	NN	denotes	TACC
T1191	4693-4696	CC	denotes	and
T1192	4697-4707	NN	denotes	comparison
T1193	4708-4710	IN	denotes	of
T1194	4711-4714	DT	denotes	the
T1195	4728-4740	NN	denotes	relationship
T1196	4715-4727	JJ	denotes	phylogenetic
T1197	4741-4743	IN	denotes	of
T1198	4744-4749	DT	denotes	these
T1199	4750-4755	NNS	denotes	genes
T1200	4756-4764	JJ	denotes	relative
T1201	4765-4767	IN	denotes	to
T1202	4768-4773	JJ	denotes	other
T1203	4774-4781	NNS	denotes	members
T1204	4782-4784	IN	denotes	of
T1205	4785-4788	DT	denotes	the
T1206	4801-4812	NN	denotes	superfamily
T1207	4789-4795	VBN	denotes	coiled
T1208	4796-4800	NN	denotes	coil
T1209	4813-4817	MD	denotes	will
T1210	4826-4830	DT	denotes	this
T1211	4831-4836	NN	denotes	issue
T1212	4837-4840	CC	denotes	and
T1213	4841-4848	VB	denotes	provide
T1214	4849-4854	NNS	denotes	clues
T1215	4855-4857	IN	denotes	to
T1216	4858-4861	DT	denotes	the
T1217	4862-4871	NN	denotes	evolution
T1218	4872-4874	IN	denotes	of
T1219	4875-4879	NN	denotes	TACC
T1220	4880-4888	NN	denotes	function
T1221	4888-4889	.	denotes	.
T1593	4915-4917	FW	denotes	In
T1594	4918-4924	FW	denotes	silico
T1595	4925-4939	NN	denotes	identification
T1596	4940-4942	IN	denotes	of
T1597	4943-4947	NN	denotes	TACC
T1598	4955-4962	NNS	denotes	members
T1599	4948-4954	NN	denotes	family
T1600	4963-4967	IN	denotes	from
T1601	4968-4978	NN	denotes	vertebrate
T1602	4996-5004	NNS	denotes	lineages
T1603	4979-4982	CC	denotes	and
T1604	4983-4995	NN	denotes	invertebrate
T1605	5004-5253	sentence	denotes	Sequence similarity searches of the publicly available genome databases with the BLAST and TBLAST programs were performed to identify TACC and RHAMM orthologues, and other members of the coiled coil superfamily in a diverse set of species (Fig. 1).
T1606	5005-5013	NN	denotes	Sequence
T1607	5014-5024	NN	denotes	similarity
T1608	5025-5033	NNS	denotes	searches
T1609	5117-5126	VBN	denotes	performed
T1610	5034-5036	IN	denotes	of
T1611	5037-5040	DT	denotes	the
T1612	5067-5076	NNS	denotes	databases
T1613	5041-5049	RB	denotes	publicly
T1614	5050-5059	JJ	denotes	available
T1615	5060-5066	NN	denotes	genome
T1616	5077-5081	IN	denotes	with
T1617	5082-5085	DT	denotes	the
T1618	5103-5111	NNS	denotes	programs
T1619	5086-5091	NN	denotes	BLAST
T1620	5092-5095	CC	denotes	and
T1621	5096-5102	NN	denotes	TBLAST
T1622	5112-5116	VBD	denotes	were
T1623	5127-5129	TO	denotes	to
T1624	5130-5138	VB	denotes	identify
T1625	5139-5143	NN	denotes	TACC
T1626	5154-5165	NNS	denotes	orthologues
T1627	5144-5147	CC	denotes	and
T1628	5148-5153	NN	denotes	RHAMM
T1629	5165-5167	,	denotes	,
T1630	5167-5170	CC	denotes	and
T1631	5171-5176	JJ	denotes	other
T1632	5177-5184	NNS	denotes	members
T1633	5185-5187	IN	denotes	of
T1634	5188-5191	DT	denotes	the
T1635	5204-5215	NN	denotes	superfamily
T1636	5192-5198	VBN	denotes	coiled
T1637	5199-5203	NN	denotes	coil
T1638	5216-5218	IN	denotes	in
T1639	5219-5220	DT	denotes	a
T1640	5229-5232	NN	denotes	set
T1641	5221-5228	JJ	denotes	diverse
T1642	5233-5235	IN	denotes	of
T1643	5236-5243	NNS	denotes	species
T1644	5244-5245	-LRB-	denotes	(
T1645	5245-5249	NN	denotes	Fig.
T1646	5250-5251	CD	denotes	1
T1647	5251-5252	-RRB-	denotes	)
T1648	5252-5253	.	denotes	.
T1649	5253-5376	sentence	denotes	This identified the complete sequence of the TACC genes in representatives of five major phylogenetically distinct clades.
T1650	5254-5258	DT	denotes	This
T1651	5259-5269	VBD	denotes	identified
T1652	5270-5273	DT	denotes	the
T1653	5283-5291	NN	denotes	sequence
T1654	5274-5282	JJ	denotes	complete
T1655	5292-5294	IN	denotes	of
T1656	5295-5298	DT	denotes	the
T1657	5304-5309	NNS	denotes	genes
T1658	5299-5303	NN	denotes	TACC
T1659	5310-5312	IN	denotes	in
T1660	5313-5328	NNS	denotes	representatives
T1661	5329-5331	IN	denotes	of
T1662	5332-5336	CD	denotes	five
T1663	5369-5375	NNS	denotes	clades
T1664	5337-5342	JJ	denotes	major
T1665	5343-5359	RB	denotes	phylogenetically
T1666	5360-5368	JJ	denotes	distinct
T1667	5375-5376	.	denotes	.
T1668	5376-5510	sentence	denotes	Where possible, the construction of the TACC sequences from these organisms was also confirmed by the analysis of the cDNA databases.
T1669	5377-5382	WRB	denotes	Where
T1670	5383-5391	JJ	denotes	possible
T1671	5462-5471	VBN	denotes	confirmed
T1672	5391-5393	,	denotes	,
T1673	5393-5396	DT	denotes	the
T1674	5397-5409	NN	denotes	construction
T1675	5410-5412	IN	denotes	of
T1676	5413-5416	DT	denotes	the
T1677	5422-5431	NNS	denotes	sequences
T1678	5417-5421	NN	denotes	TACC
T1679	5432-5436	IN	denotes	from
T1680	5437-5442	DT	denotes	these
T1681	5443-5452	NNS	denotes	organisms
T1682	5453-5456	VBD	denotes	was
T1683	5457-5461	RB	denotes	also
T1684	5472-5474	IN	denotes	by
T1685	5475-5478	DT	denotes	the
T1686	5479-5487	NN	denotes	analysis
T1687	5488-5490	IN	denotes	of
T1688	5491-5494	DT	denotes	the
T1689	5500-5509	NNS	denotes	databases
T1690	5495-5499	NN	denotes	cDNA
T1691	5509-5510	.	denotes	.
T1692	5510-5754	sentence	denotes	Several partial sequences in other vertebrate species, the echinodermate Strongylocentrotus purpuratus and the protostome insect Anopheles gambiae were also identified, suggesting an ancient conservation of the TACC genes in metazoan lineages.
T1693	5511-5518	JJ	denotes	Several
T1694	5527-5536	NNS	denotes	sequences
T1695	5519-5526	JJ	denotes	partial
T1696	5668-5678	VBN	denotes	identified
T1697	5537-5539	IN	denotes	in
T1698	5540-5545	JJ	denotes	other
T1699	5557-5564	NNS	denotes	species
T1700	5546-5556	NN	denotes	vertebrate
T1701	5564-5566	,	denotes	,
T1702	5566-5569	DT	denotes	the
T1703	5570-5583	JJ	denotes	echinodermate
T1704	5584-5602	NNP	denotes	Strongylocentrotus
T1705	5603-5613	NNP	denotes	purpuratus
T1706	5614-5617	CC	denotes	and
T1707	5618-5621	DT	denotes	the
T1708	5633-5639	NN	denotes	insect
T1709	5622-5632	NN	denotes	protostome
T1714	5678-5680	,	denotes	,
T1715	5680-5690	VBG	denotes	suggesting
T1716	5691-5693	DT	denotes	an
T1717	5702-5714	NN	denotes	conservation
T1718	5694-5701	JJ	denotes	ancient
T1719	5715-5717	IN	denotes	of
T1720	5718-5721	DT	denotes	the
T1721	5727-5732	NNS	denotes	genes
T1722	5722-5726	NN	denotes	TACC
T1723	5733-5735	IN	denotes	in
T1724	5736-5744	NN	denotes	metazoan
T1725	5745-5753	NNS	denotes	lineages
T1726	5753-5754	.	denotes	.
T1727	5754-5918	sentence	denotes	However, due to the relative infancy of the cDNA/genome projects for these latter organisms, complete characterization of these TACC genes could not be undertaken.
T1728	5755-5762	RB	denotes	However
T1729	5907-5917	VBN	denotes	undertaken
T1730	5762-5764	,	denotes	,
T1731	5764-5767	IN	denotes	due
T1732	5768-5770	IN	denotes	to
T1733	5771-5774	DT	denotes	the
T1734	5784-5791	NN	denotes	infancy
T1735	5775-5783	JJ	denotes	relative
T1736	5792-5794	IN	denotes	of
T1737	5795-5798	DT	denotes	the
T1738	5811-5819	NNS	denotes	projects
T1739	5799-5803	NN	denotes	cDNA
T1740	5804-5810	NN	denotes	genome
T1741	5803-5804	HYPH	denotes	/
T1742	5820-5823	IN	denotes	for
T1743	5824-5829	DT	denotes	these
T1744	5837-5846	NNS	denotes	organisms
T1745	5830-5836	JJ	denotes	latter
T1746	5846-5848	,	denotes	,
T1747	5848-5856	JJ	denotes	complete
T1748	5857-5873	NN	denotes	characterization
T1749	5874-5876	IN	denotes	of
T1750	5877-5882	DT	denotes	these
T1751	5888-5893	NNS	denotes	genes
T1752	5883-5887	NN	denotes	TACC
T1753	5894-5899	MD	denotes	could
T1754	5900-5903	RB	denotes	not
T1755	5904-5906	VB	denotes	be
T1756	5917-5918	.	denotes	.
T1757	5918-6226	sentence	denotes	No conclusion could be made about the existence of TACC-like sequence in non-bilaterian metazoans, such as Cnidaria or Porifera, due to the paucity of sequence information for these organisms, and additional definitive sequences with a defined TACC domain could not be found in other non-metazoan organisms.
T1758	5919-5921	DT	denotes	No
T1759	5922-5932	NN	denotes	conclusion
T1760	5942-5946	VBN	denotes	made
T1761	5933-5938	MD	denotes	could
T1762	5939-5941	VB	denotes	be
T1763	5947-5952	IN	denotes	about
T1764	5953-5956	DT	denotes	the
T1765	5957-5966	NN	denotes	existence
T1766	5967-5969	IN	denotes	of
T1767	5970-5974	NN	denotes	TACC
T1768	5975-5979	JJ	denotes	like
T1769	5974-5975	HYPH	denotes	-
T1770	5980-5988	NN	denotes	sequence
T1771	5989-5991	IN	denotes	in
T1772	5992-6006	JJ	denotes	non-bilaterian
T1773	6007-6016	NNS	denotes	metazoans
T1774	6016-6018	,	denotes	,
T1775	6018-6022	JJ	denotes	such
T1776	6023-6025	IN	denotes	as
T1777	6026-6034	NNP	denotes	Cnidaria
T1778	6035-6037	CC	denotes	or
T1779	6038-6046	NNP	denotes	Porifera
T1780	6046-6048	,	denotes	,
T1781	6048-6051	IN	denotes	due
T1782	6052-6054	IN	denotes	to
T1783	6055-6058	DT	denotes	the
T1784	6059-6066	NN	denotes	paucity
T1785	6067-6069	IN	denotes	of
T1786	6070-6078	NN	denotes	sequence
T1787	6079-6090	NN	denotes	information
T1788	6091-6094	IN	denotes	for
T1789	6095-6100	DT	denotes	these
T1790	6101-6110	NNS	denotes	organisms
T1791	6110-6112	,	denotes	,
T1792	6112-6115	CC	denotes	and
T1793	6116-6126	JJ	denotes	additional
T1794	6138-6147	NNS	denotes	sequences
T1795	6127-6137	JJ	denotes	definitive
T1796	6188-6193	VBN	denotes	found
T1797	6148-6152	IN	denotes	with
T1798	6153-6154	DT	denotes	a
T1799	6168-6174	NN	denotes	domain
T1800	6155-6162	VBN	denotes	defined
T1801	6163-6167	NN	denotes	TACC
T1802	6175-6180	MD	denotes	could
T1803	6181-6184	RB	denotes	not
T1804	6185-6187	VB	denotes	be
T1805	6194-6196	IN	denotes	in
T1806	6197-6202	JJ	denotes	other
T1807	6216-6225	NNS	denotes	organisms
T1808	6203-6215	JJ	denotes	non-metazoan
T1809	6225-6226	.	denotes	.
T1810	6226-6227	sentence	denotes
T1811	6719-6726	sentence	denotes	At the
T1851	6830-6835	NNP	denotes	Ciona
T1852	6836-6848	NNP	denotes	intestinalis
T1853	6849-6850	-LRB-	denotes	[
T1854	6850-6852	CD	denotes	11
T1855	6852-6853	-RRB-	denotes	]
T1856	6853-6855	,	denotes	,
T1857	6855-6858	CC	denotes	and
T1858	6859-6860	DT	denotes	a
T1859	6874-6882	NN	denotes	sequence
T1860	6861-6868	JJ	denotes	partial
T1861	6869-6873	NN	denotes	TACC
T1862	6883-6887	IN	denotes	from
T1863	6888-6890	DT	denotes	an
T1864	6891-6899	NN	denotes	analysis
T1865	6900-6902	IN	denotes	of
T1866	6903-6906	DT	denotes	the
T1867	6931-6939	NN	denotes	database
T1868	6907-6918	NNP	denotes	Halocynthia
T1869	6919-6926	NNP	denotes	rortezi
T1870	6927-6930	NN	denotes	EST
T1871	6940-6941	-LRB-	denotes	[
T1872	6941-6943	CD	denotes	12
T1873	6943-6944	-RRB-	denotes	]
T1874	6944-6945	.	denotes	.
T1875	6945-7045	sentence	denotes	This confirms the original assumption that a single TACC gene was present in the chordate ancestor.
T1876	6946-6950	DT	denotes	This
T1877	6951-6959	VBZ	denotes	confirms
T1878	6960-6963	DT	denotes	the
T1879	6973-6983	NN	denotes	assumption
T1880	6964-6972	JJ	denotes	original
T1881	6984-6988	IN	denotes	that
T1882	7008-7011	VBD	denotes	was
T1883	6989-6990	DT	denotes	a
T1884	7003-7007	NN	denotes	gene
T1885	6991-6997	JJ	denotes	single
T1886	6998-7002	NN	denotes	TACC
T1887	7012-7019	JJ	denotes	present
T1888	7020-7022	IN	denotes	in
T1889	7023-7026	DT	denotes	the
T1890	7036-7044	NN	denotes	ancestor
T1891	7027-7035	NN	denotes	chordate
T1892	7044-7045	.	denotes	.
T1893	7045-7285	sentence	denotes	The next major event in the evolution of the chordate genome has been suggested to have occurred 687 ± 155.7 million years ago (MYA), with the first duplication of the chordate genome, and a second duplication occurring shortly thereafter.
T1894	7046-7049	DT	denotes	The
T1895	7061-7066	NN	denotes	event
T1896	7050-7054	JJ	denotes	next
T1897	7055-7060	JJ	denotes	major
T1898	7116-7125	VBN	denotes	suggested
T1899	7067-7069	IN	denotes	in
T1900	7070-7073	DT	denotes	the
T1901	7074-7083	NN	denotes	evolution
T1902	7084-7086	IN	denotes	of
T1903	7087-7090	DT	denotes	the
T1904	7100-7106	NN	denotes	genome
T1905	7091-7099	NN	denotes	chordate
T1906	7107-7110	VBZ	denotes	has
T1907	7111-7115	VBN	denotes	been
T1908	7126-7128	TO	denotes	to
T1909	7134-7142	VBN	denotes	occurred
T1910	7129-7133	VB	denotes	have
T1911	7143-7146	CD	denotes	687
T1912	7149-7154	CD	denotes	155.7
T1913	7147-7148	SYM	denotes	±
T1914	7163-7168	NNS	denotes	years
T1915	7155-7162	CD	denotes	million
T1916	7169-7172	RB	denotes	ago
T1917	7173-7174	-LRB-	denotes	(
T1918	7174-7177	RB	denotes	MYA
T1919	7177-7178	-RRB-	denotes	)
T1920	7178-7180	,	denotes	,
T1921	7180-7184	IN	denotes	with
T1922	7185-7188	DT	denotes	the
T1923	7195-7206	NN	denotes	duplication
T1924	7189-7194	JJ	denotes	first
T1925	7207-7209	IN	denotes	of
T1926	7210-7213	DT	denotes	the
T1927	7223-7229	NN	denotes	genome
T1928	7214-7222	NN	denotes	chordate
T1929	7229-7231	,	denotes	,
T1930	7231-7234	CC	denotes	and
T1931	7235-7236	DT	denotes	a
T1932	7244-7255	NN	denotes	duplication
T1933	7237-7243	JJ	denotes	second
T1934	7256-7265	VBG	denotes	occurring
T1935	7266-7273	RB	denotes	shortly
T1936	7274-7284	RB	denotes	thereafter
T1937	7284-7285	.	denotes	.
T1938	7285-7724	sentence	denotes	Thus, if the TACC genes were duplicated at both events, we would expect to identify four TACC genes in the most "primitive" compact vertebrate genome sequenced to date, the pufferfish Takifugu rubripes, with three genes corresponding to the human TACC1-3, and, in keeping with the proposed model for genomic duplication of the chromosomal loci for the TACC genes (discussed below), a possible fourth gene deriving from the TACC3 ancestor.
T1939	7286-7290	RB	denotes	Thus
T1940	7351-7357	VB	denotes	expect
T1941	7290-7292	,	denotes	,
T1942	7292-7294	IN	denotes	if
T1943	7315-7325	VBN	denotes	duplicated
T1944	7295-7298	DT	denotes	the
T1945	7304-7309	NNS	denotes	genes
T1946	7299-7303	NN	denotes	TACC
T1947	7310-7314	VBD	denotes	were
T1948	7326-7328	IN	denotes	at
T1949	7329-7333	DT	denotes	both
T1950	7334-7340	NNS	denotes	events
T1951	7340-7342	,	denotes	,
T1952	7342-7344	PRP	denotes	we
T1953	7345-7350	MD	denotes	would
T1954	7358-7360	TO	denotes	to
T1955	7361-7369	VB	denotes	identify
T1956	7370-7374	CD	denotes	four
T1957	7380-7385	NNS	denotes	genes
T1958	7375-7379	NN	denotes	TACC
T1959	7386-7388	IN	denotes	in
T1960	7389-7392	DT	denotes	the
T1961	7429-7435	NN	denotes	genome
T1962	7393-7397	JJS	denotes	most
T1963	7399-7408	JJ	denotes	primitive
T1964	7398-7399	``	denotes	"
T1965	7408-7409	''	denotes	"
T1966	7410-7417	JJ	denotes	compact
T1967	7418-7428	NN	denotes	vertebrate
T1968	7436-7445	VBN	denotes	sequenced
T1969	7446-7448	IN	denotes	to
T1970	7449-7453	NN	denotes	date
T1971	7453-7455	,	denotes	,
T1972	7455-7458	DT	denotes	the
T1973	7459-7469	NN	denotes	pufferfish
T1974	7470-7478	NNP	denotes	Takifugu
T1975	7479-7487	NNP	denotes	rubripes
T1976	7487-7489	,	denotes	,
T1977	7489-7493	IN	denotes	with
T1978	7494-7499	CD	denotes	three
T1979	7500-7505	NNS	denotes	genes
T1980	7506-7519	VBG	denotes	corresponding
T1981	7520-7522	IN	denotes	to
T1982	7523-7526	DT	denotes	the
T1983	7533-7538	NN	denotes	TACC1
T1984	7527-7532	JJ	denotes	human
T1985	7538-7539	HYPH	denotes	-
T1986	7539-7540	CD	denotes	3
T1987	7540-7542	,	denotes	,
T1988	7542-7545	CC	denotes	and
T1989	7545-7547	,	denotes	,
T1990	7547-7549	IN	denotes	in
T1991	7686-7690	NN	denotes	gene
T1992	7550-7557	VBG	denotes	keeping
T1993	7558-7562	IN	denotes	with
T1994	7563-7566	DT	denotes	the
T1995	7576-7581	NN	denotes	model
T1996	7567-7575	VBN	denotes	proposed
T1997	7582-7585	IN	denotes	for
T1998	7586-7593	JJ	denotes	genomic
T1999	7594-7605	NN	denotes	duplication
T2000	7606-7608	IN	denotes	of
T2001	7609-7612	DT	denotes	the
T2002	7625-7629	NNS	denotes	loci
T2003	7613-7624	JJ	denotes	chromosomal
T2004	7630-7633	IN	denotes	for
T2005	7634-7637	DT	denotes	the
T2006	7643-7648	NNS	denotes	genes
T2007	7638-7642	NN	denotes	TACC
T2008	7649-7650	-LRB-	denotes	(
T2009	7650-7659	VBN	denotes	discussed
T2010	7660-7665	RB	denotes	below
T2011	7665-7666	-RRB-	denotes	)
T2012	7666-7668	,	denotes	,
T2013	7668-7669	DT	denotes	a
T2014	7670-7678	JJ	denotes	possible
T2015	7679-7685	JJ	denotes	fourth
T2016	7691-7699	VBG	denotes	deriving
T2017	7700-7704	IN	denotes	from
T2018	7705-7708	DT	denotes	the
T2019	7715-7723	NN	denotes	ancestor
T2020	7709-7714	NN	denotes	TACC3
T2021	7723-7724	.	denotes	.
T2022	7724-7780	sentence	denotes	Indeed, four TACC genes were identified in T. rubripes.
T2023	7725-7731	RB	denotes	Indeed
T2024	7754-7764	VBN	denotes	identified
T2025	7731-7733	,	denotes	,
T2026	7733-7737	CD	denotes	four
T2027	7743-7748	NNS	denotes	genes
T2028	7738-7742	NN	denotes	TACC
T2029	7749-7753	VBD	denotes	were
T2030	7765-7767	IN	denotes	in
T2031	7768-7770	NNP	denotes	T.
T2032	7771-7779	NNP	denotes	rubripes
T2033	7779-7780	.	denotes	.
T2034	7780-7870	sentence	denotes	Of these, two genes corresponded to the T. rubripes orthologues of human TACC2 and TACC3.
T2035	7781-7783	IN	denotes	Of
T2036	7801-7813	VBD	denotes	corresponded
T2037	7784-7789	DT	denotes	these
T2038	7789-7791	,	denotes	,
T2039	7791-7794	CD	denotes	two
T2040	7795-7800	NNS	denotes	genes
T2041	7814-7816	IN	denotes	to
T2042	7817-7820	DT	denotes	the
T2043	7833-7844	NNS	denotes	orthologues
T2044	7821-7823	NNP	denotes	T.
T2045	7824-7832	NNP	denotes	rubripes
T2046	7845-7847	IN	denotes	of
T2047	7848-7853	JJ	denotes	human
T2048	7854-7859	NN	denotes	TACC2
T2049	7860-7863	CC	denotes	and
T2050	7864-7869	NN	denotes	TACC3
T2051	7869-7870	.	denotes	.
T2052	7870-7966	sentence	denotes	However, the other two genes, trTACC1A and trTACC1B are clearly most related to TACC1 (Fig. 1).
T2053	7871-7878	RB	denotes	However
T2054	7923-7926	VBP	denotes	are
T2055	7878-7880	,	denotes	,
T2056	7880-7883	DT	denotes	the
T2057	7894-7899	NNS	denotes	genes
T2058	7884-7889	JJ	denotes	other
T2059	7890-7893	CD	denotes	two
T2060	7899-7901	,	denotes	,
T2061	7901-7909	NN	denotes	trTACC1A
T2062	7910-7913	CC	denotes	and
T2063	7914-7922	NN	denotes	trTACC1B
T2064	7927-7934	RB	denotes	clearly
T2065	7935-7939	RBS	denotes	most
T2066	7940-7947	JJ	denotes	related
T2067	7948-7950	IN	denotes	to
T2068	7951-7956	NN	denotes	TACC1
T2069	7957-7958	-LRB-	denotes	(
T2070	7958-7962	NN	denotes	Fig.
T2071	7963-7964	CD	denotes	1
T2072	7964-7965	-RRB-	denotes	)
T2073	7965-7966	.	denotes	.
T2074	7966-8080	sentence	denotes	Although trTACC1A is highly homologous to trTACC1B, the latter encodes a significantly smaller predicted protein.
T2075	7967-7975	IN	denotes	Although
T2076	7985-7987	VBZ	denotes	is
T2077	7976-7984	NN	denotes	trTACC1A
T2078	8030-8037	VBZ	denotes	encodes
T2079	7988-7994	RB	denotes	highly
T2080	7995-8005	JJ	denotes	homologous
T2081	8006-8008	IN	denotes	to
T2082	8009-8017	NN	denotes	trTACC1B
T2083	8017-8019	,	denotes	,
T2084	8019-8022	DT	denotes	the
T2085	8023-8029	JJ	denotes	latter
T2086	8038-8039	DT	denotes	a
T2087	8072-8079	NN	denotes	protein
T2088	8040-8053	RB	denotes	significantly
T2089	8054-8061	JJR	denotes	smaller
T2090	8062-8071	VBN	denotes	predicted
T2091	8079-8080	.	denotes	.
T2092	8080-8187	sentence	denotes	The trTACC1B gene is encoded by 15 exons over approximately 7 kb of the Takifugu Scaffold 191 (see below).
T2093	8081-8084	DT	denotes	The
T2094	8094-8098	NN	denotes	gene
T2095	8085-8093	NN	denotes	trTACC1B
T2096	8102-8109	VBN	denotes	encoded
T2097	8099-8101	VBZ	denotes	is
T2098	8110-8112	IN	denotes	by
T2099	8113-8115	CD	denotes	15
T2100	8116-8121	NNS	denotes	exons
T2101	8122-8126	IN	denotes	over
T2102	8127-8140	RB	denotes	approximately
T2103	8141-8142	CD	denotes	7
T2104	8143-8145	NN	denotes	kb
T2105	8146-8148	IN	denotes	of
T2106	8149-8152	DT	denotes	the
T2107	8162-8170	NNP	denotes	Scaffold
T2108	8153-8161	NNP	denotes	Takifugu
T2109	8171-8174	CD	denotes	191
T2110	8175-8176	-LRB-	denotes	(
T2111	8176-8179	VB	denotes	see
T2112	8180-8185	RB	denotes	below
T2113	8185-8186	-RRB-	denotes	)
T2114	8186-8187	.	denotes	.
T2115	8187-8328	sentence	denotes	A search of this region using the trTACC1A sequence and gene prediction software has so far failed to identify additional exons of trTACC1B.
T2116	8188-8189	DT	denotes	A
T2117	8190-8196	NN	denotes	search
T2118	8280-8286	VBN	denotes	failed
T2119	8197-8199	IN	denotes	of
T2120	8200-8204	DT	denotes	this
T2121	8205-8211	NN	denotes	region
T2122	8212-8217	VBG	denotes	using
T2123	8218-8221	DT	denotes	the
T2124	8260-8268	NN	denotes	software
T2125	8222-8230	NN	denotes	trTACC1A
T2126	8231-8239	NN	denotes	sequence
T2127	8240-8243	CC	denotes	and
T2128	8244-8248	NN	denotes	gene
T2129	8249-8259	NN	denotes	prediction
T2130	8269-8272	VBZ	denotes	has
T2131	8273-8275	RB	denotes	so
T2132	8276-8279	RB	denotes	far
T2133	8287-8289	TO	denotes	to
T2134	8290-8298	VB	denotes	identify
T2135	8299-8309	JJ	denotes	additional
T2136	8310-8315	NNS	denotes	exons
T2137	8316-8318	IN	denotes	of
T2138	8319-8327	NN	denotes	trTACC1B
T2139	8327-8328	.	denotes	.
T2140	8328-8625	sentence	denotes	However, given the intron/exon structure of this apparently complete gene, it appears likely that trTACC1B is active in the pufferfish, and presumably fulfils either a temporal-spatial specific function within the organism, or a distinct function from the larger trTACC1A product within the cell.
T2141	8329-8336	RB	denotes	However
T2142	8407-8414	VBZ	denotes	appears
T2143	8336-8338	,	denotes	,
T2144	8338-8343	VBN	denotes	given
T2145	8344-8347	DT	denotes	the
T2146	8360-8369	NN	denotes	structure
T2147	8348-8354	NN	denotes	intron
T2148	8355-8359	NN	denotes	exon
T2149	8354-8355	HYPH	denotes	/
T2150	8370-8372	IN	denotes	of
T2151	8373-8377	DT	denotes	this
T2152	8398-8402	NN	denotes	gene
T2153	8378-8388	RB	denotes	apparently
T2154	8389-8397	JJ	denotes	complete
T2155	8402-8404	,	denotes	,
T2156	8404-8406	PRP	denotes	it
T2157	8415-8421	JJ	denotes	likely
T2158	8422-8426	IN	denotes	that
T2159	8436-8438	VBZ	denotes	is
T2160	8427-8435	NN	denotes	trTACC1B
T2161	8439-8445	JJ	denotes	active
T2162	8446-8448	IN	denotes	in
T2163	8449-8452	DT	denotes	the
T2164	8453-8463	NN	denotes	pufferfish
T2165	8463-8465	,	denotes	,
T2166	8465-8468	CC	denotes	and
T2167	8469-8479	RB	denotes	presumably
T2168	8480-8487	VBZ	denotes	fulfils
T2169	8488-8494	CC	denotes	either
T2170	8523-8531	NN	denotes	function
T2171	8495-8496	DT	denotes	a
T2172	8497-8505	JJ	denotes	temporal
T2173	8506-8513	JJ	denotes	spatial
T2174	8505-8506	HYPH	denotes	-
T2175	8514-8522	JJ	denotes	specific
T2176	8532-8538	IN	denotes	within
T2177	8539-8542	DT	denotes	the
T2178	8543-8551	NN	denotes	organism
T2179	8551-8553	,	denotes	,
T2180	8553-8555	CC	denotes	or
T2181	8556-8557	DT	denotes	a
T2182	8567-8575	NN	denotes	function
T2183	8558-8566	JJ	denotes	distinct
T2184	8576-8580	IN	denotes	from
T2185	8581-8584	DT	denotes	the
T2186	8601-8608	NN	denotes	product
T2187	8585-8591	JJR	denotes	larger
T2188	8592-8600	NN	denotes	trTACC1A
T2189	8609-8615	IN	denotes	within
T2190	8616-8619	DT	denotes	the
T2191	8620-8624	NN	denotes	cell
T2192	8624-8625	.	denotes	.
T2193	8625-8917	sentence	denotes	Thus, based upon the surrounding chromosomal loci (see below), the trTACC1A and trTACC1B genes appear to have arisen from the duplication of the chromosomal segment containing the teleost TACC1 ancestor, during the additional partial genomic duplication that occurred in the teleost lineage.
T2194	8626-8630	RB	denotes	Thus
T2195	8721-8727	VBP	denotes	appear
T2196	8630-8632	,	denotes	,
T2197	8632-8637	VBN	denotes	based
T2198	8638-8642	IN	denotes	upon
T2199	8643-8646	DT	denotes	the
T2200	8671-8675	NNS	denotes	loci
T2201	8647-8658	VBG	denotes	surrounding
T2202	8659-8670	JJ	denotes	chromosomal
T2203	8676-8677	-LRB-	denotes	(
T2204	8677-8680	VB	denotes	see
T2205	8681-8686	RB	denotes	below
T2206	8686-8687	-RRB-	denotes	)
T2207	8687-8689	,	denotes	,
T2208	8689-8692	DT	denotes	the
T2209	8715-8720	NNS	denotes	genes
T2210	8693-8701	NN	denotes	trTACC1A
T2211	8702-8705	CC	denotes	and
T2212	8706-8714	NN	denotes	trTACC1B
T2213	8728-8730	TO	denotes	to
T2214	8736-8742	VBN	denotes	arisen
T2215	8731-8735	VB	denotes	have
T2216	8743-8747	IN	denotes	from
T2217	8748-8751	DT	denotes	the
T2218	8752-8763	NN	denotes	duplication
T2219	8764-8766	IN	denotes	of
T2220	8767-8770	DT	denotes	the
T2221	8783-8790	NN	denotes	segment
T2222	8771-8782	JJ	denotes	chromosomal
T2223	8791-8801	VBG	denotes	containing
T2224	8802-8805	DT	denotes	the
T2225	8820-8828	NN	denotes	ancestor
T2226	8806-8813	NN	denotes	teleost
T2227	8814-8819	NN	denotes	TACC1
T2228	8828-8830	,	denotes	,
T2229	8830-8836	IN	denotes	during
T2230	8837-8840	DT	denotes	the
T2231	8868-8879	NN	denotes	duplication
T2232	8841-8851	JJ	denotes	additional
T2233	8852-8859	JJ	denotes	partial
T2234	8860-8867	JJ	denotes	genomic
T2235	8880-8884	WDT	denotes	that
T2236	8885-8893	VBD	denotes	occurred
T2237	8894-8896	IN	denotes	in
T2238	8897-8900	DT	denotes	the
T2239	8909-8916	NN	denotes	lineage
T2240	8901-8908	NN	denotes	teleost
T2241	8916-8917	.	denotes	.
T2242	8917-9104	sentence	denotes	Therefore, this analysis of T. rubripes does not support the hypothesis that the region surrounding the TACC3 ancestor was included in the second round of vertebrate genomic duplication.
T2243	8918-8927	RB	denotes	Therefore
T2244	8967-8974	VB	denotes	support
T2245	8927-8929	,	denotes	,
T2246	8929-8933	DT	denotes	this
T2247	8934-8942	NN	denotes	analysis
T2248	8943-8945	IN	denotes	of
T2249	8946-8948	NNP	denotes	T.
T2250	8949-8957	NNP	denotes	rubripes
T2251	8958-8962	VBZ	denotes	does
T2252	8963-8966	RB	denotes	not
T2253	8975-8978	DT	denotes	the
T2254	8979-8989	NN	denotes	hypothesis
T2255	8990-8994	IN	denotes	that
T2256	9041-9049	VBN	denotes	included
T2257	8995-8998	DT	denotes	the
T2258	8999-9005	NN	denotes	region
T2259	9006-9017	VBG	denotes	surrounding
T2260	9018-9021	DT	denotes	the
T2261	9028-9036	NN	denotes	ancestor
T2262	9022-9027	NN	denotes	TACC3
T2263	9037-9040	VBD	denotes	was
T2264	9050-9052	IN	denotes	in
T2265	9053-9056	DT	denotes	the
T2266	9064-9069	NN	denotes	round
T2267	9057-9063	JJ	denotes	second
T2268	9070-9072	IN	denotes	of
T2269	9073-9083	NN	denotes	vertebrate
T2270	9092-9103	NN	denotes	duplication
T2271	9084-9091	JJ	denotes	genomic
T2272	9103-9104	.	denotes	.
T2273	9104-9312	sentence	denotes	Examination of higher vertebrates led to the identification of splice variants of TACC1 and TACC2 in Mus musculus, and the assembly of the previously unidentified orthologues of TACC1-3 from Rattus norvegus.
T2274	9105-9116	NN	denotes	Examination
T2275	9139-9142	VBD	denotes	led
T2276	9117-9119	IN	denotes	of
T2277	9120-9126	JJR	denotes	higher
T2278	9127-9138	NNS	denotes	vertebrates
T2279	9143-9145	IN	denotes	to
T2280	9146-9149	DT	denotes	the
T2281	9150-9164	NN	denotes	identification
T2282	9165-9167	IN	denotes	of
T2283	9168-9174	NN	denotes	splice
T2284	9175-9183	NNS	denotes	variants
T2285	9184-9186	IN	denotes	of
T2286	9187-9192	NN	denotes	TACC1
T2287	9193-9196	CC	denotes	and
T2288	9197-9202	NN	denotes	TACC2
T2289	9203-9205	IN	denotes	in
T2290	9206-9209	NNP	denotes	Mus
T2291	9210-9218	NNP	denotes	musculus
T2292	9218-9220	,	denotes	,
T2293	9220-9223	CC	denotes	and
T2294	9224-9227	DT	denotes	the
T2295	9228-9236	NN	denotes	assembly
T2296	9237-9239	IN	denotes	of
T2297	9240-9243	DT	denotes	the
T2298	9268-9279	NNS	denotes	orthologues
T2299	9244-9254	RB	denotes	previously
T2300	9255-9267	JJ	denotes	unidentified
T2301	9280-9282	IN	denotes	of
T2302	9283-9288	NN	denotes	TACC1
T2303	9288-9289	HYPH	denotes	-
T2304	9289-9290	CD	denotes	3
T2305	9291-9295	IN	denotes	from
T2306	9296-9302	NN	denotes	Rattus
T2307	9303-9311	NN	denotes	norvegus
T2308	9311-9312	.	denotes	.
T2309	9312-9378	sentence	denotes	In addition, the TACC1X sequence was found on mouse chromosome X.
T2310	9313-9315	IN	denotes	In
T2311	9350-9355	VBN	denotes	found
T2312	9316-9324	NN	denotes	addition
T2313	9324-9326	,	denotes	,
T2314	9326-9329	DT	denotes	the
T2315	9337-9345	NN	denotes	sequence
T2316	9330-9336	NN	denotes	TACC1X
T2317	9346-9349	VBD	denotes	was
T2318	9356-9358	IN	denotes	on
T2319	9359-9364	NN	denotes	mouse
T2320	9376-9377	NN	denotes	X
T2321	9365-9375	NN	denotes	chromosome
T2322	9377-9378	.	denotes	.
T2323	9378-9535	sentence	denotes	This gene is clearly related to the mouse TACC1, however, further examination revealed a mouse B1 repeat distributed over the length of the proposed intron.
T2324	9379-9383	DT	denotes	This
T2325	9384-9388	NN	denotes	gene
T2326	9400-9407	VBN	denotes	related
T2327	9389-9391	VBZ	denotes	is
T2328	9392-9399	RB	denotes	clearly
T2329	9457-9465	VBD	denotes	revealed
T2330	9408-9410	IN	denotes	to
T2331	9411-9414	DT	denotes	the
T2332	9421-9426	NN	denotes	TACC1
T2333	9415-9420	NN	denotes	mouse
T2334	9426-9428	,	denotes	,
T2335	9428-9435	RB	denotes	however
T2336	9435-9437	,	denotes	,
T2337	9437-9444	JJ	denotes	further
T2338	9445-9456	NN	denotes	examination
T2339	9466-9467	DT	denotes	a
T2340	9477-9483	NN	denotes	repeat
T2341	9468-9473	NN	denotes	mouse
T2342	9474-9476	NN	denotes	B1
T2343	9484-9495	VBN	denotes	distributed
T2344	9496-9500	IN	denotes	over
T2345	9501-9504	DT	denotes	the
T2346	9505-9511	NN	denotes	length
T2347	9512-9514	IN	denotes	of
T2348	9515-9518	DT	denotes	the
T2349	9528-9534	NN	denotes	intron
T2350	9519-9527	VBN	denotes	proposed
T2351	9534-9535	.	denotes	.
T2352	9535-9692	sentence	denotes	In addition, no expression of TACC1X was detected in mouse RNA by rt-PCR analysis (data not shown), suggesting that this sequence is a processed pseudogene.
T2353	9536-9538	IN	denotes	In
T2354	9577-9585	VBN	denotes	detected
T2355	9539-9547	NN	denotes	addition
T2356	9547-9549	,	denotes	,
T2357	9549-9551	DT	denotes	no
T2358	9552-9562	NN	denotes	expression
T2359	9563-9565	IN	denotes	of
T2360	9566-9572	NN	denotes	TACC1X
T2361	9573-9576	VBD	denotes	was
T2362	9586-9588	IN	denotes	in
T2363	9589-9594	NN	denotes	mouse
T2364	9595-9598	NN	denotes	RNA
T2365	9599-9601	IN	denotes	by
T2366	9602-9604	NN	denotes	rt
T2367	9605-9608	NN	denotes	PCR
T2368	9604-9605	HYPH	denotes	-
T2369	9609-9617	NN	denotes	analysis
T2370	9618-9619	-LRB-	denotes	(
T2371	9628-9633	VBN	denotes	shown
T2372	9619-9623	NNS	denotes	data
T2373	9624-9627	RB	denotes	not
T2374	9633-9634	-RRB-	denotes	)
T2375	9634-9636	,	denotes	,
T2376	9636-9646	VBG	denotes	suggesting
T2377	9647-9651	IN	denotes	that
T2378	9666-9668	VBZ	denotes	is
T2379	9652-9656	DT	denotes	this
T2380	9657-9665	NN	denotes	sequence
T2381	9669-9670	DT	denotes	a
T2382	9681-9691	NN	denotes	pseudogene
T2383	9671-9680	VBN	denotes	processed
T2384	9691-9692	.	denotes	.
T2385	9692-9901	sentence	denotes	Similarly, TACC1 pseudogenes also exist spread over 22 kb of the centromeric region of human chromosome 10 and, in 8q21, a shorter region 86% identical to the final 359 bp of the TACC1 3' untranslated region.
T2386	9693-9702	RB	denotes	Similarly
T2387	9727-9732	VBP	denotes	exist
T2388	9702-9704	,	denotes	,
T2389	9704-9709	NN	denotes	TACC1
T2390	9710-9721	NNS	denotes	pseudogenes
T2391	9722-9726	RB	denotes	also
T2392	9733-9739	VBN	denotes	spread
T2393	9740-9744	IN	denotes	over
T2394	9745-9747	CD	denotes	22
T2395	9748-9750	NN	denotes	kb
T2396	9751-9753	IN	denotes	of
T2397	9754-9757	DT	denotes	the
T2398	9770-9776	NN	denotes	region
T2399	9758-9769	JJ	denotes	centromeric
T2400	9777-9779	IN	denotes	of
T2401	9780-9785	JJ	denotes	human
T2402	9786-9796	NN	denotes	chromosome
T2403	9797-9799	CD	denotes	10
T2404	9800-9803	CC	denotes	and
T2405	9803-9805	,	denotes	,
T2406	9805-9807	IN	denotes	in
T2407	9808-9812	NN	denotes	8q21
T2408	9812-9814	,	denotes	,
T2409	9814-9815	DT	denotes	a
T2410	9824-9830	NN	denotes	region
T2411	9816-9823	JJR	denotes	shorter
T2412	9831-9833	CD	denotes	86
T2413	9833-9834	NN	denotes	%
T2414	9835-9844	JJ	denotes	identical
T2415	9845-9847	IN	denotes	to
T2416	9848-9851	DT	denotes	the
T2417	9862-9864	NN	denotes	bp
T2418	9852-9857	JJ	denotes	final
T2419	9858-9861	CD	denotes	359
T2420	9865-9867	IN	denotes	of
T2421	9868-9871	DT	denotes	the
T2422	9894-9900	NN	denotes	region
T2423	9872-9877	NN	denotes	TACC1
T2424	9878-9879	CD	denotes	3
T2425	9879-9880	SYM	denotes	'
T2426	9881-9893	JJ	denotes	untranslated
T2427	9900-9901	.	denotes	.
T2428	9901-9990	sentence	denotes	No pseudogenes corresponding to TACC2 or TACC3 were identified in any mammalian species.
T2429	9902-9904	DT	denotes	No
T2430	9905-9916	NNS	denotes	pseudogenes
T2431	9954-9964	VBN	denotes	identified
T2432	9917-9930	VBG	denotes	corresponding
T2433	9931-9933	IN	denotes	to
T2434	9934-9939	NN	denotes	TACC2
T2435	9940-9942	CC	denotes	or
T2436	9943-9948	NN	denotes	TACC3
T2437	9949-9953	VBD	denotes	were
T2438	9965-9967	IN	denotes	in
T2439	9968-9971	DT	denotes	any
T2440	9982-9989	NNS	denotes	species
T2441	9972-9981	JJ	denotes	mammalian
T2442	9989-9990	.	denotes	.
T13814	32819-32820	.	denotes	.
T2677	9992-10008	NN	denotes	Characterization
T2678	10009-10011	IN	denotes	of
T2679	10012-10022	NN	denotes	vertebrate
T2680	10023-10028	NN	denotes	TACC3
T2681	10029-10040	NNS	denotes	orthologues
T2682	10040-10226	sentence	denotes	Based upon current functional analysis, the characterization of TACC3 orthologues is likely to be pivotal to understanding the sequence and functional evolution of the TACC gene family.
T2683	10041-10046	VBN	denotes	Based
T2684	10123-10125	VBZ	denotes	is
T2685	10047-10051	IN	denotes	upon
T2686	10052-10059	JJ	denotes	current
T2687	10071-10079	NN	denotes	analysis
T2688	10060-10070	JJ	denotes	functional
T2689	10079-10081	,	denotes	,
T2690	10081-10084	DT	denotes	the
T2691	10085-10101	NN	denotes	characterization
T2692	10102-10104	IN	denotes	of
T2693	10105-10110	NN	denotes	TACC3
T2694	10111-10122	NNS	denotes	orthologues
T2695	10126-10132	JJ	denotes	likely
T2696	10133-10135	TO	denotes	to
T2697	10136-10138	VB	denotes	be
T2698	10139-10146	JJ	denotes	pivotal
T2699	10147-10149	IN	denotes	to
T2700	10150-10163	VBG	denotes	understanding
T2701	10164-10167	DT	denotes	the
T2702	10168-10176	NN	denotes	sequence
T2703	10177-10180	CC	denotes	and
T2704	10181-10191	JJ	denotes	functional
T2705	10192-10201	NN	denotes	evolution
T2706	10202-10204	IN	denotes	of
T2707	10205-10208	DT	denotes	the
T2708	10219-10225	NN	denotes	family
T2709	10209-10213	NN	denotes	TACC
T2710	10214-10218	NN	denotes	gene
T2711	10225-10226	.	denotes	.
T2712	10226-10355	sentence	denotes	As indicated below, the chromosomal region containing the TACC gene precursors was duplicated twice during vertebrate evolution.
T2713	10227-10229	IN	denotes	As
T2714	10230-10239	VBN	denotes	indicated
T2715	10310-10320	VBN	denotes	duplicated
T2716	10240-10245	RB	denotes	below
T2717	10245-10247	,	denotes	,
T2718	10247-10250	DT	denotes	the
T2719	10263-10269	NN	denotes	region
T2720	10251-10262	JJ	denotes	chromosomal
T2721	10270-10280	VBG	denotes	containing
T2722	10281-10284	DT	denotes	the
T2723	10295-10305	NNS	denotes	precursors
T2724	10285-10289	NN	denotes	TACC
T2725	10290-10294	NN	denotes	gene
T2726	10306-10309	VBD	denotes	was
T2727	10321-10326	RB	denotes	twice
T2728	10327-10333	IN	denotes	during
T2729	10334-10344	NN	denotes	vertebrate
T2730	10345-10354	NN	denotes	evolution
T2731	10354-10355	.	denotes	.
T2732	10355-10627	sentence	denotes	Although the analysis of T. rubripes, rodents and humans so far suggests that the vertebrate TACC3 precursor was not included in the second round of genomic duplication, it could not be excluded that a TACC4 gene may have been lost during the evolution of these lineages.
T2733	10356-10364	IN	denotes	Although
T2734	10420-10428	VBZ	denotes	suggests
T2735	10365-10368	DT	denotes	the
T2736	10369-10377	NN	denotes	analysis
T2737	10378-10380	IN	denotes	of
T2738	10381-10383	NNP	denotes	T.
T2739	10384-10392	NNP	denotes	rubripes
T2740	10392-10394	,	denotes	,
T2741	10394-10401	NNS	denotes	rodents
T2742	10402-10405	CC	denotes	and
T2743	10406-10412	NNS	denotes	humans
T2744	10413-10415	RB	denotes	so
T2745	10416-10419	RB	denotes	far
T2746	10542-10550	VBN	denotes	excluded
T2747	10429-10433	IN	denotes	that
T2748	10473-10481	VBN	denotes	included
T2749	10434-10437	DT	denotes	the
T2750	10455-10464	NN	denotes	precursor
T2751	10438-10448	NN	denotes	vertebrate
T2752	10449-10454	NN	denotes	TACC3
T2753	10465-10468	VBD	denotes	was
T2754	10469-10472	RB	denotes	not
T2755	10482-10484	IN	denotes	in
T2756	10485-10488	DT	denotes	the
T2757	10496-10501	NN	denotes	round
T2758	10489-10495	JJ	denotes	second
T2759	10502-10504	IN	denotes	of
T2760	10505-10512	JJ	denotes	genomic
T2761	10513-10524	NN	denotes	duplication
T2762	10524-10526	,	denotes	,
T2763	10526-10528	PRP	denotes	it
T2764	10529-10534	MD	denotes	could
T2765	10535-10538	RB	denotes	not
T2766	10539-10541	VB	denotes	be
T2767	10551-10555	IN	denotes	that
T2768	10583-10587	VBN	denotes	lost
T2769	10556-10557	DT	denotes	a
T2770	10564-10568	NN	denotes	gene
T2771	10558-10563	NN	denotes	TACC4
T2772	10569-10572	MD	denotes	may
T2773	10573-10577	VB	denotes	have
T2774	10578-10582	VBN	denotes	been
T2775	10588-10594	IN	denotes	during
T2776	10595-10598	DT	denotes	the
T2777	10599-10608	NN	denotes	evolution
T2778	10609-10611	IN	denotes	of
T2779	10612-10617	DT	denotes	these
T2780	10618-10626	NNS	denotes	lineages
T2781	10626-10627	.	denotes	.
T2782	10627-10734	sentence	denotes	The cloning of a new member of the TACC family in Oryctolagus cuniculus has added to this controversy [9].
T2783	10628-10631	DT	denotes	The
T2784	10632-10639	NN	denotes	cloning
T2785	10704-10709	VBN	denotes	added
T2786	10640-10642	IN	denotes	of
T2787	10643-10644	DT	denotes	a
T2788	10649-10655	NN	denotes	member
T2789	10645-10648	JJ	denotes	new
T2790	10656-10658	IN	denotes	of
T2791	10659-10662	DT	denotes	the
T2792	10668-10674	NN	denotes	family
T2793	10663-10667	NN	denotes	TACC
T2794	10675-10677	IN	denotes	in
T2795	10678-10689	NNP	denotes	Oryctolagus
T2796	10690-10699	NNP	denotes	cuniculus
T2797	10700-10703	VBZ	denotes	has
T2798	10710-10712	IN	denotes	to
T2799	10713-10717	DT	denotes	this
T2800	10718-10729	NN	denotes	controversy
T2801	10730-10731	-LRB-	denotes	[
T2802	10731-10732	CD	denotes	9
T2803	10732-10733	-RRB-	denotes	]
T2804	10733-10734	.	denotes	.
T2805	10734-10828	sentence	denotes	Designated TACC4, the 1.5 kb cDNA was highly related, but proposed to be distinct from TACC3.
T2806	10735-10745	VBN	denotes	Designated
T2807	10769-10772	VBD	denotes	was
T2808	10746-10751	NN	denotes	TACC4
T2809	10751-10753	,	denotes	,
T2810	10753-10756	DT	denotes	the
T2811	10764-10768	NN	denotes	cDNA
T2812	10757-10760	CD	denotes	1.5
T2813	10761-10763	NN	denotes	kb
T2814	10773-10779	RB	denotes	highly
T2815	10780-10787	VBN	denotes	related
T2816	10787-10789	,	denotes	,
T2817	10789-10792	CC	denotes	but
T2818	10793-10801	VBN	denotes	proposed
T2819	10802-10804	TO	denotes	to
T2820	10805-10807	VB	denotes	be
T2821	10808-10816	JJ	denotes	distinct
T2822	10817-10821	IN	denotes	from
T2823	10822-10827	NN	denotes	TACC3
T2824	10827-10828	.	denotes	.
T2825	10828-10970	sentence	denotes	However, Northern blot data suggested that this gene produces a single 2.3 kb transcript [9], indicating that the cloned cDNA was incomplete.
T2826	10829-10836	RB	denotes	However
T2827	10857-10866	VBD	denotes	suggested
T2828	10836-10838	,	denotes	,
T2829	10838-10846	NNP	denotes	Northern
T2830	10847-10851	NN	denotes	blot
T2831	10852-10856	NNS	denotes	data
T2832	10867-10871	IN	denotes	that
T2833	10882-10890	VBZ	denotes	produces
T2834	10872-10876	DT	denotes	this
T2835	10877-10881	NN	denotes	gene
T2836	10891-10892	DT	denotes	a
T2837	10907-10917	NN	denotes	transcript
T2838	10893-10899	JJ	denotes	single
T2839	10900-10903	CD	denotes	2.3
T2840	10904-10906	NN	denotes	kb
T2841	10918-10919	-LRB-	denotes	[
T2842	10919-10920	CD	denotes	9
T2843	10920-10921	-RRB-	denotes	]
T2844	10921-10923	,	denotes	,
T2845	10923-10933	VBG	denotes	indicating
T2846	10934-10938	IN	denotes	that
T2847	10955-10958	VBD	denotes	was
T2848	10939-10942	DT	denotes	the
T2849	10950-10954	NN	denotes	cDNA
T2850	10943-10949	VBN	denotes	cloned
T2851	10959-10969	JJ	denotes	incomplete
T2852	10969-10970	.	denotes	.
T2853	10970-11122	sentence	denotes	The degree of similarity to the published sequence of human and mouse TACC3 suggested to us that TACC4 actually represents a partial rabbit TACC3 cDNA.
T2854	10971-10974	DT	denotes	The
T2855	10975-10981	NN	denotes	degree
T2856	11047-11056	VBD	denotes	suggested
T2857	10982-10984	IN	denotes	of
T2858	10985-10995	NN	denotes	similarity
T2859	10996-10998	IN	denotes	to
T2860	10999-11002	DT	denotes	the
T2861	11013-11021	NN	denotes	sequence
T2862	11003-11012	VBN	denotes	published
T2863	11022-11024	IN	denotes	of
T2864	11025-11030	JJ	denotes	human
T2865	11041-11046	NN	denotes	TACC3
T2866	11031-11034	CC	denotes	and
T2867	11035-11040	NN	denotes	mouse
T2868	11057-11059	IN	denotes	to
T2869	11060-11062	PRP	denotes	us
T2870	11063-11067	IN	denotes	that
T2871	11083-11093	VBZ	denotes	represents
T2872	11068-11073	NN	denotes	TACC4
T2873	11074-11082	RB	denotes	actually
T2874	11094-11095	DT	denotes	a
T2875	11117-11121	NN	denotes	cDNA
T2876	11096-11103	JJ	denotes	partial
T2877	11104-11110	NN	denotes	rabbit
T2878	11111-11116	NN	denotes	TACC3
T2879	11121-11122	.	denotes	.
T2880	11122-11259	sentence	denotes	To test this hypothesis, we set out to clone the complete rabbit TACC3 sequence, based upon the known features of human and mouse TACC3.
T2881	11123-11125	TO	denotes	To
T2882	11126-11130	VB	denotes	test
T2883	11151-11154	VBD	denotes	set
T2884	11131-11135	DT	denotes	this
T2885	11136-11146	NN	denotes	hypothesis
T2886	11146-11148	,	denotes	,
T2887	11148-11150	PRP	denotes	we
T2888	11155-11158	RP	denotes	out
T2889	11159-11161	TO	denotes	to
T2890	11162-11167	VB	denotes	clone
T2891	11168-11171	DT	denotes	the
T2892	11194-11202	NN	denotes	sequence
T2893	11172-11180	JJ	denotes	complete
T2894	11181-11187	NN	denotes	rabbit
T2895	11188-11193	NN	denotes	TACC3
T2896	11202-11204	,	denotes	,
T2897	11204-11209	VBN	denotes	based
T2898	11210-11214	IN	denotes	upon
T2899	11215-11218	DT	denotes	the
T2900	11225-11233	NNS	denotes	features
T2901	11219-11224	JJ	denotes	known
T2902	11234-11236	IN	denotes	of
T2903	11237-11242	JJ	denotes	human
T2904	11253-11258	NN	denotes	TACC3
T2905	11243-11246	CC	denotes	and
T2906	11247-11252	NN	denotes	mouse
T2907	11258-11259	.	denotes	.
T2908	11259-11404	sentence	denotes	We have previously noted that the N-terminal and C-terminal regions of the human and mouse TACC3 proteins are highly conserved ([2], see below).
T2909	11260-11262	PRP	denotes	We
T2910	11279-11284	VBN	denotes	noted
T2911	11263-11267	VBP	denotes	have
T2912	11268-11278	RB	denotes	previously
T2913	11285-11289	IN	denotes	that
T2914	11366-11369	VBP	denotes	are
T2915	11290-11293	DT	denotes	the
T2916	11320-11327	NNS	denotes	regions
T2917	11294-11295	NN	denotes	N
T2918	11296-11304	JJ	denotes	terminal
T2919	11295-11296	HYPH	denotes	-
T2920	11305-11308	CC	denotes	and
T2921	11309-11310	NN	denotes	C
T2922	11311-11319	JJ	denotes	terminal
T2923	11310-11311	HYPH	denotes	-
T2924	11328-11330	IN	denotes	of
T2925	11331-11334	DT	denotes	the
T2926	11357-11365	NN	denotes	proteins
T2927	11335-11340	JJ	denotes	human
T2928	11341-11344	CC	denotes	and
T2929	11345-11350	NN	denotes	mouse
T2930	11351-11356	NN	denotes	TACC3
T2931	11370-11376	RB	denotes	highly
T2932	11377-11386	VBN	denotes	conserved
T2933	11387-11388	-LRB-	denotes	(
T2934	11389-11390	CD	denotes	2
T2935	11388-11389	-LRB-	denotes	[
T2936	11390-11391	-RRB-	denotes	]
T2937	11391-11393	,	denotes	,
T2938	11393-11396	VBP	denotes	see
T2939	11397-11402	RB	denotes	below
T2940	11402-11403	-RRB-	denotes	)
T2941	11403-11404	.	denotes	.
T2942	11404-11667	sentence	denotes	Therefore, based upon the sequence identity between these genes, we designed a consensus oligonucleotide primer, T3con2, that would be suitable for the identification of the region containing the initiator methionine of the TACC3 cDNAs from primates and rodents.
T2943	11405-11414	RB	denotes	Therefore
T2944	11473-11481	VBD	denotes	designed
T2945	11414-11416	,	denotes	,
T2946	11416-11421	VBN	denotes	based
T2947	11422-11426	IN	denotes	upon
T2948	11427-11430	DT	denotes	the
T2949	11440-11448	NN	denotes	identity
T2950	11431-11439	NN	denotes	sequence
T2951	11449-11456	IN	denotes	between
T2952	11457-11462	DT	denotes	these
T2953	11463-11468	NNS	denotes	genes
T2954	11468-11470	,	denotes	,
T2955	11470-11472	PRP	denotes	we
T2956	11482-11483	DT	denotes	a
T2957	11510-11516	NN	denotes	primer
T2958	11484-11493	NN	denotes	consensus
T2959	11494-11509	NN	denotes	oligonucleotide
T2960	11516-11518	,	denotes	,
T2961	11518-11524	NN	denotes	T3con2
T2962	11524-11526	,	denotes	,
T2963	11526-11530	WDT	denotes	that
T2964	11537-11539	VB	denotes	be
T2965	11531-11536	MD	denotes	would
T2966	11540-11548	JJ	denotes	suitable
T2967	11549-11552	IN	denotes	for
T2968	11553-11556	DT	denotes	the
T2969	11557-11571	NN	denotes	identification
T2970	11572-11574	IN	denotes	of
T2971	11575-11578	DT	denotes	the
T2972	11579-11585	NN	denotes	region
T2973	11586-11596	VBG	denotes	containing
T2974	11597-11600	DT	denotes	the
T2975	11611-11621	NN	denotes	methionine
T2976	11601-11610	NN	denotes	initiator
T2977	11622-11624	IN	denotes	of
T2978	11625-11628	DT	denotes	the
T2979	11635-11640	NNS	denotes	cDNAs
T2980	11629-11634	NN	denotes	TACC3
T2981	11641-11645	IN	denotes	from
T2982	11646-11654	NNS	denotes	primates
T2983	11655-11658	CC	denotes	and
T2984	11659-11666	NNS	denotes	rodents
T2985	11666-11667	.	denotes	.
T2986	11667-11851	sentence	denotes	Using this primer, in combination with the TACC4-specific RACE primer (RACE2), initially used by Steadman et al [9], we isolated a 1.5 kb PCR product from rabbit brain cDNA by rt-PCR.
T2987	11668-11673	VBG	denotes	Using
T2988	11788-11796	VBN	denotes	isolated
T2989	11674-11678	DT	denotes	this
T2990	11679-11685	NN	denotes	primer
T2991	11685-11687	,	denotes	,
T2992	11687-11689	IN	denotes	in
T2993	11690-11701	NN	denotes	combination
T2994	11702-11706	IN	denotes	with
T2995	11707-11710	DT	denotes	the
T2996	11731-11737	NN	denotes	primer
T2997	11711-11716	NN	denotes	TACC4
T2998	11717-11725	JJ	denotes	specific
T2999	11716-11717	HYPH	denotes	-
T3000	11726-11730	NN	denotes	RACE
T3001	11738-11739	-LRB-	denotes	(
T3002	11739-11744	NN	denotes	RACE2
T3003	11744-11745	-RRB-	denotes	)
T3004	11745-11747	,	denotes	,
T3005	11747-11756	RB	denotes	initially
T3006	11757-11761	VBN	denotes	used
T3007	11762-11764	IN	denotes	by
T3008	11765-11773	NNP	denotes	Steadman
T3009	11774-11776	FW	denotes	et
T3010	11777-11779	FW	denotes	al
T3011	11780-11781	-LRB-	denotes	[
T3012	11781-11782	CD	denotes	9
T3013	11782-11783	-RRB-	denotes	]
T3014	11783-11785	,	denotes	,
T3015	11785-11787	PRP	denotes	we
T3016	11797-11798	DT	denotes	a
T3017	11810-11817	NN	denotes	product
T3018	11799-11802	CD	denotes	1.5
T3019	11803-11805	NN	denotes	kb
T3020	11806-11809	NN	denotes	PCR
T3021	11818-11822	IN	denotes	from
T3022	11823-11829	NN	denotes	rabbit
T3023	11836-11840	NN	denotes	cDNA
T3024	11830-11835	NN	denotes	brain
T3025	11841-11843	IN	denotes	by
T3026	11844-11846	NN	denotes	rt
T3027	11847-11850	NN	denotes	PCR
T3028	11846-11847	HYPH	denotes	-
T3029	11850-11851	.	denotes	.
T3030	11851-12050	sentence	denotes	In combination with 3'RACE, this generated a consensus cDNA of 2283 bp which corresponds to the transcript size of 2.3 kb detected by the "TACC4" sequence reported in Figure 4 of Steadman et al [9].
T3031	11852-11854	IN	denotes	In
T3032	11885-11894	VBD	denotes	generated
T3033	11855-11866	NN	denotes	combination
T3034	11867-11871	IN	denotes	with
T3035	11872-11873	CD	denotes	3
T3036	11874-11878	NN	denotes	RACE
T3037	11873-11874	SYM	denotes	'
T3038	11878-11880	,	denotes	,
T3039	11880-11884	DT	denotes	this
T3040	11895-11896	DT	denotes	a
T3041	11907-11911	NN	denotes	cDNA
T3042	11897-11906	NN	denotes	consensus
T3043	11912-11914	IN	denotes	of
T3044	11915-11919	CD	denotes	2283
T3045	11920-11922	NN	denotes	bp
T3046	11923-11928	WDT	denotes	which
T3047	11929-11940	VBZ	denotes	corresponds
T3048	11941-11943	IN	denotes	to
T3049	11944-11947	DT	denotes	the
T3050	11959-11963	NN	denotes	size
T3051	11948-11958	NN	denotes	transcript
T3052	11964-11966	IN	denotes	of
T3053	11967-11970	CD	denotes	2.3
T3054	11971-11973	NN	denotes	kb
T3055	11974-11982	VBN	denotes	detected
T3056	11983-11985	IN	denotes	by
T3057	11986-11989	DT	denotes	the
T3058	11998-12006	NN	denotes	sequence
T3059	11990-11991	``	denotes	"
T3060	11991-11996	NN	denotes	TACC4
T3061	11996-11997	''	denotes	"
T3062	12007-12015	VBN	denotes	reported
T3063	12016-12018	IN	denotes	in
T3064	12019-12025	NN	denotes	Figure
T3065	12026-12027	CD	denotes	4
T3066	12028-12030	IN	denotes	of
T3067	12031-12039	NNP	denotes	Steadman
T3068	12040-12042	FW	denotes	et
T3069	12043-12045	FW	denotes	al
T3070	12046-12047	-LRB-	denotes	[
T3071	12047-12048	CD	denotes	9
T3072	12048-12049	-RRB-	denotes	]
T3073	12049-12050	.	denotes	.
T3074	12050-12382	sentence	denotes	Thus, while it remains possible that the "TACC4" sequence is an alternative splice product, or is the product of reduplication of the TACC3 gene (events that would be specific to the rabbit), the only transcript detected in rabbit RNA corresponds to the predicted transcript size of the TACC3 sequence that we have identified here.
T3075	12051-12055	RB	denotes	Thus
T3076	12286-12297	VBZ	denotes	corresponds
T3077	12055-12057	,	denotes	,
T3078	12057-12062	IN	denotes	while
T3079	12066-12073	VBZ	denotes	remains
T3080	12063-12065	PRP	denotes	it
T3081	12074-12082	JJ	denotes	possible
T3082	12083-12087	IN	denotes	that
T3083	12109-12111	VBZ	denotes	is
T3084	12088-12091	DT	denotes	the
T3085	12100-12108	NN	denotes	sequence
T3086	12092-12093	``	denotes	"
T3087	12093-12098	NN	denotes	TACC4
T3088	12098-12099	''	denotes	"
T3089	12112-12114	DT	denotes	an
T3090	12134-12141	NN	denotes	product
T3091	12115-12126	JJ	denotes	alternative
T3092	12127-12133	NN	denotes	splice
T3093	12141-12143	,	denotes	,
T3094	12143-12145	CC	denotes	or
T3095	12146-12148	VBZ	denotes	is
T3096	12149-12152	DT	denotes	the
T3097	12153-12160	NN	denotes	product
T3098	12161-12163	IN	denotes	of
T3099	12164-12177	NN	denotes	reduplication
T3100	12178-12180	IN	denotes	of
T3101	12181-12184	DT	denotes	the
T3102	12191-12195	NN	denotes	gene
T3103	12185-12190	NN	denotes	TACC3
T3104	12196-12197	-LRB-	denotes	(
T3105	12197-12203	NNS	denotes	events
T3106	12204-12208	WDT	denotes	that
T3107	12215-12217	VB	denotes	be
T3108	12209-12214	MD	denotes	would
T3109	12218-12226	JJ	denotes	specific
T3110	12227-12229	IN	denotes	to
T3111	12230-12233	DT	denotes	the
T3112	12234-12240	NN	denotes	rabbit
T3113	12240-12241	-RRB-	denotes	)
T3114	12241-12243	,	denotes	,
T3115	12243-12246	DT	denotes	the
T3116	12252-12262	NN	denotes	transcript
T3117	12247-12251	JJ	denotes	only
T3118	12263-12271	VBN	denotes	detected
T3119	12272-12274	IN	denotes	in
T3120	12275-12281	NN	denotes	rabbit
T3121	12282-12285	NN	denotes	RNA
T3122	12298-12300	IN	denotes	to
T3123	12301-12304	DT	denotes	the
T3124	12326-12330	NN	denotes	size
T3125	12305-12314	VBN	denotes	predicted
T3126	12315-12325	NN	denotes	transcript
T3127	12331-12333	IN	denotes	of
T3128	12334-12337	DT	denotes	the
T3129	12344-12352	NN	denotes	sequence
T3130	12338-12343	NN	denotes	TACC3
T3131	12353-12357	WDT	denotes	that
T3132	12366-12376	VBN	denotes	identified
T3133	12358-12360	PRP	denotes	we
T3134	12361-12365	VBP	denotes	have
T3135	12377-12381	RB	denotes	here
T3136	12381-12382	.	denotes	.
T3137	12382-12685	sentence	denotes	Furthermore, the string of nucleotides found at the 5' end of the "TACC4" sequence is also found at the 5' ends of a number of cDNA sequences (e.g. U82468, NM_023500), that were isolated by 5'RACE, suggesting that they may correspond to an artefact of the 5'RACE methodology used in their construction.
T3138	12383-12394	RB	denotes	Furthermore
T3139	12474-12479	VBN	denotes	found
T3140	12394-12396	,	denotes	,
T3141	12396-12399	DT	denotes	the
T3142	12400-12406	NN	denotes	string
T3143	12407-12409	IN	denotes	of
T3144	12410-12421	NNS	denotes	nucleotides
T3145	12422-12427	VBN	denotes	found
T3146	12428-12430	IN	denotes	at
T3147	12431-12434	DT	denotes	the
T3148	12438-12441	NN	denotes	end
T3149	12435-12436	CD	denotes	5
T3150	12436-12437	SYM	denotes	'
T3151	12442-12444	IN	denotes	of
T3152	12445-12448	DT	denotes	the
T3153	12457-12465	NN	denotes	sequence
T3154	12449-12450	``	denotes	"
T3155	12450-12455	NN	denotes	TACC4
T3156	12455-12456	''	denotes	"
T3157	12466-12468	VBZ	denotes	is
T3158	12469-12473	RB	denotes	also
T3159	12480-12482	IN	denotes	at
T3160	12483-12486	DT	denotes	the
T3161	12490-12494	NNS	denotes	ends
T3162	12487-12488	CD	denotes	5
T3163	12488-12489	SYM	denotes	'
T3164	12495-12497	IN	denotes	of
T3165	12498-12499	DT	denotes	a
T3166	12500-12506	NN	denotes	number
T3167	12507-12509	IN	denotes	of
T3168	12510-12514	NN	denotes	cDNA
T3169	12515-12524	NNS	denotes	sequences
T3170	12525-12526	-LRB-	denotes	(
T3171	12526-12530	FW	denotes	e.g.
T3172	12539-12548	NN	denotes	NM_023500
T3173	12531-12537	NN	denotes	U82468
T3174	12537-12539	,	denotes	,
T3175	12548-12549	-RRB-	denotes	)
T3176	12549-12551	,	denotes	,
T3177	12551-12555	WDT	denotes	that
T3178	12561-12569	VBN	denotes	isolated
T3179	12556-12560	VBD	denotes	were
T3180	12570-12572	IN	denotes	by
T3181	12573-12574	CD	denotes	5
T3182	12575-12579	NN	denotes	RACE
T3183	12574-12575	SYM	denotes	'
T3184	12579-12581	,	denotes	,
T3185	12581-12591	VBG	denotes	suggesting
T3186	12592-12596	IN	denotes	that
T3187	12606-12616	VB	denotes	correspond
T3188	12597-12601	PRP	denotes	they
T3189	12602-12605	MD	denotes	may
T3190	12617-12619	IN	denotes	to
T3191	12620-12622	DT	denotes	an
T3192	12623-12631	NN	denotes	artefact
T3193	12632-12634	IN	denotes	of
T3194	12635-12638	DT	denotes	the
T3195	12646-12657	NN	denotes	methodology
T3196	12639-12640	CD	denotes	5
T3197	12640-12641	SYM	denotes	'
T3198	12641-12645	NN	denotes	RACE
T3199	12658-12662	VBN	denotes	used
T3200	12663-12665	IN	denotes	in
T3201	12666-12671	PRP$	denotes	their
T3202	12672-12684	NN	denotes	construction
T3203	12684-12685	.	denotes	.
T3204	12685-13053	sentence	denotes	The rabbit "TACC4" and the rabbit TACC3 sequence that we have isolated are also found on the same branch of the TACC phylogenetic tree with the other TACC3 orthologues, including maskin (Xenopus laevis), and the newly identified TACC3 sequences in Rattus norvegus, Gallus gallus, Silurana tropicalis, Danio rerio and T. rubripes, reported in this manuscript (Fig. 1).
T3205	12686-12689	DT	denotes	The
T3206	12698-12703	NN	denotes	TACC4
T3207	12690-12696	NN	denotes	rabbit
T3208	12697-12698	``	denotes	"
T3209	12766-12771	VBN	denotes	found
T3210	12703-12704	''	denotes	"
T3211	12705-12708	CC	denotes	and
T3212	12709-12712	DT	denotes	the
T3213	12720-12725	NN	denotes	TACC3
T3214	12713-12719	NN	denotes	rabbit
T3215	12726-12734	NN	denotes	sequence
T3216	12735-12739	WDT	denotes	that
T3217	12748-12756	VBN	denotes	isolated
T3218	12740-12742	PRP	denotes	we
T3219	12743-12747	VBP	denotes	have
T3220	12757-12760	VBP	denotes	are
T3221	12761-12765	RB	denotes	also
T3222	12772-12774	IN	denotes	on
T3223	12775-12778	DT	denotes	the
T3224	12784-12790	NN	denotes	branch
T3225	12779-12783	JJ	denotes	same
T3226	12791-12793	IN	denotes	of
T3227	12794-12797	DT	denotes	the
T3228	12816-12820	NN	denotes	tree
T3229	12798-12802	NN	denotes	TACC
T3230	12803-12815	JJ	denotes	phylogenetic
T3231	12821-12825	IN	denotes	with
T3232	12826-12829	DT	denotes	the
T3233	12842-12853	NNS	denotes	orthologues
T3234	12830-12835	JJ	denotes	other
T3235	12836-12841	NN	denotes	TACC3
T3236	12853-12855	,	denotes	,
T3237	12855-12864	VBG	denotes	including
T3238	12865-12871	NN	denotes	maskin
T3239	12872-12873	-LRB-	denotes	(
T3240	12873-12880	NNP	denotes	Xenopus
T3241	12881-12887	NNP	denotes	laevis
T3242	12887-12888	-RRB-	denotes	)
T3243	12888-12890	,	denotes	,
T3244	12890-12893	CC	denotes	and
T3245	12894-12897	DT	denotes	the
T3246	12921-12930	NNS	denotes	sequences
T3247	12898-12903	RB	denotes	newly
T3248	12904-12914	VBN	denotes	identified
T3249	12915-12920	NN	denotes	TACC3
T3250	12931-12933	IN	denotes	in
T3251	12934-12940	NNP	denotes	Rattus
T3252	12941-12949	NNP	denotes	norvegus
T3253	12949-12951	,	denotes	,
T3254	12951-12957	NNP	denotes	Gallus
T3255	12958-12964	NN	denotes	gallus
T3256	12964-12966	,	denotes	,
T3257	12966-12974	NNP	denotes	Silurana
T3258	12975-12985	NNP	denotes	tropicalis
T3259	12985-12987	,	denotes	,
T3260	12987-12992	NNP	denotes	Danio
T3261	12993-12998	NNP	denotes	rerio
T3262	12999-13002	CC	denotes	and
T3263	13003-13005	NNP	denotes	T.
T3264	13006-13014	NNP	denotes	rubripes
T3265	13014-13016	,	denotes	,
T3266	13016-13024	VBN	denotes	reported
T3267	13025-13027	IN	denotes	in
T3268	13028-13032	DT	denotes	this
T3269	13033-13043	NN	denotes	manuscript
T3270	13044-13045	-LRB-	denotes	(
T3271	13045-13049	NN	denotes	Fig.
T3272	13050-13051	CD	denotes	1
T3273	13051-13052	-RRB-	denotes	)
T3274	13052-13053	.	denotes	.
T3275	13053-13162	sentence	denotes	Thus, it is not in a separate branch that may be expected if the sequence was a distinct TACC family member.
T3276	13054-13058	RB	denotes	Thus
T3277	13063-13065	VBZ	denotes	is
T3278	13058-13060	,	denotes	,
T3279	13060-13062	PRP	denotes	it
T3280	13066-13069	RB	denotes	not
T3281	13070-13072	IN	denotes	in
T3282	13073-13074	DT	denotes	a
T3283	13084-13090	NN	denotes	branch
T3284	13075-13083	JJ	denotes	separate
T3285	13091-13095	WDT	denotes	that
T3286	13103-13111	VBN	denotes	expected
T3287	13096-13099	MD	denotes	may
T3288	13100-13102	VB	denotes	be
T3289	13112-13114	IN	denotes	if
T3290	13128-13131	VBD	denotes	was
T3291	13115-13118	DT	denotes	the
T3292	13119-13127	NN	denotes	sequence
T3293	13132-13133	DT	denotes	a
T3294	13155-13161	NN	denotes	member
T3295	13134-13142	JJ	denotes	distinct
T3296	13143-13147	NN	denotes	TACC
T3297	13148-13154	NN	denotes	family
T3298	13161-13162	.	denotes	.
T3412	13164-13173	NN	denotes	Placement
T3413	13174-13176	IN	denotes	of
T3414	13177-13180	DT	denotes	the
T3415	13187-13191	NN	denotes	gene
T3416	13181-13186	NN	denotes	RHAMM
T3417	13192-13194	IN	denotes	in
T3418	13195-13198	DT	denotes	the
T3419	13199-13208	NN	denotes	phylogeny
T3420	13209-13211	IN	denotes	of
T3421	13212-13215	DT	denotes	the
T3422	13233-13239	NN	denotes	family
T3423	13216-13222	VBN	denotes	coiled
T3424	13223-13227	NN	denotes	coil
T3425	13228-13232	NN	denotes	gene
T3426	13239-13331	sentence	denotes	Human RHAMM has also been proposed to be the missing fourth member of the TACC family [10].
T3427	13240-13245	JJ	denotes	Human
T3428	13246-13251	NN	denotes	RHAMM
T3429	13266-13274	VBN	denotes	proposed
T3430	13252-13255	VBZ	denotes	has
T3431	13256-13260	RB	denotes	also
T3432	13261-13265	VBN	denotes	been
T3433	13275-13277	TO	denotes	to
T3434	13278-13280	VB	denotes	be
T3435	13281-13284	DT	denotes	the
T3436	13300-13306	NN	denotes	member
T3437	13285-13292	VBG	denotes	missing
T3438	13293-13299	JJ	denotes	fourth
T3439	13307-13309	IN	denotes	of
T3440	13310-13313	DT	denotes	the
T3441	13319-13325	NN	denotes	family
T3442	13314-13318	NN	denotes	TACC
T3443	13326-13327	-LRB-	denotes	[
T3444	13327-13329	CD	denotes	10
T3445	13329-13330	-RRB-	denotes	]
T3446	13330-13331	.	denotes	.
T3447	13331-13583	sentence	denotes	Evidence used in support of this claim included its chromosomal location on 5q32 in humans (discussed below), its sequence similarity in its coiled coil domain to the TACC domain and the subcellular localization of the RHAMM protein in the centrosome.
T3448	13332-13340	NN	denotes	Evidence
T3449	13371-13379	VBD	denotes	included
T3450	13341-13345	VBN	denotes	used
T3451	13346-13348	IN	denotes	in
T3452	13349-13356	NN	denotes	support
T3453	13357-13359	IN	denotes	of
T3454	13360-13364	DT	denotes	this
T3455	13365-13370	NN	denotes	claim
T3456	13380-13383	PRP$	denotes	its
T3457	13396-13404	NN	denotes	location
T3458	13384-13395	JJ	denotes	chromosomal
T3459	13405-13407	IN	denotes	on
T3460	13408-13412	NN	denotes	5q32
T3461	13413-13415	IN	denotes	in
T3462	13416-13422	NNS	denotes	humans
T3463	13423-13424	-LRB-	denotes	(
T3464	13424-13433	VBN	denotes	discussed
T3465	13434-13439	RB	denotes	below
T3466	13439-13440	-RRB-	denotes	)
T3467	13440-13442	,	denotes	,
T3468	13442-13445	PRP$	denotes	its
T3469	13455-13465	NN	denotes	similarity
T3470	13446-13454	NN	denotes	sequence
T3471	13466-13468	IN	denotes	in
T3472	13469-13472	PRP$	denotes	its
T3473	13485-13491	NN	denotes	domain
T3474	13473-13479	VBN	denotes	coiled
T3475	13480-13484	NN	denotes	coil
T3476	13492-13494	IN	denotes	to
T3477	13495-13498	DT	denotes	the
T3478	13504-13510	NN	denotes	domain
T3479	13499-13503	NN	denotes	TACC
T3480	13511-13514	CC	denotes	and
T3481	13515-13518	DT	denotes	the
T3482	13531-13543	NN	denotes	localization
T3483	13519-13530	JJ	denotes	subcellular
T3484	13544-13546	IN	denotes	of
T3485	13547-13550	DT	denotes	the
T3486	13557-13564	NN	denotes	protein
T3487	13551-13556	NN	denotes	RHAMM
T3488	13565-13567	IN	denotes	in
T3489	13568-13571	DT	denotes	the
T3490	13572-13582	NN	denotes	centrosome
T3491	13582-13583	.	denotes	.
T3492	13583-13792	sentence	denotes	However, if RHAMM were a bona fide TACC family member, then we would predict its evolution would be similar to those of other TACC family members, and fit with the proposed evolution of the vertebrate genome.
T3493	13584-13591	RB	denotes	However
T3494	13653-13660	VB	denotes	predict
T3495	13591-13593	,	denotes	,
T3496	13593-13595	IN	denotes	if
T3497	13602-13606	VB	denotes	were
T3498	13596-13601	NN	denotes	RHAMM
T3499	13607-13608	DT	denotes	a
T3500	13631-13637	NN	denotes	member
T3501	13609-13613	FW	denotes	bona
T3502	13614-13618	FW	denotes	fide
T3503	13619-13623	NN	denotes	TACC
T3504	13624-13630	NN	denotes	family
T3505	13637-13639	,	denotes	,
T3506	13639-13643	RB	denotes	then
T3507	13644-13646	PRP	denotes	we
T3508	13647-13652	MD	denotes	would
T3509	13661-13664	PRP$	denotes	its
T3510	13665-13674	NN	denotes	evolution
T3511	13681-13683	VB	denotes	be
T3512	13675-13680	MD	denotes	would
T3513	13684-13691	JJ	denotes	similar
T3514	13692-13694	IN	denotes	to
T3515	13695-13700	DT	denotes	those
T3516	13701-13703	IN	denotes	of
T3517	13704-13709	JJ	denotes	other
T3518	13722-13729	NNS	denotes	members
T3519	13710-13714	NN	denotes	TACC
T3520	13715-13721	NN	denotes	family
T3521	13729-13731	,	denotes	,
T3522	13731-13734	CC	denotes	and
T3523	13735-13738	VB	denotes	fit
T3524	13739-13743	IN	denotes	with
T3525	13744-13747	DT	denotes	the
T3526	13757-13766	NN	denotes	evolution
T3527	13748-13756	VBN	denotes	proposed
T3528	13767-13769	IN	denotes	of
T3529	13770-13773	DT	denotes	the
T3530	13785-13791	NN	denotes	genome
T3531	13774-13784	NN	denotes	vertebrate
T3532	13791-13792	.	denotes	.
T3533	13792-13957	sentence	denotes	Thus, we set out to identify RHAMM orthologues and related genes in metazoans, so that a more complete phylogeny of the coiled coil super family could be generated.
T3534	13793-13797	RB	denotes	Thus
T3535	13802-13805	VBD	denotes	set
T3536	13797-13799	,	denotes	,
T3537	13799-13801	PRP	denotes	we
T3538	13806-13809	RP	denotes	out
T3539	13810-13812	TO	denotes	to
T3540	13813-13821	VB	denotes	identify
T3541	13822-13827	NN	denotes	RHAMM
T3542	13828-13839	NNS	denotes	orthologues
T3543	13840-13843	CC	denotes	and
T3544	13844-13851	VBN	denotes	related
T3545	13852-13857	NNS	denotes	genes
T3546	13858-13860	IN	denotes	in
T3547	13861-13870	NNS	denotes	metazoans
T3548	13870-13872	,	denotes	,
T3549	13872-13874	IN	denotes	so
T3550	13947-13956	VBN	denotes	generated
T3551	13875-13879	IN	denotes	that
T3552	13880-13881	DT	denotes	a
T3553	13896-13905	NN	denotes	phylogeny
T3554	13882-13886	RBR	denotes	more
T3555	13887-13895	JJ	denotes	complete
T3556	13906-13908	IN	denotes	of
T3557	13909-13912	DT	denotes	the
T3558	13931-13937	NN	denotes	family
T3559	13913-13919	VBN	denotes	coiled
T3560	13920-13924	NN	denotes	coil
T3561	13925-13930	JJ	denotes	super
T3562	13938-13943	MD	denotes	could
T3563	13944-13946	VB	denotes	be
T3564	13956-13957	.	denotes	.
T3565	13957-14093	sentence	denotes	We identified a single RHAMM gene in all deuterostomes for which cDNA and/or genomic sequence was available, including C. intestinalis.
T3566	13958-13960	PRP	denotes	We
T3567	13961-13971	VBD	denotes	identified
T3568	13972-13973	DT	denotes	a
T3569	13987-13991	NN	denotes	gene
T3570	13974-13980	JJ	denotes	single
T3571	13981-13986	NN	denotes	RHAMM
T3572	13992-13994	IN	denotes	in
T3573	13995-13998	DT	denotes	all
T3574	13999-14012	NNS	denotes	deuterostomes
T3575	14013-14016	IN	denotes	for
T3576	14052-14055	VBD	denotes	was
T3577	14017-14022	WDT	denotes	which
T3578	14023-14027	NN	denotes	cDNA
T3579	14043-14051	NN	denotes	sequence
T3580	14028-14031	CC	denotes	and
T3581	14031-14032	HYPH	denotes	/
T3582	14032-14034	CC	denotes	or
T3583	14035-14042	JJ	denotes	genomic
T3584	14056-14065	JJ	denotes	available
T3585	14065-14067	,	denotes	,
T3586	14067-14076	VBG	denotes	including
T3587	14077-14079	NNP	denotes	C.
T3588	14080-14092	NNP	denotes	intestinalis
T3589	14092-14093	.	denotes	.
T3590	14093-14147	sentence	denotes	No RHAMM gene was identified in insects or nematodes.
T3591	14094-14096	DT	denotes	No
T3592	14103-14107	NN	denotes	gene
T3593	14097-14102	NN	denotes	RHAMM
T3594	14112-14122	VBN	denotes	identified
T3595	14108-14111	VBD	denotes	was
T3596	14123-14125	IN	denotes	in
T3597	14126-14133	NNS	denotes	insects
T3598	14134-14136	CC	denotes	or
T3599	14137-14146	NNS	denotes	nematodes
T3600	14146-14147	.	denotes	.
T3601	14147-14316	sentence	denotes	This indicates that the RHAMM/TACC genes diverged after the protostome/deuterostome split 833–933 MYA, but prior to the echinodermata/urochordate divergence (>750 MYA).
T3602	14148-14152	DT	denotes	This
T3603	14153-14162	VBZ	denotes	indicates
T3604	14163-14167	IN	denotes	that
T3605	14189-14197	VBD	denotes	diverged
T3606	14168-14171	DT	denotes	the
T3607	14183-14188	NNS	denotes	genes
T3608	14172-14177	NN	denotes	RHAMM
T3609	14178-14182	NN	denotes	TACC
T3610	14177-14178	HYPH	denotes	/
T3611	14198-14203	IN	denotes	after
T3612	14232-14237	VBD	denotes	split
T3613	14204-14207	DT	denotes	the
T3614	14219-14231	NN	denotes	deuterostome
T3615	14208-14218	NN	denotes	protostome
T3616	14218-14219	HYPH	denotes	/
T3617	14238-14241	CD	denotes	833
T3618	14242-14245	CD	denotes	933
T3619	14241-14242	SYM	denotes	–
T3620	14246-14249	RB	denotes	MYA
T3621	14249-14251	,	denotes	,
T3622	14251-14254	CC	denotes	but
T3623	14255-14260	RB	denotes	prior
T3624	14261-14263	IN	denotes	to
T3625	14264-14267	DT	denotes	the
T3626	14294-14304	NN	denotes	divergence
T3627	14268-14281	NN	denotes	echinodermata
T3628	14282-14293	NN	denotes	urochordate
T3629	14281-14282	HYPH	denotes	/
T3630	14305-14306	-LRB-	denotes	(
T3631	14311-14314	RB	denotes	MYA
T3632	14306-14307	SYM	denotes	>
T3633	14307-14310	CD	denotes	750
T3634	14314-14315	-RRB-	denotes	)
T3635	14315-14316	.	denotes	.
T3636	14316-14594	sentence	denotes	Significantly, sequence and phylogenetic analysis of coiled coil proteins (Fig. 1) clearly shows that RHAMM does not contain a TACC domain and instead forms a distinct family of proteins in the coiled coil superfamily, and is not a direct descendant of the ancestral TACC gene.
T3637	14317-14330	RB	denotes	Significantly
T3638	14408-14413	VBZ	denotes	shows
T3639	14330-14332	,	denotes	,
T3640	14332-14340	NN	denotes	sequence
T3641	14358-14366	NN	denotes	analysis
T3642	14341-14344	CC	denotes	and
T3643	14345-14357	JJ	denotes	phylogenetic
T3644	14367-14369	IN	denotes	of
T3645	14370-14376	VBN	denotes	coiled
T3646	14377-14381	NN	denotes	coil
T3647	14382-14390	NN	denotes	proteins
T3648	14391-14392	-LRB-	denotes	(
T3649	14392-14396	NN	denotes	Fig.
T3650	14397-14398	CD	denotes	1
T3651	14398-14399	-RRB-	denotes	)
T3652	14400-14407	RB	denotes	clearly
T3653	14414-14418	IN	denotes	that
T3654	14434-14441	VB	denotes	contain
T3655	14419-14424	NN	denotes	RHAMM
T3656	14425-14429	VBZ	denotes	does
T3657	14430-14433	RB	denotes	not
T3658	14442-14443	DT	denotes	a
T3659	14449-14455	NN	denotes	domain
T3660	14444-14448	NN	denotes	TACC
T3661	14456-14459	CC	denotes	and
T3662	14460-14467	RB	denotes	instead
T3663	14468-14473	VBZ	denotes	forms
T3664	14474-14475	DT	denotes	a
T3665	14485-14491	NN	denotes	family
T3666	14476-14484	JJ	denotes	distinct
T3667	14492-14494	IN	denotes	of
T3668	14495-14503	NN	denotes	proteins
T3669	14504-14506	IN	denotes	in
T3670	14507-14510	DT	denotes	the
T3671	14523-14534	NN	denotes	superfamily
T3672	14511-14517	VBN	denotes	coiled
T3673	14518-14522	NN	denotes	coil
T3674	14534-14536	,	denotes	,
T3675	14536-14539	CC	denotes	and
T3676	14540-14542	VBZ	denotes	is
T3677	14543-14546	RB	denotes	not
T3678	14547-14548	DT	denotes	a
T3679	14556-14566	NN	denotes	descendant
T3680	14549-14555	JJ	denotes	direct
T3681	14567-14569	IN	denotes	of
T3682	14570-14573	DT	denotes	the
T3683	14589-14593	NN	denotes	gene
T3684	14574-14583	JJ	denotes	ancestral
T3685	14584-14588	NN	denotes	TACC
T3686	14593-14594	.	denotes	.
T4145	14596-14605	NN	denotes	Evolution
T4146	14606-14608	IN	denotes	of
T4147	14609-14612	DT	denotes	the
T4148	14625-14633	NNS	denotes	segments
T4149	14613-14624	JJ	denotes	chromosomal
T4150	14634-14644	VBG	denotes	containing
T4151	14645-14648	DT	denotes	the
T4152	14654-14659	NNS	denotes	genes
T4153	14649-14653	NN	denotes	TACC
T4154	14659-14755	sentence	denotes	The phylogenetic tree of the FGFR genes closely resembles that of the vertebrate TACC1-3 genes.
T4155	14660-14663	DT	denotes	The
T4156	14677-14681	NN	denotes	tree
T4157	14664-14676	JJ	denotes	phylogenetic
T4158	14708-14717	VBZ	denotes	resembles
T4159	14682-14684	IN	denotes	of
T4160	14685-14688	DT	denotes	the
T4161	14694-14699	NNS	denotes	genes
T4162	14689-14693	NN	denotes	FGFR
T4163	14700-14707	RB	denotes	closely
T4164	14718-14722	DT	denotes	that
T4165	14723-14725	IN	denotes	of
T4166	14726-14729	DT	denotes	the
T4167	14749-14754	NNS	denotes	genes
T4168	14730-14740	NN	denotes	vertebrate
T4169	14741-14746	NN	denotes	TACC1
T4170	14746-14747	HYPH	denotes	-
T4171	14747-14748	CD	denotes	3
T4172	14754-14755	.	denotes	.
T4173	14755-15031	sentence	denotes	Recently, detailed analyses of the chromosomal regions containing the FGFR gene family in humans, mouse and the arthopod D. melanogaster have revealed the conservation of paralogous chromosomal segments between these organisms (Fig. 2, [13], Table 1 [see Additional file 1]).
T4174	14756-14764	RB	denotes	Recently
T4175	14898-14906	VBN	denotes	revealed
T4176	14764-14766	,	denotes	,
T4177	14766-14774	JJ	denotes	detailed
T4178	14775-14783	NNS	denotes	analyses
T4179	14784-14786	IN	denotes	of
T4180	14787-14790	DT	denotes	the
T4181	14803-14810	NNS	denotes	regions
T4182	14791-14802	JJ	denotes	chromosomal
T4183	14811-14821	VBG	denotes	containing
T4184	14822-14825	DT	denotes	the
T4185	14836-14842	NN	denotes	family
T4186	14826-14830	NN	denotes	FGFR
T4187	14831-14835	NN	denotes	gene
T4188	14843-14845	IN	denotes	in
T4189	14846-14852	NNS	denotes	humans
T4190	14852-14854	,	denotes	,
T4191	14854-14859	NN	denotes	mouse
T4192	14860-14863	CC	denotes	and
T4193	14864-14867	DT	denotes	the
T4194	14868-14876	NN	denotes	arthopod
T4195	14877-14879	NNP	denotes	D.
T4196	14880-14892	NNP	denotes	melanogaster
T4197	14893-14897	VBP	denotes	have
T4198	14907-14910	DT	denotes	the
T4199	14911-14923	NN	denotes	conservation
T4200	14924-14926	IN	denotes	of
T4201	14927-14937	JJ	denotes	paralogous
T4202	14950-14958	NNS	denotes	segments
T4203	14938-14949	JJ	denotes	chromosomal
T4204	14959-14966	IN	denotes	between
T4205	14967-14972	DT	denotes	these
T4206	14973-14982	NNS	denotes	organisms
T4207	14983-14984	-LRB-	denotes	(
T4208	14998-15003	NN	denotes	Table
T4209	14984-14988	NN	denotes	Fig.
T4210	14989-14990	CD	denotes	2
T4211	14990-14992	,	denotes	,
T4212	14992-14993	-LRB-	denotes	[
T4213	14993-14995	CD	denotes	13
T4214	14995-14996	-RRB-	denotes	]
T4215	14996-14998	,	denotes	,
T4216	15004-15005	CD	denotes	1
T4217	15006-15007	-LRB-	denotes	[
T4218	15007-15010	VB	denotes	see
T4219	15011-15021	JJ	denotes	Additional
T4220	15022-15026	NN	denotes	file
T4221	15027-15028	CD	denotes	1
T4222	15028-15029	-RRB-	denotes	]
T4223	15029-15030	-RRB-	denotes	)
T4224	15030-15031	.	denotes	.
T4225	15031-15340	sentence	denotes	This has provided further support that an ancient chromosomal segment was duplicated twice during vertebrate evolution, with the first duplication that gave rise to the human chromosome 4p16/5q32-ter and human chromosome 8p/10q23-ter ancestors occurring in the early stages after the invertebrate divergence.
T4226	15032-15036	DT	denotes	This
T4227	15041-15049	VBN	denotes	provided
T4228	15037-15040	VBZ	denotes	has
T4229	15050-15057	JJ	denotes	further
T4230	15058-15065	NN	denotes	support
T4231	15066-15070	IN	denotes	that
T4232	15106-15116	VBN	denotes	duplicated
T4233	15071-15073	DT	denotes	an
T4234	15094-15101	NN	denotes	segment
T4235	15074-15081	JJ	denotes	ancient
T4236	15082-15093	JJ	denotes	chromosomal
T4237	15102-15105	VBD	denotes	was
T4238	15117-15122	RB	denotes	twice
T4239	15123-15129	IN	denotes	during
T4240	15130-15140	NN	denotes	vertebrate
T4241	15141-15150	NN	denotes	evolution
T4242	15150-15152	,	denotes	,
T4243	15152-15156	IN	denotes	with
T4244	15157-15160	DT	denotes	the
T4245	15167-15178	NN	denotes	duplication
T4246	15161-15166	JJ	denotes	first
T4247	15276-15285	VBG	denotes	occurring
T4248	15179-15183	WDT	denotes	that
T4249	15184-15188	VBD	denotes	gave
T4250	15189-15193	NN	denotes	rise
T4251	15194-15196	IN	denotes	to
T4252	15197-15200	DT	denotes	the
T4253	15266-15275	NNS	denotes	ancestors
T4254	15201-15206	JJ	denotes	human
T4255	15207-15217	NN	denotes	chromosome
T4256	15228-15231	NN	denotes	ter
T4257	15218-15222	NN	denotes	4p16
T4258	15223-15227	NN	denotes	5q32
T4259	15222-15223	HYPH	denotes	/
T4260	15227-15228	HYPH	denotes	-
T4261	15232-15235	CC	denotes	and
T4262	15236-15241	JJ	denotes	human
T4263	15242-15252	NN	denotes	chromosome
T4264	15262-15265	NN	denotes	ter
T4265	15253-15255	NN	denotes	8p
T4266	15256-15261	NN	denotes	10q23
T4267	15255-15256	HYPH	denotes	/
T4268	15261-15262	HYPH	denotes	-
T4269	15286-15288	IN	denotes	in
T4270	15289-15292	DT	denotes	the
T4271	15299-15305	NNS	denotes	stages
T4272	15293-15298	JJ	denotes	early
T4273	15306-15311	IN	denotes	after
T4274	15312-15315	DT	denotes	the
T4275	15329-15339	NN	denotes	divergence
T4276	15316-15328	NN	denotes	invertebrate
T4277	15339-15340	.	denotes	.
T4278	15340-15558	sentence	denotes	This suggests that the ancestral FGFR-TACC gene pair most probably arose prior to the initial duplication and subsequent divergence of these paralogous chromosomal segments, estimated to have occurred 687 ± 155.7 MYA.
T4279	15341-15345	DT	denotes	This
T4280	15346-15354	VBZ	denotes	suggests
T4281	15355-15359	IN	denotes	that
T4282	15408-15413	VBD	denotes	arose
T4283	15360-15363	DT	denotes	the
T4284	15389-15393	NN	denotes	pair
T4285	15364-15373	JJ	denotes	ancestral
T4286	15374-15378	NN	denotes	FGFR
T4287	15379-15383	NN	denotes	TACC
T4288	15378-15379	HYPH	denotes	-
T4289	15384-15388	NN	denotes	gene
T4290	15394-15398	RBS	denotes	most
T4291	15399-15407	RB	denotes	probably
T4292	15414-15419	JJ	denotes	prior
T4293	15420-15422	IN	denotes	to
T4294	15423-15426	DT	denotes	the
T4295	15435-15446	NN	denotes	duplication
T4296	15427-15434	JJ	denotes	initial
T4297	15447-15450	CC	denotes	and
T4298	15451-15461	JJ	denotes	subsequent
T4299	15462-15472	NN	denotes	divergence
T4300	15473-15475	IN	denotes	of
T4301	15476-15481	DT	denotes	these
T4302	15505-15513	NNS	denotes	segments
T4303	15482-15492	JJ	denotes	paralogous
T4304	15493-15504	JJ	denotes	chromosomal
T4305	15513-15515	,	denotes	,
T4306	15515-15524	VBN	denotes	estimated
T4307	15525-15527	TO	denotes	to
T4308	15533-15541	VBN	denotes	occurred
T4309	15528-15532	VB	denotes	have
T4310	15542-15545	CD	denotes	687
T4311	15548-15553	CD	denotes	155.7
T4312	15546-15547	SYM	denotes	±
T4313	15554-15557	RB	denotes	MYA
T4314	15557-15558	.	denotes	.
T4315	15558-15682	sentence	denotes	This has raised the suggestion that a fourth TACC gene in vertebrates would reside in the same chromosomal region as FGFR4.
T4316	15559-15563	DT	denotes	This
T4317	15568-15574	VBN	denotes	raised
T4318	15564-15567	VBZ	denotes	has
T4319	15575-15578	DT	denotes	the
T4320	15579-15589	NN	denotes	suggestion
T4321	15590-15594	IN	denotes	that
T4322	15635-15641	VB	denotes	reside
T4323	15595-15596	DT	denotes	a
T4324	15609-15613	NN	denotes	gene
T4325	15597-15603	JJ	denotes	fourth
T4326	15604-15608	NN	denotes	TACC
T4327	15614-15616	IN	denotes	in
T4328	15617-15628	NNS	denotes	vertebrates
T4329	15629-15634	MD	denotes	would
T4330	15642-15644	IN	denotes	in
T4331	15645-15648	DT	denotes	the
T4332	15666-15672	NN	denotes	region
T4333	15649-15653	JJ	denotes	same
T4334	15654-15665	JJ	denotes	chromosomal
T4335	15673-15675	IN	denotes	as
T4336	15676-15681	NN	denotes	FGFR4
T4337	15681-15682	.	denotes	.
T4338	15682-15786	sentence	denotes	Indeed this hypothesis has been used in support for the RHAMM gene as a member of the TACC family [10].
T4339	15683-15689	RB	denotes	Indeed
T4340	15715-15719	VBN	denotes	used
T4341	15690-15694	DT	denotes	this
T4342	15695-15705	NN	denotes	hypothesis
T4343	15706-15709	VBZ	denotes	has
T4344	15710-15714	VBN	denotes	been
T4345	15720-15722	IN	denotes	in
T4346	15723-15730	NN	denotes	support
T4347	15731-15734	IN	denotes	for
T4348	15735-15738	DT	denotes	the
T4349	15745-15749	NN	denotes	gene
T4350	15739-15744	NN	denotes	RHAMM
T4351	15750-15752	IN	denotes	as
T4352	15753-15754	DT	denotes	a
T4353	15755-15761	NN	denotes	member
T4354	15762-15764	IN	denotes	of
T4355	15765-15768	DT	denotes	the
T4356	15774-15780	NN	denotes	family
T4357	15769-15773	NN	denotes	TACC
T4358	15781-15782	-LRB-	denotes	[
T4359	15782-15784	CD	denotes	10
T4360	15784-15785	-RRB-	denotes	]
T4361	15785-15786	.	denotes	.
T4362	15786-15861	sentence	denotes	Human RHAMM maps to chromosome 5q32 in a region bounded by GPX3 and NKX2E.
T4363	15787-15792	JJ	denotes	Human
T4364	15793-15798	NN	denotes	RHAMM
T4365	15799-15803	VBZ	denotes	maps
T4366	15804-15806	IN	denotes	to
T4367	15807-15817	NN	denotes	chromosome
T4368	15818-15822	NN	denotes	5q32
T4369	15823-15825	IN	denotes	in
T4370	15826-15827	DT	denotes	a
T4371	15828-15834	NN	denotes	region
T4372	15835-15842	VBN	denotes	bounded
T4373	15843-15845	IN	denotes	by
T4374	15846-15850	NN	denotes	GPX3
T4375	15851-15854	CC	denotes	and
T4376	15855-15860	NN	denotes	NKX2E
T4377	15860-15861	.	denotes	.
T4378	15861-15956	sentence	denotes	These loci separate two clusters of genes on human chromosome 5 that are paralogous with 4p16.
T4379	15862-15867	DT	denotes	These
T4380	15868-15872	NNS	denotes	loci
T4381	15873-15881	VBP	denotes	separate
T4382	15882-15885	CD	denotes	two
T4383	15886-15894	NNS	denotes	clusters
T4384	15895-15897	IN	denotes	of
T4385	15898-15903	NNS	denotes	genes
T4386	15904-15906	IN	denotes	on
T4387	15907-15912	JJ	denotes	human
T4388	15913-15923	NN	denotes	chromosome
T4389	15924-15925	CD	denotes	5
T4390	15926-15930	WDT	denotes	that
T4391	15931-15934	VBP	denotes	are
T4392	15935-15945	JJ	denotes	paralogous
T4393	15946-15950	IN	denotes	with
T4394	15951-15955	CD	denotes	4p16
T4395	15955-15956	.	denotes	.
T4396	15956-16171	sentence	denotes	Interestingly, these three clusters are located on different chromosomes in mouse and rat (Fig. 2), further suggesting that this cluster of genes was transposed into this region after the primate/rodent divergence.
T4397	15957-15970	RB	denotes	Interestingly
T4398	15997-16004	VBN	denotes	located
T4399	15970-15972	,	denotes	,
T4400	15972-15977	DT	denotes	these
T4482	17085-17086	``	denotes	"
T4483	17095-17096	''	denotes	"
T4484	17097-17104	JJ	denotes	compact
T4485	17105-17115	NN	denotes	vertebrate
T4486	17123-17132	VBN	denotes	sequenced
T4487	17133-17135	IN	denotes	to
T4488	17136-17140	NN	denotes	date
T4489	17140-17142	,	denotes	,
T4490	17142-17144	NNP	denotes	T.
T4491	17145-17153	NNP	denotes	rubripes
T4492	17154-17155	-LRB-	denotes	[
T4493	17155-17157	CD	denotes	14
T4494	17157-17158	-RRB-	denotes	]
T4495	17158-17159	.	denotes	.
T4496	17159-17335	sentence	denotes	Although not fully assembled, examination of the genome of T. rubripes confirmed the presence of chromosomal segments paralogous to those found in higher vertebrates (Fig. 2).
T4497	17160-17168	IN	denotes	Although
T4498	17179-17188	VBN	denotes	assembled
T4499	17169-17172	RB	denotes	not
T4500	17173-17178	RB	denotes	fully
T4501	17231-17240	VBD	denotes	confirmed
T4502	17188-17190	,	denotes	,
T4503	17190-17201	NN	denotes	examination
T4504	17202-17204	IN	denotes	of
T4505	17205-17208	DT	denotes	the
T4506	17209-17215	NN	denotes	genome
T4507	17216-17218	IN	denotes	of
T4508	17219-17221	NNP	denotes	T.
T4509	17222-17230	NNP	denotes	rubripes
T4510	17241-17244	DT	denotes	the
T4511	17245-17253	NN	denotes	presence
T4512	17254-17256	IN	denotes	of
T4513	17257-17268	JJ	denotes	chromosomal
T4514	17269-17277	NNS	denotes	segments
T4515	17278-17288	JJ	denotes	paralogous
T4516	17289-17291	IN	denotes	to
T4517	17292-17297	DT	denotes	those
T4518	17298-17303	VBN	denotes	found
T4519	17304-17306	IN	denotes	in
T4520	17307-17313	JJR	denotes	higher
T4521	17314-17325	NNS	denotes	vertebrates
T4522	17326-17327	-LRB-	denotes	(
T4523	17327-17331	NN	denotes	Fig.
T4524	17332-17333	CD	denotes	2
T4525	17333-17334	-RRB-	denotes	)
T4526	17334-17335	.	denotes	.
T4527	17335-17492	sentence	denotes	For instance, the orthologues of GPRK2L and RGS12 are found on T. rubripes scaffold 290 (emb\|CAAB01000290.1), and within 300 kb of each other in human 4p16.
T4528	17336-17339	IN	denotes	For
T4529	17390-17395	VBN	denotes	found
T4530	17340-17348	NN	denotes	instance
T4531	17348-17350	,	denotes	,
T4532	17350-17353	DT	denotes	the
T4533	17354-17365	NNS	denotes	orthologues
T4534	17366-17368	IN	denotes	of
T4535	17369-17375	NN	denotes	GPRK2L
T4536	17376-17379	CC	denotes	and
T4537	17380-17385	NN	denotes	RGS12
T4538	17386-17389	VBP	denotes	are
T4539	17396-17398	IN	denotes	on
T4540	17399-17401	NNP	denotes	T.
T4541	17402-17410	NNP	denotes	rubripes
T4542	17411-17419	NN	denotes	scaffold
T4543	17420-17423	CD	denotes	290
T4544	17424-17425	-LRB-	denotes	(
T4545	17425-17443	NN	denotes	emb\|CAAB01000290.1
T4546	17443-17444	-RRB-	denotes	)
T4547	17444-17446	,	denotes	,
T4548	17446-17449	CC	denotes	and
T4549	17450-17456	IN	denotes	within
T4550	17457-17460	CD	denotes	300
T4551	17461-17463	NN	denotes	kb
T4552	17464-17466	IN	denotes	of
T4553	17467-17471	DT	denotes	each
T4554	17472-17477	JJ	denotes	other
T4555	17478-17480	IN	denotes	in
T4556	17481-17486	JJ	denotes	human
T4557	17487-17491	CD	denotes	4p16
T4558	17491-17492	.	denotes	.
T4559	17492-17620	sentence	denotes	The T. rubripes orthologues of FGFR3, LETM1 and WHSC1 are located on the same 166 kb genomic scaffold 251 (emb\|CAAB01000166.1).
T4560	17493-17496	DT	denotes	The
T4561	17509-17520	NNS	denotes	orthologues
T4562	17497-17499	NNP	denotes	T.
T4563	17500-17508	NNP	denotes	rubripes
T4564	17551-17558	VBN	denotes	located
T4565	17521-17523	IN	denotes	of
T4566	17524-17529	NN	denotes	FGFR3
T4567	17529-17531	,	denotes	,
T4568	17531-17536	NN	denotes	LETM1
T4569	17537-17540	CC	denotes	and
T4570	17541-17546	NN	denotes	WHSC1
T4571	17547-17550	VBP	denotes	are
T4572	17559-17561	IN	denotes	on
T4573	17562-17565	DT	denotes	the
T4574	17586-17594	NN	denotes	scaffold
T4575	17566-17570	JJ	denotes	same
T4576	17571-17574	CD	denotes	166
T4577	17575-17577	NN	denotes	kb
T4578	17578-17585	JJ	denotes	genomic
T4579	17595-17598	CD	denotes	251
T4580	17599-17600	-LRB-	denotes	(
T4581	17600-17618	NN	denotes	emb\|CAAB01000166.1
T4582	17618-17619	-RRB-	denotes	)
T4583	17619-17620	.	denotes	.
T4584	17620-17732	sentence	denotes	Significantly, the three human orthologues of these genes are also located within 300 kb of each other on 4p16.
T4585	17621-17634	RB	denotes	Significantly
T4586	17688-17695	VBN	denotes	located
T4587	17634-17636	,	denotes	,
T4588	17636-17639	DT	denotes	the
T4589	17652-17663	NNS	denotes	orthologues
T4590	17640-17645	CD	denotes	three
T4591	17646-17651	JJ	denotes	human
T4592	17664-17666	IN	denotes	of
T4593	17667-17672	DT	denotes	these
T4594	17673-17678	NNS	denotes	genes
T4595	17679-17682	VBP	denotes	are
T4596	17683-17687	RB	denotes	also
T4597	17696-17702	IN	denotes	within
T4598	17703-17706	CD	denotes	300
T4599	17707-17709	NN	denotes	kb
T4600	17710-17712	IN	denotes	of
T4601	17713-17717	DT	denotes	each
T4602	17718-17723	JJ	denotes	other
T4603	17724-17726	IN	denotes	on
T4604	17727-17731	NN	denotes	4p16
T4605	17731-17732	.	denotes	.
T4606	17732-17824	sentence	denotes	Furthermore, TACC3 and FGFRL map to the overlapping scaffolds 1184/4669 (emb\|CAAB01004668).
T4607	17733-17744	RB	denotes	Furthermore
T4608	17762-17765	VBP	denotes	map
T4609	17744-17746	,	denotes	,
T4610	17746-17751	NN	denotes	TACC3
T4611	17752-17755	CC	denotes	and
T4612	17756-17761	NN	denotes	FGFRL
T4613	17766-17768	IN	denotes	to
T4614	17769-17772	DT	denotes	the
T4615	17785-17794	NNS	denotes	scaffolds
T4616	17773-17784	VBG	denotes	overlapping
T4617	17795-17799	CD	denotes	1184
T4618	17800-17804	CD	denotes	4669
T4619	17799-17800	HYPH	denotes	/
T4620	17805-17806	-LRB-	denotes	(
T4621	17806-17822	NN	denotes	emb\|CAAB01004668
T4622	17822-17823	-RRB-	denotes	)
T4623	17823-17824	.	denotes	.
T4624	17824-18073	sentence	denotes	Similarly, elements of these gene clusters, extending from HMP19 to GPRK6 in human chromosome 5q34-ter are also found in the pufferfish, with the T. rubripes orthologues of NSD1, FGFR4 and a RAB-like gene mapping on scaffold 407 (emb\|CAAB01000407).
T4625	17825-17834	RB	denotes	Similarly
T4626	17937-17942	VBN	denotes	found
T4627	17834-17836	,	denotes	,
T4628	17836-17844	NNS	denotes	elements
T4629	17845-17847	IN	denotes	of
T4630	17848-17853	DT	denotes	these
T4631	17859-17867	NNS	denotes	clusters
T4632	17854-17858	NN	denotes	gene
T4633	17867-17869	,	denotes	,
T4634	17869-17878	VBG	denotes	extending
T4635	17879-17883	IN	denotes	from
T4636	17884-17889	NN	denotes	HMP19
T4637	17890-17892	IN	denotes	to
T4638	17893-17898	NN	denotes	GPRK6
T4639	17899-17901	IN	denotes	in
T4640	17902-17907	JJ	denotes	human
T4641	17908-17918	NN	denotes	chromosome
T4642	17924-17927	NN	denotes	ter
T4643	17919-17923	NN	denotes	5q34
T4644	17923-17924	HYPH	denotes	-
T4645	17928-17931	VBP	denotes	are
T4646	17932-17936	RB	denotes	also
T4647	17943-17945	IN	denotes	in
T4648	17946-17949	DT	denotes	the
T4649	17950-17960	NN	denotes	pufferfish
T4650	17960-17962	,	denotes	,
T4651	17962-17966	IN	denotes	with
T4652	17967-17970	DT	denotes	the
T4653	17983-17994	NNS	denotes	orthologues
T4654	17971-17973	NNP	denotes	T.
T4655	17974-17982	NNP	denotes	rubripes
T4656	17995-17997	IN	denotes	of
T4657	17998-18002	NN	denotes	NSD1
T4658	18002-18004	,	denotes	,
T4659	18004-18009	NN	denotes	FGFR4
T4660	18010-18013	CC	denotes	and
T4661	18014-18015	DT	denotes	a
T4662	18020-18024	JJ	denotes	like
T4663	18016-18019	NN	denotes	RAB
T4664	18019-18020	HYPH	denotes	-
T4665	18030-18037	NN	denotes	mapping
T4666	18025-18029	NN	denotes	gene
T4667	18038-18040	IN	denotes	on
T4668	18041-18049	NN	denotes	scaffold
T4669	18050-18053	CD	denotes	407
T4670	18054-18055	-LRB-	denotes	(
T4671	18055-18071	NN	denotes	emb\|CAAB01000407
T4672	18071-18072	-RRB-	denotes	)
T4673	18072-18073	.	denotes	.
T4674	18073-18170	sentence	denotes	However, there is no evidence for a gene corresponding to a TACC4 gene in any of these clusters.
T4675	18074-18081	RB	denotes	However
T4676	18089-18091	VBZ	denotes	is
T4677	18081-18083	,	denotes	,
T4678	18083-18088	EX	denotes	there
T4679	18092-18094	DT	denotes	no
T4680	18095-18103	NN	denotes	evidence
T4681	18104-18107	IN	denotes	for
T4682	18108-18109	DT	denotes	a
T4683	18110-18114	NN	denotes	gene
T4684	18115-18128	VBG	denotes	corresponding
T4685	18129-18131	IN	denotes	to
T4686	18132-18133	DT	denotes	a
T4687	18140-18144	NN	denotes	gene
T4688	18134-18139	NN	denotes	TACC4
T4689	18145-18147	IN	denotes	in
T4690	18148-18151	DT	denotes	any
T4691	18152-18154	IN	denotes	of
T4692	18155-18160	DT	denotes	these
T4693	18161-18169	NNS	denotes	clusters
T4694	18169-18170	.	denotes	.
T4695	18170-18297	sentence	denotes	As noted above, phylogenetic analysis of the TACC sequences indicate that there are two TACC1 related genes in the pufferfish.
T4696	18171-18173	IN	denotes	As
T4697	18174-18179	VBN	denotes	noted
T4698	18231-18239	VBP	denotes	indicate
T4699	18180-18185	RB	denotes	above
T4700	18185-18187	,	denotes	,
T4701	18187-18199	JJ	denotes	phylogenetic
T4702	18200-18208	NN	denotes	analysis
T4703	18209-18211	IN	denotes	of
T4704	18212-18215	DT	denotes	the
T4705	18221-18230	NNS	denotes	sequences
T4706	18216-18220	NN	denotes	TACC
T4707	18240-18244	IN	denotes	that
T4708	18251-18254	VBP	denotes	are
T4709	18245-18250	EX	denotes	there
T4710	18255-18258	CD	denotes	two
T4711	18273-18278	NNS	denotes	genes
T4712	18259-18264	NN	denotes	TACC1
T4713	18265-18272	VBN	denotes	related
T4714	18279-18281	IN	denotes	in
T4715	18282-18285	DT	denotes	the
T4716	18286-18296	NN	denotes	pufferfish
T4717	18296-18297	.	denotes	.
T4718	18297-18456	sentence	denotes	trTACC1B is located on the 180 kb scaffold 191 (emb\|CAAB01000191.1), which also contains the orthologues of several genes located in human chromosome 8p21-11.
T4719	18298-18306	NN	denotes	trTACC1B
T4720	18310-18317	VBN	denotes	located
T4721	18307-18309	VBZ	denotes	is
T4722	18318-18320	IN	denotes	on
T4723	18321-18324	DT	denotes	the
T4724	18332-18340	NN	denotes	scaffold
T4725	18325-18328	CD	denotes	180
T4726	18329-18331	NN	denotes	kb
T4727	18341-18344	CD	denotes	191
T4728	18345-18346	-LRB-	denotes	(
T4729	18346-18364	NN	denotes	emb\|CAAB01000191.1
T4730	18364-18365	-RRB-	denotes	)
T4731	18365-18367	,	denotes	,
T4732	18367-18372	WDT	denotes	which
T4733	18378-18386	VBZ	denotes	contains
T4734	18373-18377	RB	denotes	also
T4735	18387-18390	DT	denotes	the
T4736	18391-18402	NNS	denotes	orthologues
T4737	18403-18405	IN	denotes	of
T4738	18406-18413	JJ	denotes	several
T4739	18414-18419	NNS	denotes	genes
T4740	18420-18427	VBN	denotes	located
T4741	18428-18430	IN	denotes	in
T4742	18431-18436	JJ	denotes	human
T4743	18448-18452	NN	denotes	8p21
T4744	18437-18447	NN	denotes	chromosome
T4745	18452-18453	HYPH	denotes	-
T4746	18453-18455	CD	denotes	11
T4747	18455-18456	.	denotes	.
T4748	18456-18573	sentence	denotes	Thus, this scaffold represents the more "developed" TACC1 chromosomal segment that is evident in higher vertebrates.
T4749	18457-18461	RB	denotes	Thus
T4750	18477-18487	VBZ	denotes	represents
T4751	18461-18463	,	denotes	,
T4752	18463-18467	DT	denotes	this
T4753	18468-18476	NN	denotes	scaffold
T4754	18488-18491	DT	denotes	the
T4755	18527-18534	NN	denotes	segment
T4756	18492-18496	RBR	denotes	more
T4757	18498-18507	VBN	denotes	developed
T4758	18497-18498	``	denotes	"
T4759	18507-18508	''	denotes	"
T4760	18509-18514	NN	denotes	TACC1
T4761	18515-18526	JJ	denotes	chromosomal
T4762	18535-18539	WDT	denotes	that
T4763	18540-18542	VBZ	denotes	is
T4764	18543-18550	JJ	denotes	evident
T4765	18551-18553	IN	denotes	in
T4766	18554-18560	JJR	denotes	higher
T4767	18561-18572	NNS	denotes	vertebrates
T4768	18572-18573	.	denotes	.
T4769	18573-18667	sentence	denotes	On the other hand, the trTACC1A gene is located in the 396 kb scaffold 12 (emb\|CAAB010012.1).
T4770	18574-18576	IN	denotes	On
T4771	18614-18621	VBN	denotes	located
T4772	18577-18580	DT	denotes	the
T4773	18587-18591	NN	denotes	hand
T4774	18581-18586	JJ	denotes	other
T4775	18591-18593	,	denotes	,
T4776	18593-18596	DT	denotes	the
T4777	18606-18610	NN	denotes	gene
T4778	18597-18605	NN	denotes	trTACC1A
T4779	18611-18613	VBZ	denotes	is
T4780	18622-18624	IN	denotes	in
T4781	18625-18628	DT	denotes	the
T4782	18636-18644	NN	denotes	scaffold
T4783	18629-18632	CD	denotes	396
T4784	18633-18635	NN	denotes	kb
T4785	18645-18647	CD	denotes	12
T4786	18648-18649	-LRB-	denotes	(
T4787	18649-18665	NN	denotes	emb\|CAAB010012.1
T4788	18665-18666	-RRB-	denotes	)
T4789	18666-18667	.	denotes	.
T4790	18667-18865	sentence	denotes	This scaffold also contains the T. rubripes orthologues of MSX1, STX18, D4S234E and the predicted gene LOC118711, in addition to sequences with homology to LOXL, EVC, LOC159291, and the LDB family.
T4791	18668-18672	DT	denotes	This
T4792	18673-18681	NN	denotes	scaffold
T4793	18687-18695	VBZ	denotes	contains
T4794	18682-18686	RB	denotes	also
T4795	18696-18699	DT	denotes	the
T4796	18712-18723	NNS	denotes	orthologues
T4797	18700-18702	NNP	denotes	T.
T4798	18703-18711	NNP	denotes	rubripes
T4799	18724-18726	IN	denotes	of
T4800	18727-18731	NN	denotes	MSX1
T4801	18731-18733	,	denotes	,
T4802	18733-18738	NN	denotes	STX18
T4803	18738-18740	,	denotes	,
T4804	18740-18747	NN	denotes	D4S234E
T4805	18748-18751	CC	denotes	and
T4806	18752-18755	DT	denotes	the
T4807	18766-18770	NN	denotes	gene
T4808	18756-18765	VBN	denotes	predicted
T4809	18771-18780	NN	denotes	LOC118711
T4810	18780-18782	,	denotes	,
T4811	18782-18784	IN	denotes	in
T4812	18785-18793	NN	denotes	addition
T4813	18794-18796	IN	denotes	to
T4814	18797-18806	NNS	denotes	sequences
T4815	18807-18811	IN	denotes	with
T4816	18812-18820	NN	denotes	homology
T4817	18821-18823	IN	denotes	to
T4818	18824-18828	NN	denotes	LOXL
T4819	18828-18830	,	denotes	,
T4820	18830-18833	NN	denotes	EVC
T4821	18833-18835	,	denotes	,
T4822	18835-18844	NN	denotes	LOC159291
T4823	18844-18846	,	denotes	,
T4824	18846-18849	CC	denotes	and
T4825	18850-18853	DT	denotes	the
T4826	18858-18864	NN	denotes	family
T4827	18854-18857	NN	denotes	LDB
T4828	18864-18865	.	denotes	.
T4829	18865-19163	sentence	denotes	Thus, scaffold 12 contains genes found in the regions of human chromosome 4 and 10 that also contain the loci for TACC3 and TACC2, respectively, and may therefore more closely resemble the genomic organization resulting from the initial duplication of the ancestral paralogous chromosomal segment.
T4830	18866-18870	RB	denotes	Thus
T4831	18884-18892	VBZ	denotes	contains
T4832	18870-18872	,	denotes	,
T4833	18872-18880	NN	denotes	scaffold
T4834	18881-18883	CD	denotes	12
T4835	18893-18898	NNS	denotes	genes
T4836	18899-18904	VBN	denotes	found
T4837	18905-18907	IN	denotes	in
T4838	18908-18911	DT	denotes	the
T4839	18912-18919	NNS	denotes	regions
T4840	18920-18922	IN	denotes	of
T4841	18923-18928	JJ	denotes	human
T4842	18940-18941	CD	denotes	4
T4843	18929-18939	NN	denotes	chromosome
T4844	18942-18945	CC	denotes	and
T4845	18946-18948	CD	denotes	10
T4846	18949-18953	WDT	denotes	that
T4847	18959-18966	VBP	denotes	contain
T4848	18954-18958	RB	denotes	also
T4849	18967-18970	DT	denotes	the
T4850	18971-18975	NNS	denotes	loci
T4851	18976-18979	IN	denotes	for
T4852	18980-18985	NN	denotes	TACC3
T4853	18986-18989	CC	denotes	and
T4854	18990-18995	NN	denotes	TACC2
T4855	18995-18997	,	denotes	,
T4856	18997-19009	RB	denotes	respectively
T4857	19009-19011	,	denotes	,
T4858	19011-19014	CC	denotes	and
T4859	19015-19018	MD	denotes	may
T4860	19042-19050	VB	denotes	resemble
T4861	19019-19028	RB	denotes	therefore
T4862	19029-19033	RBR	denotes	more
T4863	19034-19041	RB	denotes	closely
T4864	19051-19054	DT	denotes	the
T4865	19063-19075	NN	denotes	organization
T4866	19055-19062	JJ	denotes	genomic
T4867	19076-19085	VBG	denotes	resulting
T4868	19086-19090	IN	denotes	from
T4869	19091-19094	DT	denotes	the
T4870	19103-19114	NN	denotes	duplication
T4871	19095-19102	JJ	denotes	initial
T4872	19115-19117	IN	denotes	of
T4873	19118-19121	DT	denotes	the
T4874	19155-19162	NN	denotes	segment
T4875	19122-19131	JJ	denotes	ancestral
T4876	19132-19142	JJ	denotes	paralogous
T4877	19143-19154	JJ	denotes	chromosomal
T4878	19162-19163	.	denotes	.
T4879	19163-19293	sentence	denotes	Conserved paralogous clusters may result from the initial clustering of the genes in a relatively small ancestral genomic contig.
T4880	19164-19173	VBN	denotes	Conserved
T4881	19185-19193	NNS	denotes	clusters
T4882	19174-19184	JJ	denotes	paralogous
T4883	19198-19204	VB	denotes	result
T4884	19194-19197	MD	denotes	may
T4885	19205-19209	IN	denotes	from
T4886	19210-19213	DT	denotes	the
T4887	19222-19232	NN	denotes	clustering
T4888	19214-19221	JJ	denotes	initial
T4889	19233-19235	IN	denotes	of
T4890	19236-19239	DT	denotes	the
T4891	19240-19245	NNS	denotes	genes
T4892	19246-19248	IN	denotes	in
T4893	19249-19250	DT	denotes	a
T4894	19286-19292	NN	denotes	contig
T4895	19251-19261	RB	denotes	relatively
T4896	19262-19267	JJ	denotes	small
T4897	19268-19277	JJ	denotes	ancestral
T4898	19278-19285	JJ	denotes	genomic
T4899	19292-19293	.	denotes	.
T4900	19293-19499	sentence	denotes	Some evidence for the existence of "protoclusters" that could correspond to the paralogous chromosomal segments noted in higher vertebrates is present in the genome of the urochordate C. intestinalis [11].
T4901	19294-19298	DT	denotes	Some
T4902	19299-19307	NN	denotes	evidence
T4903	19434-19436	VBZ	denotes	is
T4904	19308-19311	IN	denotes	for
T4905	19312-19315	DT	denotes	the
T4906	19316-19325	NN	denotes	existence
T4907	19326-19328	IN	denotes	of
T4908	19329-19330	``	denotes	"
T4909	19330-19343	NNS	denotes	protoclusters
T4910	19343-19344	''	denotes	"
T4911	19345-19349	WDT	denotes	that
T4912	19356-19366	VB	denotes	correspond
T4913	19350-19355	MD	denotes	could
T4914	19367-19369	IN	denotes	to
T4915	19370-19373	DT	denotes	the
T4916	19397-19405	NNS	denotes	segments
T4917	19374-19384	JJ	denotes	paralogous
T4918	19385-19396	JJ	denotes	chromosomal
T4919	19406-19411	VBN	denotes	noted
T4920	19412-19414	IN	denotes	in
T4921	19415-19421	JJR	denotes	higher
T4922	19422-19433	NNS	denotes	vertebrates
T4923	19437-19444	JJ	denotes	present
T4924	19445-19447	IN	denotes	in
T4925	19448-19451	DT	denotes	the
T4926	19452-19458	NN	denotes	genome
T4927	19459-19461	IN	denotes	of
T4928	19462-19465	DT	denotes	the
T4929	19466-19477	NN	denotes	urochordate
T4930	19478-19480	NNP	denotes	C.
T4931	19481-19493	NNP	denotes	intestinalis
T4932	19494-19495	-LRB-	denotes	[
T4933	19495-19497	CD	denotes	11
T4934	19497-19498	-RRB-	denotes	]
T4935	19498-19499	.	denotes	.
T4936	19499-19767	sentence	denotes	For instance, the orthologues of FGFR, and WHSC1, carboxypeptidase Z and FLJ25359 cluster within an 85 kb region of the C. intestinalis genome and the human orthologues are still maintained in paralogous segments of 4p16, 8p and 10q (Fig. 3, [see Additional file 1]).
T4937	19500-19503	IN	denotes	For
T4938	19582-19589	VBP	denotes	cluster
T4939	19504-19512	NN	denotes	instance
T4940	19512-19514	,	denotes	,
T4941	19514-19517	DT	denotes	the
T4942	19518-19529	NNS	denotes	orthologues
T4943	19530-19532	IN	denotes	of
T4944	19533-19537	NN	denotes	FGFR
T4945	19537-19539	,	denotes	,
T4946	19539-19542	CC	denotes	and
T4947	19543-19548	NN	denotes	WHSC1
T4948	19548-19550	,	denotes	,
T4949	19550-19566	NN	denotes	carboxypeptidase
T4950	19567-19568	NN	denotes	Z
T4951	19569-19572	CC	denotes	and
T4952	19573-19581	NN	denotes	FLJ25359
T4953	19590-19596	IN	denotes	within
T4954	19597-19599	DT	denotes	an
T4955	19606-19612	NN	denotes	region
T4956	19600-19602	CD	denotes	85
T4957	19603-19605	NN	denotes	kb
T4958	19613-19615	IN	denotes	of
T4959	19616-19619	DT	denotes	the
T4960	19636-19642	NN	denotes	genome
T4961	19620-19622	NNP	denotes	C.
T4962	19623-19635	NNP	denotes	intestinalis
T4963	19643-19646	CC	denotes	and
T4964	19647-19650	DT	denotes	the
T4965	19657-19668	NNS	denotes	orthologues
T4966	19651-19656	JJ	denotes	human
T4967	19679-19689	VBN	denotes	maintained
T4968	19669-19672	VBP	denotes	are
T4969	19673-19678	RB	denotes	still
T4970	19690-19692	IN	denotes	in
T4971	19693-19703	JJ	denotes	paralogous
T4972	19704-19712	NNS	denotes	segments
T4973	19713-19715	IN	denotes	of
T4974	19716-19720	NN	denotes	4p16
T4975	19720-19722	,	denotes	,
T4976	19722-19724	NN	denotes	8p
T4977	19725-19728	CC	denotes	and
T4978	19729-19732	NN	denotes	10q
T4979	19733-19734	-LRB-	denotes	(
T4980	19734-19738	NN	denotes	Fig.
T4981	19739-19740	CD	denotes	3
T4982	19740-19742	,	denotes	,
T4983	19742-19743	-LRB-	denotes	[
T4984	19743-19746	VB	denotes	see
T4985	19747-19757	JJ	denotes	Additional
T4986	19758-19762	NN	denotes	file
T4987	19763-19764	CD	denotes	1
T4988	19764-19765	-RRB-	denotes	]
T4989	19765-19766	-RRB-	denotes	)
T4990	19766-19767	.	denotes	.
T4991	19767-20135	sentence	denotes	However, it should be noted that no clusters of genes from the vertebrate paralogous segments are locate close to the TACC or RHAMM genes of C. intestinalis, indicating that the formation of the much larger paralogous segments encompassing the FGFR-TACC genes formed later in evolutionary time, or conversely have been subject to extensive rearrangement in tunicates.
T4992	19768-19775	RB	denotes	However
T4993	19790-19795	VBN	denotes	noted
T4994	19775-19777	,	denotes	,
T4995	19777-19779	PRP	denotes	it
T4996	19780-19786	MD	denotes	should
T4997	19787-19789	VB	denotes	be
T4998	19796-19800	IN	denotes	that
T4999	19866-19872	VBN	denotes	locate
T5000	19801-19803	DT	denotes	no
T5001	19804-19812	NNS	denotes	clusters
T5002	19813-19815	IN	denotes	of
T5003	19816-19821	NNS	denotes	genes
T5004	19822-19826	IN	denotes	from
T5005	19827-19830	DT	denotes	the
T5006	19853-19861	NNS	denotes	segments
T5007	19831-19841	NN	denotes	vertebrate
T5008	19842-19852	JJ	denotes	paralogous
T5009	19862-19865	VBP	denotes	are
T5010	19873-19878	RB	denotes	close
T5011	19879-19881	IN	denotes	to
T5012	19882-19885	DT	denotes	the
T5013	19900-19905	NNS	denotes	genes
T5014	19886-19890	NN	denotes	TACC
T5015	19891-19893	CC	denotes	or
T5016	19894-19899	NN	denotes	RHAMM
T5017	19906-19908	IN	denotes	of
T5018	19909-19911	NNP	denotes	C.
T5019	19912-19924	NNP	denotes	intestinalis
T5020	19924-19926	,	denotes	,
T5021	19926-19936	VBG	denotes	indicating
T5022	19937-19941	IN	denotes	that
T5023	20028-20034	VBD	denotes	formed
T5024	19942-19945	DT	denotes	the
T5025	19946-19955	NN	denotes	formation
T5026	19956-19958	IN	denotes	of
T5027	19959-19962	DT	denotes	the
T5028	19986-19994	NNS	denotes	segments
T5029	19963-19967	RB	denotes	much
T5030	19968-19974	JJR	denotes	larger
T5031	19975-19985	JJ	denotes	paralogous
T5032	19995-20007	VBG	denotes	encompassing
T5033	20008-20011	DT	denotes	the
T5034	20022-20027	NNS	denotes	genes
T5035	20012-20016	NN	denotes	FGFR
T5036	20017-20021	NN	denotes	TACC
T5037	20016-20017	HYPH	denotes	-
T5038	20035-20040	RB	denotes	later
T5039	20041-20043	IN	denotes	in
T5040	20044-20056	JJ	denotes	evolutionary
T5041	20057-20061	NN	denotes	time
T5042	20061-20063	,	denotes	,
T5043	20063-20065	CC	denotes	or
T5044	20066-20076	RB	denotes	conversely
T5045	20082-20086	VBN	denotes	been
T5046	20077-20081	VBP	denotes	have
T5047	20087-20094	JJ	denotes	subject
T5048	20095-20097	IN	denotes	to
T5049	20098-20107	JJ	denotes	extensive
T5050	20108-20121	NN	denotes	rearrangement
T5051	20122-20124	IN	denotes	in
T5052	20125-20134	NNS	denotes	tunicates
T5053	20134-20135	.	denotes	.
T5054	20135-20492	sentence	denotes	In combination with the examination of the T. rubripes genome, this also provides additional evidence that either the second round of duplication of the chromosomal segment that contained the FGFR3/4 ancestor did not include a TACC gene, or that such a gene was lost very early in vertebrate evolution, prior to the divergence of the Gnanthostome lineages.
T5055	20136-20138	IN	denotes	In
T5056	20209-20217	VBZ	denotes	provides
T5057	20139-20150	NN	denotes	combination
T5058	20151-20155	IN	denotes	with
T5059	20156-20159	DT	denotes	the
T5060	20160-20171	NN	denotes	examination
T5061	20172-20174	IN	denotes	of
T5062	20175-20178	DT	denotes	the
T5063	20191-20197	NN	denotes	genome
T5064	20179-20181	NNP	denotes	T.
T5065	20182-20190	NNP	denotes	rubripes
T5066	20197-20199	,	denotes	,
T5067	20199-20203	DT	denotes	this
T5068	20204-20208	RB	denotes	also
T5069	20218-20228	JJ	denotes	additional
T5070	20229-20237	NN	denotes	evidence
T5071	20238-20242	IN	denotes	that
T5072	20353-20360	VB	denotes	include
T5073	20243-20249	CC	denotes	either
T5074	20250-20253	DT	denotes	the
T5075	20261-20266	NN	denotes	round
T5076	20254-20260	JJ	denotes	second
T5077	20267-20269	IN	denotes	of
T5078	20270-20281	NN	denotes	duplication
T5079	20282-20284	IN	denotes	of
T5080	20285-20288	DT	denotes	the
T5081	20301-20308	NN	denotes	segment
T5082	20289-20300	JJ	denotes	chromosomal
T5083	20309-20313	WDT	denotes	that
T5084	20314-20323	VBD	denotes	contained
T5085	20324-20327	DT	denotes	the
T5086	20336-20344	NN	denotes	ancestor
T5087	20328-20333	NN	denotes	FGFR3
T5088	20333-20334	HYPH	denotes	/
T5089	20334-20335	CD	denotes	4
T5090	20345-20348	VBD	denotes	did
T5091	20349-20352	RB	denotes	not
T5092	20361-20362	DT	denotes	a
T5093	20368-20372	NN	denotes	gene
T5094	20363-20367	NN	denotes	TACC
T5095	20372-20374	,	denotes	,
T5096	20374-20376	CC	denotes	or
T5097	20377-20381	IN	denotes	that
T5098	20398-20402	VBN	denotes	lost
T5099	20382-20386	PDT	denotes	such
T5100	20389-20393	NN	denotes	gene
T5101	20387-20388	DT	denotes	a
T5102	20394-20397	VBD	denotes	was
T5103	20403-20407	RB	denotes	very
T5104	20408-20413	RB	denotes	early
T5105	20414-20416	IN	denotes	in
T5106	20417-20427	NN	denotes	vertebrate
T5107	20428-20437	NN	denotes	evolution
T5108	20437-20439	,	denotes	,
T5109	20439-20444	RB	denotes	prior
T5110	20445-20447	IN	denotes	to
T5111	20448-20451	DT	denotes	the
T5112	20452-20462	NN	denotes	divergence
T5113	20463-20465	IN	denotes	of
T5114	20466-20469	DT	denotes	the
T5115	20483-20491	NNS	denotes	lineages
T5116	20470-20482	NNP	denotes	Gnanthostome
T5117	20491-20492	.	denotes	.
T5118	20492-20773	sentence	denotes	However, the final resolution of the initial evolution of these paralogous segment will await the sequencing of the amphioxus and lamprey genomes, which only have one FGFR gene, and therefore should only contain one copy of the other corresponding genes in this conserved segment.
T5119	20493-20500	RB	denotes	However
T5161	20727-20740	VBG	denotes	corresponding
T5162	20747-20749	IN	denotes	in
T5163	20750-20754	DT	denotes	this
T5164	20765-20772	NN	denotes	segment
T5165	20755-20764	VBN	denotes	conserved
T5166	20772-20773	.	denotes	.
T5507	21932-21943	JJ	denotes	Comparative
T5508	21952-21961	NN	denotes	structure
T5509	21944-21951	JJ	denotes	genomic
T5510	21962-21964	IN	denotes	of
T5511	21965-21968	DT	denotes	the
T5512	21974-21980	NN	denotes	family
T5513	21969-21973	NN	denotes	TACC
T5514	21980-22236	sentence	denotes	The genomic DNA sequences corresponding to the orthologous TACC genes of human, mouse, rat, pufferfish, C. intestinalis, D. melanogaster and C. elegans were extracted and analyzed by Genescan and BLAST to determine the genomic structure of each TACC gene.
T5515	21981-21984	DT	denotes	The
T5516	21997-22006	NNS	denotes	sequences
T5517	21985-21992	JJ	denotes	genomic
T5518	21993-21996	NN	denotes	DNA
T5519	22138-22147	VBN	denotes	extracted
T5520	22007-22020	VBG	denotes	corresponding
T5521	22021-22023	IN	denotes	to
T5522	22024-22027	DT	denotes	the
T5523	22045-22050	NNS	denotes	genes
T5524	22028-22039	JJ	denotes	orthologous
T5525	22040-22044	NN	denotes	TACC
T5526	22051-22053	IN	denotes	of
T5527	22054-22059	JJ	denotes	human
T5528	22059-22061	,	denotes	,
T5529	22061-22066	NN	denotes	mouse
T5530	22066-22068	,	denotes	,
T5531	22068-22071	NN	denotes	rat
T5532	22071-22073	,	denotes	,
T5533	22073-22083	NN	denotes	pufferfish
T5534	22083-22085	,	denotes	,
T5535	22085-22087	NNP	denotes	C.
T5536	22088-22100	NNP	denotes	intestinalis
T5537	22100-22102	,	denotes	,
T5538	22102-22104	NNP	denotes	D.
T5539	22105-22117	NNP	denotes	melanogaster
T5540	22118-22121	CC	denotes	and
T5541	22122-22124	NNP	denotes	C.
T5542	22125-22132	NNP	denotes	elegans
T5543	22133-22137	VBD	denotes	were
T5544	22148-22151	CC	denotes	and
T5545	22152-22160	VBN	denotes	analyzed
T5546	22161-22163	IN	denotes	by
T5547	22164-22172	NNP	denotes	Genescan
T5548	22173-22176	CC	denotes	and
T5549	22177-22182	NNP	denotes	BLAST
T5550	22183-22185	TO	denotes	to
T5551	22186-22195	VB	denotes	determine
T5552	22196-22199	DT	denotes	the
T5553	22208-22217	NN	denotes	structure
T5554	22200-22207	JJ	denotes	genomic
T5555	22218-22220	IN	denotes	of
T5556	22221-22225	DT	denotes	each
T5557	22231-22235	NN	denotes	gene
T5558	22226-22230	NN	denotes	TACC
T5559	22235-22236	.	denotes	.
T5560	22236-22403	sentence	denotes	In some cases, for rat and pufferfish, exons were added or modified based on the best similarity of translated peptides to the corresponding mouse and human proteins.
T5561	22237-22239	IN	denotes	In
T5562	22287-22292	VBN	denotes	added
T5563	22240-22244	DT	denotes	some
T5564	22245-22250	NNS	denotes	cases
T5565	22250-22252	,	denotes	,
T5566	22252-22255	IN	denotes	for
T5567	22256-22259	NN	denotes	rat
T5568	22260-22263	CC	denotes	and
T5569	22264-22274	NN	denotes	pufferfish
T5570	22274-22276	,	denotes	,
T5571	22276-22281	NNS	denotes	exons
T5572	22282-22286	VBD	denotes	were
T5573	22293-22295	CC	denotes	or
T5574	22296-22304	VBN	denotes	modified
T5575	22305-22310	VBN	denotes	based
T5576	22311-22313	IN	denotes	on
T5577	22314-22317	DT	denotes	the
T5578	22323-22333	NN	denotes	similarity
T5579	22318-22322	JJS	denotes	best
T5580	22334-22336	IN	denotes	of
T5581	22337-22347	VBN	denotes	translated
T5582	22348-22356	NNS	denotes	peptides
T5583	22357-22359	IN	denotes	to
T5584	22360-22363	DT	denotes	the
T5585	22394-22402	NN	denotes	proteins
T5586	22364-22377	VBG	denotes	corresponding
T5587	22378-22383	NN	denotes	mouse
T5588	22384-22387	CC	denotes	and
T5589	22388-22393	JJ	denotes	human
T5590	22402-22403	.	denotes	.
T5591	22403-22596	sentence	denotes	For regions with low sequence similarity in T. rubripes, genomic sequences from the fresh water pufferfish, Tetraodon nigroviridis were used as additional means to verify the predicted exons.
T5592	22404-22407	IN	denotes	For
T5593	22541-22545	VBN	denotes	used
T5594	22408-22415	NNS	denotes	regions
T5595	22416-22420	IN	denotes	with
T5596	22421-22424	JJ	denotes	low
T5597	22434-22444	NN	denotes	similarity
T5598	22425-22433	NN	denotes	sequence
T5599	22445-22447	IN	denotes	in
T5600	22448-22450	NNP	denotes	T.
T5601	22451-22459	NNP	denotes	rubripes
T5602	22459-22461	,	denotes	,
T5603	22461-22468	JJ	denotes	genomic
T5604	22469-22478	NNS	denotes	sequences
T5605	22480-22484	IN	denotes	from
T5606	22485-22488	DT	denotes	the
T5607	22501-22511	NN	denotes	pufferfish
T5608	22489-22494	JJ	denotes	fresh
T5609	22495-22500	NN	denotes	water
T5610	22511-22513	,	denotes	,
T5611	22513-22522	NNP	denotes	Tetraodon
T5612	22523-22535	NNP	denotes	nigroviridis
T5613	22536-22540	VBD	denotes	were
T5614	22546-22548	IN	denotes	as
T5615	22549-22559	JJ	denotes	additional
T5616	22560-22565	NNS	denotes	means
T5617	22566-22568	TO	denotes	to
T5618	22569-22575	VB	denotes	verify
T5619	22576-22579	DT	denotes	the
T5620	22590-22595	NNS	denotes	exons
T5621	22580-22589	VBN	denotes	predicted
T5622	22595-22596	.	denotes	.
T5623	22596-22672	sentence	denotes	The general structure of the TACC genes and proteins is depicted in Fig. 4.
T5624	22597-22600	DT	denotes	The
T5625	22609-22618	NN	denotes	structure
T5626	22601-22608	JJ	denotes	general
T5627	22653-22661	VBN	denotes	depicted
T5628	22619-22621	IN	denotes	of
T5629	22622-22625	DT	denotes	the
T5630	22631-22636	NNS	denotes	genes
T5631	22626-22630	NN	denotes	TACC
T5632	22637-22640	CC	denotes	and
T5633	22641-22649	NN	denotes	proteins
T5634	22650-22652	VBZ	denotes	is
T5635	22662-22664	IN	denotes	in
T5636	22665-22669	NN	denotes	Fig.
T5637	22670-22671	CD	denotes	4
T5638	22671-22672	.	denotes	.
T5639	22672-22787	sentence	denotes	The main conserved feature of the TACC family, the TACC domain, is located at the carboxy terminus of the protein.
T5640	22673-22676	DT	denotes	The
T5641	22692-22699	NN	denotes	feature
T5642	22677-22681	JJ	denotes	main
T5643	22682-22691	VBN	denotes	conserved
T5644	22740-22747	VBN	denotes	located
T5645	22700-22702	IN	denotes	of
T5646	22703-22706	DT	denotes	the
T5647	22712-22718	NN	denotes	family
T5648	22707-22711	NN	denotes	TACC
T5649	22718-22720	,	denotes	,
T5650	22720-22723	DT	denotes	the
T5651	22729-22735	NN	denotes	domain
T5652	22724-22728	NN	denotes	TACC
T5653	22735-22737	,	denotes	,
T5654	22737-22739	VBZ	denotes	is
T5655	22748-22750	IN	denotes	at
T5656	22751-22754	DT	denotes	the
T5657	22763-22771	NN	denotes	terminus
T5658	22755-22762	NN	denotes	carboxy
T5659	22772-22774	IN	denotes	of
T5660	22775-22778	DT	denotes	the
T5661	22779-22786	NN	denotes	protein
T5662	22786-22787	.	denotes	.
T5663	22787-22937	sentence	denotes	In the case of the C. elegans TAC protein, this structure comprises the majority of the protein and is encoded by two of the three exons of the gene.
T5664	22788-22790	IN	denotes	In
T5665	22846-22855	VBZ	denotes	comprises
T5666	22791-22794	DT	denotes	the
T5667	22795-22799	NN	denotes	case
T5668	22800-22802	IN	denotes	of
T5669	22803-22806	DT	denotes	the
T5670	22822-22829	NN	denotes	protein
T5671	22807-22809	NNP	denotes	C.
T5672	22810-22817	NNP	denotes	elegans
T5673	22818-22821	NN	denotes	TAC
T5674	22829-22831	,	denotes	,
T5675	22831-22835	DT	denotes	this
T5676	22836-22845	NN	denotes	structure
T5677	22856-22859	DT	denotes	the
T5678	22860-22868	NN	denotes	majority
T5679	22869-22871	IN	denotes	of
T5680	22872-22875	DT	denotes	the
T5681	22876-22883	NN	denotes	protein
T5682	22884-22887	CC	denotes	and
T5683	22888-22890	VBZ	denotes	is
T5684	22891-22898	VBN	denotes	encoded
T5685	22899-22901	IN	denotes	by
T5686	22902-22905	CD	denotes	two
T5687	22906-22908	IN	denotes	of
T5688	22909-22912	DT	denotes	the
T5689	22919-22924	NNS	denotes	exons
T5690	22913-22918	CD	denotes	three
T5691	22925-22927	IN	denotes	of
T5692	22928-22931	DT	denotes	the
T5693	22932-22936	NN	denotes	gene
T5694	22936-22937	.	denotes	.
T5695	22937-23147	sentence	denotes	In the higher organisms, D. melanogaster, and the deuterostomes C. intestinalis to human, this feature is also encoded by the final exons of the gene (five in D. melanogaster, seven in the deuterostome genes).
T5696	22938-22940	IN	denotes	In
T5697	23049-23056	VBN	denotes	encoded
T5698	22941-22944	DT	denotes	the
T5699	22952-22961	NNS	denotes	organisms
T5700	22945-22951	JJR	denotes	higher
T5701	22961-22963	,	denotes	,
T5702	22963-22965	NNP	denotes	D.
T5703	22966-22978	NNP	denotes	melanogaster
T5704	22978-22980	,	denotes	,
T5705	22980-22983	CC	denotes	and
T5706	22984-22987	DT	denotes	the
T5707	23005-23017	NNP	denotes	intestinalis
T5708	22988-23001	NNS	denotes	deuterostomes
T5709	23002-23004	NNP	denotes	C.
T5710	23018-23020	IN	denotes	to
T5711	23021-23026	JJ	denotes	human
T5712	23026-23028	,	denotes	,
T5713	23028-23032	DT	denotes	this
T5714	23033-23040	NN	denotes	feature
T5715	23041-23043	VBZ	denotes	is
T5716	23044-23048	RB	denotes	also
T5717	23057-23059	IN	denotes	by
T5718	23060-23063	DT	denotes	the
T5719	23070-23075	NNS	denotes	exons
T5720	23064-23069	JJ	denotes	final
T5721	23076-23078	IN	denotes	of
T5722	23079-23082	DT	denotes	the
T5723	23083-23087	NN	denotes	gene
T5724	23088-23089	-LRB-	denotes	(
T5725	23089-23093	CD	denotes	five
T5726	23094-23096	IN	denotes	in
T5727	23097-23099	NNP	denotes	D.
T5728	23100-23112	NNP	denotes	melanogaster
T5729	23112-23114	,	denotes	,
T5730	23114-23119	CD	denotes	seven
T5731	23120-23122	IN	denotes	in
T5732	23123-23126	DT	denotes	the
T5733	23140-23145	NNS	denotes	genes
T5734	23127-23139	NN	denotes	deuterostome
T5735	23145-23146	-RRB-	denotes	)
T5736	23146-23147	.	denotes	.
T5737	23147-23237	sentence	denotes	Outside of the TACC domain, however, TACC family members show relatively little homology.
T5738	23148-23155	IN	denotes	Outside
T5739	23205-23209	VBP	denotes	show
T5740	23156-23158	IN	denotes	of
T5741	23159-23162	DT	denotes	the
T5742	23168-23174	NN	denotes	domain
T5743	23163-23167	NN	denotes	TACC
T5744	23174-23176	,	denotes	,
T5745	23176-23183	RB	denotes	however
T5746	23183-23185	,	denotes	,
T5747	23185-23189	NN	denotes	TACC
T5748	23197-23204	NNS	denotes	members
T5749	23190-23196	NN	denotes	family
T5750	23210-23220	RB	denotes	relatively
T5751	23221-23227	JJ	denotes	little
T5752	23228-23236	NN	denotes	homology
T5753	23236-23237	.	denotes	.
T5754	23237-23455	sentence	denotes	It is interesting that each TACC gene contains one large exon, which shows considerable variability between TACC orthologues, and constitutes the main difference between the TACC3 genes in the vertebrates (see below).
T5755	23238-23240	PRP	denotes	It
T5756	23241-23243	VBZ	denotes	is
T5757	23244-23255	JJ	denotes	interesting
T5758	23256-23260	IN	denotes	that
T5759	23276-23284	VBZ	denotes	contains
T5760	23261-23265	DT	denotes	each
T5761	23271-23275	NN	denotes	gene
T5762	23266-23270	NN	denotes	TACC
T5763	23285-23288	CD	denotes	one
T5764	23295-23299	NN	denotes	exon
T5765	23289-23294	JJ	denotes	large
T5766	23299-23301	,	denotes	,
T5767	23301-23306	WDT	denotes	which
T5768	23307-23312	VBZ	denotes	shows
T5769	23313-23325	JJ	denotes	considerable
T5770	23326-23337	NN	denotes	variability
T5771	23338-23345	IN	denotes	between
T5772	23346-23350	NN	denotes	TACC
T5773	23351-23362	NNS	denotes	orthologues
T5774	23362-23364	,	denotes	,
T5775	23364-23367	CC	denotes	and
T5776	23368-23379	VBZ	denotes	constitutes
T5777	23380-23383	DT	denotes	the
T5778	23389-23399	NN	denotes	difference
T5779	23384-23388	JJ	denotes	main
T5780	23400-23407	IN	denotes	between
T5781	23408-23411	DT	denotes	the
T5782	23418-23423	NNS	denotes	genes
T5783	23412-23417	NN	denotes	TACC3
T5784	23424-23426	IN	denotes	in
T5785	23427-23430	DT	denotes	the
T5786	23431-23442	NNS	denotes	vertebrates
T5787	23443-23444	-LRB-	denotes	(
T5788	23444-23447	VB	denotes	see
T5789	23448-23453	RB	denotes	below
T5790	23453-23454	-RRB-	denotes	)
T5791	23454-23455	.	denotes	.
T5792	23455-23693	sentence	denotes	In deuterostomes, this exon contains the SDP repeat (or in the case of the murine TACC3's, a rodent-specific 24 amino acid repeat), which is responsible for the binding of the SWI/SNF chromatin remodeling complex component GAS41 [15,16].
T5793	23456-23458	IN	denotes	In
T5794	23484-23492	VBZ	denotes	contains
T5795	23459-23472	NNS	denotes	deuterostomes
T5796	23472-23474	,	denotes	,
T5797	23474-23478	DT	denotes	this
T5798	23479-23483	NN	denotes	exon
T5799	23493-23496	DT	denotes	the
T5800	23501-23507	NN	denotes	repeat
T5801	23497-23500	NN	denotes	SDP
T5802	23508-23509	-LRB-	denotes	(
T5803	23509-23511	CC	denotes	or
T5804	23512-23514	IN	denotes	in
T5805	23579-23585	NN	denotes	repeat
T5806	23515-23518	DT	denotes	the
T5807	23519-23523	NN	denotes	case
T5808	23524-23526	IN	denotes	of
T5809	23527-23530	DT	denotes	the
T5810	23538-23543	NN	denotes	TACC3
T5811	23531-23537	JJ	denotes	murine
T5812	23543-23545	POS	denotes	's
T5813	23545-23547	,	denotes	,
T5814	23547-23548	DT	denotes	a
T5815	23549-23555	NN	denotes	rodent
T5816	23556-23564	JJ	denotes	specific
T5817	23555-23556	HYPH	denotes	-
T5818	23565-23567	CD	denotes	24
T5819	23574-23578	NN	denotes	acid
T5820	23568-23573	NN	denotes	amino
T5821	23585-23586	-RRB-	denotes	)
T5822	23586-23588	,	denotes	,
T5823	23588-23593	WDT	denotes	which
T5824	23594-23596	VBZ	denotes	is
T5825	23597-23608	JJ	denotes	responsible
T5826	23609-23612	IN	denotes	for
T5827	23613-23616	DT	denotes	the
T5828	23617-23624	NN	denotes	binding
T5829	23625-23627	IN	denotes	of
T5830	23628-23631	DT	denotes	the
T5831	23669-23678	NN	denotes	component
T5832	23632-23635	NN	denotes	SWI
T5833	23636-23639	NN	denotes	SNF
T5834	23635-23636	HYPH	denotes	/
T5835	23640-23649	NN	denotes	chromatin
T5836	23650-23660	NN	denotes	remodeling
T5837	23661-23668	JJ	denotes	complex
T5838	23679-23684	NN	denotes	GAS41
T5839	23685-23686	-LRB-	denotes	[
T5840	23689-23691	CD	denotes	16
T5841	23686-23688	CD	denotes	15
T5842	23688-23689	,	denotes	,
T5843	23691-23692	-RRB-	denotes	]
T5844	23692-23693	.	denotes	.
T5845	23693-23911	sentence	denotes	Of the vertebrate TACC proteins, the TACC3 orthologues show the greatest variability in size and sequence, ranging in size from 599 amino acids for the rat TACC3 protein, to 942 amino acids in the Danio rerio protein.
T5846	23694-23696	IN	denotes	Of
T5847	23749-23753	VBP	denotes	show
T5848	23697-23700	DT	denotes	the
T5849	23717-23725	NN	denotes	proteins
T5850	23701-23711	NN	denotes	vertebrate
T5851	23712-23716	NN	denotes	TACC
T5852	23725-23727	,	denotes	,
T5853	23727-23730	DT	denotes	the
T5854	23737-23748	NNS	denotes	orthologues
T5855	23731-23736	NN	denotes	TACC3
T5856	23754-23757	DT	denotes	the
T5857	23767-23778	NN	denotes	variability
T5858	23758-23766	JJS	denotes	greatest
T5859	23779-23781	IN	denotes	in
T5860	23782-23786	NN	denotes	size
T5861	23787-23790	CC	denotes	and
T5862	23791-23799	NN	denotes	sequence
T5863	23799-23801	,	denotes	,
T5864	23801-23808	VBG	denotes	ranging
T5865	23809-23811	IN	denotes	in
T5866	23812-23816	NN	denotes	size
T5867	23817-23821	IN	denotes	from
T5868	23822-23825	CD	denotes	599
T5869	23832-23837	NNS	denotes	acids
T5870	23826-23831	NN	denotes	amino
T5871	23838-23841	IN	denotes	for
T5872	23842-23845	DT	denotes	the
T5873	23856-23863	NN	denotes	protein
T5874	23846-23849	NN	denotes	rat
T5875	23850-23855	NN	denotes	TACC3
T5876	23863-23865	,	denotes	,
T5877	23865-23867	IN	denotes	to
T5878	23868-23871	CD	denotes	942
T5879	23878-23883	NNS	denotes	acids
T5880	23872-23877	NN	denotes	amino
T5881	23884-23886	IN	denotes	in
T5882	23887-23890	DT	denotes	the
T5883	23903-23910	NN	denotes	protein
T5884	23891-23896	NNP	denotes	Danio
T5885	23897-23902	NNP	denotes	rerio
T5886	23910-23911	.	denotes	.
T5887	23911-24011	sentence	denotes	The reasons for these differences are apparent from the genomic structure of the TACC3 orthologues.
T5888	23912-23915	DT	denotes	The
T5889	23916-23923	NNS	denotes	reasons
T5890	23946-23949	VBP	denotes	are
T5891	23924-23927	IN	denotes	for
T5892	23928-23933	DT	denotes	these
T5893	23934-23945	NNS	denotes	differences
T5894	23950-23958	JJ	denotes	apparent
T5895	23959-23963	IN	denotes	from
T5896	23964-23967	DT	denotes	the
T5897	23976-23985	NN	denotes	structure
T5898	23968-23975	JJ	denotes	genomic
T5899	23986-23988	IN	denotes	of
T5900	23989-23992	DT	denotes	the
T5901	23999-24010	NNS	denotes	orthologues
T5902	23993-23998	NN	denotes	TACC3
T5903	24010-24011	.	denotes	.
T5904	24011-24270	sentence	denotes	TACC3 can be divided into three sections: a conserved N-terminal region (CNTR) of 108 amino acids, encoded by exons 2 and 3 in each vertebrate TACC3 gene, the conserved TACC domain distributed over the final seven exons, and a highly variable central region.
T5905	24012-24017	NN	denotes	TACC3
T5906	24025-24032	VBN	denotes	divided
T5907	24018-24021	MD	denotes	can
T5908	24022-24024	VB	denotes	be
T5909	24033-24037	IN	denotes	into
T5910	24038-24043	CD	denotes	three
T5911	24044-24052	NNS	denotes	sections
T5912	24052-24054	:	denotes	:
T5913	24054-24055	DT	denotes	a
T5914	24077-24083	NN	denotes	region
T5915	24056-24065	VBN	denotes	conserved
T5916	24066-24067	NN	denotes	N
T5917	24068-24076	JJ	denotes	terminal
T5918	24067-24068	HYPH	denotes	-
T5919	24084-24085	-LRB-	denotes	(
T5920	24085-24089	NN	denotes	CNTR
T5921	24089-24090	-RRB-	denotes	)
T5922	24091-24093	IN	denotes	of
T5923	24094-24097	CD	denotes	108
T5924	24104-24109	NNS	denotes	acids
T5925	24098-24103	NN	denotes	amino
T5926	24109-24111	,	denotes	,
T5927	24111-24118	VBN	denotes	encoded
T5928	24119-24121	IN	denotes	by
T5929	24122-24127	NNS	denotes	exons
T5930	24128-24129	CD	denotes	2
T5931	24130-24133	CC	denotes	and
T5932	24134-24135	CD	denotes	3
T5933	24136-24138	IN	denotes	in
T5934	24139-24143	DT	denotes	each
T5935	24161-24165	NN	denotes	gene
T5936	24144-24154	NN	denotes	vertebrate
T5937	24155-24160	NN	denotes	TACC3
T5938	24165-24167	,	denotes	,
T5939	24167-24170	DT	denotes	the
T5940	24186-24192	NN	denotes	domain
T5941	24171-24180	VBN	denotes	conserved
T5942	24181-24185	NN	denotes	TACC
T5943	24193-24204	VBN	denotes	distributed
T5944	24205-24209	IN	denotes	over
T5945	24210-24213	DT	denotes	the
T5946	24226-24231	NNS	denotes	exons
T5947	24214-24219	JJ	denotes	final
T5948	24220-24225	CD	denotes	seven
T5949	24231-24233	,	denotes	,
T5950	24233-24236	CC	denotes	and
T5951	24237-24238	DT	denotes	a
T5952	24263-24269	NN	denotes	region
T5953	24239-24245	RB	denotes	highly
T5954	24246-24254	JJ	denotes	variable
T5955	24255-24262	JJ	denotes	central
T5956	24269-24270	.	denotes	.
T5957	24270-24485	sentence	denotes	The lack of conservation in both size and sequence of the central portion of the TACC3 proteins of human and mouse has been previously noted, and accounts for the major difference between these two orthologues [2].
T5958	24271-24274	DT	denotes	The
T5959	24275-24279	NN	denotes	lack
T5960	24406-24411	VBN	denotes	noted
T5961	24280-24282	IN	denotes	of
T5962	24283-24295	NN	denotes	conservation
T5963	24296-24298	IN	denotes	in
T5964	24299-24303	CC	denotes	both
T5965	24304-24308	NN	denotes	size
T5966	24309-24312	CC	denotes	and
T5967	24313-24321	NN	denotes	sequence
T5968	24322-24324	IN	denotes	of
T5969	24325-24328	DT	denotes	the
T5970	24337-24344	NN	denotes	portion
T5971	24329-24336	JJ	denotes	central
T5972	24345-24347	IN	denotes	of
T5973	24348-24351	DT	denotes	the
T5974	24358-24366	NN	denotes	proteins
T5975	24352-24357	NN	denotes	TACC3
T5976	24367-24369	IN	denotes	of
T5977	24370-24375	JJ	denotes	human
T5978	24380-24385	NN	denotes	mouse
T5979	24376-24379	CC	denotes	and
T5980	24386-24389	VBZ	denotes	has
T5981	24390-24394	VBN	denotes	been
T5982	24395-24405	RB	denotes	previously
T5983	24411-24413	,	denotes	,
T5984	24413-24416	CC	denotes	and
T5985	24417-24425	VBZ	denotes	accounts
T5986	24426-24429	IN	denotes	for
T5987	24430-24433	DT	denotes	the
T5988	24440-24450	NN	denotes	difference
T5989	24434-24439	JJ	denotes	major
T5990	24451-24458	IN	denotes	between
T5991	24459-24464	DT	denotes	these
T5992	24469-24480	NNS	denotes	orthologues
T5993	24465-24468	CD	denotes	two
T5994	24481-24482	-LRB-	denotes	[
T5995	24482-24483	CD	denotes	2
T5996	24483-24484	-RRB-	denotes	]
T5997	24484-24485	.	denotes	.
T5998	24485-24632	sentence	denotes	The majority of this central portion, which contains the SDP repeat motifs, is encoded by one exon in human and the pufferfish (emb\|CAAB01001184).
T5999	24486-24489	DT	denotes	The
T6000	24490-24498	NN	denotes	majority
T6001	24565-24572	VBN	denotes	encoded
T6002	24499-24501	IN	denotes	of
T6003	24502-24506	DT	denotes	this
T6004	24515-24522	NN	denotes	portion
T6005	24507-24514	JJ	denotes	central
T6006	24522-24524	,	denotes	,
T6007	24524-24529	WDT	denotes	which
T6008	24530-24538	VBZ	denotes	contains
T6009	24539-24542	DT	denotes	the
T6010	24554-24560	NNS	denotes	motifs
T6011	24543-24546	NN	denotes	SDP
T6012	24547-24553	NN	denotes	repeat
T6013	24560-24562	,	denotes	,
T6014	24562-24564	VBZ	denotes	is
T6015	24573-24575	IN	denotes	by
T6016	24576-24579	CD	denotes	one
T6017	24580-24584	NN	denotes	exon
T6018	24585-24587	IN	denotes	in
T6019	24588-24593	JJ	denotes	human
T6020	24594-24597	CC	denotes	and
T6021	24598-24601	DT	denotes	the
T6022	24602-24612	NN	denotes	pufferfish
T6023	24613-24614	-LRB-	denotes	(
T6024	24614-24630	NN	denotes	emb\|CAAB01001184
T6025	24630-24631	-RRB-	denotes	)
T6026	24631-24632	.	denotes	.
T6027	24632-24794	sentence	denotes	In rodents, however, this region is almost entirely composed of seven 24 amino acid repeats, which are located in a single exon of the mouse and rat TACC3 genes.
T6028	24633-24635	IN	denotes	In
T6029	24685-24693	VBN	denotes	composed
T6030	24636-24643	NNS	denotes	rodents
T6031	24643-24645	,	denotes	,
T6032	24645-24652	RB	denotes	however
T6033	24652-24654	,	denotes	,
T6034	24654-24658	DT	denotes	this
T6035	24659-24665	NN	denotes	region
T6036	24666-24668	VBZ	denotes	is
T6037	24669-24675	RB	denotes	almost
T6038	24676-24684	RB	denotes	entirely
T6039	24694-24696	IN	denotes	of
T6040	24697-24702	CD	denotes	seven
T6041	24717-24724	NNS	denotes	repeats
T6042	24703-24705	CD	denotes	24
T6043	24712-24716	NN	denotes	acid
T6044	24706-24711	NN	denotes	amino
T6045	24724-24726	,	denotes	,
T6046	24726-24731	WDT	denotes	which
T6047	24736-24743	VBN	denotes	located
T6048	24732-24735	VBP	denotes	are
T6049	24744-24746	IN	denotes	in
T6050	24747-24748	DT	denotes	a
T6051	24756-24760	NN	denotes	exon
T6052	24749-24755	JJ	denotes	single
T6053	24761-24763	IN	denotes	of
T6054	24764-24767	DT	denotes	the
T6055	24788-24793	NNS	denotes	genes
T6056	24768-24773	NN	denotes	mouse
T6057	24774-24777	CC	denotes	and
T6058	24778-24781	NN	denotes	rat
T6059	24782-24787	NN	denotes	TACC3
T6060	24793-24794	.	denotes	.
T6061	24794-24927	sentence	denotes	It has been previously reported that there are four mouse TACC3 splice variants that differ in the number of these repeats [2,7,17].
T6062	24795-24797	PRP	denotes	It
T6063	24818-24826	VBN	denotes	reported
T6064	24798-24801	VBZ	denotes	has
T6065	24802-24806	VBN	denotes	been
T6066	24807-24817	RB	denotes	previously
T6067	24827-24831	IN	denotes	that
T6068	24838-24841	VBP	denotes	are
T6069	24832-24837	EX	denotes	there
T6070	24842-24846	CD	denotes	four
T6071	24866-24874	NNS	denotes	variants
T6072	24847-24852	NN	denotes	mouse
T6073	24853-24858	NN	denotes	TACC3
T6074	24859-24865	NN	denotes	splice
T6075	24875-24879	WDT	denotes	that
T6076	24880-24886	VBP	denotes	differ
T6077	24887-24889	IN	denotes	in
T6078	24890-24893	DT	denotes	the
T6079	24894-24900	NN	denotes	number
T6080	24901-24903	IN	denotes	of
T6081	24904-24909	DT	denotes	these
T6082	24910-24917	NNS	denotes	repeats
T6083	24918-24919	-LRB-	denotes	[
T6084	24923-24925	CD	denotes	17
T6085	24919-24920	CD	denotes	2
T6086	24920-24921	,	denotes	,
T6087	24921-24922	CD	denotes	7
T6088	24922-24923	,	denotes	,
T6089	24925-24926	-RRB-	denotes	]
T6090	24926-24927	.	denotes	.
T6091	24927-25148	sentence	denotes	As these repeats are present in a single exon, it appears likely that these different sequences may be the result of the DNA polymerases used in the cDNA synthesis and/or PCR reaction stuttering through the repeat motif.
T6092	24928-24930	IN	denotes	As
T6093	24945-24948	VBP	denotes	are
T6094	24931-24936	DT	denotes	these
T6095	24937-24944	NNS	denotes	repeats
T6096	24978-24985	VBZ	denotes	appears
T6097	24949-24956	JJ	denotes	present
T6098	24957-24959	IN	denotes	in
T6099	24960-24961	DT	denotes	a
T6100	24969-24973	NN	denotes	exon
T6101	24962-24968	JJ	denotes	single
T6102	24973-24975	,	denotes	,
T6103	24975-24977	PRP	denotes	it
T6104	24986-24992	JJ	denotes	likely
T6105	24993-24997	IN	denotes	that
T6106	25028-25030	VB	denotes	be
T6107	24998-25003	DT	denotes	these
T6108	25014-25023	NNS	denotes	sequences
T6109	25004-25013	JJ	denotes	different
T6110	25024-25027	MD	denotes	may
T6111	25031-25034	DT	denotes	the
T6112	25035-25041	NN	denotes	result
T6113	25042-25044	IN	denotes	of
T6114	25045-25048	DT	denotes	the
T6115	25053-25064	NNS	denotes	polymerases
T6116	25049-25052	NN	denotes	DNA
T6117	25065-25069	VBN	denotes	used
T6118	25070-25072	IN	denotes	in
T6119	25073-25076	DT	denotes	the
T6120	25082-25091	NN	denotes	synthesis
T6121	25077-25081	NN	denotes	cDNA
T6122	25092-25095	CC	denotes	and
T6123	25095-25096	HYPH	denotes	/
T6124	25096-25098	CC	denotes	or
T6125	25099-25102	NN	denotes	PCR
T6126	25103-25111	NN	denotes	reaction
T6127	25112-25122	VBG	denotes	stuttering
T6128	25123-25130	IN	denotes	through
T6129	25131-25134	DT	denotes	the
T6130	25142-25147	NN	denotes	motif
T6131	25135-25141	NN	denotes	repeat
T6132	25147-25148	.	denotes	.
T6133	25148-25259	sentence	denotes	The correct sequence, reported by Sadek et al [7], is the one used throughout the entirety of this manuscript.
T6134	25149-25152	DT	denotes	The
T6135	25161-25169	NN	denotes	sequence
T6136	25153-25160	JJ	denotes	correct
T6137	25200-25202	VBZ	denotes	is
T6138	25169-25171	,	denotes	,
T6139	25171-25179	VBN	denotes	reported
T6140	25180-25182	IN	denotes	by
T6141	25183-25188	NNP	denotes	Sadek
T6142	25189-25191	FW	denotes	et
T6143	25192-25194	FW	denotes	al
T6144	25195-25196	-LRB-	denotes	[
T6145	25196-25197	CD	denotes	7
T6146	25197-25198	-RRB-	denotes	]
T6147	25198-25200	,	denotes	,
T6148	25203-25206	DT	denotes	the
T6149	25207-25210	CD	denotes	one
T6150	25211-25215	VBN	denotes	used
T6151	25216-25226	IN	denotes	throughout
T6152	25227-25230	DT	denotes	the
T6153	25231-25239	NN	denotes	entirety
T6154	25240-25242	IN	denotes	of
T6155	25243-25247	DT	denotes	this
T6156	25248-25258	NN	denotes	manuscript
T6157	25258-25259	.	denotes	.
T6158	25259-25481	sentence	denotes	These repeats are not evident in the rabbit protein, or any other TACC protein, and may indicate that the rodent TACC3 has evolved distinct functions, as has already been noted for the amphibian Xenopus TACC3, maskin [8].
T6159	25260-25265	DT	denotes	These
T6160	25266-25273	NNS	denotes	repeats
T6161	25274-25277	VBP	denotes	are
T6162	25278-25281	RB	denotes	not
T6163	25282-25289	JJ	denotes	evident
T6164	25290-25292	IN	denotes	in
T6165	25293-25296	DT	denotes	the
T6166	25304-25311	NN	denotes	protein
T6167	25297-25303	NN	denotes	rabbit
T6168	25311-25313	,	denotes	,
T6169	25313-25315	CC	denotes	or
T6170	25316-25319	DT	denotes	any
T6171	25331-25338	NN	denotes	protein
T6172	25320-25325	JJ	denotes	other
T6173	25326-25330	NN	denotes	TACC
T6174	25338-25340	,	denotes	,
T6175	25340-25343	CC	denotes	and
T6176	25344-25347	MD	denotes	may
T6177	25348-25356	VB	denotes	indicate
T6178	25357-25361	IN	denotes	that
T6179	25383-25390	VBN	denotes	evolved
T6180	25362-25365	DT	denotes	the
T6181	25373-25378	NN	denotes	TACC3
T6182	25366-25372	NN	denotes	rodent
T6183	25379-25382	VBZ	denotes	has
T6184	25391-25399	JJ	denotes	distinct
T6185	25400-25409	NNS	denotes	functions
T6186	25409-25411	,	denotes	,
T6187	25411-25413	IN	denotes	as
T6188	25431-25436	VBN	denotes	noted
T6189	25414-25417	VBZ	denotes	has
T6190	25418-25425	RB	denotes	already
T6191	25426-25430	VBN	denotes	been
T6192	25437-25440	IN	denotes	for
T6193	25441-25444	DT	denotes	the
T6194	25463-25468	NN	denotes	TACC3
T6195	25445-25454	JJ	denotes	amphibian
T6196	25455-25462	NNP	denotes	Xenopus
T6197	25468-25470	,	denotes	,
T6198	25470-25476	NN	denotes	maskin
T6199	25477-25478	-LRB-	denotes	[
T6200	25478-25479	CD	denotes	8
T6201	25479-25480	-RRB-	denotes	]
T6202	25480-25481	.	denotes	.
T6381	25483-25494	JJ	denotes	Alternative
T6382	25495-25503	NN	denotes	splicing
T6383	25504-25506	IN	denotes	in
T6384	25507-25517	NN	denotes	vertebrate
T6385	25523-25528	NNS	denotes	genes
T6386	25518-25522	NN	denotes	TACC
T6387	25528-25800	sentence	denotes	Whereas exon shuffling can drive the functional diversification of gene families over evolutionary time, the temporal and/or tissue specific alternative splicing of a gene can give rise to functional diversification of a single gene during the development of an organism.
T6388	25529-25536	IN	denotes	Whereas
T6389	25556-25561	VB	denotes	drive
T6390	25537-25541	NN	denotes	exon
T6391	25542-25551	NN	denotes	shuffling
T6392	25552-25555	MD	denotes	can
T6393	25705-25709	VB	denotes	give
T6394	25562-25565	DT	denotes	the
T6395	25577-25592	NN	denotes	diversification
T6396	25566-25576	JJ	denotes	functional
T6397	25593-25595	IN	denotes	of
T6398	25596-25600	NN	denotes	gene
T6399	25601-25609	NNS	denotes	families
T6400	25610-25614	IN	denotes	over
T6401	25615-25627	JJ	denotes	evolutionary
T6402	25628-25632	NN	denotes	time
T6403	25632-25634	,	denotes	,
T6404	25634-25637	DT	denotes	the
T6405	25682-25690	NN	denotes	splicing
T6406	25638-25646	JJ	denotes	temporal
T6407	25647-25650	CC	denotes	and
T6408	25650-25651	HYPH	denotes	/
T6409	25651-25653	CC	denotes	or
T6410	25654-25660	NN	denotes	tissue
T6411	25661-25669	JJ	denotes	specific
T6412	25670-25681	JJ	denotes	alternative
T6413	25691-25693	IN	denotes	of
T6414	25694-25695	DT	denotes	a
T6415	25696-25700	NN	denotes	gene
T6416	25701-25704	MD	denotes	can
T6417	25710-25714	NN	denotes	rise
T6418	25715-25717	IN	denotes	to
T6419	25718-25728	JJ	denotes	functional
T6420	25729-25744	NN	denotes	diversification
T6421	25745-25747	IN	denotes	of
T6422	25748-25749	DT	denotes	a
T6423	25757-25761	NN	denotes	gene
T6424	25750-25756	JJ	denotes	single
T6425	25762-25768	IN	denotes	during
T6426	25769-25772	DT	denotes	the
T6427	25773-25784	NN	denotes	development
T6428	25785-25787	IN	denotes	of
T6429	25788-25790	DT	denotes	an
T6430	25791-25799	NN	denotes	organism
T6431	25799-25800	.	denotes	.
T6432	25800-25956	sentence	denotes	Although no alternative splicing of TACC3 has been clearly documented, both temporal and tissue specific splicing is observed in the TACC1 and TACC2 genes.
T6433	25801-25809	IN	denotes	Although
T6434	25860-25870	VBN	denotes	documented
T6435	25810-25812	DT	denotes	no
T6436	25825-25833	NN	denotes	splicing
T6437	25813-25824	JJ	denotes	alternative
T6438	25834-25836	IN	denotes	of
T6439	25837-25842	NN	denotes	TACC3
T6440	25843-25846	VBZ	denotes	has
T6441	25847-25851	VBN	denotes	been
T6442	25852-25859	RB	denotes	clearly
T6443	25918-25926	VBN	denotes	observed
T6444	25870-25872	,	denotes	,
T6445	25872-25876	CC	denotes	both
T6446	25877-25885	JJ	denotes	temporal
T6447	25906-25914	NN	denotes	splicing
T6448	25886-25889	CC	denotes	and
T6449	25890-25896	NN	denotes	tissue
T6450	25897-25905	JJ	denotes	specific
T6451	25915-25917	VBZ	denotes	is
T6452	25927-25929	IN	denotes	in
T6453	25930-25933	DT	denotes	the
T6454	25950-25955	NNS	denotes	genes
T6455	25934-25939	NN	denotes	TACC1
T6456	25940-25943	CC	denotes	and
T6457	25944-25949	NN	denotes	TACC2
T6458	25955-25956	.	denotes	.
T6459	25956-26112	sentence	denotes	In the case of TACC2, an additional large (5 kb) exon accounts for the main difference between the major splice variants of the vertebrate TACC2 genes [3].
T6460	25957-25959	IN	denotes	In
T6461	26011-26019	VBZ	denotes	accounts
T6462	25960-25963	DT	denotes	the
T6463	25964-25968	NN	denotes	case
T6464	25969-25971	IN	denotes	of
T6465	25972-25977	NN	denotes	TACC2
T6466	25977-25979	,	denotes	,
T6467	25979-25981	DT	denotes	an
T6468	26006-26010	NN	denotes	exon
T6469	25982-25992	JJ	denotes	additional
T6470	25993-25998	JJ	denotes	large
T6471	25999-26000	-LRB-	denotes	(
T6472	26002-26004	NN	denotes	kb
T6473	26000-26001	CD	denotes	5
T6474	26004-26005	-RRB-	denotes	)
T6475	26020-26023	IN	denotes	for
T6476	26024-26027	DT	denotes	the
T6477	26033-26043	NN	denotes	difference
T6478	26028-26032	JJ	denotes	main
T6479	26044-26051	IN	denotes	between
T6480	26052-26055	DT	denotes	the
T6481	26069-26077	NNS	denotes	variants
T6482	26056-26061	JJ	denotes	major
T6483	26062-26068	NN	denotes	splice
T6484	26078-26080	IN	denotes	of
T6485	26081-26084	DT	denotes	the
T6486	26102-26107	NNS	denotes	genes
T6487	26085-26095	NN	denotes	vertebrate
T6488	26096-26101	NN	denotes	TACC2
T6489	26108-26109	-LRB-	denotes	[
T6490	26109-26110	CD	denotes	3
T6491	26110-26111	-RRB-	denotes	]
T6492	26111-26112	.	denotes	.
T6493	26112-26339	sentence	denotes	The alternative splicing of this exon suggests a major functional difference between the two TACC2 isoforms, TACC2s and TACC2l [3], as well as a significant difference between TACC2 and its closest TACC family relative, TACC1.
T6494	26113-26116	DT	denotes	The
T6495	26129-26137	NN	denotes	splicing
T6496	26117-26128	JJ	denotes	alternative
T6497	26151-26159	VBZ	denotes	suggests
T6498	26138-26140	IN	denotes	of
T6499	26141-26145	DT	denotes	this
T6500	26146-26150	NN	denotes	exon
T6501	26160-26161	DT	denotes	a
T6502	26179-26189	NN	denotes	difference
T6503	26162-26167	JJ	denotes	major
T6504	26168-26178	JJ	denotes	functional
T6505	26190-26197	IN	denotes	between
T6506	26198-26201	DT	denotes	the
T6507	26212-26220	NNS	denotes	isoforms
T6508	26202-26205	CD	denotes	two
T6509	26206-26211	NN	denotes	TACC2
T6510	26220-26222	,	denotes	,
T6511	26222-26228	NNS	denotes	TACC2s
T6512	26229-26232	CC	denotes	and
T6513	26233-26239	NN	denotes	TACC2l
T6514	26240-26241	-LRB-	denotes	[
T6515	26241-26242	CD	denotes	3
T6516	26242-26243	-RRB-	denotes	]
T6517	26243-26245	,	denotes	,
T6518	26245-26247	RB	denotes	as
T6519	26253-26255	IN	denotes	as
T6520	26248-26252	RB	denotes	well
T6521	26256-26257	DT	denotes	a
T6522	26270-26280	NN	denotes	difference
T6523	26258-26269	JJ	denotes	significant
T6524	26281-26288	IN	denotes	between
T6525	26289-26294	NN	denotes	TACC2
T6526	26295-26298	CC	denotes	and
T6527	26299-26302	PRP$	denotes	its
T6528	26323-26331	NN	denotes	relative
T6529	26303-26310	JJS	denotes	closest
T6530	26311-26315	NN	denotes	TACC
T6531	26316-26322	NN	denotes	family
T6532	26331-26333	,	denotes	,
T6533	26333-26338	NN	denotes	TACC1
T6534	26338-26339	.	denotes	.
T6535	26339-26418	sentence	denotes	However, the function of this region of the TACC2l isoform is current unknown.
T6536	26340-26347	RB	denotes	However
T6537	26399-26401	VBZ	denotes	is
T6538	26347-26349	,	denotes	,
T6539	26349-26352	DT	denotes	the
T6540	26353-26361	NN	denotes	function
T6541	26362-26364	IN	denotes	of
T6542	26365-26369	DT	denotes	this
T6543	26370-26376	NN	denotes	region
T6544	26377-26379	IN	denotes	of
T6545	26380-26383	DT	denotes	the
T6546	26391-26398	NN	denotes	isoform
T6547	26384-26390	NN	denotes	TACC2l
T6548	26402-26409	RB	denotes	current
T6549	26410-26417	JJ	denotes	unknown
T6550	26417-26418	.	denotes	.
T6551	26418-26539	sentence	denotes	Alternative splicing, together with differential promoter usage has already been noted for the human TACC1 gene [18,19].
T6552	26419-26430	JJ	denotes	Alternative
T6553	26431-26439	NN	denotes	splicing
T6554	26500-26505	VBN	denotes	noted
T6555	26439-26441	,	denotes	,
T6556	26441-26449	RB	denotes	together
T6557	26450-26454	IN	denotes	with
T6558	26455-26467	JJ	denotes	differential
T6559	26477-26482	NN	denotes	usage
T6560	26468-26476	NN	denotes	promoter
T6561	26483-26486	VBZ	denotes	has
T6562	26487-26494	RB	denotes	already
T6563	26495-26499	VBN	denotes	been
T6564	26506-26509	IN	denotes	for
T6565	26510-26513	DT	denotes	the
T6566	26526-26530	NN	denotes	gene
T6567	26514-26519	JJ	denotes	human
T6568	26520-26525	NN	denotes	TACC1
T6569	26531-26532	-LRB-	denotes	[
T6570	26535-26537	CD	denotes	19
T6571	26532-26534	CD	denotes	18
T6572	26534-26535	,	denotes	,
T6573	26537-26538	-RRB-	denotes	]
T6574	26538-26539	.	denotes	.
T6575	26539-26671	sentence	denotes	In addition, as shown in Fig. 5, we have identified additional TACC1 isoforms that result from alternative splicing of exons 1b-4a.
T6576	26540-26542	IN	denotes	In
T6577	26581-26591	VBN	denotes	identified
T6578	26543-26551	NN	denotes	addition
T6579	26551-26553	,	denotes	,
T6580	26553-26555	IN	denotes	as
T6581	26556-26561	VBN	denotes	shown
T6582	26562-26564	IN	denotes	in
T6583	26565-26569	NN	denotes	Fig.
T6584	26570-26571	CD	denotes	5
T6585	26571-26573	,	denotes	,
T6586	26573-26575	PRP	denotes	we
T6587	26576-26580	VBP	denotes	have
T6588	26592-26602	JJ	denotes	additional
T6589	26609-26617	NNS	denotes	isoforms
T6590	26603-26608	NN	denotes	TACC1
T6591	26618-26622	WDT	denotes	that
T6592	26623-26629	VBP	denotes	result
T6593	26630-26634	IN	denotes	from
T6594	26635-26646	JJ	denotes	alternative
T6595	26647-26655	NN	denotes	splicing
T6596	26656-26658	IN	denotes	of
T6597	26659-26664	NNS	denotes	exons
T6598	26668-26670	CD	denotes	4a
T6599	26665-26667	CD	denotes	1b
T6600	26667-26668	HYPH	denotes	-
T6601	26670-26671	.	denotes	.
T6602	26671-26955	sentence	denotes	The functions of these different isoforms are unknown, however the region deleted from the shorter variants can include the binding site for LSm7 [20] (variants C, D, F-I), and/or the nuclear localization signals and binding site for GAS41 [15] and PCTAIRE2BP [20] (isoforms B-D, S).
T6603	26672-26675	DT	denotes	The
T6604	26676-26685	NNS	denotes	functions
T6605	26714-26717	VBP	denotes	are
T6606	26686-26688	IN	denotes	of
T6607	26689-26694	DT	denotes	these
T6608	26705-26713	NNS	denotes	isoforms
T6609	26695-26704	JJ	denotes	different
T6610	26784-26791	VB	denotes	include
T6611	26718-26725	JJ	denotes	unknown
T6612	26725-26727	,	denotes	,
T6613	26727-26734	RB	denotes	however
T6614	26735-26738	DT	denotes	the
T6615	26739-26745	NN	denotes	region
T6616	26746-26753	VBN	denotes	deleted
T6617	26754-26758	IN	denotes	from
T6618	26759-26762	DT	denotes	the
T6619	26771-26779	NNS	denotes	variants
T6620	26763-26770	JJR	denotes	shorter
T6621	26780-26783	MD	denotes	can
T6622	26792-26795	DT	denotes	the
T6623	26804-26808	NN	denotes	site
T6624	26796-26803	NN	denotes	binding
T6625	26809-26812	IN	denotes	for
T6626	26813-26817	NN	denotes	LSm7
T6627	26818-26819	-LRB-	denotes	[
T6628	26819-26821	CD	denotes	20
T6629	26821-26822	-RRB-	denotes	]
T6630	26823-26824	-LRB-	denotes	(
T6631	26833-26834	NN	denotes	C
T6632	26824-26832	NNS	denotes	variants
T6633	26834-26836	,	denotes	,
T6634	26836-26837	NN	denotes	D
T6635	26837-26839	,	denotes	,
T6636	26839-26840	NN	denotes	F
T6637	26840-26841	SYM	denotes	-
T6638	26841-26842	NN	denotes	I
T6639	26842-26843	-RRB-	denotes	)
T6640	26843-26845	,	denotes	,
T6641	26845-26848	CC	denotes	and
T6642	26848-26849	HYPH	denotes	/
T6643	26849-26851	CC	denotes	or
T6644	26852-26855	DT	denotes	the
T6645	26877-26884	NNS	denotes	signals
T6646	26856-26863	JJ	denotes	nuclear
T6647	26864-26876	NN	denotes	localization
T6648	26885-26888	CC	denotes	and
T6649	26889-26896	NN	denotes	binding
T6650	26897-26901	NN	denotes	site
T6651	26902-26905	IN	denotes	for
T6652	26906-26911	NN	denotes	GAS41
T6653	26912-26913	-LRB-	denotes	[
T6654	26913-26915	CD	denotes	15
T6655	26915-26916	-RRB-	denotes	]
T6656	26917-26920	CC	denotes	and
T6657	26921-26931	NN	denotes	PCTAIRE2BP
T6658	26932-26933	-LRB-	denotes	[
T6659	26933-26935	CD	denotes	20
T6660	26935-26936	-RRB-	denotes	]
T6661	26937-26938	-LRB-	denotes	(
T6662	26947-26948	NN	denotes	B
T6663	26938-26946	NNS	denotes	isoforms
T6664	26948-26949	SYM	denotes	-
T6665	26949-26950	NN	denotes	D
T6666	26950-26952	,	denotes	,
T6667	26952-26953	NN	denotes	S
T6668	26953-26954	-RRB-	denotes	)
T6669	26954-26955	.	denotes	.
T6670	26955-27189	sentence	denotes	One of these isoforms, TACC1S is localized exclusively to the cytoplasm [19], suggesting that the shorter isoforms would not be able to interact with elements of the chomatin remodeling and/or RNA processing machinery in the nucleus.
T6671	26956-26959	CD	denotes	One
T6672	26989-26998	VBN	denotes	localized
T6673	26960-26962	IN	denotes	of
T6674	26963-26968	DT	denotes	these
T6675	26969-26977	NNS	denotes	isoforms
T6676	26977-26979	,	denotes	,
T6677	26979-26985	NN	denotes	TACC1S
T6678	26986-26988	VBZ	denotes	is
T6679	26999-27010	RB	denotes	exclusively
T6680	27011-27013	IN	denotes	to
T6681	27014-27017	DT	denotes	the
T6682	27018-27027	NN	denotes	cytoplasm
T6683	27028-27029	-LRB-	denotes	[
T6684	27029-27031	CD	denotes	19
T6685	27031-27032	-RRB-	denotes	]
T6686	27032-27034	,	denotes	,
T6687	27034-27044	VBG	denotes	suggesting
T6688	27045-27049	IN	denotes	that
T6689	27081-27083	VB	denotes	be
T6690	27050-27053	DT	denotes	the
T6691	27062-27070	NNS	denotes	isoforms
T6692	27054-27061	JJR	denotes	shorter
T6693	27071-27076	MD	denotes	would
T6694	27077-27080	RB	denotes	not
T6695	27084-27088	JJ	denotes	able
T6696	27089-27091	TO	denotes	to
T6697	27092-27100	VB	denotes	interact
T6698	27101-27105	IN	denotes	with
T6699	27106-27114	NNS	denotes	elements
T6700	27115-27117	IN	denotes	of
T6701	27118-27121	DT	denotes	the
T6702	27131-27141	NN	denotes	remodeling
T6703	27122-27130	NN	denotes	chomatin
T6704	27142-27145	CC	denotes	and
T6705	27145-27146	HYPH	denotes	/
T6706	27146-27148	CC	denotes	or
T6707	27149-27152	NN	denotes	RNA
T6708	27164-27173	NN	denotes	machinery
T6709	27153-27163	NN	denotes	processing
T6710	27174-27176	IN	denotes	in
T6711	27177-27180	DT	denotes	the
T6712	27181-27188	NN	denotes	nucleus
T6713	27188-27189	.	denotes	.
T6714	27189-27456	sentence	denotes	Thus, changes in the complement of TACC1 isoforms in the cell may result in alterations in cellular RNA metabolism at multiple levels, and may account for the observation that TACC1D and TACC1F isoforms are associated with tumorigenic changes in gastric mucosa [18].
T6715	27190-27194	RB	denotes	Thus
T6716	27256-27262	VB	denotes	result
T6717	27194-27196	,	denotes	,
T6718	27196-27203	NNS	denotes	changes
T6719	27204-27206	IN	denotes	in
T6720	27207-27210	DT	denotes	the
T6721	27211-27221	NN	denotes	complement
T6722	27222-27224	IN	denotes	of
T6723	27225-27230	NN	denotes	TACC1
T6724	27231-27239	NNS	denotes	isoforms
T6725	27240-27242	IN	denotes	in
T6726	27243-27246	DT	denotes	the
T6727	27247-27251	NN	denotes	cell
T6728	27252-27255	MD	denotes	may
T6729	27263-27265	IN	denotes	in
T6730	27266-27277	NNS	denotes	alterations
T6731	27278-27280	IN	denotes	in
T6732	27281-27289	JJ	denotes	cellular
T6733	27294-27304	NN	denotes	metabolism
T6734	27290-27293	NN	denotes	RNA
T6735	27305-27307	IN	denotes	at
T6736	27308-27316	JJ	denotes	multiple
T6737	27317-27323	NNS	denotes	levels
T6738	27323-27325	,	denotes	,
T6739	27325-27328	CC	denotes	and
T6740	27329-27332	MD	denotes	may
T6741	27333-27340	VB	denotes	account
T6742	27341-27344	IN	denotes	for
T6743	27345-27348	DT	denotes	the
T6744	27349-27360	NN	denotes	observation
T6745	27361-27365	IN	denotes	that
T6746	27397-27407	VBN	denotes	associated
T6747	27366-27372	NN	denotes	TACC1D
T6748	27384-27392	NNS	denotes	isoforms
T6749	27373-27376	CC	denotes	and
T6750	27377-27383	NN	denotes	TACC1F
T6751	27393-27396	VBP	denotes	are
T6752	27408-27412	IN	denotes	with
T6753	27413-27424	JJ	denotes	tumorigenic
T6754	27425-27432	NNS	denotes	changes
T6755	27433-27435	IN	denotes	in
T6756	27436-27443	JJ	denotes	gastric
T6757	27444-27450	NN	denotes	mucosa
T6758	27451-27452	-LRB-	denotes	[
T6759	27452-27454	CD	denotes	18
T6760	27454-27455	-RRB-	denotes	]
T6761	27455-27456	.	denotes	.
T13815	32820-32904	sentence	denotes	In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family.
T7167	28659-28661	FW	denotes	In
T7168	28662-28668	FW	denotes	silico
T7169	28669-28677	NN	denotes	modeling
T7170	28678-28680	IN	denotes	of
T7171	28681-28684	DT	denotes	the
T7172	28685-28694	NN	denotes	evolution
T7173	28695-28697	IN	denotes	of
T7174	28698-28702	NN	denotes	TACC
T7175	28703-28710	NN	denotes	protein
T7176	28711-28719	NN	denotes	function
T7177	28719-28924	sentence	denotes	The protein and genomic structure of the present day TACC family members suggests that the function of the ancestral TACC protein was mediated solely through the interactions of the conserved TACC domain.
T7178	28720-28723	DT	denotes	The
T7179	28744-28753	NN	denotes	structure
T7180	28724-28731	NN	denotes	protein
T7181	28732-28735	CC	denotes	and
T7182	28736-28743	JJ	denotes	genomic
T7183	28793-28801	VBZ	denotes	suggests
T7184	28754-28756	IN	denotes	of
T7185	28757-28760	DT	denotes	the
T7186	28785-28792	NNS	denotes	members
T7187	28761-28768	JJ	denotes	present
T7188	28769-28772	NN	denotes	day
T7189	28773-28777	NN	denotes	TACC
T7190	28778-28784	NN	denotes	family
T7191	28802-28806	IN	denotes	that
T7192	28854-28862	VBN	denotes	mediated
T7193	28807-28810	DT	denotes	the
T7194	28811-28819	NN	denotes	function
T7195	28820-28822	IN	denotes	of
T7196	28823-28826	DT	denotes	the
T7197	28842-28849	NN	denotes	protein
T7198	28827-28836	JJ	denotes	ancestral
T7199	28837-28841	NN	denotes	TACC
T7200	28850-28853	VBD	denotes	was
T7201	28863-28869	RB	denotes	solely
T7202	28870-28877	IN	denotes	through
T7203	28878-28881	DT	denotes	the
T7204	28882-28894	NNS	denotes	interactions
T7205	28895-28897	IN	denotes	of
T7206	28898-28901	DT	denotes	the
T7207	28917-28923	NN	denotes	domain
T7208	28902-28911	VBN	denotes	conserved
T7209	28912-28916	NN	denotes	TACC
T7210	28923-28924	.	denotes	.
T7211	28924-29223	sentence	denotes	Using an in silico protein-protein interaction model based upon known mitotic spindle and centrosomal components, we have previously predicted a number of additional interactions that could be conserved between a functional TACC homologue in yeast, spc-72, and one or more human TACC proteins [21].
T7212	28925-28930	VBG	denotes	Using
T7213	29058-29067	VBN	denotes	predicted
T7214	28931-28933	DT	denotes	an
T7215	28972-28977	NN	denotes	model
T7216	28934-28936	FW	denotes	in
T7217	28937-28943	FW	denotes	silico
T7218	28944-28951	NN	denotes	protein
T7219	28952-28959	NN	denotes	protein
T7220	28951-28952	HYPH	denotes	-
T7221	28960-28971	NN	denotes	interaction
T7222	28978-28983	VBN	denotes	based
T7223	28984-28988	IN	denotes	upon
T7224	28989-28994	JJ	denotes	known
T7225	29027-29037	NNS	denotes	components
T7226	28995-29002	JJ	denotes	mitotic
T7227	29003-29010	NN	denotes	spindle
T7228	29011-29014	CC	denotes	and
T7229	29015-29026	JJ	denotes	centrosomal
T7230	29037-29039	,	denotes	,
T7231	29039-29041	PRP	denotes	we
T7232	29042-29046	VBP	denotes	have
T7233	29047-29057	RB	denotes	previously
T7234	29068-29069	DT	denotes	a
T7235	29070-29076	NN	denotes	number
T7236	29077-29079	IN	denotes	of
T7237	29080-29090	JJ	denotes	additional
T7238	29091-29103	NNS	denotes	interactions
T7239	29104-29108	WDT	denotes	that
T7240	29118-29127	VBN	denotes	conserved
T7241	29109-29114	MD	denotes	could
T7242	29115-29117	VB	denotes	be
T7243	29128-29135	IN	denotes	between
T7244	29136-29137	DT	denotes	a
T7245	29154-29163	NN	denotes	homologue
T7246	29138-29148	JJ	denotes	functional
T7247	29149-29153	NN	denotes	TACC
T7248	29164-29166	IN	denotes	in
T7249	29167-29172	NN	denotes	yeast
T7250	29172-29174	,	denotes	,
T7251	29174-29177	NN	denotes	spc
T7252	29177-29178	HYPH	denotes	-
T7253	29178-29180	CD	denotes	72
T7254	29180-29182	,	denotes	,
T7255	29182-29185	CC	denotes	and
T7256	29186-29189	CD	denotes	one
T7257	29209-29217	NN	denotes	proteins
T7258	29190-29192	CC	denotes	or
T7259	29193-29197	JJR	denotes	more
T7260	29198-29203	JJ	denotes	human
T7261	29204-29208	NN	denotes	TACC
T7262	29218-29219	-LRB-	denotes	[
T7263	29219-29221	CD	denotes	21
T7264	29221-29222	-RRB-	denotes	]
T7265	29222-29223	.	denotes	.
T7266	29223-29442	sentence	denotes	Thus, it is known that all the TACC proteins examined to date interact, via the TACC domain, with the microtubule/centrosomal proteins of the stu2/msps/ch-TOG family [5,6,22-24], and with the Aurora kinases [20,21,25].
T7267	29224-29228	RB	denotes	Thus
T7268	29236-29241	VBN	denotes	known
T7269	29228-29230	,	denotes	,
T7270	29230-29232	PRP	denotes	it
T7271	29233-29235	VBZ	denotes	is
T7272	29242-29246	IN	denotes	that
T7273	29286-29294	VBP	denotes	interact
T7274	29247-29250	PDT	denotes	all
T7275	29260-29268	NN	denotes	proteins
T7276	29251-29254	DT	denotes	the
T7277	29255-29259	NN	denotes	TACC
T7278	29269-29277	VBN	denotes	examined
T7279	29278-29280	IN	denotes	to
T7280	29281-29285	NN	denotes	date
T7281	29294-29296	,	denotes	,
T7282	29296-29299	IN	denotes	via
T7283	29300-29303	DT	denotes	the
T7284	29309-29315	NN	denotes	domain
T7285	29304-29308	NN	denotes	TACC
T7286	29315-29317	,	denotes	,
T7287	29317-29321	IN	denotes	with
T7288	29322-29325	DT	denotes	the
T7289	29350-29358	NN	denotes	proteins
T7290	29326-29337	NN	denotes	microtubule
T7291	29338-29349	JJ	denotes	centrosomal
T7292	29337-29338	HYPH	denotes	/
T7293	29359-29361	IN	denotes	of
T7294	29362-29365	DT	denotes	the
T7295	29383-29389	NN	denotes	family
T7296	29366-29370	NN	denotes	stu2
T7297	29370-29371	HYPH	denotes	/
T7298	29371-29375	NN	denotes	msps
T7299	29375-29376	HYPH	denotes	/
T7300	29376-29378	NN	denotes	ch
T7301	29379-29382	NN	denotes	TOG
T7302	29378-29379	HYPH	denotes	-
T7303	29390-29391	-LRB-	denotes	[
T7304	29391-29392	CD	denotes	5
T7305	29392-29393	,	denotes	,
T7306	29393-29394	CD	denotes	6
T7307	29394-29395	,	denotes	,
T7308	29395-29397	CD	denotes	22
T7309	29397-29398	SYM	denotes	-
T7310	29398-29400	CD	denotes	24
T7311	29400-29401	-RRB-	denotes	]
T7312	29401-29403	,	denotes	,
T7313	29403-29406	CC	denotes	and
T7314	29407-29411	IN	denotes	with
T7315	29412-29415	DT	denotes	the
T7316	29423-29430	NNS	denotes	kinases
T7317	29416-29422	NN	denotes	Aurora
T7318	29431-29432	-LRB-	denotes	[
T7319	29438-29440	CD	denotes	25
T7320	29432-29434	CD	denotes	20
T7321	29434-29435	,	denotes	,
T7322	29435-29437	CD	denotes	21
T7323	29437-29438	,	denotes	,
T7324	29440-29441	-RRB-	denotes	]
T7325	29441-29442	.	denotes	.
T7326	29442-29574	sentence	denotes	These interactions are required for the accumulation of the D-TACC, spc72, ceTAC1 and TACC3 proteins to the centrosome [5,6,22-24].
T7327	29443-29448	DT	denotes	These
T7328	29449-29461	NNS	denotes	interactions
T7329	29466-29474	VBN	denotes	required
T7330	29462-29465	VBP	denotes	are
T7331	29475-29478	IN	denotes	for
T7332	29479-29482	DT	denotes	the
T7333	29483-29495	NN	denotes	accumulation
T7334	29496-29498	IN	denotes	of
T7335	29499-29502	DT	denotes	the
T7336	29535-29543	NN	denotes	proteins
T7337	29503-29504	NN	denotes	D
T7338	29505-29509	NN	denotes	TACC
T7339	29504-29505	HYPH	denotes	-
T7340	29509-29511	,	denotes	,
T7341	29511-29516	NN	denotes	spc72
T7342	29516-29518	,	denotes	,
T7343	29518-29524	NN	denotes	ceTAC1
T7344	29525-29528	CC	denotes	and
T7345	29529-29534	NN	denotes	TACC3
T7346	29544-29546	IN	denotes	to
T7347	29547-29550	DT	denotes	the
T7348	29551-29561	NN	denotes	centrosome
T7349	29562-29563	-LRB-	denotes	[
T7350	29563-29564	CD	denotes	5
T7351	29564-29565	,	denotes	,
T7352	29565-29566	CD	denotes	6
T7353	29566-29567	,	denotes	,
T7354	29567-29569	CD	denotes	22
T7355	29569-29570	SYM	denotes	-
T7356	29570-29572	CD	denotes	24
T7357	29572-29573	-RRB-	denotes	]
T7358	29573-29574	.	denotes	.
T7359	29574-29724	sentence	denotes	Hence, this functional interaction with the centrosome and mitotic spindle is likely to represent the ancient, conserved function of the TACC family.
T7360	29575-29580	RB	denotes	Hence
T7361	29650-29652	VBZ	denotes	is
T7362	29580-29582	,	denotes	,
T7363	29582-29586	DT	denotes	this
T7364	29598-29609	NN	denotes	interaction
T7365	29587-29597	JJ	denotes	functional
T7366	29610-29614	IN	denotes	with
T7367	29615-29618	DT	denotes	the
T7368	29619-29629	NN	denotes	centrosome
T7369	29630-29633	CC	denotes	and
T7370	29634-29641	JJ	denotes	mitotic
T7371	29642-29649	NN	denotes	spindle
T7372	29653-29659	JJ	denotes	likely
T7373	29660-29662	TO	denotes	to
T7374	29663-29672	VB	denotes	represent
T7375	29673-29676	DT	denotes	the
T7376	29696-29704	NN	denotes	function
T7377	29677-29684	JJ	denotes	ancient
T7378	29684-29686	,	denotes	,
T7379	29686-29695	VBN	denotes	conserved
T7380	29705-29707	IN	denotes	of
T7381	29708-29711	DT	denotes	the
T7382	29717-29723	NN	denotes	family
T7383	29712-29716	NN	denotes	TACC
T7384	29723-29724	.	denotes	.
T7385	29724-29843	sentence	denotes	However, it is apparent that the human TACC proteins also differ in their ability to interact with the Aurora kinases.
T7386	29725-29732	RB	denotes	However
T7387	29737-29739	VBZ	denotes	is
T7388	29732-29734	,	denotes	,
T7389	29734-29736	PRP	denotes	it
T7390	29740-29748	JJ	denotes	apparent
T7391	29749-29753	IN	denotes	that
T7392	29783-29789	VBP	denotes	differ
T7393	29754-29757	DT	denotes	the
T7394	29769-29777	NN	denotes	proteins
T7395	29758-29763	JJ	denotes	human
T7396	29764-29768	NN	denotes	TACC
T7397	29778-29782	RB	denotes	also
T7398	29790-29792	IN	denotes	in
T7399	29793-29798	PRP$	denotes	their
T7400	29799-29806	NN	denotes	ability
T7401	29807-29809	TO	denotes	to
T7402	29810-29818	VB	denotes	interact
T7403	29819-29823	IN	denotes	with
T7404	29824-29827	DT	denotes	the
T7405	29835-29842	NNS	denotes	kinases
T7406	29828-29834	NN	denotes	Aurora
T7407	29842-29843	.	denotes	.
T7408	29843-30105	sentence	denotes	For instance, TACC1 and TACC3 interact with Aurora A kinase, whereas TACC2 interacts with Aurora C kinase [21], suggesting a degree of functional specialization in the derivatives of the ancestral chordate TACC, after the radiation of the vertebrate TACC genes.
T7409	29844-29847	IN	denotes	For
T7410	29874-29882	VBP	denotes	interact
T7411	29848-29856	NN	denotes	instance
T7412	29856-29858	,	denotes	,
T7413	29858-29863	NN	denotes	TACC1
T7414	29864-29867	CC	denotes	and
T7415	29868-29873	NN	denotes	TACC3
T7416	29883-29887	IN	denotes	with
T7417	29888-29894	NN	denotes	Aurora
T7418	29895-29896	NN	denotes	A
T7419	29897-29903	NN	denotes	kinase
T7420	29903-29905	,	denotes	,
T7421	29905-29912	IN	denotes	whereas
T7422	29919-29928	VBZ	denotes	interacts
T7423	29913-29918	NN	denotes	TACC2
T7424	29929-29933	IN	denotes	with
T7425	29934-29940	NN	denotes	Aurora
T7426	29941-29942	NN	denotes	C
T7427	29943-29949	NN	denotes	kinase
T7428	29950-29951	-LRB-	denotes	[
T7429	29951-29953	CD	denotes	21
T7430	29953-29954	-RRB-	denotes	]
T7431	29954-29956	,	denotes	,
T7432	29956-29966	VBG	denotes	suggesting
T7433	29967-29968	DT	denotes	a
T7434	29969-29975	NN	denotes	degree
T7435	29976-29978	IN	denotes	of
T7436	29979-29989	JJ	denotes	functional
T7437	29990-30004	NN	denotes	specialization
T7438	30005-30007	IN	denotes	in
T7439	30008-30011	DT	denotes	the
T7440	30012-30023	NNS	denotes	derivatives
T7441	30024-30026	IN	denotes	of
T7442	30027-30030	DT	denotes	the
T7443	30050-30054	NN	denotes	TACC
T7444	30031-30040	JJ	denotes	ancestral
T7445	30041-30049	NN	denotes	chordate
T7446	30054-30056	,	denotes	,
T7447	30056-30061	IN	denotes	after
T7448	30062-30065	DT	denotes	the
T7449	30066-30075	NN	denotes	radiation
T7450	30076-30078	IN	denotes	of
T7451	30079-30082	DT	denotes	the
T7452	30099-30104	NNS	denotes	genes
T7453	30083-30093	NN	denotes	vertebrate
T7454	30094-30098	NN	denotes	TACC
T7455	30104-30105	.	denotes	.
T7456	30105-30307	sentence	denotes	The localization of the vertebrate TACC proteins in the interphase nucleus [15,26,27] suggests that they have additional functions outside their ancient role in the centrosome and microtubule dynamics.
T7457	30106-30109	DT	denotes	The
T7458	30110-30122	NN	denotes	localization
T7459	30192-30200	VBZ	denotes	suggests
T7460	30123-30125	IN	denotes	of
T7461	30126-30129	DT	denotes	the
T7462	30146-30154	NN	denotes	proteins
T7463	30130-30140	NN	denotes	vertebrate
T7464	30141-30145	NN	denotes	TACC
T7465	30155-30157	IN	denotes	in
T7466	30158-30161	DT	denotes	the
T7467	30173-30180	NN	denotes	nucleus
T7468	30162-30172	NN	denotes	interphase
T7469	30181-30182	-LRB-	denotes	[
T7470	30188-30190	CD	denotes	27
T7471	30182-30184	CD	denotes	15
T7472	30184-30185	,	denotes	,
T7473	30185-30187	CD	denotes	26
T7474	30187-30188	,	denotes	,
T7475	30190-30191	-RRB-	denotes	]
T7476	30201-30205	IN	denotes	that
T7477	30211-30215	VBP	denotes	have
T7478	30206-30210	PRP	denotes	they
T7479	30216-30226	JJ	denotes	additional
T7480	30227-30236	NNS	denotes	functions
T7481	30237-30244	IN	denotes	outside
T7482	30245-30250	PRP$	denotes	their
T7483	30259-30263	NN	denotes	role
T7484	30251-30258	JJ	denotes	ancient
T7485	30264-30266	IN	denotes	in
T7486	30267-30270	DT	denotes	the
T7487	30298-30306	NNS	denotes	dynamics
T7488	30271-30281	NN	denotes	centrosome
T7489	30282-30285	CC	denotes	and
T7490	30286-30297	NN	denotes	microtubule
T7491	30306-30307	.	denotes	.
T7492	30307-30478	sentence	denotes	Thus, it seems likely that TACC family members in protostomes and deuterostomes have integrated new unique functions as the evolving TACC genes acquired additional exons.
T7493	30308-30312	RB	denotes	Thus
T7494	30317-30322	VBZ	denotes	seems
T7495	30312-30314	,	denotes	,
T7496	30314-30316	PRP	denotes	it
T7497	30323-30329	JJ	denotes	likely
T7498	30330-30334	IN	denotes	that
T7499	30393-30403	VBN	denotes	integrated
T7500	30335-30339	NN	denotes	TACC
T7501	30347-30354	NNS	denotes	members
T7502	30340-30346	NN	denotes	family
T7503	30355-30357	IN	denotes	in
T7504	30358-30369	NNS	denotes	protostomes
T7505	30370-30373	CC	denotes	and
T7506	30374-30387	NNS	denotes	deuterostomes
T7507	30388-30392	VBP	denotes	have
T7508	30404-30407	JJ	denotes	new
T7509	30415-30424	NNS	denotes	functions
T7510	30408-30414	JJ	denotes	unique
T7511	30425-30427	IN	denotes	as
T7512	30452-30460	VBD	denotes	acquired
T7513	30428-30431	DT	denotes	the
T7514	30446-30451	NNS	denotes	genes
T7515	30432-30440	VBG	denotes	evolving
T7516	30441-30445	NN	denotes	TACC
T7517	30461-30471	JJ	denotes	additional
T7518	30472-30477	NNS	denotes	exons
T7519	30477-30478	.	denotes	.
T7520	30478-30634	sentence	denotes	The results of the pilot large-scale proteomic analysis in C. elegans and D. melanogaster provide further suggestive evidence to this functional evolution.
T7521	30479-30482	DT	denotes	The
T7522	30483-30490	NNS	denotes	results
T7523	30569-30576	VBP	denotes	provide
T7524	30491-30493	IN	denotes	of
T7525	30494-30497	DT	denotes	the
T7526	30526-30534	NN	denotes	analysis
T7527	30498-30503	NN	denotes	pilot
T7528	30504-30509	JJ	denotes	large
T7529	30510-30515	NN	denotes	scale
T7530	30509-30510	HYPH	denotes	-
T7531	30516-30525	JJ	denotes	proteomic
T7532	30535-30537	IN	denotes	in
T7533	30538-30540	NNP	denotes	C.
T7534	30541-30548	NNP	denotes	elegans
T7535	30549-30552	CC	denotes	and
T7536	30553-30555	NNP	denotes	D.
T7537	30556-30568	NNP	denotes	melanogaster
T7538	30577-30584	JJ	denotes	further
T7539	30596-30604	NN	denotes	evidence
T7540	30585-30595	JJ	denotes	suggestive
T7541	30605-30607	IN	denotes	to
T7542	30608-30612	DT	denotes	this
T7543	30624-30633	NN	denotes	evolution
T7544	30613-30623	JJ	denotes	functional
T7545	30633-30634	.	denotes	.
T7546	30634-30740	sentence	denotes	Yeast two hybrid analysis indicates that ceTAC directly binds to C. elegans lin15A, lin36 and lin37 [28].
T7547	30635-30640	NN	denotes	Yeast
T7548	30652-30660	NN	denotes	analysis
T7549	30641-30644	CD	denotes	two
T7550	30645-30651	NN	denotes	hybrid
T7551	30661-30670	VBZ	denotes	indicates
T7552	30671-30675	IN	denotes	that
T7553	30691-30696	VBZ	denotes	binds
T7554	30676-30681	NN	denotes	ceTAC
T7555	30682-30690	RB	denotes	directly
T7556	30697-30699	IN	denotes	to
T7557	30700-30702	NNP	denotes	C.
T7558	30711-30717	NN	denotes	lin15A
T7559	30703-30710	NNP	denotes	elegans
T7560	30717-30719	,	denotes	,
T7561	30719-30724	NN	denotes	lin36
T7562	30725-30728	CC	denotes	and
T7563	30729-30734	NN	denotes	lin37
T7564	30735-30736	-LRB-	denotes	[
T7565	30736-30738	CD	denotes	28
T7566	30738-30739	-RRB-	denotes	]
T7567	30739-30740	.	denotes	.
T7568	30740-31123	sentence	denotes	These proteins bridge ceTAC to other elements of the cytoskeleton and microtubule network, as well as to components of the ribosome, the histone deacetylase chromatin remodeling machinery such as egr-1 and lin-53 (the C. elegans homologues of the human MTA-1 and RbAP48), and to transcription factors such as the PAL1 homeobox and the nuclear hormone receptor nhr-86 [28] (Fig. 6A).
T7569	30741-30746	DT	denotes	These
T7570	30747-30755	NN	denotes	proteins
T7571	30756-30762	VBP	denotes	bridge
T7572	30763-30768	NN	denotes	ceTAC
T7573	30769-30771	IN	denotes	to
T7574	30772-30777	JJ	denotes	other
T7575	30778-30786	NNS	denotes	elements
T7576	30787-30789	IN	denotes	of
T7577	30790-30793	DT	denotes	the
T7578	30823-30830	NN	denotes	network
T7579	30794-30806	NN	denotes	cytoskeleton
T7580	30807-30810	CC	denotes	and
T7581	30811-30822	NN	denotes	microtubule
T7582	30830-30832	,	denotes	,
T7583	30832-30834	RB	denotes	as
T7584	30840-30842	IN	denotes	as
T7585	30835-30839	RB	denotes	well
T7586	30843-30845	IN	denotes	to
T7587	30846-30856	NNS	denotes	components
T7588	30857-30859	IN	denotes	of
T7589	30860-30863	DT	denotes	the
T7590	30864-30872	NN	denotes	ribosome
T7591	30872-30874	,	denotes	,
T7592	30874-30877	DT	denotes	the
T7593	30919-30928	NN	denotes	machinery
T7594	30878-30885	NN	denotes	histone
T7595	30886-30897	NN	denotes	deacetylase
T7596	30898-30907	NN	denotes	chromatin
T7597	30908-30918	VBG	denotes	remodeling
T7598	30929-30933	JJ	denotes	such
T7599	30934-30936	IN	denotes	as
T7600	30937-30940	NN	denotes	egr
T7601	30940-30941	HYPH	denotes	-
T7602	30941-30942	CD	denotes	1
T7603	30943-30946	CC	denotes	and
T7604	30947-30950	NN	denotes	lin
T7605	30950-30951	HYPH	denotes	-
T7606	30951-30953	CD	denotes	53
T7607	30954-30955	-LRB-	denotes	(
T7608	30955-30958	DT	denotes	the
T7609	30970-30980	NNS	denotes	homologues
T7610	30959-30961	NNP	denotes	C.
T7611	30962-30969	NNP	denotes	elegans
T7612	30981-30983	IN	denotes	of
T7613	30984-30987	DT	denotes	the
T7614	30994-30997	NN	denotes	MTA
T7615	30988-30993	JJ	denotes	human
T7616	30997-30998	HYPH	denotes	-
T7617	30998-30999	CD	denotes	1
T7618	31000-31003	CC	denotes	and
T7619	31004-31010	NN	denotes	RbAP48
T7620	31010-31011	-RRB-	denotes	)
T7621	31011-31013	,	denotes	,
T7622	31013-31016	CC	denotes	and
T7623	31017-31019	IN	denotes	to
T7624	31020-31033	NN	denotes	transcription
T7625	31034-31041	NNS	denotes	factors
T7626	31042-31046	JJ	denotes	such
T7627	31047-31049	IN	denotes	as
T7628	31050-31053	DT	denotes	the
T7629	31059-31067	NN	denotes	homeobox
T7630	31054-31058	NN	denotes	PAL1
T7631	31068-31071	CC	denotes	and
T7632	31072-31075	DT	denotes	the
T7633	31092-31100	NN	denotes	receptor
T7634	31076-31083	JJ	denotes	nuclear
T7635	31084-31091	NN	denotes	hormone
T7636	31101-31104	NN	denotes	nhr
T7637	31104-31105	HYPH	denotes	-
T7638	31105-31107	CD	denotes	86
T7639	31108-31109	-LRB-	denotes	[
T7640	31109-31111	CD	denotes	28
T7641	31111-31112	-RRB-	denotes	]
T7642	31113-31114	-LRB-	denotes	(
T7643	31114-31118	NN	denotes	Fig.
T7644	31119-31121	CD	denotes	6A
T7645	31121-31122	-RRB-	denotes	)
T7646	31122-31123	.	denotes	.
T7647	31123-31384	sentence	denotes	Similarly, large scale proteomics [29] has shown that Drosophila TACC interacts with two proteins, the RNA binding protein TBPH and CG14540 (Fig. 6B), and thus indirectly with the Drosophila SWI/SNF chromatin remodeling complex and DNA damage repair machinery.
T7648	31124-31133	RB	denotes	Similarly
T7649	31167-31172	VBN	denotes	shown
T7650	31133-31135	,	denotes	,
T7651	31135-31140	JJ	denotes	large
T7652	31141-31146	NN	denotes	scale
T7653	31147-31157	NNS	denotes	proteomics
T7654	31158-31159	-LRB-	denotes	[
T7655	31159-31161	CD	denotes	29
T7656	31161-31162	-RRB-	denotes	]
T7657	31163-31166	VBZ	denotes	has
T7658	31173-31177	IN	denotes	that
T7659	31194-31203	VBZ	denotes	interacts
T7660	31178-31188	NNP	denotes	Drosophila
T7661	31189-31193	NN	denotes	TACC
T7662	31204-31208	IN	denotes	with
T7663	31209-31212	CD	denotes	two
T7664	31213-31221	NN	denotes	proteins
T7665	31221-31223	,	denotes	,
T7666	31223-31226	DT	denotes	the
T7667	31239-31246	NN	denotes	protein
T7668	31227-31230	NN	denotes	RNA
T7669	31231-31238	NN	denotes	binding
T7670	31247-31251	NN	denotes	TBPH
T7671	31252-31255	CC	denotes	and
T7672	31256-31263	NN	denotes	CG14540
T7680	31295-31299	IN	denotes	with
T7681	31284-31294	RB	denotes	indirectly
T7682	31300-31303	DT	denotes	the
T7683	31344-31351	NN	denotes	complex
T7684	31304-31314	NNP	denotes	Drosophila
T7685	31315-31318	NN	denotes	SWI
T7686	31319-31322	NN	denotes	SNF
T7687	31318-31319	HYPH	denotes	/
T7688	31323-31332	NN	denotes	chromatin
T7689	31333-31343	NN	denotes	remodeling
T7690	31352-31355	CC	denotes	and
T7691	31356-31359	NN	denotes	DNA
T7692	31360-31366	NN	denotes	damage
T7693	31367-31373	NN	denotes	repair
T7694	31374-31383	NN	denotes	machinery
T7695	31383-31384	.	denotes	.
T7696	31384-31539	sentence	denotes	Significantly, the ceTAC protein has also recently been implicated in DNA repair through its direct interaction with the C. elegans BARD1 orthologue [30].
T7697	31385-31398	RB	denotes	Significantly
T7698	31441-31451	VBN	denotes	implicated
T7699	31398-31400	,	denotes	,
T7700	31400-31403	DT	denotes	the
T7701	31410-31417	NN	denotes	protein
T7702	31404-31409	NN	denotes	ceTAC
T7703	31418-31421	VBZ	denotes	has
T7704	31422-31426	RB	denotes	also
T7705	31427-31435	RB	denotes	recently
T7706	31436-31440	VBN	denotes	been
T7707	31452-31454	IN	denotes	in
T7708	31455-31458	NN	denotes	DNA
T7709	31459-31465	NN	denotes	repair
T7710	31466-31473	IN	denotes	through
T7711	31474-31477	PRP$	denotes	its
T7712	31485-31496	NN	denotes	interaction
T7713	31478-31484	JJ	denotes	direct
T7714	31497-31501	IN	denotes	with
T7715	31502-31505	DT	denotes	the
T7716	31523-31533	NN	denotes	orthologue
T7717	31506-31508	NNP	denotes	C.
T7718	31509-31516	NNP	denotes	elegans
T7719	31517-31522	NN	denotes	BARD1
T7720	31534-31535	-LRB-	denotes	[
T7721	31535-31537	CD	denotes	30
T7722	31537-31538	-RRB-	denotes	]
T7723	31538-31539	.	denotes	.
T7724	31539-31795	sentence	denotes	It should be noted that a number of interactions with the TACC proteins from these organisms have probably been missed by these large scale methods, including the well documented direct interactions with the aurora kinases and the stu2/msps/ch-TOG family.
T7725	31540-31542	PRP	denotes	It
T7726	31553-31558	VBN	denotes	noted
T7727	31543-31549	MD	denotes	should
T7728	31550-31552	VB	denotes	be
T7729	31559-31563	IN	denotes	that
T7730	31652-31658	VBN	denotes	missed
T7731	31564-31565	DT	denotes	a
T7732	31566-31572	NN	denotes	number
T7733	31573-31575	IN	denotes	of
T7734	31576-31588	NNS	denotes	interactions
T7735	31589-31593	IN	denotes	with
T7736	31594-31597	DT	denotes	the
T7737	31603-31611	NN	denotes	proteins
T7738	31598-31602	NN	denotes	TACC
T7739	31612-31616	IN	denotes	from
T7740	31617-31622	DT	denotes	these
T7741	31623-31632	NNS	denotes	organisms
T7742	31633-31637	VBP	denotes	have
T7743	31638-31646	RB	denotes	probably
T7744	31647-31651	VBN	denotes	been
T7745	31659-31661	IN	denotes	by
T7746	31662-31667	DT	denotes	these
T7747	31680-31687	NNS	denotes	methods
T7748	31668-31673	JJ	denotes	large
T7749	31674-31679	NN	denotes	scale
T7750	31687-31689	,	denotes	,
T7751	31689-31698	VBG	denotes	including
T7752	31699-31702	DT	denotes	the
T7753	31726-31738	NNS	denotes	interactions
T7754	31703-31707	RB	denotes	well
T7755	31708-31718	VBN	denotes	documented
T7756	31719-31725	JJ	denotes	direct
T7757	31739-31743	IN	denotes	with
T7758	31744-31747	DT	denotes	the
T7759	31755-31762	NNS	denotes	kinases
T7760	31748-31754	NN	denotes	aurora
T7761	31763-31766	CC	denotes	and
T7762	31767-31770	DT	denotes	the
T7763	31788-31794	NN	denotes	family
T7764	31771-31775	NN	denotes	stu2
T7765	31775-31776	HYPH	denotes	/
T7766	31776-31780	NN	denotes	msps
T7767	31780-31781	HYPH	denotes	/
T7768	31781-31783	NN	denotes	ch
T7769	31784-31787	NN	denotes	TOG
T7770	31783-31784	HYPH	denotes	-
T7771	31794-31795	.	denotes	.
T7780	32949-32952	DT	denotes	the
T7781	32958-32964	NN	denotes	domain
T7782	32953-32957	NN	denotes	TACC
T7783	32964-32966	,	denotes	,
T7784	32966-32968	PRP	denotes	we
T7785	32969-32974	MD	denotes	would
T7786	32983-32987	IN	denotes	that
T7787	33072-33080	VBN	denotes	observed
T7788	32988-32992	DT	denotes	some
T7789	32993-32995	IN	denotes	of
T7790	32996-32999	DT	denotes	the
T7791	33011-33023	NNS	denotes	interactions
T7792	33000-33010	JJ	denotes	functional
T7793	33024-33028	VBN	denotes	seen
T7794	33029-33031	IN	denotes	in
T7795	33032-33034	NNP	denotes	C.
T7796	33035-33042	NNP	denotes	elegans
T7797	33043-33046	CC	denotes	and
T7798	33047-33049	NNP	denotes	D.
T7799	33050-33062	NNP	denotes	melanogaster
T7800	33063-33068	MD	denotes	would
T7801	33069-33071	VB	denotes	be
T7802	33081-33083	IN	denotes	in
T7803	33084-33090	JJR	denotes	higher
T7804	33091-33098	NNS	denotes	animals
T7805	33098-33099	.	denotes	.
T7806	33099-33241	sentence	denotes	Phylogenetic profiling from these interaction maps suggests two similar sets of predicted interactions for vertebrate TACCs (Fig. 6C and 6D).
T7807	33100-33112	JJ	denotes	Phylogenetic
T7808	33113-33122	NN	denotes	profiling
T7809	33151-33159	VBZ	denotes	suggests
T7810	33123-33127	IN	denotes	from
T7811	33128-33133	DT	denotes	these
T7812	33146-33150	NNS	denotes	maps
T7813	33134-33145	NN	denotes	interaction
T7814	33160-33163	CD	denotes	two
T7815	33172-33176	NNS	denotes	sets
T7816	33164-33171	JJ	denotes	similar
T7817	33177-33179	IN	denotes	of
T7818	33180-33189	VBN	denotes	predicted
T7819	33190-33202	NNS	denotes	interactions
T7820	33203-33206	IN	denotes	for
T7821	33207-33217	NN	denotes	vertebrate
T7822	33218-33223	NNS	denotes	TACCs
T7823	33224-33225	-LRB-	denotes	(
T7824	33230-33232	CD	denotes	6C
T7825	33225-33229	NN	denotes	Fig.
T7826	33233-33236	CC	denotes	and
T7827	33237-33239	CD	denotes	6D
T7828	33239-33240	-RRB-	denotes	)
T7829	33240-33241	.	denotes	.
T7830	33241-33578	sentence	denotes	Strikingly, however, the C. elegans specific proteins lin15A, lin36 and lin37 do not have readily discernible homologues in vertebrates or Drosophila, although the presence of a zinc finger domain in lin36 may suggest that this protein is involved directly in transcription or perform an adaptor role similar to LIM containing proteins.
T7831	33242-33252	RB	denotes	Strikingly
T7832	33327-33331	VB	denotes	have
T7833	33252-33254	,	denotes	,
T7834	33254-33261	RB	denotes	however
T7835	33261-33263	,	denotes	,
T7836	33263-33266	DT	denotes	the
T7837	33287-33295	NN	denotes	proteins
T7838	33267-33269	NNP	denotes	C.
T7839	33270-33277	NNP	denotes	elegans
T7840	33278-33286	JJ	denotes	specific
T7841	33296-33302	NN	denotes	lin15A
T7842	33302-33304	,	denotes	,
T7843	33304-33309	NN	denotes	lin36
T7844	33310-33313	CC	denotes	and
T7845	33314-33319	NN	denotes	lin37
T7846	33320-33322	VBP	denotes	do
T7847	33323-33326	RB	denotes	not
T7848	33332-33339	RB	denotes	readily
T7849	33340-33351	JJ	denotes	discernible
T7850	33352-33362	NNS	denotes	homologues
T7851	33363-33365	IN	denotes	in
T7852	33366-33377	NNS	denotes	vertebrates
T7853	33378-33380	CC	denotes	or
T7854	33381-33391	NNP	denotes	Drosophila
T7855	33391-33393	,	denotes	,
T7856	33393-33401	IN	denotes	although
T7857	33452-33459	VB	denotes	suggest
T7858	33402-33405	DT	denotes	the
T7859	33406-33414	NN	denotes	presence
T7860	33415-33417	IN	denotes	of
T7861	33418-33419	DT	denotes	a
T7862	33432-33438	NN	denotes	domain
T7863	33420-33424	NN	denotes	zinc
T7864	33425-33431	NN	denotes	finger
T7865	33439-33441	IN	denotes	in
T7866	33442-33447	NN	denotes	lin36
T7867	33448-33451	MD	denotes	may
T7868	33460-33464	IN	denotes	that
T7869	33481-33489	VBN	denotes	involved
T7870	33465-33469	DT	denotes	this
T7871	33470-33477	NN	denotes	protein
T7872	33478-33480	VBZ	denotes	is
T7873	33490-33498	RB	denotes	directly
T7874	33499-33501	IN	denotes	in
T7875	33502-33515	NN	denotes	transcription
T7876	33516-33518	CC	denotes	or
T7877	33519-33526	VB	denotes	perform
T7878	33527-33529	DT	denotes	an
T7879	33538-33542	NN	denotes	role
T7880	33530-33537	NN	denotes	adaptor
T7881	33543-33550	JJ	denotes	similar
T7882	33551-33553	IN	denotes	to
T7883	33554-33557	NN	denotes	LIM
T7884	33558-33568	VBG	denotes	containing
T7885	33569-33577	NN	denotes	proteins
T7886	33577-33578	.	denotes	.
T7887	33578-33714	sentence	denotes	For the DTACC interacting proteins, TBPH corresponds to TDP43, a protein implicated in transcriptional regulation and splicing [31,32].
T7888	33579-33582	IN	denotes	For
T7889	33620-33631	VBZ	denotes	corresponds
T7890	33583-33586	DT	denotes	the
T7891	33605-33613	NN	denotes	proteins
T7892	33587-33592	NN	denotes	DTACC
T7893	33593-33604	VBG	denotes	interacting
T7894	33613-33615	,	denotes	,
T7895	33615-33619	NN	denotes	TBPH
T7896	33632-33634	IN	denotes	to
T7897	33635-33640	NN	denotes	TDP43
T7898	33640-33642	,	denotes	,
T7899	33642-33643	DT	denotes	a
T7900	33644-33651	NN	denotes	protein
T7901	33652-33662	VBN	denotes	implicated
T7902	33663-33665	IN	denotes	in
T7903	33666-33681	JJ	denotes	transcriptional
T7904	33682-33692	NN	denotes	regulation
T7905	33693-33696	CC	denotes	and
T7906	33697-33705	NN	denotes	splicing
T7907	33706-33707	-LRB-	denotes	[
T7908	33710-33712	CD	denotes	32
T7909	33707-33709	CD	denotes	31
T7910	33709-33710	,	denotes	,
T7911	33712-33713	-RRB-	denotes	]
T7912	33713-33714	.	denotes	.
T7913	33714-33932	sentence	denotes	However, the assignment of the human homologue of CG14540 is less clear, with the closest matches in the human databases corresponding to glutamine rich transcription factors such as CREB and the G-box binding factor.
T7914	33715-33722	RB	denotes	However
T7915	33773-33775	VBZ	denotes	is
T7916	33722-33724	,	denotes	,
T7917	33724-33727	DT	denotes	the
T7918	33728-33738	NN	denotes	assignment
T7919	33739-33741	IN	denotes	of
T7920	33742-33745	DT	denotes	the
T7921	33752-33761	NN	denotes	homologue
T7922	33746-33751	JJ	denotes	human
T7923	33762-33764	IN	denotes	of
T7924	33765-33772	NN	denotes	CG14540
T7925	33776-33780	RBR	denotes	less
T7926	33781-33786	JJ	denotes	clear
T7927	33786-33788	,	denotes	,
T7928	33788-33792	IN	denotes	with
T7929	33793-33796	DT	denotes	the
T7930	33805-33812	NNS	denotes	matches
T7931	33797-33804	JJS	denotes	closest
T7932	33836-33849	VBG	denotes	corresponding
T7933	33813-33815	IN	denotes	in
T7934	33816-33819	DT	denotes	the
T7935	33826-33835	NNS	denotes	databases
T7936	33820-33825	JJ	denotes	human
T7937	33850-33852	IN	denotes	to
T7938	33853-33862	NN	denotes	glutamine
T7939	33863-33867	JJ	denotes	rich
T7940	33882-33889	NNS	denotes	factors
T7941	33868-33881	NN	denotes	transcription
T7942	33890-33894	JJ	denotes	such
T7943	33895-33897	IN	denotes	as
T7944	33898-33902	NN	denotes	CREB
T7945	33903-33906	CC	denotes	and
T7946	33907-33910	DT	denotes	the
T7947	33925-33931	NN	denotes	factor
T7948	33911-33912	NN	denotes	G
T7949	33913-33916	NN	denotes	box
T7950	33912-33913	HYPH	denotes	-
T7951	33917-33924	NN	denotes	binding
T7952	33931-33932	.	denotes	.
T8332	33934-33944	NN	denotes	Comparison
T8333	33945-33947	IN	denotes	of
T8334	33948-33955	VBN	denotes	modeled
T8335	33956-33960	IN	denotes	with
T8336	33961-33975	RB	denotes	experimentally
T8337	33976-33983	VBN	denotes	defined
T8338	33984-33996	NNS	denotes	interactions
T8339	33997-33999	IN	denotes	of
T8340	34000-34003	DT	denotes	the
T8341	34020-34028	NN	denotes	proteins
T8342	34004-34014	NN	denotes	vertebrate
T8343	34015-34019	NN	denotes	TACC
T8344	34028-34156	sentence	denotes	The interaction data for the vertebrate TACCs is relatively limited; however, interaction networks are now beginning to emerge.
T8345	34029-34032	DT	denotes	The
T8346	34045-34049	NNS	denotes	data
T8347	34033-34044	NN	denotes	interaction
T8348	34075-34077	VBZ	denotes	is
T8349	34050-34053	IN	denotes	for
T8350	34054-34057	DT	denotes	the
T8351	34069-34074	NNS	denotes	TACCs
T8352	34058-34068	NN	denotes	vertebrate
T8353	34136-34145	VBG	denotes	beginning
T8354	34078-34088	RB	denotes	relatively
T8355	34089-34096	VBN	denotes	limited
T8356	34096-34097	:	denotes	;
T8357	34098-34105	RB	denotes	however
T8358	34105-34107	,	denotes	,
T8359	34107-34118	NN	denotes	interaction
T8360	34119-34127	NNS	denotes	networks
T8361	34128-34131	VBP	denotes	are
T8362	34132-34135	RB	denotes	now
T8363	34146-34148	TO	denotes	to
T8364	34149-34155	VB	denotes	emerge
T8365	34155-34156	.	denotes	.
T8366	34156-34342	sentence	denotes	The results of our functional analysis, as well as other published data clearly indicate that the vertebrate TACCs interact with proteins that can be divided into two broad categories:
T8367	34157-34160	DT	denotes	The
T8368	34161-34168	NNS	denotes	results
T8369	34237-34245	VBP	denotes	indicate
T8370	34169-34171	IN	denotes	of
T8371	34172-34175	PRP$	denotes	our
T8372	34187-34195	NN	denotes	analysis
T8373	34176-34186	JJ	denotes	functional
T8374	34195-34197	,	denotes	,
T8375	34197-34199	RB	denotes	as
T8376	34205-34207	IN	denotes	as
T8377	34200-34204	RB	denotes	well
T8378	34208-34213	JJ	denotes	other
T8379	34224-34228	NNS	denotes	data
T8380	34214-34223	VBN	denotes	published
T8381	34229-34236	RB	denotes	clearly
T8382	34246-34250	IN	denotes	that
T8383	34272-34280	VBP	denotes	interact
T8384	34251-34254	DT	denotes	the
T8385	34266-34271	NNS	denotes	TACCs
T8386	34255-34265	NN	denotes	vertebrate
T8387	34281-34285	IN	denotes	with
T8388	34286-34294	NN	denotes	proteins
T8389	34295-34299	WDT	denotes	that
T8390	34307-34314	VBN	denotes	divided
T8391	34300-34303	MD	denotes	can
T8392	34304-34306	VB	denotes	be
T8393	34315-34319	IN	denotes	into
T8394	34320-34323	CD	denotes	two
T8395	34330-34340	NNS	denotes	categories
T8396	34324-34329	JJ	denotes	broad
T8397	34340-34342	:	denotes	:
T8398	34342-34343	LS	denotes	1
T8399	34345-34353	NN	denotes	proteins
T8400	34342-34562	sentence	denotes	1) proteins with roles in centrosome/mitotic spindle dynamics, and 2) proteins involved in gene regulation, either at the level of transcription, or subsequent RNA processing and translation [3,5-7,15,19-21,24,25,33,34].
T8401	34343-34344	-RRB-	denotes	)
T8402	34354-34358	IN	denotes	with
T8403	34359-34364	NNS	denotes	roles
T8404	34365-34367	IN	denotes	in
T8405	34368-34378	NN	denotes	centrosome
T8406	34379-34386	JJ	denotes	mitotic
T8407	34378-34379	HYPH	denotes	/
T8408	34387-34394	NN	denotes	spindle
T8409	34395-34403	NNS	denotes	dynamics
T8410	34403-34405	,	denotes	,
T8411	34405-34408	CC	denotes	and
T8412	34409-34410	LS	denotes	2
T8413	34412-34420	NN	denotes	proteins
T8414	34410-34411	-RRB-	denotes	)
T8415	34421-34429	VBN	denotes	involved
T8416	34430-34432	IN	denotes	in
T8417	34433-34437	NN	denotes	gene
T8418	34438-34448	NN	denotes	regulation
T8419	34448-34450	,	denotes	,
T8420	34450-34456	CC	denotes	either
T8421	34457-34459	IN	denotes	at
T8422	34460-34463	DT	denotes	the
T8423	34464-34469	NN	denotes	level
T8424	34470-34472	IN	denotes	of
T8425	34473-34486	NN	denotes	transcription
T8426	34486-34488	,	denotes	,
T8427	34488-34490	CC	denotes	or
T8428	34491-34501	JJ	denotes	subsequent
T8429	34506-34516	NN	denotes	processing
T8430	34502-34505	NN	denotes	RNA
T8431	34517-34520	CC	denotes	and
T8432	34521-34532	NN	denotes	translation
T8433	34533-34534	-LRB-	denotes	[
T8434	34534-34535	CD	denotes	3
T8435	34535-34536	,	denotes	,
T8436	34536-34537	CD	denotes	5
T8437	34537-34538	SYM	denotes	-
T8438	34538-34539	CD	denotes	7
T8439	34539-34540	,	denotes	,
T8440	34540-34542	CD	denotes	15
T8441	34542-34543	,	denotes	,
T8442	34543-34545	CD	denotes	19
T8443	34545-34546	SYM	denotes	-
T8444	34546-34548	CD	denotes	21
T8445	34548-34549	,	denotes	,
T8446	34549-34551	CD	denotes	24
T8447	34551-34552	,	denotes	,
T8448	34552-34554	CD	denotes	25
T8449	34554-34555	,	denotes	,
T8450	34555-34557	CD	denotes	33
T8451	34557-34558	,	denotes	,
T8452	34558-34560	CD	denotes	34
T8453	34560-34561	-RRB-	denotes	]
T8454	34561-34562	.	denotes	.
T8455	34562-34717	sentence	denotes	Many of these proteins do not appear to interact directly with the protostome TACCs, but would be expected to be in the same protein complex (Fig. 6C,6D).
T8456	34563-34567	JJ	denotes	Many
T8457	34593-34599	VB	denotes	appear
T8458	34568-34570	IN	denotes	of
T8459	34571-34576	DT	denotes	these
T8460	34577-34585	NN	denotes	proteins
T8461	34586-34588	VBP	denotes	do
T8462	34589-34592	RB	denotes	not
T8463	34600-34602	TO	denotes	to
T8464	34603-34611	VB	denotes	interact
T8465	34612-34620	RB	denotes	directly
T8466	34621-34625	IN	denotes	with
T8467	34626-34629	DT	denotes	the
T8468	34641-34646	NNS	denotes	TACCs
T8469	34630-34640	NN	denotes	protostome
T8470	34646-34648	,	denotes	,
T8471	34648-34651	CC	denotes	but
T8472	34652-34657	MD	denotes	would
T8473	34661-34669	VBN	denotes	expected
T8474	34658-34660	VB	denotes	be
T8475	34670-34672	TO	denotes	to
T8476	34673-34675	VB	denotes	be
T8477	34676-34678	IN	denotes	in
T8478	34679-34682	DT	denotes	the
T8479	34696-34703	NN	denotes	complex
T8480	34683-34687	JJ	denotes	same
T8481	34688-34695	NN	denotes	protein
T8482	34704-34705	-LRB-	denotes	(
T8483	34713-34715	CD	denotes	6D
T8484	34705-34709	NN	denotes	Fig.
T8485	34710-34712	CD	denotes	6C
T8486	34712-34713	,	denotes	,
T8487	34715-34716	-RRB-	denotes	)
T8488	34716-34717	.	denotes	.
T8489	34717-34888	sentence	denotes	Significant analysis of the association of the TACCs with the centrosome and the dynamics of mitotic spindle assembly from yeast to humans has been published [5,6,21-24].
T8490	34718-34729	JJ	denotes	Significant
T8491	34730-34738	NN	denotes	analysis
T8492	34866-34875	VBN	denotes	published
T8493	34739-34741	IN	denotes	of
T8494	34742-34745	DT	denotes	the
T8495	34746-34757	NN	denotes	association
T8496	34758-34760	IN	denotes	of
T8497	34761-34764	DT	denotes	the
T8498	34765-34770	NNS	denotes	TACCs
T8499	34771-34775	IN	denotes	with
T8500	34776-34779	DT	denotes	the
T8501	34780-34790	NN	denotes	centrosome
T8502	34791-34794	CC	denotes	and
T8503	34795-34798	DT	denotes	the
T8504	34799-34807	NNS	denotes	dynamics
T8505	34808-34810	IN	denotes	of
T8506	34811-34818	JJ	denotes	mitotic
T8507	34819-34826	NN	denotes	spindle
T8508	34827-34835	NN	denotes	assembly
T8509	34836-34840	IN	denotes	from
T8510	34841-34846	NN	denotes	yeast
T8511	34847-34849	IN	denotes	to
T8512	34850-34856	NNS	denotes	humans
T8513	34857-34860	VBZ	denotes	has
T8514	34861-34865	VBN	denotes	been
T8515	34876-34877	-LRB-	denotes	[
T8516	34877-34878	CD	denotes	5
T8517	34878-34879	,	denotes	,
T8518	34879-34880	CD	denotes	6
T8519	34880-34881	,	denotes	,
T8520	34881-34883	CD	denotes	21
T8521	34883-34884	SYM	denotes	-
T8522	34884-34886	CD	denotes	24
T8523	34886-34887	-RRB-	denotes	]
T8524	34887-34888	.	denotes	.
T8525	34888-35208	sentence	denotes	From this analysis, it seems likely that the vertebrate TACC3 protein has retained this direct ancestral function, based upon its location in these structures during mitosis [27], its strong interaction with Aurora Kinase A, and the observation that it is the only human TACC protein phosphorylated by this enzyme [21].
T8526	34889-34893	IN	denotes	From
T8527	34912-34917	VBZ	denotes	seems
T8528	34894-34898	DT	denotes	this
T8529	34899-34907	NN	denotes	analysis
T8530	34907-34909	,	denotes	,
T8531	34909-34911	PRP	denotes	it
T8532	34918-34924	JJ	denotes	likely
T8533	34925-34929	IN	denotes	that
T8534	34963-34971	VBN	denotes	retained
T8535	34930-34933	DT	denotes	the
T8536	34951-34958	NN	denotes	protein
T8537	34934-34944	NN	denotes	vertebrate
T8538	34945-34950	NN	denotes	TACC3
T8539	34959-34962	VBZ	denotes	has
T8540	34972-34976	DT	denotes	this
T8541	34994-35002	NN	denotes	function
T8542	34977-34983	JJ	denotes	direct
T8543	34984-34993	JJ	denotes	ancestral
T8544	35002-35004	,	denotes	,
T8545	35004-35009	VBN	denotes	based
T8546	35010-35014	IN	denotes	upon
T8547	35015-35018	PRP$	denotes	its
T8548	35019-35027	NN	denotes	location
T8549	35028-35030	IN	denotes	in
T8550	35031-35036	DT	denotes	these
T8551	35037-35047	NNS	denotes	structures
T8552	35048-35054	IN	denotes	during
T8553	35055-35062	NN	denotes	mitosis
T8554	35063-35064	-LRB-	denotes	[
T8555	35064-35066	CD	denotes	27
T8556	35066-35067	-RRB-	denotes	]
T8557	35067-35069	,	denotes	,
T8558	35069-35072	PRP$	denotes	its
T8559	35080-35091	NN	denotes	interaction
T8560	35073-35079	JJ	denotes	strong
T8561	35092-35096	IN	denotes	with
T8562	35097-35103	NN	denotes	Aurora
T8563	35111-35112	NN	denotes	A
T8564	35104-35110	NN	denotes	Kinase
T8565	35112-35114	,	denotes	,
T8566	35114-35117	CC	denotes	and
T8567	35118-35121	DT	denotes	the
T8568	35122-35133	NN	denotes	observation
T8569	35134-35138	IN	denotes	that
T8570	35142-35144	VBZ	denotes	is
T8571	35139-35141	PRP	denotes	it
T8572	35145-35148	DT	denotes	the
T8573	35165-35172	NN	denotes	protein
T8574	35149-35153	RB	denotes	only
T8575	35154-35159	JJ	denotes	human
T8576	35160-35164	NN	denotes	TACC
T8577	35173-35187	VBN	denotes	phosphorylated
T8578	35188-35190	IN	denotes	by
T8579	35191-35195	DT	denotes	this
T8580	35196-35202	NN	denotes	enzyme
T8581	35203-35204	-LRB-	denotes	[
T8582	35204-35206	CD	denotes	21
T8583	35206-35207	-RRB-	denotes	]
T8584	35207-35208	.	denotes	.
T8585	35208-35392	sentence	denotes	However, the variability of the central domain of the vertebrate orthologues, suggests that TACC3 may also have acquired additional, and in some instances, species-specific functions.
T8586	35209-35216	RB	denotes	However
T8587	35287-35295	VBZ	denotes	suggests
T8588	35216-35218	,	denotes	,
T8589	35218-35221	DT	denotes	the
T8590	35222-35233	NN	denotes	variability
T8591	35234-35236	IN	denotes	of
T8592	35237-35240	DT	denotes	the
T8593	35249-35255	NN	denotes	domain
T8594	35241-35248	JJ	denotes	central
T8595	35256-35258	IN	denotes	of
T8596	35259-35262	DT	denotes	the
T8597	35274-35285	NNS	denotes	orthologues
T8598	35263-35273	NN	denotes	vertebrate
T8599	35285-35287	,	denotes	,
T8600	35296-35300	IN	denotes	that
T8601	35321-35329	VBN	denotes	acquired
T8602	35301-35306	NN	denotes	TACC3
T8603	35307-35310	MD	denotes	may
T8604	35311-35315	RB	denotes	also
T8605	35316-35320	VB	denotes	have
T8606	35330-35340	JJ	denotes	additional
T8607	35382-35391	NNS	denotes	functions
T8608	35340-35342	,	denotes	,
T8609	35342-35345	CC	denotes	and
T8610	35346-35348	IN	denotes	in
T8611	35373-35381	JJ	denotes	specific
T8612	35349-35353	DT	denotes	some
T8613	35354-35363	NNS	denotes	instances
T8614	35363-35365	,	denotes	,
T8615	35365-35372	NN	denotes	species
T8616	35372-35373	HYPH	denotes	-
T8617	35391-35392	.	denotes	.
T8618	35392-35602	sentence	denotes	For instance, in X. laevis, the maskin protein has acquired a binding site for the eIF4E protein, and thus a function in the coordinated control of polyadenylation and translation in the Xenopus oocyte [8,35].
T8619	35393-35396	IN	denotes	For
T8620	35444-35452	VBN	denotes	acquired
T8621	35397-35405	NN	denotes	instance
T8622	35405-35407	,	denotes	,
T8623	35407-35409	IN	denotes	in
T8624	35410-35412	NNP	denotes	X.
T8625	35413-35419	NNP	denotes	laevis
T8626	35419-35421	,	denotes	,
T8627	35421-35424	DT	denotes	the
T8628	35432-35439	NN	denotes	protein
T8629	35425-35431	NN	denotes	maskin
T8630	35440-35443	VBZ	denotes	has
T8631	35453-35454	DT	denotes	a
T8632	35463-35467	NN	denotes	site
T8633	35455-35462	NN	denotes	binding
T8634	35468-35471	IN	denotes	for
T8635	35472-35475	DT	denotes	the
T8636	35482-35489	NN	denotes	protein
T8637	35476-35481	NN	denotes	eIF4E
T8638	35489-35491	,	denotes	,
T8639	35491-35494	CC	denotes	and
T8640	35495-35499	RB	denotes	thus
T8641	35502-35510	NN	denotes	function
T8642	35500-35501	DT	denotes	a
T8643	35511-35513	IN	denotes	in
T8644	35514-35517	DT	denotes	the
T8645	35530-35537	NN	denotes	control
T8646	35518-35529	VBN	denotes	coordinated
T8647	35538-35540	IN	denotes	of
T8648	35541-35556	NN	denotes	polyadenylation
T8649	35557-35560	CC	denotes	and
T8650	35561-35572	NN	denotes	translation
T8651	35573-35575	IN	denotes	in
T8652	35576-35579	DT	denotes	the
T8653	35588-35594	NN	denotes	oocyte
T8654	35580-35587	NNP	denotes	Xenopus
T8655	35595-35596	-LRB-	denotes	[
T8656	35598-35600	CD	denotes	35
T8657	35596-35597	CD	denotes	8
T8658	35597-35598	,	denotes	,
T8659	35600-35601	-RRB-	denotes	]
T8660	35601-35602	.	denotes	.
T8661	35602-35856	sentence	denotes	A recent study has suggested that this function may be unique to maskin: although it is unclear whether the other vertebrate TACC3 proteins interact with the eIF4E/CPEB complex, the human TACC1A isoform is unable to interact with the eIF4E/CPEB complex.
T8662	35603-35604	DT	denotes	A
T8663	35612-35617	NN	denotes	study
T8664	35605-35611	JJ	denotes	recent
T8665	35622-35631	VBN	denotes	suggested
T8666	35618-35621	VBZ	denotes	has
T8667	35806-35808	VBZ	denotes	is
T8668	35632-35636	IN	denotes	that
T8669	35655-35657	VB	denotes	be
T8670	35637-35641	DT	denotes	this
T8671	35642-35650	NN	denotes	function
T8672	35651-35654	MD	denotes	may
T8673	35658-35664	JJ	denotes	unique
T8674	35665-35667	IN	denotes	to
T8675	35668-35674	NN	denotes	maskin
T8676	35674-35676	:	denotes	:
T8677	35676-35684	IN	denotes	although
T8678	35688-35690	VBZ	denotes	is
T8679	35685-35687	PRP	denotes	it
T8680	35691-35698	JJ	denotes	unclear
T8681	35699-35706	IN	denotes	whether
T8682	35743-35751	VBP	denotes	interact
T8683	35707-35710	DT	denotes	the
T8684	35734-35742	NN	denotes	proteins
T8685	35711-35716	JJ	denotes	other
T8686	35717-35727	NN	denotes	vertebrate
T8687	35728-35733	NN	denotes	TACC3
T8688	35752-35756	IN	denotes	with
T8689	35757-35760	DT	denotes	the
T8690	35772-35779	NN	denotes	complex
T8691	35761-35766	NN	denotes	eIF4E
T8692	35767-35771	NN	denotes	CPEB
T8693	35766-35767	HYPH	denotes	/
T8694	35779-35781	,	denotes	,
T8695	35781-35784	DT	denotes	the
T8696	35798-35805	NN	denotes	isoform
T8697	35785-35790	JJ	denotes	human
T8698	35791-35797	NN	denotes	TACC1A
T8699	35809-35815	JJ	denotes	unable
T8700	35816-35818	TO	denotes	to
T8701	35819-35827	VB	denotes	interact
T8702	35828-35832	IN	denotes	with
T8703	35833-35836	DT	denotes	the
T8704	35848-35855	NN	denotes	complex
T8705	35837-35842	NN	denotes	eIF4E
T8706	35843-35847	NN	denotes	CPEB
T8707	35842-35843	HYPH	denotes	/
T8708	35855-35856	.	denotes	.
T8709	35856-36019	sentence	denotes	Instead, some TACC1 isoforms have evolved a related, but distinct function by directly interacting with elements of the RNA splicing and transport machinery [19].
T8710	35857-35864	RB	denotes	Instead
T8711	35891-35898	VBN	denotes	evolved
T8712	35864-35866	,	denotes	,
T8713	35866-35870	DT	denotes	some
T8714	35877-35885	NNS	denotes	isoforms
T8715	35871-35876	NN	denotes	TACC1
T8716	35886-35890	VBP	denotes	have
T8717	35899-35900	DT	denotes	a
T8718	35923-35931	NN	denotes	function
T8719	35901-35908	JJ	denotes	related
T8720	35908-35910	,	denotes	,
T8721	35910-35913	CC	denotes	but
T8722	35914-35922	JJ	denotes	distinct
T8723	35932-35934	IN	denotes	by
T8724	35935-35943	RB	denotes	directly
T8725	35944-35955	VBG	denotes	interacting
T8726	35956-35960	IN	denotes	with
T8727	35961-35969	NNS	denotes	elements
T8728	35970-35972	IN	denotes	of
T8729	35973-35976	DT	denotes	the
T8730	36004-36013	NN	denotes	machinery
T8731	35977-35980	NN	denotes	RNA
T8732	35981-35989	NN	denotes	splicing
T8733	35990-35993	CC	denotes	and
T8734	35994-36003	NN	denotes	transport
T8735	36014-36015	-LRB-	denotes	[
T8736	36015-36017	CD	denotes	19
T8737	36017-36018	-RRB-	denotes	]
T8738	36018-36019	.	denotes	.
T8739	36019-36213	sentence	denotes	To further characterize the evolving functions of the TACC proteins, we have used an unbiased yeast two hybrid screening method to identify proteins that bind to the human TACC proteins [3,34].
T8740	36020-36022	TO	denotes	To
T8741	36031-36043	VB	denotes	characterize
T8742	36023-36030	RB	denotes	further
T8743	36097-36101	VBN	denotes	used
T8744	36044-36047	DT	denotes	the
T8745	36057-36066	NNS	denotes	functions
T8746	36048-36056	VBG	denotes	evolving
T8747	36067-36069	IN	denotes	of
T8748	36070-36073	DT	denotes	the
T8749	36079-36087	NN	denotes	proteins
T8750	36074-36078	NN	denotes	TACC
T8751	36087-36089	,	denotes	,
T8752	36089-36091	PRP	denotes	we
T8753	36092-36096	VBP	denotes	have
T8754	36102-36104	DT	denotes	an
T8755	36141-36147	NN	denotes	method
T8756	36105-36113	JJ	denotes	unbiased
T8757	36114-36119	NN	denotes	yeast
T8758	36120-36123	CD	denotes	two
T8759	36124-36130	NN	denotes	hybrid
T8760	36131-36140	NN	denotes	screening
T8761	36148-36150	TO	denotes	to
T8762	36151-36159	VB	denotes	identify
T8763	36160-36168	NN	denotes	proteins
T8764	36169-36173	WDT	denotes	that
T8765	36174-36178	VBP	denotes	bind
T8766	36179-36181	IN	denotes	to
T8767	36182-36185	DT	denotes	the
T8768	36197-36205	NN	denotes	proteins
T8769	36186-36191	JJ	denotes	human
T8770	36192-36196	NN	denotes	TACC
T8771	36206-36207	-LRB-	denotes	[
T8772	36209-36211	CD	denotes	34
T8773	36207-36208	CD	denotes	3
T8774	36208-36209	,	denotes	,
T8775	36211-36212	-RRB-	denotes	]
T8776	36212-36213	.	denotes	.
T8777	36213-36475	sentence	denotes	In a screen of a MATCHMAKER fetal brain library (BD Biosciences Clontech), in addition to isolating the histone acetyltransferase hGCN5L2 [34], we also identified the β3 isoform of retinoid-X receptor β as a protein that interacts with the TACC domain of TACC2.
T8778	36214-36216	IN	denotes	In
T8779	36366-36376	VBD	denotes	identified
T8780	36217-36218	DT	denotes	a
T8781	36219-36225	NN	denotes	screen
T8782	36226-36228	IN	denotes	of
T8783	36229-36230	DT	denotes	a
T8784	36254-36261	NN	denotes	library
T8785	36231-36241	NN	denotes	MATCHMAKER
T8786	36242-36247	JJ	denotes	fetal
T8787	36248-36253	NN	denotes	brain
T8788	36262-36263	-LRB-	denotes	(
T8789	36278-36286	NNP	denotes	Clontech
T8790	36263-36265	NNP	denotes	BD
T8791	36266-36277	NNPS	denotes	Biosciences
T8792	36286-36287	-RRB-	denotes	)
T8793	36287-36289	,	denotes	,
T8794	36289-36291	IN	denotes	in
T8795	36292-36300	NN	denotes	addition
T8796	36301-36303	IN	denotes	to
T8797	36304-36313	VBG	denotes	isolating
T8798	36314-36317	DT	denotes	the
T8799	36326-36343	NN	denotes	acetyltransferase
T8800	36318-36325	NN	denotes	histone
T8801	36344-36351	NN	denotes	hGCN5L2
T8802	36352-36353	-LRB-	denotes	[
T8803	36353-36355	CD	denotes	34
T8804	36355-36356	-RRB-	denotes	]
T8805	36356-36358	,	denotes	,
T8806	36358-36360	PRP	denotes	we
T8807	36361-36365	RB	denotes	also
T8808	36377-36380	DT	denotes	the
T8809	36384-36391	NN	denotes	isoform
T8810	36381-36383	NN	denotes	β3
T8811	36392-36394	IN	denotes	of
T8812	36395-36403	NN	denotes	retinoid
T8813	36404-36405	NN	denotes	X
T8814	36403-36404	HYPH	denotes	-
T8815	36415-36416	NN	denotes	β
T8816	36406-36414	NN	denotes	receptor
T8817	36417-36419	IN	denotes	as
T8818	36420-36421	DT	denotes	a
T8819	36422-36429	NN	denotes	protein
T8820	36430-36434	WDT	denotes	that
T8821	36435-36444	VBZ	denotes	interacts
T8822	36445-36449	IN	denotes	with
T8823	36450-36453	DT	denotes	the
T8824	36459-36465	NN	denotes	domain
T8825	36454-36458	NN	denotes	TACC
T8826	36466-36468	IN	denotes	of
T8827	36469-36474	NN	denotes	TACC2
T8828	36474-36475	.	denotes	.
T8829	36475-36561	sentence	denotes	As shown in Fig. 7, this interaction is confirmed in vitro by GST-pull down analysis.
T8830	36476-36478	IN	denotes	As
T8831	36479-36484	VBN	denotes	shown
T8832	36516-36525	VBN	denotes	confirmed
T8833	36485-36487	IN	denotes	in
T8834	36488-36492	NN	denotes	Fig.
T8835	36493-36494	CD	denotes	7
T8836	36494-36496	,	denotes	,
T8837	36496-36500	DT	denotes	this
T8838	36501-36512	NN	denotes	interaction
T8839	36513-36515	VBZ	denotes	is
T8840	36526-36528	FW	denotes	in
T8841	36529-36534	FW	denotes	vitro
T8842	36535-36537	IN	denotes	by
T8843	36538-36541	NN	denotes	GST
T8844	36542-36546	VB	denotes	pull
T8845	36541-36542	HYPH	denotes	-
T8846	36552-36560	NN	denotes	analysis
T8847	36547-36551	RP	denotes	down
T8848	36560-36561	.	denotes	.
T8849	36561-36730	sentence	denotes	Significantly, RXRβ is a close family relative of the nuclear hormone receptor, nhr-86, from C. elegans, which interacts with the ceTAC binding protein lin36 (Fig. 6A).
T8850	36562-36575	RB	denotes	Significantly
T8851	36582-36584	VBZ	denotes	is
T8852	36575-36577	,	denotes	,
T8853	36577-36581	NN	denotes	RXRβ
T8854	36585-36586	DT	denotes	a
T8855	36593-36599	NN	denotes	family
T8856	36587-36592	JJ	denotes	close
T8857	36600-36608	JJ	denotes	relative
T8858	36609-36611	IN	denotes	of
T8859	36612-36615	DT	denotes	the
T8860	36632-36640	NN	denotes	receptor
T8861	36616-36623	JJ	denotes	nuclear
T8862	36624-36631	NN	denotes	hormone
T8863	36640-36642	,	denotes	,
T8864	36642-36645	NN	denotes	nhr
T8865	36645-36646	HYPH	denotes	-
T8866	36646-36648	CD	denotes	86
T8867	36648-36650	,	denotes	,
T8868	36650-36654	IN	denotes	from
T8869	36655-36657	NNP	denotes	C.
T8870	36658-36665	NNP	denotes	elegans
T8871	36665-36667	,	denotes	,
T8872	36667-36672	WDT	denotes	which
T8873	36673-36682	VBZ	denotes	interacts
T8874	36683-36687	IN	denotes	with
T8875	36688-36691	DT	denotes	the
T8876	36706-36713	NN	denotes	protein
T8877	36692-36697	NN	denotes	ceTAC
T8878	36698-36705	NN	denotes	binding
T8879	36714-36719	NN	denotes	lin36
T8880	36720-36721	-LRB-	denotes	(
T8881	36721-36725	NN	denotes	Fig.
T8882	36726-36728	CD	denotes	6A
T8883	36728-36729	-RRB-	denotes	)
T8884	36729-36730	.	denotes	.
T8885	36730-36995	sentence	denotes	This suggests that while protostome TACCs may require additional protein factors to interact with such components, the TACCs in higher organisms may have evolved the ability to directly interact with some of the proteins in the predicted interaction map (Fig. 6E).
T8886	36731-36735	DT	denotes	This
T8887	36736-36744	VBZ	denotes	suggests
T8888	36745-36749	IN	denotes	that
T8889	36885-36892	VBN	denotes	evolved
T8890	36750-36755	IN	denotes	while
T8891	36777-36784	VB	denotes	require
T8892	36756-36766	NN	denotes	protostome
T8893	36767-36772	NNS	denotes	TACCs
T8894	36773-36776	MD	denotes	may
T8895	36785-36795	JJ	denotes	additional
T8896	36804-36811	NNS	denotes	factors
T8897	36796-36803	NN	denotes	protein
T8898	36812-36814	TO	denotes	to
T8899	36815-36823	VB	denotes	interact
T8900	36824-36828	IN	denotes	with
T8901	36829-36833	JJ	denotes	such
T8902	36834-36844	NNS	denotes	components
T8903	36844-36846	,	denotes	,
T8904	36846-36849	DT	denotes	the
T8905	36850-36855	NNS	denotes	TACCs
T8906	36856-36858	IN	denotes	in
T8907	36859-36865	JJR	denotes	higher
T8908	36866-36875	NNS	denotes	organisms
T8909	36876-36879	MD	denotes	may
T8910	36880-36884	VB	denotes	have
T8911	36893-36896	DT	denotes	the
T8912	36897-36904	NN	denotes	ability
T8913	36905-36907	TO	denotes	to
T8914	36917-36925	VB	denotes	interact
T8915	36908-36916	RB	denotes	directly
T8916	36926-36930	IN	denotes	with
T8917	36931-36935	DT	denotes	some
T8918	36936-36938	IN	denotes	of
T8919	36939-36942	DT	denotes	the
T8920	36943-36951	NN	denotes	proteins
T8921	36952-36954	IN	denotes	in
T8922	36955-36958	DT	denotes	the
T8923	36981-36984	NN	denotes	map
T8924	36959-36968	VBN	denotes	predicted
T8925	36969-36980	NN	denotes	interaction
T8926	36985-36986	-LRB-	denotes	(
T8927	36986-36990	NN	denotes	Fig.
T8928	36991-36993	CD	denotes	6E
T8929	36993-36994	-RRB-	denotes	)
T8930	36994-36995	.	denotes	.
T8931	36995-37120	sentence	denotes	Indeed, this appears to be directly linked to the acquisition of new domains and duplication of the chordate TACC precursor.
T8932	36996-37002	RB	denotes	Indeed
T8933	37009-37016	VBZ	denotes	appears
T8934	37002-37004	,	denotes	,
T8935	37004-37008	DT	denotes	this
T8936	37017-37019	TO	denotes	to
T8937	37032-37038	VBN	denotes	linked
T8938	37020-37022	VB	denotes	be
T8939	37023-37031	RB	denotes	directly
T8940	37039-37041	IN	denotes	to
T8941	37042-37045	DT	denotes	the
T8942	37046-37057	NN	denotes	acquisition
T8943	37058-37060	IN	denotes	of
T8944	37061-37064	JJ	denotes	new
T8945	37065-37072	NNS	denotes	domains
T8946	37073-37076	CC	denotes	and
T8947	37077-37088	NN	denotes	duplication
T8948	37089-37091	IN	denotes	of
T8949	37092-37095	DT	denotes	the
T8950	37110-37119	NN	denotes	precursor
T8951	37096-37104	NN	denotes	chordate
T8952	37105-37109	NN	denotes	TACC
T8953	37119-37120	.	denotes	.
T8954	37120-37301	sentence	denotes	In fact, the first identified function of a vertebrate TACC protein was as a transcriptional coactivator acting through a direct interaction with the ARNT transcription factor [7].
T8955	37121-37123	IN	denotes	In
T8956	37189-37192	VBD	denotes	was
T8957	37124-37128	NN	denotes	fact
T8958	37128-37130	,	denotes	,
T8959	37130-37133	DT	denotes	the
T8960	37151-37159	NN	denotes	function
T8961	37134-37139	JJ	denotes	first
T8962	37140-37150	VBN	denotes	identified
T8963	37160-37162	IN	denotes	of
T8964	37163-37164	DT	denotes	a
T8965	37181-37188	NN	denotes	protein
T8966	37165-37175	NN	denotes	vertebrate
T8967	37176-37180	NN	denotes	TACC
T8968	37193-37195	IN	denotes	as
T8969	37196-37197	DT	denotes	a
T8970	37214-37225	NN	denotes	coactivator
T8971	37198-37213	JJ	denotes	transcriptional
T8972	37226-37232	VBG	denotes	acting
T8973	37233-37240	IN	denotes	through
T8974	37241-37242	DT	denotes	a
T8975	37250-37261	NN	denotes	interaction
T8976	37243-37249	JJ	denotes	direct
T8977	37262-37266	IN	denotes	with
T8978	37267-37270	DT	denotes	the
T8979	37290-37296	NN	denotes	factor
T8980	37271-37275	NN	denotes	ARNT
T8981	37276-37289	NN	denotes	transcription
T8982	37297-37298	-LRB-	denotes	[
T8983	37298-37299	CD	denotes	7
T8984	37299-37300	-RRB-	denotes	]
T8985	37300-37301	.	denotes	.
T8986	37301-37474	sentence	denotes	It is also intriguing that the deuterostome specific SDP repeat interacts with GAS41, a component/accessory factor of the human SWI/SNF chromatin remodeling complex [3,15].
T8987	37302-37304	PRP	denotes	It
T8988	37305-37307	VBZ	denotes	is
T8989	37308-37312	RB	denotes	also
T8990	37313-37323	JJ	denotes	intriguing
T8991	37324-37328	IN	denotes	that
T8992	37366-37375	VBZ	denotes	interacts
T8993	37329-37332	DT	denotes	the
T8994	37359-37365	NN	denotes	repeat
T8995	37333-37345	NN	denotes	deuterostome
T8996	37346-37354	JJ	denotes	specific
T8997	37355-37358	NN	denotes	SDP
T8998	37376-37380	IN	denotes	with
T8999	37381-37386	NN	denotes	GAS41
T9000	37386-37388	,	denotes	,
T9001	37388-37389	DT	denotes	a
T9002	37410-37416	NN	denotes	factor
T9003	37390-37399	NN	denotes	component
T9004	37400-37409	NN	denotes	accessory
T9005	37399-37400	HYPH	denotes	/
T9006	37417-37419	IN	denotes	of
T9007	37420-37423	DT	denotes	the
T9008	37459-37466	NN	denotes	complex
T9009	37424-37429	JJ	denotes	human
T9010	37430-37433	NN	denotes	SWI
T9011	37434-37437	NN	denotes	SNF
T9012	37433-37434	HYPH	denotes	/
T9013	37438-37447	NN	denotes	chromatin
T9014	37448-37458	NN	denotes	remodeling
T9015	37467-37468	-LRB-	denotes	[
T9016	37470-37472	CD	denotes	15
T9017	37468-37469	CD	denotes	3
T9018	37469-37470	,	denotes	,
T9019	37472-37473	-RRB-	denotes	]
T9020	37473-37474	.	denotes	.
T9021	37474-37648	sentence	denotes	Although there is a D. melanogaster homologue of GAS41, dmGAS41, the large scale proteomic interaction database does not indicate a direct interaction of dmGAS41 with DTACC.
T9022	37475-37483	IN	denotes	Although
T9023	37490-37492	VBZ	denotes	is
T9024	37484-37489	EX	denotes	there
T9025	37596-37604	VB	denotes	indicate
T9026	37493-37494	DT	denotes	a
T9027	37511-37520	NN	denotes	homologue
T9028	37495-37497	NNP	denotes	D.
T9029	37498-37510	NNP	denotes	melanogaster
T9030	37521-37523	IN	denotes	of
T9031	37524-37529	NN	denotes	GAS41
T9032	37529-37531	,	denotes	,
T9033	37531-37538	NN	denotes	dmGAS41
T9034	37538-37540	,	denotes	,
T9035	37540-37543	DT	denotes	the
T9036	37578-37586	NN	denotes	database
T9037	37544-37549	JJ	denotes	large
T9038	37550-37555	NN	denotes	scale
T9039	37566-37577	NN	denotes	interaction
T9040	37556-37565	JJ	denotes	proteomic
T9041	37587-37591	VBZ	denotes	does
T9042	37592-37595	RB	denotes	not
T9043	37605-37606	DT	denotes	a
T9044	37614-37625	NN	denotes	interaction
T9045	37607-37613	JJ	denotes	direct
T9046	37626-37628	IN	denotes	of
T9047	37629-37636	NN	denotes	dmGAS41
T9048	37637-37641	IN	denotes	with
T9049	37642-37647	NN	denotes	DTACC
T9050	37647-37648	.	denotes	.
T9051	37648-37733	sentence	denotes	This may be due to the lack of the SDP repeat region in the Drosophila TACC protein.
T9052	37649-37653	DT	denotes	This
T9053	37658-37660	VB	denotes	be
T9054	37654-37657	MD	denotes	may
T9055	37661-37664	IN	denotes	due
T9056	37665-37667	IN	denotes	to
T9057	37668-37671	DT	denotes	the
T9058	37672-37676	NN	denotes	lack
T9059	37677-37679	IN	denotes	of
T9060	37680-37683	DT	denotes	the
T9061	37695-37701	NN	denotes	region
T9062	37684-37687	NN	denotes	SDP
T9063	37688-37694	NN	denotes	repeat
T9064	37702-37704	IN	denotes	in
T9065	37705-37708	DT	denotes	the
T9066	37725-37732	NN	denotes	protein
T9067	37709-37719	NNP	denotes	Drosophila
T9068	37720-37724	NN	denotes	TACC
T9069	37732-37733	.	denotes	.
T9070	37733-37929	sentence	denotes	This further suggests that the vertebrate TACCs have gained the specific ability to direct interact with transcriptional regulatory complexes, and that bridging protein(s) are no longer required.
T9071	37734-37738	DT	denotes	This
T9072	37747-37755	VBZ	denotes	suggests
T9073	37739-37746	RB	denotes	further
T9074	37756-37760	IN	denotes	that
T9075	37787-37793	VBN	denotes	gained
T9076	37761-37764	DT	denotes	the
T9077	37776-37781	NNS	denotes	TACCs
T9078	37765-37775	NN	denotes	vertebrate
T9079	37782-37786	VBP	denotes	have
T9080	37794-37797	DT	denotes	the
T9081	37807-37814	NN	denotes	ability
T9082	37798-37806	JJ	denotes	specific
T9083	37815-37817	TO	denotes	to
T9084	37825-37833	VB	denotes	interact
T9085	37818-37824	JJ	denotes	direct
T9086	37834-37838	IN	denotes	with
T9087	37839-37854	JJ	denotes	transcriptional
T9088	37866-37875	NNS	denotes	complexes
T9089	37855-37865	JJ	denotes	regulatory
T9090	37875-37877	,	denotes	,
T9091	37877-37880	CC	denotes	and
T9092	37881-37885	IN	denotes	that
T9093	37920-37928	VBN	denotes	required
T9094	37886-37894	VBG	denotes	bridging
T9095	37895-37902	NN	denotes	protein
T9096	37902-37903	-LRB-	denotes	(
T9097	37903-37904	AFX	denotes	s
T9098	37904-37905	-RRB-	denotes	)
T9099	37906-37909	VBP	denotes	are
T9100	37910-37912	RB	denotes	no
T9101	37913-37919	RBR	denotes	longer
T9102	37928-37929	.	denotes	.
T9103	37929-38186	sentence	denotes	Thus, where the ceTAC protein is only composed of the TACC domain, the significantly larger TACC family members in higher protostomes and deuterostomes may have integrated one or more functions of the bridging protein (in this case lin15A, lin36 or lin37).
T9104	37930-37934	RB	denotes	Thus
T9105	38091-38101	VBN	denotes	integrated
T9106	37934-37936	,	denotes	,
T9107	37936-37941	WRB	denotes	where
T9108	37968-37976	VBN	denotes	composed
T9109	37942-37945	DT	denotes	the
T9110	37952-37959	NN	denotes	protein
T9111	37946-37951	NN	denotes	ceTAC
T9112	37960-37962	VBZ	denotes	is
T9113	37963-37967	RB	denotes	only
T9114	37977-37979	IN	denotes	of
T9115	37980-37983	DT	denotes	the
T9116	37989-37995	NN	denotes	domain
T9117	37984-37988	NN	denotes	TACC
T9118	37995-37997	,	denotes	,
T9119	37997-38000	DT	denotes	the
T9120	38034-38041	NNS	denotes	members
T9121	38001-38014	RB	denotes	significantly
T9122	38015-38021	JJR	denotes	larger
T9123	38022-38026	NN	denotes	TACC
T9124	38027-38033	NN	denotes	family
T9125	38042-38044	IN	denotes	in
T9126	38045-38051	JJR	denotes	higher
T9127	38052-38063	NNS	denotes	protostomes
T9128	38064-38067	CC	denotes	and
T9129	38068-38081	NNS	denotes	deuterostomes
T9130	38082-38085	MD	denotes	may
T9131	38086-38090	VB	denotes	have
T9132	38102-38105	CD	denotes	one
T9133	38114-38123	NNS	denotes	functions
T9134	38106-38108	CC	denotes	or
T9135	38109-38113	JJR	denotes	more
T9136	38124-38126	IN	denotes	of
T9137	38127-38130	DT	denotes	the
T9138	38140-38147	NN	denotes	protein
T9139	38131-38139	VBG	denotes	bridging
T9140	38148-38149	-LRB-	denotes	(
T9141	38149-38151	IN	denotes	in
T9142	38152-38156	DT	denotes	this
T9143	38157-38161	NN	denotes	case
T9144	38162-38168	NN	denotes	lin15A
T9145	38168-38170	,	denotes	,
T9146	38170-38175	NN	denotes	lin36
T9147	38176-38178	CC	denotes	or
T9148	38179-38184	NN	denotes	lin37
T9149	38184-38185	-RRB-	denotes	)
T9150	38185-38186	.	denotes	.
T9151	38186-38408	sentence	denotes	This may also explain the absence of lin15A, lin36 and lin37 homologues in higher organisms, as they were no longer under selective evolutionary pressure to remain within the complex, and thus lost in the evolving genome.
T9152	38187-38191	DT	denotes	This
T9153	38201-38208	VB	denotes	explain
T9154	38192-38195	MD	denotes	may
T9155	38196-38200	RB	denotes	also
T9156	38209-38212	DT	denotes	the
T9157	38213-38220	NN	denotes	absence
T9158	38221-38223	IN	denotes	of
T9159	38224-38230	NN	denotes	lin15A
T9160	38248-38258	NNS	denotes	homologues
T9161	38230-38232	,	denotes	,
T9162	38232-38237	NN	denotes	lin36
T9163	38238-38241	CC	denotes	and
T9164	38242-38247	NN	denotes	lin37
T9165	38259-38261	IN	denotes	in
T9166	38262-38268	JJR	denotes	higher
T9167	38269-38278	NNS	denotes	organisms
T9168	38278-38280	,	denotes	,
T9169	38280-38282	IN	denotes	as
T9170	38288-38292	VBD	denotes	were
T9171	38283-38287	PRP	denotes	they
T9172	38293-38295	RB	denotes	no
T9173	38296-38302	RBR	denotes	longer
T9174	38303-38308	IN	denotes	under
T9175	38309-38318	JJ	denotes	selective
T9176	38332-38340	NN	denotes	pressure
T9177	38319-38331	JJ	denotes	evolutionary
T9178	38341-38343	TO	denotes	to
T9179	38344-38350	VB	denotes	remain
T9180	38351-38357	IN	denotes	within
T9181	38358-38361	DT	denotes	the
T9182	38362-38369	NN	denotes	complex
T9183	38369-38371	,	denotes	,
T9184	38371-38374	CC	denotes	and
T9185	38375-38379	RB	denotes	thus
T9186	38380-38384	VBN	denotes	lost
T9187	38385-38387	IN	denotes	in
T9188	38388-38391	DT	denotes	the
T9189	38401-38407	NN	denotes	genome
T9190	38392-38400	VBG	denotes	evolving
T9191	38407-38408	.	denotes	.
T9492	38797-38805	VBN	denotes	Proposed
T9493	38817-38826	NN	denotes	evolution
T9494	38806-38816	JJ	denotes	functional
T9495	38827-38829	IN	denotes	of
T9496	38830-38833	DT	denotes	the
T9497	38839-38845	NN	denotes	family
T9498	38834-38838	NN	denotes	TACC
T9499	38845-38964	sentence	denotes	Examination of the evolution of ancient gene families provides an insight into how gene structure relates to function.
T9500	38846-38857	NN	denotes	Examination
T9501	38900-38908	VBZ	denotes	provides
T9502	38858-38860	IN	denotes	of
T9503	38861-38864	DT	denotes	the
T9504	38865-38874	NN	denotes	evolution
T9505	38875-38877	IN	denotes	of
T9506	38878-38885	JJ	denotes	ancient
T9507	38891-38899	NNS	denotes	families
T9508	38886-38890	NN	denotes	gene
T9509	38909-38911	DT	denotes	an
T9510	38912-38919	NN	denotes	insight
T9511	38920-38924	IN	denotes	into
T9512	38925-38928	WRB	denotes	how
T9513	38944-38951	VBZ	denotes	relates
T9514	38929-38933	NN	denotes	gene
T9515	38934-38943	NN	denotes	structure
T9516	38952-38954	IN	denotes	to
T9517	38955-38963	NN	denotes	function
T9518	38963-38964	.	denotes	.
T9519	38964-39037	sentence	denotes	We have presented above, a detailed examination of one such gene family.
T9520	38965-38967	PRP	denotes	We
T9521	38973-38982	VBN	denotes	presented
T9522	38968-38972	VBP	denotes	have
T9523	38983-38988	RB	denotes	above
T9524	38988-38990	,	denotes	,
T9525	38990-38991	DT	denotes	a
T9526	39001-39012	NN	denotes	examination
T9527	38992-39000	JJ	denotes	detailed
T9528	39013-39015	IN	denotes	of
T9529	39016-39019	CD	denotes	one
T9530	39030-39036	NN	denotes	family
T9531	39020-39024	JJ	denotes	such
T9532	39025-39029	NN	denotes	gene
T9533	39036-39037	.	denotes	.
T9534	39037-39182	sentence	denotes	The data so far suggest that the functional TACC homologue in yeast (spc72) has a specific role in centrosomal/mitotic spindle dynamics [21,22].
T9535	39038-39041	DT	denotes	The
T9536	39042-39046	NNS	denotes	data
T9537	39054-39061	VBP	denotes	suggest
T9538	39047-39049	RB	denotes	so
T9539	39050-39053	RB	denotes	far
T9540	39062-39066	IN	denotes	that
T9541	39114-39117	VBZ	denotes	has
T9542	39067-39070	DT	denotes	the
T9543	39087-39096	NN	denotes	homologue
T9544	39071-39081	JJ	denotes	functional
T9545	39082-39086	NN	denotes	TACC
T9546	39097-39099	IN	denotes	in
T9547	39100-39105	NN	denotes	yeast
T9548	39106-39107	-LRB-	denotes	(
T9549	39107-39112	NN	denotes	spc72
T9550	39112-39113	-RRB-	denotes	)
T9551	39118-39119	DT	denotes	a
T9552	39129-39133	NN	denotes	role
T9553	39120-39128	JJ	denotes	specific
T9554	39134-39136	IN	denotes	in
T9555	39137-39148	JJ	denotes	centrosomal
T9556	39149-39156	JJ	denotes	mitotic
T9557	39148-39149	HYPH	denotes	/
T9558	39157-39164	NN	denotes	spindle
T9559	39165-39173	NNS	denotes	dynamics
T9560	39174-39175	-LRB-	denotes	[
T9561	39178-39180	CD	denotes	22
T9562	39175-39177	CD	denotes	21
T9563	39177-39178	,	denotes	,
T9564	39180-39181	-RRB-	denotes	]
T9565	39181-39182	.	denotes	.
T9566	39182-39282	sentence	denotes	This ancient TACC function is conserved throughout evolution in both protostomes and deuterostomes.
T9567	39183-39187	DT	denotes	This
T9568	39201-39209	NN	denotes	function
T9569	39188-39195	JJ	denotes	ancient
T9570	39196-39200	NN	denotes	TACC
T9571	39213-39222	VBN	denotes	conserved
T9572	39210-39212	VBZ	denotes	is
T9573	39223-39233	IN	denotes	throughout
T9574	39234-39243	NN	denotes	evolution
T9575	39244-39246	IN	denotes	in
T9576	39247-39251	CC	denotes	both
T9577	39252-39263	NNS	denotes	protostomes
T9578	39264-39267	CC	denotes	and
T9579	39268-39281	NNS	denotes	deuterostomes
T9580	39281-39282	.	denotes	.
T9581	39282-39519	sentence	denotes	In addition, the TACC proteins of lower organisms appear to interact with bridging proteins that are components of several different protein complexes involved in DNA damage repair, protein translation, RNA processing and transcription.
T9582	39283-39285	IN	denotes	In
T9583	39333-39339	VBP	denotes	appear
T9584	39286-39294	NN	denotes	addition
T9585	39294-39296	,	denotes	,
T9586	39296-39299	DT	denotes	the
T9587	39305-39313	NN	denotes	proteins
T9588	39300-39304	NN	denotes	TACC
T9589	39314-39316	IN	denotes	of
T9590	39317-39322	JJR	denotes	lower
T9591	39323-39332	NNS	denotes	organisms
T9592	39340-39342	TO	denotes	to
T9593	39343-39351	VB	denotes	interact
T9594	39352-39356	IN	denotes	with
T9595	39357-39365	NN	denotes	bridging
T9596	39366-39374	NN	denotes	proteins
T9597	39375-39379	WDT	denotes	that
T9598	39380-39383	VBP	denotes	are
T9599	39384-39394	NNS	denotes	components
T9600	39395-39397	IN	denotes	of
T9601	39398-39405	JJ	denotes	several
T9602	39424-39433	NNS	denotes	complexes
T9603	39406-39415	JJ	denotes	different
T9604	39416-39423	NN	denotes	protein
T9605	39434-39442	VBN	denotes	involved
T9606	39443-39445	IN	denotes	in
T9607	39446-39449	NN	denotes	DNA
T9608	39450-39456	NN	denotes	damage
T9609	39457-39463	NN	denotes	repair
T9610	39463-39465	,	denotes	,
T9611	39465-39472	NN	denotes	protein
T9612	39473-39484	NN	denotes	translation
T9613	39484-39486	,	denotes	,
T9614	39486-39489	NN	denotes	RNA
T9615	39490-39500	NN	denotes	processing
T9616	39501-39504	CC	denotes	and
T9617	39505-39518	NN	denotes	transcription
T9618	39518-39519	.	denotes	.
T9619	39519-39948	sentence	denotes	However, over the process of evolutionary time, with the acquisition of new domains and duplication of the chordate TACC precursor, the chordate TACC proteins have acquired the ability to directly interact with some of the other components of these complexes (such as the LSm proteins, nuclear hormone receptors, GAS41, accessory proteins and transcription factors), and thus evolved additional functions within these complexes.
T9620	39520-39527	RB	denotes	However
T9621	39684-39692	VBN	denotes	acquired
T9622	39527-39529	,	denotes	,
T9623	39529-39533	IN	denotes	over
T9624	39534-39537	DT	denotes	the
T9625	39538-39545	NN	denotes	process
T9626	39546-39548	IN	denotes	of
T9627	39549-39561	JJ	denotes	evolutionary
T9628	39562-39566	NN	denotes	time
T9629	39566-39568	,	denotes	,
T9630	39568-39572	IN	denotes	with
T9631	39573-39576	DT	denotes	the
T9632	39577-39588	NN	denotes	acquisition
T9633	39589-39591	IN	denotes	of
T9634	39592-39595	JJ	denotes	new
T9635	39596-39603	NNS	denotes	domains
T9636	39604-39607	CC	denotes	and
T9637	39608-39619	NN	denotes	duplication
T9638	39620-39622	IN	denotes	of
T9639	39623-39626	DT	denotes	the
T9640	39641-39650	NN	denotes	precursor
T9641	39627-39635	NN	denotes	chordate
T9642	39636-39640	NN	denotes	TACC
T9643	39650-39652	,	denotes	,
T9644	39652-39655	DT	denotes	the
T9645	39670-39678	NN	denotes	proteins
T9646	39656-39664	NN	denotes	chordate
T9647	39665-39669	NN	denotes	TACC
T9648	39679-39683	VBP	denotes	have
T9649	39693-39696	DT	denotes	the
T9650	39697-39704	NN	denotes	ability
T9651	39705-39707	TO	denotes	to
T9652	39717-39725	VB	denotes	interact
T9653	39708-39716	RB	denotes	directly
T9654	39726-39730	IN	denotes	with
T9655	39731-39735	DT	denotes	some
T9656	39736-39738	IN	denotes	of
T9657	39739-39742	DT	denotes	the
T9658	39749-39759	NNS	denotes	components
T9659	39743-39748	JJ	denotes	other
T9660	39760-39762	IN	denotes	of
T9661	39763-39768	DT	denotes	these
T9662	39769-39778	NNS	denotes	complexes
T9663	39779-39780	-LRB-	denotes	(
T9664	39780-39784	JJ	denotes	such
T9665	39785-39787	IN	denotes	as
T9666	39788-39791	DT	denotes	the
T9667	39796-39804	NN	denotes	proteins
T9668	39792-39795	NN	denotes	LSm
T9669	39804-39806	,	denotes	,
T9670	39806-39813	JJ	denotes	nuclear
T9671	39822-39831	NNS	denotes	receptors
T9672	39814-39821	NN	denotes	hormone
T9673	39831-39833	,	denotes	,
T9674	39833-39838	NN	denotes	GAS41
T9675	39838-39840	,	denotes	,
T9676	39840-39849	JJ	denotes	accessory
T9677	39850-39858	NN	denotes	proteins
T9678	39859-39862	CC	denotes	and
T9679	39863-39876	NN	denotes	transcription
T9680	39877-39884	NNS	denotes	factors
T9681	39884-39885	-RRB-	denotes	)
T9682	39885-39887	,	denotes	,
T9683	39887-39890	CC	denotes	and
T9684	39891-39895	RB	denotes	thus
T9685	39896-39903	VBD	denotes	evolved
T9686	39904-39914	JJ	denotes	additional
T9687	39915-39924	NNS	denotes	functions
T9688	39925-39931	IN	denotes	within
T9689	39932-39937	DT	denotes	these
T9690	39938-39947	NNS	denotes	complexes
T9691	39947-39948	.	denotes	.
T9692	39948-40156	sentence	denotes	Indeed, the first assigned function of a vertebrate TACC protein, mouse TACC3, was as a transcriptional coactivator of the ARNT mediated transcriptional response to hypoxia and polyaromatic hydrocarbons [7].
T9693	39949-39955	RB	denotes	Indeed
T9694	40028-40031	VBD	denotes	was
T9695	39955-39957	,	denotes	,
T9696	39957-39960	DT	denotes	the
T9697	39976-39984	NN	denotes	function
T9698	39961-39966	JJ	denotes	first
T9699	39967-39975	VBN	denotes	assigned
T9700	39985-39987	IN	denotes	of
T9701	39988-39989	DT	denotes	a
T9702	40006-40013	NN	denotes	protein
T9703	39990-40000	NN	denotes	vertebrate
T9704	40001-40005	NN	denotes	TACC
T9705	40013-40015	,	denotes	,
T9706	40015-40020	NN	denotes	mouse
T9707	40021-40026	NN	denotes	TACC3
T9708	40026-40028	,	denotes	,
T9709	40032-40034	IN	denotes	as
T9710	40035-40036	DT	denotes	a
T9711	40053-40064	NN	denotes	coactivator
T9712	40037-40052	JJ	denotes	transcriptional
T9713	40065-40067	IN	denotes	of
T9714	40068-40071	DT	denotes	the
T9715	40102-40110	NN	denotes	response
T9716	40072-40076	NN	denotes	ARNT
T9717	40077-40085	VBN	denotes	mediated
T9718	40086-40101	JJ	denotes	transcriptional
T9719	40111-40113	IN	denotes	to
T9720	40114-40121	NN	denotes	hypoxia
T9721	40122-40125	CC	denotes	and
T9722	40126-40138	JJ	denotes	polyaromatic
T9723	40139-40151	NNS	denotes	hydrocarbons
T9724	40152-40153	-LRB-	denotes	[
T9725	40153-40154	CD	denotes	7
T9726	40154-40155	-RRB-	denotes	]
T9727	40155-40156	.	denotes	.
T9728	40156-40245	sentence	denotes	Mouse TACC3 has also been reported to interact with the transcription factor STAT5 [33].
T9729	40157-40162	NN	denotes	Mouse
T9730	40163-40168	NN	denotes	TACC3
T9731	40183-40191	VBN	denotes	reported
T9732	40169-40172	VBZ	denotes	has
T9733	40173-40177	RB	denotes	also
T9734	40178-40182	VBN	denotes	been
T9735	40192-40194	TO	denotes	to
T9736	40195-40203	VB	denotes	interact
T9737	40204-40208	IN	denotes	with
T9738	40209-40212	DT	denotes	the
T9739	40234-40239	NN	denotes	STAT5
T9740	40213-40226	NN	denotes	transcription
T9741	40227-40233	NN	denotes	factor
T9742	40240-40241	-LRB-	denotes	[
T9743	40241-40243	CD	denotes	33
T9744	40243-40244	-RRB-	denotes	]
T9745	40244-40245	.	denotes	.
T9746	40245-40462	sentence	denotes	Recently, we have demonstrated that TACC2 and TACC3 can bind to nuclear histone acetyltransferases [34], further confirming a more direct role for the TACC proteins in transcriptional and chromatin remodeling events.
T9747	40246-40254	RB	denotes	Recently
T9748	40264-40276	VBN	denotes	demonstrated
T9749	40254-40256	,	denotes	,
T9750	40256-40258	PRP	denotes	we
T9751	40259-40263	VBP	denotes	have
T9752	40277-40281	IN	denotes	that
T9753	40302-40306	VB	denotes	bind
T9754	40282-40287	NN	denotes	TACC2
T9755	40288-40291	CC	denotes	and
T9756	40292-40297	NN	denotes	TACC3
T9757	40298-40301	MD	denotes	can
T9758	40307-40309	IN	denotes	to
T9759	40310-40317	JJ	denotes	nuclear
T9760	40326-40344	NNS	denotes	acetyltransferases
T9761	40318-40325	NN	denotes	histone
T9762	40345-40346	-LRB-	denotes	[
T9763	40346-40348	CD	denotes	34
T9764	40348-40349	-RRB-	denotes	]
T9765	40349-40351	,	denotes	,
T9766	40351-40358	RB	denotes	further
T9767	40359-40369	VBG	denotes	confirming
T9768	40370-40371	DT	denotes	a
T9769	40384-40388	NN	denotes	role
T9770	40372-40376	RBR	denotes	more
T9771	40377-40383	JJ	denotes	direct
T9772	40389-40392	IN	denotes	for
T9773	40393-40396	DT	denotes	the
T9774	40402-40410	NN	denotes	proteins
T9775	40397-40401	NN	denotes	TACC
T9776	40411-40413	IN	denotes	in
T9777	40414-40429	JJ	denotes	transcriptional
T9778	40455-40461	NNS	denotes	events
T9779	40430-40433	CC	denotes	and
T9780	40434-40443	NN	denotes	chromatin
T9781	40444-40454	NN	denotes	remodeling
T9782	40461-40462	.	denotes	.
T9783	40462-40689	sentence	denotes	Interestingly although all human TACC proteins can directly interact with the histone acetyltransferase pCAF in vitro, the TACC1 isoforms expressed in human breast cancer cells do not interact with this histone acetylase [34].
T9784	40463-40476	RB	denotes	Interestingly
T9785	40647-40655	VB	denotes	interact
T9786	40477-40485	IN	denotes	although
T9787	40523-40531	VB	denotes	interact
T9788	40486-40489	DT	denotes	all
T9789	40501-40509	NN	denotes	proteins
T9790	40490-40495	JJ	denotes	human
T9791	40496-40500	NN	denotes	TACC
T9792	40510-40513	MD	denotes	can
T9793	40514-40522	RB	denotes	directly
T9794	40532-40536	IN	denotes	with
T9795	40537-40540	DT	denotes	the
T9796	40549-40566	NN	denotes	acetyltransferase
T9797	40541-40548	NN	denotes	histone
T9798	40567-40571	NN	denotes	pCAF
T9799	40572-40574	FW	denotes	in
T9800	40575-40580	FW	denotes	vitro
T9801	40580-40582	,	denotes	,
T9802	40582-40585	DT	denotes	the
T9803	40592-40600	NNS	denotes	isoforms
T9804	40586-40591	NN	denotes	TACC1
T9805	40601-40610	VBN	denotes	expressed
T9806	40611-40613	IN	denotes	in
T9807	40614-40619	JJ	denotes	human
T9808	40634-40639	NNS	denotes	cells
T9809	40620-40626	NN	denotes	breast
T9810	40627-40633	NN	denotes	cancer
T9811	40640-40642	VBP	denotes	do
T9812	40643-40646	RB	denotes	not
T9813	40656-40660	IN	denotes	with
T9814	40661-40665	DT	denotes	this
T9815	40674-40683	NN	denotes	acetylase
T9816	40666-40673	NN	denotes	histone
T9817	40684-40685	-LRB-	denotes	[
T9818	40685-40687	CD	denotes	34
T9819	40687-40688	-RRB-	denotes	]
T9820	40688-40689	.	denotes	.
T9821	40689-40843	sentence	denotes	This may be attributable to the proposed function of the Exon 1 containing TACC1 variants in RNA processing, via the interaction with LSm-7 and SmG [19].
T9822	40690-40694	DT	denotes	This
T9823	40699-40701	VB	denotes	be
T9824	40695-40698	MD	denotes	may
T9825	40702-40714	JJ	denotes	attributable
T9826	40715-40717	IN	denotes	to
T9827	40718-40721	DT	denotes	the
T9828	40731-40739	NN	denotes	function
T9829	40722-40730	VBN	denotes	proposed
T9830	40740-40742	IN	denotes	of
T9831	40743-40746	DT	denotes	the
T9832	40771-40779	NNS	denotes	variants
T9833	40747-40751	NN	denotes	Exon
T9834	40754-40764	VBG	denotes	containing
T9835	40752-40753	CD	denotes	1
T9836	40765-40770	NN	denotes	TACC1
T9837	40780-40782	IN	denotes	in
T9838	40783-40786	NN	denotes	RNA
T9839	40787-40797	NN	denotes	processing
T9840	40797-40799	,	denotes	,
T9841	40799-40802	IN	denotes	via
T9842	40803-40806	DT	denotes	the
T9843	40807-40818	NN	denotes	interaction
T9844	40819-40823	IN	denotes	with
T9845	40824-40827	NN	denotes	LSm
T9846	40827-40828	HYPH	denotes	-
T9847	40828-40829	CD	denotes	7
T9848	40830-40833	CC	denotes	and
T9849	40834-40837	NN	denotes	SmG
T9850	40838-40839	-LRB-	denotes	[
T9851	40839-40841	CD	denotes	19
T9852	40841-40842	-RRB-	denotes	]
T9853	40842-40843	.	denotes	.
T9854	40843-41170	sentence	denotes	Thus, alternative splicing of the TACC1 gene adds further diversity to TACC1 function, as the deletion of specific exons and their associated binding domains will change the potential protein complexes with which they can associate, either directly, or by redirecting the splice variants to different subcellular compartments.
T9855	40844-40848	RB	denotes	Thus
T9856	40889-40893	VBZ	denotes	adds
T9857	40848-40850	,	denotes	,
T9858	40850-40861	JJ	denotes	alternative
T9859	40862-40870	NN	denotes	splicing
T9860	40871-40873	IN	denotes	of
T9861	40874-40877	DT	denotes	the
T9862	40884-40888	NN	denotes	gene
T9863	40878-40883	NN	denotes	TACC1
T9864	40894-40901	JJ	denotes	further
T9865	40902-40911	NN	denotes	diversity
T9866	40912-40914	IN	denotes	to
T9867	40915-40920	NN	denotes	TACC1
T9868	40921-40929	NN	denotes	function
T9869	40929-40931	,	denotes	,
T9870	40931-40933	IN	denotes	as
T9871	41007-41013	VB	denotes	change
T9872	40934-40937	DT	denotes	the
T9873	40938-40946	NN	denotes	deletion
T9874	40947-40949	IN	denotes	of
T9875	40950-40958	JJ	denotes	specific
T9876	40959-40964	NNS	denotes	exons
T9877	40965-40968	CC	denotes	and
T9878	40969-40974	PRP$	denotes	their
T9879	40994-41001	NNS	denotes	domains
T9880	40975-40985	VBN	denotes	associated
T9881	40986-40993	NN	denotes	binding
T9882	41002-41006	MD	denotes	will
T9883	41014-41017	DT	denotes	the
T9884	41036-41045	NNS	denotes	complexes
T9885	41018-41027	JJ	denotes	potential
T9886	41028-41035	NN	denotes	protein
T9887	41046-41050	IN	denotes	with
T9888	41066-41075	VB	denotes	associate
T9889	41051-41056	WDT	denotes	which
T9890	41057-41061	PRP	denotes	they
T9891	41062-41065	MD	denotes	can
T9892	41075-41077	,	denotes	,
T9893	41077-41083	CC	denotes	either
T9894	41097-41099	IN	denotes	by
T9895	41084-41092	RB	denotes	directly
T9896	41092-41094	,	denotes	,
T9897	41094-41096	CC	denotes	or
T9898	41100-41111	VBG	denotes	redirecting
T9899	41112-41115	DT	denotes	the
T9900	41123-41131	NNS	denotes	variants
T9901	41116-41122	NN	denotes	splice
T9902	41132-41134	IN	denotes	to
T9903	41135-41144	JJ	denotes	different
T9904	41157-41169	NNS	denotes	compartments
T9905	41145-41156	JJ	denotes	subcellular
T9906	41169-41170	.	denotes	.
T9907	41170-41324	sentence	denotes	With the duplication of the TACC1/TACC2 ancestor, it is apparent that an even greater functional diversity may have been introduced into the TACC family.
T9908	41171-41175	IN	denotes	With
T9909	41224-41226	VBZ	denotes	is
T9910	41176-41179	DT	denotes	the
T9911	41180-41191	NN	denotes	duplication
T9912	41192-41194	IN	denotes	of
T9913	41195-41198	DT	denotes	the
T9914	41211-41219	NN	denotes	ancestor
T9915	41199-41204	NN	denotes	TACC1
T9916	41205-41210	NN	denotes	TACC2
T9917	41204-41205	HYPH	denotes	/
T9918	41219-41221	,	denotes	,
T9919	41221-41223	PRP	denotes	it
T9920	41227-41235	JJ	denotes	apparent
T9921	41236-41240	IN	denotes	that
T9922	41292-41302	VBN	denotes	introduced
T9923	41241-41243	DT	denotes	an
T9924	41268-41277	NN	denotes	diversity
T9925	41244-41248	RB	denotes	even
T9926	41249-41256	JJR	denotes	greater
T9927	41257-41267	JJ	denotes	functional
T9928	41278-41281	MD	denotes	may
T9929	41282-41286	VB	denotes	have
T9930	41287-41291	VBN	denotes	been
T9931	41303-41307	IN	denotes	into
T9932	41308-41311	DT	denotes	the
T9933	41317-41323	NN	denotes	family
T9934	41312-41316	NN	denotes	TACC
T9935	41323-41324	.	denotes	.
T9936	41324-41492	sentence	denotes	The TACC2 protein retains the ability of TACC3 to interact with GAS41, INI1, histone acetyltransferases and transcription factors (in this case, RXRβ) (Fig. 7) [3,34].
T9937	41325-41328	DT	denotes	The
T9938	41335-41342	NN	denotes	protein
T9939	41329-41334	NN	denotes	TACC2
T9940	41343-41350	VBZ	denotes	retains
T9941	41351-41354	DT	denotes	the
T9942	41355-41362	NN	denotes	ability
T9943	41363-41365	IN	denotes	of
T9944	41366-41371	NN	denotes	TACC3
T9945	41372-41374	TO	denotes	to
T9946	41375-41383	VB	denotes	interact
T9947	41384-41388	IN	denotes	with
T9948	41389-41394	NN	denotes	GAS41
T9949	41394-41396	,	denotes	,
T9950	41396-41400	NN	denotes	INI1
T9951	41400-41402	,	denotes	,
T9952	41402-41409	NN	denotes	histone
T9953	41410-41428	NNS	denotes	acetyltransferases
T9954	41429-41432	CC	denotes	and
T9955	41433-41446	NN	denotes	transcription
T9956	41447-41454	NNS	denotes	factors
T9957	41455-41456	-LRB-	denotes	(
T9958	41456-41458	IN	denotes	in
T9959	41470-41474	NN	denotes	RXRβ
T9960	41459-41463	DT	denotes	this
T9961	41464-41468	NN	denotes	case
T9962	41468-41470	,	denotes	,
T9963	41474-41475	-RRB-	denotes	)
T9964	41476-41477	-LRB-	denotes	(
T9965	41477-41481	NN	denotes	Fig.
T9966	41482-41483	CD	denotes	7
T9967	41483-41484	-RRB-	denotes	)
T9968	41485-41486	-LRB-	denotes	[
T9969	41488-41490	CD	denotes	34
T9970	41486-41487	CD	denotes	3
T9971	41487-41488	,	denotes	,
T9972	41490-41491	-RRB-	denotes	]
T9973	41491-41492	.	denotes	.
T9974	41492-41674	sentence	denotes	However, the tissue specific splicing of the 5 kb exon in the TACC2l isoform [3] indicates that this protein has several temporal and tissue specific functions yet to be identified.
T9975	41493-41500	RB	denotes	However
T9976	41574-41583	VBZ	denotes	indicates
T9977	41500-41502	,	denotes	,
T9978	41502-41505	DT	denotes	the
T9979	41522-41530	NN	denotes	splicing
T9980	41506-41512	NN	denotes	tissue
T9981	41513-41521	JJ	denotes	specific
T9982	41531-41533	IN	denotes	of
T9983	41534-41537	DT	denotes	the
T9984	41543-41547	NN	denotes	exon
T9985	41538-41539	CD	denotes	5
T9986	41540-41542	NN	denotes	kb
T9987	41548-41550	IN	denotes	in
T9988	41551-41554	DT	denotes	the
T9989	41562-41569	NN	denotes	isoform
T9990	41555-41561	NN	denotes	TACC2l
T9991	41570-41571	-LRB-	denotes	[
T9992	41571-41572	CD	denotes	3
T9993	41572-41573	-RRB-	denotes	]
T9994	41584-41588	IN	denotes	that
T9995	41602-41605	VBZ	denotes	has
T9996	41589-41593	DT	denotes	this
T9997	41594-41601	NN	denotes	protein
T9998	41606-41613	JJ	denotes	several
T9999	41643-41652	NNS	denotes	functions
T10000	41614-41622	JJ	denotes	temporal
T10001	41623-41626	CC	denotes	and
T10002	41627-41633	NN	denotes	tissue
T10003	41634-41642	JJ	denotes	specific
T10004	41653-41656	RB	denotes	yet
T10005	41663-41673	VBN	denotes	identified
T10006	41657-41659	TO	denotes	to
T10007	41660-41662	VB	denotes	be
T10008	41673-41674	.	denotes	.
T13816	32821-32823	IN	denotes	In
T10098	41685-41696	NN	denotes	Compilation
T10099	41697-41700	CC	denotes	and
T10100	41701-41709	NN	denotes	assembly
T10101	41710-41712	IN	denotes	of
T10102	41713-41723	RB	denotes	previously
T10103	41724-41739	JJ	denotes	uncharacterized
T10104	41745-41750	NNS	denotes	cDNAs
T10105	41740-41744	NN	denotes	TACC
T10106	41751-41754	CC	denotes	and
T10107	41755-41760	NNS	denotes	genes
T10108	41760-41958	sentence	denotes	Corresponding orthologous sequences for TACC, RHAMM, KLP, KIF, TPM and keratins families were identified initially using the TBLASTN program [36] to search the published genomic and cDNA databases.
T10109	41761-41774	VBG	denotes	Corresponding
T10110	41787-41796	NNS	denotes	sequences
T10111	41775-41786	JJ	denotes	orthologous
T10112	41855-41865	VBN	denotes	identified
T10113	41797-41800	IN	denotes	for
T10114	41801-41805	NN	denotes	TACC
T10115	41841-41849	NNS	denotes	families
T10116	41805-41807	,	denotes	,
T10117	41807-41812	NN	denotes	RHAMM
T10118	41812-41814	,	denotes	,
T10119	41814-41817	NN	denotes	KLP
T10120	41817-41819	,	denotes	,
T10121	41819-41822	NN	denotes	KIF
T10122	41822-41824	,	denotes	,
T10123	41824-41827	NN	denotes	TPM
T10124	41828-41831	CC	denotes	and
T10125	41832-41840	NNS	denotes	keratins
T10126	41850-41854	VBD	denotes	were
T10127	41866-41875	RB	denotes	initially
T10128	41876-41881	VBG	denotes	using
T10129	41882-41885	DT	denotes	the
T10130	41894-41901	NN	denotes	program
T10131	41886-41893	NNP	denotes	TBLASTN
T10132	41902-41903	-LRB-	denotes	[
T10133	41903-41905	CD	denotes	36
T10134	41905-41906	-RRB-	denotes	]
T10135	41907-41909	TO	denotes	to
T10136	41910-41916	VB	denotes	search
T10137	41917-41920	DT	denotes	the
T10138	41948-41957	NNS	denotes	databases
T10139	41921-41930	VBN	denotes	published
T10140	41931-41938	JJ	denotes	genomic
T10141	41939-41942	CC	denotes	and
T10142	41943-41947	NN	denotes	cDNA
T10143	41957-41958	.	denotes	.
T10144	41958-42078	sentence	denotes	For Takifugu rubripes, gene predictions were produced by the Ensembl automated pipeline [37] and the JGI blast server .
T10145	41959-41962	IN	denotes	For
T10146	42004-42012	VBN	denotes	produced
T10147	41963-41971	NNP	denotes	Takifugu
T10148	41972-41980	NNP	denotes	rubripes
T10149	41980-41982	,	denotes	,
T10150	41982-41986	NN	denotes	gene
T10151	41987-41998	NNS	denotes	predictions
T10152	41999-42003	VBD	denotes	were
T10153	42013-42015	IN	denotes	by
T10154	42016-42019	DT	denotes	the
T10155	42038-42046	NN	denotes	pipeline
T10156	42020-42027	NNP	denotes	Ensembl
T10157	42028-42037	VBN	denotes	automated
T10158	42047-42048	-LRB-	denotes	[
T10159	42048-42050	CD	denotes	37
T10160	42050-42051	-RRB-	denotes	]
T10161	42052-42055	CC	denotes	and
T10162	42056-42059	DT	denotes	the
T10163	42070-42076	NN	denotes	server
T10164	42060-42063	NN	denotes	JGI
T10165	42064-42069	NN	denotes	blast
T10166	42077-42078	.	denotes	.
T10167	42078-42188	sentence	denotes	DNA sequences covering the homology regions were extracted and analyzed by Genscan to obtain potential exons.
T10168	42079-42082	NN	denotes	DNA
T10169	42083-42092	NNS	denotes	sequences
T10170	42128-42137	VBN	denotes	extracted
T10171	42093-42101	VBG	denotes	covering
T10172	42102-42105	DT	denotes	the
T10173	42115-42122	NNS	denotes	regions
T10174	42106-42114	NN	denotes	homology
T10175	42123-42127	VBD	denotes	were
T10176	42138-42141	CC	denotes	and
T10177	42142-42150	VBN	denotes	analyzed
T10178	42151-42153	IN	denotes	by
T10179	42154-42161	NNP	denotes	Genscan
T10180	42162-42164	TO	denotes	to
T10181	42165-42171	VB	denotes	obtain
T10182	42172-42181	JJ	denotes	potential
T10183	42182-42187	NNS	denotes	exons
T10184	42187-42188	.	denotes	.
T10185	42188-42331	sentence	denotes	In some cases, exons were added or modified based on the best similarity of translated peptides to the corresponding mouse and human proteins.
T10186	42189-42191	IN	denotes	In
T10187	42215-42220	VBN	denotes	added
T10188	42192-42196	DT	denotes	some
T10189	42197-42202	NNS	denotes	cases
T10190	42202-42204	,	denotes	,
T10191	42204-42209	NNS	denotes	exons
T10192	42210-42214	VBD	denotes	were
T10193	42221-42223	CC	denotes	or
T10194	42224-42232	VBN	denotes	modified
T10195	42233-42238	VBN	denotes	based
T10196	42239-42241	IN	denotes	on
T10197	42242-42245	DT	denotes	the
T10198	42251-42261	NN	denotes	similarity
T10199	42246-42250	JJS	denotes	best
T10200	42262-42264	IN	denotes	of
T10201	42265-42275	VBN	denotes	translated
T10202	42276-42284	NNS	denotes	peptides
T10203	42285-42287	IN	denotes	to
T10204	42288-42291	DT	denotes	the
T10205	42322-42330	NN	denotes	proteins
T10206	42292-42305	VBG	denotes	corresponding
T10207	42306-42311	NN	denotes	mouse
T10208	42312-42315	CC	denotes	and
T10209	42316-42321	JJ	denotes	human
T10210	42330-42331	.	denotes	.
T10211	42331-42509	sentence	denotes	For regions with low sequence similarity, genomic sequences from the fresh water pufferfish, Tetraodon nigroviridis were used as additional means to verify the predicted exons.
T10212	42332-42335	IN	denotes	For
T10213	42454-42458	VBN	denotes	used
T10214	42336-42343	NNS	denotes	regions
T10215	42344-42348	IN	denotes	with
T10216	42349-42352	JJ	denotes	low
T10217	42362-42372	NN	denotes	similarity
T10218	42353-42361	NN	denotes	sequence
T10219	42372-42374	,	denotes	,
T10220	42374-42381	JJ	denotes	genomic
T10221	42382-42391	NNS	denotes	sequences
T10222	42393-42397	IN	denotes	from
T10223	42398-42401	DT	denotes	the
T10224	42414-42424	NN	denotes	pufferfish
T10225	42402-42407	JJ	denotes	fresh
T10226	42408-42413	NN	denotes	water
T10227	42424-42426	,	denotes	,
T10228	42426-42435	NNP	denotes	Tetraodon
T10229	42436-42448	NNP	denotes	nigroviridis
T10230	42449-42453	VBD	denotes	were
T10231	42459-42461	IN	denotes	as
T10232	42462-42472	JJ	denotes	additional
T10233	42473-42478	NNS	denotes	means
T10234	42479-42481	TO	denotes	to
T10235	42482-42488	VB	denotes	verify
T10236	42489-42492	DT	denotes	the
T10237	42503-42508	NNS	denotes	exons
T10238	42493-42502	VBN	denotes	predicted
T10239	42508-42509	.	denotes	.
T10240	42509-42809	sentence	denotes	Due to the variability of the central region of vertebrate TACC3 cDNAs (see text), to further confirm prediction of the Takifugu rubripes TACC3, full length cDNAs corresponding to the Danio rerio TACC3 (IMAGE clones 2639991, 2640369 and 3724452) were also obtained from A.T.C.C. and fully sequenced.
T10241	42510-42513	IN	denotes	Due
T10242	42766-42774	VBN	denotes	obtained
T10243	42514-42516	IN	denotes	to
T10244	42517-42520	DT	denotes	the
T10245	42521-42532	NN	denotes	variability
T10246	42533-42535	IN	denotes	of
T10247	42536-42539	DT	denotes	the
T10248	42548-42554	NN	denotes	region
T10249	42540-42547	JJ	denotes	central
T10250	42555-42557	IN	denotes	of
T10251	42558-42568	NN	denotes	vertebrate
T10252	42575-42580	NNS	denotes	cDNAs
T10253	42569-42574	NN	denotes	TACC3
T10254	42581-42582	-LRB-	denotes	(
T10255	42582-42585	VB	denotes	see
T10256	42586-42590	NN	denotes	text
T10257	42590-42591	-RRB-	denotes	)
T10258	42591-42593	,	denotes	,
T10259	42593-42595	TO	denotes	to
T10260	42604-42611	VB	denotes	confirm
T10261	42596-42603	RB	denotes	further
T10262	42612-42622	NN	denotes	prediction
T10263	42623-42625	IN	denotes	of
T10264	42626-42629	DT	denotes	the
T10265	42639-42647	NNP	denotes	rubripes
T10266	42630-42638	NNP	denotes	Takifugu
T10267	42648-42653	NN	denotes	TACC3
T10268	42653-42655	,	denotes	,
T10269	42655-42659	JJ	denotes	full
T10270	42660-42666	NN	denotes	length
T10271	42667-42672	NNS	denotes	cDNAs
T10272	42673-42686	VBG	denotes	corresponding
T10273	42687-42689	IN	denotes	to
T10274	42690-42693	DT	denotes	the
T10275	42706-42711	NN	denotes	TACC3
T10276	42694-42699	NNP	denotes	Danio
T10277	42700-42705	NNP	denotes	rerio
T10278	42712-42713	-LRB-	denotes	(
T10279	42726-42733	CD	denotes	2639991
T10280	42713-42718	NN	denotes	IMAGE
T10281	42719-42725	NNS	denotes	clones
T10282	42733-42735	,	denotes	,
T10283	42735-42742	CD	denotes	2640369
T10284	42743-42746	CC	denotes	and
T10285	42747-42754	CD	denotes	3724452
T10286	42754-42755	-RRB-	denotes	)
T10287	42756-42760	VBD	denotes	were
T10288	42761-42765	RB	denotes	also
T10289	42775-42779	IN	denotes	from
T10290	42780-42788	NN	denotes	A.T.C.C.
T10291	42789-42792	CC	denotes	and
T10292	42793-42798	RB	denotes	fully
T10293	42799-42808	VBN	denotes	sequenced
T10294	42808-42809	.	denotes	.
T10295	42809-42987	sentence	denotes	Potential paralogous chromosomal segments and scaffold were identified by searching the public databases deposited at NCBI and at the Human Genome Mapping Project, Cambridge UK.
T10296	42810-42819	JJ	denotes	Potential
T10297	42843-42851	NNS	denotes	segments
T10298	42820-42830	JJ	denotes	paralogous
T10299	42831-42842	JJ	denotes	chromosomal
T10300	42870-42880	VBN	denotes	identified
T10301	42852-42855	CC	denotes	and
T10302	42856-42864	NN	denotes	scaffold
T10303	42865-42869	VBD	denotes	were
T10304	42881-42883	IN	denotes	by
T10305	42884-42893	VBG	denotes	searching
T10306	42894-42897	DT	denotes	the
T10307	42905-42914	NNS	denotes	databases
T10308	42898-42904	JJ	denotes	public
T10309	42915-42924	VBN	denotes	deposited
T10310	42925-42927	IN	denotes	at
T10311	42928-42932	NNP	denotes	NCBI
T10312	42933-42936	CC	denotes	and
T10313	42937-42939	IN	denotes	at
T10314	42940-42943	DT	denotes	the
T10315	42965-42972	NNP	denotes	Project
T10316	42944-42949	NNP	denotes	Human
T10317	42950-42956	NNP	denotes	Genome
T10318	42957-42964	NNP	denotes	Mapping
T10319	42972-42974	,	denotes	,
T10320	42974-42983	NNP	denotes	Cambridge
T10321	42984-42986	NNP	denotes	UK
T10322	42986-42987	.	denotes	.
T13817	32840-32847	VBZ	denotes	denotes
T10440	42997-42999	IN	denotes	of
T10441	43000-43010	NN	denotes	vertebrate
T10442	43011-43015	NN	denotes	TACC
T10443	43016-43021	NNS	denotes	cDNAs
T10444	43021-43286	sentence	denotes	The rabbit TACC3 was cloned by rt-PCR using the "TACC4" specific primer T4RACE2 [9] (5'-cccgaactgctccaggtaatcgatctc-3') and a consensus primer, T3con2, designed to the region encompassing the vertebrate TACC3 initiator methionine (5'-tatgagtctgcaggtcttaaacgac-3').
T10445	43022-43025	DT	denotes	The
T10446	43033-43038	NN	denotes	TACC3
T10447	43026-43032	NN	denotes	rabbit
T10448	43043-43049	VBN	denotes	cloned
T10449	43039-43042	VBD	denotes	was
T10450	43050-43052	IN	denotes	by
T10451	43053-43055	NN	denotes	rt
T10452	43056-43059	NN	denotes	PCR
T10453	43055-43056	HYPH	denotes	-
T10454	43060-43065	VBG	denotes	using
T10455	43066-43069	DT	denotes	the
T10456	43087-43093	NN	denotes	primer
T10457	43070-43071	``	denotes	"
T10458	43078-43086	JJ	denotes	specific
T10459	43071-43076	NN	denotes	TACC4
T10460	43076-43077	''	denotes	"
T10461	43094-43101	NN	denotes	T4RACE2
T10462	43102-43103	-LRB-	denotes	[
T10463	43103-43104	CD	denotes	9
T10464	43104-43105	-RRB-	denotes	]
T10465	43106-43107	-LRB-	denotes	(
T10466	43110-43137	NN	denotes	cccgaactgctccaggtaatcgatctc
T10467	43107-43108	CD	denotes	5
T10468	43108-43109	SYM	denotes	'
T10469	43109-43110	HYPH	denotes	-
T10470	43137-43138	HYPH	denotes	-
T10471	43138-43139	CD	denotes	3
T10472	43139-43140	SYM	denotes	'
T10473	43140-43141	-RRB-	denotes	)
T10474	43142-43145	CC	denotes	and
T10475	43146-43147	DT	denotes	a
T10476	43158-43164	NN	denotes	primer
T10477	43148-43157	NN	denotes	consensus
T10478	43164-43166	,	denotes	,
T10479	43166-43172	NN	denotes	T3con2
T10480	43172-43174	,	denotes	,
T10481	43174-43182	VBN	denotes	designed
T10482	43183-43185	IN	denotes	to
T10483	43186-43189	DT	denotes	the
T10484	43190-43196	NN	denotes	region
T10485	43197-43209	VBG	denotes	encompassing
T10486	43210-43213	DT	denotes	the
T10487	43231-43240	NN	denotes	initiator
T10488	43214-43224	NN	denotes	vertebrate
T10489	43225-43230	NN	denotes	TACC3
T10490	43241-43251	NN	denotes	methionine
T10491	43252-43253	-LRB-	denotes	(
T10492	43256-43281	NN	denotes	tatgagtctgcaggtcttaaacgac
T10493	43253-43254	CD	denotes	5
T10494	43254-43255	SYM	denotes	'
T10495	43255-43256	HYPH	denotes	-
T10496	43281-43282	HYPH	denotes	-
T10497	43282-43283	CD	denotes	3
T10498	43283-43284	SYM	denotes	'
T10499	43284-43285	-RRB-	denotes	)
T10500	43285-43286	.	denotes	.
T10501	43286-43672	sentence	denotes	For cloning the mouse Tacc1X cDNA, the primers used were based upon the genomic sequence reported, and the sequence of the IMAGE cDNA clone 4933429K08: T1XF (5'-ccatgttcagtcattggcaggtc-3'), T1XF2 (5'-ctgcagaaccaacagttcaag-3'), T1XR1 (5'-agatctgtgacatcacagctc-3'), T1XR2 (5'-ctcgagtcagttagtcttatccagctt-3'), BB617F (5'-accaccaacttgagtacctg-3') and BB617R (5'-gtatcttgaactgttggttctg-3').
T10502	43287-43290	IN	denotes	For
T10503	43344-43349	VBN	denotes	based
T10504	43291-43298	VBG	denotes	cloning
T10505	43299-43302	DT	denotes	the
T10506	43316-43320	NN	denotes	cDNA
T10507	43303-43308	NN	denotes	mouse
T10508	43309-43315	NN	denotes	Tacc1X
T10509	43320-43322	,	denotes	,
T10510	43322-43325	DT	denotes	the
T10511	43326-43333	NNS	denotes	primers
T10512	43334-43338	VBN	denotes	used
T10513	43339-43343	VBD	denotes	were
T10514	43350-43354	IN	denotes	upon
T10515	43355-43358	DT	denotes	the
T10516	43367-43375	NN	denotes	sequence
T10517	43359-43366	JJ	denotes	genomic
T10518	43376-43384	VBN	denotes	reported
T10519	43384-43386	,	denotes	,
T10520	43386-43389	CC	denotes	and
T10521	43390-43393	DT	denotes	the
T10522	43394-43402	NN	denotes	sequence
T10523	43403-43405	IN	denotes	of
T10524	43406-43409	DT	denotes	the
T10525	43421-43426	NN	denotes	clone
T10526	43410-43415	NN	denotes	IMAGE
T10527	43416-43420	NN	denotes	cDNA
T10528	43427-43437	NN	denotes	4933429K08
T10529	43437-43439	:	denotes	:
T10530	43439-43443	NN	denotes	T1XF
T10531	43444-43445	-LRB-	denotes	(
T10532	43448-43471	NN	denotes	ccatgttcagtcattggcaggtc
T10533	43445-43446	CD	denotes	5
T10534	43446-43447	SYM	denotes	'
T10535	43447-43448	HYPH	denotes	-
T10536	43471-43472	HYPH	denotes	-
T10537	43472-43473	CD	denotes	3
T10538	43473-43474	SYM	denotes	'
T10539	43474-43475	-RRB-	denotes	)
T10540	43475-43477	,	denotes	,
T10541	43477-43482	NN	denotes	T1XF2
T10542	43483-43484	-LRB-	denotes	(
T10543	43487-43508	NN	denotes	ctgcagaaccaacagttcaag
T10544	43484-43485	CD	denotes	5
T10545	43485-43486	SYM	denotes	'
T10546	43486-43487	HYPH	denotes	-
T10547	43508-43509	HYPH	denotes	-
T10548	43509-43510	CD	denotes	3
T10549	43510-43511	SYM	denotes	'
T10550	43511-43512	-RRB-	denotes	)
T10551	43512-43514	,	denotes	,
T10552	43514-43519	NN	denotes	T1XR1
T10553	43520-43521	-LRB-	denotes	(
T10554	43524-43545	NN	denotes	agatctgtgacatcacagctc
T10555	43521-43522	CD	denotes	5
T10556	43522-43523	SYM	denotes	'
T10557	43523-43524	HYPH	denotes	-
T10558	43545-43546	HYPH	denotes	-
T10559	43546-43547	CD	denotes	3
T10560	43547-43548	SYM	denotes	'
T10561	43548-43549	-RRB-	denotes	)
T10562	43549-43551	,	denotes	,
T10563	43551-43556	NN	denotes	T1XR2
T10564	43557-43558	-LRB-	denotes	(
T10565	43561-43588	NN	denotes	ctcgagtcagttagtcttatccagctt
T10566	43558-43559	CD	denotes	5
T10567	43559-43560	SYM	denotes	'
T10568	43560-43561	HYPH	denotes	-
T10569	43588-43589	HYPH	denotes	-
T10570	43589-43590	CD	denotes	3
T10571	43590-43591	SYM	denotes	'
T10572	43591-43592	-RRB-	denotes	)
T10573	43592-43594	,	denotes	,
T10574	43594-43600	NN	denotes	BB617F
T10575	43601-43602	-LRB-	denotes	(
T10576	43605-43625	NN	denotes	accaccaacttgagtacctg
T10577	43602-43603	CD	denotes	5
T10578	43603-43604	SYM	denotes	'
T10579	43604-43605	HYPH	denotes	-
T10580	43625-43626	HYPH	denotes	-
T10581	43626-43627	CD	denotes	3
T10582	43627-43628	SYM	denotes	'
T10583	43628-43629	-RRB-	denotes	)
T10584	43630-43633	CC	denotes	and
T10585	43634-43640	NN	denotes	BB617R
T10586	43641-43642	-LRB-	denotes	(
T10587	43645-43667	NN	denotes	gtatcttgaactgttggttctg
T10588	43642-43643	CD	denotes	5
T10589	43643-43644	SYM	denotes	'
T10590	43644-43645	HYPH	denotes	-
T10591	43667-43668	HYPH	denotes	-
T10592	43668-43669	CD	denotes	3
T10593	43669-43670	SYM	denotes	'
T10594	43670-43671	-RRB-	denotes	)
T10595	43671-43672	.	denotes	.
T10596	43672-43879	sentence	denotes	For analysis of TACC1 splice variants, the forward primers used were located in exon 1b: EF (5'-gagagatgcgaaatcagcg-3'), Exon 1d: X3F (5'-agtcaaagaaggcatctgcag-3'), Exon 1a: 1DF (5'-ccaagttctgcgccatggg-3').
T10597	43673-43676	IN	denotes	For
T10598	43742-43749	VBN	denotes	located
T10599	43677-43685	NN	denotes	analysis
T10600	43686-43688	IN	denotes	of
T10601	43689-43694	NN	denotes	TACC1
T10602	43702-43710	NNS	denotes	variants
T10603	43695-43701	NN	denotes	splice
T10604	43710-43712	,	denotes	,
T10605	43712-43715	DT	denotes	the
T10606	43724-43731	NNS	denotes	primers
T10607	43716-43723	JJ	denotes	forward
T10608	43732-43736	VBN	denotes	used
T10609	43737-43741	VBD	denotes	were
T10610	43750-43752	IN	denotes	in
T10611	43753-43757	NN	denotes	exon
T10612	43758-43760	CD	denotes	1b
T10613	43760-43762	:	denotes	:
T10614	43762-43764	NN	denotes	EF
T10615	43769-43788	NN	denotes	gagagatgcgaaatcagcg
T10616	43765-43766	-LRB-	denotes	(
T10617	43766-43767	CD	denotes	5
T10618	43767-43768	SYM	denotes	'
T10619	43768-43769	HYPH	denotes	-
T10620	43788-43789	HYPH	denotes	-
T10621	43789-43790	CD	denotes	3
T10622	43790-43791	SYM	denotes	'
T10623	43791-43792	-RRB-	denotes	)
T10624	43792-43794	,	denotes	,
T10625	43794-43798	NN	denotes	Exon
T10626	43799-43801	CD	denotes	1d
T10627	43801-43803	:	denotes	:
T10628	43803-43806	NN	denotes	X3F
T10629	43811-43832	NN	denotes	agtcaaagaaggcatctgcag
T10630	43807-43808	-LRB-	denotes	(
T10631	43808-43809	CD	denotes	5
T10632	43809-43810	SYM	denotes	'
T10633	43810-43811	HYPH	denotes	-
T10634	43832-43833	HYPH	denotes	-
T10635	43833-43834	CD	denotes	3
T10636	43834-43835	SYM	denotes	'
T10637	43835-43836	-RRB-	denotes	)
T10638	43836-43838	,	denotes	,
T10639	43838-43842	NN	denotes	Exon
T10640	43843-43845	CD	denotes	1a
T10641	43845-43847	:	denotes	:
T10642	43847-43850	NN	denotes	1DF
T10643	43855-43874	NN	denotes	ccaagttctgcgccatggg
T10644	43851-43852	-LRB-	denotes	(
T10645	43852-43853	CD	denotes	5
T10646	43853-43854	SYM	denotes	'
T10647	43854-43855	HYPH	denotes	-
T10648	43874-43875	HYPH	denotes	-
T10649	43875-43876	CD	denotes	3
T10650	43876-43877	SYM	denotes	'
T10651	43877-43878	-RRB-	denotes	)
T10652	43878-43879	.	denotes	.
T10653	43879-44138	sentence	denotes	The reverse primers used were: Exon 1: X1R (5'-ggatttggtctcggcttgcgaatc-3'), Exon 2: BX647R (5'-cttgtgattcttggcttttgg-3'), Exon 3: 6SPR (5'-gtcatcgcctcgtcctggagggc-3'), Exon 4a: 1DR (5'-aatttcacttgttcagtagtc-3'), Exon 5: 128R (5'-cctgcttctgaggatgaaaacgc-3').
T10654	43880-43883	DT	denotes	The
T10655	43892-43899	NNS	denotes	primers
T10656	43884-43891	JJ	denotes	reverse
T10657	43905-43909	VBD	denotes	were
T10658	43900-43904	VBN	denotes	used
T10659	43909-43911	:	denotes	:
T10660	43911-43915	NN	denotes	Exon
T10661	43916-43917	CD	denotes	1
T10662	43917-43919	:	denotes	:
T10663	43919-43922	NN	denotes	X1R
T10664	43927-43951	NN	denotes	ggatttggtctcggcttgcgaatc
T10665	43923-43924	-LRB-	denotes	(
T10666	43924-43925	CD	denotes	5
T10667	43925-43926	SYM	denotes	'
T10668	43926-43927	HYPH	denotes	-
T10669	43951-43952	HYPH	denotes	-
T10670	43952-43953	CD	denotes	3
T10671	43953-43954	SYM	denotes	'
T10672	43954-43955	-RRB-	denotes	)
T10673	43955-43957	,	denotes	,
T10674	43957-43961	NN	denotes	Exon
T10675	43962-43963	CD	denotes	2
T10676	43963-43965	:	denotes	:
T10677	43965-43971	NN	denotes	BX647R
T10678	43976-43997	NN	denotes	cttgtgattcttggcttttgg
T10679	43972-43973	-LRB-	denotes	(
T10680	43973-43974	CD	denotes	5
T10681	43974-43975	SYM	denotes	'
T10682	43975-43976	HYPH	denotes	-
T10683	43997-43998	HYPH	denotes	-
T10684	43998-43999	CD	denotes	3
T10685	43999-44000	SYM	denotes	'
T10686	44000-44001	-RRB-	denotes	)
T10687	44001-44003	,	denotes	,
T10688	44003-44007	NN	denotes	Exon
T10689	44008-44009	CD	denotes	3
T10690	44009-44011	:	denotes	:
T10691	44011-44015	NN	denotes	6SPR
T10692	44020-44043	NN	denotes	gtcatcgcctcgtcctggagggc
T10693	44016-44017	-LRB-	denotes	(
T10694	44017-44018	CD	denotes	5
T10695	44018-44019	SYM	denotes	'
T10696	44019-44020	HYPH	denotes	-
T10697	44043-44044	HYPH	denotes	-
T10698	44044-44045	CD	denotes	3
T10699	44045-44046	SYM	denotes	'
T10700	44046-44047	-RRB-	denotes	)
T10701	44047-44049	,	denotes	,
T10702	44049-44053	NN	denotes	Exon
T10703	44054-44056	NN	denotes	4a
T10704	44056-44058	:	denotes	:
T10705	44058-44061	NN	denotes	1DR
T10706	44066-44087	NN	denotes	aatttcacttgttcagtagtc
T10707	44062-44063	-LRB-	denotes	(
T10708	44063-44064	CD	denotes	5
T10709	44064-44065	SYM	denotes	'
T10710	44065-44066	HYPH	denotes	-
T10711	44087-44088	HYPH	denotes	-
T10712	44088-44089	CD	denotes	3
T10713	44089-44090	SYM	denotes	'
T10714	44090-44091	-RRB-	denotes	)
T10715	44091-44093	,	denotes	,
T10716	44093-44097	NN	denotes	Exon
T10717	44098-44099	CD	denotes	5
T10718	44099-44101	:	denotes	:
T10719	44101-44105	NN	denotes	128R
T10720	44110-44133	NN	denotes	cctgcttctgaggatgaaaacgc
T10721	44106-44107	-LRB-	denotes	(
T10722	44107-44108	CD	denotes	5
T10723	44108-44109	SYM	denotes	'
T10724	44109-44110	HYPH	denotes	-
T10725	44133-44134	HYPH	denotes	-
T10726	44134-44135	CD	denotes	3
T10727	44135-44136	SYM	denotes	'
T10728	44136-44137	-RRB-	denotes	)
T10729	44137-44138	.	denotes	.
T10730	44138-44271	sentence	denotes	Rabbit brain poly A+ mRNA, mouse testis and human brain total RNA were obtained from BD Bioscience Clontech (Palo Alto, CA, U.S.A.).
T10731	44139-44145	NN	denotes	Rabbit
T10732	44146-44151	NN	denotes	brain
T10733	44160-44164	NN	denotes	mRNA
T10734	44152-44156	NN	denotes	poly
T10735	44157-44159	NN	denotes	A+
T10736	44210-44218	VBN	denotes	obtained
T10737	44164-44166	,	denotes	,
T10738	44166-44171	NN	denotes	mouse
T10739	44172-44178	NN	denotes	testis
T10740	44179-44182	CC	denotes	and
T10741	44183-44188	JJ	denotes	human
T10742	44189-44194	NN	denotes	brain
T10743	44201-44204	NN	denotes	RNA
T10744	44195-44200	JJ	denotes	total
T10745	44205-44209	VBD	denotes	were
T10746	44219-44223	IN	denotes	from
T10747	44224-44226	NNP	denotes	BD
T10748	44238-44246	NNP	denotes	Clontech
T10749	44227-44237	NNP	denotes	Bioscience
T10750	44247-44248	-LRB-	denotes	(
T10751	44248-44252	NNP	denotes	Palo
T10752	44253-44257	NNP	denotes	Alto
T10753	44257-44259	,	denotes	,
T10754	44259-44261	NNP	denotes	CA
T10755	44261-44263	,	denotes	,
T10756	44263-44269	NNP	denotes	U.S.A.
T10757	44269-44270	-RRB-	denotes	)
T10758	44270-44271	.	denotes	.
T10759	44271-44441	sentence	denotes	Reverse transcription and PCR was performed as previously described, using either 1 μg of total RNA or 50 ng of poly A+ mRNA as template for first strand cDNA synthesis.
T10760	44272-44279	JJ	denotes	Reverse
T10761	44280-44293	NN	denotes	transcription
T10762	44306-44315	VBN	denotes	performed
T10763	44294-44297	CC	denotes	and
T10764	44298-44301	NN	denotes	PCR
T10765	44302-44305	VBD	denotes	was
T10766	44316-44318	IN	denotes	as
T10767	44330-44339	VBN	denotes	described
T10768	44319-44329	RB	denotes	previously
T10769	44339-44341	,	denotes	,
T10770	44341-44346	VBG	denotes	using
T10771	44347-44353	CC	denotes	either
T10772	44356-44358	NN	denotes	μg
T10773	44354-44355	CD	denotes	1
T10774	44359-44361	IN	denotes	of
T10775	44362-44367	JJ	denotes	total
T10776	44368-44371	NN	denotes	RNA
T10777	44372-44374	CC	denotes	or
T10778	44375-44377	CD	denotes	50
T10779	44378-44380	NNS	denotes	ng
T10780	44381-44383	IN	denotes	of
T10781	44384-44388	NN	denotes	poly
T10782	44389-44391	NN	denotes	A+
T10783	44392-44396	NN	denotes	mRNA
T10784	44397-44399	IN	denotes	as
T10785	44400-44408	NN	denotes	template
T10786	44409-44412	IN	denotes	for
T10787	44413-44418	JJ	denotes	first
T10788	44419-44425	NN	denotes	strand
T10789	44426-44430	NN	denotes	cDNA
T10790	44431-44440	NN	denotes	synthesis
T10791	44440-44441	.	denotes	.
T10792	44441-44557	sentence	denotes	PCR products were cloned into pCR2.1 (Invitrogen, Carlsbad CA, U.S.A.) and transformed into InvαF' competent cells.
T10793	44442-44445	NN	denotes	PCR
T10794	44446-44454	NNS	denotes	products
T10795	44460-44466	VBN	denotes	cloned
T10796	44455-44459	VBD	denotes	were
T10797	44467-44471	IN	denotes	into
T10798	44472-44478	NN	denotes	pCR2.1
T10799	44479-44480	-LRB-	denotes	(
T10800	44480-44490	NNP	denotes	Invitrogen
T10801	44490-44492	,	denotes	,
T10802	44492-44500	NNP	denotes	Carlsbad
T10803	44501-44503	NNP	denotes	CA
T10804	44503-44505	,	denotes	,
T10805	44505-44511	NNP	denotes	U.S.A.
T10806	44511-44512	-RRB-	denotes	)
T10807	44513-44516	CC	denotes	and
T10808	44517-44528	VBN	denotes	transformed
T10809	44529-44533	IN	denotes	into
T10810	44534-44539	NN	denotes	InvαF
T10811	44541-44550	JJ	denotes	competent
T10812	44539-44540	POS	denotes	'
T10813	44551-44556	NNS	denotes	cells
T10814	44556-44557	.	denotes	.
T10815	44557-44651	sentence	denotes	Plasmid inserts were sequenced by the Roswell Park Cancer Institute Biopolymer Core Facility.
T10816	44558-44565	NN	denotes	Plasmid
T10817	44566-44573	NNS	denotes	inserts
T10818	44579-44588	VBN	denotes	sequenced
T10819	44574-44578	VBD	denotes	were
T10820	44589-44591	IN	denotes	by
T10821	44592-44595	DT	denotes	the
T10822	44642-44650	NNP	denotes	Facility
T10823	44596-44603	NNP	denotes	Roswell
T10824	44604-44608	NNP	denotes	Park
T10825	44616-44625	NNP	denotes	Institute
T10826	44609-44615	NNP	denotes	Cancer
T10827	44626-44636	NNP	denotes	Biopolymer
T10828	44637-44641	NNP	denotes	Core
T10829	44650-44651	.	denotes	.
T10982	44653-44663	NN	denotes	Deposition
T10983	44664-44666	IN	denotes	of
T10984	44667-44677	NN	denotes	nucleotide
T10985	44678-44687	NNS	denotes	sequences
T10986	44687-45039	sentence	denotes	Sequences from this article have been deposited in the GenBank database with the following accession numbers: Homo sapiens TACC1 short isoform S (AY177411), Mus musculus TACC1 short isoform S (AY177412), Mus musculus TACC1 long isoform A (AY177413), Mus musculus TACC2s (AY177410), Oryctolagus cuniculus TACC3 (AY161270), Danio rerio TACC3 (AY170618).
T10987	44688-44697	NNS	denotes	Sequences
T10988	44726-44735	VBN	denotes	deposited
T10989	44698-44702	IN	denotes	from
T10990	44703-44707	DT	denotes	this
T10991	44708-44715	NN	denotes	article
T10992	44716-44720	VBP	denotes	have
T10993	44721-44725	VBN	denotes	been
T10994	44736-44738	IN	denotes	in
T10995	44739-44742	DT	denotes	the
T10996	44751-44759	NN	denotes	database
T10997	44743-44750	NNP	denotes	GenBank
T10998	44760-44764	IN	denotes	with
T10999	44765-44768	DT	denotes	the
T11000	44789-44796	NNS	denotes	numbers
T11001	44769-44778	VBG	denotes	following
T11002	44779-44788	NN	denotes	accession
T11003	44796-44798	:	denotes	:
T11004	44798-44802	NNP	denotes	Homo
T11005	44803-44810	NNP	denotes	sapiens
T11006	44831-44832	NN	denotes	S
T11007	44811-44816	NN	denotes	TACC1
T11008	44817-44822	JJ	denotes	short
T11009	44823-44830	NN	denotes	isoform
T11010	44833-44834	-LRB-	denotes	(
T11011	44834-44842	NN	denotes	AY177411
T11012	44842-44843	-RRB-	denotes	)
T11013	44843-44845	,	denotes	,
T11014	44845-44848	NNP	denotes	Mus
T11015	44849-44857	NNP	denotes	musculus
T11016	44878-44879	NN	denotes	S
T11017	44858-44863	NN	denotes	TACC1
T11018	44864-44869	JJ	denotes	short
T11019	44870-44877	NN	denotes	isoform
T11020	44880-44881	-LRB-	denotes	(
T11021	44881-44889	NN	denotes	AY177412
T11022	44889-44890	-RRB-	denotes	)
T11023	44890-44892	,	denotes	,
T11024	44892-44895	NNP	denotes	Mus
T11025	44896-44904	NNP	denotes	musculus
T11026	44924-44925	NN	denotes	A
T11027	44905-44910	NN	denotes	TACC1
T11028	44911-44915	JJ	denotes	long
T11029	44916-44923	NN	denotes	isoform
T11030	44926-44927	-LRB-	denotes	(
T11031	44927-44935	NN	denotes	AY177413
T11032	44935-44936	-RRB-	denotes	)
T11033	44936-44938	,	denotes	,
T11034	44938-44941	NNP	denotes	Mus
T11035	44942-44950	NNP	denotes	musculus
T11036	44951-44957	NNS	denotes	TACC2s
T11037	44958-44959	-LRB-	denotes	(
T11038	44959-44967	NN	denotes	AY177410
T11039	44967-44968	-RRB-	denotes	)
T11040	44968-44970	,	denotes	,
T11041	44970-44981	NNP	denotes	Oryctolagus
T11042	44982-44991	NNP	denotes	cuniculus
T11043	44992-44997	NN	denotes	TACC3
T11044	44998-44999	-LRB-	denotes	(
T11045	44999-45007	NN	denotes	AY161270
T11046	45007-45008	-RRB-	denotes	)
T11047	45008-45010	,	denotes	,
T11048	45010-45015	NNP	denotes	Danio
T11049	45016-45021	NNP	denotes	rerio
T11050	45022-45027	NN	denotes	TACC3
T11051	45028-45029	-LRB-	denotes	(
T11052	45029-45037	NN	denotes	AY170618
T11053	45037-45038	-RRB-	denotes	)
T11054	45038-45039	.	denotes	.
T11055	45039-45753	sentence	denotes	Annotations submitted to the Third party annotation database at NCBI are as follows: Rattus norvegus TACC1 long isoform A (BK001653), Takifugu rubripes TACC1A (BK000666/BK000667), Takifugu rubripes TACC1B (BK000664), Mus musculus TACC2l (BK001495), Rattus norvegus TACC2l (BK001658), Rattus norvegus TACC2s (BK001657), Takifugu rubripes TACC2l (BK000690), Rattus norvegus TACC3 (BK001491), Gallus gallus TACC3 (BK001482), Silurana tropicalis TACC3 (BK001481),Takifugu rubripes TACC3 (BK000649), Takifugu rubripes RHAMM (BK000676), Ciona intestinalis RHAMM (BK001479), Takifugu rubripes Keratin (BK000677), Takifugu rubripes TPM1 (BAC10576), Ciona intestinalis Kif3b (BK001492), Ciona intestinalis klp2 (BK001493).
T11056	45040-45051	NNS	denotes	Annotations
T11057	45109-45112	VBP	denotes	are
T11058	45052-45061	VBN	denotes	submitted
T11059	45062-45064	IN	denotes	to
T11060	45065-45068	DT	denotes	the
T11061	45092-45100	NN	denotes	database
T11062	45069-45074	JJ	denotes	Third
T11063	45075-45080	NN	denotes	party
T11064	45081-45091	NN	denotes	annotation
T11065	45101-45103	IN	denotes	at
T11066	45104-45108	NNP	denotes	NCBI
T11067	45113-45115	IN	denotes	as
T11068	45116-45123	VBZ	denotes	follows
T11069	45123-45125	:	denotes	:
T11070	45125-45131	NNP	denotes	Rattus
T11071	45132-45140	NNP	denotes	norvegus
T11072	45160-45161	NN	denotes	A
T11073	45141-45146	NN	denotes	TACC1
T11074	45147-45151	JJ	denotes	long
T11075	45152-45159	NN	denotes	isoform
T11076	45162-45163	-LRB-	denotes	(
T11077	45163-45171	NN	denotes	BK001653
T11078	45171-45172	-RRB-	denotes	)
T11079	45172-45174	,	denotes	,
T11080	45174-45182	NNP	denotes	Takifugu
T11081	45183-45191	NNP	denotes	rubripes
T11082	45192-45198	NN	denotes	TACC1A
T11083	45199-45200	-LRB-	denotes	(
T11084	45209-45217	NN	denotes	BK000667
T11085	45200-45208	NN	denotes	BK000666
T11086	45208-45209	HYPH	denotes	/
T11087	45217-45218	-RRB-	denotes	)
T11088	45218-45220	,	denotes	,
T11089	45220-45228	NNP	denotes	Takifugu
T11090	45229-45237	NNP	denotes	rubripes
T11091	45238-45244	NN	denotes	TACC1B
T11092	45245-45246	-LRB-	denotes	(
T11093	45246-45254	NN	denotes	BK000664
T11094	45254-45255	-RRB-	denotes	)
T11095	45255-45257	,	denotes	,
T11096	45257-45260	NNP	denotes	Mus
T11097	45261-45269	NNP	denotes	musculus
T11098	45270-45276	NN	denotes	TACC2l
T11099	45277-45278	-LRB-	denotes	(
T11100	45278-45286	NN	denotes	BK001495
T11101	45286-45287	-RRB-	denotes	)
T11102	45287-45289	,	denotes	,
T11103	45289-45295	NNP	denotes	Rattus
T11104	45296-45304	NNP	denotes	norvegus
T11105	45305-45311	NN	denotes	TACC2l
T11106	45312-45313	-LRB-	denotes	(
T11107	45313-45321	NN	denotes	BK001658
T11108	45321-45322	-RRB-	denotes	)
T11109	45322-45324	,	denotes	,
T11110	45324-45330	NNP	denotes	Rattus
T11111	45331-45339	NNP	denotes	norvegus
T11112	45340-45346	NNS	denotes	TACC2s
T11113	45347-45348	-LRB-	denotes	(
T11114	45348-45356	NN	denotes	BK001657
T11115	45356-45357	-RRB-	denotes	)
T11116	45357-45359	,	denotes	,
T11117	45359-45367	NNP	denotes	Takifugu
T11118	45368-45376	NNP	denotes	rubripes
T11119	45377-45383	NN	denotes	TACC2l
T11120	45384-45385	-LRB-	denotes	(
T11121	45385-45393	NN	denotes	BK000690
T11122	45393-45394	-RRB-	denotes	)
T11123	45394-45396	,	denotes	,
T11124	45396-45402	NNP	denotes	Rattus
T11125	45403-45411	NNP	denotes	norvegus
T11126	45412-45417	NN	denotes	TACC3
T11127	45418-45419	-LRB-	denotes	(
T11128	45419-45427	NN	denotes	BK001491
T11129	45427-45428	-RRB-	denotes	)
T11130	45428-45430	,	denotes	,
T11131	45430-45436	NNP	denotes	Gallus
T11132	45437-45443	NNP	denotes	gallus
T11133	45444-45449	NN	denotes	TACC3
T11134	45450-45451	-LRB-	denotes	(
T11135	45451-45459	NN	denotes	BK001482
T11136	45459-45460	-RRB-	denotes	)
T11137	45460-45462	,	denotes	,
T11138	45462-45470	NNP	denotes	Silurana
T11139	45471-45481	NNP	denotes	tropicalis
T11140	45482-45487	NN	denotes	TACC3
T11141	45488-45489	-LRB-	denotes	(
T11142	45489-45497	NN	denotes	BK001481
T11143	45497-45498	-RRB-	denotes	)
T11144	45498-45499	,	denotes	,
T11145	45499-45507	NNP	denotes	Takifugu
T11146	45508-45516	NNP	denotes	rubripes
T11147	45517-45522	NN	denotes	TACC3
T11148	45523-45524	-LRB-	denotes	(
T11149	45524-45532	NN	denotes	BK000649
T11150	45532-45533	-RRB-	denotes	)
T11151	45533-45535	,	denotes	,
T11152	45535-45543	NNP	denotes	Takifugu
T11153	45544-45552	NNP	denotes	rubripes
T11154	45553-45558	NN	denotes	RHAMM
T11155	45559-45560	-LRB-	denotes	(
T11156	45560-45568	NN	denotes	BK000676
T11157	45568-45569	-RRB-	denotes	)
T11158	45569-45571	,	denotes	,
T11159	45571-45576	NNP	denotes	Ciona
T11160	45577-45589	NNP	denotes	intestinalis
T11161	45590-45595	NN	denotes	RHAMM
T11162	45596-45597	-LRB-	denotes	(
T11163	45597-45605	NN	denotes	BK001479
T11164	45605-45606	-RRB-	denotes	)
T11165	45606-45608	,	denotes	,
T11166	45608-45616	NNP	denotes	Takifugu
T11167	45617-45625	NNP	denotes	rubripes
T11168	45626-45633	NN	denotes	Keratin
T11169	45634-45635	-LRB-	denotes	(
T11170	45635-45643	NN	denotes	BK000677
T11171	45643-45644	-RRB-	denotes	)
T11172	45644-45646	,	denotes	,
T11173	45646-45654	NNP	denotes	Takifugu
T11174	45655-45663	NNP	denotes	rubripes
T11175	45664-45668	NN	denotes	TPM1
T11176	45669-45670	-LRB-	denotes	(
T11177	45670-45678	NN	denotes	BAC10576
T11178	45678-45679	-RRB-	denotes	)
T11179	45679-45681	,	denotes	,
T11180	45681-45686	NNP	denotes	Ciona
T11181	45687-45699	NNP	denotes	intestinalis
T11182	45700-45705	NN	denotes	Kif3b
T11183	45706-45707	-LRB-	denotes	(
T11184	45707-45715	NN	denotes	BK001492
T11185	45715-45716	-RRB-	denotes	)
T11186	45716-45718	,	denotes	,
T11187	45718-45723	NNP	denotes	Ciona
T11188	45724-45736	NNP	denotes	intestinalis
T11189	45737-45741	NN	denotes	klp2
T11190	45742-45743	-LRB-	denotes	(
T11191	45743-45751	NN	denotes	BK001493
T11192	45751-45752	-RRB-	denotes	)
T11193	45752-45753	.	denotes	.
T11434	45755-45767	JJ	denotes	Phylogenetic
T11435	45768-45776	NN	denotes	analysis
T11436	45776-46260	sentence	denotes	In order to examine evolutionary relationships of proteins containing coiled coil domains, protein sequences representing the major members of this super family, including TACC, RHAMM, KLP, keratin and tropomyosin from available vertebrates and their recognizable orthologues from the urochordate Ciona intestinalis, Drosophila melanogaster, C. elegans and Saccharomyces cerevisiae were either directly retrieved from NCBI sequence databases, newly predicted or isolated (see above).
T11437	45777-45779	IN	denotes	In
T11438	46180-46189	VBN	denotes	retrieved
T11439	45780-45785	NN	denotes	order
T11440	45786-45788	TO	denotes	to
T11441	45789-45796	VB	denotes	examine
T11442	45797-45809	JJ	denotes	evolutionary
T11443	45810-45823	NNS	denotes	relationships
T11444	45824-45826	IN	denotes	of
T11445	45827-45835	NN	denotes	proteins
T11446	45836-45846	VBG	denotes	containing
T11447	45847-45853	VBN	denotes	coiled
T11448	45854-45858	NN	denotes	coil
T11449	45859-45866	NNS	denotes	domains
T11450	45866-45868	,	denotes	,
T11451	45868-45875	NN	denotes	protein
T11452	45876-45885	NNS	denotes	sequences
T11453	45886-45898	VBG	denotes	representing
T11454	45899-45902	DT	denotes	the
T11455	45909-45916	NNS	denotes	members
T11456	45903-45908	JJ	denotes	major
T11457	45917-45919	IN	denotes	of
T11458	45920-45924	DT	denotes	this
T11459	45931-45937	NN	denotes	family
T11460	45925-45930	JJ	denotes	super
T11461	45937-45939	,	denotes	,
T11462	45939-45948	VBG	denotes	including
T11463	45949-45953	NN	denotes	TACC
T11464	45953-45955	,	denotes	,
T11465	45955-45960	NN	denotes	RHAMM
T11466	45960-45962	,	denotes	,
T11467	45962-45965	NN	denotes	KLP
T11468	45965-45967	,	denotes	,
T11469	45967-45974	NN	denotes	keratin
T11470	45975-45978	CC	denotes	and
T11471	45979-45990	NN	denotes	tropomyosin
T11472	45991-45995	IN	denotes	from
T11473	45996-46005	JJ	denotes	available
T11474	46006-46017	NNS	denotes	vertebrates
T11475	46018-46021	CC	denotes	and
T11476	46022-46027	PRP$	denotes	their
T11477	46041-46052	NNS	denotes	orthologues
T11478	46028-46040	JJ	denotes	recognizable
T11479	46053-46057	IN	denotes	from
T11480	46058-46061	DT	denotes	the
T11481	46062-46073	NN	denotes	urochordate
T11482	46074-46079	NNP	denotes	Ciona
T11483	46080-46092	NNP	denotes	intestinalis
T11484	46092-46094	,	denotes	,
T11485	46094-46104	NNP	denotes	Drosophila
T11486	46105-46117	NNP	denotes	melanogaster
T11487	46117-46119	,	denotes	,
T11488	46119-46121	NNP	denotes	C.
T11489	46122-46129	NNP	denotes	elegans
T11490	46130-46133	CC	denotes	and
T11491	46134-46147	NNP	denotes	Saccharomyces
T11492	46148-46158	NNP	denotes	cerevisiae
T11493	46159-46163	VBD	denotes	were
T11494	46164-46170	CC	denotes	either
T11495	46171-46179	RB	denotes	directly
T11496	46190-46194	IN	denotes	from
T11497	46195-46199	NN	denotes	NCBI
T11498	46209-46218	NNS	denotes	databases
T11499	46200-46208	NN	denotes	sequence
T11500	46218-46220	,	denotes	,
T11501	46220-46225	RB	denotes	newly
T11502	46226-46235	VBN	denotes	predicted
T11503	46236-46238	CC	denotes	or
T11504	46239-46247	VBN	denotes	isolated
T11505	46248-46249	-LRB-	denotes	(
T11506	46249-46252	VB	denotes	see
T11507	46253-46258	RB	denotes	above
T11508	46258-46259	-RRB-	denotes	)
T11509	46259-46260	.	denotes	.
T11510	46260-46590	sentence	denotes	Species abbreviations are as follows: hs (Homo sapiens), mm (Mus musculus), rn (Rattus norvegus), oc (Oryctolagus cuniculus), gg (Gallus gallus), xl (Xenopus laevis), st (Silurana tropicalis), tr (Takifugu rubripes), dr (Danio rerio), ci (Ciona intestinalis), dm (D. melanogaster), ce (C. elegans), sc (Saccharomyces cerevisiae).
T11511	46261-46268	NN	denotes	Species
T11512	46269-46282	NNS	denotes	abbreviations
T11513	46283-46286	VBP	denotes	are
T11514	46287-46289	IN	denotes	as
T11515	46290-46297	VBZ	denotes	follows
T11516	46297-46299	:	denotes	:
T11517	46299-46301	NNP	denotes	hs
T11518	46302-46303	-LRB-	denotes	(
T11519	46303-46307	NNP	denotes	Homo
T11520	46308-46315	NNP	denotes	sapiens
T11521	46315-46316	-RRB-	denotes	)
T11522	46316-46318	,	denotes	,
T11523	46318-46320	NNP	denotes	mm
T11524	46321-46322	-LRB-	denotes	(
T11525	46322-46325	NNP	denotes	Mus
T11526	46326-46334	NNP	denotes	musculus
T11527	46334-46335	-RRB-	denotes	)
T11528	46335-46337	,	denotes	,
T11529	46337-46339	NNP	denotes	rn
T11530	46340-46341	-LRB-	denotes	(
T11531	46341-46347	NNP	denotes	Rattus
T11532	46348-46356	NNP	denotes	norvegus
T11533	46356-46357	-RRB-	denotes	)
T11534	46357-46359	,	denotes	,
T11535	46359-46361	NNP	denotes	oc
T11536	46362-46363	-LRB-	denotes	(
T11537	46363-46374	NNP	denotes	Oryctolagus
T11538	46375-46384	NNP	denotes	cuniculus
T11539	46384-46385	-RRB-	denotes	)
T11540	46385-46387	,	denotes	,
T11541	46387-46389	NNP	denotes	gg
T11542	46390-46391	-LRB-	denotes	(
T11543	46391-46397	NNP	denotes	Gallus
T11544	46398-46404	NNP	denotes	gallus
T11545	46404-46405	-RRB-	denotes	)
T11546	46405-46407	,	denotes	,
T11547	46407-46409	NNP	denotes	xl
T11548	46410-46411	-LRB-	denotes	(
T11549	46411-46418	NNP	denotes	Xenopus
T11550	46419-46425	NNP	denotes	laevis
T11551	46425-46426	-RRB-	denotes	)
T11552	46426-46428	,	denotes	,
T11553	46428-46430	NNP	denotes	st
T11554	46431-46432	-LRB-	denotes	(
T11555	46432-46440	NNP	denotes	Silurana
T11556	46441-46451	NNP	denotes	tropicalis
T11557	46451-46452	-RRB-	denotes	)
T11558	46452-46454	,	denotes	,
T11559	46454-46456	NNP	denotes	tr
T11560	46457-46458	-LRB-	denotes	(
T11561	46458-46466	NNP	denotes	Takifugu
T11562	46467-46475	NNP	denotes	rubripes
T11563	46475-46476	-RRB-	denotes	)
T11564	46476-46478	,	denotes	,
T11565	46478-46480	NNP	denotes	dr
T11566	46481-46482	-LRB-	denotes	(
T11567	46482-46487	NNP	denotes	Danio
T11568	46488-46493	NNP	denotes	rerio
T11569	46493-46494	-RRB-	denotes	)
T11570	46494-46496	,	denotes	,
T11571	46496-46498	NNP	denotes	ci
T11572	46499-46500	-LRB-	denotes	(
T11573	46500-46505	NNP	denotes	Ciona
T11574	46506-46518	NNP	denotes	intestinalis
T11575	46518-46519	-RRB-	denotes	)
T11576	46519-46521	,	denotes	,
T11577	46521-46523	NN	denotes	dm
T11578	46524-46525	-LRB-	denotes	(
T11579	46525-46527	NNP	denotes	D.
T11580	46528-46540	NNP	denotes	melanogaster
T11581	46540-46541	-RRB-	denotes	)
T11582	46541-46543	,	denotes	,
T11583	46543-46545	NNP	denotes	ce
T11584	46546-46547	-LRB-	denotes	(
T11585	46547-46549	NNP	denotes	C.
T11586	46550-46557	NNP	denotes	elegans
T11587	46557-46558	-RRB-	denotes	)
T11588	46558-46560	,	denotes	,
T11589	46560-46562	NNP	denotes	sc
T11590	46563-46564	-LRB-	denotes	(
T11591	46564-46577	NNP	denotes	Saccharomyces
T11592	46578-46588	NNP	denotes	cerevisiae
T11593	46588-46589	-RRB-	denotes	)
T11594	46589-46590	.	denotes	.
T11595	46590-47558	sentence	denotes	The sequences identified above and the following protein or predicted translations were used for phylogenetic analysis: hsTACC1A (NP_006274), hsTACC2l (AAO62630) hsTACC2s (AAO62629), hsTACC3 (NP_006333), mmTACC3 (Q9JJ11), xlMaskin (Q9PTG8), dmTACC (AAF52099), ceTAC1 (NP_497059), scSPC72 (NP_009352), hsRHAMM (NP_036616), mmRHAMM (NP_038580), rnRHAMM (NP_037096), drRHAMM (AAQ97980), hsKeratin (CAB76828), mmKeratin (A61368), rnKeratin (XP_235679), hsTPM1 (NP_000357), mmTPM1 (NP_077745), rnTPM1 (NP_62004, drTPM1 (NP_571180) dmTPM1 (P06754), ceTPM (NP_493540) scTPM1 (P17536), hsKLP2 (BAB03309), rnKIF15 (AAP44513), xlKLP2 (CAA08879), dmKLP2 (NP_476818), ceKLP18 (AA034669), hsKIF3A (Q9Y496), mmKIF3A (NP_032469), rnKIF3A (XP_340797), xlKIF3A (CAA08879), ceKLP11 (NP_741473), ciKIF3 (ci0100148992), hsKIF3B (NP_004789), mmKIF3B (NP_004789), rnKIF3B (XP_215883), dmKIF3B (NP_524029), hsKIF3C (NP_002245), mmKIF3C (NP_032471), rnKIF3C (NP_445938), dmKIF3C (NP_651939).
T11596	46591-46594	DT	denotes	The
T11597	46595-46604	NNS	denotes	sequences
T11598	46679-46683	VBN	denotes	used
T11599	46605-46615	VBN	denotes	identified
T11600	46616-46621	RB	denotes	above
T11601	46622-46625	CC	denotes	and
T11602	46626-46629	DT	denotes	the
T11603	46661-46673	NNS	denotes	translations
T11604	46630-46639	VBG	denotes	following
T11605	46640-46647	NN	denotes	protein
T11606	46648-46650	CC	denotes	or
T11607	46651-46660	VBN	denotes	predicted
T11608	46674-46678	VBD	denotes	were
T11609	46684-46687	IN	denotes	for
T11610	46688-46700	JJ	denotes	phylogenetic
T11611	46701-46709	NN	denotes	analysis
T11612	46709-46711	:	denotes	:
T11613	46711-46719	NN	denotes	hsTACC1A
T11614	46720-46721	-LRB-	denotes	(
T11615	46721-46730	NN	denotes	NP_006274
T11616	46730-46731	-RRB-	denotes	)
T11617	46731-46733	,	denotes	,
T11618	46733-46741	NN	denotes	hsTACC2l
T11619	46742-46743	-LRB-	denotes	(
T11620	46743-46751	NN	denotes	AAO62630
T11621	46751-46752	-RRB-	denotes	)
T11622	46753-46761	NN	denotes	hsTACC2s
T11623	46762-46763	-LRB-	denotes	(
T11624	46763-46771	NN	denotes	AAO62629
T11625	46771-46772	-RRB-	denotes	)
T11626	46772-46774	,	denotes	,
T11627	46774-46781	NN	denotes	hsTACC3
T11628	46782-46783	-LRB-	denotes	(
T11629	46783-46792	NN	denotes	NP_006333
T11630	46792-46793	-RRB-	denotes	)
T11631	46793-46795	,	denotes	,
T11632	46795-46802	NN	denotes	mmTACC3
T11633	46803-46804	-LRB-	denotes	(
T11634	46804-46810	NN	denotes	Q9JJ11
T11635	46810-46811	-RRB-	denotes	)
T11636	46811-46813	,	denotes	,
T11637	46813-46821	NN	denotes	xlMaskin
T11638	46822-46823	-LRB-	denotes	(
T11639	46823-46829	NN	denotes	Q9PTG8
T11640	46829-46830	-RRB-	denotes	)
T11641	46830-46832	,	denotes	,
T11642	46832-46838	NN	denotes	dmTACC
T11643	46839-46840	-LRB-	denotes	(
T11644	46840-46848	NN	denotes	AAF52099
T11645	46848-46849	-RRB-	denotes	)
T11646	46849-46851	,	denotes	,
T11647	46851-46857	NN	denotes	ceTAC1
T11648	46858-46859	-LRB-	denotes	(
T11649	46859-46868	NN	denotes	NP_497059
T11650	46868-46869	-RRB-	denotes	)
T11651	46869-46871	,	denotes	,
T11652	46871-46878	NN	denotes	scSPC72
T11653	46879-46880	-LRB-	denotes	(
T11654	46880-46889	NN	denotes	NP_009352
T11655	46889-46890	-RRB-	denotes	)
T11656	46890-46892	,	denotes	,
T11657	46892-46899	NN	denotes	hsRHAMM
T11658	46900-46901	-LRB-	denotes	(
T11659	46901-46910	NN	denotes	NP_036616
T11660	46910-46911	-RRB-	denotes	)
T11661	46911-46913	,	denotes	,
T11662	46913-46920	NN	denotes	mmRHAMM
T11663	46921-46922	-LRB-	denotes	(
T11664	46922-46931	NN	denotes	NP_038580
T11665	46931-46932	-RRB-	denotes	)
T11666	46932-46934	,	denotes	,
T11667	46934-46941	NN	denotes	rnRHAMM
T11668	46942-46943	-LRB-	denotes	(
T11669	46943-46952	NN	denotes	NP_037096
T11670	46952-46953	-RRB-	denotes	)
T11671	46953-46955	,	denotes	,
T11672	46955-46962	NN	denotes	drRHAMM
T11673	46963-46964	-LRB-	denotes	(
T11674	46964-46972	NN	denotes	AAQ97980
T11675	46972-46973	-RRB-	denotes	)
T11676	46973-46975	,	denotes	,
T11677	46975-46984	NN	denotes	hsKeratin
T11678	46985-46986	-LRB-	denotes	(
T11679	46986-46994	NN	denotes	CAB76828
T11680	46994-46995	-RRB-	denotes	)
T11681	46995-46997	,	denotes	,
T11682	46997-47006	NN	denotes	mmKeratin
T11683	47007-47008	-LRB-	denotes	(
T11684	47008-47014	NN	denotes	A61368
T11685	47014-47015	-RRB-	denotes	)
T11686	47015-47017	,	denotes	,
T11687	47017-47026	NN	denotes	rnKeratin
T11688	47027-47028	-LRB-	denotes	(
T11689	47028-47037	NN	denotes	XP_235679
T11690	47037-47038	-RRB-	denotes	)
T11691	47038-47040	,	denotes	,
T11692	47040-47046	NN	denotes	hsTPM1
T11693	47047-47048	-LRB-	denotes	(
T11694	47048-47057	NN	denotes	NP_000357
T11695	47057-47058	-RRB-	denotes	)
T11696	47058-47060	,	denotes	,
T11697	47060-47066	NN	denotes	mmTPM1
T11698	47067-47068	-LRB-	denotes	(
T11699	47068-47077	NN	denotes	NP_077745
T11700	47077-47078	-RRB-	denotes	)
T11701	47078-47080	,	denotes	,
T11702	47080-47086	NN	denotes	rnTPM1
T11703	47087-47088	-LRB-	denotes	(
T11704	47088-47096	NN	denotes	NP_62004
T11705	47096-47098	,	denotes	,
T11706	47098-47104	NN	denotes	drTPM1
T11707	47105-47106	-LRB-	denotes	(
T11708	47106-47115	NN	denotes	NP_571180
T11709	47115-47116	-RRB-	denotes	)
T11710	47117-47123	NN	denotes	dmTPM1
T11711	47124-47125	-LRB-	denotes	(
T11712	47125-47131	NN	denotes	P06754
T11713	47131-47132	-RRB-	denotes	)
T11714	47132-47134	,	denotes	,
T11715	47134-47139	NN	denotes	ceTPM
T11716	47140-47141	-LRB-	denotes	(
T11717	47141-47150	NN	denotes	NP_493540
T11718	47150-47151	-RRB-	denotes	)
T11719	47152-47158	NN	denotes	scTPM1
T11720	47159-47160	-LRB-	denotes	(
T11721	47160-47166	NN	denotes	P17536
T11722	47166-47167	-RRB-	denotes	)
T11723	47167-47169	,	denotes	,
T11724	47169-47175	NN	denotes	hsKLP2
T11725	47176-47177	-LRB-	denotes	(
T11726	47177-47185	NN	denotes	BAB03309
T11727	47185-47186	-RRB-	denotes	)
T11728	47186-47188	,	denotes	,
T11729	47188-47195	NN	denotes	rnKIF15
T11730	47196-47197	-LRB-	denotes	(
T11731	47197-47205	NN	denotes	AAP44513
T11732	47205-47206	-RRB-	denotes	)
T11733	47206-47208	,	denotes	,
T11734	47208-47214	NN	denotes	xlKLP2
T11735	47215-47216	-LRB-	denotes	(
T11736	47216-47224	NN	denotes	CAA08879
T11737	47224-47225	-RRB-	denotes	)
T11738	47225-47227	,	denotes	,
T11739	47227-47233	NN	denotes	dmKLP2
T11740	47234-47235	-LRB-	denotes	(
T11741	47235-47244	NN	denotes	NP_476818
T11742	47244-47245	-RRB-	denotes	)
T11743	47245-47247	,	denotes	,
T11744	47247-47254	NN	denotes	ceKLP18
T11745	47255-47256	-LRB-	denotes	(
T11746	47256-47264	NN	denotes	AA034669
T11747	47264-47265	-RRB-	denotes	)
T11748	47265-47267	,	denotes	,
T11749	47267-47274	NN	denotes	hsKIF3A
T11750	47275-47276	-LRB-	denotes	(
T11751	47276-47282	NN	denotes	Q9Y496
T11752	47282-47283	-RRB-	denotes	)
T11753	47283-47285	,	denotes	,
T11754	47285-47292	NN	denotes	mmKIF3A
T11755	47293-47294	-LRB-	denotes	(
T11756	47294-47303	NN	denotes	NP_032469
T11757	47303-47304	-RRB-	denotes	)
T11758	47304-47306	,	denotes	,
T11759	47306-47313	NN	denotes	rnKIF3A
T11760	47314-47315	-LRB-	denotes	(
T11761	47315-47324	NN	denotes	XP_340797
T11762	47324-47325	-RRB-	denotes	)
T11763	47325-47327	,	denotes	,
T11764	47327-47334	NN	denotes	xlKIF3A
T11765	47335-47336	-LRB-	denotes	(
T11766	47336-47344	NN	denotes	CAA08879
T11767	47344-47345	-RRB-	denotes	)
T11768	47345-47347	,	denotes	,
T11769	47347-47354	NN	denotes	ceKLP11
T11770	47355-47356	-LRB-	denotes	(
T11771	47356-47365	NN	denotes	NP_741473
T11772	47365-47366	-RRB-	denotes	)
T11773	47366-47368	,	denotes	,
T11774	47368-47374	NN	denotes	ciKIF3
T11775	47375-47376	-LRB-	denotes	(
T11776	47376-47388	NN	denotes	ci0100148992
T11777	47388-47389	-RRB-	denotes	)
T11778	47389-47391	,	denotes	,
T11779	47391-47398	NN	denotes	hsKIF3B
T11780	47399-47400	-LRB-	denotes	(
T11781	47400-47409	NN	denotes	NP_004789
T11782	47409-47410	-RRB-	denotes	)
T11783	47410-47412	,	denotes	,
T11784	47412-47419	NN	denotes	mmKIF3B
T11785	47420-47421	-LRB-	denotes	(
T11786	47421-47430	NN	denotes	NP_004789
T11787	47430-47431	-RRB-	denotes	)
T11788	47431-47433	,	denotes	,
T11789	47433-47440	NN	denotes	rnKIF3B
T11790	47441-47442	-LRB-	denotes	(
T11791	47442-47451	NN	denotes	XP_215883
T11792	47451-47452	-RRB-	denotes	)
T11793	47452-47454	,	denotes	,
T11794	47454-47461	NN	denotes	dmKIF3B
T11795	47462-47463	-LRB-	denotes	(
T11796	47463-47472	NN	denotes	NP_524029
T11797	47472-47473	-RRB-	denotes	)
T11798	47473-47475	,	denotes	,
T11799	47475-47482	NN	denotes	hsKIF3C
T11800	47483-47484	-LRB-	denotes	(
T11801	47484-47493	NN	denotes	NP_002245
T11802	47493-47494	-RRB-	denotes	)
T11803	47494-47496	,	denotes	,
T11804	47496-47503	NN	denotes	mmKIF3C
T11805	47504-47505	-LRB-	denotes	(
T11806	47505-47514	NN	denotes	NP_032471
T11807	47514-47515	-RRB-	denotes	)
T11808	47515-47517	,	denotes	,
T11809	47517-47524	NN	denotes	rnKIF3C
T11810	47525-47526	-LRB-	denotes	(
T11811	47526-47535	NN	denotes	NP_445938
T11812	47535-47536	-RRB-	denotes	)
T11813	47536-47538	,	denotes	,
T11814	47538-47545	NN	denotes	dmKIF3C
T11815	47546-47547	-LRB-	denotes	(
T11816	47547-47556	NN	denotes	NP_651939
T11817	47556-47557	-RRB-	denotes	)
T11818	47557-47558	.	denotes	.
T11819	47558-47626	sentence	denotes	These protein sequences were initially aligned with CLUSTAL X [38].
T11820	47559-47564	DT	denotes	These
T11821	47573-47582	NNS	denotes	sequences
T11822	47565-47572	NN	denotes	protein
T11823	47598-47605	VBN	denotes	aligned
T11824	47583-47587	VBD	denotes	were
T11825	47588-47597	RB	denotes	initially
T11826	47606-47610	IN	denotes	with
T11827	47611-47618	NNP	denotes	CLUSTAL
T11828	47619-47620	NNP	denotes	X
T11829	47621-47622	-LRB-	denotes	[
T11830	47622-47624	CD	denotes	38
T11831	47624-47625	-RRB-	denotes	]
T11832	47625-47626	.	denotes	.
T11833	47626-47962	sentence	denotes	Minor adjustments to certain regions of the alignment for optimization purposes were made based on pairwise alignments, the output saved in PHYLIP format, after which, the distances between proteins were calculated using Poisson correction and the Unrooted trees were inferred with the NJ method and then displayed using TreeView [39].
T11834	47627-47632	JJ	denotes	Minor
T11835	47633-47644	NNS	denotes	adjustments
T11836	47712-47716	VBN	denotes	made
T11837	47645-47647	IN	denotes	to
T11838	47648-47655	JJ	denotes	certain
T11839	47656-47663	NNS	denotes	regions
T11840	47664-47666	IN	denotes	of
T11841	47667-47670	DT	denotes	the
T11842	47671-47680	NN	denotes	alignment
T11843	47681-47684	IN	denotes	for
T11844	47685-47697	NN	denotes	optimization
T11845	47698-47706	NNS	denotes	purposes
T11846	47707-47711	VBD	denotes	were
T11847	47758-47763	VBD	denotes	saved
T11848	47717-47722	VBN	denotes	based
T11849	47723-47725	IN	denotes	on
T11850	47726-47734	JJ	denotes	pairwise
T11851	47735-47745	NNS	denotes	alignments
T11852	47745-47747	,	denotes	,
T11853	47747-47750	DT	denotes	the
T11854	47751-47757	NN	denotes	output
T11855	47764-47766	IN	denotes	in
T11856	47767-47773	NN	denotes	PHYLIP
T11857	47774-47780	NN	denotes	format
T11858	47780-47782	,	denotes	,
T11859	47782-47787	IN	denotes	after
T11860	47831-47841	VBN	denotes	calculated
T11861	47788-47793	WDT	denotes	which
T11862	47793-47795	,	denotes	,
T11863	47795-47798	DT	denotes	the
T11864	47799-47808	NNS	denotes	distances
T11865	47809-47816	IN	denotes	between
T11866	47817-47825	NN	denotes	proteins
T11867	47826-47830	VBD	denotes	were
T11868	47842-47847	VBG	denotes	using
T11869	47848-47855	NNP	denotes	Poisson
T11870	47856-47866	NN	denotes	correction
T11871	47867-47870	CC	denotes	and
T11872	47871-47874	DT	denotes	the
T11873	47884-47889	NNS	denotes	trees
T11874	47875-47883	JJ	denotes	Unrooted
T11875	47895-47903	VBN	denotes	inferred
T11876	47890-47894	VBD	denotes	were
T11877	47904-47908	IN	denotes	with
T11878	47909-47912	DT	denotes	the
T11879	47916-47922	NN	denotes	method
T11880	47913-47915	NN	denotes	NJ
T11881	47923-47926	CC	denotes	and
T11882	47927-47931	RB	denotes	then
T11883	47932-47941	VBD	denotes	displayed
T11884	47942-47947	VBG	denotes	using
T11885	47948-47956	NNP	denotes	TreeView
T11886	47957-47958	-LRB-	denotes	[
T11887	47958-47960	CD	denotes	39
T11888	47960-47961	-RRB-	denotes	]
T11889	47961-47962	.	denotes	.
T11890	47962-48028	sentence	denotes	Bootstrap values above 700 for 1000 trials are shown at the node.
T11891	47963-47972	NN	denotes	Bootstrap
T11892	47973-47979	NNS	denotes	values
T11893	48010-48015	VBN	denotes	shown
T11894	47980-47985	IN	denotes	above
T11895	47986-47989	CD	denotes	700
T11896	47990-47993	IN	denotes	for
T11897	47994-47998	CD	denotes	1000
T11898	47999-48005	NNS	denotes	trials
T11899	48006-48009	VBP	denotes	are
T11900	48016-48018	IN	denotes	at
T11901	48019-48022	DT	denotes	the
T11902	48023-48027	NN	denotes	node
T11903	48027-48028	.	denotes	.
T11904	48028-48204	sentence	denotes	To validate the tree, the same sequence set was analyzed with tools in the PHYLIP package [40], using PRODIST followed by FITCH or NEIGNBOR and tree displaying using TreeView.
T11905	48029-48031	TO	denotes	To
T11906	48032-48040	VB	denotes	validate
T11907	48077-48085	VBN	denotes	analyzed
T11908	48041-48044	DT	denotes	the
T11909	48045-48049	NN	denotes	tree
T11910	48049-48051	,	denotes	,
T11911	48051-48054	DT	denotes	the
T11912	48069-48072	NN	denotes	set
T11913	48055-48059	JJ	denotes	same
T11914	48060-48068	NN	denotes	sequence
T11915	48073-48076	VBD	denotes	was
T11916	48086-48090	IN	denotes	with
T11917	48091-48096	NNS	denotes	tools
T11918	48097-48099	IN	denotes	in
T11919	48100-48103	DT	denotes	the
T11920	48111-48118	NN	denotes	package
T11921	48104-48110	NN	denotes	PHYLIP
T11922	48119-48120	-LRB-	denotes	[
T11923	48120-48122	CD	denotes	40
T11924	48122-48123	-RRB-	denotes	]
T11925	48123-48125	,	denotes	,
T11926	48125-48130	VBG	denotes	using
T11927	48131-48138	NN	denotes	PRODIST
T11928	48139-48147	VBN	denotes	followed
T11929	48148-48150	IN	denotes	by
T11930	48151-48156	NN	denotes	FITCH
T11931	48157-48159	CC	denotes	or
T11932	48160-48168	NN	denotes	NEIGNBOR
T11933	48169-48172	CC	denotes	and
T11934	48173-48177	NN	denotes	tree
T11935	48178-48188	VBG	denotes	displaying
T11936	48189-48194	VBG	denotes	using
T11937	48195-48203	NNP	denotes	TreeView
T11938	48203-48204	.	denotes	.
T11939	48204-48295	sentence	denotes	This additional method produced trees with essentially the same topology (data not shown).
T11940	48205-48209	DT	denotes	This
T11941	48221-48227	NN	denotes	method
T11942	48210-48220	JJ	denotes	additional
T11943	48228-48236	VBD	denotes	produced
T11944	48237-48242	NNS	denotes	trees
T11945	48243-48247	IN	denotes	with
T11946	48248-48259	RB	denotes	essentially
T11947	48269-48277	NN	denotes	topology
T11948	48260-48263	DT	denotes	the
T11949	48264-48268	JJ	denotes	same
T11950	48278-48279	-LRB-	denotes	(
T11951	48288-48293	VBN	denotes	shown
T11952	48279-48283	NNS	denotes	data
T11953	48284-48287	RB	denotes	not
T11954	48293-48294	-RRB-	denotes	)
T11955	48294-48295	.	denotes	.
T12120	48297-48299	FW	denotes	In
T12121	48300-48305	FW	denotes	vitro
T12122	48306-48317	NN	denotes	interaction
T12123	48318-48320	IN	denotes	of
T12124	48321-48326	NN	denotes	TACC2
T12125	48327-48330	CC	denotes	and
T12126	48331-48336	NN	denotes	RXRβ3
T12127	48336-48438	sentence	denotes	The TACC2 cDNA was cloned into GST fusion vector pGEX5X2 (Amersham Biosciences, Piscataway, NJ, USA).
T12128	48337-48340	DT	denotes	The
T12129	48347-48351	NN	denotes	cDNA
T12130	48341-48346	NN	denotes	TACC2
T12131	48356-48362	VBN	denotes	cloned
T12132	48352-48355	VBD	denotes	was
T12133	48363-48367	IN	denotes	into
T12134	48368-48371	NN	denotes	GST
T12135	48386-48393	NN	denotes	pGEX5X2
T12136	48372-48378	NN	denotes	fusion
T12137	48379-48385	NN	denotes	vector
T12138	48394-48395	-LRB-	denotes	(
T12139	48404-48415	NNP	denotes	Biosciences
T12140	48395-48403	NNP	denotes	Amersham
T12141	48415-48417	,	denotes	,
T12142	48417-48427	NNP	denotes	Piscataway
T12143	48427-48429	,	denotes	,
T12144	48429-48431	NNP	denotes	NJ
T12145	48431-48433	,	denotes	,
T12146	48433-48436	NNP	denotes	USA
T12147	48436-48437	-RRB-	denotes	)
T12148	48437-48438	.	denotes	.
T12149	48438-48551	sentence	denotes	GST and GST-TACC2 proteins were expressed in E. coli BL21(DE3) plys "S" with 1 mM IPTG at 37°C shaker for 2 hrs.
T12150	48439-48442	NN	denotes	GST
T12151	48457-48465	NN	denotes	proteins
T12152	48443-48446	CC	denotes	and
T12153	48447-48450	NN	denotes	GST
T12154	48451-48456	NN	denotes	TACC2
T12155	48450-48451	HYPH	denotes	-
T12156	48471-48480	VBN	denotes	expressed
T12157	48466-48470	VBD	denotes	were
T12158	48481-48483	IN	denotes	in
T12159	48484-48486	NNP	denotes	E.
T12160	48487-48491	NNP	denotes	coli
T12161	48508-48509	NN	denotes	S
T12162	48492-48496	NN	denotes	BL21
T12163	48496-48497	-LRB-	denotes	(
T12164	48497-48500	NN	denotes	DE3
T12165	48500-48501	-RRB-	denotes	)
T12166	48502-48506	NNS	denotes	plys
T12167	48507-48508	``	denotes	"
T12168	48509-48510	''	denotes	"
T12169	48511-48515	IN	denotes	with
T12170	48516-48517	CD	denotes	1
T12171	48518-48520	NN	denotes	mM
T12172	48521-48525	NN	denotes	IPTG
T12173	48526-48528	IN	denotes	at
T12174	48529-48531	CD	denotes	37
T12175	48531-48533	NN	denotes	°C
T12176	48534-48540	NN	denotes	shaker
T12177	48541-48544	IN	denotes	for
T12178	48545-48546	CD	denotes	2
T12179	48547-48550	NNS	denotes	hrs
T12180	48550-48551	.	denotes	.
T12181	48551-48701	sentence	denotes	Cells (50 ml) were harvested and resuspended in 5 ml of 20 mM Tris-HCl pH.8.0, 200 mM NaCl, 1 mM EDTA pH8.0, Protease inhibitor set III (Calbiochem).
T12182	48552-48557	NNS	denotes	Cells
T12183	48571-48580	VBN	denotes	harvested
T12184	48558-48559	-LRB-	denotes	(
T12185	48562-48564	NN	denotes	ml
T12186	48559-48561	CD	denotes	50
T12187	48564-48565	-RRB-	denotes	)
T12188	48566-48570	VBD	denotes	were
T12189	48581-48584	CC	denotes	and
T12190	48585-48596	VBN	denotes	resuspended
T12191	48597-48599	IN	denotes	in
T12192	48600-48601	CD	denotes	5
T12193	48602-48604	NN	denotes	ml
T12194	48605-48607	IN	denotes	of
T12195	48608-48610	CD	denotes	20
T12196	48611-48613	NN	denotes	mM
T12197	48619-48622	NN	denotes	HCl
T12198	48614-48618	NN	denotes	Tris
T12199	48618-48619	HYPH	denotes	-
T12200	48623-48629	NN	denotes	pH.8.0
T12201	48629-48631	,	denotes	,
T12202	48631-48634	CD	denotes	200
T12203	48635-48637	NN	denotes	mM
T12204	48638-48642	NN	denotes	NaCl
T12205	48642-48644	,	denotes	,
T12206	48644-48645	CD	denotes	1
T12207	48646-48648	NN	denotes	mM
T12208	48649-48653	NN	denotes	EDTA
T12209	48654-48659	NN	denotes	pH8.0
T12210	48659-48661	,	denotes	,
T12211	48661-48669	NN	denotes	Protease
T12212	48670-48679	NN	denotes	inhibitor
T12213	48680-48683	NN	denotes	set
T12214	48684-48687	CD	denotes	III
T12215	48688-48689	-LRB-	denotes	(
T12216	48689-48699	NNP	denotes	Calbiochem
T12217	48699-48700	-RRB-	denotes	)
T12218	48700-48701	.	denotes	.
T12219	48701-48804	sentence	denotes	The cells were lysed by sonication and lysate cleared by centrifugation at 7500 rpm at 4°C for 15 min.
T12220	48702-48705	DT	denotes	The
T12221	48706-48711	NNS	denotes	cells
T12222	48717-48722	VBN	denotes	lysed
T12223	48712-48716	VBD	denotes	were
T12224	48723-48725	IN	denotes	by
T12225	48726-48736	NN	denotes	sonication
T12226	48737-48740	CC	denotes	and
T12227	48741-48747	NN	denotes	lysate
T12228	48748-48755	VBN	denotes	cleared
T12229	48756-48758	IN	denotes	by
T12230	48759-48773	NN	denotes	centrifugation
T12231	48774-48776	IN	denotes	at
T12232	48777-48781	CD	denotes	7500
T12233	48782-48785	NN	denotes	rpm
T12234	48786-48788	IN	denotes	at
T12235	48789-48790	CD	denotes	4
T12236	48790-48792	NN	denotes	°C
T12237	48793-48796	IN	denotes	for
T12238	48797-48799	CD	denotes	15
T12239	48800-48803	NN	denotes	min
T12240	48803-48804	.	denotes	.
T12241	48804-48935	sentence	denotes	The cleared lysate was immobilized on glutathione sepharose beads in 3 ml of 20 mM Tris-HCl pH.8.0, 200 mM NaCl, 1 mM EDTA pH8.0).
T12242	48805-48808	DT	denotes	The
T12243	48817-48823	NN	denotes	lysate
T12244	48809-48816	JJ	denotes	cleared
T12245	48828-48839	VBN	denotes	immobilized
T12246	48824-48827	VBD	denotes	was
T12247	48840-48842	IN	denotes	on
T12248	48843-48854	NN	denotes	glutathione
T12249	48855-48864	NN	denotes	sepharose
T12250	48865-48870	NNS	denotes	beads
T12251	48871-48873	IN	denotes	in
T12252	48874-48875	CD	denotes	3
T12253	48876-48878	NN	denotes	ml
T12254	48879-48881	IN	denotes	of
T12255	48882-48884	CD	denotes	20
T12256	48885-48887	NN	denotes	mM
T12257	48893-48896	NN	denotes	HCl
T12258	48888-48892	NN	denotes	Tris
T12259	48892-48893	HYPH	denotes	-
T12260	48897-48903	NN	denotes	pH.8.0
T12261	48903-48905	,	denotes	,
T12262	48905-48908	CD	denotes	200
T12263	48909-48911	NN	denotes	mM
T12264	48912-48916	NN	denotes	NaCl
T12265	48916-48918	,	denotes	,
T12266	48918-48919	CD	denotes	1
T12267	48920-48922	NN	denotes	mM
T12268	48923-48927	NN	denotes	EDTA
T12269	48928-48933	NN	denotes	pH8.0
T12270	48933-48934	-RRB-	denotes	)
T12271	48934-48935	.	denotes	.
T12272	48935-49176	sentence	denotes	RXRβ3 cDNA was cloned into pET 28C(+) (Invitrogen, Carlsbad, CA, USA) and protein synthesized by TNT quick coupled transcription/translation system kit (Promega) and radiolabeled with 35S methionine according to manufacturer's instructions.
T12273	48936-48941	NN	denotes	RXRβ3
T12274	48942-48946	NN	denotes	cDNA
T12275	48951-48957	VBN	denotes	cloned
T12276	48947-48950	VBD	denotes	was
T12277	48958-48962	IN	denotes	into
T12278	48963-48966	NN	denotes	pET
T12279	48967-48970	NN	denotes	28C
T12280	48970-48971	-LRB-	denotes	(
T12281	48971-48972	SYM	denotes	+
T12282	48972-48973	-RRB-	denotes	)
T12283	48974-48975	-LRB-	denotes	(
T12284	48975-48985	NNP	denotes	Invitrogen
T12285	48985-48987	,	denotes	,
T12286	48987-48995	NNP	denotes	Carlsbad
T12287	48995-48997	,	denotes	,
T12288	48997-48999	NNP	denotes	CA
T12289	48999-49001	,	denotes	,
T12290	49001-49004	NNP	denotes	USA
T12291	49004-49005	-RRB-	denotes	)
T12292	49006-49009	CC	denotes	and
T12293	49010-49017	NN	denotes	protein
T12294	49018-49029	VBN	denotes	synthesized
T12295	49030-49032	IN	denotes	by
T12296	49033-49036	NN	denotes	TNT
T12297	49084-49087	NN	denotes	kit
T12298	49037-49042	RB	denotes	quick
T12299	49043-49050	VBN	denotes	coupled
T12300	49051-49064	NN	denotes	transcription
T12301	49065-49076	NN	denotes	translation
T12302	49064-49065	HYPH	denotes	/
T12303	49077-49083	NN	denotes	system
T12304	49088-49089	-LRB-	denotes	(
T12305	49089-49096	NNP	denotes	Promega
T12306	49096-49097	-RRB-	denotes	)
T12307	49098-49101	CC	denotes	and
T12308	49102-49114	VBN	denotes	radiolabeled
T12309	49115-49119	IN	denotes	with
T12310	49120-49123	NN	denotes	35S
T12311	49124-49134	NN	denotes	methionine
T12312	49135-49144	VBG	denotes	according
T12313	49145-49147	IN	denotes	to
T12314	49148-49160	NN	denotes	manufacturer
T12315	49163-49175	NNS	denotes	instructions
T12316	49160-49162	POS	denotes	's
T12317	49175-49176	.	denotes	.
T12318	49176-49350	sentence	denotes	100 μl of in vitro translated RXRβ3 protein in 1 ml of 20 mM Tris-HCl pH.8.0, 200 mM NaCl, 1 mM EDTA pH8.0 was incubated at 4°C with immobilized GST-TACC2 or GST for 90 min.
T12319	49177-49180	CD	denotes	100
T12320	49181-49183	NN	denotes	μl
T12321	49288-49297	VBN	denotes	incubated
T12322	49184-49186	IN	denotes	of
T12323	49187-49189	FW	denotes	in
T12324	49190-49195	FW	denotes	vitro
T12325	49196-49206	VBN	denotes	translated
T12326	49213-49220	NN	denotes	protein
T12327	49207-49212	NN	denotes	RXRβ3
T12328	49221-49223	IN	denotes	in
T12329	49224-49225	CD	denotes	1
T12330	49226-49228	NN	denotes	ml
T12331	49229-49231	IN	denotes	of
T12332	49232-49234	CD	denotes	20
T12333	49235-49237	NN	denotes	mM
T12334	49243-49246	NN	denotes	HCl
T12335	49238-49242	NN	denotes	Tris
T12336	49242-49243	HYPH	denotes	-
T12337	49247-49253	NN	denotes	pH.8.0
T12338	49253-49255	,	denotes	,
T12339	49255-49258	CD	denotes	200
T12340	49259-49261	NN	denotes	mM
T12341	49262-49266	NN	denotes	NaCl
T12342	49266-49268	,	denotes	,
T12343	49268-49269	CD	denotes	1
T12344	49270-49272	NN	denotes	mM
T12345	49273-49277	NN	denotes	EDTA
T12346	49278-49283	NN	denotes	pH8.0
T12347	49284-49287	VBD	denotes	was
T12348	49298-49300	IN	denotes	at
T12349	49301-49302	CD	denotes	4
T12350	49302-49304	NN	denotes	°C
T12351	49305-49309	IN	denotes	with
T12352	49310-49321	VBN	denotes	immobilized
T12353	49326-49331	NN	denotes	TACC2
T12354	49322-49325	NN	denotes	GST
T12355	49325-49326	HYPH	denotes	-
T12356	49332-49334	CC	denotes	or
T12357	49335-49338	NN	denotes	GST
T12358	49339-49342	IN	denotes	for
T12359	49343-49345	CD	denotes	90
T12360	49346-49349	NN	denotes	min
T12361	49349-49350	.	denotes	.
T12362	49350-49457	sentence	denotes	Unbound RXRβ3 was removed by washing three times with 20 mM Tris-HCl pH.8.0, 200 mM NaCl, 1 mM EDTA pH8.0.
T12363	49351-49358	JJ	denotes	Unbound
T12364	49359-49364	NN	denotes	RXRβ3
T12365	49369-49376	VBN	denotes	removed
T12366	49365-49368	VBD	denotes	was
T12367	49377-49379	IN	denotes	by
T12368	49380-49387	VBG	denotes	washing
T12369	49388-49393	CD	denotes	three
T12370	49394-49399	NNS	denotes	times
T12371	49400-49404	IN	denotes	with
T12372	49405-49407	CD	denotes	20
T12373	49408-49410	NN	denotes	mM
T12374	49416-49419	NN	denotes	HCl
T12375	49411-49415	NN	denotes	Tris
T12376	49415-49416	HYPH	denotes	-
T12377	49420-49426	NN	denotes	pH.8.0
T12378	49426-49428	,	denotes	,
T12379	49428-49431	CD	denotes	200
T12380	49432-49434	NN	denotes	mM
T12381	49435-49439	NN	denotes	NaCl
T12382	49439-49441	,	denotes	,
T12383	49441-49442	CD	denotes	1
T12384	49443-49445	NN	denotes	mM
T12385	49446-49450	NN	denotes	EDTA
T12386	49451-49456	NN	denotes	pH8.0
T12387	49456-49457	.	denotes	.
T12388	49457-49601	sentence	denotes	Bound proteins were eluted from the beads at room temperature for 10 min in elution buffer (100 mM Tris HCl, pH8.0, 20 mM reduced glutathione).
T12389	49458-49463	NN	denotes	Bound
T12390	49464-49472	NN	denotes	proteins
T12391	49478-49484	VBN	denotes	eluted
T12392	49473-49477	VBD	denotes	were
T12393	49485-49489	IN	denotes	from
T12394	49490-49493	DT	denotes	the
T12395	49494-49499	NNS	denotes	beads
T12396	49500-49502	IN	denotes	at
T12397	49503-49507	NN	denotes	room
T12398	49508-49519	NN	denotes	temperature
T12399	49520-49523	IN	denotes	for
T12400	49524-49526	CD	denotes	10
T12401	49527-49530	NN	denotes	min
T12402	49531-49533	IN	denotes	in
T12403	49534-49541	NN	denotes	elution
T12404	49542-49548	NN	denotes	buffer
T12405	49549-49550	-LRB-	denotes	(
T12406	49562-49565	NN	denotes	HCl
T12407	49550-49553	CD	denotes	100
T12408	49554-49556	NN	denotes	mM
T12409	49557-49561	NN	denotes	Tris
T12410	49565-49567	,	denotes	,
T12411	49567-49572	NN	denotes	pH8.0
T12412	49572-49574	,	denotes	,
T12413	49574-49576	CD	denotes	20
T12414	49577-49579	NN	denotes	mM
T12415	49588-49599	NN	denotes	glutathione
T12416	49580-49587	VBN	denotes	reduced
T12417	49599-49600	-RRB-	denotes	)
T12418	49600-49601	.	denotes	.
T12419	49601-49660	sentence	denotes	The proteins were analyzed on 12% SDS polyacrylamide gels.
T12420	49602-49605	DT	denotes	The
T12421	49606-49614	NN	denotes	proteins
T12422	49620-49628	VBN	denotes	analyzed
T12423	49615-49619	VBD	denotes	were
T12424	49629-49631	IN	denotes	on
T12425	49632-49634	CD	denotes	12
T12426	49634-49635	NN	denotes	%
T12427	49655-49659	NNS	denotes	gels
T12428	49636-49639	NN	denotes	SDS
T12429	49640-49654	NN	denotes	polyacrylamide
T12430	49659-49660	.	denotes	.
T12431	49660-49730	sentence	denotes	Coomassie blue staining verified equal loading of GST fusion protein.
T12432	49661-49670	NNP	denotes	Coomassie
T12433	49676-49684	NN	denotes	staining
T12434	49671-49675	JJ	denotes	blue
T12435	49685-49693	VBD	denotes	verified
T12436	49694-49699	JJ	denotes	equal
T12437	49700-49707	NN	denotes	loading
T12438	49708-49710	IN	denotes	of
T12439	49711-49714	NN	denotes	GST
T12440	49722-49729	NN	denotes	protein
T12441	49715-49721	NN	denotes	fusion
T12442	49729-49730	.	denotes	.
T12443	49730-49764	sentence	denotes	Dried gels were autoradiographed.
T12444	49731-49736	VBN	denotes	Dried
T12445	49737-49741	NNS	denotes	gels
T12446	49747-49763	VBN	denotes	autoradiographed
T12447	49742-49746	VBD	denotes	were
T12448	49763-49764	.	denotes	.
T12469	6237-6249	JJ	denotes	Phylogenetic
T12470	6250-6258	NN	denotes	analysis
T12471	6259-6261	IN	denotes	of
T12472	6262-6265	DT	denotes	the
T12473	6278-6285	NNS	denotes	members
T12474	6266-6270	NN	denotes	TACC
T12475	6271-6277	NN	denotes	family
T12476	6286-6294	VBN	denotes	compared
T12477	6295-6297	IN	denotes	to
T12478	6298-6303	JJ	denotes	other
T12479	6316-6324	NN	denotes	proteins
T12480	6304-6310	VBN	denotes	coiled
T12481	6311-6315	NN	denotes	coil
T12482	6324-6325	.	denotes	.
T12483	6325-6400	sentence	denotes	The phylogenetic tree was constructed as described in the Methods section.
T12484	6326-6329	DT	denotes	The
T12485	6343-6347	NN	denotes	tree
T12486	6330-6342	JJ	denotes	phylogenetic
T12487	6352-6363	VBN	denotes	constructed
T12488	6348-6351	VBD	denotes	was
T12489	6364-6366	IN	denotes	as
T12490	6367-6376	VBN	denotes	described
T12491	6377-6379	IN	denotes	in
T12492	6380-6383	DT	denotes	the
T12493	6392-6399	NN	denotes	section
T12494	6384-6391	NNS	denotes	Methods
T12495	6399-6400	.	denotes	.
T12496	6400-6568	sentence	denotes	The TACC family defines a separate subfamily of coiled coil containing proteins, distinct from other coiled coil families such as the keratins, RHAMM and tropomyosins.
T12497	6401-6404	DT	denotes	The
T12498	6410-6416	NN	denotes	family
T12499	6405-6409	NN	denotes	TACC
T12500	6417-6424	VBZ	denotes	defines
T12501	6425-6426	DT	denotes	a
T12502	6436-6445	NN	denotes	subfamily
T12503	6427-6435	JJ	denotes	separate
T12504	6446-6448	IN	denotes	of
T12505	6449-6455	VBN	denotes	coiled
T12506	6456-6460	NN	denotes	coil
T12507	6461-6471	VBG	denotes	containing
T12508	6472-6480	NN	denotes	proteins
T12509	6480-6482	,	denotes	,
T12510	6482-6490	JJ	denotes	distinct
T12511	6491-6495	IN	denotes	from
T12512	6496-6501	JJ	denotes	other
T12513	6514-6522	NNS	denotes	families
T12514	6502-6508	VBN	denotes	coiled
T12515	6509-6513	NN	denotes	coil
T12516	6523-6527	JJ	denotes	such
T12517	6528-6530	IN	denotes	as
T12518	6531-6534	DT	denotes	the
T12519	6535-6543	NNS	denotes	keratins
T12520	6543-6545	,	denotes	,
T12521	6545-6550	NN	denotes	RHAMM
T12522	6551-6554	CC	denotes	and
T12523	6555-6567	NNS	denotes	tropomyosins
T12524	6567-6568	.	denotes	.
T12525	6568-6718	sentence	denotes	Note that the RHAMM proteins form a separate branch more closely related to the tropomyosins and kinesin like proteins (KLP), than the TACC proteins.
T12526	6569-6573	VB	denotes	Note
T12527	6574-6578	IN	denotes	that
T12528	6598-6602	VBP	denotes	form
T12529	6579-6582	DT	denotes	the
T12530	6589-6597	NN	denotes	proteins
T12531	6583-6588	NN	denotes	RHAMM
T12532	6603-6604	DT	denotes	a
T12533	6614-6620	NN	denotes	branch
T12534	6605-6613	JJ	denotes	separate
T12535	6621-6625	RBR	denotes	more
T12536	6626-6633	RB	denotes	closely
T12537	6634-6641	JJ	denotes	related
T12538	6642-6644	IN	denotes	to
T12539	6645-6648	DT	denotes	the
T12540	6649-6661	NNS	denotes	tropomyosins
T12541	6662-6665	CC	denotes	and
T12542	6666-6673	NN	denotes	kinesin
T12543	6674-6678	JJ	denotes	like
T12544	6679-6687	NN	denotes	proteins
T12545	6688-6689	-LRB-	denotes	(
T12546	6689-6692	NN	denotes	KLP
T12547	6692-6693	-RRB-	denotes	)
T12548	6693-6695	,	denotes	,
T12549	6695-6699	IN	denotes	than
T12550	6700-6703	DT	denotes	the
T12551	6709-6717	NN	denotes	proteins
T12552	6704-6708	NN	denotes	TACC
T12553	6717-6718	.	denotes	.
T12611	16182-16188	JJ	denotes	Linear
T12612	16189-16201	NN	denotes	organization
T12613	16202-16204	IN	denotes	of
T12614	16205-16209	NN	denotes	gene
T12615	16210-16218	NNS	denotes	clusters
T12616	16219-16228	VBG	denotes	centering
T12617	16229-16233	IN	denotes	upon
T12618	16234-16237	DT	denotes	the
T12619	16250-16254	NNS	denotes	loci
T12620	16238-16249	JJ	denotes	chromosomal
T12621	16255-16257	IN	denotes	of
T12622	16258-16261	DT	denotes	the
T12623	16267-16272	NNS	denotes	genes
T12624	16262-16266	NN	denotes	FGFR
T12625	16273-16275	IN	denotes	in
T12626	16276-16282	NNS	denotes	humans
T12627	16282-16283	.	denotes	.
T12628	16283-16570	sentence	denotes	Paralogous genes present in at least two of the four loci are shown, with the exception of the region between GPX3 and NKX2E on chromosome 5, which appears to represent a series of intervening genes inserted after duplication of the 4p16/5q32-35 clusters, and genes mentioned in Fig. 3.
T12629	16284-16294	JJ	denotes	Paralogous
T12630	16295-16300	NNS	denotes	genes
T12631	16346-16351	VBN	denotes	shown
T12632	16301-16308	JJ	denotes	present
T12633	16309-16311	IN	denotes	in
T12634	16312-16314	RB	denotes	at
T12635	16321-16324	CD	denotes	two
T12636	16315-16320	RBS	denotes	least
T12637	16325-16327	IN	denotes	of
T12638	16328-16331	DT	denotes	the
T12639	16337-16341	NNS	denotes	loci
T12640	16332-16336	CD	denotes	four
T12641	16342-16345	VBP	denotes	are
T12642	16351-16353	,	denotes	,
T12643	16353-16357	IN	denotes	with
T12644	16358-16361	DT	denotes	the
T12645	16362-16371	NN	denotes	exception
T12646	16372-16374	IN	denotes	of
T12647	16375-16378	DT	denotes	the
T12648	16379-16385	NN	denotes	region
T12649	16386-16393	IN	denotes	between
T12650	16394-16398	NN	denotes	GPX3
T12651	16399-16402	CC	denotes	and
T12652	16403-16408	NN	denotes	NKX2E
T12653	16409-16411	IN	denotes	on
T12654	16412-16422	NN	denotes	chromosome
T12655	16423-16424	CD	denotes	5
T12656	16424-16426	,	denotes	,
T12657	16426-16431	WDT	denotes	which
T12658	16432-16439	VBZ	denotes	appears
T12659	16440-16442	TO	denotes	to
T12660	16443-16452	VB	denotes	represent
T12661	16453-16454	DT	denotes	a
T12662	16455-16461	NN	denotes	series
T12663	16462-16464	IN	denotes	of
T12664	16465-16476	VBG	denotes	intervening
T12665	16477-16482	NNS	denotes	genes
T12666	16483-16491	VBN	denotes	inserted
T12667	16492-16497	IN	denotes	after
T12668	16498-16509	NN	denotes	duplication
T12669	16510-16512	IN	denotes	of
T12670	16513-16516	DT	denotes	the
T12671	16530-16538	NNS	denotes	clusters
T12672	16517-16521	NN	denotes	4p16
T12673	16522-16526	NN	denotes	5q32
T12674	16521-16522	HYPH	denotes	/
T12675	16526-16527	HYPH	denotes	-
T12676	16527-16529	CD	denotes	35
T12677	16538-16540	,	denotes	,
T12678	16540-16543	CC	denotes	and
T12679	16544-16549	NNS	denotes	genes
T12680	16550-16559	VBN	denotes	mentioned
T12681	16560-16562	IN	denotes	in
T12682	16563-16567	NN	denotes	Fig.
T12683	16568-16569	CD	denotes	3
T12684	16569-16570	.	denotes	.
T12685	16570-16640	sentence	denotes	Corresponding syntenic mouse chromosomal regions (mm*) are indicated.
T12686	16571-16584	VBG	denotes	Corresponding
T12687	16612-16619	NNS	denotes	regions
T12688	16585-16593	JJ	denotes	syntenic
T12689	16594-16599	NN	denotes	mouse
T12690	16600-16611	JJ	denotes	chromosomal
T12691	16630-16639	VBN	denotes	indicated
T12692	16620-16621	-LRB-	denotes	(
T12693	16621-16623	NNP	denotes	mm
T12694	16623-16624	SYM	denotes	*
T12695	16624-16625	-RRB-	denotes	)
T12696	16626-16629	VBP	denotes	are
T12697	16639-16640	.	denotes	.
T12698	16640-16748	sentence	denotes	Takifugu rubripes scaffolds are shown (TR*) that contain more than one homologous gene from these clusters.
T12699	16641-16649	NNP	denotes	Takifugu
T12700	16650-16658	NNP	denotes	rubripes
T12701	16659-16668	NNS	denotes	scaffolds
T12702	16673-16678	VBN	denotes	shown
T12703	16669-16672	VBP	denotes	are
T12704	16679-16680	-LRB-	denotes	(
T12705	16680-16682	NN	denotes	TR
T12706	16682-16683	SYM	denotes	*
T12707	16683-16684	-RRB-	denotes	)
T12708	16685-16689	WDT	denotes	that
T12709	16690-16697	VBP	denotes	contain
T12710	16698-16702	JJR	denotes	more
T12711	16708-16711	CD	denotes	one
T12712	16703-16707	IN	denotes	than
T12713	16723-16727	NN	denotes	gene
T12714	16712-16722	JJ	denotes	homologous
T12715	16728-16732	IN	denotes	from
T12716	16733-16738	DT	denotes	these
T12717	16739-16747	NNS	denotes	clusters
T12718	16747-16748	.	denotes	.
T12719	16748-16841	sentence	denotes	Further details on the location of paralogous genes can be found in [see Additional file 1].
T12720	16749-16756	JJ	denotes	Further
T12721	16757-16764	NNS	denotes	details
T12722	16808-16813	VBN	denotes	found
T12723	16765-16767	IN	denotes	on
T12724	16768-16771	DT	denotes	the
T12725	16772-16780	NN	denotes	location
T12726	16781-16783	IN	denotes	of
T12727	16784-16794	JJ	denotes	paralogous
T12728	16795-16800	NNS	denotes	genes
T12729	16801-16804	MD	denotes	can
T12730	16805-16807	VB	denotes	be
T12731	16814-16816	IN	denotes	in
T12732	16817-16818	-LRB-	denotes	[
T12733	16818-16821	VB	denotes	see
T12734	16822-16832	JJ	denotes	Additional
T12735	16833-16837	NN	denotes	file
T12736	16838-16839	CD	denotes	1
T12737	16839-16840	-RRB-	denotes	]
T12738	16840-16841	.	denotes	.
T12814	20784-20793	NN	denotes	Formation
T12815	20794-20796	IN	denotes	of
T12816	20797-20810	NNS	denotes	protoclusters
T12817	20811-20813	IN	denotes	in
T12818	20814-20822	NNP	denotes	Takifugu
T12819	20823-20831	NNP	denotes	rubripes
T12820	20832-20835	CC	denotes	and
T12821	20836-20841	NNP	denotes	Ciona
T12822	20842-20854	NNP	denotes	intestinalis
T12823	20854-20856	:	denotes	:
T12824	20856-20857	-LRB-	denotes	(
T12825	20857-20858	LS	denotes	A
T12826	20856-20957	sentence	denotes	(A): Structure of the genomic scaffolds containing the Takifugu rubripes trTACC1A and trTACC1B genes.
T12827	20861-20870	NN	denotes	Structure
T12828	20858-20859	-RRB-	denotes	)
T12829	20859-20861	:	denotes	:
T12830	20871-20873	IN	denotes	of
T12831	20874-20877	DT	denotes	the
T12832	20886-20895	NNS	denotes	scaffolds
T12833	20878-20885	JJ	denotes	genomic
T12834	20896-20906	VBG	denotes	containing
T12835	20907-20910	DT	denotes	the
T12836	20951-20956	NNS	denotes	genes
T12837	20911-20919	NNP	denotes	Takifugu
T12838	20920-20928	NNS	denotes	rubripes
T12839	20929-20937	NN	denotes	trTACC1A
T12840	20938-20941	CC	denotes	and
T12841	20942-20950	NN	denotes	trTACC1B
T12842	20956-20957	.	denotes	.
T12843	20957-21116	sentence	denotes	Scaffold 12, the site for the trTACC1A gene contains genes found with either homologues or orthologues on the distal long arm of human chromosome 10 and 4p16.
T12844	20958-20966	NN	denotes	Scaffold
T12845	21002-21010	VBZ	denotes	contains
T12846	20967-20969	CD	denotes	12
T12847	20969-20971	,	denotes	,
T12848	20971-20974	DT	denotes	the
T12849	20975-20979	NN	denotes	site
T12850	20980-20983	IN	denotes	for
T12851	20984-20987	DT	denotes	the
T12852	20997-21001	NN	denotes	gene
T12853	20988-20996	NN	denotes	trTACC1A
T12854	21011-21016	NNS	denotes	genes
T12855	21017-21022	VBN	denotes	found
T12856	21023-21027	IN	denotes	with
T12857	21028-21034	CC	denotes	either
T12858	21035-21045	NNS	denotes	homologues
T12859	21046-21048	CC	denotes	or
T12860	21049-21060	NNS	denotes	orthologues
T12861	21061-21063	IN	denotes	on
T12862	21064-21067	DT	denotes	the
T12863	21080-21083	NN	denotes	arm
T12864	21068-21074	JJ	denotes	distal
T12865	21075-21079	JJ	denotes	long
T12866	21084-21086	IN	denotes	of
T12867	21087-21092	JJ	denotes	human
T12868	21111-21115	NN	denotes	4p16
T12869	21093-21103	NN	denotes	chromosome
T12870	21104-21106	CD	denotes	10
T12871	21107-21110	CC	denotes	and
T12872	21115-21116	.	denotes	.
T12873	21116-21250	sentence	denotes	This scaffold, therefore, has some of the characteristics of the predicted immediate ancestor of the TACC1/TACC2 chromosomal segment.
T12874	21117-21121	DT	denotes	This
T12875	21122-21130	NN	denotes	scaffold
T12876	21143-21146	VBZ	denotes	has
T12877	21130-21132	,	denotes	,
T12878	21132-21141	RB	denotes	therefore
T12879	21141-21143	,	denotes	,
T12880	21147-21151	DT	denotes	some
T12881	21152-21154	IN	denotes	of
T12882	21155-21158	DT	denotes	the
T12883	21159-21174	NNS	denotes	characteristics
T12884	21175-21177	IN	denotes	of
T12885	21178-21181	DT	denotes	the
T12886	21202-21210	NN	denotes	ancestor
T12887	21182-21191	VBN	denotes	predicted
T12888	21192-21201	JJ	denotes	immediate
T12889	21211-21213	IN	denotes	of
T12890	21214-21217	DT	denotes	the
T12891	21242-21249	NN	denotes	segment
T12892	21218-21223	NN	denotes	TACC1
T12893	21224-21229	NN	denotes	TACC2
T12894	21223-21224	HYPH	denotes	/
T12895	21230-21241	JJ	denotes	chromosomal
T12896	21249-21250	.	denotes	.
T12897	21250-21376	sentence	denotes	trTACC1B is found on scaffold 191, which contains orthologues of genes found in the proximal short arm of human chromosome 8.
T12898	21251-21259	NN	denotes	trTACC1B
T12899	21263-21268	VBN	denotes	found
T12900	21260-21262	VBZ	denotes	is
T12901	21269-21271	IN	denotes	on
T12902	21272-21280	NN	denotes	scaffold
T12903	21281-21284	CD	denotes	191
T12904	21284-21286	,	denotes	,
T12905	21286-21291	WDT	denotes	which
T12906	21292-21300	VBZ	denotes	contains
T12907	21301-21312	NNS	denotes	orthologues
T12908	21313-21315	IN	denotes	of
T12909	21316-21321	NNS	denotes	genes
T12910	21322-21327	VBN	denotes	found
T12911	21328-21330	IN	denotes	in
T12912	21331-21334	DT	denotes	the
T12913	21350-21353	NN	denotes	arm
T12914	21335-21343	JJ	denotes	proximal
T12915	21344-21349	JJ	denotes	short
T12916	21354-21356	IN	denotes	of
T12917	21357-21362	JJ	denotes	human
T12918	21363-21373	NN	denotes	chromosome
T12919	21374-21375	CD	denotes	8
T12920	21375-21376	.	denotes	.
T12921	21376-21485	sentence	denotes	(B): Ciona intestinalis clusters containing genes found in paralogous segments on human 8, 4p16, 10q and 5q.
T12922	21377-21378	-LRB-	denotes	(
T12923	21378-21379	LS	denotes	B
T12924	21401-21409	NNS	denotes	clusters
T12925	21379-21380	-RRB-	denotes	)
T12926	21380-21382	:	denotes	:
T12927	21382-21387	NNP	denotes	Ciona
T12928	21388-21400	NNP	denotes	intestinalis
T12929	21410-21420	VBG	denotes	containing
T12930	21421-21426	NNS	denotes	genes
T12931	21427-21432	VBN	denotes	found
T12932	21433-21435	IN	denotes	in
T12933	21436-21446	JJ	denotes	paralogous
T12934	21447-21455	NNS	denotes	segments
T12935	21456-21458	IN	denotes	on
T12936	21459-21464	JJ	denotes	human
T12937	21468-21472	NN	denotes	4p16
T12938	21465-21466	CD	denotes	8
T12939	21466-21468	,	denotes	,
T12940	21472-21474	,	denotes	,
T12941	21474-21477	NN	denotes	10q
T12942	21478-21481	CC	denotes	and
T12943	21482-21484	NN	denotes	5q
T12944	21484-21485	.	denotes	.
T12994	21496-21503	JJ	denotes	Genomic
T12995	21504-21513	NN	denotes	structure
T12996	21514-21516	IN	denotes	of
T12997	21517-21520	DT	denotes	the
T12998	21526-21531	NNS	denotes	genes
T12999	21521-21525	NN	denotes	TACC
T13000	21531-21532	.	denotes	.
T13001	21532-21618	sentence	denotes	Conserved regions known to bind protein factors in all human TACC proteins are shown.
T13002	21533-21542	VBN	denotes	Conserved
T13003	21543-21550	NNS	denotes	regions
T13004	21612-21617	VBN	denotes	shown
T13005	21551-21556	VBN	denotes	known
T13006	21557-21559	TO	denotes	to
T13007	21560-21564	VB	denotes	bind
T13008	21565-21572	NN	denotes	protein
T13009	21573-21580	NNS	denotes	factors
T13010	21581-21583	IN	denotes	in
T13011	21584-21587	DT	denotes	all
T13012	21599-21607	NN	denotes	proteins
T13013	21588-21593	JJ	denotes	human
T13014	21594-21598	NN	denotes	TACC
T13015	21608-21611	VBP	denotes	are
T13016	21617-21618	.	denotes	.
T13017	21618-21702	sentence	denotes	The SDP repeat of human TACC1-3 is known to bind GAS41 ([3,15] and data not shown).
T13018	21619-21622	DT	denotes	The
T13019	21627-21633	NN	denotes	repeat
T13020	21623-21626	NN	denotes	SDP
T13021	21654-21659	VBN	denotes	known
T13022	21634-21636	IN	denotes	of
T13023	21637-21642	JJ	denotes	human
T13024	21643-21648	NN	denotes	TACC1
T13025	21648-21649	HYPH	denotes	-
T13026	21649-21650	CD	denotes	3
T13027	21651-21653	VBZ	denotes	is
T13028	21660-21662	TO	denotes	to
T13029	21663-21667	VB	denotes	bind
T13030	21668-21673	NN	denotes	GAS41
T13031	21674-21675	-LRB-	denotes	(
T13032	21678-21680	CD	denotes	15
T13033	21675-21676	-LRB-	denotes	[
T13034	21676-21677	CD	denotes	3
T13035	21677-21678	,	denotes	,
T13036	21680-21681	-RRB-	denotes	]
T13037	21682-21685	CC	denotes	and
T13038	21686-21690	NNS	denotes	data
T13039	21695-21700	VBN	denotes	shown
T13040	21691-21694	RB	denotes	not
T13041	21700-21701	-RRB-	denotes	)
T13042	21701-21702	.	denotes	.
T13043	21702-21798	sentence	denotes	The TACC domain binds ch-TOG and members of the Aurora kinases in all species examined to date.
T13044	21703-21706	DT	denotes	The
T13045	21712-21718	NN	denotes	domain
T13046	21707-21711	NN	denotes	TACC
T13047	21719-21724	VBZ	denotes	binds
T13048	21725-21727	NN	denotes	ch
T13049	21728-21731	NN	denotes	TOG
T13050	21727-21728	HYPH	denotes	-
T13051	21732-21735	CC	denotes	and
T13052	21736-21743	NNS	denotes	members
T13053	21744-21746	IN	denotes	of
T13054	21747-21750	DT	denotes	the
T13055	21758-21765	NNS	denotes	kinases
T13056	21751-21757	NNP	denotes	Aurora
T13057	21766-21768	IN	denotes	in
T13058	21769-21772	DT	denotes	all
T13059	21773-21780	NNS	denotes	species
T13060	21781-21789	VBN	denotes	examined
T13061	21790-21792	IN	denotes	to
T13062	21793-21797	NN	denotes	date
T13063	21797-21798	.	denotes	.
T13064	21798-21874	sentence	denotes	This motif is characteristically encoded by the 3' exons of the TACC genes.
T13065	21799-21803	DT	denotes	This
T13066	21804-21809	NN	denotes	motif
T13067	21832-21839	VBN	denotes	encoded
T13068	21810-21812	VBZ	denotes	is
T13069	21813-21831	RB	denotes	characteristically
T13070	21840-21842	IN	denotes	by
T13071	21843-21846	DT	denotes	the
T13072	21850-21855	NNS	denotes	exons
T13073	21847-21848	CD	denotes	3
T13074	21848-21849	SYM	denotes	'
T13075	21856-21858	IN	denotes	of
T13076	21859-21862	DT	denotes	the
T13077	21868-21873	NNS	denotes	genes
T13078	21863-21867	NN	denotes	TACC
T13079	21873-21874	.	denotes	.
T13080	21874-21930	sentence	denotes	The size of the largest isoform for each gene is shown.
T13081	21875-21878	DT	denotes	The
T13082	21879-21883	NN	denotes	size
T13083	21924-21929	VBN	denotes	shown
T13084	21884-21886	IN	denotes	of
T13085	21887-21890	DT	denotes	the
T13086	21899-21906	NN	denotes	isoform
T13087	21891-21898	JJS	denotes	largest
T13088	21907-21910	IN	denotes	for
T13089	21911-21915	DT	denotes	each
T13090	21916-21920	NN	denotes	gene
T13091	21921-21923	VBZ	denotes	is
T13092	21929-21930	.	denotes	.
T13211	27467-27478	JJ	denotes	Alternative
T13212	27479-27487	NN	denotes	splicing
T13213	27488-27490	IN	denotes	of
T13214	27491-27494	DT	denotes	the
T13215	27507-27511	NN	denotes	gene
T13216	27495-27500	JJ	denotes	human
T13217	27501-27506	NN	denotes	TACC1
T13218	27511-27512	.	denotes	.
T13219	27512-27589	sentence	denotes	(A): Seven splice variants have been identified for human TACC1 (A-F and S).
T13220	27513-27514	-LRB-	denotes	(
T13221	27514-27515	LS	denotes	A
T13222	27550-27560	VBN	denotes	identified
T13223	27515-27516	-RRB-	denotes	)
T13224	27516-27518	:	denotes	:
T13225	27518-27523	CD	denotes	Seven
T13226	27531-27539	NNS	denotes	variants
T13227	27524-27530	NN	denotes	splice
T13228	27540-27544	VBP	denotes	have
T13229	27545-27549	VBN	denotes	been
T13230	27561-27564	IN	denotes	for
T13231	27565-27570	JJ	denotes	human
T13232	27571-27576	NN	denotes	TACC1
T13233	27577-27578	-LRB-	denotes	(
T13234	27578-27579	NN	denotes	A
T13235	27579-27580	SYM	denotes	-
T13236	27580-27581	NN	denotes	F
T13237	27582-27585	CC	denotes	and
T13238	27586-27587	NN	denotes	S
T13239	27587-27588	-RRB-	denotes	)
T13240	27588-27589	.	denotes	.
T13241	27589-27709	sentence	denotes	We have also identified additional splice variants (G-I) from database analysis and rt-PCR analysis of human brain RNA.
T13242	27590-27592	PRP	denotes	We
T13243	27603-27613	VBN	denotes	identified
T13244	27593-27597	VBP	denotes	have
T13245	27598-27602	RB	denotes	also
T13246	27614-27624	JJ	denotes	additional
T13247	27632-27640	NNS	denotes	variants
T13248	27625-27631	NN	denotes	splice
T13249	27641-27642	-LRB-	denotes	(
T13250	27642-27643	NN	denotes	G
T13251	27643-27644	SYM	denotes	-
T13252	27644-27645	NN	denotes	I
T13253	27645-27646	-RRB-	denotes	)
T13254	27647-27651	IN	denotes	from
T13255	27652-27660	NN	denotes	database
T13256	27661-27669	NN	denotes	analysis
T13257	27670-27673	CC	denotes	and
T13258	27674-27676	NN	denotes	rt
T13259	27677-27680	NN	denotes	PCR
T13260	27676-27677	HYPH	denotes	-
T13261	27681-27689	NN	denotes	analysis
T13262	27690-27692	IN	denotes	of
T13263	27693-27698	JJ	denotes	human
T13264	27699-27704	NN	denotes	brain
T13265	27705-27708	NN	denotes	RNA
T13266	27708-27709	.	denotes	.
T13267	27709-27764	sentence	denotes	(B): Alternative splicing of TACC1 in the human brain.
T13268	27710-27711	-LRB-	denotes	(
T13269	27711-27712	LS	denotes	B
T13270	27727-27735	NN	denotes	splicing
T13271	27712-27713	-RRB-	denotes	)
T13272	27713-27715	:	denotes	:
T13273	27715-27726	JJ	denotes	Alternative
T13274	27736-27738	IN	denotes	of
T13275	27739-27744	NN	denotes	TACC1
T13276	27745-27747	IN	denotes	in
T13277	27748-27751	DT	denotes	the
T13278	27758-27763	NN	denotes	brain
T13279	27752-27757	JJ	denotes	human
T13280	27763-27764	.	denotes	.
T13281	27764-27939	sentence	denotes	rt-PCR analysis confirms splicing of the untranslated exon 1a to exon 1, with retention of the originally defined start methionine (GB:NP_006274) (Variant A*, lanes 1 and 3).
T13282	27765-27767	NN	denotes	rt
T13283	27768-27771	NN	denotes	PCR
T13284	27767-27768	HYPH	denotes	-
T13285	27772-27780	NN	denotes	analysis
T13286	27781-27789	VBZ	denotes	confirms
T13287	27790-27798	NN	denotes	splicing
T13288	27799-27801	IN	denotes	of
T13289	27802-27805	DT	denotes	the
T13290	27819-27823	NN	denotes	exon
T13291	27806-27818	JJ	denotes	untranslated
T13292	27824-27826	CD	denotes	1a
T13293	27827-27829	IN	denotes	to
T13294	27830-27834	NN	denotes	exon
T13295	27835-27836	CD	denotes	1
T13296	27836-27838	,	denotes	,
T13297	27838-27842	IN	denotes	with
T13298	27843-27852	NN	denotes	retention
T13299	27853-27855	IN	denotes	of
T13300	27856-27859	DT	denotes	the
T13301	27885-27895	NN	denotes	methionine
T13302	27860-27870	RB	denotes	originally
T13303	27871-27878	VBN	denotes	defined
T13304	27879-27884	NN	denotes	start
T13305	27896-27897	-LRB-	denotes	(
T13306	27900-27909	NN	denotes	NP_006274
T13307	27897-27899	NN	denotes	GB
T13308	27899-27900	:	denotes	:
T13309	27909-27910	-RRB-	denotes	)
T13310	27911-27912	-LRB-	denotes	(
T13311	27930-27931	CD	denotes	1
T13312	27912-27919	NN	denotes	Variant
T13313	27920-27921	NN	denotes	A
T13314	27921-27922	SYM	denotes	*
T13315	27922-27924	,	denotes	,
T13316	27924-27929	NNS	denotes	lanes
T13317	27932-27935	CC	denotes	and
T13318	27936-27937	CD	denotes	3
T13319	27937-27938	-RRB-	denotes	)
T13320	27938-27939	.	denotes	.
T13321	27939-28036	sentence	denotes	Exon 1a also splices to exon 2, removing the L-Sm7 binding motif (variant I, lanes 3,12 and 13).
T13322	27940-27944	NN	denotes	Exon
T13323	27953-27960	VBZ	denotes	splices
T13324	27945-27947	CD	denotes	1a
T13325	27948-27952	RB	denotes	also
T13326	27961-27963	IN	denotes	to
T13327	27964-27968	NN	denotes	exon
T13328	27969-27970	CD	denotes	2
T13329	27970-27972	,	denotes	,
T13330	27972-27980	VBG	denotes	removing
T13331	27981-27984	DT	denotes	the
T13332	27999-28004	NN	denotes	motif
T13333	27985-27986	NN	denotes	L
T13334	27987-27990	NN	denotes	Sm7
T13335	27986-27987	HYPH	denotes	-
T13336	27991-27998	NN	denotes	binding
T13337	28005-28006	-LRB-	denotes	(
T13338	28023-28024	CD	denotes	3
T13339	28006-28013	NN	denotes	variant
T13340	28014-28015	NN	denotes	I
T13341	28015-28017	,	denotes	,
T13342	28017-28022	NNS	denotes	lanes
T13343	28024-28025	,	denotes	,
T13344	28025-28027	CD	denotes	12
T13345	28028-28031	CC	denotes	and
T13346	28032-28034	CD	denotes	13
T13347	28034-28035	-RRB-	denotes	)
T13348	28035-28036	.	denotes	.
T13349	28036-28222	sentence	denotes	Variants that functionally delete exons 2 and/or 3, such as variant C (lane 15) also remove the predicted nuclear localization signals, and the binding domains for GAS41 and PCTAIRE2BP.
T13350	28037-28045	NNS	denotes	Variants
T13351	28122-28128	VBP	denotes	remove
T13352	28046-28050	WDT	denotes	that
T13353	28064-28070	VBP	denotes	delete
T13354	28051-28063	RB	denotes	functionally
T13355	28071-28076	NNS	denotes	exons
T13356	28077-28078	CD	denotes	2
T13357	28079-28082	CC	denotes	and
T13358	28082-28083	HYPH	denotes	/
T13359	28083-28085	CC	denotes	or
T13360	28086-28087	CD	denotes	3
T13361	28087-28089	,	denotes	,
T13362	28089-28093	JJ	denotes	such
T13363	28094-28096	IN	denotes	as
T13364	28097-28104	NN	denotes	variant
T13365	28105-28106	NN	denotes	C
T13366	28107-28108	-LRB-	denotes	(
T13367	28108-28112	NN	denotes	lane
T13368	28113-28115	CD	denotes	15
T13369	28115-28116	-RRB-	denotes	)
T13370	28117-28121	RB	denotes	also
T13371	28129-28132	DT	denotes	the
T13372	28164-28171	NNS	denotes	signals
T13373	28133-28142	VBN	denotes	predicted
T13374	28143-28150	JJ	denotes	nuclear
T13375	28151-28163	NN	denotes	localization
T13376	28171-28173	,	denotes	,
T13377	28173-28176	CC	denotes	and
T13378	28177-28180	DT	denotes	the
T13379	28189-28196	NNS	denotes	domains
T13380	28181-28188	NN	denotes	binding
T13381	28197-28200	IN	denotes	for
T13382	28201-28206	NN	denotes	GAS41
T13383	28207-28210	CC	denotes	and
T13384	28211-28221	NN	denotes	PCTAIRE2BP
T13385	28221-28222	.	denotes	.
T13386	28222-28352	sentence	denotes	These variants would retain the TACC domain, and therefore the potential to bind to ch-TOG and Aurora A kinase in the centrosome.
T13387	28223-28228	DT	denotes	These
T13388	28229-28237	NNS	denotes	variants
T13389	28244-28250	VB	denotes	retain
T13390	28238-28243	MD	denotes	would
T13391	28251-28254	DT	denotes	the
T13392	28260-28266	NN	denotes	domain
T13393	28255-28259	NN	denotes	TACC
T13394	28266-28268	,	denotes	,
T13395	28268-28271	CC	denotes	and
T13396	28272-28281	RB	denotes	therefore
T13397	28286-28295	NN	denotes	potential
T13398	28282-28285	DT	denotes	the
T13399	28296-28298	TO	denotes	to
T13400	28299-28303	VB	denotes	bind
T13401	28304-28306	IN	denotes	to
T13402	28307-28309	NN	denotes	ch
T13403	28310-28313	NN	denotes	TOG
T13404	28309-28310	HYPH	denotes	-
T13405	28314-28317	CC	denotes	and
T13406	28318-28324	NN	denotes	Aurora
T13407	28325-28326	NN	denotes	A
T13408	28327-28333	NN	denotes	kinase
T13409	28334-28336	IN	denotes	in
T13410	28337-28340	DT	denotes	the
T13411	28341-28351	NN	denotes	centrosome
T13412	28351-28352	.	denotes	.
T13413	28352-28657	sentence	denotes	Lane 1: EF/X1R, Lane 2: EF/BX647R, Lane 3: EF/6SPR, Lane 4: EF/1DR, Lane 5, EF/128R, Lane 6 X3F/X1R, Lane 7: X3F/BX647R, Lane 8: X3F/6SPR, Lane 9: X3F/1DR, Lane 10, X3F/128R, Lane 11: 1DF/X1R, Lane 12: 1DF/BX647R, Lane 13: 1DF/6SPR, Lane 14: 1DF/1DR, Lane 15: 1DF/128R, Lane 16: Biorad 1 kb+ Size ladder.
T13414	28353-28357	NN	denotes	Lane
T13415	28364-28367	NN	denotes	X1R
T13416	28358-28359	CD	denotes	1
T13417	28359-28361	:	denotes	:
T13418	28361-28363	NN	denotes	EF
T13419	28363-28364	HYPH	denotes	/
T13420	28650-28656	NN	denotes	ladder
T13421	28367-28369	,	denotes	,
T13422	28369-28373	NN	denotes	Lane
T13423	28380-28386	NN	denotes	BX647R
T13424	28374-28375	CD	denotes	2
T13425	28375-28377	:	denotes	:
T13426	28377-28379	NN	denotes	EF
T13427	28379-28380	HYPH	denotes	/
T13428	28386-28388	,	denotes	,
T13429	28388-28392	NN	denotes	Lane
T13430	28399-28403	NN	denotes	6SPR
T13431	28393-28394	CD	denotes	3
T13432	28394-28396	:	denotes	:
T13433	28396-28398	NN	denotes	EF
T13434	28398-28399	HYPH	denotes	/
T13435	28403-28405	,	denotes	,
T13436	28405-28409	NN	denotes	Lane
T13437	28416-28419	NN	denotes	1DR
T13438	28410-28411	CD	denotes	4
T13439	28411-28413	:	denotes	:
T13440	28413-28415	NN	denotes	EF
T13441	28415-28416	HYPH	denotes	/
T13442	28419-28421	,	denotes	,
T13443	28421-28425	NN	denotes	Lane
T13444	28432-28436	NN	denotes	128R
T13445	28426-28427	CD	denotes	5
T13446	28427-28429	,	denotes	,
T13447	28429-28431	NN	denotes	EF
T13448	28431-28432	HYPH	denotes	/
T13449	28436-28438	,	denotes	,
T13450	28438-28442	NN	denotes	Lane
T13451	28449-28452	NN	denotes	X1R
T13452	28443-28444	CD	denotes	6
T13453	28445-28448	NN	denotes	X3F
T13454	28448-28449	HYPH	denotes	/
T13455	28452-28454	,	denotes	,
T13456	28454-28458	NN	denotes	Lane
T13457	28466-28472	NN	denotes	BX647R
T13458	28459-28460	CD	denotes	7
T13459	28460-28462	:	denotes	:
T13460	28462-28465	NN	denotes	X3F
T13461	28465-28466	HYPH	denotes	/
T13462	28472-28474	,	denotes	,
T13463	28474-28478	NN	denotes	Lane
T13464	28486-28490	NN	denotes	6SPR
T13465	28479-28480	CD	denotes	8
T13466	28480-28482	:	denotes	:
T13467	28482-28485	NN	denotes	X3F
T13468	28485-28486	HYPH	denotes	/
T13469	28490-28492	,	denotes	,
T13470	28492-28496	NN	denotes	Lane
T13471	28504-28507	NN	denotes	1DR
T13472	28497-28498	CD	denotes	9
T13473	28498-28500	:	denotes	:
T13474	28500-28503	NN	denotes	X3F
T13475	28503-28504	HYPH	denotes	/
T13476	28507-28509	,	denotes	,
T13477	28509-28513	NN	denotes	Lane
T13478	28522-28526	NN	denotes	128R
T13479	28514-28516	CD	denotes	10
T13480	28516-28518	,	denotes	,
T13481	28518-28521	NN	denotes	X3F
T13482	28521-28522	HYPH	denotes	/
T13483	28526-28528	,	denotes	,
T13484	28528-28532	NN	denotes	Lane
T13485	28541-28544	NN	denotes	X1R
T13486	28533-28535	CD	denotes	11
T13487	28535-28537	:	denotes	:
T13488	28537-28540	NN	denotes	1DF
T13489	28540-28541	HYPH	denotes	/
T13490	28544-28546	,	denotes	,
T13491	28546-28550	NN	denotes	Lane
T13492	28559-28565	NN	denotes	BX647R
T13493	28551-28553	CD	denotes	12
T13494	28553-28555	:	denotes	:
T13495	28555-28558	NN	denotes	1DF
T13496	28558-28559	HYPH	denotes	/
T13497	28565-28567	,	denotes	,
T13498	28567-28571	NN	denotes	Lane
T13499	28580-28584	NN	denotes	6SPR
T13500	28572-28574	CD	denotes	13
T13501	28574-28576	:	denotes	:
T13502	28576-28579	NN	denotes	1DF
T13503	28579-28580	HYPH	denotes	/
T13504	28584-28586	,	denotes	,
T13505	28586-28590	NN	denotes	Lane
T13506	28599-28602	NN	denotes	1DR
T13507	28591-28593	CD	denotes	14
T13508	28593-28595	:	denotes	:
T13509	28595-28598	NN	denotes	1DF
T13510	28598-28599	HYPH	denotes	/
T13511	28602-28604	,	denotes	,
T13512	28604-28608	NN	denotes	Lane
T13513	28617-28621	NN	denotes	128R
T13514	28609-28611	CD	denotes	15
T13515	28611-28613	:	denotes	:
T13516	28613-28616	NN	denotes	1DF
T13517	28616-28617	HYPH	denotes	/
T13518	28621-28623	,	denotes	,
T13519	28623-28627	NN	denotes	Lane
T13520	28628-28630	CD	denotes	16
T13521	28630-28632	:	denotes	:
T13522	28632-28638	NNP	denotes	Biorad
T13523	28639-28640	CD	denotes	1
T13524	28641-28644	NN	denotes	kb+
T13525	28645-28649	NN	denotes	Size
T13526	28656-28657	.	denotes	.
T13617	31806-31816	JJ	denotes	Functional
T13618	31817-31826	NN	denotes	evolution
T13619	31827-31829	IN	denotes	of
T13620	31830-31833	DT	denotes	the
T13621	31839-31847	NN	denotes	proteins
T13622	31834-31838	NN	denotes	TACC
T13623	31848-31855	VBN	denotes	modeled
T13624	31856-31858	IN	denotes	in
T13625	31859-31861	NNP	denotes	C.
T13626	31862-31869	NNP	denotes	elegans
T13627	31870-31873	CC	denotes	and
T13628	31874-31876	NNP	denotes	D.
T13629	31877-31889	NNP	denotes	melanogaster
T13630	31889-31890	.	denotes	.
T13631	31890-32018	sentence	denotes	(A). C. elegans interaction map shows empirically defined interactions of ceTAC, and extrapolated interactions defined by [28].
T13632	31891-31892	-LRB-	denotes	(
T13633	31892-31893	LS	denotes	A
T13634	31923-31928	VBZ	denotes	shows
T13635	31893-31894	-RRB-	denotes	)
T13636	31894-31895	.	denotes	.
T13637	31896-31898	NNP	denotes	C.
T13638	31899-31906	NNP	denotes	elegans
T13639	31919-31922	NN	denotes	map
T13640	31907-31918	NN	denotes	interaction
T13641	31929-31940	RB	denotes	empirically
T13642	31941-31948	VBN	denotes	defined
T13643	31949-31961	NNS	denotes	interactions
T13644	31962-31964	IN	denotes	of
T13645	31965-31970	NN	denotes	ceTAC
T13646	31970-31972	,	denotes	,
T13647	31972-31975	CC	denotes	and
T13648	31976-31988	VBN	denotes	extrapolated
T13649	31989-32001	NNS	denotes	interactions
T13650	32002-32009	VBN	denotes	defined
T13651	32010-32012	IN	denotes	by
T13652	32013-32014	-LRB-	denotes	[
T13653	32014-32016	CD	denotes	28
T13654	32016-32017	-RRB-	denotes	]
T13655	32017-32018	.	denotes	.
T13656	32018-32289	sentence	denotes	(B): Using the BIND database [29], DTACC directly binds to TBPH and CG14540, and thus indirectly to chromatin remodeling complexes (SWI/SNF and histone acetyltransferases), DNA damage repair machinery (via RAD23), and RNA splicing, transport and translational machinery.
T13657	32019-32020	-LRB-	denotes	(
T13658	32020-32021	LS	denotes	B
T13659	32069-32074	VBZ	denotes	binds
T13660	32021-32022	-RRB-	denotes	)
T13661	32022-32024	:	denotes	:
T13662	32024-32029	VBG	denotes	Using
T13663	32030-32033	DT	denotes	the
T13664	32039-32047	NN	denotes	database
T13665	32034-32038	NNP	denotes	BIND
T13666	32048-32049	-LRB-	denotes	[
T13667	32049-32051	CD	denotes	29
T13668	32051-32052	-RRB-	denotes	]
T13669	32052-32054	,	denotes	,
T13670	32054-32059	NN	denotes	DTACC
T13671	32060-32068	RB	denotes	directly
T13672	32075-32077	IN	denotes	to
T13673	32078-32082	NN	denotes	TBPH
T13674	32083-32086	CC	denotes	and
T13675	32087-32094	NN	denotes	CG14540
T13676	32094-32096	,	denotes	,
T13677	32096-32099	CC	denotes	and
T13678	32100-32104	RB	denotes	thus
T13679	32105-32115	RB	denotes	indirectly
T13680	32116-32118	IN	denotes	to
T13681	32119-32128	NN	denotes	chromatin
T13682	32129-32139	NN	denotes	remodeling
T13683	32140-32149	NNS	denotes	complexes
T13684	32150-32151	-LRB-	denotes	(
T13685	32151-32154	NN	denotes	SWI
T13686	32155-32158	NN	denotes	SNF
T13687	32154-32155	HYPH	denotes	/
T13688	32159-32162	CC	denotes	and
T13689	32163-32170	NN	denotes	histone
T13690	32171-32189	NNS	denotes	acetyltransferases
T13691	32189-32190	-RRB-	denotes	)
T13692	32190-32192	,	denotes	,
T13693	32192-32195	NN	denotes	DNA
T13694	32196-32202	NN	denotes	damage
T13695	32203-32209	NN	denotes	repair
T13696	32210-32219	NN	denotes	machinery
T13697	32220-32221	-LRB-	denotes	(
T13698	32221-32224	IN	denotes	via
T13699	32225-32230	NN	denotes	RAD23
T13700	32230-32231	-RRB-	denotes	)
T13701	32231-32233	,	denotes	,
T13702	32233-32236	CC	denotes	and
T13703	32237-32240	NN	denotes	RNA
T13704	32241-32249	NN	denotes	splicing
T13705	32279-32288	NN	denotes	machinery
T13706	32249-32251	,	denotes	,
T13707	32251-32260	NN	denotes	transport
T13708	32261-32264	CC	denotes	and
T13709	32265-32278	JJ	denotes	translational
T13710	32288-32289	.	denotes	.
T13711	32289-32433	sentence	denotes	(C): Predicted interaction map for vertebrate TACCs, based upon ceTAC, suggests an indirect interaction with the nuclear hormone receptor RXRβ.
T13712	32290-32291	-LRB-	denotes	(
T13713	32291-32292	LS	denotes	C
T13714	32361-32369	VBZ	denotes	suggests
T13715	32292-32293	-RRB-	denotes	)
T13716	32293-32295	:	denotes	:
T13717	32295-32304	VBN	denotes	Predicted
T13718	32305-32316	NN	denotes	interaction
T13719	32317-32320	NN	denotes	map
T13720	32321-32324	IN	denotes	for
T13721	32325-32335	NN	denotes	vertebrate
T13722	32336-32341	NNS	denotes	TACCs
T13723	32341-32343	,	denotes	,
T13724	32343-32348	VBN	denotes	based
T13725	32349-32353	IN	denotes	upon
T13726	32354-32359	NN	denotes	ceTAC
T13727	32359-32361	,	denotes	,
T13728	32370-32372	DT	denotes	an
T13729	32382-32393	NN	denotes	interaction
T13730	32373-32381	JJ	denotes	indirect
T13731	32394-32398	IN	denotes	with
T13732	32399-32402	DT	denotes	the
T13733	32419-32427	NN	denotes	receptor
T13734	32403-32410	JJ	denotes	nuclear
T13735	32411-32418	NN	denotes	hormone
T13736	32428-32432	NN	denotes	RXRβ
T13737	32432-32433	.	denotes	.
T13738	32433-32634	sentence	denotes	It is also of interest that this predicts a functional interaction with the LDB family, members of which are also found in TACC containing paralogous segments noted in Figs 2, 3 and Additional file 1.
T13739	32434-32436	PRP	denotes	It
T13740	32437-32439	VBZ	denotes	is
T13741	32440-32444	RB	denotes	also
T13742	32445-32447	IN	denotes	of
T13743	32448-32456	NN	denotes	interest
T13744	32457-32461	IN	denotes	that
T13745	32467-32475	VBZ	denotes	predicts
T13746	32462-32466	DT	denotes	this
T13747	32476-32477	DT	denotes	a
T13748	32489-32500	NN	denotes	interaction
T13749	32478-32488	JJ	denotes	functional
T13750	32501-32505	IN	denotes	with
T13751	32506-32509	DT	denotes	the
T13752	32514-32520	NN	denotes	family
T13753	32510-32513	NN	denotes	LDB
T13754	32520-32522	,	denotes	,
T13755	32522-32529	NNS	denotes	members
T13756	32548-32553	VBN	denotes	found
T13757	32530-32532	IN	denotes	of
T13758	32533-32538	WDT	denotes	which
T13759	32539-32542	VBP	denotes	are
T13760	32543-32547	RB	denotes	also
T13761	32554-32556	IN	denotes	in
T13762	32557-32561	NN	denotes	TACC
T13763	32562-32572	VBG	denotes	containing
T13764	32584-32592	NNS	denotes	segments
T13765	32573-32583	JJ	denotes	paralogous
T13766	32593-32598	VBN	denotes	noted
T13767	32599-32601	IN	denotes	in
T13768	32602-32606	NNS	denotes	Figs
T13769	32610-32611	CD	denotes	3
T13770	32607-32608	CD	denotes	2
T13771	32608-32610	,	denotes	,
T13772	32612-32615	CC	denotes	and
T13773	32616-32626	JJ	denotes	Additional
T13774	32627-32631	NN	denotes	file
T13775	32632-32633	CD	denotes	1
T13776	32633-32634	.	denotes	.
T13777	32634-32688	sentence	denotes	(D): Predicted TACC interaction map based upon DTACC.
T13778	32635-32636	-LRB-	denotes	(
T13779	32636-32637	LS	denotes	D
T13780	32667-32670	NN	denotes	map
T13781	32637-32638	-RRB-	denotes	)
T13782	32638-32640	:	denotes	:
T13783	32640-32649	VBN	denotes	Predicted
T13784	32650-32654	NN	denotes	TACC
T13785	32655-32666	NN	denotes	interaction
T13786	32671-32676	VBN	denotes	based
T13787	32677-32681	IN	denotes	upon
T13788	32682-32687	NN	denotes	DTACC
T13789	32687-32688	.	denotes	.
T13790	32688-32742	sentence	denotes	(E): Vertebrate TACC interactions identified to date.
T13791	32689-32690	-LRB-	denotes	(
T13792	32690-32691	LS	denotes	E
T13793	32710-32722	NNS	denotes	interactions
T13794	32691-32692	-RRB-	denotes	)
T13795	32692-32694	:	denotes	:
T13796	32694-32704	NN	denotes	Vertebrate
T13797	32705-32709	NN	denotes	TACC
T13798	32723-32733	VBN	denotes	identified
T13799	32734-32736	IN	denotes	to
T13800	32737-32741	NN	denotes	date
T13801	32741-32742	.	denotes	.
T13802	32742-32820	sentence	denotes	? denotes uncertainty over the identity of a functional vertebrate homologue.
T13803	32743-32744	SYM	denotes	?
T13804	32745-32752	VBZ	denotes	denotes
T13805	32753-32764	NN	denotes	uncertainty
T13806	32765-32769	IN	denotes	over
T13807	32770-32773	DT	denotes	the
T13808	32774-32782	NN	denotes	identity
T13809	32783-32785	IN	denotes	of
T13810	32786-32787	DT	denotes	a
T13811	32810-32819	NN	denotes	homologue
T13812	32788-32798	JJ	denotes	functional
T13813	32799-32809	NN	denotes	vertebrate
T13818	32824-32825	NN	denotes	C
T13819	32825-32827	,	denotes	,
T13820	32827-32828	NN	denotes	D
T13821	32829-32832	CC	denotes	and
T13822	32833-32834	NN	denotes	E
T13823	32834-32836	,	denotes	,
T13824	32836-32837	``	denotes	'
T13825	32838-32839	''	denotes	'
T13826	32837-32838	SYM	denotes	*
T13827	32848-32851	CD	denotes	one
T13828	32860-32867	NNS	denotes	members
T13829	32852-32854	CC	denotes	or
T13830	32855-32859	JJR	denotes	more
T13831	32868-32870	IN	denotes	of
T13832	32871-32874	DT	denotes	the
T13833	32897-32903	NN	denotes	family
T13834	32875-32879	NN	denotes	TACC
T13835	32880-32882	CC	denotes	or
T13836	32883-32889	NN	denotes	Aurora
T13837	32890-32896	NN	denotes	kinase
T13838	32903-32904	.	denotes	.
T13918	38611-38615	NN	denotes	Lane
T13919	38616-38617	CD	denotes	3
T13920	38617-38619	SYM	denotes	:
T13921	38619-38620	CD	denotes	5
T13922	38620-38621	NN	denotes	%
T13923	38628-38630	IN	denotes	of
T13924	38631-38633	FW	denotes	in
T13925	38634-38639	FW	denotes	vitro
T13926	38657-38664	NN	denotes	protein
T13927	38640-38650	VBN	denotes	translated
T13928	38651-38654	NN	denotes	RXR
T13929	38655-38656	NN	denotes	β
T13930	38654-38655	HYPH	denotes	-
T13931	38664-38665	.	denotes	.
T13932	38665-38783	sentence	denotes	Bottom two panels represent Coomassie blue stained gels of pull down experiment showing loading of GST-TACC2 and GST.
T13933	38666-38672	JJ	denotes	Bottom
T13934	38677-38683	NNS	denotes	panels
T13935	38673-38676	CD	denotes	two
T13936	38684-38693	VBP	denotes	represent
T13937	38694-38703	NNP	denotes	Coomassie
T13938	38717-38721	NNS	denotes	gels
T13939	38704-38708	JJ	denotes	blue
T13940	38709-38716	VBN	denotes	stained
T13941	38722-38724	IN	denotes	of
T13942	38725-38729	VB	denotes	pull
T13943	38735-38745	NN	denotes	experiment
T13944	38730-38734	RP	denotes	down
T13945	38746-38753	VBG	denotes	showing
T13946	38754-38761	NN	denotes	loading
T13947	38762-38764	IN	denotes	of
T13948	38765-38768	NN	denotes	GST
T13949	38769-38774	NN	denotes	TACC2
T13950	38768-38769	HYPH	denotes	-
T13951	38775-38778	CC	denotes	and
T13952	38779-38782	NN	denotes	GST
T13953	38782-38783	.	denotes	.
T13889	38487-38489	IN	denotes	of
T13890	38490-38492	CD	denotes	12
T13891	38492-38493	NN	denotes	%
T13892	38494-38497	NN	denotes	SDS
T13893	38513-38516	NN	denotes	gel
T13894	38498-38512	NN	denotes	polyacrylamide
T13895	38517-38521	IN	denotes	with
T13896	38522-38524	FW	denotes	in
T13897	38525-38530	FW	denotes	vitro
T13898	38531-38541	VBN	denotes	translated
T13899	38548-38557	NN	denotes	construct
T13900	38542-38547	NN	denotes	RXRβ3
T13901	38558-38564	VBN	denotes	pulled
T13902	38565-38569	RP	denotes	down
T13903	38570-38574	IN	denotes	with
T13904	38575-38578	NN	denotes	GST
T13905	38579-38584	NN	denotes	TACC2
T13906	38578-38579	HYPH	denotes	-
T13907	38585-38586	-LRB-	denotes	(
T13908	38586-38590	NN	denotes	Lane
T13909	38591-38592	CD	denotes	1
T13910	38592-38593	-RRB-	denotes	)
T13911	38594-38596	CC	denotes	or
T13912	38597-38600	NN	denotes	GST
T13913	38601-38602	-LRB-	denotes	(
T13914	38602-38606	NN	denotes	Lane
T13915	38607-38608	CD	denotes	2
T13916	38608-38609	-RRB-	denotes	)
T13917	38609-38610	:	denotes	;
T193	143-153	sentence	denotes	Background
T1844	6782-6785	VBD	denotes	was
T1845	6797-6799	IN	denotes	in
T1846	6800-6803	DT	denotes	the
T1847	6804-6810	NN	denotes	genome
T1848	6811-6813	IN	denotes	of
T1849	6814-6817	DT	denotes	the
T4441	16867-16869	IN	denotes	of
T4442	16870-16874	NN	denotes	gene
T4443	16875-16880	NN	denotes	order
T4444	16881-16884	MD	denotes	can
T4445	16885-16889	RB	denotes	also
T4446	16949-16958	VBD	denotes	attempted
T4447	16898-16903	NNS	denotes	clues
T4448	16904-16906	IN	denotes	to
T4449	16907-16910	DT	denotes	the
T13875	38419-38421	FW	denotes	In
T13876	38422-38427	FW	denotes	vitro
T13877	38428-38439	NN	denotes	interaction
T13878	38440-38442	IN	denotes	of
T13879	38443-38448	NN	denotes	RXRβ3
T13880	38449-38452	CC	denotes	and
T13881	38453-38459	NNS	denotes	TACC2s
T13882	38459-38460	.	denotes	.
T13883	38460-38665	sentence	denotes	Top panel: Autoradiograph of 12% SDS polyacrylamide gel with in vitro translated RXRβ3 construct pulled down with GST-TACC2 (Lane 1) or GST (Lane 2); Lane 3: 5% input of in vitro translated RXR-β protein.
T13884	38461-38464	JJ	denotes	Top
T13885	38465-38470	NN	denotes	panel
T13886	38472-38486	NN	denotes	Autoradiograph
T13887	38470-38472	:	denotes	:
T13888	38622-38627	NN	denotes	input
T4450	16911-16920	NN	denotes	evolution
T4451	16921-16923	IN	denotes	of
T10439	42989-42996	NN	denotes	Cloning
T4452	16924-16928	NN	denotes	gene
T4453	16929-16939	NN	denotes	regulation
T4454	16939-16941	,	denotes	,
T4455	16941-16943	PRP	denotes	we
T4456	16944-16948	RB	denotes	next
T4457	16959-16961	TO	denotes	to
T4458	16962-16967	VB	denotes	trace
T4459	16968-16971	DT	denotes	the
T4460	16972-16981	NN	denotes	evolution
T4461	16982-16984	IN	denotes	of
T4462	16985-16990	DT	denotes	these
T4463	17002-17010	NNS	denotes	segments
T4464	16991-17001	JJ	denotes	paralogous
T7673	31264-31265	-LRB-	denotes	(
T7674	31265-31269	NN	denotes	Fig.
T7675	31270-31272	CD	denotes	6B
T7676	31272-31273	-RRB-	denotes	)
T7677	31273-31275	,	denotes	,
T7678	31275-31278	CC	denotes	and
T7679	31279-31283	RB	denotes	thus
T4465	17011-17013	IN	denotes	by
T7772	31795-33099	sentence	denotes	Figure 6 Functional evolution of the TACC proteins modeled in C. elegans and D. melanogaster. (A). C. elegans interaction map shows empirically defined interactions of ceTAC, and extrapolated interactions defined by [28]. (B): Using the BIND database [29], DTACC directly binds to TBPH and CG14540, and thus indirectly to chromatin remodeling complexes (SWI/SNF and histone acetyltransferases), DNA damage repair machinery (via RAD23), and RNA splicing, transport and translational machinery. (C): Predicted interaction map for vertebrate TACCs, based upon ceTAC, suggests an indirect interaction with the nuclear hormone receptor RXRβ. It is also of interest that this predicts a functional interaction with the LDB family, members of which are also found in TACC containing paralogous segments noted in Figs 2, 3 and Additional file 1. (D): Predicted TACC interaction map based upon DTACC. (E): Vertebrate TACC interactions identified to date. ? denotes uncertainty over the identity of a functional vertebrate homologue. In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family. Because of the evolutionary conservation of the TACC domain, we would predict that some of the functional interactions seen in C. elegans and D. melanogaster would be observed in higher animals.
T7773	32905-32912	IN	denotes	Because
T7774	32975-32982	VB	denotes	predict
T7775	32913-32915	IN	denotes	of
T7776	32916-32919	DT	denotes	the
T7777	32933-32945	NN	denotes	conservation
T7778	32920-32932	JJ	denotes	evolutionary
T7779	32946-32948	IN	denotes	of
T4466	17014-17023	VBG	denotes	examining
T4467	17024-17027	DT	denotes	the
T4468	17028-17034	NN	denotes	genome
T1710	5640-5649	NNP	denotes	Anopheles
T1711	5650-5657	NNP	denotes	gambiae
T1712	5658-5662	VBD	denotes	were
T1713	5663-5667	RB	denotes	also
T1812	6719-6720	NN	denotes	A
T1813	6720-6721	IN	denotes	t
T1814	6722-6725	JJ	denotes	the
T1815	6726-6727	sentence	denotes	b
T1816	6726-6727	VBN	denotes	b
T1817	6727-6741	sentence	denotes	ase of the cho
T1818	6727-6728	NN	denotes	a
T1819	6728-6729	VBZ	denotes	s
T1820	6729-6730	JJ	denotes	e
T1821	6731-6733	IN	denotes	of
T1822	6734-6735	VBG	denotes	t
T1823	6735-6737	JJ	denotes	he
T1824	6738-6739	VBN	denotes	c
T1825	6739-6740	JJ	denotes	h
T1826	6740-6741	NNS	denotes	o
T1827	6741-6747	sentence	denotes	rdate
T1828	6741-6742	NN	denotes	r
T1829	6742-6743	JJ	denotes	d
T1830	6743-6744	CC	denotes	a
T1831	6744-6746	NN	denotes	te
T1832	6747-6945	sentence	denotes	branch of life, a single TACC gene was identified in the genome of the urochordate Ciona intestinalis [11], and a partial TACC sequence from an analysis of the Halocynthia rortezi EST database [12].
T1833	6786-6796	VBN	denotes	identified
T1834	6747-6748	NN	denotes	b
T1835	6750-6753	NN	denotes	nch
T1836	6748-6750	NN	denotes	ra
T1837	6754-6756	IN	denotes	of
T1838	6757-6761	NN	denotes	life
T1839	6761-6763	,	denotes	,
T1840	6763-6764	DT	denotes	a
T1841	6777-6781	NN	denotes	gene
T1842	6765-6771	JJ	denotes	single
T1843	6772-6776	NN	denotes	TACC
T1850	6818-6829	NN	denotes	urochordate
T4469	17035-17037	IN	denotes	of
T4470	17038-17041	DT	denotes	the
T4471	17042-17050	NN	denotes	tunicate
T4401	15984-15992	NNS	denotes	clusters
T4402	15978-15983	CD	denotes	three
T4403	15993-15996	VBP	denotes	are
T4404	16005-16007	IN	denotes	on
T4405	16008-16017	JJ	denotes	different
T4406	16018-16029	NNS	denotes	chromosomes
T4407	16030-16032	IN	denotes	in
T4408	16033-16038	NN	denotes	mouse
T4409	16039-16042	CC	denotes	and
T4410	16043-16046	NN	denotes	rat
T4411	16047-16048	-LRB-	denotes	(
T4412	16048-16052	NN	denotes	Fig.
T4413	16053-16054	CD	denotes	2
T4414	16054-16055	-RRB-	denotes	)
T4415	16055-16057	,	denotes	,
T4416	16057-16064	RB	denotes	further
T4417	16065-16075	VBG	denotes	suggesting
T4418	16076-16080	IN	denotes	that
T4419	16107-16117	VBN	denotes	transposed
T4420	16081-16085	DT	denotes	this
T4421	16086-16093	NN	denotes	cluster
T4422	16094-16096	IN	denotes	of
T4423	16097-16102	NNS	denotes	genes
T4424	16103-16106	VBD	denotes	was
T4425	16118-16122	IN	denotes	into
T4426	16123-16127	DT	denotes	this
T4427	16128-16134	NN	denotes	region
T4428	16135-16140	IN	denotes	after
T4429	16141-16144	DT	denotes	the
T4430	16160-16170	NN	denotes	divergence
T4431	16145-16152	NN	denotes	primate
T4432	16153-16159	NN	denotes	rodent
T4433	16152-16153	HYPH	denotes	/
T4434	16170-16171	.	denotes	.
T4435	16171-16172	sentence	denotes
T4436	16842-17159	sentence	denotes	Because the conservation of gene order can also provide clues to the evolution of gene regulation, we next attempted to trace the evolution of these paralogous segments by examining the genome of the tunicate C. intestinalis [11] and the most "primitive" compact vertebrate genome sequenced to date, T. rubripes [14].
T4437	16842-16849	IN	denotes	Because
T4438	16890-16897	VB	denotes	provide
T4439	16850-16853	DT	denotes	the
T4440	16854-16866	NN	denotes	conservation
T4472	17051-17053	NNP	denotes	C.
T4473	17054-17066	NNP	denotes	intestinalis
T4474	17067-17068	-LRB-	denotes	[
T4475	17068-17070	CD	denotes	11
T4476	17070-17071	-RRB-	denotes	]
T4477	17072-17075	CC	denotes	and
T4478	17076-17079	DT	denotes	the
T4479	17116-17122	NN	denotes	genome
T4480	17080-17084	JJS	denotes	most
T4481	17086-17095	JJ	denotes	primitive
T5120	20581-20586	VB	denotes	await
T5121	20500-20502	,	denotes	,
T5122	20502-20505	DT	denotes	the
T5123	20512-20522	NN	denotes	resolution
T5124	20506-20511	JJ	denotes	final
T5125	20523-20525	IN	denotes	of
T5126	20526-20529	DT	denotes	the
T5127	20538-20547	NN	denotes	evolution
T5128	20530-20537	JJ	denotes	initial
T5129	20548-20550	IN	denotes	of
T5130	20551-20556	DT	denotes	these
T5131	20568-20575	NN	denotes	segment
T5132	20557-20567	JJ	denotes	paralogous
T5133	20576-20580	MD	denotes	will
T5134	20587-20590	DT	denotes	the
T5135	20591-20601	NN	denotes	sequencing
T5136	20602-20604	IN	denotes	of
T5137	20605-20608	DT	denotes	the
T5138	20631-20638	NNS	denotes	genomes
T5139	20609-20618	NN	denotes	amphioxus
T5140	20619-20622	CC	denotes	and
T5141	20623-20630	NN	denotes	lamprey
T5142	20638-20640	,	denotes	,
T5143	20640-20645	WDT	denotes	which
T5144	20651-20655	VBP	denotes	have
T5145	20646-20650	RB	denotes	only
T5146	20656-20659	CD	denotes	one
T5147	20665-20669	NN	denotes	gene
T5148	20660-20664	NN	denotes	FGFR
T5149	20669-20671	,	denotes	,
T5150	20671-20674	CC	denotes	and
T5151	20675-20684	RB	denotes	therefore
T5152	20697-20704	VB	denotes	contain
T5153	20685-20691	MD	denotes	should
T5154	20692-20696	RB	denotes	only
T5155	20705-20708	CD	denotes	one
T5156	20709-20713	NN	denotes	copy
T5157	20714-20716	IN	denotes	of
T5158	20717-20720	DT	denotes	the
T5159	20741-20746	NNS	denotes	genes
T5160	20721-20726	JJ	denotes	other
R8	T182	T180	amod	acidic,genes
R9	T183	T184	amod	coiled,coil
R6202	T9719	T9715	prep	to,response
R6203	T9720	T9719	pobj	hypoxia,to
R6204	T9721	T9720	cc	and,hypoxia
R6205	T9722	T9723	amod	polyaromatic,hydrocarbons
R6206	T9723	T9720	conj	hydrocarbons,hypoxia
R6207	T9724	T9725	punct	[,7
R6208	T9725	T9694	parataxis	7,was
R6209	T9726	T9725	punct	],7
R6210	T9727	T9694	punct	.,was
R6211	T9729	T9730	compound	Mouse,TACC3
R6212	T9730	T9731	nsubjpass	TACC3,reported
R6213	T9732	T9731	aux	has,reported
R6214	T9733	T9731	advmod	also,reported
R6215	T9734	T9731	auxpass	been,reported
R6216	T9735	T9736	aux	to,interact
R6217	T9736	T9731	xcomp	interact,reported
R6218	T9737	T9736	prep	with,interact
R6219	T9738	T9739	det	the,STAT5
R6220	T9739	T9737	pobj	STAT5,with
R6221	T9740	T9739	compound	transcription,STAT5
R6222	T9741	T9739	compound	factor,STAT5
R6223	T9742	T9743	punct	[,33
R6224	T9743	T9731	parataxis	33,reported
R6225	T9744	T9743	punct	],33
R6226	T9745	T9731	punct	.,reported
R6227	T9747	T9748	advmod	Recently,demonstrated
R6228	T9749	T9748	punct	", ",demonstrated
R6229	T9750	T9748	nsubj	we,demonstrated
R6230	T9751	T9748	aux	have,demonstrated
R6231	T9752	T9753	mark	that,bind
R6232	T9753	T9748	ccomp	bind,demonstrated
R6233	T9754	T9753	nsubj	TACC2,bind
R6234	T9755	T9754	cc	and,TACC2
R6235	T9756	T9754	conj	TACC3,TACC2
R6236	T9757	T9753	aux	can,bind
R6237	T9758	T9753	prep	to,bind
R6238	T9759	T9760	amod	nuclear,acetyltransferases
R6239	T9760	T9758	pobj	acetyltransferases,to
R6240	T9761	T9760	compound	histone,acetyltransferases
R6241	T9762	T9763	punct	[,34
R6242	T9763	T9748	parataxis	34,demonstrated
R6243	T9764	T9763	punct	],34
R6244	T9765	T9748	punct	", ",demonstrated
R6245	T9766	T9767	advmod	further,confirming
R6246	T9767	T9748	advcl	confirming,demonstrated
R6247	T9768	T9769	det	a,role
R6248	T9769	T9767	dobj	role,confirming
R6249	T9770	T9771	advmod	more,direct
R6250	T9771	T9769	amod	direct,role
R6251	T9772	T9769	prep	for,role
R6252	T9773	T9774	det	the,proteins
R6253	T9774	T9772	pobj	proteins,for
R6254	T9775	T9774	compound	TACC,proteins
R6255	T9776	T9769	prep	in,role
R6256	T9777	T9778	amod	transcriptional,events
R6257	T9778	T9776	pobj	events,in
R6258	T9779	T9777	cc	and,transcriptional
R6259	T9780	T9781	compound	chromatin,remodeling
R6260	T9781	T9777	conj	remodeling,transcriptional
R6261	T9782	T9748	punct	.,demonstrated
R6262	T9784	T9785	advmod	Interestingly,interact
R6263	T9786	T9787	mark	although,interact
R6264	T9787	T9785	advcl	interact,interact
R6265	T9788	T9789	det	all,proteins
R6266	T9789	T9787	nsubj	proteins,interact
R6267	T9790	T9789	amod	human,proteins
R6268	T9791	T9789	compound	TACC,proteins
R6269	T9792	T9787	aux	can,interact
R6270	T9793	T9787	advmod	directly,interact
R6271	T9794	T9787	prep	with,interact
R6272	T9795	T9796	det	the,acetyltransferase
R6273	T9796	T9794	pobj	acetyltransferase,with
R6274	T9797	T9796	compound	histone,acetyltransferase
R6275	T9798	T9796	appos	pCAF,acetyltransferase
R6276	T9799	T9800	advmod	in,vitro
R6277	T9800	T9787	advmod	vitro,interact
R6278	T9801	T9785	punct	", ",interact
R6279	T9802	T9803	det	the,isoforms
R6280	T9803	T9785	nsubj	isoforms,interact
R6281	T9804	T9803	compound	TACC1,isoforms
R6282	T9805	T9803	acl	expressed,isoforms
R6283	T9806	T9805	prep	in,expressed
R6284	T9807	T9808	amod	human,cells
R6285	T9808	T9806	pobj	cells,in
R6286	T9809	T9810	compound	breast,cancer
R6287	T9810	T9808	compound	cancer,cells
R6288	T9811	T9785	aux	do,interact
R6289	T9812	T9785	neg	not,interact
R6290	T9813	T9785	prep	with,interact
R6291	T9814	T9815	det	this,acetylase
R6292	T9815	T9813	pobj	acetylase,with
R6293	T9816	T9815	compound	histone,acetylase
R6294	T9817	T9818	punct	[,34
R6295	T9818	T9785	parataxis	34,interact
R6296	T9819	T9818	punct	],34
R6297	T9820	T9785	punct	.,interact
R6298	T9822	T9823	nsubj	This,be
R6299	T9824	T9823	aux	may,be
R6300	T9825	T9823	acomp	attributable,be
R6301	T9826	T9825	prep	to,attributable
R6302	T9827	T9828	det	the,function
R6303	T9828	T9826	pobj	function,to
R6304	T9829	T9828	amod	proposed,function
R6305	T9830	T9828	prep	of,function
R6306	T9831	T9832	det	the,variants
R6307	T9832	T9830	pobj	variants,of
R6308	T9833	T9834	npadvmod	Exon,containing
R6309	T9834	T9832	amod	containing,variants
R6310	T9835	T9833	nummod	1,Exon
R6311	T9836	T9832	compound	TACC1,variants
R6312	T9837	T9832	prep	in,variants
R6313	T9838	T9839	compound	RNA,processing
R6314	T9839	T9837	pobj	processing,in
R6315	T9840	T9823	punct	", ",be
R6316	T9841	T9823	prep	via,be
R6317	T9842	T9843	det	the,interaction
R6318	T9843	T9841	pobj	interaction,via
R6319	T9844	T9843	prep	with,interaction
R6320	T9845	T9844	pobj	LSm,with
R6321	T9846	T9845	punct	-,LSm
R6322	T9847	T9845	nummod	7,LSm
R6323	T9848	T9845	cc	and,LSm
R6324	T9849	T9845	conj	SmG,LSm
R6325	T9850	T9851	punct	[,19
R6326	T9851	T9823	parataxis	19,be
R6327	T9852	T9851	punct	],19
R6328	T9853	T9823	punct	.,be
R6329	T9855	T9856	advmod	Thus,adds
R6330	T9857	T9856	punct	", ",adds
R6331	T9858	T9859	amod	alternative,splicing
R6332	T9859	T9856	nsubj	splicing,adds
R6333	T9860	T9859	prep	of,splicing
R6334	T9861	T9862	det	the,gene
R6335	T9862	T9860	pobj	gene,of
R6336	T9863	T9862	compound	TACC1,gene
R6337	T9864	T9865	amod	further,diversity
R6338	T9865	T9856	dobj	diversity,adds
R6339	T9866	T9856	prep	to,adds
R6340	T9867	T9868	compound	TACC1,function
R6341	T9868	T9866	pobj	function,to
R6342	T9869	T9856	punct	", ",adds
R6343	T9870	T9871	mark	as,change
R6344	T9871	T9856	advcl	change,adds
R6345	T9872	T9873	det	the,deletion
R6346	T9873	T9871	nsubj	deletion,change
R6347	T9874	T9873	prep	of,deletion
R6348	T9875	T9876	amod	specific,exons
R6349	T9876	T9874	pobj	exons,of
R6350	T9877	T9876	cc	and,exons
R6351	T9878	T9879	poss	their,domains
R6352	T9879	T9876	conj	domains,exons
R6353	T9880	T9879	amod	associated,domains
R6354	T9881	T9879	compound	binding,domains
R6355	T9882	T9871	aux	will,change
R6356	T9883	T9884	det	the,complexes
R6357	T9884	T9871	dobj	complexes,change
R6358	T9885	T9884	amod	potential,complexes
R6359	T9886	T9884	compound	protein,complexes
R6360	T9887	T9888	prep	with,associate
R6361	T9888	T9884	relcl	associate,complexes
R6362	T9889	T9887	pobj	which,with
R6363	T9890	T9888	nsubj	they,associate
R6364	T9891	T9888	aux	can,associate
R6365	T9892	T9871	punct	", ",change
R6366	T9893	T9894	preconj	either,by
R6367	T9894	T9871	prep	by,change
R6368	T9895	T9894	advmod	directly,by
R6369	T9896	T9894	punct	", ",by
R6370	T9897	T9894	cc	or,by
R6371	T9898	T9894	pcomp	redirecting,by
R6372	T9899	T9900	det	the,variants
R6373	T9900	T9898	dobj	variants,redirecting
R6374	T9901	T9900	compound	splice,variants
R6375	T9902	T9898	prep	to,redirecting
R6376	T9903	T9904	amod	different,compartments
R6377	T9904	T9902	pobj	compartments,to
R6378	T9905	T9904	amod	subcellular,compartments
R6379	T9906	T9856	punct	.,adds
R6380	T9908	T9909	prep	With,is
R6381	T9910	T9911	det	the,duplication
R6382	T9911	T9908	pobj	duplication,With
R6383	T9912	T9911	prep	of,duplication
R6384	T9913	T9914	det	the,ancestor
R6385	T9914	T9912	pobj	ancestor,of
R6386	T9915	T9916	compound	TACC1,TACC2
R6387	T9916	T9914	compound	TACC2,ancestor
R6388	T9917	T9916	punct	/,TACC2
R6389	T9918	T9909	punct	", ",is
R6390	T9919	T9909	nsubj	it,is
R6391	T9920	T9909	acomp	apparent,is
R6392	T9921	T9922	mark	that,introduced
R6393	T9922	T9909	ccomp	introduced,is
R6394	T9923	T9924	det	an,diversity
R6395	T9924	T9922	nsubjpass	diversity,introduced
R6396	T9925	T9926	advmod	even,greater
R6397	T9926	T9924	amod	greater,diversity
R6398	T9927	T9924	amod	functional,diversity
R6399	T9928	T9922	aux	may,introduced
R6400	T9929	T9922	aux	have,introduced
R6401	T9930	T9922	auxpass	been,introduced
R6402	T9931	T9922	prep	into,introduced
R6403	T9932	T9933	det	the,family
R6404	T9933	T9931	pobj	family,into
R6405	T9934	T9933	compound	TACC,family
R6406	T9935	T9909	punct	.,is
R6407	T9937	T9938	det	The,protein
R6408	T9938	T9940	nsubj	protein,retains
R6409	T9939	T9938	compound	TACC2,protein
R6410	T9941	T9942	det	the,ability
R6411	T9942	T9940	dobj	ability,retains
R6412	T9943	T9942	prep	of,ability
R6413	T9944	T9943	pobj	TACC3,of
R6414	T9945	T9946	aux	to,interact
R6415	T9946	T9942	acl	interact,ability
R6416	T9947	T9946	prep	with,interact
R6417	T9948	T9947	pobj	GAS41,with
R6418	T9949	T9948	punct	", ",GAS41
R6419	T9950	T9948	conj	INI1,GAS41
R6420	T9951	T9950	punct	", ",INI1
R6421	T9952	T9953	compound	histone,acetyltransferases
R6422	T9953	T9950	conj	acetyltransferases,INI1
R6423	T9954	T9953	cc	and,acetyltransferases
R6424	T9955	T9956	compound	transcription,factors
R6425	T9956	T9953	conj	factors,acetyltransferases
R6426	T9957	T9956	punct	(,factors
R6427	T9958	T9959	prep	in,RXRβ
R6428	T9959	T9956	appos	RXRβ,factors
R6429	T9960	T9961	det	this,case
R6430	T9961	T9958	pobj	case,in
R6431	T9962	T9959	punct	", ",RXRβ
R6432	T9963	T9956	punct	),factors
R6433	T9964	T9965	punct	(,Fig.
R6434	T9965	T9946	parataxis	Fig.,interact
R6435	T9966	T9965	nummod	7,Fig.
R6436	T9967	T9965	punct	),Fig.
R6437	T9968	T9969	punct	[,34
R6438	T9969	T9946	parataxis	34,interact
R6439	T9970	T9969	nummod	3,34
R6440	T9971	T9969	punct	",",34
R6441	T9972	T9969	punct	],34
R6442	T9973	T9940	punct	.,retains
R6443	T9975	T9976	advmod	However,indicates
R6444	T9977	T9976	punct	", ",indicates
R6445	T9978	T9979	det	the,splicing
R6446	T9979	T9976	nsubj	splicing,indicates
R6447	T9980	T9981	npadvmod	tissue,specific
R6448	T9981	T9979	amod	specific,splicing
R6449	T9982	T9979	prep	of,splicing
R6450	T9983	T9984	det	the,exon
R6451	T9984	T9982	pobj	exon,of
R6452	T9985	T9986	nummod	5,kb
R6453	T9986	T9984	compound	kb,exon
R6454	T9987	T9984	prep	in,exon
R6455	T9988	T9989	det	the,isoform
R6456	T9989	T9987	pobj	isoform,in
R6457	T9990	T9989	compound	TACC2l,isoform
R6458	T9991	T9992	punct	[,3
R6459	T9992	T9979	parataxis	3,splicing
R6460	T9993	T9992	punct	],3
R6461	T9994	T9995	mark	that,has
R6462	T9995	T9976	ccomp	has,indicates
R6463	T9996	T9997	det	this,protein
R6464	T9997	T9995	nsubj	protein,has
R6465	T9998	T9999	amod	several,functions
R6466	T9999	T9995	dobj	functions,has
R6467	T10000	T9999	amod	temporal,functions
R6468	T10001	T10000	cc	and,temporal
R6469	T10002	T10003	npadvmod	tissue,specific
R6470	T10003	T10000	conj	specific,temporal
R6471	T10004	T10005	advmod	yet,identified
R6472	T10005	T9999	advcl	identified,functions
R6473	T10006	T10005	aux	to,identified
R6474	T10007	T10005	auxpass	be,identified
R6475	T10008	T9976	punct	.,indicates
R6478	T10099	T10098	cc	and,Compilation
R6479	T10100	T10098	conj	assembly,Compilation
R6480	T10101	T10098	prep	of,Compilation
R6481	T10102	T10103	advmod	previously,uncharacterized
R6482	T10103	T10104	amod	uncharacterized,cDNAs
R6483	T10104	T10101	pobj	cDNAs,of
R6484	T10105	T10104	compound	TACC,cDNAs
R6485	T10106	T10104	cc	and,cDNAs
R6486	T10107	T10104	conj	genes,cDNAs
R6487	T10109	T10110	amod	Corresponding,sequences
R6488	T10110	T10112	nsubjpass	sequences,identified
R6489	T10111	T10110	amod	orthologous,sequences
R6490	T10113	T10110	prep	for,sequences
R6491	T10114	T10115	nmod	TACC,families
R6492	T10115	T10113	pobj	families,for
R6493	T10116	T10114	punct	", ",TACC
R6494	T10117	T10114	conj	RHAMM,TACC
R6495	T10118	T10117	punct	", ",RHAMM
R6496	T10119	T10117	conj	KLP,RHAMM
R6497	T10120	T10119	punct	", ",KLP
R6498	T10121	T10119	conj	KIF,KLP
R6499	T10122	T10121	punct	", ",KIF
R6500	T10123	T10121	conj	TPM,KIF
R6501	T10124	T10123	cc	and,TPM
R6502	T10125	T10123	conj	keratins,TPM
R6503	T10126	T10112	auxpass	were,identified
R6504	T10127	T10112	advmod	initially,identified
R6505	T10128	T10112	advcl	using,identified
R6506	T10129	T10130	det	the,program
R6507	T10130	T10128	dobj	program,using
R6508	T10131	T10130	compound	TBLASTN,program
R6509	T10132	T10133	punct	[,36
R6510	T10133	T10128	parataxis	36,using
R6511	T10134	T10133	punct	],36
R6512	T10135	T10136	aux	to,search
R6513	T10136	T10128	advcl	search,using
R6514	T10137	T10138	det	the,databases
R6515	T10138	T10136	dobj	databases,search
R6516	T10139	T10138	amod	published,databases
R6517	T10140	T10138	amod	genomic,databases
R6518	T10141	T10140	cc	and,genomic
R6519	T10142	T10140	conj	cDNA,genomic
R6520	T10143	T10112	punct	.,identified
R6521	T10145	T10146	prep	For,produced
R6522	T10147	T10148	compound	Takifugu,rubripes
R6523	T10148	T10145	pobj	rubripes,For
R6524	T10149	T10146	punct	", ",produced
R6525	T10150	T10151	compound	gene,predictions
R6526	T10151	T10146	nsubjpass	predictions,produced
R6527	T10152	T10146	auxpass	were,produced
R6528	T10153	T10146	agent	by,produced
R6529	T10154	T10155	det	the,pipeline
R6530	T10155	T10153	pobj	pipeline,by
R6531	T10156	T10155	nmod	Ensembl,pipeline
R6532	T10157	T10155	amod	automated,pipeline
R6533	T10158	T10159	punct	[,37
R6534	T10159	T10155	parataxis	37,pipeline
R6535	T10160	T10159	punct	],37
R6536	T10161	T10155	cc	and,pipeline
R6537	T10162	T10163	det	the,server
R6538	T10163	T10155	conj	server,pipeline
R6539	T10164	T10163	compound	JGI,server
R6540	T10165	T10163	compound	blast,server
R6541	T10166	T10146	punct	.,produced
R6542	T10168	T10169	compound	DNA,sequences
R6543	T10169	T10170	nsubj	sequences,extracted
R6544	T10171	T10169	acl	covering,sequences
R6545	T10172	T10173	det	the,regions
R6546	T10173	T10171	dobj	regions,covering
R6547	T10174	T10173	compound	homology,regions
R6548	T10175	T10170	aux	were,extracted
R6549	T10176	T10170	cc	and,extracted
R6550	T10177	T10170	conj	analyzed,extracted
R6551	T10178	T10177	prep	by,analyzed
R6552	T10179	T10178	pobj	Genscan,by
R6553	T10180	T10181	aux	to,obtain
R6554	T10181	T10170	advcl	obtain,extracted
R6555	T10182	T10183	amod	potential,exons
R6556	T10183	T10181	dobj	exons,obtain
R6557	T10184	T10170	punct	.,extracted
R6558	T10186	T10187	prep	In,added
R6559	T10188	T10189	det	some,cases
R6560	T10189	T10186	pobj	cases,In
R6561	T10190	T10187	punct	", ",added
R6562	T10191	T10187	nsubjpass	exons,added
R6563	T10192	T10187	auxpass	were,added
R6564	T10193	T10187	cc	or,added
R6565	T10194	T10187	conj	modified,added
R6566	T10195	T10194	prep	based,modified
R6567	T10196	T10195	prep	on,based
R6568	T10197	T10198	det	the,similarity
R6569	T10198	T10196	pobj	similarity,on
R6570	T10199	T10198	amod	best,similarity
R6571	T10200	T10198	prep	of,similarity
R6572	T10201	T10202	amod	translated,peptides
R6573	T10202	T10200	pobj	peptides,of
R6574	T10203	T10198	prep	to,similarity
R6575	T10204	T10205	det	the,proteins
R6576	T10205	T10203	pobj	proteins,to
R6577	T10206	T10205	amod	corresponding,proteins
R6578	T10207	T10205	nmod	mouse,proteins
R6579	T10208	T10207	cc	and,mouse
R6580	T10209	T10207	conj	human,mouse
R6581	T10210	T10187	punct	.,added
R6582	T10212	T10213	prep	For,used
R6583	T10214	T10212	pobj	regions,For
R6584	T10215	T10214	prep	with,regions
R6585	T10216	T10217	amod	low,similarity
R6586	T10217	T10215	pobj	similarity,with
R6587	T10218	T10217	compound	sequence,similarity
R6588	T10219	T10213	punct	", ",used
R6589	T10220	T10221	amod	genomic,sequences
R6590	T10221	T10213	nsubjpass	sequences,used
R6591	T10222	T10221	prep	from,sequences
R6592	T10223	T10224	det	the,pufferfish
R6593	T10224	T10222	pobj	pufferfish,from
R6594	T10225	T10226	amod	fresh,water
R6595	T10226	T10224	compound	water,pufferfish
R6596	T10227	T10224	punct	", ",pufferfish
R6597	T10228	T10229	compound	Tetraodon,nigroviridis
R6598	T10229	T10224	appos	nigroviridis,pufferfish
R6599	T10230	T10213	auxpass	were,used
R6600	T10231	T10213	prep	as,used
R6601	T10232	T10233	amod	additional,means
R6602	T10233	T10231	pobj	means,as
R6603	T10234	T10235	aux	to,verify
R6604	T10235	T10233	advcl	verify,means
R6605	T10236	T10237	det	the,exons
R6606	T10237	T10235	dobj	exons,verify
R6607	T10238	T10237	amod	predicted,exons
R6608	T10239	T10213	punct	.,used
R6609	T10241	T10242	prep	Due,obtained
R6610	T10243	T10241	pcomp	to,Due
R6611	T10244	T10245	det	the,variability
R6612	T10245	T10241	pobj	variability,Due
R6613	T10246	T10245	prep	of,variability
R6614	T10247	T10248	det	the,region
R6615	T10248	T10246	pobj	region,of
R6616	T10249	T10248	amod	central,region
R6617	T10250	T10248	prep	of,region
R6618	T10251	T10252	compound	vertebrate,cDNAs
R6619	T10252	T10250	pobj	cDNAs,of
R6620	T10253	T10252	compound	TACC3,cDNAs
R6621	T10254	T10255	punct	(,see
R6622	T10255	T10245	parataxis	see,variability
R6623	T10256	T10255	dobj	text,see
R6624	T10257	T10255	punct	),see
R6625	T10258	T10242	punct	", ",obtained
R6626	T10259	T10260	aux	to,confirm
R6627	T10260	T10242	advcl	confirm,obtained
R6628	T10261	T10260	advmod	further,confirm
R6629	T10262	T10260	dobj	prediction,confirm
R6630	T10263	T10262	prep	of,prediction
R6631	T10264	T10265	det	the,rubripes
R6632	T10265	T10263	pobj	rubripes,of
R6633	T10266	T10265	compound	Takifugu,rubripes
R6634	T10267	T10265	appos	TACC3,rubripes
R6635	T10268	T10242	punct	", ",obtained
R6636	T10269	T10270	amod	full,length
R6637	T10270	T10271	compound	length,cDNAs
R6638	T10271	T10242	nsubjpass	cDNAs,obtained
R6639	T10272	T10271	acl	corresponding,cDNAs
R6640	T10273	T10272	prep	to,corresponding
R6641	T10274	T10275	det	the,TACC3
R6642	T10275	T10273	pobj	TACC3,to
R6643	T10276	T10275	compound	Danio,TACC3
R6644	T10277	T10275	compound	rerio,TACC3
R6645	T10278	T10279	punct	(,2639991
R6646	T10279	T10275	parataxis	2639991,TACC3
R6647	T10280	T10279	nmod	IMAGE,2639991
R6648	T10281	T10279	nmod	clones,2639991
R6649	T10282	T10279	punct	", ",2639991
R6650	T10283	T10279	conj	2640369,2639991
R6651	T10284	T10283	cc	and,2640369
R6652	T10285	T10283	conj	3724452,2640369
R6653	T10286	T10279	punct	),2639991
R6654	T10287	T10242	auxpass	were,obtained
R6655	T10288	T10242	advmod	also,obtained
R6656	T10289	T10242	prep	from,obtained
R6657	T10290	T10289	pobj	A.T.C.C.,from
R6658	T10291	T10242	cc	and,obtained
R6659	T10292	T10293	advmod	fully,sequenced
R6660	T10293	T10242	conj	sequenced,obtained
R6661	T10294	T10242	punct	.,obtained
R6662	T10296	T10297	amod	Potential,segments
R6663	T10297	T10300	nsubjpass	segments,identified
R6664	T10298	T10297	amod	paralogous,segments
R6665	T10299	T10297	amod	chromosomal,segments
R6666	T10301	T10297	cc	and,segments
R6667	T10302	T10297	conj	scaffold,segments
R6668	T10303	T10300	auxpass	were,identified
R6669	T10304	T10300	prep	by,identified
R6670	T10305	T10304	pcomp	searching,by
R6671	T10306	T10307	det	the,databases
R6672	T10307	T10305	dobj	databases,searching
R6673	T10308	T10307	amod	public,databases
R6674	T10309	T10307	acl	deposited,databases
R6675	T10310	T10309	prep	at,deposited
R6676	T10311	T10310	pobj	NCBI,at
R6677	T10312	T10310	cc	and,at
R6678	T10313	T10310	conj	at,at
R6679	T10314	T10315	det	the,Project
R6680	T10315	T10313	pobj	Project,at
R6681	T10316	T10317	compound	Human,Genome
R6682	T10317	T10315	compound	Genome,Project
R6683	T10318	T10315	compound	Mapping,Project
R6684	T10319	T10315	punct	", ",Project
R6685	T10320	T10315	npadvmod	Cambridge,Project
R6686	T10321	T10320	npadvmod	UK,Cambridge
R6687	T10322	T10300	punct	.,identified
R6688	T10440	T10439	prep	of,Cloning
R6689	T10441	T10442	compound	vertebrate,TACC
R6690	T10442	T10443	compound	TACC,cDNAs
R6691	T10443	T10440	pobj	cDNAs,of
R6692	T10445	T10446	det	The,TACC3
R6693	T10446	T10448	nsubjpass	TACC3,cloned
R6694	T10447	T10446	compound	rabbit,TACC3
R6695	T10449	T10448	auxpass	was,cloned
R6696	T10450	T10448	prep	by,cloned
R6697	T10451	T10452	compound	rt,PCR
R6698	T10452	T10450	pobj	PCR,by
R6699	T10453	T10452	punct	-,PCR
R6700	T10454	T10448	advcl	using,cloned
R6701	T10455	T10456	det	the,primer
R6702	T10456	T10454	dobj	primer,using
R6703	T10457	T10458	punct	"""",specific
R6704	T10458	T10456	amod	specific,primer
R6705	T10459	T10458	npadvmod	TACC4,specific
R6706	T10460	T10458	punct	"""",specific
R6707	T10461	T10456	appos	T4RACE2,primer
R6708	T10462	T10463	punct	[,9
R6709	T10463	T10456	parataxis	9,primer
R6710	T10464	T10463	punct	],9
R6711	T10465	T10466	punct	(,cccgaactgctccaggtaatcgatctc
R6712	T10466	T10456	parataxis	cccgaactgctccaggtaatcgatctc,primer
R6713	T10467	T10466	nummod	5,cccgaactgctccaggtaatcgatctc
R6714	T10468	T10467	punct	',5
R6715	T10469	T10466	punct	-,cccgaactgctccaggtaatcgatctc
R6716	T10470	T10466	punct	-,cccgaactgctccaggtaatcgatctc
R6717	T10471	T10466	nummod	3,cccgaactgctccaggtaatcgatctc
R6718	T10472	T10466	punct	',cccgaactgctccaggtaatcgatctc
R6719	T10473	T10466	punct	),cccgaactgctccaggtaatcgatctc
R6720	T10474	T10456	cc	and,primer
R6721	T10475	T10476	det	a,primer
R6722	T10476	T10456	conj	primer,primer
R6723	T10477	T10476	compound	consensus,primer
R6724	T10478	T10476	punct	", ",primer
R6725	T10479	T10476	appos	T3con2,primer
R6726	T10480	T10476	punct	", ",primer
R6727	T10481	T10476	acl	designed,primer
R6728	T10482	T10481	prep	to,designed
R6729	T10483	T10484	det	the,region
R6730	T10484	T10482	pobj	region,to
R6731	T10485	T10484	acl	encompassing,region
R6732	T10486	T10487	det	the,initiator
R6733	T10487	T10485	dobj	initiator,encompassing
R6734	T10488	T10487	compound	vertebrate,initiator
R6735	T10489	T10487	compound	TACC3,initiator
R6736	T10490	T10487	appos	methionine,initiator
R6737	T10491	T10492	punct	(,tatgagtctgcaggtcttaaacgac
R6738	T10492	T10487	parataxis	tatgagtctgcaggtcttaaacgac,initiator
R6739	T10493	T10492	nummod	5,tatgagtctgcaggtcttaaacgac
R6740	T10494	T10493	punct	',5
R6741	T10495	T10492	punct	-,tatgagtctgcaggtcttaaacgac
R6742	T10496	T10492	punct	-,tatgagtctgcaggtcttaaacgac
R6743	T10497	T10492	nummod	3,tatgagtctgcaggtcttaaacgac
R6744	T10498	T10492	punct	',tatgagtctgcaggtcttaaacgac
R6745	T10499	T10492	punct	),tatgagtctgcaggtcttaaacgac
R6746	T10500	T10448	punct	.,cloned
R6747	T10502	T10503	prep	For,based
R6748	T10504	T10502	pcomp	cloning,For
R6749	T10505	T10506	det	the,cDNA
R6750	T10506	T10504	dobj	cDNA,cloning
R6751	T10507	T10508	compound	mouse,Tacc1X
R6752	T10508	T10506	compound	Tacc1X,cDNA
R6753	T10509	T10503	punct	", ",based
R6754	T10510	T10511	det	the,primers
R6755	T10511	T10503	nsubjpass	primers,based
R6756	T10512	T10511	acl	used,primers
R6757	T10513	T10503	auxpass	were,based
R6758	T10514	T10503	prep	upon,based
R6759	T10515	T10516	det	the,sequence
R6760	T10516	T10514	pobj	sequence,upon
R6761	T10517	T10516	amod	genomic,sequence
R6762	T10518	T10516	acl	reported,sequence
R6763	T10519	T10516	punct	", ",sequence
R6764	T10520	T10516	cc	and,sequence
R6765	T10521	T10522	det	the,sequence
R6766	T10522	T10516	conj	sequence,sequence
R6767	T10523	T10522	prep	of,sequence
R6768	T10524	T10525	det	the,clone
R6769	T10525	T10523	pobj	clone,of
R6770	T10526	T10525	compound	IMAGE,clone
R6771	T10527	T10525	compound	cDNA,clone
R6772	T10528	T10525	appos	4933429K08,clone
R6773	T10529	T10522	punct	: ,sequence
R6774	T10530	T10522	appos	T1XF,sequence
R6775	T10531	T10532	punct	(,ccatgttcagtcattggcaggtc
R6776	T10532	T10530	parataxis	ccatgttcagtcattggcaggtc,T1XF
R6777	T10533	T10532	nummod	5,ccatgttcagtcattggcaggtc
R6778	T10534	T10533	punct	',5
R6779	T10535	T10532	punct	-,ccatgttcagtcattggcaggtc
R6780	T10536	T10532	punct	-,ccatgttcagtcattggcaggtc
R6781	T10537	T10532	nummod	3,ccatgttcagtcattggcaggtc
R6782	T10538	T10532	punct	',ccatgttcagtcattggcaggtc
R6783	T10539	T10532	punct	),ccatgttcagtcattggcaggtc
R6784	T10540	T10530	punct	", ",T1XF
R6785	T10541	T10530	conj	T1XF2,T1XF
R6786	T10542	T10543	punct	(,ctgcagaaccaacagttcaag
R6787	T10543	T10541	parataxis	ctgcagaaccaacagttcaag,T1XF2
R6788	T10544	T10543	nummod	5,ctgcagaaccaacagttcaag
R6789	T10545	T10544	punct	',5
R6790	T10546	T10543	punct	-,ctgcagaaccaacagttcaag
R6791	T10547	T10543	punct	-,ctgcagaaccaacagttcaag
R6792	T10548	T10543	nummod	3,ctgcagaaccaacagttcaag
R6793	T10549	T10543	punct	',ctgcagaaccaacagttcaag
R6794	T10550	T10543	punct	),ctgcagaaccaacagttcaag
R6795	T10551	T10541	punct	", ",T1XF2
R6796	T10552	T10541	conj	T1XR1,T1XF2
R6797	T10553	T10554	punct	(,agatctgtgacatcacagctc
R6798	T10554	T10552	parataxis	agatctgtgacatcacagctc,T1XR1
R6799	T10555	T10554	nummod	5,agatctgtgacatcacagctc
R6800	T10556	T10555	punct	',5
R6801	T10557	T10554	punct	-,agatctgtgacatcacagctc
R6802	T10558	T10554	punct	-,agatctgtgacatcacagctc
R6803	T10559	T10554	nummod	3,agatctgtgacatcacagctc
R6804	T10560	T10554	punct	',agatctgtgacatcacagctc
R6805	T10561	T10554	punct	),agatctgtgacatcacagctc
R6806	T10562	T10552	punct	", ",T1XR1
R6807	T10563	T10552	conj	T1XR2,T1XR1
R6808	T10564	T10565	punct	(,ctcgagtcagttagtcttatccagctt
R6809	T10565	T10563	parataxis	ctcgagtcagttagtcttatccagctt,T1XR2
R6810	T10566	T10565	nummod	5,ctcgagtcagttagtcttatccagctt
R6811	T10567	T10566	punct	',5
R6812	T10568	T10565	punct	-,ctcgagtcagttagtcttatccagctt
R6813	T10569	T10565	punct	-,ctcgagtcagttagtcttatccagctt
R6814	T10570	T10565	nummod	3,ctcgagtcagttagtcttatccagctt
R6815	T10571	T10565	punct	',ctcgagtcagttagtcttatccagctt
R6816	T10572	T10565	punct	),ctcgagtcagttagtcttatccagctt
R6817	T10573	T10563	punct	", ",T1XR2
R6818	T10574	T10563	conj	BB617F,T1XR2
R6819	T10575	T10576	punct	(,accaccaacttgagtacctg
R6820	T10576	T10574	parataxis	accaccaacttgagtacctg,BB617F
R6821	T10577	T10576	nummod	5,accaccaacttgagtacctg
R6822	T10578	T10577	punct	',5
R6823	T10579	T10576	punct	-,accaccaacttgagtacctg
R6824	T10580	T10576	punct	-,accaccaacttgagtacctg
R6825	T10581	T10576	nummod	3,accaccaacttgagtacctg
R6826	T10582	T10576	punct	',accaccaacttgagtacctg
R6827	T10583	T10576	punct	),accaccaacttgagtacctg
R6828	T10584	T10574	cc	and,BB617F
R6829	T10585	T10574	conj	BB617R,BB617F
R6830	T10586	T10587	punct	(,gtatcttgaactgttggttctg
R6831	T10587	T10585	parataxis	gtatcttgaactgttggttctg,BB617R
R6832	T10588	T10587	nummod	5,gtatcttgaactgttggttctg
R6833	T10589	T10588	punct	',5
R6834	T10590	T10587	punct	-,gtatcttgaactgttggttctg
R6835	T10591	T10587	punct	-,gtatcttgaactgttggttctg
R6836	T10592	T10587	nummod	3,gtatcttgaactgttggttctg
R6837	T10593	T10587	punct	',gtatcttgaactgttggttctg
R6838	T10594	T10587	punct	),gtatcttgaactgttggttctg
R6839	T10595	T10503	punct	.,based
R6840	T10597	T10598	prep	For,located
R6841	T10599	T10597	pobj	analysis,For
R6842	T10600	T10599	prep	of,analysis
R6843	T10601	T10602	compound	TACC1,variants
R6844	T10602	T10600	pobj	variants,of
R6845	T10603	T10602	compound	splice,variants
R6846	T10604	T10598	punct	", ",located
R6847	T10605	T10606	det	the,primers
R6848	T10606	T10598	nsubjpass	primers,located
R6849	T10607	T10606	amod	forward,primers
R6850	T10608	T10606	acl	used,primers
R6851	T10609	T10598	auxpass	were,located
R6852	T10610	T10598	prep	in,located
R6853	T10611	T10610	pobj	exon,in
R6854	T10612	T10611	nummod	1b,exon
R6855	T10613	T10611	punct	: ,exon
R6856	T10614	T10615	dep	EF,gagagatgcgaaatcagcg
R6857	T10615	T10611	parataxis	gagagatgcgaaatcagcg,exon
R6858	T10616	T10615	punct	(,gagagatgcgaaatcagcg
R6859	T10617	T10615	nummod	5,gagagatgcgaaatcagcg
R6860	T10618	T10617	punct	',5
R6861	T10619	T10615	punct	-,gagagatgcgaaatcagcg
R6862	T10620	T10615	punct	-,gagagatgcgaaatcagcg
R6863	T10621	T10615	nummod	3,gagagatgcgaaatcagcg
R6864	T10622	T10615	punct	',gagagatgcgaaatcagcg
R6865	T10623	T10615	punct	),gagagatgcgaaatcagcg
R6866	T10624	T10611	punct	", ",exon
R6867	T10625	T10611	appos	Exon,exon
R6868	T10626	T10625	nummod	1d,Exon
R6869	T10627	T10625	punct	: ,Exon
R6870	T10628	T10629	dep	X3F,agtcaaagaaggcatctgcag
R6871	T10629	T10625	parataxis	agtcaaagaaggcatctgcag,Exon
R6872	T10630	T10629	punct	(,agtcaaagaaggcatctgcag
R6873	T10631	T10629	nummod	5,agtcaaagaaggcatctgcag
R6874	T10632	T10631	punct	',5
R6875	T10633	T10629	punct	-,agtcaaagaaggcatctgcag
R6876	T10634	T10629	punct	-,agtcaaagaaggcatctgcag
R6877	T10635	T10629	nummod	3,agtcaaagaaggcatctgcag
R6878	T10636	T10629	punct	',agtcaaagaaggcatctgcag
R6879	T10637	T10629	punct	),agtcaaagaaggcatctgcag
R6880	T10638	T10611	punct	", ",exon
R6881	T10639	T10611	appos	Exon,exon
R6882	T10640	T10639	nummod	1a,Exon
R6883	T10641	T10639	punct	: ,Exon
R6884	T10642	T10643	dep	1DF,ccaagttctgcgccatggg
R6885	T10643	T10639	parataxis	ccaagttctgcgccatggg,Exon
R6886	T10644	T10643	punct	(,ccaagttctgcgccatggg
R6887	T10645	T10643	nummod	5,ccaagttctgcgccatggg
R6888	T10646	T10645	punct	',5
R6889	T10647	T10643	punct	-,ccaagttctgcgccatggg
R6890	T10648	T10643	punct	-,ccaagttctgcgccatggg
R6891	T10649	T10643	nummod	3,ccaagttctgcgccatggg
R6892	T10650	T10643	punct	',ccaagttctgcgccatggg
R6893	T10651	T10643	punct	),ccaagttctgcgccatggg
R6894	T10652	T10598	punct	.,located
R6895	T10654	T10655	det	The,primers
R6896	T10655	T10657	nsubj	primers,were
R6897	T10656	T10655	amod	reverse,primers
R6898	T10658	T10655	acl	used,primers
R6899	T10659	T10657	punct	: ,were
R6900	T10660	T10657	attr	Exon,were
R6901	T10661	T10660	nummod	1,Exon
R6902	T10662	T10660	punct	: ,Exon
R6903	T10663	T10664	dep	X1R,ggatttggtctcggcttgcgaatc
R6904	T10664	T10660	parataxis	ggatttggtctcggcttgcgaatc,Exon
R6905	T10665	T10664	punct	(,ggatttggtctcggcttgcgaatc
R6906	T10666	T10664	nummod	5,ggatttggtctcggcttgcgaatc
R6907	T10667	T10666	punct	',5
R6908	T10668	T10664	punct	-,ggatttggtctcggcttgcgaatc
R6909	T10669	T10664	punct	-,ggatttggtctcggcttgcgaatc
R6910	T10670	T10664	nummod	3,ggatttggtctcggcttgcgaatc
R6911	T10671	T10664	punct	',ggatttggtctcggcttgcgaatc
R6912	T10672	T10664	punct	),ggatttggtctcggcttgcgaatc
R6913	T10673	T10660	punct	", ",Exon
R6914	T10674	T10660	appos	Exon,Exon
R6915	T10675	T10674	nummod	2,Exon
R6916	T10676	T10674	punct	: ,Exon
R6917	T10677	T10678	dep	BX647R,cttgtgattcttggcttttgg
R6918	T10678	T10674	parataxis	cttgtgattcttggcttttgg,Exon
R6919	T10679	T10678	punct	(,cttgtgattcttggcttttgg
R6920	T10680	T10678	nummod	5,cttgtgattcttggcttttgg
R6921	T10681	T10680	punct	',5
R6922	T10682	T10678	punct	-,cttgtgattcttggcttttgg
R6923	T10683	T10678	punct	-,cttgtgattcttggcttttgg
R6924	T10684	T10678	nummod	3,cttgtgattcttggcttttgg
R6925	T10685	T10678	punct	',cttgtgattcttggcttttgg
R6926	T10686	T10678	punct	),cttgtgattcttggcttttgg
R6927	T10687	T10660	punct	", ",Exon
R6928	T10688	T10660	appos	Exon,Exon
R6929	T10689	T10688	nummod	3,Exon
R6930	T10690	T10688	punct	: ,Exon
R6931	T10691	T10692	dep	6SPR,gtcatcgcctcgtcctggagggc
R6932	T10692	T10688	parataxis	gtcatcgcctcgtcctggagggc,Exon
R6933	T10693	T10692	punct	(,gtcatcgcctcgtcctggagggc
R6934	T10694	T10692	nummod	5,gtcatcgcctcgtcctggagggc
R6935	T10695	T10694	punct	',5
R6936	T10696	T10692	punct	-,gtcatcgcctcgtcctggagggc
R6937	T10697	T10692	punct	-,gtcatcgcctcgtcctggagggc
R6938	T10698	T10692	nummod	3,gtcatcgcctcgtcctggagggc
R6939	T10699	T10692	punct	',gtcatcgcctcgtcctggagggc
R6940	T10700	T10692	punct	),gtcatcgcctcgtcctggagggc
R6941	T10701	T10660	punct	", ",Exon
R6942	T10702	T10703	compound	Exon,4a
R6943	T10703	T10660	appos	4a,Exon
R6944	T10704	T10703	punct	: ,4a
R6945	T10705	T10706	dep	1DR,aatttcacttgttcagtagtc
R6946	T10706	T10703	parataxis	aatttcacttgttcagtagtc,4a
R6947	T10707	T10706	punct	(,aatttcacttgttcagtagtc
R6948	T10708	T10706	nummod	5,aatttcacttgttcagtagtc
R6949	T10709	T10708	punct	',5
R6950	T10710	T10706	punct	-,aatttcacttgttcagtagtc
R6951	T10711	T10706	punct	-,aatttcacttgttcagtagtc
R6952	T10712	T10706	nummod	3,aatttcacttgttcagtagtc
R6953	T10713	T10706	punct	',aatttcacttgttcagtagtc
R6954	T10714	T10706	punct	),aatttcacttgttcagtagtc
R6955	T10715	T10660	punct	", ",Exon
R6956	T10716	T10660	appos	Exon,Exon
R6957	T10717	T10716	nummod	5,Exon
R6958	T10718	T10716	punct	: ,Exon
R6959	T10719	T10720	dep	128R,cctgcttctgaggatgaaaacgc
R6960	T10720	T10716	parataxis	cctgcttctgaggatgaaaacgc,Exon
R6961	T10721	T10720	punct	(,cctgcttctgaggatgaaaacgc
R6962	T10722	T10720	nummod	5,cctgcttctgaggatgaaaacgc
R6963	T10723	T10722	punct	',5
R6964	T10724	T10720	punct	-,cctgcttctgaggatgaaaacgc
R6965	T10725	T10720	punct	-,cctgcttctgaggatgaaaacgc
R6966	T10726	T10720	nummod	3,cctgcttctgaggatgaaaacgc
R6967	T10727	T10720	punct	',cctgcttctgaggatgaaaacgc
R6968	T10728	T10720	punct	),cctgcttctgaggatgaaaacgc
R6969	T10729	T10657	punct	.,were
R6970	T10731	T10732	compound	Rabbit,brain
R6971	T10732	T10733	compound	brain,mRNA
R6972	T10733	T10736	nsubjpass	mRNA,obtained
R6973	T10734	T10733	compound	poly,mRNA
R6974	T10735	T10733	compound	A+,mRNA
R6975	T10737	T10733	punct	", ",mRNA
R6976	T10738	T10739	compound	mouse,testis
R6977	T10739	T10733	conj	testis,mRNA
R6978	T10740	T10739	cc	and,testis
R6979	T10741	T10742	amod	human,brain
R6980	T10742	T10743	nmod	brain,RNA
R6981	T10743	T10739	conj	RNA,testis
R6982	T10744	T10743	amod	total,RNA
R6983	T10745	T10736	auxpass	were,obtained
R6984	T10746	T10736	prep	from,obtained
R6985	T10747	T10748	compound	BD,Clontech
R6986	T10748	T10746	pobj	Clontech,from
R6987	T10749	T10748	compound	Bioscience,Clontech
R6988	T10750	T10748	punct	(,Clontech
R6989	T10751	T10752	compound	Palo,Alto
R6990	T10752	T10748	appos	Alto,Clontech
R6991	T10753	T10752	punct	", ",Alto
R6992	T10754	T10752	npadvmod	CA,Alto
R6993	T10755	T10752	punct	", ",Alto
R6994	T10756	T10752	npadvmod	U.S.A.,Alto
R6995	T10757	T10748	punct	),Clontech
R6996	T10758	T10736	punct	.,obtained
R6997	T10760	T10761	amod	Reverse,transcription
R6998	T10761	T10762	nsubjpass	transcription,performed
R6999	T10763	T10761	cc	and,transcription
R7000	T10764	T10761	conj	PCR,transcription
R7001	T10765	T10762	auxpass	was,performed
R7002	T10766	T10767	mark	as,described
R7003	T10767	T10762	advcl	described,performed
R7004	T10768	T10767	advmod	previously,described
R7005	T10769	T10762	punct	", ",performed
R7006	T10770	T10762	advcl	using,performed
R7007	T10771	T10772	preconj	either,μg
R7008	T10772	T10770	dobj	μg,using
R7009	T10773	T10772	nummod	1,μg
R7010	T10774	T10772	prep	of,μg
R7011	T10775	T10776	amod	total,RNA
R7012	T10776	T10774	pobj	RNA,of
R7013	T10777	T10772	cc	or,μg
R7014	T10778	T10779	nummod	50,ng
R7015	T10779	T10772	conj	ng,μg
R7016	T10780	T10779	prep	of,ng
R7017	T10781	T10782	compound	poly,A+
R7018	T10782	T10783	compound	A+,mRNA
R7019	T10783	T10780	pobj	mRNA,of
R7020	T10784	T10770	prep	as,using
R7021	T10785	T10784	pobj	template,as
R7022	T10786	T10785	prep	for,template
R7023	T10787	T10788	amod	first,strand
R7024	T10788	T10789	compound	strand,cDNA
R7025	T10789	T10790	compound	cDNA,synthesis
R7026	T10790	T10786	pobj	synthesis,for
R7027	T10791	T10762	punct	.,performed
R7028	T10793	T10794	compound	PCR,products
R7029	T10794	T10795	nsubjpass	products,cloned
R7030	T10796	T10795	auxpass	were,cloned
R7031	T10797	T10795	prep	into,cloned
R7032	T10798	T10797	pobj	pCR2.1,into
R7033	T10799	T10800	punct	(,Invitrogen
R7034	T10800	T10798	parataxis	Invitrogen,pCR2.1
R7035	T10801	T10800	punct	", ",Invitrogen
R7036	T10802	T10800	npadvmod	Carlsbad,Invitrogen
R7037	T10803	T10800	npadvmod	CA,Invitrogen
R7038	T10804	T10800	punct	", ",Invitrogen
R7039	T10805	T10800	npadvmod	U.S.A.,Invitrogen
R7040	T10806	T10800	punct	),Invitrogen
R7041	T10807	T10795	cc	and,cloned
R7042	T10808	T10795	conj	transformed,cloned
R7043	T10809	T10808	prep	into,transformed
R7044	T10810	T10811	poss	InvαF,competent
R7045	T10811	T10813	amod	competent,cells
R7046	T10812	T10810	case	',InvαF
R7047	T10813	T10809	pobj	cells,into
R7048	T10814	T10795	punct	.,cloned
R7049	T10816	T10817	compound	Plasmid,inserts
R7050	T10817	T10818	nsubjpass	inserts,sequenced
R7051	T10819	T10818	auxpass	were,sequenced
R7052	T10820	T10818	agent	by,sequenced
R7053	T10821	T10822	det	the,Facility
R7054	T10822	T10820	pobj	Facility,by
R7055	T10823	T10824	compound	Roswell,Park
R7056	T10824	T10825	compound	Park,Institute
R7057	T10825	T10822	compound	Institute,Facility
R7058	T10826	T10825	compound	Cancer,Institute
R7059	T10827	T10828	compound	Biopolymer,Core
R7060	T10828	T10822	compound	Core,Facility
R7061	T10829	T10818	punct	.,sequenced
R7062	T10983	T10982	prep	of,Deposition
R7063	T10984	T10985	compound	nucleotide,sequences
R7064	T10985	T10983	pobj	sequences,of
R7065	T10987	T10988	nsubjpass	Sequences,deposited
R7066	T10989	T10987	prep	from,Sequences
R7067	T10990	T10991	det	this,article
R7068	T10991	T10989	pobj	article,from
R7069	T10992	T10988	aux	have,deposited
R7070	T10993	T10988	auxpass	been,deposited
R7071	T10994	T10988	prep	in,deposited
R7072	T10995	T10996	det	the,database
R7073	T10996	T10994	pobj	database,in
R7074	T10997	T10996	compound	GenBank,database
R7075	T10998	T10988	prep	with,deposited
R7076	T10999	T11000	det	the,numbers
R7077	T11000	T10998	pobj	numbers,with
R7078	T11001	T11000	amod	following,numbers
R7079	T11002	T11000	compound	accession,numbers
R7080	T11003	T11000	punct	: ,numbers
R7081	T11004	T11005	nmod	Homo,sapiens
R7082	T11005	T11006	nmod	sapiens,S
R7083	T11006	T11000	appos	S,numbers
R7084	T11007	T11006	nmod	TACC1,S
R7085	T11008	T11009	amod	short,isoform
R7086	T11009	T11006	compound	isoform,S
R7087	T11010	T11011	punct	(,AY177411
R7088	T11011	T11006	parataxis	AY177411,S
R7089	T11012	T11011	punct	),AY177411
R7090	T11013	T11006	punct	", ",S
R7091	T11014	T11015	nmod	Mus,musculus
R7092	T11015	T11016	nmod	musculus,S
R7093	T11016	T11006	appos	S,S
R7094	T11017	T11016	nmod	TACC1,S
R7095	T11018	T11019	amod	short,isoform
R7096	T11019	T11016	compound	isoform,S
R7097	T11020	T11021	punct	(,AY177412
R7098	T11021	T11016	parataxis	AY177412,S
R7099	T11022	T11021	punct	),AY177412
R7100	T11023	T11006	punct	", ",S
R7101	T11024	T11025	nmod	Mus,musculus
R7102	T11025	T11026	nmod	musculus,A
R7103	T11026	T11006	appos	A,S
R7104	T11027	T11026	nmod	TACC1,A
R7105	T11028	T11029	amod	long,isoform
R7106	T11029	T11026	compound	isoform,A
R7107	T11030	T11031	punct	(,AY177413
R7108	T11031	T11026	parataxis	AY177413,A
R7109	T11032	T11031	punct	),AY177413
R7110	T11033	T11006	punct	", ",S
R7111	T11034	T11035	compound	Mus,musculus
R7112	T11035	T11036	compound	musculus,TACC2s
R7113	T11036	T11006	appos	TACC2s,S
R7114	T11037	T11038	punct	(,AY177410
R7115	T11038	T11036	parataxis	AY177410,TACC2s
R7116	T11039	T11038	punct	),AY177410
R7117	T11040	T11006	punct	", ",S
R7118	T11041	T11042	compound	Oryctolagus,cuniculus
R7119	T11042	T11043	compound	cuniculus,TACC3
R7120	T11043	T11006	appos	TACC3,S
R7121	T11044	T11045	punct	(,AY161270
R7122	T11045	T11043	parataxis	AY161270,TACC3
R7123	T11046	T11045	punct	),AY161270
R7124	T11047	T11006	punct	", ",S
R7125	T11048	T11049	compound	Danio,rerio
R7126	T11049	T11050	compound	rerio,TACC3
R7127	T11050	T11006	appos	TACC3,S
R7128	T11051	T11052	punct	(,AY170618
R7129	T11052	T11050	parataxis	AY170618,TACC3
R7130	T11053	T11052	punct	),AY170618
R7131	T11054	T10988	punct	.,deposited
R7132	T11056	T11057	nsubj	Annotations,are
R7133	T11058	T11056	acl	submitted,Annotations
R7134	T11059	T11058	prep	to,submitted
R7135	T11060	T11061	det	the,database
R7136	T11061	T11059	pobj	database,to
R7137	T11062	T11063	amod	Third,party
R7138	T11063	T11061	compound	party,database
R7139	T11064	T11061	compound	annotation,database
R7140	T11065	T11061	prep	at,database
R7141	T11066	T11065	pobj	NCBI,at
R7142	T11067	T11068	mark	as,follows
R7143	T11068	T11057	advcl	follows,are
R7144	T11069	T11057	punct	: ,are
R7145	T11070	T11071	nmod	Rattus,norvegus
R7146	T11071	T11072	nmod	norvegus,A
R7147	T11072	T11057	dep	A,are
R7148	T11073	T11072	nmod	TACC1,A
R7149	T11074	T11075	amod	long,isoform
R7150	T11075	T11072	compound	isoform,A
R7151	T11076	T11077	punct	(,BK001653
R7152	T11077	T11072	parataxis	BK001653,A
R7153	T11078	T11077	punct	),BK001653
R7154	T11079	T11072	punct	", ",A
R7155	T11080	T11081	compound	Takifugu,rubripes
R7156	T11081	T11082	compound	rubripes,TACC1A
R7157	T11082	T11072	appos	TACC1A,A
R7158	T11083	T11084	punct	(,BK000667
R7159	T11084	T11082	parataxis	BK000667,TACC1A
R7160	T11085	T11084	compound	BK000666,BK000667
R7161	T11086	T11084	punct	/,BK000667
R7162	T11087	T11084	punct	),BK000667
R7163	T11088	T11072	punct	", ",A
R7164	T11089	T11090	compound	Takifugu,rubripes
R7165	T11090	T11091	compound	rubripes,TACC1B
R7166	T11091	T11072	appos	TACC1B,A
R7167	T11092	T11093	punct	(,BK000664
R7168	T11093	T11091	parataxis	BK000664,TACC1B
R7169	T11094	T11093	punct	),BK000664
R7170	T11095	T11072	punct	", ",A
R7171	T11096	T11097	compound	Mus,musculus
R7172	T11097	T11098	compound	musculus,TACC2l
R7173	T11098	T11072	appos	TACC2l,A
R7174	T11099	T11100	punct	(,BK001495
R7175	T11100	T11098	parataxis	BK001495,TACC2l
R7176	T11101	T11100	punct	),BK001495
R7177	T11102	T11072	punct	", ",A
R7178	T11103	T11104	compound	Rattus,norvegus
R7179	T11104	T11105	compound	norvegus,TACC2l
R7180	T11105	T11072	appos	TACC2l,A
R7181	T11106	T11107	punct	(,BK001658
R7182	T11107	T11105	parataxis	BK001658,TACC2l
R7183	T11108	T11107	punct	),BK001658
R7184	T11109	T11072	punct	", ",A
R7185	T11110	T11111	compound	Rattus,norvegus
R7186	T11111	T11112	compound	norvegus,TACC2s
R7187	T11112	T11072	appos	TACC2s,A
R7188	T11113	T11114	punct	(,BK001657
R7269	T11434	T11435	amod	Phylogenetic,analysis
R7189	T11114	T11112	parataxis	BK001657,TACC2s
R7190	T11115	T11114	punct	),BK001657
R7191	T11116	T11072	punct	", ",A
R7192	T11117	T11118	compound	Takifugu,rubripes
R7193	T11118	T11119	compound	rubripes,TACC2l
R7194	T11119	T11072	appos	TACC2l,A
R7195	T11120	T11121	punct	(,BK000690
R7196	T11121	T11119	parataxis	BK000690,TACC2l
R7197	T11122	T11121	punct	),BK000690
R7198	T11123	T11072	punct	", ",A
R7199	T11124	T11125	compound	Rattus,norvegus
R7200	T11125	T11126	compound	norvegus,TACC3
R7201	T11126	T11072	appos	TACC3,A
R7202	T11127	T11128	punct	(,BK001491
R7203	T11128	T11126	parataxis	BK001491,TACC3
R7204	T11129	T11128	punct	),BK001491
R7205	T11130	T11072	punct	", ",A
R7206	T11131	T11132	compound	Gallus,gallus
R7207	T11132	T11133	compound	gallus,TACC3
R7208	T11133	T11072	appos	TACC3,A
R7209	T11134	T11135	punct	(,BK001482
R7210	T11135	T11133	parataxis	BK001482,TACC3
R7211	T11136	T11135	punct	),BK001482
R7212	T11137	T11072	punct	", ",A
R7213	T11138	T11139	compound	Silurana,tropicalis
R7214	T11139	T11140	compound	tropicalis,TACC3
R7215	T11140	T11072	appos	TACC3,A
R7216	T11141	T11142	punct	(,BK001481
R7217	T11142	T11140	parataxis	BK001481,TACC3
R7218	T11143	T11142	punct	),BK001481
R7219	T11144	T11072	punct	",",A
R7220	T11145	T11146	compound	Takifugu,rubripes
R7221	T11146	T11147	compound	rubripes,TACC3
R7222	T11147	T11072	appos	TACC3,A
R7223	T11148	T11149	punct	(,BK000649
R7224	T11149	T11147	parataxis	BK000649,TACC3
R7225	T11150	T11149	punct	),BK000649
R7226	T11151	T11072	punct	", ",A
R7227	T11152	T11153	compound	Takifugu,rubripes
R7228	T11153	T11154	compound	rubripes,RHAMM
R7229	T11154	T11072	appos	RHAMM,A
R7230	T11155	T11156	punct	(,BK000676
R7231	T11156	T11154	parataxis	BK000676,RHAMM
R7232	T11157	T11156	punct	),BK000676
R7233	T11158	T11072	punct	", ",A
R7234	T11159	T11160	compound	Ciona,intestinalis
R7235	T11160	T11161	compound	intestinalis,RHAMM
R7236	T11161	T11072	appos	RHAMM,A
R7237	T11162	T11163	punct	(,BK001479
R7238	T11163	T11161	parataxis	BK001479,RHAMM
R7239	T11164	T11163	punct	),BK001479
R7240	T11165	T11072	punct	", ",A
R7241	T11166	T11167	compound	Takifugu,rubripes
R7242	T11167	T11168	compound	rubripes,Keratin
R7243	T11168	T11072	appos	Keratin,A
R7244	T11169	T11170	punct	(,BK000677
R7245	T11170	T11168	parataxis	BK000677,Keratin
R7246	T11171	T11170	punct	),BK000677
R7247	T11172	T11072	punct	", ",A
R7248	T11173	T11174	compound	Takifugu,rubripes
R7249	T11174	T11175	compound	rubripes,TPM1
R7250	T11175	T11072	appos	TPM1,A
R7251	T11176	T11177	punct	(,BAC10576
R7252	T11177	T11175	parataxis	BAC10576,TPM1
R7253	T11178	T11177	punct	),BAC10576
R7254	T11179	T11072	punct	", ",A
R7255	T11180	T11181	compound	Ciona,intestinalis
R7256	T11181	T11182	compound	intestinalis,Kif3b
R7257	T11182	T11072	appos	Kif3b,A
R7258	T11183	T11184	punct	(,BK001492
R7259	T11184	T11182	parataxis	BK001492,Kif3b
R7260	T11185	T11184	punct	),BK001492
R7261	T11186	T11072	punct	", ",A
R7262	T11187	T11188	compound	Ciona,intestinalis
R7263	T11188	T11189	compound	intestinalis,klp2
R7264	T11189	T11072	appos	klp2,A
R7265	T11190	T11191	punct	(,BK001493
R7266	T11191	T11189	parataxis	BK001493,klp2
R7267	T11192	T11191	punct	),BK001493
R7268	T11193	T11057	punct	.,are
R7270	T11437	T11438	prep	In,retrieved
R7271	T11439	T11437	pobj	order,In
R7272	T11440	T11441	aux	to,examine
R7273	T11441	T11439	acl	examine,order
R7274	T11442	T11443	amod	evolutionary,relationships
R7275	T11443	T11441	dobj	relationships,examine
R7276	T11444	T11443	prep	of,relationships
R7277	T11445	T11444	pobj	proteins,of
R7278	T11446	T11445	acl	containing,proteins
R7279	T11447	T11448	amod	coiled,coil
R7280	T11448	T11449	compound	coil,domains
R7281	T11449	T11446	dobj	domains,containing
R7282	T11450	T11438	punct	", ",retrieved
R7283	T11451	T11452	compound	protein,sequences
R7284	T11452	T11438	nsubjpass	sequences,retrieved
R7285	T11453	T11452	acl	representing,sequences
R7286	T11454	T11455	det	the,members
R7287	T11455	T11453	dobj	members,representing
R7288	T11456	T11455	amod	major,members
R7289	T11457	T11455	prep	of,members
R7290	T11458	T11459	det	this,family
R7291	T11459	T11457	pobj	family,of
R7292	T11460	T11459	amod	super,family
R7293	T11461	T11452	punct	", ",sequences
R7294	T11462	T11452	prep	including,sequences
R7295	T11463	T11462	pobj	TACC,including
R7296	T11464	T11463	punct	", ",TACC
R7297	T11465	T11463	conj	RHAMM,TACC
R7298	T11466	T11465	punct	", ",RHAMM
R7299	T11467	T11465	conj	KLP,RHAMM
R7300	T11468	T11467	punct	", ",KLP
R7301	T11469	T11467	conj	keratin,KLP
R7302	T11470	T11469	cc	and,keratin
R7303	T11471	T11469	conj	tropomyosin,keratin
R7304	T11472	T11452	prep	from,sequences
R7305	T11473	T11474	amod	available,vertebrates
R7306	T11474	T11472	pobj	vertebrates,from
R7307	T11475	T11474	cc	and,vertebrates
R7308	T11476	T11477	poss	their,orthologues
R7309	T11477	T11474	conj	orthologues,vertebrates
R7310	T11478	T11477	amod	recognizable,orthologues
R7311	T11479	T11477	prep	from,orthologues
R7312	T11480	T11481	det	the,urochordate
R7313	T11481	T11479	pobj	urochordate,from
R7314	T11482	T11483	compound	Ciona,intestinalis
R7315	T11483	T11481	appos	intestinalis,urochordate
R7316	T11484	T11481	punct	", ",urochordate
R7317	T11485	T11486	compound	Drosophila,melanogaster
R7318	T11486	T11481	conj	melanogaster,urochordate
R7319	T11487	T11486	punct	", ",melanogaster
R7320	T11488	T11489	compound	C.,elegans
R7321	T11489	T11486	conj	elegans,melanogaster
R7322	T11490	T11489	cc	and,elegans
R7323	T11491	T11492	compound	Saccharomyces,cerevisiae
R7324	T11492	T11489	conj	cerevisiae,elegans
R7325	T11493	T11438	auxpass	were,retrieved
R7326	T11494	T11438	preconj	either,retrieved
R7327	T11495	T11438	advmod	directly,retrieved
R7328	T11496	T11438	prep	from,retrieved
R7329	T11497	T11498	compound	NCBI,databases
R7330	T11498	T11496	pobj	databases,from
R7331	T11499	T11498	compound	sequence,databases
R7332	T11500	T11498	punct	", ",databases
R7333	T11501	T11502	advmod	newly,predicted
R7334	T11502	T11498	acl	predicted,databases
R7335	T11503	T11438	cc	or,retrieved
R7336	T11504	T11438	conj	isolated,retrieved
R7337	T11505	T11506	punct	(,see
R7338	T11506	T11504	parataxis	see,isolated
R7339	T11507	T11506	advmod	above,see
R7340	T11508	T11506	punct	),see
R7341	T11509	T11438	punct	.,retrieved
R7342	T11511	T11512	compound	Species,abbreviations
R7343	T11512	T11513	nsubj	abbreviations,are
R7344	T11514	T11515	mark	as,follows
R7345	T11515	T11513	advcl	follows,are
R7346	T11516	T11513	punct	: ,are
R7347	T11517	T11513	dep	hs,are
R7348	T11518	T11517	punct	(,hs
R7349	T11519	T11520	compound	Homo,sapiens
R7350	T11520	T11517	appos	sapiens,hs
R7351	T11521	T11517	punct	),hs
R7352	T11522	T11517	punct	", ",hs
R7353	T11523	T11517	appos	mm,hs
R7354	T11524	T11523	punct	(,mm
R7355	T11525	T11526	compound	Mus,musculus
R7356	T11526	T11523	appos	musculus,mm
R7357	T11527	T11517	punct	),hs
R7358	T11528	T11517	punct	", ",hs
R7359	T11529	T11517	appos	rn,hs
R7360	T11530	T11529	punct	(,rn
R7361	T11531	T11532	compound	Rattus,norvegus
R7362	T11532	T11529	appos	norvegus,rn
R7363	T11533	T11517	punct	),hs
R7364	T11534	T11517	punct	", ",hs
R7365	T11535	T11517	appos	oc,hs
R7366	T11536	T11535	punct	(,oc
R7367	T11537	T11538	compound	Oryctolagus,cuniculus
R7368	T11538	T11535	appos	cuniculus,oc
R7369	T11539	T11517	punct	),hs
R7370	T11540	T11517	punct	", ",hs
R7371	T11541	T11517	appos	gg,hs
R7372	T11542	T11541	punct	(,gg
R7373	T11543	T11544	compound	Gallus,gallus
R7374	T11544	T11541	appos	gallus,gg
R7375	T11545	T11517	punct	),hs
R7376	T11546	T11517	punct	", ",hs
R7377	T11547	T11517	appos	xl,hs
R7378	T11548	T11547	punct	(,xl
R7379	T11549	T11550	compound	Xenopus,laevis
R7380	T11550	T11547	appos	laevis,xl
R7381	T11551	T11517	punct	),hs
R7382	T11552	T11517	punct	", ",hs
R7383	T11553	T11517	appos	st,hs
R7384	T11554	T11553	punct	(,st
R7385	T11555	T11556	compound	Silurana,tropicalis
R7386	T11556	T11553	appos	tropicalis,st
R7387	T11557	T11517	punct	),hs
R7388	T11558	T11517	punct	", ",hs
R7389	T11559	T11517	appos	tr,hs
R7390	T11560	T11559	punct	(,tr
R7391	T11561	T11562	compound	Takifugu,rubripes
R7392	T11562	T11559	appos	rubripes,tr
R7393	T11563	T11517	punct	),hs
R7394	T11564	T11517	punct	", ",hs
R7395	T11565	T11517	appos	dr,hs
R7396	T11566	T11565	punct	(,dr
R7397	T11567	T11568	compound	Danio,rerio
R7398	T11568	T11565	appos	rerio,dr
R7399	T11569	T11517	punct	),hs
R7400	T11570	T11517	punct	", ",hs
R7401	T11571	T11517	appos	ci,hs
R7402	T11572	T11571	punct	(,ci
R7403	T11573	T11574	compound	Ciona,intestinalis
R7404	T11574	T11571	appos	intestinalis,ci
R7405	T11575	T11517	punct	),hs
R7406	T11576	T11517	punct	", ",hs
R7407	T11577	T11517	appos	dm,hs
R7408	T11578	T11577	punct	(,dm
R7409	T11579	T11580	compound	D.,melanogaster
R7410	T11580	T11577	appos	melanogaster,dm
R7411	T11581	T11517	punct	),hs
R7412	T11582	T11517	punct	", ",hs
R7413	T11583	T11517	appos	ce,hs
R7414	T11584	T11583	punct	(,ce
R7415	T11585	T11586	compound	C.,elegans
R7416	T11586	T11583	appos	elegans,ce
R7417	T11587	T11517	punct	),hs
R7418	T11588	T11517	punct	", ",hs
R7419	T11589	T11517	appos	sc,hs
R7420	T11590	T11589	punct	(,sc
R7421	T11591	T11592	compound	Saccharomyces,cerevisiae
R7422	T11592	T11589	appos	cerevisiae,sc
R7423	T11593	T11517	punct	),hs
R7424	T11594	T11513	punct	.,are
R7425	T11596	T11597	det	The,sequences
R7426	T11597	T11598	nsubjpass	sequences,used
R7427	T11599	T11597	acl	identified,sequences
R7428	T11600	T11599	advmod	above,identified
R7429	T11601	T11597	cc	and,sequences
R7430	T11602	T11603	det	the,translations
R7431	T11603	T11597	conj	translations,sequences
R7432	T11604	T11603	amod	following,translations
R7433	T11605	T11603	nmod	protein,translations
R7434	T11606	T11605	cc	or,protein
R7435	T11607	T11605	conj	predicted,protein
R7436	T11608	T11598	auxpass	were,used
R7437	T11609	T11598	prep	for,used
R7438	T11610	T11611	amod	phylogenetic,analysis
R7439	T11611	T11609	pobj	analysis,for
R7440	T11612	T11598	punct	: ,used
R7441	T11613	T11598	dep	hsTACC1A,used
R7442	T11614	T11615	punct	(,NP_006274
R7443	T11615	T11613	parataxis	NP_006274,hsTACC1A
R7444	T11616	T11615	punct	),NP_006274
R7445	T11617	T11613	punct	", ",hsTACC1A
R7446	T11618	T11613	appos	hsTACC2l,hsTACC1A
R7447	T11619	T11620	punct	(,AAO62630
R7448	T11620	T11618	parataxis	AAO62630,hsTACC2l
R7449	T11621	T11620	punct	),AAO62630
R7450	T11622	T11613	appos	hsTACC2s,hsTACC1A
R7451	T11623	T11624	punct	(,AAO62629
R7452	T11624	T11622	parataxis	AAO62629,hsTACC2s
R7453	T11625	T11624	punct	),AAO62629
R7454	T11626	T11613	punct	", ",hsTACC1A
R7455	T11627	T11613	appos	hsTACC3,hsTACC1A
R7456	T11628	T11629	punct	(,NP_006333
R7457	T11629	T11627	parataxis	NP_006333,hsTACC3
R7458	T11630	T11629	punct	),NP_006333
R7459	T11631	T11613	punct	", ",hsTACC1A
R7460	T11632	T11613	appos	mmTACC3,hsTACC1A
R7461	T11633	T11634	punct	(,Q9JJ11
R7462	T11634	T11632	parataxis	Q9JJ11,mmTACC3
R7463	T11635	T11634	punct	),Q9JJ11
R7464	T11636	T11613	punct	", ",hsTACC1A
R7465	T11637	T11613	appos	xlMaskin,hsTACC1A
R7466	T11638	T11639	punct	(,Q9PTG8
R7467	T11639	T11637	parataxis	Q9PTG8,xlMaskin
R7468	T11640	T11639	punct	),Q9PTG8
R7469	T11641	T11613	punct	", ",hsTACC1A
R7470	T11642	T11613	appos	dmTACC,hsTACC1A
R7471	T11643	T11644	punct	(,AAF52099
R7472	T11644	T11642	parataxis	AAF52099,dmTACC
R7473	T11645	T11644	punct	),AAF52099
R7474	T11646	T11613	punct	", ",hsTACC1A
R7475	T11647	T11613	appos	ceTAC1,hsTACC1A
R7476	T11648	T11649	punct	(,NP_497059
R7477	T11649	T11647	parataxis	NP_497059,ceTAC1
R7478	T11650	T11649	punct	),NP_497059
R7479	T11651	T11613	punct	", ",hsTACC1A
R7480	T11652	T11613	appos	scSPC72,hsTACC1A
R7481	T11653	T11654	punct	(,NP_009352
R7482	T11654	T11652	parataxis	NP_009352,scSPC72
R7483	T11655	T11654	punct	),NP_009352
R7484	T11656	T11613	punct	", ",hsTACC1A
R7485	T11657	T11613	appos	hsRHAMM,hsTACC1A
R7486	T11658	T11659	punct	(,NP_036616
R7487	T11659	T11657	parataxis	NP_036616,hsRHAMM
R7488	T11660	T11659	punct	),NP_036616
R7489	T11661	T11613	punct	", ",hsTACC1A
R7490	T11662	T11613	appos	mmRHAMM,hsTACC1A
R7491	T11663	T11664	punct	(,NP_038580
R7492	T11664	T11662	parataxis	NP_038580,mmRHAMM
R7493	T11665	T11664	punct	),NP_038580
R7494	T11666	T11613	punct	", ",hsTACC1A
R7495	T11667	T11613	appos	rnRHAMM,hsTACC1A
R7496	T11668	T11669	punct	(,NP_037096
R7497	T11669	T11667	parataxis	NP_037096,rnRHAMM
R7498	T11670	T11669	punct	),NP_037096
R7499	T11671	T11613	punct	", ",hsTACC1A
R7500	T11672	T11613	appos	drRHAMM,hsTACC1A
R7501	T11673	T11674	punct	(,AAQ97980
R7502	T11674	T11672	parataxis	AAQ97980,drRHAMM
R7503	T11675	T11674	punct	),AAQ97980
R7504	T11676	T11613	punct	", ",hsTACC1A
R7505	T11677	T11613	appos	hsKeratin,hsTACC1A
R7506	T11678	T11679	punct	(,CAB76828
R7507	T11679	T11677	parataxis	CAB76828,hsKeratin
R7508	T11680	T11679	punct	),CAB76828
R7509	T11681	T11613	punct	", ",hsTACC1A
R7510	T11682	T11613	appos	mmKeratin,hsTACC1A
R7511	T11683	T11684	punct	(,A61368
R7512	T11684	T11682	parataxis	A61368,mmKeratin
R7513	T11685	T11684	punct	),A61368
R7514	T11686	T11613	punct	", ",hsTACC1A
R7515	T11687	T11613	appos	rnKeratin,hsTACC1A
R7516	T11688	T11689	punct	(,XP_235679
R7517	T11689	T11687	parataxis	XP_235679,rnKeratin
R7518	T11690	T11689	punct	),XP_235679
R7519	T11691	T11613	punct	", ",hsTACC1A
R7520	T11692	T11613	appos	hsTPM1,hsTACC1A
R7521	T11693	T11694	punct	(,NP_000357
R7522	T11694	T11692	parataxis	NP_000357,hsTPM1
R7523	T11695	T11694	punct	),NP_000357
R7524	T11696	T11613	punct	", ",hsTACC1A
R7525	T11697	T11613	appos	mmTPM1,hsTACC1A
R7526	T11698	T11699	punct	(,NP_077745
R7527	T11699	T11697	parataxis	NP_077745,mmTPM1
R7528	T11700	T11699	punct	),NP_077745
R7529	T11701	T11613	punct	", ",hsTACC1A
R7530	T11702	T11613	appos	rnTPM1,hsTACC1A
R7531	T11703	T11704	punct	(,NP_62004
R7532	T11704	T11702	parataxis	NP_62004,rnTPM1
R7533	T11705	T11613	punct	", ",hsTACC1A
R7534	T11706	T11613	appos	drTPM1,hsTACC1A
R7535	T11707	T11708	punct	(,NP_571180
R7536	T11708	T11706	parataxis	NP_571180,drTPM1
R7537	T11709	T11708	punct	),NP_571180
R7538	T11710	T11613	appos	dmTPM1,hsTACC1A
R7539	T11711	T11712	punct	(,P06754
R7540	T11712	T11710	parataxis	P06754,dmTPM1
R7541	T11713	T11712	punct	),P06754
R7542	T11714	T11613	punct	", ",hsTACC1A
R7543	T11715	T11613	appos	ceTPM,hsTACC1A
R7544	T11716	T11717	punct	(,NP_493540
R7545	T11717	T11715	parataxis	NP_493540,ceTPM
R7546	T11718	T11717	punct	),NP_493540
R7547	T11719	T11613	appos	scTPM1,hsTACC1A
R7548	T11720	T11721	punct	(,P17536
R7549	T11721	T11719	parataxis	P17536,scTPM1
R7550	T11722	T11721	punct	),P17536
R7551	T11723	T11613	punct	", ",hsTACC1A
R7552	T11724	T11613	appos	hsKLP2,hsTACC1A
R7553	T11725	T11726	punct	(,BAB03309
R7554	T11726	T11724	parataxis	BAB03309,hsKLP2
R7555	T11727	T11726	punct	),BAB03309
R7556	T11728	T11613	punct	", ",hsTACC1A
R7557	T11729	T11613	appos	rnKIF15,hsTACC1A
R7558	T11730	T11731	punct	(,AAP44513
R7559	T11731	T11729	parataxis	AAP44513,rnKIF15
R7560	T11732	T11731	punct	),AAP44513
R7561	T11733	T11613	punct	", ",hsTACC1A
R7562	T11734	T11613	appos	xlKLP2,hsTACC1A
R7563	T11735	T11736	punct	(,CAA08879
R7564	T11736	T11734	parataxis	CAA08879,xlKLP2
R7565	T11737	T11736	punct	),CAA08879
R7566	T11738	T11613	punct	", ",hsTACC1A
R7567	T11739	T11613	appos	dmKLP2,hsTACC1A
R7568	T11740	T11741	punct	(,NP_476818
R7569	T11741	T11739	parataxis	NP_476818,dmKLP2
R7570	T11742	T11741	punct	),NP_476818
R7571	T11743	T11613	punct	", ",hsTACC1A
R7572	T11744	T11613	appos	ceKLP18,hsTACC1A
R7573	T11745	T11746	punct	(,AA034669
R7574	T11746	T11744	parataxis	AA034669,ceKLP18
R7575	T11747	T11746	punct	),AA034669
R7576	T11748	T11613	punct	", ",hsTACC1A
R7577	T11749	T11613	appos	hsKIF3A,hsTACC1A
R7578	T11750	T11751	punct	(,Q9Y496
R7579	T11751	T11749	parataxis	Q9Y496,hsKIF3A
R7580	T11752	T11751	punct	),Q9Y496
R7581	T11753	T11613	punct	", ",hsTACC1A
R7582	T11754	T11613	appos	mmKIF3A,hsTACC1A
R7583	T11755	T11756	punct	(,NP_032469
R7584	T11756	T11754	parataxis	NP_032469,mmKIF3A
R7585	T11757	T11756	punct	),NP_032469
R7586	T11758	T11613	punct	", ",hsTACC1A
R7587	T11759	T11613	appos	rnKIF3A,hsTACC1A
R7588	T11760	T11761	punct	(,XP_340797
R7589	T11761	T11759	parataxis	XP_340797,rnKIF3A
R7590	T11762	T11761	punct	),XP_340797
R7591	T11763	T11613	punct	", ",hsTACC1A
R7592	T11764	T11613	appos	xlKIF3A,hsTACC1A
R7593	T11765	T11766	punct	(,CAA08879
R7594	T11766	T11764	parataxis	CAA08879,xlKIF3A
R7595	T11767	T11766	punct	),CAA08879
R7596	T11768	T11613	punct	", ",hsTACC1A
R7597	T11769	T11613	appos	ceKLP11,hsTACC1A
R7598	T11770	T11771	punct	(,NP_741473
R7599	T11771	T11769	parataxis	NP_741473,ceKLP11
R7600	T11772	T11771	punct	),NP_741473
R7601	T11773	T11613	punct	", ",hsTACC1A
R7602	T11774	T11613	appos	ciKIF3,hsTACC1A
R7603	T11775	T11776	punct	(,ci0100148992
R7604	T11776	T11774	parataxis	ci0100148992,ciKIF3
R7605	T11777	T11776	punct	),ci0100148992
R7606	T11778	T11613	punct	", ",hsTACC1A
R7607	T11779	T11613	appos	hsKIF3B,hsTACC1A
R7608	T11780	T11781	punct	(,NP_004789
R7609	T11781	T11779	parataxis	NP_004789,hsKIF3B
R7610	T11782	T11781	punct	),NP_004789
R7611	T11783	T11613	punct	", ",hsTACC1A
R7612	T11784	T11613	appos	mmKIF3B,hsTACC1A
R7613	T11785	T11786	punct	(,NP_004789
R7614	T11786	T11784	parataxis	NP_004789,mmKIF3B
R7615	T11787	T11786	punct	),NP_004789
R7616	T11788	T11613	punct	", ",hsTACC1A
R7617	T11789	T11613	appos	rnKIF3B,hsTACC1A
R7618	T11790	T11791	punct	(,XP_215883
R7619	T11791	T11789	parataxis	XP_215883,rnKIF3B
R7620	T11792	T11791	punct	),XP_215883
R7621	T11793	T11613	punct	", ",hsTACC1A
R7622	T11794	T11613	appos	dmKIF3B,hsTACC1A
R7623	T11795	T11796	punct	(,NP_524029
R7624	T11796	T11794	parataxis	NP_524029,dmKIF3B
R7625	T11797	T11796	punct	),NP_524029
R7626	T11798	T11613	punct	", ",hsTACC1A
R7627	T11799	T11613	appos	hsKIF3C,hsTACC1A
R7628	T11800	T11801	punct	(,NP_002245
R7629	T11801	T11799	parataxis	NP_002245,hsKIF3C
R7630	T11802	T11801	punct	),NP_002245
R7631	T11803	T11613	punct	", ",hsTACC1A
R7632	T11804	T11613	appos	mmKIF3C,hsTACC1A
R7633	T11805	T11806	punct	(,NP_032471
R7634	T11806	T11804	parataxis	NP_032471,mmKIF3C
R7635	T11807	T11806	punct	),NP_032471
R7636	T11808	T11613	punct	", ",hsTACC1A
R7637	T11809	T11613	appos	rnKIF3C,hsTACC1A
R7638	T11810	T11811	punct	(,NP_445938
R7639	T11811	T11809	parataxis	NP_445938,rnKIF3C
R7640	T11812	T11811	punct	),NP_445938
R7641	T11813	T11613	punct	", ",hsTACC1A
R7642	T11814	T11613	appos	dmKIF3C,hsTACC1A
R7643	T11815	T11816	punct	(,NP_651939
R7644	T11816	T11814	parataxis	NP_651939,dmKIF3C
R7645	T11817	T11816	punct	),NP_651939
R7646	T11818	T11598	punct	.,used
R7647	T11820	T11821	det	These,sequences
R7648	T11821	T11823	nsubjpass	sequences,aligned
R7649	T11822	T11821	compound	protein,sequences
R7650	T11824	T11823	auxpass	were,aligned
R7651	T11825	T11823	advmod	initially,aligned
R7652	T11826	T11823	prep	with,aligned
R7653	T11827	T11828	compound	CLUSTAL,X
R7654	T11828	T11826	pobj	X,with
R7655	T11829	T11830	punct	[,38
R7656	T11830	T11823	parataxis	38,aligned
R7657	T11831	T11830	punct	],38
R7658	T11832	T11823	punct	.,aligned
R7659	T11834	T11835	amod	Minor,adjustments
R7660	T11835	T11836	nsubjpass	adjustments,made
R7661	T11836	T11847	ccomp	made,saved
R7662	T11837	T11835	prep	to,adjustments
R7663	T11838	T11839	amod	certain,regions
R7664	T11839	T11837	pobj	regions,to
R7665	T11840	T11839	prep	of,regions
R7666	T11841	T11842	det	the,alignment
R7667	T11842	T11840	pobj	alignment,of
R7668	T11843	T11835	prep	for,adjustments
R7669	T11844	T11845	compound	optimization,purposes
R7670	T11845	T11843	pobj	purposes,for
R7671	T11846	T11836	auxpass	were,made
R7672	T11848	T11836	prep	based,made
R7673	T11849	T11848	prep	on,based
R7674	T11850	T11851	amod	pairwise,alignments
R7675	T11851	T11849	pobj	alignments,on
R7676	T11852	T11847	punct	", ",saved
R7677	T11853	T11854	det	the,output
R7678	T11854	T11847	nsubj	output,saved
R7679	T11855	T11847	prep	in,saved
R7680	T11856	T11857	compound	PHYLIP,format
R7681	T11857	T11855	pobj	format,in
R7682	T11858	T11847	punct	", ",saved
R7683	T11859	T11860	prep	after,calculated
R7684	T11860	T11847	advcl	calculated,saved
R7685	T11861	T11859	pobj	which,after
R7686	T11862	T11860	punct	", ",calculated
R7687	T11863	T11864	det	the,distances
R7688	T11864	T11860	nsubjpass	distances,calculated
R7689	T11865	T11864	prep	between,distances
R7690	T11866	T11865	pobj	proteins,between
R7691	T11867	T11860	auxpass	were,calculated
R7692	T11868	T11860	advcl	using,calculated
R7693	T11869	T11870	compound	Poisson,correction
R7694	T11870	T11868	dobj	correction,using
R7695	T11871	T11860	cc	and,calculated
R7696	T11872	T11873	det	the,trees
R7697	T11873	T11875	nsubjpass	trees,inferred
R7698	T11874	T11873	amod	Unrooted,trees
R7699	T11875	T11860	conj	inferred,calculated
R7700	T11876	T11875	auxpass	were,inferred
R7701	T11877	T11875	prep	with,inferred
R7702	T11878	T11879	det	the,method
R7703	T11879	T11877	pobj	method,with
R7704	T11880	T11879	compound	NJ,method
R7705	T11881	T11875	cc	and,inferred
R7706	T11882	T11883	advmod	then,displayed
R7707	T11883	T11875	conj	displayed,inferred
R7708	T11884	T11883	advcl	using,displayed
R7709	T11885	T11884	dobj	TreeView,using
R7710	T11886	T11887	punct	[,39
R7711	T11887	T11883	parataxis	39,displayed
R7712	T11888	T11887	punct	],39
R7713	T11889	T11847	punct	.,saved
R7714	T11891	T11892	compound	Bootstrap,values
R7715	T11892	T11893	nsubjpass	values,shown
R7716	T11894	T11892	prep	above,values
R7717	T11895	T11894	pobj	700,above
R7718	T11896	T11892	prep	for,values
R7719	T11897	T11898	nummod	1000,trials
R7720	T11898	T11896	pobj	trials,for
R7721	T11899	T11893	auxpass	are,shown
R7722	T11900	T11893	prep	at,shown
R7723	T11901	T11902	det	the,node
R7724	T11902	T11900	pobj	node,at
R7725	T11903	T11893	punct	.,shown
R7726	T11905	T11906	aux	To,validate
R7727	T11906	T11907	advcl	validate,analyzed
R7728	T11908	T11909	det	the,tree
R7729	T11909	T11906	dobj	tree,validate
R7730	T11910	T11907	punct	", ",analyzed
R7731	T11911	T11912	det	the,set
R7732	T11912	T11907	nsubjpass	set,analyzed
R7733	T11913	T11912	amod	same,set
R7734	T11914	T11912	compound	sequence,set
R7735	T11915	T11907	auxpass	was,analyzed
R7736	T11916	T11907	prep	with,analyzed
R7737	T11917	T11916	pobj	tools,with
R7738	T11918	T11917	prep	in,tools
R7739	T11919	T11920	det	the,package
R7740	T11920	T11918	pobj	package,in
R7741	T11921	T11920	compound	PHYLIP,package
R7742	T11922	T11923	punct	[,40
R7743	T11923	T11907	parataxis	40,analyzed
R7744	T11924	T11923	punct	],40
R7745	T11925	T11907	punct	", ",analyzed
R7746	T11926	T11907	advcl	using,analyzed
R7747	T11927	T11926	dobj	PRODIST,using
R7748	T11928	T11927	acl	followed,PRODIST
R7749	T11929	T11928	agent	by,followed
R7750	T11930	T11929	pobj	FITCH,by
R7751	T11931	T11930	cc	or,FITCH
R7752	T11932	T11930	conj	NEIGNBOR,FITCH
R7753	T11933	T11926	cc	and,using
R7754	T11934	T11935	dep	tree,displaying
R7755	T11935	T11926	conj	displaying,using
R7756	T11936	T11935	advcl	using,displaying
R7757	T11937	T11936	dobj	TreeView,using
R7758	T11938	T11907	punct	.,analyzed
R7759	T11940	T11941	det	This,method
R7760	T11941	T11943	nsubj	method,produced
R7761	T11942	T11941	amod	additional,method
R7762	T11944	T11943	dobj	trees,produced
R7763	T11945	T11944	prep	with,trees
R7764	T11946	T11947	advmod	essentially,topology
R7765	T11947	T11945	pobj	topology,with
R7766	T11948	T11947	det	the,topology
R7767	T11949	T11947	amod	same,topology
R7768	T11950	T11951	punct	(,shown
R7769	T11951	T11943	parataxis	shown,produced
R7770	T11952	T11951	nsubj	data,shown
R7771	T11953	T11951	neg	not,shown
R7772	T11954	T11951	punct	),shown
R7773	T11955	T11943	punct	.,produced
R7774	T12120	T12121	advmod	In,vitro
R7775	T12121	T12122	amod	vitro,interaction
R7776	T12123	T12122	prep	of,interaction
R7777	T12124	T12123	pobj	TACC2,of
R7778	T12125	T12124	cc	and,TACC2
R7779	T12126	T12124	conj	RXRβ3,TACC2
R7780	T12128	T12129	det	The,cDNA
R7781	T12129	T12131	nsubjpass	cDNA,cloned
R7782	T12130	T12129	compound	TACC2,cDNA
R7783	T12132	T12131	auxpass	was,cloned
R7784	T12133	T12131	prep	into,cloned
R7785	T12134	T12135	compound	GST,pGEX5X2
R7786	T12135	T12133	pobj	pGEX5X2,into
R7787	T12136	T12135	compound	fusion,pGEX5X2
R7788	T12137	T12135	compound	vector,pGEX5X2
R7789	T12138	T12139	punct	(,Biosciences
R7790	T12139	T12131	parataxis	Biosciences,cloned
R7791	T12140	T12139	compound	Amersham,Biosciences
R7792	T12141	T12139	punct	", ",Biosciences
R7793	T12142	T12139	npadvmod	Piscataway,Biosciences
R7794	T12143	T12139	punct	", ",Biosciences
R7795	T12144	T12139	npadvmod	NJ,Biosciences
R7796	T12145	T12139	punct	", ",Biosciences
R7797	T12146	T12139	npadvmod	USA,Biosciences
R7798	T12147	T12139	punct	),Biosciences
R7799	T12148	T12131	punct	.,cloned
R7800	T12150	T12151	nmod	GST,proteins
R7801	T12151	T12156	nsubjpass	proteins,expressed
R7802	T12152	T12150	cc	and,GST
R7803	T12153	T12154	compound	GST,TACC2
R7804	T12154	T12150	conj	TACC2,GST
R7805	T12155	T12154	punct	-,TACC2
R7806	T12157	T12156	auxpass	were,expressed
R7807	T12158	T12156	prep	in,expressed
R7808	T12159	T12160	nmod	E.,coli
R7809	T12160	T12161	nmod	coli,S
R7810	T12161	T12158	pobj	S,in
R7811	T12162	T12161	nmod	BL21,S
R7812	T12163	T12164	punct	(,DE3
R7813	T12164	T12161	parataxis	DE3,S
R7814	T12165	T12164	punct	),DE3
R7815	T12166	T12161	nmod	plys,S
R7816	T12167	T12161	punct	"""",S
R7817	T12168	T12161	punct	"""",S
R7818	T12169	T12156	prep	with,expressed
R7819	T12170	T12171	nummod	1,mM
R7820	T12171	T12172	compound	mM,IPTG
R7821	T12172	T12169	pobj	IPTG,with
R7822	T12173	T12172	prep	at,IPTG
R7823	T12174	T12175	nummod	37,°C
R7824	T12175	T12176	compound	°C,shaker
R7825	T12176	T12173	pobj	shaker,at
R7826	T12177	T12172	prep	for,IPTG
R7827	T12178	T12179	nummod	2,hrs
R7828	T12179	T12177	pobj	hrs,for
R7829	T12180	T12156	punct	.,expressed
R7830	T12182	T12183	nsubjpass	Cells,harvested
R7831	T12184	T12185	punct	(,ml
R7832	T12185	T12182	parataxis	ml,Cells
R7833	T12186	T12185	nummod	50,ml
R7834	T12187	T12185	punct	),ml
R7835	T12188	T12183	auxpass	were,harvested
R7836	T12189	T12183	cc	and,harvested
R7837	T12190	T12183	conj	resuspended,harvested
R7838	T12191	T12190	prep	in,resuspended
R7839	T12192	T12193	nummod	5,ml
R7840	T12193	T12191	pobj	ml,in
R7841	T12194	T12193	prep	of,ml
R7842	T12195	T12196	nummod	20,mM
R7843	T12196	T12197	compound	mM,HCl
R7844	T12197	T12194	pobj	HCl,of
R7845	T12198	T12197	compound	Tris,HCl
R7846	T12199	T12197	punct	-,HCl
R7847	T12200	T12197	npadvmod	pH.8.0,HCl
R7848	T12201	T12197	punct	", ",HCl
R7849	T12202	T12203	nummod	200,mM
R7850	T12203	T12204	compound	mM,NaCl
R7851	T12204	T12197	appos	NaCl,HCl
R7852	T12205	T12197	punct	", ",HCl
R7853	T12206	T12207	nummod	1,mM
R7854	T12207	T12208	compound	mM,EDTA
R7855	T12208	T12197	appos	EDTA,HCl
R7856	T12209	T12208	npadvmod	pH8.0,EDTA
R7857	T12210	T12197	punct	", ",HCl
R7858	T12211	T12212	compound	Protease,inhibitor
R7859	T12212	T12213	compound	inhibitor,set
R7860	T12213	T12197	appos	set,HCl
R7861	T12214	T12213	nummod	III,set
R7862	T12215	T12216	punct	(,Calbiochem
R7863	T12216	T12213	parataxis	Calbiochem,set
R7864	T12217	T12216	punct	),Calbiochem
R7865	T12218	T12183	punct	.,harvested
R7866	T12220	T12221	det	The,cells
R7867	T12221	T12222	nsubjpass	cells,lysed
R7868	T12223	T12222	auxpass	were,lysed
R7869	T12224	T12222	prep	by,lysed
R7870	T12225	T12224	pobj	sonication,by
R7871	T12226	T12222	cc	and,lysed
R7872	T12227	T12228	nsubj	lysate,cleared
R7873	T12228	T12222	conj	cleared,lysed
R7874	T12229	T12228	prep	by,cleared
R7875	T12230	T12229	pobj	centrifugation,by
R7876	T12231	T12230	prep	at,centrifugation
R7877	T12232	T12233	nummod	7500,rpm
R7878	T12233	T12231	pobj	rpm,at
R7879	T12234	T12230	prep	at,centrifugation
R7880	T12235	T12236	nummod	4,°C
R7881	T12236	T12234	pobj	°C,at
R7882	T12237	T12230	prep	for,centrifugation
R7883	T12238	T12239	nummod	15,min
R7884	T12239	T12237	pobj	min,for
R7885	T12240	T12228	punct	.,cleared
R7886	T12242	T12243	det	The,lysate
R7887	T12243	T12245	nsubjpass	lysate,immobilized
R7888	T12244	T12243	amod	cleared,lysate
R7889	T12246	T12245	auxpass	was,immobilized
R7890	T12247	T12245	prep	on,immobilized
R7891	T12248	T12249	compound	glutathione,sepharose
R7892	T12249	T12250	compound	sepharose,beads
R7893	T12250	T12247	pobj	beads,on
R7894	T12251	T12245	prep	in,immobilized
R7895	T12252	T12253	nummod	3,ml
R7896	T12253	T12251	pobj	ml,in
R7897	T12254	T12253	prep	of,ml
R7898	T12255	T12256	nummod	20,mM
R7899	T12256	T12257	compound	mM,HCl
R7900	T12257	T12254	pobj	HCl,of
R7901	T12258	T12257	compound	Tris,HCl
R7902	T12259	T12257	punct	-,HCl
R7903	T12260	T12257	npadvmod	pH.8.0,HCl
R7904	T12261	T12257	punct	", ",HCl
R7905	T12262	T12263	nummod	200,mM
R7906	T12263	T12264	compound	mM,NaCl
R7907	T12264	T12257	appos	NaCl,HCl
R7908	T12265	T12257	punct	", ",HCl
R7909	T12266	T12267	nummod	1,mM
R7910	T12267	T12268	compound	mM,EDTA
R7911	T12268	T12257	appos	EDTA,HCl
R7912	T12269	T12268	npadvmod	pH8.0,EDTA
R7913	T12270	T12245	punct	),immobilized
R7914	T12271	T12245	punct	.,immobilized
R7915	T12273	T12274	compound	RXRβ3,cDNA
R7916	T12274	T12275	nsubjpass	cDNA,cloned
R7917	T12276	T12275	auxpass	was,cloned
R7918	T12277	T12275	prep	into,cloned
R7919	T12278	T12279	compound	pET,28C
R7920	T12279	T12277	pobj	28C,into
R7921	T12280	T12279	punct	(,28C
R7922	T12281	T12279	punct	+,28C
R7923	T12282	T12279	punct	),28C
R7924	T12283	T12284	punct	(,Invitrogen
R7925	T12284	T12279	parataxis	Invitrogen,28C
R7926	T12285	T12284	punct	", ",Invitrogen
R7927	T12286	T12284	npadvmod	Carlsbad,Invitrogen
R7928	T12287	T12284	punct	", ",Invitrogen
R7929	T12288	T12284	npadvmod	CA,Invitrogen
R7930	T12289	T12284	punct	", ",Invitrogen
R7931	T12290	T12284	npadvmod	USA,Invitrogen
R7932	T12291	T12284	punct	),Invitrogen
R7933	T12292	T12275	cc	and,cloned
R7934	T12293	T12294	nsubj	protein,synthesized
R7935	T12294	T12275	conj	synthesized,cloned
R7936	T12295	T12294	prep	by,synthesized
R7937	T12296	T12297	nmod	TNT,kit
R7938	T12297	T12295	pobj	kit,by
R7939	T12298	T12299	advmod	quick,coupled
R7940	T12299	T12297	amod	coupled,kit
R7941	T12300	T12301	compound	transcription,translation
R7942	T12301	T12297	compound	translation,kit
R7943	T12302	T12301	punct	/,translation
R7944	T12303	T12297	compound	system,kit
R7945	T12304	T12305	punct	(,Promega
R7946	T12305	T12297	parataxis	Promega,kit
R7947	T12306	T12305	punct	),Promega
R7948	T12307	T12294	cc	and,synthesized
R7949	T12308	T12294	conj	radiolabeled,synthesized
R7950	T12309	T12308	prep	with,radiolabeled
R7951	T12310	T12311	compound	35S,methionine
R7952	T12311	T12309	pobj	methionine,with
R7953	T12312	T12308	prep	according,radiolabeled
R7954	T12313	T12312	prep	to,according
R7955	T12314	T12315	poss	manufacturer,instructions
R7956	T12315	T12313	pobj	instructions,to
R7957	T12316	T12314	case	's,manufacturer
R7958	T12317	T12294	punct	.,synthesized
R7959	T12319	T12320	nummod	100,μl
R7960	T12320	T12321	nsubjpass	μl,incubated
R7961	T12322	T12320	prep	of,μl
R7962	T12323	T12324	advmod	in,vitro
R7963	T12324	T12325	advmod	vitro,translated
R7964	T12325	T12326	amod	translated,protein
R7965	T12326	T12322	pobj	protein,of
R7966	T12327	T12326	compound	RXRβ3,protein
R7967	T12328	T12320	prep	in,μl
R7968	T12329	T12330	nummod	1,ml
R7969	T12330	T12328	pobj	ml,in
R7970	T12331	T12330	prep	of,ml
R7971	T12332	T12333	nummod	20,mM
R7972	T12333	T12334	compound	mM,HCl
R7973	T12334	T12331	pobj	HCl,of
R7974	T12335	T12334	compound	Tris,HCl
R7975	T12336	T12334	punct	-,HCl
R7976	T12337	T12334	npadvmod	pH.8.0,HCl
R7977	T12338	T12334	punct	", ",HCl
R7978	T12339	T12340	nummod	200,mM
R7979	T12340	T12341	compound	mM,NaCl
R7980	T12341	T12334	appos	NaCl,HCl
R7981	T12342	T12334	punct	", ",HCl
R7982	T12343	T12344	nummod	1,mM
R7983	T12344	T12345	compound	mM,EDTA
R7984	T12345	T12334	appos	EDTA,HCl
R7985	T12346	T12345	npadvmod	pH8.0,EDTA
R7986	T12347	T12321	auxpass	was,incubated
R7987	T12348	T12321	prep	at,incubated
R7988	T12349	T12350	nummod	4,°C
R7989	T12350	T12348	pobj	°C,at
R7990	T12351	T12321	prep	with,incubated
R7991	T12352	T12353	amod	immobilized,TACC2
R7992	T12353	T12351	pobj	TACC2,with
R7993	T12354	T12353	compound	GST,TACC2
R7994	T12355	T12353	punct	-,TACC2
R7995	T12356	T12353	cc	or,TACC2
R7996	T12357	T12353	conj	GST,TACC2
R7997	T12358	T12321	prep	for,incubated
R7998	T12359	T12360	nummod	90,min
R7999	T12360	T12358	pobj	min,for
R8000	T12361	T12321	punct	.,incubated
R8001	T12363	T12364	amod	Unbound,RXRβ3
R8002	T12364	T12365	nsubjpass	RXRβ3,removed
R8003	T12366	T12365	auxpass	was,removed
R8004	T12367	T12365	prep	by,removed
R8005	T12368	T12367	pcomp	washing,by
R8006	T12369	T12370	nummod	three,times
R8007	T12370	T12368	npadvmod	times,washing
R8008	T12371	T12368	prep	with,washing
R8009	T12372	T12373	nummod	20,mM
R8010	T12373	T12374	compound	mM,HCl
R8011	T12374	T12371	pobj	HCl,with
R8012	T12375	T12374	compound	Tris,HCl
R8013	T12376	T12374	punct	-,HCl
R8014	T12377	T12374	npadvmod	pH.8.0,HCl
R8015	T12378	T12374	punct	", ",HCl
R8016	T12379	T12380	nummod	200,mM
R8017	T12380	T12381	compound	mM,NaCl
R8018	T12381	T12374	appos	NaCl,HCl
R8019	T12382	T12374	punct	", ",HCl
R8020	T12383	T12384	nummod	1,mM
R8021	T12384	T12385	compound	mM,EDTA
R8022	T12385	T12374	appos	EDTA,HCl
R8023	T12386	T12385	npadvmod	pH8.0,EDTA
R8024	T12387	T12365	punct	.,removed
R8025	T12389	T12390	compound	Bound,proteins
R8026	T12390	T12391	nsubjpass	proteins,eluted
R8027	T12392	T12391	auxpass	were,eluted
R8028	T12393	T12391	prep	from,eluted
R8029	T12394	T12395	det	the,beads
R8030	T12395	T12393	pobj	beads,from
R8031	T12396	T12391	prep	at,eluted
R8032	T12397	T12398	compound	room,temperature
R8033	T12398	T12396	pobj	temperature,at
R8034	T12399	T12391	prep	for,eluted
R8035	T12400	T12401	nummod	10,min
R8036	T12401	T12399	pobj	min,for
R8037	T12402	T12391	prep	in,eluted
R8038	T12403	T12404	compound	elution,buffer
R8039	T12404	T12402	pobj	buffer,in
R8040	T12405	T12406	punct	(,HCl
R8041	T12406	T12404	parataxis	HCl,buffer
R8042	T12407	T12408	nummod	100,mM
R8043	T12408	T12406	compound	mM,HCl
R8044	T12409	T12406	compound	Tris,HCl
R8045	T12410	T12406	punct	", ",HCl
R8046	T12411	T12406	npadvmod	pH8.0,HCl
R8047	T12412	T12406	punct	", ",HCl
R8048	T12413	T12414	nummod	20,mM
R8049	T12414	T12415	nmod	mM,glutathione
R8050	T12415	T12406	appos	glutathione,HCl
R8051	T12416	T12415	amod	reduced,glutathione
R8052	T12417	T12406	punct	),HCl
R8053	T12418	T12391	punct	.,eluted
R8054	T12420	T12421	det	The,proteins
R8055	T12421	T12422	nsubjpass	proteins,analyzed
R8056	T12423	T12422	auxpass	were,analyzed
R8057	T12424	T12422	prep	on,analyzed
R8058	T12425	T12426	nummod	12,%
R8059	T12426	T12427	compound	%,gels
R8060	T12427	T12424	pobj	gels,on
R8061	T12428	T12427	compound	SDS,gels
R8062	T12429	T12427	compound	polyacrylamide,gels
R8063	T12430	T12422	punct	.,analyzed
R8064	T12432	T12433	nmod	Coomassie,staining
R8065	T12433	T12435	nsubj	staining,verified
R8066	T12434	T12433	amod	blue,staining
R8067	T12436	T12437	amod	equal,loading
R8068	T12437	T12435	dobj	loading,verified
R8069	T12438	T12437	prep	of,loading
R8070	T12439	T12440	compound	GST,protein
R8071	T12440	T12438	pobj	protein,of
R8072	T12441	T12440	compound	fusion,protein
R8073	T12442	T12435	punct	.,verified
R8074	T12444	T12445	amod	Dried,gels
R8075	T12445	T12446	nsubjpass	gels,autoradiographed
R8076	T12447	T12446	auxpass	were,autoradiographed
R8077	T12448	T12446	punct	.,autoradiographed
R8078	T12469	T12470	amod	Phylogenetic,analysis
R8079	T12471	T12470	prep	of,analysis
R8080	T12472	T12473	det	the,members
R8081	T12473	T12471	pobj	members,of
R8082	T12474	T12473	compound	TACC,members
R8083	T12475	T12473	compound	family,members
R8084	T12476	T12470	prep	compared,analysis
R8085	T12477	T12476	prep	to,compared
R8086	T12478	T12479	amod	other,proteins
R8087	T12479	T12477	pobj	proteins,to
R8088	T12480	T12481	amod	coiled,coil
R8089	T12481	T12479	compound	coil,proteins
R8090	T12482	T12470	punct	.,analysis
R8091	T12484	T12485	det	The,tree
R8092	T12485	T12487	nsubjpass	tree,constructed
R8093	T12486	T12485	amod	phylogenetic,tree
R8094	T12488	T12487	auxpass	was,constructed
R8095	T12489	T12490	mark	as,described
R8096	T12490	T12487	advcl	described,constructed
R8097	T12491	T12490	prep	in,described
R8098	T12492	T12493	det	the,section
R8099	T12493	T12491	pobj	section,in
R8100	T12494	T12493	compound	Methods,section
R8101	T12495	T12487	punct	.,constructed
R8102	T12497	T12498	det	The,family
R8103	T12498	T12500	nsubj	family,defines
R8104	T12499	T12498	compound	TACC,family
R8105	T12501	T12502	det	a,subfamily
R8106	T12502	T12500	dobj	subfamily,defines
R8107	T12503	T12502	amod	separate,subfamily
R8108	T12504	T12502	prep	of,subfamily
R8109	T12505	T12506	amod	coiled,coil
R8110	T12506	T12507	npadvmod	coil,containing
R8111	T12507	T12508	amod	containing,proteins
R8112	T12508	T12504	pobj	proteins,of
R8113	T12509	T12502	punct	", ",subfamily
R8114	T12510	T12502	amod	distinct,subfamily
R8115	T12511	T12510	prep	from,distinct
R8116	T12512	T12513	amod	other,families
R8117	T12513	T12511	pobj	families,from
R8118	T12514	T12515	amod	coiled,coil
R8119	T12515	T12513	compound	coil,families
R8120	T12516	T12517	amod	such,as
R8121	T12517	T12513	prep	as,families
R8122	T12518	T12519	det	the,keratins
R8123	T12519	T12517	pobj	keratins,as
R8124	T12520	T12519	punct	", ",keratins
R8125	T12521	T12519	conj	RHAMM,keratins
R8126	T12522	T12521	cc	and,RHAMM
R8127	T12523	T12521	conj	tropomyosins,RHAMM
R8128	T12524	T12500	punct	.,defines
R8129	T12527	T12528	mark	that,form
R8130	T12528	T12526	ccomp	form,Note
R8131	T12529	T12530	det	the,proteins
R8132	T12530	T12528	nsubj	proteins,form
R8133	T12531	T12530	compound	RHAMM,proteins
R8134	T12532	T12533	det	a,branch
R8135	T12533	T12528	dobj	branch,form
R8136	T12534	T12533	amod	separate,branch
R8137	T12535	T12536	advmod	more,closely
R8138	T12536	T12537	advmod	closely,related
R8139	T12537	T12533	amod	related,branch
R8140	T12538	T12537	prep	to,related
R8141	T12539	T12540	det	the,tropomyosins
R8142	T12540	T12538	pobj	tropomyosins,to
R8143	T12541	T12540	cc	and,tropomyosins
R8144	T12542	T12543	npadvmod	kinesin,like
R8145	T12543	T12544	amod	like,proteins
R8146	T12544	T12540	conj	proteins,tropomyosins
R8147	T12545	T12544	punct	(,proteins
R8148	T12546	T12544	appos	KLP,proteins
R8149	T12547	T12537	punct	),related
R8150	T12548	T12537	punct	", ",related
R8151	T12549	T12537	prep	than,related
R8152	T12550	T12551	det	the,proteins
R8153	T12551	T12549	pobj	proteins,than
R8154	T12552	T12551	compound	TACC,proteins
R8155	T12553	T12526	punct	.,Note
R8159	T12611	T12612	amod	Linear,organization
R8160	T12613	T12612	prep	of,organization
R8161	T12614	T12615	compound	gene,clusters
R8162	T12615	T12613	pobj	clusters,of
R8163	T12616	T12612	acl	centering,organization
R8164	T12617	T12616	prep	upon,centering
R8165	T12618	T12619	det	the,loci
R8166	T12619	T12617	pobj	loci,upon
R8167	T12620	T12619	amod	chromosomal,loci
R8168	T12621	T12619	prep	of,loci
R8169	T12622	T12623	det	the,genes
R8170	T12623	T12621	pobj	genes,of
R8171	T12624	T12623	compound	FGFR,genes
R8172	T12625	T12619	prep	in,loci
R8173	T12626	T12625	pobj	humans,in
R8174	T12627	T12612	punct	.,organization
R8175	T12629	T12630	amod	Paralogous,genes
R8176	T12630	T12631	nsubjpass	genes,shown
R8177	T12632	T12630	amod	present,genes
R8178	T12633	T12632	prep	in,present
R8179	T12634	T12635	advmod	at,two
R8180	T12635	T12633	pobj	two,in
R8181	T12636	T12635	advmod	least,two
R8182	T12637	T12635	prep	of,two
R8183	T12638	T12639	det	the,loci
R8184	T12639	T12637	pobj	loci,of
R8185	T12640	T12639	nummod	four,loci
R8186	T12641	T12631	auxpass	are,shown
R8187	T12642	T12631	punct	", ",shown
R8188	T12643	T12631	prep	with,shown
R8189	T12644	T12645	det	the,exception
R8190	T12645	T12643	pobj	exception,with
R8191	T12646	T12645	prep	of,exception
R8192	T12647	T12648	det	the,region
R8193	T12648	T12646	pobj	region,of
R8194	T12649	T12648	prep	between,region
R8195	T12650	T12649	pobj	GPX3,between
R8196	T12651	T12650	cc	and,GPX3
R8197	T12652	T12650	conj	NKX2E,GPX3
R8198	T12653	T12650	prep	on,GPX3
R8199	T12654	T12653	pobj	chromosome,on
R8200	T12655	T12654	nummod	5,chromosome
R8201	T12656	T12648	punct	", ",region
R8202	T12657	T12658	dep	which,appears
R8203	T12658	T12648	relcl	appears,region
R8204	T12659	T12660	aux	to,represent
R8205	T12660	T12658	xcomp	represent,appears
R8206	T12661	T12662	det	a,series
R8207	T12662	T12660	dobj	series,represent
R8208	T12663	T12662	prep	of,series
R8209	T12664	T12665	amod	intervening,genes
R8210	T12665	T12663	pobj	genes,of
R8211	T12666	T12662	acl	inserted,series
R8212	T12667	T12666	prep	after,inserted
R8213	T12668	T12667	pobj	duplication,after
R8214	T12669	T12668	prep	of,duplication
R8215	T12670	T12671	det	the,clusters
R8216	T12671	T12669	pobj	clusters,of
R8217	T12672	T12673	nmod	4p16,5q32
R8218	T12673	T12671	nmod	5q32,clusters
R8219	T12674	T12673	punct	/,5q32
R8220	T12675	T12673	punct	-,5q32
R8221	T12676	T12673	nummod	35,5q32
R8222	T12677	T12648	punct	", ",region
R8223	T12678	T12648	cc	and,region
R8224	T12679	T12648	conj	genes,region
R8225	T12680	T12679	acl	mentioned,genes
R8226	T12681	T12680	prep	in,mentioned
R8227	T12682	T12681	pobj	Fig.,in
R8228	T12683	T12682	nummod	3,Fig.
R8229	T12684	T12631	punct	.,shown
R8230	T12686	T12687	amod	Corresponding,regions
R8231	T12687	T12691	nsubjpass	regions,indicated
R8232	T12688	T12687	amod	syntenic,regions
R8233	T12689	T12687	nmod	mouse,regions
R8234	T12690	T12687	amod	chromosomal,regions
R8235	T12692	T12693	punct	(,mm
R8236	T12693	T12687	parataxis	mm,regions
R8237	T12694	T12693	punct	*,mm
R8238	T12695	T12693	punct	),mm
R8239	T12696	T12691	auxpass	are,indicated
R8240	T12697	T12691	punct	.,indicated
R8241	T12699	T12700	compound	Takifugu,rubripes
R8242	T12700	T12701	compound	rubripes,scaffolds
R8243	T12701	T12702	nsubjpass	scaffolds,shown
R8244	T12703	T12702	auxpass	are,shown
R8245	T12704	T12705	punct	(,TR
R8246	T12705	T12702	parataxis	TR,shown
R8247	T12706	T12705	punct	*,TR
R8248	T12707	T12705	punct	),TR
R8249	T12708	T12709	dep	that,contain
R8250	T12709	T12702	ccomp	contain,shown
R8251	T12710	T12711	amod	more,one
R8252	T12711	T12713	nummod	one,gene
R8253	T12712	T12711	quantmod	than,one
R8254	T12713	T12709	dobj	gene,contain
R8255	T12714	T12713	amod	homologous,gene
R8256	T12715	T12713	prep	from,gene
R8257	T12716	T12717	det	these,clusters
R8258	T12717	T12715	pobj	clusters,from
R8259	T12718	T12702	punct	.,shown
R8260	T12720	T12721	amod	Further,details
R8261	T12721	T12722	nsubjpass	details,found
R8262	T12723	T12721	prep	on,details
R8263	T12724	T12725	det	the,location
R8264	T12725	T12723	pobj	location,on
R8265	T12726	T12725	prep	of,location
R8266	T12727	T12728	amod	paralogous,genes
R8267	T12728	T12726	pobj	genes,of
R8268	T12729	T12722	aux	can,found
R8269	T12730	T12722	auxpass	be,found
R8270	T12731	T12722	prep	in,found
R8271	T12732	T12733	punct	[,see
R8272	T12733	T12731	pcomp	see,in
R8273	T12734	T12735	amod	Additional,file
R8274	T12735	T12733	dobj	file,see
R8275	T12736	T12735	nummod	1,file
R8276	T12737	T12733	punct	],see
R8277	T12738	T12722	punct	.,found
R8282	T12815	T12814	prep	of,Formation
R8283	T12816	T12815	pobj	protoclusters,of
R8284	T12817	T12814	prep	in,Formation
R8285	T12818	T12819	compound	Takifugu,rubripes
R8286	T12819	T12817	pobj	rubripes,in
R8287	T12820	T12819	cc	and,rubripes
R8288	T12821	T12822	compound	Ciona,intestinalis
R8289	T12822	T12819	conj	intestinalis,rubripes
R8290	T12823	T12814	punct	: ,Formation
R8291	T12824	T12825	punct	(,A
R8292	T12825	T12827	meta	A,Structure
R8293	T12828	T12825	punct	),A
R8294	T12829	T12827	punct	: ,Structure
R8295	T12830	T12827	prep	of,Structure
R8296	T12831	T12832	det	the,scaffolds
R8297	T12832	T12830	pobj	scaffolds,of
R8298	T12833	T12832	amod	genomic,scaffolds
R8299	T12834	T12832	acl	containing,scaffolds
R8300	T12835	T12836	det	the,genes
R8301	T12836	T12834	dobj	genes,containing
R8302	T12837	T12838	nmod	Takifugu,rubripes
R8303	T12838	T12836	nmod	rubripes,genes
R8304	T12839	T12836	nmod	trTACC1A,genes
R8305	T12840	T12839	cc	and,trTACC1A
R8306	T12841	T12839	conj	trTACC1B,trTACC1A
R8307	T12842	T12827	punct	.,Structure
R8308	T12844	T12845	nsubj	Scaffold,contains
R8309	T12846	T12844	nummod	12,Scaffold
R8310	T12847	T12844	punct	", ",Scaffold
R8311	T12848	T12849	det	the,site
R8312	T12849	T12844	appos	site,Scaffold
R8313	T12850	T12849	prep	for,site
R8314	T12851	T12852	det	the,gene
R8315	T12852	T12850	pobj	gene,for
R8316	T12853	T12852	compound	trTACC1A,gene
R8317	T12854	T12845	dobj	genes,contains
R8318	T12855	T12854	acl	found,genes
R8319	T12856	T12855	prep	with,found
R8320	T12857	T12858	preconj	either,homologues
R8321	T12858	T12856	pobj	homologues,with
R8322	T12859	T12858	cc	or,homologues
R8323	T12860	T12858	conj	orthologues,homologues
R8324	T12861	T12855	prep	on,found
R8325	T12862	T12863	det	the,arm
R8326	T12863	T12861	pobj	arm,on
R8327	T12864	T12863	amod	distal,arm
R8328	T12865	T12863	amod	long,arm
R8329	T12866	T12863	prep	of,arm
R8330	T12867	T12868	amod	human,4p16
R8331	T12868	T12866	pobj	4p16,of
R8332	T12869	T12868	nmod	chromosome,4p16
R8333	T12870	T12868	nummod	10,4p16
R8334	T12871	T12868	cc	and,4p16
R8335	T12872	T12845	punct	.,contains
R8336	T12874	T12875	det	This,scaffold
R8337	T12875	T12876	nsubj	scaffold,has
R8338	T12877	T12876	punct	", ",has
R8339	T12878	T12876	advmod	therefore,has
R8340	T12879	T12876	punct	", ",has
R8341	T12880	T12876	dobj	some,has
R8342	T12881	T12880	prep	of,some
R8343	T12882	T12883	det	the,characteristics
R8344	T12883	T12881	pobj	characteristics,of
R8345	T12884	T12883	prep	of,characteristics
R8346	T12885	T12886	det	the,ancestor
R8347	T12886	T12884	pobj	ancestor,of
R8348	T12887	T12886	amod	predicted,ancestor
R8349	T12888	T12886	amod	immediate,ancestor
R8350	T12889	T12886	prep	of,ancestor
R8351	T12890	T12891	det	the,segment
R8352	T12891	T12889	pobj	segment,of
R8353	T12892	T12893	nmod	TACC1,TACC2
R8354	T12893	T12891	nmod	TACC2,segment
R8355	T12894	T12893	punct	/,TACC2
R8356	T12895	T12891	amod	chromosomal,segment
R8357	T12896	T12876	punct	.,has
R8358	T12898	T12899	nsubjpass	trTACC1B,found
R8359	T12900	T12899	auxpass	is,found
R8360	T12901	T12899	prep	on,found
R8361	T12902	T12901	pobj	scaffold,on
R8362	T12903	T12902	nummod	191,scaffold
R8363	T12904	T12902	punct	", ",scaffold
R8364	T12905	T12906	dep	which,contains
R8365	T12906	T12902	relcl	contains,scaffold
R8366	T12907	T12906	dobj	orthologues,contains
R8367	T12908	T12907	prep	of,orthologues
R8368	T12909	T12908	pobj	genes,of
R8369	T12910	T12909	acl	found,genes
R8370	T12911	T12910	prep	in,found
R8371	T12912	T12913	det	the,arm
R8372	T12913	T12911	pobj	arm,in
R8373	T12914	T12913	amod	proximal,arm
R8374	T12915	T12913	amod	short,arm
R8375	T12916	T12913	prep	of,arm
R8376	T12917	T12918	amod	human,chromosome
R8377	T12918	T12916	pobj	chromosome,of
R8378	T12919	T12918	nummod	8,chromosome
R8379	T12920	T12899	punct	.,found
R8380	T12922	T12923	punct	(,B
R8381	T12923	T12924	meta	B,clusters
R8382	T12925	T12923	punct	),B
R8383	T12926	T12924	punct	: ,clusters
R8384	T12927	T12928	compound	Ciona,intestinalis
R8385	T12928	T12924	compound	intestinalis,clusters
R8386	T12929	T12924	acl	containing,clusters
R8387	T12930	T12929	dobj	genes,containing
R8388	T12931	T12930	acl	found,genes
R8389	T12932	T12931	prep	in,found
R8390	T12933	T12934	amod	paralogous,segments
R8391	T12934	T12932	pobj	segments,in
R8392	T12935	T12931	prep	on,found
R8393	T12936	T12937	amod	human,4p16
R8394	T12937	T12935	pobj	4p16,on
R8395	T12938	T12937	nummod	8,4p16
R8396	T12939	T12937	punct	", ",4p16
R8397	T12940	T12937	punct	", ",4p16
R8398	T12941	T12937	conj	10q,4p16
R8399	T12942	T12941	cc	and,10q
R8400	T12943	T12941	conj	5q,10q
R8401	T12944	T12924	punct	.,clusters
R8402	T12994	T12995	amod	Genomic,structure
R8403	T12996	T12995	prep	of,structure
R8404	T12997	T12998	det	the,genes
R8405	T12998	T12996	pobj	genes,of
R8406	T12999	T12998	compound	TACC,genes
R8407	T13000	T12995	punct	.,structure
R8408	T13002	T13003	amod	Conserved,regions
R8409	T13003	T13004	nsubjpass	regions,shown
R8410	T13005	T13003	acl	known,regions
R8411	T13006	T13007	aux	to,bind
R8412	T13007	T13005	xcomp	bind,known
R8413	T13008	T13009	compound	protein,factors
R8414	T13009	T13007	dobj	factors,bind
R8415	T13010	T13007	prep	in,bind
R8416	T13011	T13012	det	all,proteins
R8417	T13012	T13010	pobj	proteins,in
R8418	T13013	T13012	amod	human,proteins
R8419	T13014	T13012	compound	TACC,proteins
R8420	T13015	T13004	auxpass	are,shown
R8421	T13016	T13004	punct	.,shown
R8422	T13018	T13019	det	The,repeat
R8423	T13019	T13021	nsubjpass	repeat,known
R8424	T13020	T13019	compound	SDP,repeat
R8425	T13022	T13019	prep	of,repeat
R8426	T13023	T13024	amod	human,TACC1
R8427	T13024	T13022	pobj	TACC1,of
R8428	T13025	T13024	punct	-,TACC1
R8429	T13026	T13024	nummod	3,TACC1
R8430	T13027	T13021	auxpass	is,known
R8431	T13028	T13029	aux	to,bind
R8432	T13029	T13021	xcomp	bind,known
R8433	T13030	T13029	dobj	GAS41,bind
R8434	T13031	T13032	punct	(,15
R8435	T13032	T13021	parataxis	15,known
R8436	T13033	T13032	punct	[,15
R8437	T13034	T13032	nummod	3,15
R8438	T13035	T13032	punct	",",15
R8439	T13036	T13032	punct	],15
R8440	T13037	T13032	cc	and,15
R8441	T13038	T13039	nsubj	data,shown
R8442	T13039	T13032	conj	shown,15
R8443	T13040	T13039	neg	not,shown
R8444	T13041	T13032	punct	),15
R8445	T13042	T13021	punct	.,known
R8446	T13044	T13045	det	The,domain
R8447	T13045	T13047	nsubj	domain,binds
R8448	T13046	T13045	compound	TACC,domain
R8449	T13048	T13049	compound	ch,TOG
R8450	T13049	T13047	dobj	TOG,binds
R8451	T13050	T13049	punct	-,TOG
R8452	T13051	T13049	cc	and,TOG
R8453	T13052	T13049	conj	members,TOG
R8454	T13053	T13052	prep	of,members
R8455	T13054	T13055	det	the,kinases
R8456	T13055	T13053	pobj	kinases,of
R8457	T13056	T13055	compound	Aurora,kinases
R8458	T13057	T13047	prep	in,binds
R8459	T13058	T13059	det	all,species
R8460	T13059	T13057	pobj	species,in
R8461	T13060	T13059	acl	examined,species
R8462	T13061	T13060	prep	to,examined
R8463	T13062	T13061	pobj	date,to
R8464	T13063	T13047	punct	.,binds
R8465	T13065	T13066	det	This,motif
R8466	T13066	T13067	nsubjpass	motif,encoded
R8467	T13068	T13067	auxpass	is,encoded
R8468	T13069	T13067	advmod	characteristically,encoded
R8469	T13070	T13067	agent	by,encoded
R8470	T13071	T13072	det	the,exons
R8471	T13072	T13070	pobj	exons,by
R8472	T13073	T13072	nummod	3,exons
R8473	T13074	T13073	punct	',3
R8474	T13075	T13072	prep	of,exons
R8475	T13076	T13077	det	the,genes
R8476	T13077	T13075	pobj	genes,of
R8477	T13078	T13077	compound	TACC,genes
R8478	T13079	T13067	punct	.,encoded
R8479	T13081	T13082	det	The,size
R8480	T13082	T13083	nsubjpass	size,shown
R8481	T13084	T13082	prep	of,size
R8482	T13085	T13086	det	the,isoform
R8483	T13086	T13084	pobj	isoform,of
R8484	T13087	T13086	amod	largest,isoform
R8485	T13088	T13086	prep	for,isoform
R8486	T13089	T13090	det	each,gene
R8487	T13090	T13088	pobj	gene,for
R8488	T13091	T13083	auxpass	is,shown
R8489	T13092	T13083	punct	.,shown
R8490	T13211	T13212	amod	Alternative,splicing
R8491	T13213	T13212	prep	of,splicing
R8492	T13214	T13215	det	the,gene
R8493	T13215	T13213	pobj	gene,of
R8494	T13216	T13215	amod	human,gene
R8495	T13217	T13215	compound	TACC1,gene
R8496	T13218	T13212	punct	.,splicing
R8497	T13220	T13221	punct	(,A
R8498	T13221	T13222	meta	A,identified
R8499	T13223	T13221	punct	),A
R8500	T13224	T13222	punct	: ,identified
R8501	T13225	T13226	nummod	Seven,variants
R8502	T13226	T13222	nsubjpass	variants,identified
R8503	T13227	T13226	compound	splice,variants
R8504	T13228	T13222	aux	have,identified
R8505	T13229	T13222	auxpass	been,identified
R8506	T13230	T13222	prep	for,identified
R8507	T13231	T13232	amod	human,TACC1
R8508	T13232	T13230	pobj	TACC1,for
R8509	T13233	T13234	punct	(,A
R8510	T13234	T13222	parataxis	A,identified
R8511	T13235	T13236	punct	-,F
R8512	T13236	T13234	prep	F,A
R8513	T13237	T13234	cc	and,A
R8514	T13238	T13234	conj	S,A
R8515	T13239	T13234	punct	),A
R8516	T13240	T13222	punct	.,identified
R8517	T13242	T13243	nsubj	We,identified
R8518	T13244	T13243	aux	have,identified
R8519	T13245	T13243	advmod	also,identified
R8520	T13246	T13247	amod	additional,variants
R8521	T13247	T13243	dobj	variants,identified
R8522	T13248	T13247	compound	splice,variants
R8523	T13249	T13250	punct	(,G
R8524	T13250	T13247	parataxis	G,variants
R8525	T13251	T13252	punct	-,I
R8526	T13252	T13250	prep	I,G
R8527	T13253	T13250	punct	),G
R8528	T13254	T13243	prep	from,identified
R8529	T13255	T13256	compound	database,analysis
R8530	T13256	T13254	pobj	analysis,from
R8531	T13257	T13256	cc	and,analysis
R8532	T13258	T13259	compound	rt,PCR
R8533	T13259	T13261	compound	PCR,analysis
R8534	T13260	T13259	punct	-,PCR
R8535	T13261	T13256	conj	analysis,analysis
R8536	T13262	T13261	prep	of,analysis
R8537	T13263	T13264	amod	human,brain
R8538	T13264	T13265	compound	brain,RNA
R8539	T13265	T13262	pobj	RNA,of
R8540	T13266	T13243	punct	.,identified
R8541	T13268	T13269	punct	(,B
R8542	T13269	T13270	meta	B,splicing
R8543	T13271	T13269	punct	),B
R8544	T13272	T13270	punct	: ,splicing
R8545	T13273	T13270	amod	Alternative,splicing
R8546	T13274	T13270	prep	of,splicing
R8547	T13275	T13274	pobj	TACC1,of
R8548	T13276	T13270	prep	in,splicing
R8549	T13277	T13278	det	the,brain
R8550	T13278	T13276	pobj	brain,in
R8551	T13279	T13278	amod	human,brain
R8552	T13280	T13270	punct	.,splicing
R8553	T13282	T13283	compound	rt,PCR
R8554	T13283	T13285	compound	PCR,analysis
R8555	T13284	T13283	punct	-,PCR
R8556	T13285	T13286	nsubj	analysis,confirms
R8557	T13287	T13286	dobj	splicing,confirms
R8558	T13288	T13287	prep	of,splicing
R8559	T13289	T13290	det	the,exon
R8560	T13290	T13288	pobj	exon,of
R8561	T13291	T13290	amod	untranslated,exon
R8562	T13292	T13290	nummod	1a,exon
R8563	T13293	T13287	prep	to,splicing
R8564	T13294	T13293	pobj	exon,to
R8565	T13295	T13294	nummod	1,exon
R8566	T13296	T13287	punct	", ",splicing
R8567	T13297	T13287	prep	with,splicing
R8568	T13298	T13297	pobj	retention,with
R8569	T13299	T13298	prep	of,retention
R8570	T13300	T13301	det	the,methionine
R8571	T13301	T13299	pobj	methionine,of
R8572	T13302	T13303	advmod	originally,defined
R8573	T13303	T13301	amod	defined,methionine
R8574	T13304	T13301	compound	start,methionine
R8575	T13305	T13306	punct	(,NP_006274
R8576	T13306	T13286	parataxis	NP_006274,confirms
R8577	T13307	T13306	nmod	GB,NP_006274
R8578	T13308	T13306	punct	:,NP_006274
R8579	T13309	T13306	punct	),NP_006274
R8580	T13310	T13311	punct	(,1
R8581	T13311	T13286	parataxis	1,confirms
R8582	T13312	T13313	compound	Variant,A
R8583	T13313	T13311	dep	A,1
R8584	T13314	T13313	punct	*,A
R8585	T13315	T13311	punct	", ",1
R8586	T13316	T13311	nmod	lanes,1
R8587	T13317	T13311	cc	and,1
R8588	T13318	T13311	conj	3,1
R8589	T13319	T13311	punct	),1
R8590	T13320	T13286	punct	.,confirms
R8591	T13322	T13323	nsubj	Exon,splices
R8592	T13324	T13322	nummod	1a,Exon
R8593	T13325	T13323	advmod	also,splices
R8594	T13326	T13323	prep	to,splices
R8595	T13327	T13326	pobj	exon,to
R8596	T13328	T13327	nummod	2,exon
R8597	T13329	T13323	punct	", ",splices
R8598	T13330	T13323	advcl	removing,splices
R8599	T13331	T13332	det	the,motif
R8600	T13332	T13330	dobj	motif,removing
R8601	T13333	T13334	compound	L,Sm7
R8602	T13334	T13332	compound	Sm7,motif
R8603	T13335	T13334	punct	-,Sm7
R8604	T13336	T13332	compound	binding,motif
R8605	T13337	T13338	punct	(,3
R8606	T13338	T13323	parataxis	3,splices
R8607	T13339	T13340	compound	variant,I
R8608	T13340	T13338	dep	I,3
R8609	T13341	T13338	punct	", ",3
R8610	T13342	T13338	nmod	lanes,3
R8611	T13343	T13338	punct	",",3
R8612	T13344	T13338	conj	12,3
R8613	T13345	T13344	cc	and,12
R8614	T13346	T13344	conj	13,12
R8615	T13347	T13338	punct	),3
R8616	T13348	T13323	punct	.,splices
R8617	T13350	T13351	nsubj	Variants,remove
R8618	T13352	T13353	dep	that,delete
R8619	T13353	T13350	relcl	delete,Variants
R8620	T13354	T13353	advmod	functionally,delete
R8621	T13355	T13356	nmod	exons,2
R8622	T13356	T13353	dobj	2,delete
R8623	T13357	T13356	cc	and,2
R8624	T13358	T13357	punct	/,and
R8625	T13359	T13357	cc	or,and
R8626	T13360	T13356	conj	3,2
R8627	T13361	T13350	punct	", ",Variants
R8628	T13362	T13363	amod	such,as
R8629	T13363	T13350	prep	as,Variants
R8630	T13364	T13365	compound	variant,C
R8631	T13365	T13363	pobj	C,as
R8632	T13366	T13367	punct	(,lane
R8633	T13367	T13365	parataxis	lane,C
R8634	T13368	T13367	nummod	15,lane
R8635	T13369	T13367	punct	),lane
R8636	T13370	T13351	advmod	also,remove
R8637	T13371	T13372	det	the,signals
R8638	T13372	T13351	dobj	signals,remove
R8639	T13373	T13372	amod	predicted,signals
R8640	T13374	T13375	amod	nuclear,localization
R8641	T13375	T13372	compound	localization,signals
R8642	T13376	T13372	punct	", ",signals
R8643	T13377	T13372	cc	and,signals
R8644	T13378	T13379	det	the,domains
R8645	T13379	T13372	conj	domains,signals
R8646	T13380	T13379	compound	binding,domains
R8647	T13381	T13379	prep	for,domains
R8648	T13382	T13381	pobj	GAS41,for
R8649	T13383	T13382	cc	and,GAS41
R8650	T13384	T13382	conj	PCTAIRE2BP,GAS41
R8651	T13385	T13351	punct	.,remove
R8652	T13387	T13388	det	These,variants
R8653	T13388	T13389	nsubj	variants,retain
R8654	T13390	T13389	aux	would,retain
R8655	T13391	T13392	det	the,domain
R8656	T13392	T13389	dobj	domain,retain
R8657	T13393	T13392	compound	TACC,domain
R8658	T13394	T13392	punct	", ",domain
R8659	T13395	T13392	cc	and,domain
R8660	T13396	T13397	advmod	therefore,potential
R8661	T13397	T13392	conj	potential,domain
R8662	T13398	T13397	det	the,potential
R8663	T13399	T13400	aux	to,bind
R8664	T13400	T13397	acl	bind,potential
R8665	T13401	T13400	prep	to,bind
R8666	T13402	T13403	compound	ch,TOG
R8667	T13403	T13401	pobj	TOG,to
R8668	T13404	T13403	punct	-,TOG
R8669	T13405	T13403	cc	and,TOG
R8670	T13406	T13407	compound	Aurora,A
R8671	T13407	T13408	compound	A,kinase
R8672	T13408	T13403	conj	kinase,TOG
R8673	T13409	T13400	prep	in,bind
R8674	T13410	T13411	det	the,centrosome
R8675	T13411	T13409	pobj	centrosome,in
R8676	T13412	T13389	punct	.,retain
R8677	T13414	T13415	dep	Lane,X1R
R8678	T13415	T13420	dep	X1R,ladder
R8679	T13416	T13414	nummod	1,Lane
R8680	T13417	T13415	punct	: ,X1R
R8681	T13418	T13415	compound	EF,X1R
R8682	T13419	T13415	punct	/,X1R
R8683	T13421	T13420	punct	", ",ladder
R8684	T13422	T13423	dep	Lane,BX647R
R8685	T13423	T13420	dep	BX647R,ladder
R8686	T13424	T13422	nummod	2,Lane
R8687	T13425	T13423	punct	: ,BX647R
R8688	T13426	T13423	compound	EF,BX647R
R8689	T13427	T13423	punct	/,BX647R
R8690	T13428	T13420	punct	", ",ladder
R8691	T13429	T13430	dep	Lane,6SPR
R8692	T13430	T13420	dep	6SPR,ladder
R8693	T13431	T13429	nummod	3,Lane
R8694	T13432	T13430	punct	: ,6SPR
R8695	T13433	T13430	compound	EF,6SPR
R8696	T13434	T13430	punct	/,6SPR
R8697	T13435	T13420	punct	", ",ladder
R8698	T13436	T13437	dep	Lane,1DR
R8699	T13437	T13420	dep	1DR,ladder
R8700	T13438	T13436	nummod	4,Lane
R8701	T13439	T13437	punct	: ,1DR
R8702	T13440	T13437	compound	EF,1DR
R8703	T13441	T13437	punct	/,1DR
R8704	T13442	T13420	punct	", ",ladder
R8705	T13443	T13444	dep	Lane,128R
R8706	T13444	T13420	dep	128R,ladder
R8707	T13445	T13443	nummod	5,Lane
R8708	T13446	T13444	punct	", ",128R
R8709	T13447	T13444	compound	EF,128R
R8710	T13448	T13444	punct	/,128R
R8711	T13449	T13420	punct	", ",ladder
R8712	T13450	T13451	dep	Lane,X1R
R8713	T13451	T13420	dep	X1R,ladder
R8714	T13452	T13450	nummod	6,Lane
R8715	T13453	T13451	compound	X3F,X1R
R8716	T13454	T13451	punct	/,X1R
R8717	T13455	T13420	punct	", ",ladder
R8718	T13456	T13457	dep	Lane,BX647R
R8719	T13457	T13420	dep	BX647R,ladder
R8720	T13458	T13456	nummod	7,Lane
R8721	T13459	T13457	punct	: ,BX647R
R8722	T13460	T13457	compound	X3F,BX647R
R8723	T13461	T13457	punct	/,BX647R
R8724	T13462	T13420	punct	", ",ladder
R8725	T13463	T13464	dep	Lane,6SPR
R8726	T13464	T13420	dep	6SPR,ladder
R8727	T13465	T13463	nummod	8,Lane
R8728	T13466	T13464	punct	: ,6SPR
R8729	T13467	T13464	compound	X3F,6SPR
R8730	T13468	T13464	punct	/,6SPR
R8731	T13469	T13420	punct	", ",ladder
R8732	T13470	T13471	dep	Lane,1DR
R8733	T13471	T13420	dep	1DR,ladder
R8734	T13472	T13470	nummod	9,Lane
R8735	T13473	T13471	punct	: ,1DR
R8736	T13474	T13471	compound	X3F,1DR
R8737	T13475	T13471	punct	/,1DR
R8738	T13476	T13420	punct	", ",ladder
R8739	T13477	T13478	dep	Lane,128R
R8740	T13478	T13420	dep	128R,ladder
R8741	T13479	T13477	nummod	10,Lane
R8742	T13480	T13478	punct	", ",128R
R8743	T13481	T13478	compound	X3F,128R
R8744	T13482	T13478	punct	/,128R
R8745	T13483	T13420	punct	", ",ladder
R8746	T13484	T13485	dep	Lane,X1R
R8747	T13485	T13420	dep	X1R,ladder
R8748	T13486	T13484	nummod	11,Lane
R8749	T13487	T13485	punct	: ,X1R
R8750	T13488	T13485	compound	1DF,X1R
R8751	T13489	T13485	punct	/,X1R
R8752	T13490	T13420	punct	", ",ladder
R8753	T13491	T13492	dep	Lane,BX647R
R8754	T13492	T13420	dep	BX647R,ladder
R8755	T13493	T13491	nummod	12,Lane
R8756	T13494	T13492	punct	: ,BX647R
R8757	T13495	T13492	compound	1DF,BX647R
R8758	T13496	T13492	punct	/,BX647R
R8759	T13497	T13420	punct	", ",ladder
R8760	T13498	T13499	dep	Lane,6SPR
R8761	T13499	T13420	dep	6SPR,ladder
R8762	T13500	T13498	nummod	13,Lane
R8763	T13501	T13499	punct	: ,6SPR
R8764	T13502	T13499	compound	1DF,6SPR
R8765	T13503	T13499	punct	/,6SPR
R8766	T13504	T13420	punct	", ",ladder
R8767	T13505	T13506	dep	Lane,1DR
R8768	T13506	T13420	dep	1DR,ladder
R8769	T13507	T13505	nummod	14,Lane
R8770	T13508	T13506	punct	: ,1DR
R8771	T13509	T13506	compound	1DF,1DR
R8772	T13510	T13506	punct	/,1DR
R8773	T13511	T13420	punct	", ",ladder
R8774	T13512	T13513	dep	Lane,128R
R8775	T13513	T13420	dep	128R,ladder
R8776	T13514	T13512	nummod	15,Lane
R8777	T13515	T13513	punct	: ,128R
R8778	T13516	T13513	compound	1DF,128R
R8779	T13517	T13513	punct	/,128R
R8780	T13518	T13420	punct	", ",ladder
R8781	T13519	T13420	dep	Lane,ladder
R8782	T13520	T13519	nummod	16,Lane
R8783	T13521	T13420	punct	: ,ladder
R8784	T13522	T13420	nmod	Biorad,ladder
R8785	T13523	T13524	nummod	1,kb+
R8786	T13524	T13525	compound	kb+,Size
R8787	T13525	T13420	compound	Size,ladder
R8788	T13526	T13420	punct	.,ladder
R8791	T13617	T13618	amod	Functional,evolution
R8792	T13619	T13618	prep	of,evolution
R8793	T13620	T13621	det	the,proteins
R8794	T13621	T13619	pobj	proteins,of
R8795	T13622	T13621	compound	TACC,proteins
R8796	T13623	T13618	acl	modeled,evolution
R8797	T13624	T13623	prep	in,modeled
R8798	T13625	T13626	compound	C.,elegans
R8799	T13626	T13624	pobj	elegans,in
R8800	T13627	T13626	cc	and,elegans
R8801	T13628	T13629	compound	D.,melanogaster
R8802	T13629	T13626	conj	melanogaster,elegans
R8803	T13630	T13618	punct	.,evolution
R8804	T13632	T13633	punct	(,A
R8805	T13633	T13634	meta	A,shows
R8806	T13635	T13633	punct	),A
R8807	T13636	T13633	punct	.,A
R8808	T13637	T13638	compound	C.,elegans
R8809	T13638	T13639	compound	elegans,map
R8810	T13639	T13634	nsubj	map,shows
R8811	T13640	T13639	compound	interaction,map
R8812	T13641	T13642	advmod	empirically,defined
R8813	T13642	T13643	amod	defined,interactions
R8814	T13643	T13634	dobj	interactions,shows
R8815	T13644	T13643	prep	of,interactions
R8816	T13645	T13644	pobj	ceTAC,of
R8817	T13646	T13643	punct	", ",interactions
R8818	T13647	T13643	cc	and,interactions
R8819	T13648	T13649	amod	extrapolated,interactions
R8820	T13649	T13643	conj	interactions,interactions
R8821	T13650	T13649	acl	defined,interactions
R8822	T13651	T13650	agent	by,defined
R8823	T13652	T13651	punct	[,by
R8824	T13653	T13651	pobj	28,by
R8825	T13654	T13651	punct	],by
R8826	T13655	T13634	punct	.,shows
R8827	T13657	T13658	punct	(,B
R8828	T13658	T13659	meta	B,binds
R8829	T13660	T13658	punct	),B
R8830	T13661	T13659	punct	: ,binds
R8831	T13662	T13659	advcl	Using,binds
R8832	T13663	T13664	det	the,database
R8833	T13664	T13662	dobj	database,Using
R8834	T13665	T13664	compound	BIND,database
R8835	T13666	T13667	punct	[,29
R8836	T13667	T13662	parataxis	29,Using
R8837	T13668	T13667	punct	],29
R8838	T13669	T13659	punct	", ",binds
R8839	T13670	T13659	nsubj	DTACC,binds
R8840	T13671	T13659	advmod	directly,binds
R8841	T13672	T13659	prep	to,binds
R8842	T13673	T13672	pobj	TBPH,to
R8843	T13674	T13673	cc	and,TBPH
R8844	T13675	T13673	conj	CG14540,TBPH
R8845	T13676	T13659	punct	", ",binds
R8846	T13677	T13659	cc	and,binds
R8847	T13678	T13659	conj	thus,binds
R8848	T13679	T13678	advmod	indirectly,thus
R8849	T13680	T13678	prep	to,thus
R8850	T13681	T13682	compound	chromatin,remodeling
R8851	T13682	T13683	compound	remodeling,complexes
R8852	T13683	T13680	pobj	complexes,to
R8853	T13684	T13683	punct	(,complexes
R8854	T13685	T13686	compound	SWI,SNF
R8855	T13686	T13683	appos	SNF,complexes
R8856	T13687	T13686	punct	/,SNF
R8857	T13688	T13686	cc	and,SNF
R8858	T13689	T13690	compound	histone,acetyltransferases
R8859	T13690	T13686	conj	acetyltransferases,SNF
R8860	T13691	T13683	punct	),complexes
R8861	T13692	T13683	punct	", ",complexes
R8862	T13693	T13694	compound	DNA,damage
R8863	T13694	T13695	compound	damage,repair
R8864	T13695	T13696	compound	repair,machinery
R8865	T13696	T13683	conj	machinery,complexes
R8866	T13697	T13696	punct	(,machinery
R8867	T13698	T13696	prep	via,machinery
R8868	T13699	T13698	pobj	RAD23,via
R8869	T13700	T13696	punct	),machinery
R8870	T13701	T13696	punct	", ",machinery
R8871	T13702	T13696	cc	and,machinery
R8872	T13703	T13704	nmod	RNA,splicing
R8873	T13704	T13705	nmod	splicing,machinery
R8874	T13705	T13696	conj	machinery,machinery
R8875	T13706	T13704	punct	", ",splicing
R8876	T13707	T13704	conj	transport,splicing
R8877	T13708	T13707	cc	and,transport
R8878	T13709	T13707	conj	translational,transport
R8879	T13710	T13659	punct	.,binds
R8880	T13712	T13713	punct	(,C
R8881	T13713	T13714	meta	C,suggests
R8882	T13715	T13713	punct	),C
R8883	T13716	T13714	punct	: ,suggests
R8884	T13717	T13718	amod	Predicted,interaction
R8885	T13718	T13719	compound	interaction,map
R8886	T13719	T13714	nsubj	map,suggests
R8887	T13720	T13719	prep	for,map
R8888	T13721	T13722	compound	vertebrate,TACCs
R8889	T13722	T13720	pobj	TACCs,for
R8890	T13723	T13719	punct	", ",map
R8891	T13724	T13719	prep	based,map
R8892	T13725	T13724	prep	upon,based
R8893	T13726	T13725	pobj	ceTAC,upon
R8894	T13727	T13714	punct	", ",suggests
R8895	T13728	T13729	det	an,interaction
R8896	T13729	T13714	dobj	interaction,suggests
R8897	T13730	T13729	amod	indirect,interaction
R8898	T13731	T13729	prep	with,interaction
R8899	T13732	T13733	det	the,receptor
R8900	T13733	T13731	pobj	receptor,with
R8901	T13734	T13733	amod	nuclear,receptor
R8902	T13735	T13733	compound	hormone,receptor
R8903	T13736	T13733	appos	RXRβ,receptor
R8904	T13737	T13714	punct	.,suggests
R8905	T13739	T13740	nsubj	It,is
R8906	T13741	T13740	advmod	also,is
R8907	T13742	T13740	prep	of,is
R8908	T13743	T13742	pobj	interest,of
R8909	T13744	T13745	mark	that,predicts
R8910	T13745	T13740	ccomp	predicts,is
R8911	T13746	T13745	nsubj	this,predicts
R8912	T13747	T13748	det	a,interaction
R8913	T13748	T13745	dobj	interaction,predicts
R8914	T13749	T13748	amod	functional,interaction
R8915	T13750	T13748	prep	with,interaction
R8916	T13751	T13752	det	the,family
R8917	T13752	T13750	pobj	family,with
R8918	T13753	T13752	compound	LDB,family
R8919	T13754	T13752	punct	", ",family
R8920	T13755	T13756	dep	members,found
R8921	T13756	T13752	relcl	found,family
R8922	T13757	T13755	prep	of,members
R8923	T13758	T13757	pobj	which,of
R8924	T13759	T13756	auxpass	are,found
R8925	T13760	T13756	advmod	also,found
R8926	T13761	T13756	prep	in,found
R8927	T13762	T13763	npadvmod	TACC,containing
R8928	T13763	T13764	amod	containing,segments
R8929	T13764	T13761	pobj	segments,in
R8930	T13765	T13764	amod	paralogous,segments
R8931	T13766	T13756	advcl	noted,found
R8932	T13767	T13766	prep	in,noted
R8933	T13768	T13769	nmod	Figs,3
R8934	T13769	T13767	pobj	3,in
R8935	T13770	T13769	nummod	2,3
R8936	T13771	T13769	punct	", ",3
R8937	T13772	T13769	cc	and,3
R8938	T13773	T13774	amod	Additional,file
R8939	T13774	T13769	conj	file,3
R8940	T13775	T13774	nummod	1,file
R8941	T13776	T13740	punct	.,is
R8942	T13778	T13779	punct	(,D
R8943	T13779	T13780	meta	D,map
R8944	T13781	T13779	punct	),D
R8945	T13782	T13780	punct	: ,map
R8946	T13783	T13780	amod	Predicted,map
R8947	T13784	T13780	compound	TACC,map
R8948	T13785	T13780	compound	interaction,map
R8949	T13786	T13780	prep	based,map
R8950	T13787	T13786	prep	upon,based
R8951	T13788	T13787	pobj	DTACC,upon
R8952	T13789	T13780	punct	.,map
R8953	T13791	T13792	punct	(,E
R8954	T13792	T13793	meta	E,interactions
R8955	T13794	T13792	punct	),E
R8956	T13795	T13793	punct	: ,interactions
R8957	T13796	T13793	compound	Vertebrate,interactions
R8958	T13797	T13793	compound	TACC,interactions
R8959	T13798	T13793	acl	identified,interactions
R8960	T13799	T13798	prep	to,identified
R8961	T13800	T13799	pobj	date,to
R8962	T13801	T13793	punct	.,interactions
R8963	T13803	T13804	nsubj	?,denotes
R8964	T13805	T13804	dobj	uncertainty,denotes
R8965	T13806	T13805	prep	over,uncertainty
R8966	T13807	T13808	det	the,identity
R8967	T13808	T13806	pobj	identity,over
R8968	T13809	T13808	prep	of,identity
R8969	T13810	T13811	det	a,homologue
R8970	T13811	T13809	pobj	homologue,of
R8971	T13812	T13811	amod	functional,homologue
R8972	T13813	T13811	compound	vertebrate,homologue
R8973	T13814	T13804	punct	.,denotes
R8974	T13816	T13817	prep	In,denotes
R8975	T13818	T13816	pobj	C,In
R8976	T13819	T13818	punct	", ",C
R8977	T13820	T13818	conj	D,C
R8978	T13821	T13820	cc	and,D
R8979	T13822	T13820	conj	E,D
R8980	T13823	T13817	punct	", ",denotes
R8981	T13824	T13825	punct	','
R8982	T13825	T13817	nsubj	',denotes
R8983	T13826	T13825	punct	*,'
R8984	T13827	T13828	nummod	one,members
R8985	T13828	T13817	dobj	members,denotes
R8986	T13829	T13827	cc	or,one
R8987	T13830	T13827	conj	more,one
R8988	T13831	T13828	prep	of,members
R8989	T13832	T13833	det	the,family
R8990	T13833	T13831	pobj	family,of
R8991	T13834	T13833	nmod	TACC,family
R8992	T13835	T13834	cc	or,TACC
R8993	T13836	T13837	compound	Aurora,kinase
R8994	T13837	T13834	conj	kinase,TACC
R8995	T13838	T13817	punct	.,denotes
R8999	T13879	T13878	pobj	RXRβ3,of
R9000	T13880	T13879	cc	and,RXRβ3
R9001	T13881	T13879	conj	TACC2s,RXRβ3
R9002	T13882	T13877	punct	.,interaction
R9003	T13884	T13885	amod	Top,panel
R9004	T13885	T13886	dep	panel,Autoradiograph
R9005	T13886	T13888	dep	Autoradiograph,input
R9006	T13887	T13886	punct	: ,Autoradiograph
R9007	T13889	T13886	prep	of,Autoradiograph
R9008	T13890	T13891	nummod	12,%
R9009	T13891	T13892	compound	%,SDS
R9010	T13892	T13893	compound	SDS,gel
R9011	T13893	T13889	pobj	gel,of
R9012	T13894	T13893	compound	polyacrylamide,gel
R9013	T13895	T13886	prep	with,Autoradiograph
R9014	T13896	T13897	advmod	in,vitro
R9015	T13897	T13898	advmod	vitro,translated
R9016	T13898	T13899	amod	translated,construct
R9017	T13899	T13895	pobj	construct,with
R9018	T13900	T13899	compound	RXRβ3,construct
R9019	T13901	T13899	acl	pulled,construct
R9020	T13902	T13901	prt	down,pulled
R9021	T13903	T13901	prep	with,pulled
R9022	T13904	T13905	compound	GST,TACC2
R9023	T13905	T13903	pobj	TACC2,with
R9024	T13906	T13905	punct	-,TACC2
R9025	T13907	T13908	punct	(,Lane
R9026	T13908	T13905	parataxis	Lane,TACC2
R9027	T13909	T13908	nummod	1,Lane
R9028	T13910	T13908	punct	),Lane
R9029	T13911	T13905	cc	or,TACC2
R9030	T13912	T13905	conj	GST,TACC2
R9031	T13913	T13914	punct	(,Lane
R9032	T13914	T13912	parataxis	Lane,GST
R9033	T13915	T13914	nummod	2,Lane
R9034	T13916	T13914	punct	),Lane
R9035	T13917	T13888	punct	;,input
R9036	T13918	T13888	dep	Lane,input
R9037	T13919	T13918	nummod	3,Lane
R9038	T13920	T13888	punct	: ,input
R9039	T13921	T13888	nummod	5,input
R9040	T13922	T13888	compound	%,input
R9041	T13923	T13888	prep	of,input
R9042	T13924	T13925	advmod	in,vitro
R9043	T13925	T13926	amod	vitro,protein
R9044	T13926	T13923	pobj	protein,of
R9045	T13927	T13926	amod	translated,protein
R9046	T13928	T13929	compound	RXR,β
R9047	T13929	T13926	compound	β,protein
R9048	T13930	T13929	punct	-,β
R9049	T13931	T13888	punct	.,input
R9050	T13933	T13934	amod	Bottom,panels
R9051	T13934	T13936	nsubj	panels,represent
R9052	T13935	T13934	nummod	two,panels
R9053	T13937	T13938	nmod	Coomassie,gels
R9054	T13938	T13936	dobj	gels,represent
R9055	T13939	T13940	amod	blue,stained
R9056	T13940	T13938	amod	stained,gels
R9057	T13941	T13938	prep	of,gels
R9058	T13942	T13943	amod	pull,experiment
R9059	T13943	T13941	pobj	experiment,of
R9060	T13944	T13942	prt	down,pull
R9061	T13945	T13943	acl	showing,experiment
R9062	T13946	T13945	dobj	loading,showing
R9063	T13947	T13946	prep	of,loading
R9064	T13948	T13949	compound	GST,TACC2
R9065	T13949	T13947	pobj	TACC2,of
R9066	T13950	T13949	punct	-,TACC2
R9067	T13951	T13949	cc	and,TACC2
R9068	T13952	T13949	conj	GST,TACC2
R9069	T13953	T13936	punct	.,represent
R2	T174	T177	compound	function,evolution
R3	T176	T174	punct	-,function
R6	T180	T178	pobj	genes,of
R7	T181	T180	amod	Transforming,genes
R10	T184	T180	compound	coil,genes
R21	T200	T198	pobj	families,of
R22	T201	T200	compound	gene,families
R28	T207	T205	pcomp	relate,into
R29	T208	T209	det	the,evolution
R30	T209	T207	nsubj	evolution,relate
R31	T210	T209	prep	of,evolution
R32	T211	T212	compound	gene,structure
R33	T212	T210	pobj	structure,of
R34	T213	T207	aux	can,relate
R42	T223	T221	pobj	family,of
R43	T224	T225	advmod	evolutionarily,conserved
R44	T225	T223	amod	conserved,family
R45	T226	T227	amod	transforming,coil
R46	T227	T223	nmod	coil,family
R47	T228	T227	amod	acidic,coil
R48	T229	T227	amod	coiled,coil
R49	T230	T227	punct	(,coil
R50	T231	T227	appos	TACC,coil
R51	T232	T223	punct	),family
R52	T233	T223	compound	gene,family
R74	T257	T244	xcomp	determined,have
R75	T258	T257	aux	to,determined
R76	T259	T257	auxpass	be,determined
R81	T268	T265	dobj	analysis,performed
R82	T269	T268	amod	extensive,analysis
R83	T270	T268	compound	database,analysis
R87	T274	T272	dobj	sequences,determine
R88	T275	T274	amod	genomic,sequences
R89	T276	T275	cc	and,genomic
R90	T277	T275	conj	cDNA,genomic
R103	T292	T289	dobj	relationship,determined
R104	T293	T292	amod	phylogenetic,relationship
R107	T296	T294	pobj	proteins,of
R108	T297	T296	compound	TACC,proteins
R111	T300	T298	pobj	proteins,to
R112	T301	T302	amod	coiled,coil
R113	T302	T300	compound	coil,proteins
R122	T311	T309	pobj	TACC4,of
R123	T312	T311	compound	rabbit,TACC4
R135	T324	T322	pobj	family,as
R136	T325	T324	amod	distinct,family
R152	T343	T341	pobj	databases,to
R153	T344	T343	compound	interaction,databases
R164	T355	T352	dobj	interactions,identify
R165	T356	T355	compound	TACC,interactions
R185	T378	T376	pobj	receptor,to
R186	T379	T378	amod	nuclear,receptor
R187	T380	T378	compound	hormone,receptor
R195	T392	T388	ccomp	played,suggest
R196	T393	T394	det	the,protein
R197	T394	T392	nsubj	protein,played
R198	T395	T394	amod	ancestral,protein
R199	T396	T394	compound	TACC,protein
R204	T401	T403	amod	mitotic,dynamics
R205	T402	T401	punct	/,mitotic
R206	T403	T399	pobj	dynamics,in
R207	T404	T403	compound	spindle,dynamics
R228	T427	T425	pobj	proteins,with
R229	T428	T427	compound	bridging,proteins
R237	T438	T432	nsubj	proteins,acquired
R238	T439	T438	compound	TACC,proteins
R244	T445	T443	acl	interact,ability
R245	T446	T445	advmod	directly,interact
R255	T456	T454	pobj	proteins,as
R256	T457	T456	compound	LSm,proteins
R259	T460	T456	conj	receptors,proteins
R260	T461	T460	compound	hormone,receptors
R271	T474	T472	ccomp	evolved,suggests
R272	T475	T476	det	the,function
R273	T476	T474	nsubj	function,evolved
R274	T477	T476	prep	of,function
R275	T478	T479	det	the,proteins
R277	T480	T479	compound	TACC,proteins
R278	T481	T474	aux	may,evolved
R279	T482	T474	aux	have,evolved
R283	T486	T484	dobj	functions,performing
R284	T487	T485	cc	or,assembly
R285	T488	T485	conj	coordination,assembly
R292	T495	T493	dobj	role,include
R293	T496	T497	advmod	more,intimate
R294	T497	T495	amod	intimate,role
R297	T500	T498	pobj	evolution,in
R298	T501	T500	amod	functional,evolution
R304	T507	T504	appos	complexes,remodeling
R305	T508	T506	cc	and,transcriptional
R306	T509	T506	conj	posttranscriptional,transcriptional
R316	T703	T704	det	The,evolution
R317	T704	T705	nsubjpass	evolution,associated
R318	T706	T704	prep	of,evolution
R319	T707	T708	amod	complex,organisms
R320	T708	T706	pobj	organisms,of
R321	T709	T705	aux	has,associated
R322	T710	T705	auxpass	been,associated
R323	T711	T705	prep	with,associated
R324	T712	T713	det	the,generation
R325	T713	T711	pobj	generation,with
R326	T714	T713	prep	of,generation
R327	T715	T716	compound	gene,families
R328	T716	T714	pobj	families,of
R329	T717	T705	prep	by,associated
R330	T718	T719	det	the,duplication
R331	T719	T717	pobj	duplication,by
R332	T720	T719	amod	continual,duplication
R333	T721	T719	prep	of,duplication
R334	T722	T723	det	an,set
R335	T723	T721	pobj	set,of
R336	T724	T723	amod	initial,set
R337	T725	T726	advmod	relatively,small
R338	T726	T723	amod	small,set
R339	T727	T723	prep	of,set
R340	T728	T729	amod	ancestral,genes
R341	T729	T727	pobj	genes,of
R342	T730	T705	punct	.,associated
R343	T732	T733	prep	Through,evolved
R344	T734	T735	det	this,process
R345	T735	T732	pobj	process,Through
R346	T736	T735	punct	", ",process
R347	T737	T735	acl	followed,process
R348	T738	T737	agent	by,followed
R349	T739	T740	amod	subsequent,mutation
R350	T740	T738	pobj	mutation,by
R351	T741	T740	punct	", ",mutation
R352	T742	T740	conj	reduplication,mutation
R353	T743	T742	cc	and,reduplication
R354	T744	T745	compound	exon,shuffling
R355	T745	T742	conj	shuffling,reduplication
R356	T746	T740	prep	between,mutation
R357	T747	T748	compound	gene,families
R358	T748	T746	pobj	families,between
R359	T749	T733	punct	", ",evolved
R360	T750	T733	nsubj	genes,evolved
R361	T751	T733	aux	have,evolved
R362	T752	T753	preconj	both,discrete
R363	T753	T754	amod	discrete,functions
R364	T754	T733	dobj	functions,evolved
R365	T755	T753	punct	", ",discrete
R366	T756	T753	cc	and,discrete
R367	T757	T758	advmod	partially,redundant
R368	T758	T753	conj	redundant,discrete
R369	T759	T754	prep	with,functions
R370	T760	T761	poss	their,members
R371	T761	T759	pobj	members,with
R372	T762	T761	amod	related,members
R373	T763	T761	compound	family,members
R374	T764	T733	punct	.,evolved
R375	T766	T767	prep	With,are
R376	T768	T769	det	the,completion
R377	T769	T766	pobj	completion,With
R378	T770	T769	prep	of,completion
R379	T771	T772	det	the,projects
R380	T772	T770	pobj	projects,of
R381	T773	T774	compound	genome,sequencing
R382	T774	T772	compound	sequencing,projects
R383	T775	T772	prep	of,projects
R384	T776	T775	pobj	human,of
R385	T777	T776	punct	", ",human
R386	T778	T776	conj	mouse,human
R387	T779	T778	punct	", ",mouse
R388	T780	T778	conj	rat,mouse
R389	T781	T780	punct	", ",rat
R390	T782	T783	compound	fruit,fly
R391	T783	T780	conj	fly,rat
R392	T784	T783	cc	and,fly
R393	T785	T783	conj	nematodes,fly
R394	T786	T767	punct	", ",are
R395	T787	T767	nsubj	we,are
R396	T788	T767	advmod	now,are
R397	T789	T767	prep	in,are
R398	T790	T791	det	a,position
R399	T791	T789	pobj	position,in
R400	T792	T793	aux	to,ask
R401	T793	T791	acl	ask,position
R402	T794	T795	amod	fundamental,questions
R403	T795	T793	dobj	questions,ask
R404	T796	T793	prep	in,ask
R405	T797	T796	pobj	regard,in
R406	T798	T797	prep	to,regard
R407	T799	T800	advmod	how,interact
R408	T800	T798	pcomp	interact,to
R409	T801	T800	nsubj	genes,interact
R410	T802	T800	prep	in,interact
R411	T803	T804	det	the,context
R412	T804	T802	pobj	context,in
R413	T805	T804	prep	of,context
R414	T806	T807	det	the,organism
R415	T807	T805	pobj	organism,of
R416	T808	T807	amod	whole,organism
R417	T809	T767	punct	.,are
R418	T811	T812	advmod	Thus,is
R419	T813	T812	punct	", ",is
R420	T814	T812	prep	with,is
R421	T815	T816	det	the,application
R422	T816	T814	pobj	application,with
R423	T817	T816	amod	appropriate,application
R424	T818	T816	prep	of,application
R425	T819	T818	pobj	bioinformatics,of
R426	T820	T812	punct	", ",is
R427	T821	T812	nsubj	it,is
R428	T822	T812	advmod	now,is
R429	T823	T812	acomp	possible,is
R430	T824	T825	aux	to,trace
R431	T825	T812	xcomp	trace,is
R432	T826	T827	det	the,lineage
R433	T827	T825	dobj	lineage,trace
R434	T828	T827	prep	of,lineage
R435	T829	T830	amod	particular,genes
R436	T830	T828	pobj	genes,of
R437	T831	T830	cc	and,genes
R438	T832	T833	compound	gene,families
R439	T833	T830	conj	families,genes
R440	T834	T825	punct	", ",trace
R441	T835	T825	prep	with,trace
R442	T836	T837	amod	related,families
R443	T837	T835	pobj	families,with
R444	T838	T837	compound	gene,families
R445	T839	T837	prep	in,families
R446	T840	T841	amod	other,organisms
R447	T841	T839	pobj	organisms,in
R448	T842	T812	punct	.,is
R449	T844	T845	advmod	Furthermore,extended
R450	T846	T845	punct	", ",extended
R451	T847	T845	prep	with,extended
R452	T848	T849	det	the,amount
R453	T849	T851	nsubj	amount,becoming
R454	T850	T849	amod	growing,amount
R455	T851	T847	pcomp	becoming,with
R456	T852	T849	prep	of,amount
R457	T853	T854	amod	large,scale
R458	T854	T856	nmod	scale,data
R459	T855	T854	punct	-,scale
R460	T856	T852	pobj	data,of
R461	T857	T856	amod	proteomic,data
R462	T858	T857	cc	and,proteomic
R463	T859	T857	conj	genomic,proteomic
R464	T860	T861	advmod	publicly,available
R465	T861	T851	acomp	available,becoming
R466	T862	T845	punct	", ",extended
R467	T863	T864	det	this,analysis
R468	T864	T845	nsubjpass	analysis,extended
R469	T865	T845	aux	can,extended
R470	T866	T845	advmod	now,extended
R471	T867	T845	auxpass	be,extended
R472	T868	T869	aux	to,reveal
R473	T869	T845	advcl	reveal,extended
R474	T870	T871	det	the,interplay
R475	T871	T869	dobj	interplay,reveal
R476	T872	T871	amod	complex,interplay
R477	T873	T871	prep	between,interplay
R478	T874	T873	pobj	evolution,between
R479	T875	T874	prep	of,evolution
R480	T876	T877	compound	gene,structure
R481	T877	T875	pobj	structure,of
R482	T878	T874	cc	and,evolution
R483	T879	T880	compound	protein,function
R484	T880	T874	conj	function,evolution
R485	T881	T845	punct	.,extended
R486	T883	T884	det	The,gene
R488	T885	T884	amod	first,gene
R489	T886	T884	nmod	Transforming,gene
R490	T887	T884	amod	acidic,gene
R491	T888	T889	amod	coiled,coil
R492	T889	T884	compound	coil,gene
R493	T891	T884	punct	", ",gene
R494	T892	T884	appos	TACC1,gene
R495	T893	T890	punct	", ",identified
R496	T894	T890	auxpass	was,identified
R497	T895	T890	prep	during,identified
R498	T896	T897	det	the,development
R499	T897	T895	pobj	development,during
R500	T898	T897	prep	of,development
R501	T899	T900	det	an,map
R502	T900	T898	pobj	map,of
R503	T901	T900	compound	expression,map
R504	T902	T900	prep	of,map
R505	T903	T904	det	the,arm
R506	T904	T902	pobj	arm,of
R507	T905	T904	amod	proximal,arm
R508	T906	T904	amod	short,arm
R509	T907	T904	prep	of,arm
R510	T908	T909	amod	human,chromosome
R511	T909	T907	pobj	chromosome,of
R512	T910	T909	nummod	8,chromosome
R513	T911	T912	punct	[,1
R514	T912	T890	parataxis	1,identified
R515	T913	T912	punct	],1
R516	T914	T890	punct	.,identified
R517	T916	T917	nummod	Two,members
R518	T917	T921	nsubjpass	members,identified
R519	T918	T917	amod	additional,members
R520	T919	T917	compound	TACC,members
R521	T920	T917	compound	family,members
R522	T922	T921	auxpass	were,identified
R523	T923	T921	advmod	subsequently,identified
R524	T924	T921	cc	and,identified
R525	T925	T921	conj	mapped,identified
R526	T926	T925	prep	to,mapped
R527	T927	T928	amod	paralogous,regions
R528	T928	T926	pobj	regions,to
R529	T929	T928	amod	chromosomal,regions
R530	T930	T928	prep	on,regions
R531	T931	T932	amod	human,4p16
R532	T932	T930	pobj	4p16,on
R533	T933	T932	compound	chromosomes,4p16
R534	T934	T932	cc	and,4p16
R535	T935	T932	conj	10q26,4p16
R536	T936	T932	punct	", ",4p16
R537	T937	T938	advmod	physically,close
R538	T938	T932	amod	close,4p16
R539	T939	T938	prep	to,close
R540	T940	T939	pobj	members,to
R541	T941	T940	prep	of,members
R542	T942	T943	det	the,family
R543	T943	T941	pobj	family,of
R544	T944	T943	compound	FGFR,family
R545	T945	T943	compound	gene,family
R546	T946	T947	punct	[,1
R547	T947	T925	parataxis	1,mapped
R548	T948	T949	punct	-,3
R549	T949	T947	prep	3,1
R550	T950	T947	punct	],1
R551	T951	T921	punct	.,identified
R552	T953	T954	det	This,data
R553	T954	T956	nsubj	data,led
R554	T955	T954	compound	mapping,data
R555	T957	T954	punct	", ",data
R556	T958	T959	advmod	together,with
R557	T959	T954	prep	with,data
R558	T960	T959	pobj	identification,with
R559	T961	T960	prep	of,identification
R560	T962	T963	det	a,gene
R561	T963	T961	pobj	gene,of
R562	T964	T963	amod	single,gene
R563	T965	T963	compound	TACC,gene
R564	T966	T960	prep	in,identification
R565	T967	T968	det	the,elegans
R566	T968	T966	pobj	elegans,in
R567	T969	T968	compound	protostomes,elegans
R568	T970	T968	compound	Caenorhabitis,elegans
R569	T971	T968	punct	", ",elegans
R570	T972	T968	cc	and,elegans
R571	T973	T974	compound	Drosophila,melanogaster
R572	T974	T968	conj	melanogaster,elegans
R573	T975	T976	punct	[,4
R574	T976	T954	parataxis	4,data
R575	T977	T978	punct	-,6
R576	T978	T976	prep	6,4
R577	T979	T976	punct	],4
R578	T980	T956	punct	", ",led
R579	T981	T956	prep	to,led
R580	T982	T983	det	the,speculation
R581	T983	T981	pobj	speculation,to
R582	T984	T985	mark	that,located
R583	T985	T983	acl	located,speculation
R584	T986	T987	det	the,genes
R585	T987	T985	nsubjpass	genes,located
R586	T988	T987	amod	ancestral,genes
R587	T989	T987	nmod	FGFR,genes
R588	T990	T989	cc	and,FGFR
R589	T991	T989	conj	TACC,FGFR
R590	T992	T985	auxpass	were,located
R591	T993	T994	advmod	physically,close
R592	T994	T985	advmod	close,located
R593	T995	T994	prep	to,close
R594	T996	T997	det	each,other
R595	T997	T995	pobj	other,to
R596	T998	T956	punct	.,led
R597	T1000	T1001	advmod	Thus,given
R598	T1002	T1001	punct	", ",given
R599	T1003	T1001	prep	during,given
R600	T1004	T1005	det	the,evolution
R601	T1005	T1003	pobj	evolution,during
R602	T1006	T1005	prep	of,evolution
R603	T1007	T1006	pobj	vertebrates,of
R604	T1008	T1001	punct	", ",given
R605	T1009	T1010	amod	subsequent,duplications
R606	T1010	T1001	nsubj	duplications,given
R607	T1011	T1010	amod	successive,duplications
R608	T1012	T1010	prep	of,duplications
R609	T1013	T1014	det	the,cluster
R610	T1014	T1012	pobj	cluster,of
R611	T1015	T1014	amod	ancestral,cluster
R612	T1016	T1014	compound	gene,cluster
R613	T1017	T1001	aux	have,given
R614	T1018	T1001	dobj	rise,given
R615	T1019	T1001	prep	to,given
R616	T1020	T1021	nummod	three,members
R617	T1021	T1019	pobj	members,to
R618	T1022	T1021	compound	TACC,members
R619	T1023	T1021	compound	family,members
R620	T1024	T1021	acl	located,members
R621	T1025	T1024	advmod	close,located
R622	T1026	T1025	prep	to,close
R623	T1027	T1028	compound	FGFR,genes
R624	T1028	T1026	pobj	genes,to
R625	T1029	T1024	prep	in,located
R626	T1030	T1029	pobj	humans,in
R627	T1031	T1001	punct	.,given
R628	T1033	T1034	prep	In,is
R629	T1035	T1033	pobj	accordance,In
R630	T1036	T1035	prep	with,accordance
R631	T1037	T1038	det	the,quadruplication
R632	T1038	T1036	pobj	quadruplication,with
R633	T1039	T1038	amod	proposed,quadruplication
R634	T1040	T1038	prep	of,quadruplication
R635	T1041	T1042	det	the,genome
R636	T1042	T1040	pobj	genome,of
R637	T1043	T1042	compound	vertebrate,genome
R638	T1044	T1038	prep	during,quadruplication
R639	T1045	T1044	pobj	evolution,during
R640	T1046	T1034	punct	", ",is
R641	T1047	T1034	expl	there,is
R642	T1048	T1049	det	a,member
R643	T1049	T1034	attr	member,is
R644	T1050	T1049	amod	fourth,member
R645	T1051	T1049	compound	FGFR,member
R646	T1052	T1049	compound	family,member
R647	T1053	T1034	prep	in,is
R648	T1054	T1053	pobj	vertebrates,in
R649	T1055	T1034	punct	", ",is
R650	T1056	T1034	advcl	raising,is
R651	T1057	T1058	det	the,question
R652	T1058	T1056	dobj	question,raising
R653	T1059	T1058	prep	of,question
R654	T1060	T1061	mark	whether,associated
R656	T1062	T1063	det	a,gene
R657	T1063	T1061	nsubjpass	gene,associated
R658	T1064	T1063	amod	fourth,gene
R659	T1065	T1063	compound	TACC,gene
R660	T1066	T1061	auxpass	is,associated
R661	T1067	T1061	prep	with,associated
R662	T1068	T1067	pobj	FGFR4,with
R663	T1069	T1061	prep	in,associated
R664	T1070	T1071	compound	vertebrate,genomes
R665	T1071	T1069	pobj	genomes,in
R666	T1072	T1034	punct	.,is
R667	T1074	T1075	prep	To,one
R668	T1076	T1074	pobj	date,To
R669	T1077	T1075	punct	", ",one
R670	T1078	T1079	advmod	only,genes
R671	T1079	T1083	nsubjpass	genes,cloned
R672	T1080	T1079	nummod	three,genes
R673	T1081	T1079	amod	active,genes
R674	T1082	T1079	compound	TACC,genes
R675	T1083	T1075	ccomp	cloned,one
R676	T1084	T1083	aux	have,cloned
R677	T1085	T1083	auxpass	been,cloned
R678	T1086	T1083	prep	in,cloned
R679	T1087	T1086	pobj	humans,in
R680	T1088	T1089	punct	[,1
R681	T1089	T1083	parataxis	1,cloned
R682	T1090	T1091	punct	-,3
R683	T1091	T1089	prep	3,1
R684	T1092	T1089	punct	],1
R685	T1093	T1075	punct	", ",one
R686	T1094	T1075	prep	in,one
R687	T1095	T1094	pobj	each,in
R688	T1096	T1095	prep	of,each
R689	T1097	T1096	pobj	mouse,of
R690	T1098	T1099	punct	[,7
R691	T1099	T1097	parataxis	7,mouse
R692	T1100	T1099	punct	],7
R693	T1101	T1097	punct	", ",mouse
R694	T1102	T1103	compound	Xenopus,laevis
R695	T1103	T1097	conj	laevis,mouse
R696	T1104	T1105	punct	[,8
R697	T1105	T1103	parataxis	8,laevis
R698	T1106	T1105	punct	],8
R699	T1107	T1103	punct	", ",laevis
R700	T1108	T1109	compound	D.,melanogaster
R701	T1109	T1103	conj	melanogaster,laevis
R702	T1110	T1111	punct	[,4
R703	T1111	T1109	parataxis	4,melanogaster
R704	T1112	T1111	punct	],4
R705	T1113	T1109	punct	", ",melanogaster
R706	T1114	T1109	cc	and,melanogaster
R707	T1115	T1116	compound	C.,elegans
R708	T1116	T1109	conj	elegans,melanogaster
R709	T1117	T1118	punct	[,6
R710	T1118	T1116	parataxis	6,elegans
R711	T1119	T1118	nummod	5,6
R712	T1120	T1118	punct	",",6
R713	T1121	T1118	punct	],6
R714	T1122	T1075	punct	.,one
R715	T1124	T1125	mark	Although,proposed
R716	T1125	T1148	advcl	proposed,is
R717	T1126	T1127	nummod	two,members
R718	T1127	T1125	nsubjpass	members,proposed
R719	T1128	T1127	amod	additional,members
R720	T1129	T1127	amod	new,members
R721	T1130	T1127	compound	candidate,members
R722	T1131	T1127	compound	TACC,members
R723	T1132	T1127	compound	family,members
R724	T1133	T1127	punct	", ",members
R725	T1134	T1135	compound	Oryctolagus,TACC4
R726	T1135	T1127	appos	TACC4,members
R727	T1136	T1135	compound	cuniculus,TACC4
R728	T1137	T1138	punct	[,9
R729	T1138	T1135	parataxis	9,TACC4
R730	T1139	T1138	punct	],9
R731	T1140	T1135	cc	and,TACC4
R732	T1141	T1142	amod	human,RHAMM
R733	T1142	T1135	conj	RHAMM,TACC4
R734	T1143	T1144	punct	[,10
R735	T1144	T1142	parataxis	10,RHAMM
R736	T1145	T1144	punct	],10
R737	T1146	T1125	aux	have,proposed
R738	T1147	T1125	auxpass	been,proposed
R739	T1149	T1148	punct	", ",is
R740	T1150	T1151	poss	their,identity
R741	T1151	T1148	nsubj	identity,is
R742	T1152	T1151	amod	true,identity
R743	T1153	T1151	cc	and,identity
R744	T1154	T1151	conj	placement,identity
R745	T1155	T1151	prep	in,identity
R746	T1156	T1157	det	the,evolution
R747	T1157	T1155	pobj	evolution,in
R748	T1158	T1157	prep	of,evolution
R749	T1159	T1160	det	the,family
R750	T1160	T1158	pobj	family,of
R751	T1161	T1160	compound	TACC,family
R752	T1162	T1148	prep	under,is
R753	T1163	T1162	pobj	debate,under
R754	T1164	T1148	punct	.,is
R755	T1166	T1167	advmod	Thus,resolve
R756	T1168	T1167	punct	", ",resolve
R757	T1169	T1170	det	the,identification
R758	T1170	T1167	nsubj	identification,resolve
R759	T1171	T1170	cc	and,identification
R760	T1172	T1173	amod	functional,characterization
R761	T1173	T1170	conj	characterization,identification
R762	T1174	T1170	prep	of,identification
R763	T1175	T1176	amod	new,members
R764	T1176	T1174	pobj	members,of
R765	T1177	T1176	prep	of,members
R766	T1178	T1179	det	the,family
R767	T1179	T1177	pobj	family,of
R768	T1180	T1179	compound	TACC,family
R769	T1181	T1170	prep	in,identification
R770	T1182	T1183	amod	other,organisms
R771	T1183	T1181	pobj	organisms,in
R772	T1184	T1170	punct	", ",identification
R773	T1185	T1186	advmod	alternatively,spliced
R774	T1186	T1187	amod	spliced,isoforms
R775	T1187	T1170	conj	isoforms,identification
R776	T1188	T1187	prep	of,isoforms
R777	T1189	T1190	det	each,TACC
R778	T1190	T1188	pobj	TACC,of
R779	T1191	T1187	cc	and,isoforms
R780	T1192	T1187	conj	comparison,isoforms
R781	T1193	T1192	prep	of,comparison
R782	T1194	T1195	det	the,relationship
R783	T1195	T1193	pobj	relationship,of
R784	T1196	T1195	amod	phylogenetic,relationship
R785	T1197	T1195	prep	of,relationship
R786	T1198	T1199	det	these,genes
R787	T1199	T1197	pobj	genes,of
R788	T1200	T1195	amod	relative,relationship
R789	T1201	T1200	prep	to,relative
R790	T1202	T1203	amod	other,members
R791	T1203	T1201	pobj	members,to
R792	T1204	T1203	prep	of,members
R793	T1205	T1206	det	the,superfamily
R794	T1206	T1204	pobj	superfamily,of
R795	T1207	T1208	amod	coiled,coil
R796	T1208	T1206	compound	coil,superfamily
R797	T1209	T1167	aux	will,resolve
R798	T1210	T1211	det	this,issue
R799	T1211	T1167	dobj	issue,resolve
R800	T1212	T1167	cc	and,resolve
R801	T1213	T1167	conj	provide,resolve
R802	T1214	T1213	dobj	clues,provide
R803	T1215	T1214	prep	to,clues
R804	T1216	T1217	det	the,evolution
R805	T1217	T1215	pobj	evolution,to
R806	T1218	T1217	prep	of,evolution
R807	T1219	T1220	compound	TACC,function
R808	T1220	T1218	pobj	function,of
R809	T1221	T1167	punct	.,resolve
R811	T1593	T1594	advmod	In,silico
R812	T1594	T1595	amod	silico,identification
R813	T1596	T1595	prep	of,identification
R814	T1597	T1598	compound	TACC,members
R815	T1598	T1596	pobj	members,of
R816	T1599	T1598	compound	family,members
R817	T1600	T1598	prep	from,members
R818	T1601	T1602	nmod	vertebrate,lineages
R819	T1602	T1600	pobj	lineages,from
R820	T1603	T1601	cc	and,vertebrate
R821	T1604	T1601	conj	invertebrate,vertebrate
R822	T1606	T1607	compound	Sequence,similarity
R823	T1607	T1608	compound	similarity,searches
R824	T1608	T1609	nsubjpass	searches,performed
R825	T1610	T1608	prep	of,searches
R826	T1611	T1612	det	the,databases
R827	T1612	T1610	pobj	databases,of
R828	T1613	T1614	advmod	publicly,available
R829	T1614	T1612	amod	available,databases
R830	T1615	T1612	compound	genome,databases
R831	T1616	T1612	prep	with,databases
R832	T1617	T1618	det	the,programs
R833	T1618	T1616	pobj	programs,with
R834	T1619	T1618	nmod	BLAST,programs
R835	T1620	T1619	cc	and,BLAST
R836	T1621	T1619	conj	TBLAST,BLAST
R837	T1622	T1609	auxpass	were,performed
R838	T1623	T1624	aux	to,identify
R839	T1624	T1609	advcl	identify,performed
R840	T1625	T1626	nmod	TACC,orthologues
R841	T1626	T1624	dobj	orthologues,identify
R842	T1627	T1625	cc	and,TACC
R843	T1628	T1625	conj	RHAMM,TACC
R844	T1629	T1626	punct	", ",orthologues
R845	T1630	T1626	cc	and,orthologues
R846	T1631	T1632	amod	other,members
R847	T1632	T1626	conj	members,orthologues
R848	T1633	T1632	prep	of,members
R849	T1634	T1635	det	the,superfamily
R850	T1635	T1633	pobj	superfamily,of
R851	T1636	T1637	amod	coiled,coil
R852	T1637	T1635	compound	coil,superfamily
R853	T1638	T1624	prep	in,identify
R854	T1639	T1640	det	a,set
R855	T1640	T1638	pobj	set,in
R856	T1641	T1640	amod	diverse,set
R857	T1642	T1640	prep	of,set
R858	T1643	T1642	pobj	species,of
R859	T1644	T1645	punct	(,Fig.
R860	T1645	T1624	parataxis	Fig.,identify
R861	T1646	T1645	nummod	1,Fig.
R862	T1647	T1645	punct	),Fig.
R863	T1648	T1609	punct	.,performed
R864	T1650	T1651	nsubj	This,identified
R865	T1652	T1653	det	the,sequence
R866	T1653	T1651	dobj	sequence,identified
R867	T1654	T1653	amod	complete,sequence
R868	T1655	T1653	prep	of,sequence
R869	T1656	T1657	det	the,genes
R870	T1657	T1655	pobj	genes,of
R871	T1658	T1657	compound	TACC,genes
R872	T1659	T1651	prep	in,identified
R873	T1660	T1659	pobj	representatives,in
R874	T1661	T1660	prep	of,representatives
R875	T1662	T1663	nummod	five,clades
R876	T1663	T1661	pobj	clades,of
R877	T1664	T1663	amod	major,clades
R878	T1665	T1666	advmod	phylogenetically,distinct
R879	T1666	T1663	amod	distinct,clades
R880	T1667	T1651	punct	.,identified
R881	T1669	T1670	advmod	Where,possible
R882	T1670	T1671	advcl	possible,confirmed
R883	T1672	T1671	punct	", ",confirmed
R884	T1673	T1674	det	the,construction
R885	T1674	T1671	nsubjpass	construction,confirmed
R886	T1675	T1674	prep	of,construction
R887	T1676	T1677	det	the,sequences
R888	T1677	T1675	pobj	sequences,of
R889	T1678	T1677	compound	TACC,sequences
R890	T1679	T1677	prep	from,sequences
R891	T1680	T1681	det	these,organisms
R892	T1681	T1679	pobj	organisms,from
R893	T1682	T1671	auxpass	was,confirmed
R894	T1683	T1671	advmod	also,confirmed
R895	T1684	T1671	agent	by,confirmed
R896	T1685	T1686	det	the,analysis
R897	T1686	T1684	pobj	analysis,by
R898	T1687	T1686	prep	of,analysis
R899	T1688	T1689	det	the,databases
R900	T1689	T1687	pobj	databases,of
R901	T1690	T1689	compound	cDNA,databases
R902	T1691	T1671	punct	.,confirmed
R903	T1693	T1694	amod	Several,sequences
R904	T1694	T1696	nsubjpass	sequences,identified
R905	T1695	T1694	amod	partial,sequences
R906	T1697	T1694	prep	in,sequences
R907	T1698	T1699	amod	other,species
R908	T1699	T1697	pobj	species,in
R909	T1700	T1699	compound	vertebrate,species
R910	T1701	T1699	punct	", ",species
R911	T1702	T1703	det	the,echinodermate
R912	T1703	T1699	appos	echinodermate,species
R913	T1704	T1705	compound	Strongylocentrotus,purpuratus
R914	T1705	T1703	appos	purpuratus,echinodermate
R915	T1706	T1703	cc	and,echinodermate
R916	T1707	T1708	det	the,insect
R917	T1708	T1703	conj	insect,echinodermate
R918	T1709	T1708	compound	protostome,insect
R919	T1710	T1711	compound	Anopheles,gambiae
R920	T1711	T1708	appos	gambiae,insect
R921	T1712	T1696	auxpass	were,identified
R922	T1713	T1696	advmod	also,identified
R923	T1714	T1696	punct	", ",identified
R924	T1715	T1696	advcl	suggesting,identified
R925	T1716	T1717	det	an,conservation
R926	T1717	T1715	dobj	conservation,suggesting
R927	T1718	T1717	amod	ancient,conservation
R928	T1719	T1717	prep	of,conservation
R929	T1720	T1721	det	the,genes
R930	T1721	T1719	pobj	genes,of
R931	T1722	T1721	compound	TACC,genes
R932	T1723	T1717	prep	in,conservation
R933	T1724	T1725	compound	metazoan,lineages
R934	T1725	T1723	pobj	lineages,in
R935	T1726	T1696	punct	.,identified
R936	T1728	T1729	advmod	However,undertaken
R937	T1730	T1729	punct	", ",undertaken
R938	T1731	T1729	prep	due,undertaken
R939	T1732	T1731	pcomp	to,due
R940	T1733	T1734	det	the,infancy
R941	T1734	T1731	pobj	infancy,due
R942	T1735	T1734	amod	relative,infancy
R943	T1736	T1734	prep	of,infancy
R944	T1737	T1738	det	the,projects
R945	T1738	T1736	pobj	projects,of
R946	T1739	T1740	compound	cDNA,genome
R947	T1740	T1738	compound	genome,projects
R948	T1741	T1740	punct	/,genome
R949	T1742	T1738	prep	for,projects
R950	T1743	T1744	det	these,organisms
R951	T1744	T1742	pobj	organisms,for
R952	T1745	T1744	amod	latter,organisms
R953	T1746	T1729	punct	", ",undertaken
R954	T1747	T1748	amod	complete,characterization
R955	T1748	T1729	nsubjpass	characterization,undertaken
R956	T1749	T1748	prep	of,characterization
R957	T1750	T1751	det	these,genes
R958	T1751	T1749	pobj	genes,of
R959	T1752	T1751	compound	TACC,genes
R960	T1753	T1729	aux	could,undertaken
R961	T1754	T1729	neg	not,undertaken
R962	T1755	T1729	auxpass	be,undertaken
R963	T1756	T1729	punct	.,undertaken
R964	T1758	T1759	det	No,conclusion
R965	T1759	T1760	nsubjpass	conclusion,made
R966	T1761	T1760	aux	could,made
R967	T1762	T1760	auxpass	be,made
R968	T1763	T1760	prep	about,made
R969	T1764	T1765	det	the,existence
R970	T1765	T1763	pobj	existence,about
R971	T1766	T1765	prep	of,existence
R972	T1767	T1768	npadvmod	TACC,like
R973	T1768	T1770	amod	like,sequence
R974	T1769	T1768	punct	-,like
R975	T1770	T1766	pobj	sequence,of
R976	T1771	T1765	prep	in,existence
R977	T1772	T1773	amod	non-bilaterian,metazoans
R978	T1773	T1771	pobj	metazoans,in
R979	T1774	T1773	punct	", ",metazoans
R980	T1775	T1776	amod	such,as
R981	T1776	T1773	prep	as,metazoans
R982	T1777	T1776	pobj	Cnidaria,as
R983	T1778	T1777	cc	or,Cnidaria
R984	T1779	T1777	conj	Porifera,Cnidaria
R985	T1780	T1760	punct	", ",made
R986	T1781	T1760	prep	due,made
R987	T1782	T1781	pcomp	to,due
R988	T1783	T1784	det	the,paucity
R989	T1784	T1781	pobj	paucity,due
R990	T1785	T1784	prep	of,paucity
R991	T1786	T1787	compound	sequence,information
R992	T1787	T1785	pobj	information,of
R993	T1788	T1787	prep	for,information
R994	T1789	T1790	det	these,organisms
R995	T1790	T1788	pobj	organisms,for
R996	T1791	T1760	punct	", ",made
R997	T1792	T1760	cc	and,made
R998	T1793	T1794	amod	additional,sequences
R999	T1794	T1796	nsubjpass	sequences,found
R1000	T1795	T1794	amod	definitive,sequences
R1001	T1796	T1760	conj	found,made
R1002	T1797	T1794	prep	with,sequences
R1003	T1798	T1799	det	a,domain
R1004	T1799	T1797	pobj	domain,with
R1005	T1800	T1799	amod	defined,domain
R1006	T1801	T1799	compound	TACC,domain
R1007	T1802	T1796	aux	could,found
R1008	T1803	T1796	neg	not,found
R1009	T1804	T1796	auxpass	be,found
R1025	T1845	T1833	prep	in,identified
R1026	T1846	T1847	det	the,genome
R1027	T1847	T1845	pobj	genome,in
R1028	T1848	T1847	prep	of,genome
R1029	T1849	T1850	det	the,urochordate
R1030	T1850	T1848	pobj	urochordate,of
R1031	T1851	T1852	compound	Ciona,intestinalis
R1032	T1852	T1850	appos	intestinalis,urochordate
R1033	T1853	T1854	punct	[,11
R1034	T1854	T1850	parataxis	11,urochordate
R1035	T1855	T1854	punct	],11
R1036	T1856	T1847	punct	", ",genome
R1037	T1857	T1847	cc	and,genome
R1038	T1858	T1859	det	a,sequence
R1039	T1859	T1847	conj	sequence,genome
R1040	T1860	T1859	amod	partial,sequence
R1041	T1861	T1859	compound	TACC,sequence
R1042	T1862	T1859	prep	from,sequence
R1043	T1863	T1864	det	an,analysis
R1044	T1864	T1862	pobj	analysis,from
R1045	T1865	T1864	prep	of,analysis
R1046	T1866	T1867	det	the,database
R1047	T1867	T1865	pobj	database,of
R1048	T1868	T1869	compound	Halocynthia,rortezi
R1049	T1869	T1867	compound	rortezi,database
R1050	T1870	T1867	compound	EST,database
R1051	T1871	T1872	punct	[,12
R1052	T1872	T1864	parataxis	12,analysis
R1053	T1873	T1872	punct	],12
R1054	T1874	T1833	punct	.,identified
R1055	T1876	T1877	nsubj	This,confirms
R1056	T1878	T1879	det	the,assumption
R1057	T1879	T1877	dobj	assumption,confirms
R1058	T1880	T1879	amod	original,assumption
R1059	T1881	T1882	mark	that,was
R1060	T1882	T1879	acl	was,assumption
R1061	T1883	T1884	det	a,gene
R1062	T1884	T1882	nsubj	gene,was
R1063	T1885	T1884	amod	single,gene
R1064	T1886	T1884	compound	TACC,gene
R1065	T1887	T1882	acomp	present,was
R1066	T1888	T1882	prep	in,was
R1067	T1889	T1890	det	the,ancestor
R1068	T1890	T1888	pobj	ancestor,in
R1069	T1891	T1890	compound	chordate,ancestor
R1070	T1892	T1877	punct	.,confirms
R1071	T1894	T1895	det	The,event
R1072	T1895	T1898	nsubjpass	event,suggested
R1073	T1896	T1895	amod	next,event
R1074	T1897	T1895	amod	major,event
R1075	T1899	T1895	prep	in,event
R1076	T1900	T1901	det	the,evolution
R1077	T1901	T1899	pobj	evolution,in
R1078	T1902	T1901	prep	of,evolution
R1079	T1903	T1904	det	the,genome
R1080	T1904	T1902	pobj	genome,of
R1081	T1905	T1904	compound	chordate,genome
R1082	T1906	T1898	aux	has,suggested
R1083	T1907	T1898	auxpass	been,suggested
R1084	T1908	T1909	aux	to,occurred
R1085	T1909	T1898	xcomp	occurred,suggested
R1086	T1910	T1909	aux	have,occurred
R1087	T1911	T1912	quantmod	687,155.7
R1088	T1912	T1914	nummod	155.7,years
R1089	T1913	T1912	punct	±,155.7
R1090	T1914	T1916	npadvmod	years,ago
R1091	T1915	T1914	nummod	million,years
R1092	T1916	T1909	advmod	ago,occurred
R1093	T1917	T1918	punct	(,MYA
R1094	T1918	T1916	parataxis	MYA,ago
R1095	T1919	T1918	punct	),MYA
R1096	T1920	T1909	punct	", ",occurred
R1097	T1921	T1909	prep	with,occurred
R1098	T1922	T1923	det	the,duplication
R1099	T1923	T1921	pobj	duplication,with
R1100	T1924	T1923	amod	first,duplication
R1101	T1925	T1923	prep	of,duplication
R1102	T1926	T1927	det	the,genome
R1103	T1927	T1925	pobj	genome,of
R1104	T1928	T1927	compound	chordate,genome
R1105	T1929	T1923	punct	", ",duplication
R1106	T1930	T1923	cc	and,duplication
R1107	T1931	T1932	det	a,duplication
R1108	T1932	T1923	conj	duplication,duplication
R1109	T1933	T1932	amod	second,duplication
R1110	T1934	T1932	acl	occurring,duplication
R1111	T1935	T1936	advmod	shortly,thereafter
R1112	T1936	T1934	advmod	thereafter,occurring
R1113	T1937	T1898	punct	.,suggested
R1114	T1939	T1940	advmod	Thus,expect
R1115	T1941	T1940	punct	", ",expect
R1116	T1942	T1943	mark	if,duplicated
R1117	T1943	T1940	advcl	duplicated,expect
R1118	T1944	T1945	det	the,genes
R1119	T1945	T1943	nsubjpass	genes,duplicated
R1120	T1946	T1945	compound	TACC,genes
R1121	T1947	T1943	auxpass	were,duplicated
R1122	T1948	T1943	prep	at,duplicated
R1123	T1949	T1950	det	both,events
R1124	T1950	T1948	pobj	events,at
R1125	T1951	T1940	punct	", ",expect
R1126	T1952	T1940	nsubj	we,expect
R1127	T1953	T1940	aux	would,expect
R1128	T1954	T1955	aux	to,identify
R1129	T1955	T1940	xcomp	identify,expect
R1130	T1956	T1957	nummod	four,genes
R1131	T1957	T1955	dobj	genes,identify
R1132	T1958	T1957	compound	TACC,genes
R1133	T1959	T1955	prep	in,identify
R1134	T1960	T1961	det	the,genome
R1135	T1961	T1959	pobj	genome,in
R1136	T1962	T1963	amod	most,primitive
R1137	T1963	T1961	amod	primitive,genome
R1138	T1964	T1963	punct	"""",primitive
R1139	T1965	T1963	punct	"""",primitive
R1140	T1966	T1961	amod	compact,genome
R1141	T1967	T1961	compound	vertebrate,genome
R1142	T1968	T1961	acl	sequenced,genome
R1143	T1969	T1961	prep	to,genome
R1144	T1970	T1969	pobj	date,to
R1145	T1971	T1961	punct	", ",genome
R1146	T1972	T1973	det	the,pufferfish
R1147	T1973	T1961	appos	pufferfish,genome
R1148	T1974	T1975	compound	Takifugu,rubripes
R1149	T1975	T1973	appos	rubripes,pufferfish
R1150	T1976	T1973	punct	", ",pufferfish
R1151	T1977	T1973	prep	with,pufferfish
R1152	T1978	T1979	nummod	three,genes
R1153	T1979	T1977	pobj	genes,with
R1154	T1980	T1979	acl	corresponding,genes
R1155	T1981	T1980	prep	to,corresponding
R1156	T1982	T1983	det	the,TACC1
R1157	T1983	T1981	pobj	TACC1,to
R1158	T1984	T1983	amod	human,TACC1
R1159	T1985	T1983	punct	-,TACC1
R1160	T1986	T1983	nummod	3,TACC1
R1161	T1987	T1979	punct	", ",genes
R1162	T1988	T1979	cc	and,genes
R1163	T1989	T1979	punct	", ",genes
R1164	T1990	T1991	prep	in,gene
R1165	T1991	T1979	conj	gene,genes
R1166	T1992	T1990	pobj	keeping,in
R1167	T1993	T1992	prep	with,keeping
R1168	T1994	T1995	det	the,model
R1169	T1995	T1993	pobj	model,with
R1170	T1996	T1995	amod	proposed,model
R1171	T1997	T1995	prep	for,model
R1172	T1998	T1999	amod	genomic,duplication
R1173	T1999	T1997	pobj	duplication,for
R1174	T2000	T1999	prep	of,duplication
R1175	T2001	T2002	det	the,loci
R1176	T2002	T2000	pobj	loci,of
R1177	T2003	T2002	amod	chromosomal,loci
R1178	T2004	T1995	prep	for,model
R1179	T2005	T2006	det	the,genes
R1180	T2006	T2004	pobj	genes,for
R1181	T2007	T2006	compound	TACC,genes
R1182	T2008	T2009	punct	(,discussed
R1183	T2009	T1995	parataxis	discussed,model
R1184	T2010	T2009	advmod	below,discussed
R1185	T2011	T2009	punct	),discussed
R1186	T2012	T1991	punct	", ",gene
R1187	T2013	T1991	det	a,gene
R1188	T2014	T1991	amod	possible,gene
R1189	T2015	T1991	amod	fourth,gene
R1190	T2016	T1991	acl	deriving,gene
R1191	T2017	T2016	prep	from,deriving
R1192	T2018	T2019	det	the,ancestor
R1193	T2019	T2017	pobj	ancestor,from
R1194	T2020	T2019	compound	TACC3,ancestor
R1195	T2021	T1940	punct	.,expect
R1196	T2023	T2024	advmod	Indeed,identified
R1197	T2025	T2024	punct	", ",identified
R1198	T2026	T2027	nummod	four,genes
R1199	T2027	T2024	nsubjpass	genes,identified
R1200	T2028	T2027	compound	TACC,genes
R1201	T2029	T2024	auxpass	were,identified
R1202	T2030	T2024	prep	in,identified
R1203	T2031	T2032	compound	T.,rubripes
R1204	T2032	T2030	pobj	rubripes,in
R1205	T2033	T2024	punct	.,identified
R1206	T2035	T2036	prep	Of,corresponded
R1207	T2037	T2035	pobj	these,Of
R1208	T2038	T2036	punct	", ",corresponded
R1209	T2039	T2040	nummod	two,genes
R1210	T2040	T2036	nsubj	genes,corresponded
R1211	T2041	T2036	prep	to,corresponded
R1212	T2042	T2043	det	the,orthologues
R1213	T2043	T2041	pobj	orthologues,to
R1214	T2044	T2045	compound	T.,rubripes
R1215	T2045	T2043	compound	rubripes,orthologues
R1216	T2046	T2043	prep	of,orthologues
R1217	T2047	T2048	amod	human,TACC2
R1218	T2048	T2046	pobj	TACC2,of
R1219	T2049	T2048	cc	and,TACC2
R1220	T2050	T2048	conj	TACC3,TACC2
R1221	T2051	T2036	punct	.,corresponded
R1222	T2053	T2054	advmod	However,are
R1223	T2055	T2054	punct	", ",are
R1224	T2056	T2057	det	the,genes
R1225	T2057	T2054	nsubj	genes,are
R1226	T2058	T2057	amod	other,genes
R1227	T2059	T2057	nummod	two,genes
R1228	T2060	T2057	punct	", ",genes
R1229	T2061	T2057	appos	trTACC1A,genes
R1230	T2062	T2061	cc	and,trTACC1A
R1231	T2063	T2061	conj	trTACC1B,trTACC1A
R1232	T2064	T2054	advmod	clearly,are
R1233	T2065	T2066	advmod	most,related
R1234	T2066	T2054	acomp	related,are
R1235	T2067	T2066	prep	to,related
R1236	T2068	T2067	pobj	TACC1,to
R1237	T2069	T2070	punct	(,Fig.
R1238	T2070	T2054	parataxis	Fig.,are
R1239	T2071	T2070	nummod	1,Fig.
R1240	T2072	T2070	punct	),Fig.
R1241	T2073	T2054	punct	.,are
R1242	T2075	T2076	mark	Although,is
R1243	T2076	T2078	advcl	is,encodes
R1244	T2077	T2076	nsubj	trTACC1A,is
R1245	T2079	T2080	advmod	highly,homologous
R1246	T2080	T2076	acomp	homologous,is
R1247	T2081	T2080	prep	to,homologous
R1248	T2082	T2081	pobj	trTACC1B,to
R1249	T2083	T2078	punct	", ",encodes
R1250	T2084	T2085	det	the,latter
R1251	T2085	T2078	nsubj	latter,encodes
R1252	T2086	T2087	det	a,protein
R1253	T2087	T2078	dobj	protein,encodes
R1254	T2088	T2089	advmod	significantly,smaller
R1255	T2089	T2087	amod	smaller,protein
R1256	T2090	T2087	amod	predicted,protein
R1257	T2091	T2078	punct	.,encodes
R1258	T2093	T2094	det	The,gene
R1259	T2094	T2096	nsubjpass	gene,encoded
R1260	T2095	T2094	compound	trTACC1B,gene
R1261	T2097	T2096	auxpass	is,encoded
R1262	T2098	T2096	agent	by,encoded
R1263	T2099	T2100	nummod	15,exons
R1264	T2100	T2098	pobj	exons,by
R1265	T2101	T2096	prep	over,encoded
R1266	T2102	T2103	advmod	approximately,7
R1267	T2103	T2104	nummod	7,kb
R1268	T2104	T2101	pobj	kb,over
R1269	T2105	T2104	prep	of,kb
R1270	T2106	T2107	det	the,Scaffold
R1271	T2107	T2105	pobj	Scaffold,of
R1272	T2108	T2107	compound	Takifugu,Scaffold
R1273	T2109	T2107	nummod	191,Scaffold
R1274	T2110	T2111	punct	(,see
R1275	T2111	T2096	parataxis	see,encoded
R1276	T2112	T2111	advmod	below,see
R1277	T2113	T2111	punct	),see
R1278	T2114	T2096	punct	.,encoded
R1279	T2116	T2117	det	A,search
R1280	T2117	T2118	nsubj	search,failed
R1281	T2119	T2117	prep	of,search
R1282	T2120	T2121	det	this,region
R1283	T2121	T2119	pobj	region,of
R1284	T2122	T2117	acl	using,search
R1285	T2123	T2124	det	the,software
R1286	T2124	T2122	dobj	software,using
R1287	T2125	T2126	nmod	trTACC1A,sequence
R1288	T2126	T2124	nmod	sequence,software
R1289	T2127	T2126	cc	and,sequence
R1290	T2128	T2129	compound	gene,prediction
R1291	T2129	T2126	conj	prediction,sequence
R1292	T2130	T2118	aux	has,failed
R1293	T2131	T2132	advmod	so,far
R1294	T2132	T2118	advmod	far,failed
R1295	T2133	T2134	aux	to,identify
R1296	T2134	T2118	xcomp	identify,failed
R1297	T2135	T2136	amod	additional,exons
R1298	T2136	T2134	dobj	exons,identify
R1299	T2137	T2136	prep	of,exons
R1300	T2138	T2137	pobj	trTACC1B,of
R1301	T2139	T2118	punct	.,failed
R1302	T2141	T2142	advmod	However,appears
R1303	T2143	T2142	punct	", ",appears
R1304	T2144	T2142	prep	given,appears
R1305	T2145	T2146	det	the,structure
R1306	T2146	T2144	pobj	structure,given
R1307	T2147	T2148	compound	intron,exon
R1308	T2148	T2146	compound	exon,structure
R1309	T2149	T2148	punct	/,exon
R1310	T2150	T2146	prep	of,structure
R1311	T2151	T2152	det	this,gene
R1312	T2152	T2150	pobj	gene,of
R1313	T2153	T2154	advmod	apparently,complete
R1314	T2154	T2152	amod	complete,gene
R1315	T2155	T2142	punct	", ",appears
R1316	T2156	T2142	nsubj	it,appears
R1317	T2157	T2142	oprd	likely,appears
R1318	T2158	T2159	mark	that,is
R1319	T2159	T2142	ccomp	is,appears
R1320	T2160	T2159	nsubj	trTACC1B,is
R1321	T2161	T2159	acomp	active,is
R1322	T2162	T2159	prep	in,is
R1323	T2163	T2164	det	the,pufferfish
R1324	T2164	T2162	pobj	pufferfish,in
R1325	T2165	T2159	punct	", ",is
R1326	T2166	T2159	cc	and,is
R1327	T2167	T2168	advmod	presumably,fulfils
R1328	T2168	T2159	conj	fulfils,is
R1329	T2169	T2170	preconj	either,function
R1330	T2170	T2168	dobj	function,fulfils
R1331	T2171	T2170	det	a,function
R1332	T2172	T2173	amod	temporal,spatial
R1333	T2173	T2170	amod	spatial,function
R1334	T2174	T2173	punct	-,spatial
R1335	T2175	T2170	amod	specific,function
R1336	T2176	T2170	prep	within,function
R1337	T2177	T2178	det	the,organism
R1338	T2178	T2176	pobj	organism,within
R1339	T2179	T2170	punct	", ",function
R1340	T2180	T2170	cc	or,function
R1341	T2181	T2182	det	a,function
R1342	T2182	T2170	conj	function,function
R1343	T2183	T2182	amod	distinct,function
R1344	T2184	T2182	prep	from,function
R1345	T2185	T2186	det	the,product
R1346	T2186	T2184	pobj	product,from
R1347	T2187	T2186	amod	larger,product
R1348	T2188	T2186	compound	trTACC1A,product
R1349	T2189	T2182	prep	within,function
R1350	T2190	T2191	det	the,cell
R1351	T2191	T2189	pobj	cell,within
R1352	T2192	T2142	punct	.,appears
R1353	T2194	T2195	advmod	Thus,appear
R1354	T2196	T2195	punct	", ",appear
R1355	T2197	T2195	prep	based,appear
R1356	T2198	T2197	prep	upon,based
R1357	T2199	T2200	det	the,loci
R1358	T2200	T2198	pobj	loci,upon
R1359	T2201	T2200	amod	surrounding,loci
R1360	T2202	T2200	amod	chromosomal,loci
R1361	T2203	T2204	punct	(,see
R1362	T2204	T2200	parataxis	see,loci
R1363	T2205	T2204	advmod	below,see
R1364	T2206	T2204	punct	),see
R1365	T2207	T2195	punct	", ",appear
R1366	T2208	T2209	det	the,genes
R1367	T2209	T2195	nsubj	genes,appear
R1368	T2210	T2209	nmod	trTACC1A,genes
R1369	T2211	T2210	cc	and,trTACC1A
R1370	T2212	T2210	conj	trTACC1B,trTACC1A
R1371	T2213	T2214	aux	to,arisen
R1372	T2214	T2195	xcomp	arisen,appear
R1373	T2215	T2214	aux	have,arisen
R1374	T2216	T2214	prep	from,arisen
R1375	T2217	T2218	det	the,duplication
R1376	T2218	T2216	pobj	duplication,from
R1377	T2219	T2218	prep	of,duplication
R1378	T2220	T2221	det	the,segment
R1379	T2221	T2219	pobj	segment,of
R1380	T2222	T2221	amod	chromosomal,segment
R1381	T2223	T2221	acl	containing,segment
R1382	T2224	T2225	det	the,ancestor
R1383	T2225	T2223	dobj	ancestor,containing
R1384	T2226	T2225	compound	teleost,ancestor
R1385	T2227	T2225	compound	TACC1,ancestor
R1386	T2228	T2218	punct	", ",duplication
R1387	T2229	T2218	prep	during,duplication
R1388	T2230	T2231	det	the,duplication
R1389	T2231	T2229	pobj	duplication,during
R1390	T2232	T2231	amod	additional,duplication
R1391	T2233	T2231	amod	partial,duplication
R1392	T2234	T2231	amod	genomic,duplication
R1393	T2235	T2236	dep	that,occurred
R1394	T2236	T2231	relcl	occurred,duplication
R1395	T2237	T2236	prep	in,occurred
R1396	T2238	T2239	det	the,lineage
R1397	T2239	T2237	pobj	lineage,in
R1398	T2240	T2239	compound	teleost,lineage
R1399	T2241	T2195	punct	.,appear
R1400	T2243	T2244	advmod	Therefore,support
R1401	T2245	T2244	punct	", ",support
R1402	T2246	T2247	det	this,analysis
R1403	T2247	T2244	nsubj	analysis,support
R1404	T2248	T2247	prep	of,analysis
R1405	T2249	T2250	compound	T.,rubripes
R1406	T2250	T2248	pobj	rubripes,of
R1407	T2251	T2244	aux	does,support
R1408	T2252	T2244	neg	not,support
R1409	T2253	T2254	det	the,hypothesis
R1410	T2254	T2244	dobj	hypothesis,support
R1411	T2255	T2256	mark	that,included
R1412	T2256	T2254	acl	included,hypothesis
R1413	T2257	T2258	det	the,region
R1414	T2258	T2256	nsubjpass	region,included
R1415	T2259	T2258	acl	surrounding,region
R1416	T2260	T2261	det	the,ancestor
R1417	T2261	T2259	dobj	ancestor,surrounding
R1418	T2262	T2261	compound	TACC3,ancestor
R1419	T2263	T2256	auxpass	was,included
R1420	T2264	T2256	prep	in,included
R1421	T2265	T2266	det	the,round
R1422	T2266	T2264	pobj	round,in
R1423	T2267	T2266	amod	second,round
R1424	T2268	T2266	prep	of,round
R1425	T2269	T2270	nmod	vertebrate,duplication
R1426	T2270	T2268	pobj	duplication,of
R1427	T2271	T2270	amod	genomic,duplication
R1428	T2272	T2244	punct	.,support
R1429	T2274	T2275	nsubj	Examination,led
R1430	T2276	T2274	prep	of,Examination
R1431	T2277	T2278	amod	higher,vertebrates
R1432	T2278	T2276	pobj	vertebrates,of
R1433	T2279	T2275	prep	to,led
R1434	T2280	T2281	det	the,identification
R1435	T2281	T2279	pobj	identification,to
R1436	T2282	T2281	prep	of,identification
R1437	T2283	T2284	compound	splice,variants
R1438	T2284	T2282	pobj	variants,of
R1439	T2285	T2284	prep	of,variants
R1440	T2286	T2285	pobj	TACC1,of
R1441	T2287	T2286	cc	and,TACC1
R1442	T2288	T2286	conj	TACC2,TACC1
R1443	T2289	T2281	prep	in,identification
R1444	T2290	T2291	compound	Mus,musculus
R1445	T2291	T2289	pobj	musculus,in
R1446	T2292	T2281	punct	", ",identification
R1447	T2293	T2281	cc	and,identification
R1448	T2294	T2295	det	the,assembly
R1449	T2295	T2281	conj	assembly,identification
R1450	T2296	T2295	prep	of,assembly
R1451	T2297	T2298	det	the,orthologues
R1452	T2298	T2296	pobj	orthologues,of
R1453	T2299	T2300	advmod	previously,unidentified
R1454	T2300	T2298	amod	unidentified,orthologues
R1455	T2301	T2298	prep	of,orthologues
R1456	T2302	T2301	pobj	TACC1,of
R1457	T2303	T2302	punct	-,TACC1
R1458	T2304	T2302	nummod	3,TACC1
R1459	T2305	T2295	prep	from,assembly
R1460	T2306	T2307	compound	Rattus,norvegus
R1461	T2307	T2305	pobj	norvegus,from
R1462	T2308	T2275	punct	.,led
R1463	T2310	T2311	prep	In,found
R1464	T2312	T2310	pobj	addition,In
R1465	T2313	T2311	punct	", ",found
R1466	T2314	T2315	det	the,sequence
R1467	T2315	T2311	nsubjpass	sequence,found
R1468	T2316	T2315	compound	TACC1X,sequence
R1469	T2317	T2311	auxpass	was,found
R1470	T2318	T2311	prep	on,found
R1471	T2319	T2320	compound	mouse,X
R1472	T2320	T2318	pobj	X,on
R1473	T2321	T2320	compound	chromosome,X
R1474	T2322	T2311	punct	.,found
R1475	T2324	T2325	det	This,gene
R1476	T2325	T2326	nsubjpass	gene,related
R1477	T2326	T2329	ccomp	related,revealed
R1478	T2327	T2326	auxpass	is,related
R1479	T2328	T2326	advmod	clearly,related
R1480	T2330	T2326	prep	to,related
R1481	T2331	T2332	det	the,TACC1
R1482	T2332	T2330	pobj	TACC1,to
R1483	T2333	T2332	compound	mouse,TACC1
R1484	T2334	T2329	punct	", ",revealed
R1485	T2335	T2329	advmod	however,revealed
R1486	T2336	T2329	punct	", ",revealed
R1487	T2337	T2338	amod	further,examination
R1488	T2338	T2329	nsubj	examination,revealed
R1489	T2339	T2340	det	a,repeat
R1490	T2340	T2329	dobj	repeat,revealed
R1491	T2341	T2340	compound	mouse,repeat
R1492	T2342	T2340	compound	B1,repeat
R1493	T2343	T2340	acl	distributed,repeat
R1494	T2344	T2343	prep	over,distributed
R1495	T2345	T2346	det	the,length
R1496	T2346	T2344	pobj	length,over
R1497	T2347	T2346	prep	of,length
R1498	T2348	T2349	det	the,intron
R1499	T2349	T2347	pobj	intron,of
R1500	T2350	T2349	amod	proposed,intron
R1501	T2351	T2329	punct	.,revealed
R1502	T2353	T2354	prep	In,detected
R1503	T2355	T2353	pobj	addition,In
R1504	T2356	T2354	punct	", ",detected
R1505	T2357	T2358	det	no,expression
R1506	T2358	T2354	nsubjpass	expression,detected
R1507	T2359	T2358	prep	of,expression
R1508	T2360	T2359	pobj	TACC1X,of
R1509	T2361	T2354	auxpass	was,detected
R1510	T2362	T2354	prep	in,detected
R1511	T2363	T2364	compound	mouse,RNA
R1512	T2364	T2362	pobj	RNA,in
R1513	T2365	T2354	prep	by,detected
R1514	T2366	T2367	compound	rt,PCR
R1515	T2367	T2369	compound	PCR,analysis
R1516	T2368	T2367	punct	-,PCR
R1517	T2369	T2365	pobj	analysis,by
R1518	T2370	T2371	punct	(,shown
R1519	T2371	T2354	parataxis	shown,detected
R1520	T2372	T2371	nsubj	data,shown
R1521	T2373	T2371	neg	not,shown
R1522	T2374	T2371	punct	),shown
R1523	T2375	T2354	punct	", ",detected
R1524	T2376	T2354	advcl	suggesting,detected
R1525	T2377	T2378	mark	that,is
R1526	T2378	T2376	ccomp	is,suggesting
R1527	T2379	T2380	det	this,sequence
R1528	T2380	T2378	nsubj	sequence,is
R1529	T2381	T2382	det	a,pseudogene
R1530	T2382	T2378	attr	pseudogene,is
R1531	T2383	T2382	amod	processed,pseudogene
R1532	T2384	T2354	punct	.,detected
R1533	T2386	T2387	advmod	Similarly,exist
R1534	T2388	T2387	punct	", ",exist
R1535	T2389	T2390	compound	TACC1,pseudogenes
R1536	T2390	T2387	nsubj	pseudogenes,exist
R1537	T2391	T2387	advmod	also,exist
R1538	T2392	T2387	advcl	spread,exist
R1539	T2393	T2392	prep	over,spread
R1540	T2394	T2395	nummod	22,kb
R1541	T2395	T2393	pobj	kb,over
R1542	T2396	T2395	prep	of,kb
R1543	T2397	T2398	det	the,region
R1544	T2398	T2396	pobj	region,of
R1545	T2399	T2398	amod	centromeric,region
R1546	T2400	T2398	prep	of,region
R1547	T2401	T2402	amod	human,chromosome
R1548	T2402	T2400	pobj	chromosome,of
R1549	T2403	T2402	nummod	10,chromosome
R1550	T2404	T2393	cc	and,over
R1551	T2405	T2393	punct	", ",over
R1552	T2406	T2393	conj	in,over
R1553	T2407	T2406	pobj	8q21,in
R1554	T2408	T2407	punct	", ",8q21
R1555	T2409	T2410	det	a,region
R1556	T2410	T2407	appos	region,8q21
R1557	T2411	T2410	amod	shorter,region
R1558	T2412	T2413	nummod	86,%
R1559	T2413	T2414	npadvmod	%,identical
R1560	T2414	T2410	amod	identical,region
R1561	T2415	T2414	prep	to,identical
R1562	T2416	T2417	det	the,bp
R1563	T2417	T2415	pobj	bp,to
R1564	T2418	T2417	amod	final,bp
R1565	T2419	T2417	nummod	359,bp
R1566	T2420	T2417	prep	of,bp
R1567	T2421	T2422	det	the,region
R1568	T2422	T2420	pobj	region,of
R1569	T2423	T2422	nmod	TACC1,region
R1570	T2424	T2422	nummod	3,region
R1571	T2425	T2424	punct	',3
R1572	T2426	T2422	amod	untranslated,region
R1573	T2427	T2387	punct	.,exist
R1574	T2429	T2430	det	No,pseudogenes
R1575	T2430	T2431	nsubjpass	pseudogenes,identified
R1576	T2432	T2430	acl	corresponding,pseudogenes
R1577	T2433	T2432	prep	to,corresponding
R1578	T2434	T2433	pobj	TACC2,to
R1579	T2435	T2434	cc	or,TACC2
R1580	T2436	T2434	conj	TACC3,TACC2
R1581	T2437	T2431	auxpass	were,identified
R1582	T2438	T2431	prep	in,identified
R1583	T2439	T2440	det	any,species
R1584	T2440	T2438	pobj	species,in
R1585	T2441	T2440	amod	mammalian,species
R1586	T2442	T2431	punct	.,identified
R1587	T2678	T2677	prep	of,Characterization
R1588	T2679	T2680	compound	vertebrate,TACC3
R1589	T2680	T2681	compound	TACC3,orthologues
R1590	T2681	T2678	pobj	orthologues,of
R1591	T2683	T2684	prep	Based,is
R1592	T2685	T2683	prep	upon,Based
R1593	T2686	T2687	amod	current,analysis
R1594	T2687	T2685	pobj	analysis,upon
R1595	T2688	T2687	amod	functional,analysis
R1596	T2689	T2684	punct	", ",is
R1597	T2690	T2691	det	the,characterization
R1598	T2691	T2684	nsubj	characterization,is
R1599	T2692	T2691	prep	of,characterization
R1600	T2693	T2694	compound	TACC3,orthologues
R1601	T2694	T2692	pobj	orthologues,of
R1602	T2695	T2684	acomp	likely,is
R1603	T2696	T2697	aux	to,be
R1604	T2697	T2695	xcomp	be,likely
R1605	T2698	T2697	acomp	pivotal,be
R1606	T2699	T2698	prep	to,pivotal
R1607	T2700	T2699	pcomp	understanding,to
R1608	T2701	T2702	det	the,sequence
R1609	T2702	T2700	dobj	sequence,understanding
R1610	T2703	T2702	cc	and,sequence
R1611	T2704	T2705	amod	functional,evolution
R1612	T2705	T2702	conj	evolution,sequence
R1613	T2706	T2702	prep	of,sequence
R1614	T2707	T2708	det	the,family
R1615	T2708	T2706	pobj	family,of
R1616	T2709	T2708	compound	TACC,family
R1617	T2710	T2708	compound	gene,family
R1618	T2711	T2684	punct	.,is
R1619	T2713	T2714	mark	As,indicated
R1620	T2714	T2715	advcl	indicated,duplicated
R1621	T2716	T2714	advmod	below,indicated
R1622	T2717	T2715	punct	", ",duplicated
R1623	T2718	T2719	det	the,region
R1624	T2719	T2715	nsubjpass	region,duplicated
R1625	T2720	T2719	amod	chromosomal,region
R1626	T2721	T2719	acl	containing,region
R1627	T2722	T2723	det	the,precursors
R1628	T2723	T2721	dobj	precursors,containing
R1629	T2724	T2725	compound	TACC,gene
R1630	T2725	T2723	compound	gene,precursors
R1631	T2726	T2715	auxpass	was,duplicated
R1632	T2727	T2715	advmod	twice,duplicated
R1633	T2728	T2715	prep	during,duplicated
R1634	T2729	T2730	compound	vertebrate,evolution
R1635	T2730	T2728	pobj	evolution,during
R1636	T2731	T2715	punct	.,duplicated
R1637	T2733	T2734	mark	Although,suggests
R1638	T2734	T2746	advcl	suggests,excluded
R1639	T2735	T2736	det	the,analysis
R1640	T2736	T2734	nsubj	analysis,suggests
R1641	T2737	T2736	prep	of,analysis
R1642	T2738	T2739	compound	T.,rubripes
R1643	T2739	T2737	pobj	rubripes,of
R1644	T2740	T2739	punct	", ",rubripes
R1645	T2741	T2739	conj	rodents,rubripes
R1646	T2742	T2741	cc	and,rodents
R1647	T2743	T2741	conj	humans,rodents
R1648	T2744	T2745	advmod	so,far
R1649	T2745	T2734	advmod	far,suggests
R1650	T2747	T2748	mark	that,included
R1651	T2748	T2734	ccomp	included,suggests
R1652	T2749	T2750	det	the,precursor
R1653	T2750	T2748	nsubjpass	precursor,included
R1654	T2751	T2750	compound	vertebrate,precursor
R1655	T2752	T2750	compound	TACC3,precursor
R1656	T2753	T2748	auxpass	was,included
R1657	T2754	T2748	neg	not,included
R1658	T2755	T2748	prep	in,included
R1659	T2756	T2757	det	the,round
R1660	T2757	T2755	pobj	round,in
R1661	T2758	T2757	amod	second,round
R1662	T2759	T2757	prep	of,round
R1663	T2760	T2761	amod	genomic,duplication
R1664	T2761	T2759	pobj	duplication,of
R1665	T2762	T2746	punct	", ",excluded
R1666	T2763	T2746	nsubjpass	it,excluded
R1667	T2764	T2746	aux	could,excluded
R1668	T2765	T2746	neg	not,excluded
R1669	T2766	T2746	auxpass	be,excluded
R1670	T2767	T2768	mark	that,lost
R1671	T2768	T2746	ccomp	lost,excluded
R1672	T2769	T2770	det	a,gene
R1673	T2770	T2768	nsubjpass	gene,lost
R1674	T2771	T2770	compound	TACC4,gene
R1675	T2772	T2768	aux	may,lost
R1676	T2773	T2768	aux	have,lost
R1677	T2774	T2768	auxpass	been,lost
R1678	T2775	T2768	prep	during,lost
R1679	T2776	T2777	det	the,evolution
R1680	T2777	T2775	pobj	evolution,during
R1681	T2778	T2777	prep	of,evolution
R1682	T2779	T2780	det	these,lineages
R1683	T2780	T2778	pobj	lineages,of
R1684	T2781	T2746	punct	.,excluded
R1685	T2783	T2784	det	The,cloning
R1686	T2784	T2785	nsubj	cloning,added
R1687	T2786	T2784	prep	of,cloning
R1688	T2787	T2788	det	a,member
R1689	T2788	T2786	pobj	member,of
R1690	T2789	T2788	amod	new,member
R1691	T2790	T2788	prep	of,member
R1692	T2791	T2792	det	the,family
R1693	T2792	T2790	pobj	family,of
R1694	T2793	T2792	compound	TACC,family
R1695	T2794	T2784	prep	in,cloning
R1696	T2795	T2796	compound	Oryctolagus,cuniculus
R1697	T2796	T2794	pobj	cuniculus,in
R1698	T2797	T2785	aux	has,added
R1699	T2798	T2785	prep	to,added
R1700	T2799	T2800	det	this,controversy
R1701	T2800	T2798	pobj	controversy,to
R1702	T2801	T2802	punct	[,9
R1703	T2802	T2785	parataxis	9,added
R1704	T2803	T2802	punct	],9
R1705	T2804	T2785	punct	.,added
R1706	T2806	T2807	advcl	Designated,was
R1707	T2808	T2806	oprd	TACC4,Designated
R1708	T2809	T2807	punct	", ",was
R1709	T2810	T2811	det	the,cDNA
R1710	T2811	T2807	nsubj	cDNA,was
R1711	T2812	T2813	nummod	1.5,kb
R1712	T2813	T2811	compound	kb,cDNA
R1713	T2814	T2815	advmod	highly,related
R1714	T2815	T2807	acomp	related,was
R1715	T2816	T2815	punct	", ",related
R1716	T2817	T2815	cc	but,related
R1717	T2818	T2815	conj	proposed,related
R1718	T2819	T2820	aux	to,be
R1719	T2820	T2818	xcomp	be,proposed
R1720	T2821	T2820	acomp	distinct,be
R1721	T2822	T2821	prep	from,distinct
R1722	T2823	T2822	pobj	TACC3,from
R1723	T2824	T2807	punct	.,was
R1724	T2826	T2827	advmod	However,suggested
R1725	T2828	T2827	punct	", ",suggested
R1726	T2829	T2830	compound	Northern,blot
R1727	T2830	T2831	compound	blot,data
R1728	T2831	T2827	nsubj	data,suggested
R1729	T2832	T2833	mark	that,produces
R1730	T2833	T2827	ccomp	produces,suggested
R1731	T2834	T2835	det	this,gene
R1732	T2835	T2833	nsubj	gene,produces
R1733	T2836	T2837	det	a,transcript
R1734	T2837	T2833	dobj	transcript,produces
R1735	T2838	T2837	amod	single,transcript
R1736	T2839	T2840	nummod	2.3,kb
R1737	T2840	T2837	compound	kb,transcript
R1738	T2841	T2842	punct	[,9
R1739	T2842	T2833	parataxis	9,produces
R1740	T2843	T2842	punct	],9
R1741	T2844	T2833	punct	", ",produces
R1742	T2845	T2833	advcl	indicating,produces
R1743	T2846	T2847	mark	that,was
R1744	T2847	T2845	ccomp	was,indicating
R1745	T2848	T2849	det	the,cDNA
R1746	T2849	T2847	nsubj	cDNA,was
R1747	T2850	T2849	amod	cloned,cDNA
R1748	T2851	T2847	acomp	incomplete,was
R1749	T2852	T2827	punct	.,suggested
R1750	T2854	T2855	det	The,degree
R1751	T2855	T2856	nsubj	degree,suggested
R1752	T2857	T2855	prep	of,degree
R1753	T2858	T2857	pobj	similarity,of
R1754	T2859	T2858	prep	to,similarity
R1755	T2860	T2861	det	the,sequence
R1756	T2861	T2859	pobj	sequence,to
R1757	T2862	T2861	amod	published,sequence
R1758	T2863	T2861	prep	of,sequence
R1759	T2864	T2865	amod	human,TACC3
R1760	T2865	T2863	pobj	TACC3,of
R1761	T2866	T2864	cc	and,human
R1762	T2867	T2864	conj	mouse,human
R1763	T2868	T2856	prep	to,suggested
R1764	T2869	T2868	pobj	us,to
R1765	T2870	T2871	mark	that,represents
R1766	T2871	T2856	ccomp	represents,suggested
R1767	T2872	T2871	nsubj	TACC4,represents
R1768	T2873	T2871	advmod	actually,represents
R1769	T2874	T2875	det	a,cDNA
R1770	T2875	T2871	dobj	cDNA,represents
R1771	T2876	T2875	amod	partial,cDNA
R1772	T2877	T2875	compound	rabbit,cDNA
R1773	T2878	T2875	compound	TACC3,cDNA
R1774	T2879	T2856	punct	.,suggested
R1775	T2881	T2882	aux	To,test
R1776	T2882	T2883	advcl	test,set
R1777	T2884	T2885	det	this,hypothesis
R1778	T2885	T2882	dobj	hypothesis,test
R1779	T2886	T2883	punct	", ",set
R1780	T2887	T2883	nsubj	we,set
R1781	T2888	T2883	prt	out,set
R1782	T2889	T2890	aux	to,clone
R1783	T2890	T2883	xcomp	clone,set
R1784	T2891	T2892	det	the,sequence
R1785	T2892	T2890	dobj	sequence,clone
R1786	T2893	T2892	amod	complete,sequence
R1787	T2894	T2892	compound	rabbit,sequence
R1788	T2895	T2892	compound	TACC3,sequence
R1789	T2896	T2890	punct	", ",clone
R1790	T2897	T2890	prep	based,clone
R1791	T2898	T2897	prep	upon,based
R1792	T2899	T2900	det	the,features
R1793	T2900	T2898	pobj	features,upon
R1794	T2901	T2900	amod	known,features
R1795	T2902	T2900	prep	of,features
R1796	T2903	T2904	amod	human,TACC3
R1797	T2904	T2902	pobj	TACC3,of
R1798	T2905	T2903	cc	and,human
R1799	T2906	T2903	conj	mouse,human
R1800	T2907	T2883	punct	.,set
R1801	T2909	T2910	nsubj	We,noted
R1802	T2911	T2910	aux	have,noted
R1803	T2912	T2910	advmod	previously,noted
R1804	T2913	T2914	mark	that,are
R1805	T2914	T2910	ccomp	are,noted
R1806	T2915	T2916	det	the,regions
R1807	T2916	T2914	nsubj	regions,are
R1808	T2917	T2918	npadvmod	N,terminal
R1809	T2918	T2916	amod	terminal,regions
R1810	T2919	T2918	punct	-,terminal
R1811	T2920	T2918	cc	and,terminal
R1812	T2921	T2922	npadvmod	C,terminal
R1813	T2922	T2918	conj	terminal,terminal
R1814	T2923	T2922	punct	-,terminal
R1815	T2924	T2916	prep	of,regions
R1816	T2925	T2926	det	the,proteins
R1817	T2926	T2924	pobj	proteins,of
R1818	T2927	T2926	amod	human,proteins
R1819	T2928	T2927	cc	and,human
R1820	T2929	T2927	conj	mouse,human
R1821	T2930	T2926	compound	TACC3,proteins
R1822	T2931	T2932	advmod	highly,conserved
R1823	T2932	T2914	acomp	conserved,are
R1824	T2933	T2934	punct	(,2
R1825	T2934	T2910	parataxis	2,noted
R1826	T2935	T2934	punct	[,2
R1827	T2936	T2934	punct	],2
R1828	T2937	T2934	punct	", ",2
R1829	T2938	T2934	advcl	see,2
R1830	T2939	T2938	advmod	below,see
R1831	T2940	T2934	punct	),2
R1832	T2941	T2910	punct	.,noted
R1833	T2943	T2944	advmod	Therefore,designed
R1834	T2945	T2944	punct	", ",designed
R1835	T2946	T2944	prep	based,designed
R1836	T2947	T2946	prep	upon,based
R1837	T2948	T2949	det	the,identity
R1838	T2949	T2947	pobj	identity,upon
R1839	T2950	T2949	compound	sequence,identity
R1840	T2951	T2949	prep	between,identity
R1841	T2952	T2953	det	these,genes
R1842	T2953	T2951	pobj	genes,between
R1843	T2954	T2944	punct	", ",designed
R1844	T2955	T2944	nsubj	we,designed
R1845	T2956	T2957	det	a,primer
R1846	T2957	T2944	dobj	primer,designed
R1847	T2958	T2957	compound	consensus,primer
R1848	T2959	T2957	compound	oligonucleotide,primer
R1849	T2960	T2957	punct	", ",primer
R1850	T2961	T2957	appos	T3con2,primer
R1851	T2962	T2957	punct	", ",primer
R1852	T2963	T2964	dep	that,be
R1853	T2964	T2957	relcl	be,primer
R1854	T2965	T2964	aux	would,be
R1855	T2966	T2964	acomp	suitable,be
R1856	T2967	T2966	prep	for,suitable
R1857	T2968	T2969	det	the,identification
R1858	T2969	T2967	pobj	identification,for
R1859	T2970	T2969	prep	of,identification
R1860	T2971	T2972	det	the,region
R1861	T2972	T2970	pobj	region,of
R1862	T2973	T2972	acl	containing,region
R1863	T2974	T2975	det	the,methionine
R1864	T2975	T2973	dobj	methionine,containing
R1865	T2976	T2975	compound	initiator,methionine
R1866	T2977	T2975	prep	of,methionine
R1867	T2978	T2979	det	the,cDNAs
R1868	T2979	T2977	pobj	cDNAs,of
R1869	T2980	T2979	compound	TACC3,cDNAs
R1870	T2981	T2979	prep	from,cDNAs
R1871	T2982	T2981	pobj	primates,from
R1872	T2983	T2982	cc	and,primates
R1873	T2984	T2982	conj	rodents,primates
R1874	T2985	T2944	punct	.,designed
R1875	T2987	T2988	advcl	Using,isolated
R1876	T2989	T2990	det	this,primer
R1877	T2990	T2987	dobj	primer,Using
R1878	T2991	T2987	punct	", ",Using
R1879	T2992	T2987	prep	in,Using
R1880	T2993	T2992	pobj	combination,in
R1881	T2994	T2993	prep	with,combination
R1882	T2995	T2996	det	the,primer
R1883	T2996	T2994	pobj	primer,with
R1884	T2997	T2998	npadvmod	TACC4,specific
R1885	T2998	T2996	amod	specific,primer
R1886	T2999	T2998	punct	-,specific
R1887	T3000	T2996	compound	RACE,primer
R1888	T3001	T2996	punct	(,primer
R1889	T3002	T2996	appos	RACE2,primer
R1890	T3003	T2996	punct	),primer
R1891	T3004	T2996	punct	", ",primer
R1892	T3005	T3006	advmod	initially,used
R1893	T3006	T2996	acl	used,primer
R1894	T3007	T3006	agent	by,used
R1895	T3008	T3007	pobj	Steadman,by
R1896	T3009	T3010	advmod	et,al
R1897	T3010	T3008	advmod	al,Steadman
R1898	T3011	T3012	punct	[,9
R1899	T3012	T3006	parataxis	9,used
R1900	T3013	T3012	punct	],9
R1901	T3014	T2988	punct	", ",isolated
R1902	T3015	T2988	nsubj	we,isolated
R1903	T3016	T3017	det	a,product
R1904	T3017	T2988	dobj	product,isolated
R1905	T3018	T3019	nummod	1.5,kb
R1906	T3019	T3020	compound	kb,PCR
R1907	T3020	T3017	compound	PCR,product
R1908	T3021	T2988	prep	from,isolated
R1909	T3022	T3023	compound	rabbit,cDNA
R1910	T3023	T3021	pobj	cDNA,from
R1911	T3024	T3023	compound	brain,cDNA
R1912	T3025	T2988	prep	by,isolated
R1913	T3026	T3027	compound	rt,PCR
R1914	T3027	T3025	pobj	PCR,by
R1915	T3028	T3027	punct	-,PCR
R1916	T3029	T2988	punct	.,isolated
R1917	T3031	T3032	prep	In,generated
R1918	T3033	T3031	pobj	combination,In
R1919	T3034	T3033	prep	with,combination
R1920	T3035	T3036	nummod	3,RACE
R1921	T3036	T3034	pobj	RACE,with
R1922	T3037	T3035	punct	',3
R1923	T3038	T3032	punct	", ",generated
R1924	T3039	T3032	nsubj	this,generated
R1925	T3040	T3041	det	a,cDNA
R1926	T3041	T3032	dobj	cDNA,generated
R1927	T3042	T3041	compound	consensus,cDNA
R1928	T3043	T3041	prep	of,cDNA
R1929	T3044	T3045	nummod	2283,bp
R1930	T3045	T3043	pobj	bp,of
R1931	T3046	T3047	dep	which,corresponds
R1932	T3047	T3041	relcl	corresponds,cDNA
R1933	T3048	T3047	prep	to,corresponds
R1934	T3049	T3050	det	the,size
R1935	T3050	T3048	pobj	size,to
R1936	T3051	T3050	compound	transcript,size
R1937	T3052	T3050	prep	of,size
R1938	T3053	T3054	nummod	2.3,kb
R1939	T3054	T3052	pobj	kb,of
R1940	T3055	T3050	acl	detected,size
R1941	T3056	T3055	prep	by,detected
R1942	T3057	T3058	det	the,sequence
R1943	T3058	T3056	pobj	sequence,by
R1944	T3059	T3058	punct	"""",sequence
R1945	T3060	T3058	nmod	TACC4,sequence
R1946	T3061	T3058	punct	"""",sequence
R1947	T3062	T3058	acl	reported,sequence
R1948	T3063	T3062	prep	in,reported
R1949	T3064	T3063	pobj	Figure,in
R1950	T3065	T3064	nummod	4,Figure
R1951	T3066	T3064	prep	of,Figure
R1952	T3067	T3066	pobj	Steadman,of
R1953	T3068	T3069	advmod	et,al
R1954	T3069	T3067	advmod	al,Steadman
R1955	T3070	T3071	punct	[,9
R1956	T3071	T3062	parataxis	9,reported
R1957	T3072	T3071	punct	],9
R1958	T3073	T3032	punct	.,generated
R1959	T3075	T3076	advmod	Thus,corresponds
R1960	T3077	T3076	punct	", ",corresponds
R1961	T3078	T3079	mark	while,remains
R1962	T3079	T3076	advcl	remains,corresponds
R1963	T3080	T3079	nsubj	it,remains
R1964	T3081	T3079	oprd	possible,remains
R1965	T3082	T3083	mark	that,is
R1966	T3083	T3079	ccomp	is,remains
R1967	T3084	T3085	det	the,sequence
R1968	T3085	T3083	nsubj	sequence,is
R1969	T3086	T3085	punct	"""",sequence
R1970	T3087	T3085	nmod	TACC4,sequence
R1971	T3088	T3085	punct	"""",sequence
R1972	T3089	T3090	det	an,product
R1973	T3090	T3083	attr	product,is
R1974	T3091	T3090	amod	alternative,product
R1975	T3092	T3090	compound	splice,product
R1976	T3093	T3083	punct	", ",is
R1977	T3094	T3083	cc	or,is
R1978	T3095	T3083	conj	is,is
R1979	T3096	T3097	det	the,product
R1980	T3097	T3095	attr	product,is
R1981	T3098	T3097	prep	of,product
R1982	T3099	T3098	pobj	reduplication,of
R1983	T3100	T3099	prep	of,reduplication
R1984	T3101	T3102	det	the,gene
R1985	T3102	T3100	pobj	gene,of
R1986	T3103	T3102	compound	TACC3,gene
R1987	T3104	T3105	punct	(,events
R1988	T3105	T3095	parataxis	events,is
R1989	T3106	T3107	dep	that,be
R1990	T3107	T3105	relcl	be,events
R1991	T3108	T3107	aux	would,be
R1992	T3109	T3107	acomp	specific,be
R1993	T3110	T3109	prep	to,specific
R1994	T3111	T3112	det	the,rabbit
R1995	T3112	T3110	pobj	rabbit,to
R1996	T3113	T3105	punct	),events
R1997	T3114	T3076	punct	", ",corresponds
R1998	T3115	T3116	det	the,transcript
R1999	T3116	T3076	nsubj	transcript,corresponds
R2000	T3117	T3116	amod	only,transcript
R2001	T3118	T3116	acl	detected,transcript
R2002	T3119	T3118	prep	in,detected
R2003	T3120	T3121	compound	rabbit,RNA
R2004	T3121	T3119	pobj	RNA,in
R2005	T3122	T3076	prep	to,corresponds
R2006	T3123	T3124	det	the,size
R2007	T3124	T3122	pobj	size,to
R2008	T3125	T3124	amod	predicted,size
R2009	T3126	T3124	compound	transcript,size
R2010	T3127	T3124	prep	of,size
R2011	T3128	T3129	det	the,sequence
R2012	T3129	T3127	pobj	sequence,of
R2013	T3130	T3129	compound	TACC3,sequence
R2014	T3131	T3132	dep	that,identified
R2015	T3132	T3124	relcl	identified,size
R2016	T3133	T3132	nsubj	we,identified
R2017	T3134	T3132	aux	have,identified
R2018	T3135	T3132	advmod	here,identified
R2019	T3136	T3076	punct	.,corresponds
R2020	T3138	T3139	advmod	Furthermore,found
R2021	T3140	T3139	punct	", ",found
R2022	T3141	T3142	det	the,string
R2023	T3142	T3139	nsubjpass	string,found
R2024	T3143	T3142	prep	of,string
R2025	T3144	T3143	pobj	nucleotides,of
R2026	T3145	T3144	acl	found,nucleotides
R2027	T3146	T3145	prep	at,found
R2028	T3147	T3148	det	the,end
R2029	T3148	T3146	pobj	end,at
R2030	T3149	T3148	nummod	5,end
R2031	T3150	T3149	punct	',5
R2032	T3151	T3148	prep	of,end
R2033	T3152	T3153	det	the,sequence
R2034	T3153	T3151	pobj	sequence,of
R2035	T3154	T3153	punct	"""",sequence
R2036	T3155	T3153	nmod	TACC4,sequence
R2037	T3156	T3153	punct	"""",sequence
R2038	T3157	T3139	auxpass	is,found
R2039	T3158	T3139	advmod	also,found
R2040	T3159	T3139	prep	at,found
R2041	T3160	T3161	det	the,ends
R2042	T3161	T3159	pobj	ends,at
R2043	T3162	T3161	nummod	5,ends
R2044	T3163	T3162	punct	',5
R2045	T3164	T3161	prep	of,ends
R2046	T3165	T3166	det	a,number
R2047	T3166	T3164	pobj	number,of
R2048	T3167	T3166	prep	of,number
R2049	T3168	T3169	compound	cDNA,sequences
R2050	T3169	T3167	pobj	sequences,of
R2051	T3170	T3169	punct	(,sequences
R2052	T3171	T3172	advmod	e.g.,NM_023500
R2053	T3172	T3169	appos	NM_023500,sequences
R2054	T3173	T3172	nmod	U82468,NM_023500
R2055	T3174	T3172	punct	", ",NM_023500
R2056	T3175	T3169	punct	),sequences
R2057	T3176	T3169	punct	", ",sequences
R2058	T3177	T3178	dep	that,isolated
R2059	T3178	T3169	relcl	isolated,sequences
R2060	T3179	T3178	auxpass	were,isolated
R2061	T3180	T3178	agent	by,isolated
R2062	T3181	T3182	nummod	5,RACE
R2063	T3182	T3180	pobj	RACE,by
R2064	T3183	T3181	punct	',5
R2065	T3184	T3139	punct	", ",found
R2066	T3185	T3139	advcl	suggesting,found
R2067	T3186	T3187	mark	that,correspond
R2068	T3187	T3185	ccomp	correspond,suggesting
R2069	T3188	T3187	nsubj	they,correspond
R2070	T3189	T3187	aux	may,correspond
R2071	T3190	T3187	prep	to,correspond
R2072	T3191	T3192	det	an,artefact
R2073	T3192	T3190	pobj	artefact,to
R2074	T3193	T3192	prep	of,artefact
R2075	T3194	T3195	det	the,methodology
R2076	T3195	T3193	pobj	methodology,of
R2077	T3196	T3195	nummod	5,methodology
R2078	T3197	T3196	punct	',5
R2079	T3198	T3195	compound	RACE,methodology
R2080	T3199	T3195	acl	used,methodology
R2081	T3200	T3199	prep	in,used
R2082	T3201	T3202	poss	their,construction
R2083	T3202	T3200	pobj	construction,in
R2084	T3203	T3139	punct	.,found
R2085	T3205	T3206	det	The,TACC4
R2086	T3206	T3209	nsubjpass	TACC4,found
R2087	T3207	T3206	nmod	rabbit,TACC4
R2088	T3208	T3206	punct	"""",TACC4
R2089	T3210	T3206	punct	"""",TACC4
R2090	T3211	T3206	cc	and,TACC4
R2091	T3212	T3213	det	the,TACC3
R2092	T3213	T3215	compound	TACC3,sequence
R2093	T3214	T3213	compound	rabbit,TACC3
R2094	T3215	T3206	conj	sequence,TACC4
R2095	T3216	T3217	dep	that,isolated
R2096	T3217	T3206	relcl	isolated,TACC4
R2097	T3218	T3217	nsubj	we,isolated
R2098	T3219	T3217	aux	have,isolated
R2099	T3220	T3209	auxpass	are,found
R2100	T3221	T3209	advmod	also,found
R2101	T3222	T3209	prep	on,found
R2102	T3223	T3224	det	the,branch
R2103	T3224	T3222	pobj	branch,on
R2104	T3225	T3224	amod	same,branch
R2105	T3226	T3224	prep	of,branch
R2106	T3227	T3228	det	the,tree
R2107	T3228	T3226	pobj	tree,of
R2108	T3229	T3228	nmod	TACC,tree
R2109	T3230	T3228	amod	phylogenetic,tree
R2110	T3231	T3209	prep	with,found
R2111	T3232	T3233	det	the,orthologues
R2112	T3233	T3231	pobj	orthologues,with
R2113	T3234	T3233	amod	other,orthologues
R2114	T3235	T3233	compound	TACC3,orthologues
R2115	T3236	T3233	punct	", ",orthologues
R2116	T3237	T3233	prep	including,orthologues
R2117	T3238	T3237	pobj	maskin,including
R2118	T3239	T3238	punct	(,maskin
R2119	T3240	T3241	compound	Xenopus,laevis
R2120	T3241	T3238	appos	laevis,maskin
R2121	T3242	T3238	punct	),maskin
R2122	T3243	T3238	punct	", ",maskin
R2123	T3244	T3238	cc	and,maskin
R2124	T3245	T3246	det	the,sequences
R2125	T3246	T3238	conj	sequences,maskin
R2126	T3247	T3248	advmod	newly,identified
R2127	T3248	T3246	amod	identified,sequences
R2128	T3249	T3246	compound	TACC3,sequences
R2129	T3250	T3246	prep	in,sequences
R2130	T3251	T3252	compound	Rattus,norvegus
R2131	T3252	T3250	pobj	norvegus,in
R2132	T3253	T3252	punct	", ",norvegus
R2133	T3254	T3255	compound	Gallus,gallus
R2134	T3255	T3252	conj	gallus,norvegus
R2135	T3256	T3255	punct	", ",gallus
R2136	T3257	T3258	compound	Silurana,tropicalis
R2137	T3258	T3255	conj	tropicalis,gallus
R2138	T3259	T3258	punct	", ",tropicalis
R2139	T3260	T3261	compound	Danio,rerio
R2140	T3261	T3258	conj	rerio,tropicalis
R2141	T3262	T3261	cc	and,rerio
R2142	T3263	T3264	compound	T.,rubripes
R2143	T3264	T3261	conj	rubripes,rerio
R2144	T3265	T3246	punct	", ",sequences
R2145	T3266	T3246	acl	reported,sequences
R2146	T3267	T3266	prep	in,reported
R2147	T3268	T3269	det	this,manuscript
R2148	T3269	T3267	pobj	manuscript,in
R2149	T3270	T3271	punct	(,Fig.
R2150	T3271	T3209	parataxis	Fig.,found
R2151	T3272	T3271	nummod	1,Fig.
R2152	T3273	T3271	punct	),Fig.
R2153	T3274	T3209	punct	.,found
R2154	T3276	T3277	advmod	Thus,is
R2155	T3278	T3277	punct	", ",is
R2156	T3279	T3277	nsubj	it,is
R2157	T3280	T3277	neg	not,is
R2158	T3281	T3277	prep	in,is
R2159	T3282	T3283	det	a,branch
R2160	T3283	T3281	pobj	branch,in
R2161	T3284	T3283	amod	separate,branch
R2162	T3285	T3286	dep	that,expected
R2163	T3286	T3283	relcl	expected,branch
R2164	T3287	T3286	aux	may,expected
R2165	T3288	T3286	auxpass	be,expected
R2166	T3289	T3290	mark	if,was
R2167	T3290	T3277	advcl	was,is
R2168	T3291	T3292	det	the,sequence
R2169	T3292	T3290	nsubj	sequence,was
R2170	T3293	T3294	det	a,member
R2171	T3294	T3290	attr	member,was
R2172	T3295	T3294	amod	distinct,member
R2173	T3296	T3294	compound	TACC,member
R2174	T3297	T3294	compound	family,member
R2175	T3298	T3277	punct	.,is
R2176	T3413	T3412	prep	of,Placement
R2177	T3414	T3415	det	the,gene
R2178	T3415	T3413	pobj	gene,of
R2179	T3416	T3415	compound	RHAMM,gene
R2180	T3417	T3412	prep	in,Placement
R2181	T3418	T3419	det	the,phylogeny
R2182	T3419	T3417	pobj	phylogeny,in
R2183	T3420	T3419	prep	of,phylogeny
R2184	T3421	T3422	det	the,family
R2185	T3422	T3420	pobj	family,of
R2186	T3423	T3424	amod	coiled,coil
R2187	T3424	T3422	compound	coil,family
R2188	T3425	T3422	compound	gene,family
R2189	T3427	T3428	amod	Human,RHAMM
R2190	T3428	T3429	nsubjpass	RHAMM,proposed
R2191	T3430	T3429	aux	has,proposed
R2192	T3431	T3429	advmod	also,proposed
R2193	T3432	T3429	auxpass	been,proposed
R2194	T3433	T3434	aux	to,be
R2195	T3434	T3429	xcomp	be,proposed
R2196	T3435	T3436	det	the,member
R2197	T3436	T3434	attr	member,be
R2198	T3437	T3436	amod	missing,member
R2199	T3438	T3436	amod	fourth,member
R2200	T3439	T3436	prep	of,member
R2201	T3440	T3441	det	the,family
R2202	T3441	T3439	pobj	family,of
R2203	T3442	T3441	compound	TACC,family
R2204	T3443	T3444	punct	[,10
R2205	T3444	T3429	parataxis	10,proposed
R2206	T3445	T3444	punct	],10
R2207	T3446	T3429	punct	.,proposed
R2208	T3448	T3449	nsubj	Evidence,included
R2209	T3450	T3448	acl	used,Evidence
R2210	T3451	T3450	prep	in,used
R2211	T3452	T3451	pobj	support,in
R2212	T3453	T3452	prep	of,support
R2213	T3454	T3455	det	this,claim
R2214	T3455	T3453	pobj	claim,of
R2215	T3456	T3457	poss	its,location
R2216	T3457	T3449	dobj	location,included
R2217	T3458	T3457	amod	chromosomal,location
R2218	T3459	T3457	prep	on,location
R2219	T3460	T3459	pobj	5q32,on
R2220	T3461	T3457	prep	in,location
R2221	T3462	T3461	pobj	humans,in
R2222	T3463	T3464	punct	(,discussed
R2223	T3464	T3457	parataxis	discussed,location
R2224	T3465	T3464	advmod	below,discussed
R2225	T3466	T3464	punct	),discussed
R2226	T3467	T3457	punct	", ",location
R2227	T3468	T3469	poss	its,similarity
R2228	T3469	T3457	conj	similarity,location
R2229	T3470	T3469	compound	sequence,similarity
R2230	T3471	T3469	prep	in,similarity
R2231	T3472	T3473	poss	its,domain
R2232	T3473	T3471	pobj	domain,in
R2233	T3474	T3475	amod	coiled,coil
R2234	T3475	T3473	compound	coil,domain
R2235	T3476	T3469	prep	to,similarity
R2236	T3477	T3478	det	the,domain
R2237	T3478	T3476	pobj	domain,to
R2238	T3479	T3478	compound	TACC,domain
R2239	T3480	T3469	cc	and,similarity
R2240	T3481	T3482	det	the,localization
R2241	T3482	T3469	conj	localization,similarity
R2242	T3483	T3482	amod	subcellular,localization
R2243	T3484	T3482	prep	of,localization
R2244	T3485	T3486	det	the,protein
R2245	T3486	T3484	pobj	protein,of
R2246	T3487	T3486	compound	RHAMM,protein
R2247	T3488	T3482	prep	in,localization
R2248	T3489	T3490	det	the,centrosome
R2249	T3490	T3488	pobj	centrosome,in
R2250	T3491	T3449	punct	.,included
R2251	T3493	T3494	advmod	However,predict
R2252	T3495	T3494	punct	", ",predict
R2253	T3496	T3497	mark	if,were
R2254	T3497	T3494	advcl	were,predict
R2255	T3498	T3497	nsubj	RHAMM,were
R2256	T3499	T3500	det	a,member
R2257	T3500	T3497	attr	member,were
R2258	T3501	T3502	advmod	bona,fide
R2259	T3502	T3500	amod	fide,member
R2260	T3503	T3500	compound	TACC,member
R2261	T3504	T3500	compound	family,member
R2262	T3505	T3494	punct	", ",predict
R2263	T3506	T3494	advmod	then,predict
R2264	T3507	T3494	nsubj	we,predict
R2265	T3508	T3494	aux	would,predict
R2266	T3509	T3510	poss	its,evolution
R2267	T3510	T3511	nsubj	evolution,be
R2268	T3511	T3494	advcl	be,predict
R2269	T3512	T3511	aux	would,be
R2270	T3513	T3511	acomp	similar,be
R2271	T3514	T3513	prep	to,similar
R2272	T3515	T3514	pobj	those,to
R2273	T3516	T3515	prep	of,those
R2274	T3517	T3518	amod	other,members
R2275	T3518	T3516	pobj	members,of
R2276	T3519	T3518	compound	TACC,members
R2277	T3520	T3518	compound	family,members
R2278	T3521	T3511	punct	", ",be
R2279	T3522	T3511	cc	and,be
R2280	T3523	T3511	conj	fit,be
R2281	T3524	T3523	prep	with,fit
R2282	T3525	T3526	det	the,evolution
R2283	T3526	T3524	pobj	evolution,with
R2284	T3527	T3526	amod	proposed,evolution
R2285	T3528	T3526	prep	of,evolution
R2286	T3529	T3530	det	the,genome
R2287	T3530	T3528	pobj	genome,of
R2288	T3531	T3530	compound	vertebrate,genome
R2289	T3532	T3494	punct	.,predict
R2290	T3534	T3535	advmod	Thus,set
R2291	T3536	T3535	punct	", ",set
R2292	T3537	T3535	nsubj	we,set
R2293	T3538	T3535	prt	out,set
R2294	T3539	T3540	aux	to,identify
R2295	T3540	T3535	advcl	identify,set
R2296	T3541	T3542	compound	RHAMM,orthologues
R2297	T3542	T3540	dobj	orthologues,identify
R2298	T3543	T3542	cc	and,orthologues
R2299	T3544	T3545	amod	related,genes
R2300	T3545	T3542	conj	genes,orthologues
R2301	T3546	T3540	prep	in,identify
R2302	T3547	T3546	pobj	metazoans,in
R2303	T3548	T3540	punct	", ",identify
R2304	T3549	T3550	mark	so,generated
R2305	T3550	T3540	advcl	generated,identify
R2306	T3551	T3550	mark	that,generated
R2307	T3552	T3553	det	a,phylogeny
R2308	T3553	T3550	nsubjpass	phylogeny,generated
R2309	T3554	T3555	advmod	more,complete
R2310	T3555	T3553	amod	complete,phylogeny
R2311	T3556	T3553	prep	of,phylogeny
R2312	T3557	T3558	det	the,family
R2313	T3558	T3556	pobj	family,of
R2314	T3559	T3560	amod	coiled,coil
R2315	T3560	T3558	nmod	coil,family
R2316	T3561	T3558	amod	super,family
R2317	T3562	T3550	aux	could,generated
R2318	T3563	T3550	auxpass	be,generated
R2319	T3564	T3535	punct	.,set
R2320	T3566	T3567	nsubj	We,identified
R2321	T3568	T3569	det	a,gene
R2322	T3569	T3567	dobj	gene,identified
R2323	T3570	T3569	amod	single,gene
R2324	T3571	T3569	compound	RHAMM,gene
R2325	T3572	T3567	prep	in,identified
R2326	T3573	T3574	det	all,deuterostomes
R2327	T3574	T3572	pobj	deuterostomes,in
R2328	T3575	T3576	prep	for,was
R2329	T3576	T3574	relcl	was,deuterostomes
R2330	T3577	T3575	pobj	which,for
R2331	T3578	T3579	nmod	cDNA,sequence
R2332	T3579	T3576	nsubj	sequence,was
R2333	T3580	T3578	cc	and,cDNA
R2334	T3581	T3580	punct	/,and
R2335	T3582	T3580	cc	or,and
R2336	T3583	T3578	conj	genomic,cDNA
R2337	T3584	T3576	acomp	available,was
R2338	T3585	T3576	punct	", ",was
R2339	T3586	T3576	prep	including,was
R2340	T3587	T3588	compound	C.,intestinalis
R2341	T3588	T3586	pobj	intestinalis,including
R2342	T3589	T3567	punct	.,identified
R2343	T3591	T3592	det	No,gene
R2344	T3592	T3594	nsubjpass	gene,identified
R2345	T3593	T3592	compound	RHAMM,gene
R2346	T3595	T3594	auxpass	was,identified
R2347	T3596	T3594	prep	in,identified
R2348	T3597	T3596	pobj	insects,in
R2349	T3598	T3597	cc	or,insects
R2350	T3599	T3597	conj	nematodes,insects
R2351	T3600	T3594	punct	.,identified
R2352	T3602	T3603	nsubj	This,indicates
R2353	T3604	T3605	mark	that,diverged
R2354	T3605	T3603	ccomp	diverged,indicates
R2355	T3606	T3607	det	the,genes
R2356	T3607	T3605	nsubj	genes,diverged
R2357	T3608	T3609	compound	RHAMM,TACC
R2358	T3609	T3607	compound	TACC,genes
R2359	T3610	T3609	punct	/,TACC
R2360	T3611	T3612	mark	after,split
R2361	T3612	T3605	advcl	split,diverged
R2362	T3613	T3614	det	the,deuterostome
R2363	T3614	T3612	nsubj	deuterostome,split
R2364	T3615	T3614	compound	protostome,deuterostome
R2365	T3616	T3614	punct	/,deuterostome
R2366	T3617	T3618	quantmod	833,933
R2367	T3618	T3620	npadvmod	933,MYA
R2368	T3619	T3618	punct	–,933
R2369	T3620	T3612	advmod	MYA,split
R2370	T3621	T3620	punct	", ",MYA
R2371	T3622	T3620	cc	but,MYA
R2372	T3623	T3620	conj	prior,MYA
R2373	T3624	T3623	prep	to,prior
R2374	T3625	T3626	det	the,divergence
R2375	T3626	T3624	pobj	divergence,to
R2376	T3627	T3628	compound	echinodermata,urochordate
R2377	T3628	T3626	compound	urochordate,divergence
R2378	T3629	T3628	punct	/,urochordate
R2379	T3630	T3631	punct	(,MYA
R2380	T3631	T3626	parataxis	MYA,divergence
R2381	T3632	T3633	punct	>,750
R2382	T3633	T3631	npadvmod	750,MYA
R2383	T3634	T3631	punct	),MYA
R2384	T3635	T3603	punct	.,indicates
R2385	T3637	T3638	advmod	Significantly,shows
R2386	T3639	T3638	punct	", ",shows
R2387	T3640	T3641	nmod	sequence,analysis
R2388	T3641	T3638	nsubj	analysis,shows
R2389	T3642	T3640	cc	and,sequence
R2390	T3643	T3640	conj	phylogenetic,sequence
R2391	T3644	T3641	prep	of,analysis
R2392	T3645	T3646	amod	coiled,coil
R2393	T3646	T3647	compound	coil,proteins
R2394	T3647	T3644	pobj	proteins,of
R2395	T3648	T3649	punct	(,Fig.
R2396	T3649	T3641	parataxis	Fig.,analysis
R2397	T3650	T3649	nummod	1,Fig.
R2398	T3651	T3649	punct	),Fig.
R2399	T3652	T3638	advmod	clearly,shows
R2400	T3653	T3654	mark	that,contain
R2401	T3654	T3638	ccomp	contain,shows
R2402	T3655	T3654	nsubj	RHAMM,contain
R2403	T3656	T3654	aux	does,contain
R2404	T3657	T3654	neg	not,contain
R2405	T3658	T3659	det	a,domain
R2406	T3659	T3654	dobj	domain,contain
R2407	T3660	T3659	compound	TACC,domain
R2408	T3661	T3654	cc	and,contain
R2409	T3662	T3663	advmod	instead,forms
R2410	T3663	T3654	conj	forms,contain
R2411	T3664	T3665	det	a,family
R2412	T3665	T3663	dobj	family,forms
R2413	T3666	T3665	amod	distinct,family
R2414	T3667	T3665	prep	of,family
R2415	T3668	T3667	pobj	proteins,of
R2416	T3669	T3663	prep	in,forms
R2417	T3670	T3671	det	the,superfamily
R2418	T3671	T3669	pobj	superfamily,in
R2419	T3672	T3673	amod	coiled,coil
R2420	T3673	T3671	compound	coil,superfamily
R2421	T3674	T3654	punct	", ",contain
R2422	T3675	T3654	cc	and,contain
R2423	T3676	T3654	conj	is,contain
R2424	T3677	T3676	neg	not,is
R2425	T3678	T3679	det	a,descendant
R2426	T3679	T3676	attr	descendant,is
R2427	T3680	T3679	amod	direct,descendant
R2428	T3681	T3679	prep	of,descendant
R2429	T3682	T3683	det	the,gene
R2430	T3683	T3681	pobj	gene,of
R2431	T3684	T3683	amod	ancestral,gene
R2432	T3685	T3683	compound	TACC,gene
R2433	T3686	T3638	punct	.,shows
R2443	T4146	T4145	prep	of,Evolution
R2444	T4147	T4148	det	the,segments
R2445	T4148	T4146	pobj	segments,of
R2446	T4149	T4148	amod	chromosomal,segments
R2447	T4150	T4148	acl	containing,segments
R2448	T4151	T4152	det	the,genes
R2449	T4152	T4150	dobj	genes,containing
R2450	T4153	T4152	compound	TACC,genes
R2451	T4155	T4156	det	The,tree
R2452	T4156	T4158	nsubj	tree,resembles
R2453	T4157	T4156	amod	phylogenetic,tree
R2454	T4159	T4156	prep	of,tree
R2455	T4160	T4161	det	the,genes
R2456	T4161	T4159	pobj	genes,of
R2457	T4162	T4161	compound	FGFR,genes
R2458	T4163	T4158	advmod	closely,resembles
R2459	T4164	T4158	dobj	that,resembles
R2460	T4165	T4164	prep	of,that
R2461	T4166	T4167	det	the,genes
R2462	T4167	T4165	pobj	genes,of
R2463	T4168	T4167	nmod	vertebrate,genes
R2464	T4169	T4167	nmod	TACC1,genes
R2465	T4170	T4169	punct	-,TACC1
R2466	T4171	T4169	nummod	3,TACC1
R2467	T4172	T4158	punct	.,resembles
R2468	T4174	T4175	advmod	Recently,revealed
R2469	T4176	T4175	punct	", ",revealed
R2470	T4177	T4178	amod	detailed,analyses
R2471	T4178	T4175	nsubj	analyses,revealed
R2472	T4179	T4178	prep	of,analyses
R2473	T4180	T4181	det	the,regions
R2474	T4181	T4179	pobj	regions,of
R2475	T4182	T4181	amod	chromosomal,regions
R2476	T4183	T4181	acl	containing,regions
R2477	T4184	T4185	det	the,family
R2478	T4185	T4183	dobj	family,containing
R2479	T4186	T4185	compound	FGFR,family
R2480	T4187	T4185	compound	gene,family
R2481	T4188	T4183	prep	in,containing
R2482	T4189	T4188	pobj	humans,in
R2483	T4190	T4189	punct	", ",humans
R2484	T4191	T4189	conj	mouse,humans
R2485	T4192	T4191	cc	and,mouse
R2486	T4193	T4194	det	the,arthopod
R2487	T4194	T4191	conj	arthopod,mouse
R2488	T4195	T4196	compound	D.,melanogaster
R2489	T4196	T4194	appos	melanogaster,arthopod
R2490	T4197	T4175	aux	have,revealed
R2491	T4198	T4199	det	the,conservation
R2492	T4199	T4175	dobj	conservation,revealed
R2493	T4200	T4199	prep	of,conservation
R2494	T4201	T4202	amod	paralogous,segments
R2495	T4202	T4200	pobj	segments,of
R2496	T4203	T4202	amod	chromosomal,segments
R2497	T4204	T4199	prep	between,conservation
R2498	T4205	T4206	det	these,organisms
R2499	T4206	T4204	pobj	organisms,between
R2500	T4207	T4208	punct	(,Table
R2501	T4208	T4175	parataxis	Table,revealed
R2502	T4209	T4208	dep	Fig.,Table
R2503	T4210	T4209	nummod	2,Fig.
R2504	T4211	T4208	punct	", ",Table
R2505	T4212	T4208	punct	[,Table
R2506	T4213	T4208	dep	13,Table
R2507	T4214	T4208	punct	],Table
R2508	T4215	T4208	punct	", ",Table
R2509	T4216	T4208	nummod	1,Table
R2510	T4217	T4208	punct	[,Table
R2511	T4218	T4208	advcl	see,Table
R2512	T4219	T4220	amod	Additional,file
R2513	T4220	T4218	dobj	file,see
R2514	T4221	T4220	nummod	1,file
R2515	T4222	T4208	punct	],Table
R2516	T4223	T4208	punct	),Table
R2517	T4224	T4175	punct	.,revealed
R2518	T4226	T4227	nsubj	This,provided
R2519	T4228	T4227	aux	has,provided
R2520	T4229	T4230	amod	further,support
R2521	T4230	T4227	dobj	support,provided
R2522	T4231	T4232	mark	that,duplicated
R2523	T4232	T4230	acl	duplicated,support
R2524	T4233	T4234	det	an,segment
R2525	T4234	T4232	nsubjpass	segment,duplicated
R2526	T4235	T4234	amod	ancient,segment
R2527	T4236	T4234	amod	chromosomal,segment
R2528	T4237	T4232	auxpass	was,duplicated
R2529	T4238	T4232	advmod	twice,duplicated
R2530	T4239	T4232	prep	during,duplicated
R2531	T4240	T4241	compound	vertebrate,evolution
R2532	T4241	T4239	pobj	evolution,during
R2533	T4242	T4232	punct	", ",duplicated
R2534	T4243	T4232	prep	with,duplicated
R2535	T4244	T4245	det	the,duplication
R2536	T4245	T4247	nsubj	duplication,occurring
R2537	T4246	T4245	amod	first,duplication
R2538	T4247	T4243	pcomp	occurring,with
R2539	T4248	T4249	dep	that,gave
R2540	T4249	T4245	relcl	gave,duplication
R2541	T4250	T4249	dobj	rise,gave
R2542	T4251	T4249	prep	to,gave
R2543	T4252	T4253	det	the,ancestors
R2544	T4253	T4251	pobj	ancestors,to
R2545	T4254	T4255	amod	human,chromosome
R2546	T4255	T4256	nmod	chromosome,ter
R2547	T4256	T4253	nmod	ter,ancestors
R2548	T4257	T4258	nmod	4p16,5q32
R2549	T4258	T4256	nmod	5q32,ter
R2550	T4259	T4258	punct	/,5q32
R2551	T4260	T4256	punct	-,ter
R2552	T4261	T4256	cc	and,ter
R2553	T4262	T4263	amod	human,chromosome
R2554	T4263	T4264	compound	chromosome,ter
R2555	T4264	T4256	conj	ter,ter
R2556	T4265	T4266	compound	8p,10q23
R2557	T4266	T4264	compound	10q23,ter
R2558	T4267	T4266	punct	/,10q23
R2559	T4268	T4264	punct	-,ter
R2560	T4269	T4247	prep	in,occurring
R2561	T4270	T4271	det	the,stages
R2562	T4271	T4269	pobj	stages,in
R2563	T4272	T4271	amod	early,stages
R2564	T4273	T4271	prep	after,stages
R2565	T4274	T4275	det	the,divergence
R2566	T4275	T4273	pobj	divergence,after
R2567	T4276	T4275	compound	invertebrate,divergence
R2568	T4277	T4227	punct	.,provided
R2569	T4279	T4280	nsubj	This,suggests
R2570	T4281	T4282	mark	that,arose
R2571	T4282	T4280	ccomp	arose,suggests
R2572	T4283	T4284	det	the,pair
R2573	T4284	T4282	nsubj	pair,arose
R2574	T4285	T4284	amod	ancestral,pair
R2575	T4286	T4287	compound	FGFR,TACC
R2576	T4287	T4284	compound	TACC,pair
R2577	T4288	T4287	punct	-,TACC
R2578	T4289	T4284	compound	gene,pair
R2579	T4290	T4291	advmod	most,probably
R2580	T4291	T4282	advmod	probably,arose
R2581	T4292	T4293	amod	prior,to
R2582	T4293	T4282	prep	to,arose
R2583	T4294	T4295	det	the,duplication
R2584	T4295	T4293	pobj	duplication,to
R2585	T4296	T4295	amod	initial,duplication
R2586	T4297	T4295	cc	and,duplication
R2587	T4298	T4299	amod	subsequent,divergence
R2588	T4299	T4295	conj	divergence,duplication
R2589	T4300	T4295	prep	of,duplication
R2590	T4301	T4302	det	these,segments
R2591	T4302	T4300	pobj	segments,of
R2592	T4303	T4302	amod	paralogous,segments
R2593	T4304	T4302	amod	chromosomal,segments
R2594	T4305	T4295	punct	", ",duplication
R2595	T4306	T4295	acl	estimated,duplication
R2596	T4307	T4308	aux	to,occurred
R2597	T4308	T4306	xcomp	occurred,estimated
R2598	T4309	T4308	aux	have,occurred
R2599	T4310	T4311	quantmod	687,155.7
R2600	T4311	T4313	npadvmod	155.7,MYA
R2601	T4312	T4311	punct	±,155.7
R2602	T4313	T4308	advmod	MYA,occurred
R2603	T4314	T4280	punct	.,suggests
R2604	T4316	T4317	nsubj	This,raised
R2605	T4318	T4317	aux	has,raised
R2606	T4319	T4320	det	the,suggestion
R2607	T4320	T4317	dobj	suggestion,raised
R2608	T4321	T4322	mark	that,reside
R2609	T4322	T4320	acl	reside,suggestion
R2610	T4323	T4324	det	a,gene
R2611	T4324	T4322	nsubj	gene,reside
R2612	T4325	T4324	amod	fourth,gene
R2613	T4326	T4324	compound	TACC,gene
R2614	T4327	T4324	prep	in,gene
R2615	T4328	T4327	pobj	vertebrates,in
R2616	T4329	T4322	aux	would,reside
R2617	T4330	T4322	prep	in,reside
R2618	T4331	T4332	det	the,region
R2619	T4332	T4330	pobj	region,in
R2620	T4333	T4332	amod	same,region
R2621	T4334	T4332	amod	chromosomal,region
R2622	T4335	T4332	prep	as,region
R2623	T4336	T4335	pobj	FGFR4,as
R2624	T4337	T4317	punct	.,raised
R2625	T4339	T4340	advmod	Indeed,used
R2626	T4341	T4342	det	this,hypothesis
R2627	T4342	T4340	nsubjpass	hypothesis,used
R2628	T4343	T4340	aux	has,used
R2629	T4344	T4340	auxpass	been,used
R2630	T4345	T4340	prep	in,used
R2631	T4346	T4345	pobj	support,in
R2632	T4347	T4346	prep	for,support
R2633	T4348	T4349	det	the,gene
R2634	T4349	T4347	pobj	gene,for
R2635	T4350	T4349	compound	RHAMM,gene
R2636	T4351	T4349	prep	as,gene
R2637	T4352	T4353	det	a,member
R2638	T4353	T4351	pobj	member,as
R2639	T4354	T4353	prep	of,member
R2640	T4355	T4356	det	the,family
R2641	T4356	T4354	pobj	family,of
R2642	T4357	T4356	compound	TACC,family
R2643	T4358	T4359	punct	[,10
R2644	T4359	T4340	parataxis	10,used
R2645	T4360	T4359	punct	],10
R2646	T4361	T4340	punct	.,used
R2647	T4363	T4364	amod	Human,RHAMM
R2648	T4364	T4365	nsubj	RHAMM,maps
R2649	T4366	T4365	prep	to,maps
R2650	T4367	T4368	compound	chromosome,5q32
R2651	T4368	T4366	pobj	5q32,to
R2652	T4369	T4365	prep	in,maps
R2653	T4370	T4371	det	a,region
R2654	T4371	T4369	pobj	region,in
R2655	T4372	T4371	acl	bounded,region
R2656	T4373	T4372	agent	by,bounded
R2657	T4374	T4373	pobj	GPX3,by
R2658	T4375	T4374	cc	and,GPX3
R2659	T4376	T4374	conj	NKX2E,GPX3
R2660	T4377	T4365	punct	.,maps
R2661	T4379	T4380	det	These,loci
R2662	T4380	T4381	nsubj	loci,separate
R2663	T4382	T4383	nummod	two,clusters
R2664	T4383	T4381	dobj	clusters,separate
R2665	T4384	T4383	prep	of,clusters
R2666	T4385	T4384	pobj	genes,of
R2667	T4386	T4383	prep	on,clusters
R2668	T4387	T4388	amod	human,chromosome
R2669	T4388	T4386	pobj	chromosome,on
R2670	T4389	T4388	nummod	5,chromosome
R2671	T4390	T4391	dep	that,are
R2672	T4391	T4383	relcl	are,clusters
R2713	T4434	T4398	punct	.,located
R2715	T4438	T4446	advcl	provide,attempted
R2716	T4439	T4440	det	the,conservation
R2717	T4440	T4438	nsubj	conservation,provide
R2718	T4441	T4440	prep	of,conservation
R2719	T4442	T4443	compound	gene,order
R2720	T4443	T4441	pobj	order,of
R2721	T4444	T4438	aux	can,provide
R2722	T4445	T4438	advmod	also,provide
R2723	T4447	T4438	dobj	clues,provide
R2724	T4448	T4447	prep	to,clues
R2725	T4449	T4450	det	the,evolution
R2726	T4450	T4448	pobj	evolution,to
R2727	T4451	T4450	prep	of,evolution
R2728	T4452	T4453	compound	gene,regulation
R2729	T4453	T4451	pobj	regulation,of
R2730	T4454	T4446	punct	", ",attempted
R2731	T4455	T4446	nsubj	we,attempted
R2732	T4456	T4446	advmod	next,attempted
R2733	T4457	T4458	aux	to,trace
R2734	T4458	T4446	xcomp	trace,attempted
R2735	T4459	T4460	det	the,evolution
R2736	T4460	T4458	dobj	evolution,trace
R2737	T4461	T4460	prep	of,evolution
R2738	T4462	T4463	det	these,segments
R2739	T4463	T4461	pobj	segments,of
R2740	T4464	T4463	amod	paralogous,segments
R2741	T4465	T4458	prep	by,trace
R2742	T4466	T4465	pcomp	examining,by
R2743	T4467	T4468	det	the,genome
R2744	T4468	T4466	dobj	genome,examining
R2745	T4469	T4468	prep	of,genome
R2746	T4470	T4471	det	the,tunicate
R2747	T4471	T4469	pobj	tunicate,of
R2748	T4472	T4473	compound	C.,intestinalis
R2749	T4473	T4471	appos	intestinalis,tunicate
R2750	T4474	T4475	punct	[,11
R2751	T4475	T4471	parataxis	11,tunicate
R2752	T4476	T4475	punct	],11
R2753	T4477	T4468	cc	and,genome
R2754	T4478	T4479	det	the,genome
R2755	T4479	T4468	conj	genome,genome
R2756	T4480	T4481	amod	most,primitive
R2757	T4481	T4479	amod	primitive,genome
R2758	T4482	T4481	punct	"""",primitive
R2759	T4483	T4481	punct	"""",primitive
R2760	T4484	T4479	amod	compact,genome
R2761	T4485	T4479	compound	vertebrate,genome
R2762	T4486	T4479	acl	sequenced,genome
R2763	T4487	T4486	prep	to,sequenced
R2764	T4488	T4487	pobj	date,to
R2765	T4489	T4479	punct	", ",genome
R2766	T4490	T4491	compound	T.,rubripes
R2767	T4491	T4479	appos	rubripes,genome
R2768	T4492	T4493	punct	[,14
R2769	T4493	T4479	parataxis	14,genome
R2770	T4494	T4493	punct	],14
R2771	T4495	T4446	punct	.,attempted
R2772	T4497	T4498	mark	Although,assembled
R2773	T4498	T4501	advcl	assembled,confirmed
R2774	T4499	T4498	neg	not,assembled
R2775	T4500	T4498	advmod	fully,assembled
R2776	T4502	T4501	punct	", ",confirmed
R2777	T4503	T4501	nsubj	examination,confirmed
R2778	T4504	T4503	prep	of,examination
R2779	T4505	T4506	det	the,genome
R2780	T4506	T4504	pobj	genome,of
R2781	T4507	T4506	prep	of,genome
R2782	T4508	T4509	compound	T.,rubripes
R2783	T4509	T4507	pobj	rubripes,of
R2784	T4510	T4511	det	the,presence
R2785	T4511	T4501	dobj	presence,confirmed
R2786	T4512	T4511	prep	of,presence
R2787	T4513	T4514	amod	chromosomal,segments
R2788	T4514	T4512	pobj	segments,of
R2789	T4515	T4514	amod	paralogous,segments
R2790	T4516	T4515	prep	to,paralogous
R2791	T4517	T4516	pobj	those,to
R2792	T4518	T4517	acl	found,those
R2793	T4519	T4518	prep	in,found
R2794	T4520	T4521	amod	higher,vertebrates
R2795	T4521	T4519	pobj	vertebrates,in
R2796	T4522	T4523	punct	(,Fig.
R2797	T4523	T4501	parataxis	Fig.,confirmed
R2798	T4524	T4523	nummod	2,Fig.
R2799	T4525	T4523	punct	),Fig.
R2800	T4526	T4501	punct	.,confirmed
R2801	T4528	T4529	prep	For,found
R2802	T4530	T4528	pobj	instance,For
R2803	T4531	T4529	punct	", ",found
R2804	T4532	T4533	det	the,orthologues
R2805	T4533	T4529	nsubjpass	orthologues,found
R2806	T4534	T4533	prep	of,orthologues
R2807	T4535	T4534	pobj	GPRK2L,of
R2808	T4536	T4535	cc	and,GPRK2L
R2809	T4537	T4535	conj	RGS12,GPRK2L
R2810	T4538	T4529	auxpass	are,found
R2811	T4539	T4529	prep	on,found
R2812	T4540	T4541	compound	T.,rubripes
R2813	T4541	T4542	compound	rubripes,scaffold
R2814	T4542	T4539	pobj	scaffold,on
R2815	T4543	T4542	nummod	290,scaffold
R2816	T4544	T4542	punct	(,scaffold
R2817	T4545	T4542	appos	emb\|CAAB01000290.1,scaffold
R2818	T4546	T4542	punct	),scaffold
R2819	T4547	T4539	punct	", ",on
R2820	T4548	T4539	cc	and,on
R2821	T4549	T4539	conj	within,on
R2822	T4550	T4551	nummod	300,kb
R2823	T4551	T4549	pobj	kb,within
R2824	T4552	T4551	prep	of,kb
R2825	T4553	T4554	det	each,other
R2826	T4554	T4552	pobj	other,of
R2827	T4555	T4551	prep	in,kb
R2828	T4556	T4557	amod	human,4p16
R2829	T4557	T4555	pobj	4p16,in
R2830	T4558	T4529	punct	.,found
R2831	T4560	T4561	det	The,orthologues
R2832	T4561	T4564	nsubjpass	orthologues,located
R2833	T4562	T4563	compound	T.,rubripes
R2834	T4563	T4561	compound	rubripes,orthologues
R2835	T4565	T4561	prep	of,orthologues
R2836	T4566	T4565	pobj	FGFR3,of
R2837	T4567	T4561	punct	", ",orthologues
R2838	T4568	T4561	appos	LETM1,orthologues
R2839	T4569	T4568	cc	and,LETM1
R2840	T4570	T4568	conj	WHSC1,LETM1
R2841	T4571	T4564	auxpass	are,located
R2842	T4572	T4564	prep	on,located
R2843	T4573	T4574	det	the,scaffold
R2844	T4574	T4572	pobj	scaffold,on
R2845	T4575	T4574	amod	same,scaffold
R2846	T4576	T4577	nummod	166,kb
R2847	T4577	T4574	nmod	kb,scaffold
R2848	T4578	T4574	amod	genomic,scaffold
R2849	T4579	T4574	nummod	251,scaffold
R2850	T4580	T4574	punct	(,scaffold
R2851	T4581	T4574	appos	emb\|CAAB01000166.1,scaffold
R2852	T4582	T4574	punct	),scaffold
R2853	T4583	T4564	punct	.,located
R2854	T4585	T4586	advmod	Significantly,located
R2855	T4587	T4586	punct	", ",located
R2856	T4588	T4589	det	the,orthologues
R2857	T4589	T4586	nsubjpass	orthologues,located
R2858	T4590	T4589	nummod	three,orthologues
R2859	T4591	T4589	amod	human,orthologues
R2860	T4592	T4589	prep	of,orthologues
R2861	T4593	T4594	det	these,genes
R2862	T4594	T4592	pobj	genes,of
R2863	T4595	T4586	auxpass	are,located
R2864	T4596	T4586	advmod	also,located
R2865	T4597	T4586	prep	within,located
R2866	T4598	T4599	nummod	300,kb
R2867	T4599	T4597	pobj	kb,within
R2868	T4600	T4599	prep	of,kb
R2869	T4601	T4602	det	each,other
R2870	T4602	T4600	pobj	other,of
R2871	T4603	T4586	prep	on,located
R2872	T4604	T4603	pobj	4p16,on
R2873	T4605	T4586	punct	.,located
R2874	T4607	T4608	advmod	Furthermore,map
R2875	T4609	T4608	punct	", ",map
R2876	T4610	T4608	nsubj	TACC3,map
R2877	T4611	T4610	cc	and,TACC3
R2878	T4612	T4610	conj	FGFRL,TACC3
R2879	T4613	T4608	prep	to,map
R2880	T4614	T4615	det	the,scaffolds
R2881	T4615	T4613	pobj	scaffolds,to
R2882	T4616	T4615	amod	overlapping,scaffolds
R2883	T4617	T4618	nummod	1184,4669
R2884	T4618	T4615	appos	4669,scaffolds
R2885	T4619	T4618	punct	/,4669
R2886	T4620	T4618	punct	(,4669
R2887	T4621	T4618	appos	emb\|CAAB01004668,4669
R2888	T4622	T4618	punct	),4669
R2889	T4623	T4608	punct	.,map
R2890	T4625	T4626	advmod	Similarly,found
R2891	T4627	T4626	punct	", ",found
R2892	T4628	T4626	nsubjpass	elements,found
R2893	T4629	T4628	prep	of,elements
R2894	T4630	T4631	det	these,clusters
R2895	T4631	T4629	pobj	clusters,of
R2896	T4632	T4631	compound	gene,clusters
R2897	T4633	T4628	punct	", ",elements
R2898	T4634	T4628	acl	extending,elements
R2899	T4635	T4634	prep	from,extending
R2900	T4636	T4635	pobj	HMP19,from
R2901	T4637	T4634	prep	to,extending
R2902	T4638	T4637	pobj	GPRK6,to
R2903	T4639	T4634	prep	in,extending
R2904	T4640	T4641	amod	human,chromosome
R2905	T4641	T4642	compound	chromosome,ter
R2906	T4642	T4639	pobj	ter,in
R2907	T4643	T4642	compound	5q34,ter
R2908	T4644	T4642	punct	-,ter
R2909	T4645	T4626	auxpass	are,found
R2910	T4646	T4626	advmod	also,found
R2911	T4647	T4626	prep	in,found
R2912	T4648	T4649	det	the,pufferfish
R2913	T4649	T4647	pobj	pufferfish,in
R2914	T4650	T4626	punct	", ",found
R2915	T4651	T4626	prep	with,found
R2916	T4652	T4653	det	the,orthologues
R2917	T4653	T4651	pobj	orthologues,with
R2918	T4654	T4655	compound	T.,rubripes
R2919	T4655	T4653	compound	rubripes,orthologues
R2920	T4656	T4653	prep	of,orthologues
R2921	T4657	T4656	pobj	NSD1,of
R2922	T4658	T4653	punct	", ",orthologues
R2923	T4659	T4653	appos	FGFR4,orthologues
R2924	T4660	T4653	cc	and,orthologues
R2925	T4661	T4662	advmod	a,like
R2926	T4662	T4665	amod	like,mapping
R2927	T4663	T4662	npadvmod	RAB,like
R2928	T4664	T4662	punct	-,like
R2929	T4665	T4653	conj	mapping,orthologues
R2930	T4666	T4665	compound	gene,mapping
R2931	T4667	T4653	prep	on,orthologues
R2932	T4668	T4667	pobj	scaffold,on
R2933	T4669	T4668	nummod	407,scaffold
R2934	T4670	T4668	punct	(,scaffold
R2935	T4671	T4668	appos	emb\|CAAB01000407,scaffold
R2936	T4672	T4668	punct	),scaffold
R2937	T4673	T4626	punct	.,found
R2938	T4675	T4676	advmod	However,is
R2939	T4677	T4676	punct	", ",is
R2940	T4678	T4676	expl	there,is
R2941	T4679	T4680	det	no,evidence
R2942	T4680	T4676	attr	evidence,is
R2943	T4681	T4680	prep	for,evidence
R2944	T4682	T4683	det	a,gene
R2945	T4683	T4681	pobj	gene,for
R2946	T4684	T4683	acl	corresponding,gene
R2947	T4685	T4684	prep	to,corresponding
R2948	T4686	T4687	det	a,gene
R2949	T4687	T4685	pobj	gene,to
R2950	T4688	T4687	compound	TACC4,gene
R2951	T4689	T4676	prep	in,is
R2952	T4690	T4689	pobj	any,in
R2953	T4691	T4690	prep	of,any
R2954	T4692	T4693	det	these,clusters
R2955	T4693	T4691	pobj	clusters,of
R2956	T4694	T4676	punct	.,is
R2957	T4696	T4697	mark	As,noted
R2958	T4697	T4698	advcl	noted,indicate
R2959	T4699	T4697	advmod	above,noted
R2960	T4700	T4698	punct	", ",indicate
R2961	T4701	T4702	amod	phylogenetic,analysis
R2962	T4702	T4698	nsubj	analysis,indicate
R2963	T4703	T4702	prep	of,analysis
R2964	T4704	T4705	det	the,sequences
R2965	T4705	T4703	pobj	sequences,of
R2966	T4706	T4705	compound	TACC,sequences
R2967	T4707	T4708	mark	that,are
R2968	T4708	T4698	ccomp	are,indicate
R2969	T4709	T4708	expl	there,are
R2970	T4710	T4711	nummod	two,genes
R2971	T4711	T4708	attr	genes,are
R2972	T4712	T4713	npadvmod	TACC1,related
R2973	T4713	T4711	amod	related,genes
R2974	T4714	T4708	prep	in,are
R2975	T4715	T4716	det	the,pufferfish
R2976	T4716	T4714	pobj	pufferfish,in
R2977	T4717	T4698	punct	.,indicate
R2978	T4719	T4720	nsubjpass	trTACC1B,located
R2979	T4721	T4720	auxpass	is,located
R2980	T4722	T4720	prep	on,located
R2981	T4723	T4724	det	the,scaffold
R2982	T4724	T4722	pobj	scaffold,on
R2983	T4725	T4726	nummod	180,kb
R2984	T4726	T4724	compound	kb,scaffold
R2985	T4727	T4724	nummod	191,scaffold
R2986	T4728	T4724	punct	(,scaffold
R2987	T4729	T4724	appos	emb\|CAAB01000191.1,scaffold
R2988	T4730	T4724	punct	),scaffold
R2989	T4731	T4724	punct	", ",scaffold
R2990	T4732	T4733	dep	which,contains
R2991	T4733	T4724	relcl	contains,scaffold
R2992	T4734	T4733	advmod	also,contains
R2993	T4735	T4736	det	the,orthologues
R2994	T4736	T4733	dobj	orthologues,contains
R2995	T4737	T4736	prep	of,orthologues
R2996	T4738	T4739	amod	several,genes
R2997	T4739	T4737	pobj	genes,of
R2998	T4740	T4739	acl	located,genes
R2999	T4741	T4740	prep	in,located
R3000	T4742	T4743	amod	human,8p21
R3001	T4743	T4741	pobj	8p21,in
R3002	T4744	T4743	compound	chromosome,8p21
R3003	T4745	T4743	punct	-,8p21
R3004	T4746	T4743	nummod	11,8p21
R3005	T4747	T4720	punct	.,located
R3006	T4749	T4750	advmod	Thus,represents
R3007	T4751	T4750	punct	", ",represents
R3008	T4752	T4753	det	this,scaffold
R3009	T4753	T4750	nsubj	scaffold,represents
R3010	T4754	T4755	det	the,segment
R3011	T4755	T4750	dobj	segment,represents
R3012	T4756	T4757	advmod	more,developed
R3013	T4757	T4755	amod	developed,segment
R3014	T4758	T4757	punct	"""",developed
R3015	T4759	T4757	punct	"""",developed
R3016	T4760	T4755	nmod	TACC1,segment
R3017	T4761	T4755	amod	chromosomal,segment
R3018	T4762	T4763	dep	that,is
R3019	T4763	T4755	relcl	is,segment
R3020	T4764	T4763	acomp	evident,is
R3021	T4765	T4763	prep	in,is
R3022	T4766	T4767	amod	higher,vertebrates
R3023	T4767	T4765	pobj	vertebrates,in
R3024	T4768	T4750	punct	.,represents
R3025	T4770	T4771	prep	On,located
R3026	T4772	T4773	det	the,hand
R3027	T4773	T4770	pobj	hand,On
R3028	T4774	T4773	amod	other,hand
R3029	T4775	T4771	punct	", ",located
R3030	T4776	T4777	det	the,gene
R3031	T4777	T4771	nsubjpass	gene,located
R3032	T4778	T4777	compound	trTACC1A,gene
R3033	T4779	T4771	auxpass	is,located
R3034	T4780	T4771	prep	in,located
R3035	T4781	T4782	det	the,scaffold
R3036	T4782	T4780	pobj	scaffold,in
R3037	T4783	T4784	nummod	396,kb
R3038	T4784	T4782	compound	kb,scaffold
R3039	T4785	T4782	nummod	12,scaffold
R3040	T4786	T4782	punct	(,scaffold
R3041	T4787	T4782	appos	emb\|CAAB010012.1,scaffold
R3042	T4788	T4782	punct	),scaffold
R3043	T4789	T4771	punct	.,located
R3044	T4791	T4792	det	This,scaffold
R3045	T4792	T4793	nsubj	scaffold,contains
R3046	T4794	T4793	advmod	also,contains
R3047	T4795	T4796	det	the,orthologues
R3048	T4796	T4793	dobj	orthologues,contains
R3049	T4797	T4798	compound	T.,rubripes
R3050	T4798	T4796	compound	rubripes,orthologues
R3051	T4799	T4796	prep	of,orthologues
R3052	T4800	T4799	pobj	MSX1,of
R3053	T4801	T4800	punct	", ",MSX1
R3054	T4802	T4800	conj	STX18,MSX1
R3055	T4803	T4802	punct	", ",STX18
R3056	T4804	T4802	conj	D4S234E,STX18
R3057	T4805	T4804	cc	and,D4S234E
R3058	T4806	T4807	det	the,gene
R3059	T4807	T4804	conj	gene,D4S234E
R3060	T4808	T4807	amod	predicted,gene
R3061	T4809	T4807	appos	LOC118711,gene
R3062	T4810	T4793	punct	", ",contains
R3063	T4811	T4793	prep	in,contains
R3064	T4812	T4811	pobj	addition,in
R3065	T4813	T4812	prep	to,addition
R3066	T4814	T4813	pobj	sequences,to
R3067	T4815	T4814	prep	with,sequences
R3068	T4816	T4815	pobj	homology,with
R3069	T4817	T4816	prep	to,homology
R3070	T4818	T4817	pobj	LOXL,to
R3071	T4819	T4818	punct	", ",LOXL
R3072	T4820	T4818	conj	EVC,LOXL
R3073	T4821	T4820	punct	", ",EVC
R3074	T4822	T4820	conj	LOC159291,EVC
R3075	T4823	T4822	punct	", ",LOC159291
R3076	T4824	T4822	cc	and,LOC159291
R3077	T4825	T4826	det	the,family
R3078	T4826	T4822	conj	family,LOC159291
R3079	T4827	T4826	compound	LDB,family
R3080	T4828	T4793	punct	.,contains
R3081	T4830	T4831	advmod	Thus,contains
R3082	T4832	T4831	punct	", ",contains
R3083	T4833	T4831	nsubj	scaffold,contains
R3084	T4834	T4833	nummod	12,scaffold
R3085	T4835	T4831	dobj	genes,contains
R3086	T4836	T4835	acl	found,genes
R3087	T4837	T4836	prep	in,found
R3088	T4838	T4839	det	the,regions
R3089	T4839	T4837	pobj	regions,in
R3090	T4840	T4839	prep	of,regions
R3091	T4841	T4842	amod	human,4
R3092	T4842	T4840	pobj	4,of
R3093	T4843	T4842	nmod	chromosome,4
R3094	T4844	T4842	cc	and,4
R3095	T4845	T4842	conj	10,4
R3096	T4846	T4847	dep	that,contain
R3097	T4847	T4835	relcl	contain,genes
R3098	T4848	T4847	advmod	also,contain
R3099	T4849	T4850	det	the,loci
R3100	T4850	T4847	dobj	loci,contain
R3101	T4851	T4850	prep	for,loci
R3102	T4852	T4851	pobj	TACC3,for
R3103	T4853	T4852	cc	and,TACC3
R3104	T4854	T4852	conj	TACC2,TACC3
R3105	T4855	T4847	punct	", ",contain
R3106	T4856	T4847	advmod	respectively,contain
R3107	T4857	T4831	punct	", ",contains
R3108	T4858	T4831	cc	and,contains
R3109	T4859	T4860	aux	may,resemble
R3110	T4860	T4831	conj	resemble,contains
R3111	T4861	T4860	advmod	therefore,resemble
R3112	T4862	T4863	advmod	more,closely
R3113	T4863	T4860	advmod	closely,resemble
R3114	T4864	T4865	det	the,organization
R3115	T4865	T4860	dobj	organization,resemble
R3116	T4866	T4865	amod	genomic,organization
R3117	T4867	T4865	acl	resulting,organization
R3118	T4868	T4867	prep	from,resulting
R3119	T4869	T4870	det	the,duplication
R3120	T4870	T4868	pobj	duplication,from
R3121	T4871	T4870	amod	initial,duplication
R3122	T4872	T4870	prep	of,duplication
R3123	T4873	T4874	det	the,segment
R3124	T4874	T4872	pobj	segment,of
R3125	T4875	T4874	amod	ancestral,segment
R3126	T4876	T4874	amod	paralogous,segment
R3127	T4877	T4874	amod	chromosomal,segment
R3128	T4878	T4831	punct	.,contains
R3129	T4880	T4881	amod	Conserved,clusters
R3130	T4881	T4883	nsubj	clusters,result
R3131	T4882	T4881	amod	paralogous,clusters
R3132	T4884	T4883	aux	may,result
R3133	T4885	T4883	prep	from,result
R3134	T4886	T4887	det	the,clustering
R3135	T4887	T4885	pobj	clustering,from
R3136	T4888	T4887	amod	initial,clustering
R3137	T4889	T4887	prep	of,clustering
R3138	T4890	T4891	det	the,genes
R3139	T4891	T4889	pobj	genes,of
R3140	T4892	T4887	prep	in,clustering
R3141	T4893	T4894	det	a,contig
R3142	T4894	T4892	pobj	contig,in
R3143	T4895	T4896	advmod	relatively,small
R3144	T4896	T4894	amod	small,contig
R3145	T4897	T4894	amod	ancestral,contig
R3146	T4898	T4894	amod	genomic,contig
R3147	T4899	T4883	punct	.,result
R3148	T4901	T4902	det	Some,evidence
R3149	T4902	T4903	nsubj	evidence,is
R3150	T4904	T4902	prep	for,evidence
R3151	T4905	T4906	det	the,existence
R3152	T4906	T4904	pobj	existence,for
R3153	T4907	T4906	prep	of,existence
R3154	T4908	T4909	punct	"""",protoclusters
R3155	T4909	T4907	pobj	protoclusters,of
R3156	T4910	T4909	punct	"""",protoclusters
R3157	T4911	T4912	dep	that,correspond
R3158	T4912	T4909	relcl	correspond,protoclusters
R3159	T4913	T4912	aux	could,correspond
R3160	T4914	T4912	prep	to,correspond
R3161	T4915	T4916	det	the,segments
R3162	T4916	T4914	pobj	segments,to
R3163	T4917	T4916	amod	paralogous,segments
R3164	T4918	T4916	amod	chromosomal,segments
R3165	T4919	T4916	acl	noted,segments
R3166	T4920	T4919	prep	in,noted
R3167	T4921	T4922	amod	higher,vertebrates
R3168	T4922	T4920	pobj	vertebrates,in
R3169	T4923	T4903	acomp	present,is
R3170	T4924	T4903	prep	in,is
R3171	T4925	T4926	det	the,genome
R3172	T4926	T4924	pobj	genome,in
R3173	T4927	T4926	prep	of,genome
R3174	T4928	T4929	det	the,urochordate
R3175	T4929	T4927	pobj	urochordate,of
R3176	T4930	T4931	compound	C.,intestinalis
R3177	T4931	T4929	appos	intestinalis,urochordate
R3178	T4932	T4933	punct	[,11
R3179	T4933	T4903	parataxis	11,is
R3180	T4934	T4933	punct	],11
R3181	T4935	T4903	punct	.,is
R3182	T4937	T4938	prep	For,cluster
R3183	T4939	T4937	pobj	instance,For
R3184	T4940	T4938	punct	", ",cluster
R3185	T4941	T4942	det	the,orthologues
R3186	T4942	T4938	nsubj	orthologues,cluster
R3187	T4943	T4942	prep	of,orthologues
R3188	T4944	T4943	pobj	FGFR,of
R3189	T4945	T4944	punct	", ",FGFR
R3190	T4946	T4944	cc	and,FGFR
R3191	T4947	T4944	conj	WHSC1,FGFR
R3192	T4948	T4942	punct	", ",orthologues
R3193	T4949	T4950	compound	carboxypeptidase,Z
R3194	T4950	T4942	appos	Z,orthologues
R3195	T4951	T4950	cc	and,Z
R3196	T4952	T4950	conj	FLJ25359,Z
R3197	T4953	T4938	prep	within,cluster
R3198	T4954	T4955	det	an,region
R3199	T4955	T4953	pobj	region,within
R3200	T4956	T4957	nummod	85,kb
R3201	T4957	T4955	compound	kb,region
R3202	T4958	T4955	prep	of,region
R3203	T4959	T4960	det	the,genome
R3204	T4960	T4958	pobj	genome,of
R3205	T4961	T4962	compound	C.,intestinalis
R3206	T4962	T4960	compound	intestinalis,genome
R3207	T4963	T4938	cc	and,cluster
R3208	T4964	T4965	det	the,orthologues
R3209	T4965	T4967	nsubjpass	orthologues,maintained
R3210	T4966	T4965	amod	human,orthologues
R3211	T4967	T4938	conj	maintained,cluster
R3212	T4968	T4967	auxpass	are,maintained
R3213	T4969	T4967	advmod	still,maintained
R3214	T4970	T4967	prep	in,maintained
R3215	T4971	T4972	amod	paralogous,segments
R3216	T4972	T4970	pobj	segments,in
R3217	T4973	T4972	prep	of,segments
R3218	T4974	T4973	pobj	4p16,of
R3219	T4975	T4974	punct	", ",4p16
R3220	T4976	T4974	conj	8p,4p16
R3221	T4977	T4976	cc	and,8p
R3222	T4978	T4976	conj	10q,8p
R3223	T4979	T4980	punct	(,Fig.
R3224	T4980	T4967	parataxis	Fig.,maintained
R3225	T4981	T4980	nummod	3,Fig.
R3226	T4982	T4980	punct	", ",Fig.
R3227	T4983	T4980	punct	[,Fig.
R3228	T4984	T4980	advcl	see,Fig.
R3229	T4985	T4986	amod	Additional,file
R3230	T4986	T4984	dobj	file,see
R3231	T4987	T4986	nummod	1,file
R3232	T4988	T4980	punct	],Fig.
R3233	T4989	T4980	punct	),Fig.
R3234	T4990	T4938	punct	.,cluster
R3235	T4992	T4993	advmod	However,noted
R3236	T4994	T4993	punct	", ",noted
R3237	T4995	T4993	nsubjpass	it,noted
R3238	T4996	T4993	aux	should,noted
R3239	T4997	T4993	auxpass	be,noted
R3240	T4998	T4999	mark	that,locate
R3241	T4999	T4993	ccomp	locate,noted
R3242	T5000	T5001	det	no,clusters
R3243	T5001	T4999	nsubjpass	clusters,locate
R3244	T5002	T5001	prep	of,clusters
R3245	T5003	T5002	pobj	genes,of
R3246	T5004	T5003	prep	from,genes
R3247	T5005	T5006	det	the,segments
R3248	T5006	T5004	pobj	segments,from
R3249	T5007	T5006	nmod	vertebrate,segments
R3250	T5008	T5006	amod	paralogous,segments
R3251	T5009	T4999	auxpass	are,locate
R3252	T5010	T4999	advmod	close,locate
R3253	T5011	T5010	prep	to,close
R3254	T5012	T5013	det	the,genes
R3255	T5013	T5011	pobj	genes,to
R3256	T5014	T5013	nmod	TACC,genes
R3257	T5015	T5014	cc	or,TACC
R3258	T5016	T5014	conj	RHAMM,TACC
R3259	T5017	T5013	prep	of,genes
R3260	T5018	T5019	compound	C.,intestinalis
R3261	T5019	T5017	pobj	intestinalis,of
R3262	T5020	T4999	punct	", ",locate
R3263	T5021	T4999	advcl	indicating,locate
R3264	T5022	T5023	mark	that,formed
R3265	T5023	T5021	ccomp	formed,indicating
R3266	T5024	T5025	det	the,formation
R3267	T5025	T5023	nsubj	formation,formed
R3268	T5026	T5025	prep	of,formation
R3269	T5027	T5028	det	the,segments
R3270	T5028	T5026	pobj	segments,of
R3271	T5029	T5030	advmod	much,larger
R3272	T5030	T5028	amod	larger,segments
R3273	T5031	T5028	amod	paralogous,segments
R3274	T5032	T5028	acl	encompassing,segments
R3275	T5033	T5034	det	the,genes
R3276	T5034	T5032	dobj	genes,encompassing
R3277	T5035	T5036	compound	FGFR,TACC
R3278	T5036	T5034	compound	TACC,genes
R3279	T5037	T5036	punct	-,TACC
R3280	T5038	T5023	advmod	later,formed
R3281	T5039	T5038	prep	in,later
R3282	T5040	T5041	amod	evolutionary,time
R3283	T5041	T5039	pobj	time,in
R3284	T5042	T5023	punct	", ",formed
R3285	T5043	T5023	cc	or,formed
R3286	T5044	T5045	advmod	conversely,been
R3287	T5045	T5023	conj	been,formed
R3288	T5046	T5045	aux	have,been
R3289	T5047	T5045	acomp	subject,been
R3290	T5048	T5047	prep	to,subject
R3291	T5049	T5050	amod	extensive,rearrangement
R3292	T5050	T5048	pobj	rearrangement,to
R3293	T5051	T5045	prep	in,been
R3294	T5052	T5051	pobj	tunicates,in
R3295	T5053	T4993	punct	.,noted
R3296	T5055	T5056	prep	In,provides
R3297	T5057	T5055	pobj	combination,In
R3298	T5058	T5057	prep	with,combination
R3299	T5059	T5060	det	the,examination
R3300	T5060	T5058	pobj	examination,with
R3301	T5061	T5060	prep	of,examination
R3302	T5062	T5063	det	the,genome
R3303	T5063	T5061	pobj	genome,of
R3304	T5064	T5065	compound	T.,rubripes
R3305	T5065	T5063	compound	rubripes,genome
R3306	T5066	T5056	punct	", ",provides
R3307	T5067	T5056	nsubj	this,provides
R3308	T5068	T5056	advmod	also,provides
R3309	T5069	T5070	amod	additional,evidence
R3310	T5070	T5056	dobj	evidence,provides
R3311	T5071	T5072	mark	that,include
R3312	T5072	T5070	advcl	include,evidence
R3313	T5073	T5072	preconj	either,include
R3314	T5074	T5075	det	the,round
R3315	T5075	T5072	nsubj	round,include
R3316	T5076	T5075	amod	second,round
R3317	T5077	T5075	prep	of,round
R3318	T5078	T5077	pobj	duplication,of
R3319	T5079	T5078	prep	of,duplication
R3320	T5080	T5081	det	the,segment
R3321	T5081	T5079	pobj	segment,of
R3322	T5082	T5081	amod	chromosomal,segment
R3323	T5083	T5084	dep	that,contained
R3324	T5084	T5081	relcl	contained,segment
R3325	T5085	T5086	det	the,ancestor
R3326	T5086	T5084	dobj	ancestor,contained
R3327	T5087	T5086	nmod	FGFR3,ancestor
R3328	T5088	T5087	punct	/,FGFR3
R3329	T5089	T5087	nummod	4,FGFR3
R3330	T5090	T5072	aux	did,include
R3331	T5091	T5072	neg	not,include
R3332	T5092	T5093	det	a,gene
R3333	T5093	T5072	dobj	gene,include
R3334	T5094	T5093	compound	TACC,gene
R3335	T5095	T5072	punct	", ",include
R3336	T5096	T5072	cc	or,include
R3337	T5097	T5098	mark	that,lost
R3338	T5098	T5072	conj	lost,include
R3339	T5099	T5100	predet	such,gene
R3340	T5100	T5098	nsubjpass	gene,lost
R3341	T5101	T5100	det	a,gene
R3342	T5102	T5098	auxpass	was,lost
R3343	T5103	T5104	advmod	very,early
R3344	T5104	T5098	advmod	early,lost
R3345	T5105	T5104	prep	in,early
R3346	T5106	T5107	compound	vertebrate,evolution
R3347	T5107	T5105	pobj	evolution,in
R3348	T5108	T5098	punct	", ",lost
R3349	T5109	T5098	advmod	prior,lost
R3350	T5110	T5109	prep	to,prior
R3351	T5111	T5112	det	the,divergence
R3352	T5112	T5110	pobj	divergence,to
R3353	T5113	T5112	prep	of,divergence
R3354	T5114	T5115	det	the,lineages
R3355	T5115	T5113	pobj	lineages,of
R3356	T5116	T5115	compound	Gnanthostome,lineages
R3357	T5117	T5056	punct	.,provides
R3358	T5119	T5120	advmod	However,await
R3359	T5121	T5120	punct	", ",await
R3360	T5122	T5123	det	the,resolution
R3361	T5123	T5120	nsubj	resolution,await
R3362	T5124	T5123	amod	final,resolution
R3398	T5160	T5159	amod	other,genes
R3399	T5161	T5159	amod	corresponding,genes
R3400	T5162	T5152	prep	in,contain
R3401	T5163	T5164	det	this,segment
R3402	T5164	T5162	pobj	segment,in
R3403	T5165	T5164	amod	conserved,segment
R3404	T5166	T5120	punct	.,await
R3405	T5507	T5508	amod	Comparative,structure
R3406	T5509	T5508	amod	genomic,structure
R3407	T5510	T5508	prep	of,structure
R3408	T5511	T5512	det	the,family
R3409	T5512	T5510	pobj	family,of
R3410	T5513	T5512	compound	TACC,family
R3411	T5515	T5516	det	The,sequences
R3412	T5516	T5519	nsubj	sequences,extracted
R3413	T5517	T5516	amod	genomic,sequences
R3414	T5518	T5516	compound	DNA,sequences
R3415	T5520	T5516	acl	corresponding,sequences
R3416	T5521	T5520	prep	to,corresponding
R3417	T5522	T5523	det	the,genes
R3418	T5523	T5521	pobj	genes,to
R3419	T5524	T5523	amod	orthologous,genes
R3420	T5525	T5523	compound	TACC,genes
R3421	T5526	T5523	prep	of,genes
R3422	T5527	T5526	pobj	human,of
R3423	T5528	T5527	punct	", ",human
R3424	T5529	T5527	conj	mouse,human
R3425	T5530	T5529	punct	", ",mouse
R3426	T5531	T5529	conj	rat,mouse
R3427	T5532	T5531	punct	", ",rat
R3428	T5533	T5531	conj	pufferfish,rat
R3429	T5534	T5533	punct	", ",pufferfish
R3430	T5535	T5536	compound	C.,intestinalis
R3431	T5536	T5533	conj	intestinalis,pufferfish
R3432	T5537	T5536	punct	", ",intestinalis
R3433	T5538	T5539	compound	D.,melanogaster
R3434	T5539	T5536	conj	melanogaster,intestinalis
R3435	T5540	T5539	cc	and,melanogaster
R3436	T5541	T5542	compound	C.,elegans
R3437	T5542	T5539	conj	elegans,melanogaster
R3438	T5543	T5519	aux	were,extracted
R3439	T5544	T5519	cc	and,extracted
R3440	T5545	T5519	conj	analyzed,extracted
R3441	T5546	T5545	prep	by,analyzed
R3442	T5547	T5546	pobj	Genescan,by
R3443	T5548	T5547	cc	and,Genescan
R3444	T5549	T5547	conj	BLAST,Genescan
R3445	T5550	T5551	aux	to,determine
R3446	T5551	T5519	advcl	determine,extracted
R3447	T5552	T5553	det	the,structure
R3448	T5553	T5551	dobj	structure,determine
R3449	T5554	T5553	amod	genomic,structure
R3450	T5555	T5553	prep	of,structure
R3451	T5556	T5557	det	each,gene
R3452	T5557	T5555	pobj	gene,of
R3453	T5558	T5557	compound	TACC,gene
R3454	T5559	T5519	punct	.,extracted
R3455	T5561	T5562	prep	In,added
R3456	T5563	T5564	det	some,cases
R3457	T5564	T5561	pobj	cases,In
R3458	T5565	T5562	punct	", ",added
R3459	T5566	T5562	prep	for,added
R3460	T5567	T5566	pobj	rat,for
R3461	T5568	T5567	cc	and,rat
R3462	T5569	T5567	conj	pufferfish,rat
R3463	T5570	T5562	punct	", ",added
R3464	T5571	T5562	nsubjpass	exons,added
R3465	T5572	T5562	auxpass	were,added
R3466	T5573	T5562	cc	or,added
R3467	T5574	T5562	conj	modified,added
R3468	T5575	T5574	prep	based,modified
R3469	T5576	T5575	prep	on,based
R3470	T5577	T5578	det	the,similarity
R3471	T5578	T5576	pobj	similarity,on
R3472	T5579	T5578	amod	best,similarity
R3473	T5580	T5578	prep	of,similarity
R3474	T5581	T5582	amod	translated,peptides
R3475	T5582	T5580	pobj	peptides,of
R3476	T5583	T5578	prep	to,similarity
R3477	T5584	T5585	det	the,proteins
R3478	T5585	T5583	pobj	proteins,to
R3479	T5586	T5585	amod	corresponding,proteins
R3480	T5587	T5585	nmod	mouse,proteins
R3481	T5588	T5587	cc	and,mouse
R3482	T5589	T5587	conj	human,mouse
R3483	T5590	T5562	punct	.,added
R3484	T5592	T5593	prep	For,used
R3485	T5594	T5592	pobj	regions,For
R3486	T5595	T5594	prep	with,regions
R3487	T5596	T5597	amod	low,similarity
R3488	T5597	T5595	pobj	similarity,with
R3489	T5598	T5597	compound	sequence,similarity
R3490	T5599	T5594	prep	in,regions
R3491	T5600	T5601	compound	T.,rubripes
R3492	T5601	T5599	pobj	rubripes,in
R3493	T5602	T5593	punct	", ",used
R3494	T5603	T5604	amod	genomic,sequences
R3495	T5604	T5593	nsubjpass	sequences,used
R3496	T5605	T5604	prep	from,sequences
R3497	T5606	T5607	det	the,pufferfish
R3498	T5607	T5605	pobj	pufferfish,from
R3499	T5608	T5609	amod	fresh,water
R3500	T5609	T5607	compound	water,pufferfish
R3501	T5610	T5607	punct	", ",pufferfish
R3502	T5611	T5612	compound	Tetraodon,nigroviridis
R3503	T5612	T5607	appos	nigroviridis,pufferfish
R3504	T5613	T5593	auxpass	were,used
R3505	T5614	T5593	prep	as,used
R3506	T5615	T5616	amod	additional,means
R3507	T5616	T5614	pobj	means,as
R3508	T5617	T5618	aux	to,verify
R3509	T5618	T5616	advcl	verify,means
R3510	T5619	T5620	det	the,exons
R3511	T5620	T5618	dobj	exons,verify
R3512	T5621	T5620	amod	predicted,exons
R3513	T5622	T5593	punct	.,used
R3514	T5624	T5625	det	The,structure
R3515	T5625	T5627	nsubjpass	structure,depicted
R3516	T5626	T5625	amod	general,structure
R3517	T5628	T5625	prep	of,structure
R3518	T5629	T5630	det	the,genes
R3519	T5630	T5628	pobj	genes,of
R3520	T5631	T5630	compound	TACC,genes
R3521	T5632	T5630	cc	and,genes
R3522	T5633	T5630	conj	proteins,genes
R3523	T5634	T5627	auxpass	is,depicted
R3524	T5635	T5627	prep	in,depicted
R3525	T5636	T5635	pobj	Fig.,in
R3526	T5637	T5636	nummod	4,Fig.
R3527	T5638	T5627	punct	.,depicted
R3528	T5640	T5641	det	The,feature
R3529	T5641	T5644	nsubjpass	feature,located
R3530	T5642	T5641	amod	main,feature
R3531	T5643	T5641	amod	conserved,feature
R3532	T5645	T5641	prep	of,feature
R3533	T5646	T5647	det	the,family
R3534	T5647	T5645	pobj	family,of
R3535	T5648	T5647	compound	TACC,family
R3536	T5649	T5641	punct	", ",feature
R3537	T5650	T5651	det	the,domain
R3538	T5651	T5641	appos	domain,feature
R3539	T5652	T5651	compound	TACC,domain
R3540	T5653	T5644	punct	", ",located
R3541	T5654	T5644	auxpass	is,located
R3542	T5655	T5644	prep	at,located
R3543	T5656	T5657	det	the,terminus
R3544	T5657	T5655	pobj	terminus,at
R3545	T5658	T5657	compound	carboxy,terminus
R3546	T5659	T5657	prep	of,terminus
R3547	T5660	T5661	det	the,protein
R3548	T5661	T5659	pobj	protein,of
R3549	T5662	T5644	punct	.,located
R3550	T5664	T5665	prep	In,comprises
R3551	T5666	T5667	det	the,case
R3552	T5667	T5664	pobj	case,In
R3553	T5668	T5667	prep	of,case
R3554	T5669	T5670	det	the,protein
R3555	T5670	T5668	pobj	protein,of
R3556	T5671	T5672	compound	C.,elegans
R3557	T5672	T5670	compound	elegans,protein
R3558	T5673	T5670	compound	TAC,protein
R3559	T5674	T5665	punct	", ",comprises
R3560	T5675	T5676	det	this,structure
R3561	T5676	T5665	nsubj	structure,comprises
R3562	T5677	T5678	det	the,majority
R3563	T5678	T5665	dobj	majority,comprises
R3564	T5679	T5678	prep	of,majority
R3565	T5680	T5681	det	the,protein
R3566	T5681	T5679	pobj	protein,of
R3567	T5682	T5665	cc	and,comprises
R3568	T5683	T5684	auxpass	is,encoded
R3569	T5684	T5665	conj	encoded,comprises
R3570	T5685	T5684	agent	by,encoded
R3571	T5686	T5685	pobj	two,by
R3572	T5687	T5686	prep	of,two
R3573	T5688	T5689	det	the,exons
R3574	T5689	T5687	pobj	exons,of
R3575	T5690	T5689	nummod	three,exons
R3576	T5691	T5689	prep	of,exons
R3577	T5692	T5693	det	the,gene
R3578	T5693	T5691	pobj	gene,of
R3579	T5694	T5665	punct	.,comprises
R3580	T5696	T5697	prep	In,encoded
R3581	T5698	T5699	det	the,organisms
R3582	T5699	T5696	pobj	organisms,In
R3583	T5700	T5699	amod	higher,organisms
R3584	T5701	T5699	punct	", ",organisms
R3585	T5702	T5703	compound	D.,melanogaster
R3586	T5703	T5699	appos	melanogaster,organisms
R3587	T5704	T5703	punct	", ",melanogaster
R3588	T5705	T5703	cc	and,melanogaster
R3589	T5706	T5707	det	the,intestinalis
R3590	T5707	T5703	conj	intestinalis,melanogaster
R3591	T5708	T5709	compound	deuterostomes,C.
R3592	T5709	T5707	compound	C.,intestinalis
R3593	T5710	T5707	prep	to,intestinalis
R3594	T5711	T5710	pobj	human,to
R3595	T5712	T5697	punct	", ",encoded
R3596	T5713	T5714	det	this,feature
R3597	T5714	T5697	nsubjpass	feature,encoded
R3598	T5715	T5697	auxpass	is,encoded
R3599	T5716	T5697	advmod	also,encoded
R3600	T5717	T5697	agent	by,encoded
R3601	T5718	T5719	det	the,exons
R3602	T5719	T5717	pobj	exons,by
R3603	T5720	T5719	amod	final,exons
R3604	T5721	T5719	prep	of,exons
R3605	T5722	T5723	det	the,gene
R3606	T5723	T5721	pobj	gene,of
R3607	T5724	T5725	punct	(,five
R3608	T5725	T5697	parataxis	five,encoded
R3609	T5726	T5725	prep	in,five
R3610	T5727	T5728	compound	D.,melanogaster
R3611	T5728	T5726	pobj	melanogaster,in
R3612	T5729	T5725	punct	", ",five
R3613	T5730	T5725	appos	seven,five
R3614	T5731	T5730	prep	in,seven
R3615	T5732	T5733	det	the,genes
R3616	T5733	T5731	pobj	genes,in
R3617	T5734	T5733	compound	deuterostome,genes
R3618	T5735	T5725	punct	),five
R3619	T5736	T5697	punct	.,encoded
R3620	T5738	T5739	prep	Outside,show
R3621	T5740	T5738	prep	of,Outside
R3622	T5741	T5742	det	the,domain
R3623	T5742	T5740	pobj	domain,of
R3624	T5743	T5742	compound	TACC,domain
R3625	T5744	T5739	punct	", ",show
R3626	T5745	T5739	advmod	however,show
R3627	T5746	T5739	punct	", ",show
R3628	T5747	T5748	compound	TACC,members
R3629	T5748	T5739	nsubj	members,show
R3630	T5749	T5748	compound	family,members
R3631	T5750	T5751	advmod	relatively,little
R3632	T5751	T5752	amod	little,homology
R3633	T5752	T5739	dobj	homology,show
R3634	T5753	T5739	punct	.,show
R3635	T5755	T5756	nsubj	It,is
R3636	T5757	T5756	acomp	interesting,is
R3637	T5758	T5759	mark	that,contains
R3638	T5759	T5756	ccomp	contains,is
R3639	T5760	T5761	det	each,gene
R3640	T5761	T5759	nsubj	gene,contains
R3641	T5762	T5761	compound	TACC,gene
R3642	T5763	T5764	nummod	one,exon
R3643	T5764	T5759	dobj	exon,contains
R3644	T5765	T5764	amod	large,exon
R3645	T5766	T5764	punct	", ",exon
R3646	T5767	T5768	dep	which,shows
R3647	T5768	T5764	relcl	shows,exon
R3648	T5769	T5770	amod	considerable,variability
R3649	T5770	T5768	dobj	variability,shows
R3650	T5771	T5768	prep	between,shows
R3651	T5772	T5773	compound	TACC,orthologues
R3652	T5773	T5771	pobj	orthologues,between
R3653	T5774	T5768	punct	", ",shows
R3654	T5775	T5768	cc	and,shows
R3655	T5776	T5768	conj	constitutes,shows
R3656	T5777	T5778	det	the,difference
R3657	T5778	T5776	dobj	difference,constitutes
R3658	T5779	T5778	amod	main,difference
R3659	T5780	T5778	prep	between,difference
R3660	T5781	T5782	det	the,genes
R3661	T5782	T5780	pobj	genes,between
R3662	T5783	T5782	compound	TACC3,genes
R3663	T5784	T5776	prep	in,constitutes
R3664	T5785	T5786	det	the,vertebrates
R3665	T5786	T5784	pobj	vertebrates,in
R3666	T5787	T5788	punct	(,see
R3667	T5788	T5759	parataxis	see,contains
R3668	T5789	T5788	advmod	below,see
R3669	T5790	T5788	punct	),see
R3670	T5791	T5756	punct	.,is
R3671	T5793	T5794	prep	In,contains
R3672	T5795	T5793	pobj	deuterostomes,In
R3673	T5796	T5794	punct	", ",contains
R3674	T5797	T5798	det	this,exon
R3675	T5798	T5794	nsubj	exon,contains
R3676	T5799	T5800	det	the,repeat
R3677	T5800	T5794	dobj	repeat,contains
R3678	T5801	T5800	compound	SDP,repeat
R3679	T5802	T5800	punct	(,repeat
R3680	T5803	T5800	cc	or,repeat
R3681	T5804	T5805	prep	in,repeat
R3682	T5805	T5800	conj	repeat,repeat
R3683	T5806	T5807	det	the,case
R3684	T5807	T5804	pobj	case,in
R3685	T5808	T5807	prep	of,case
R3686	T5809	T5810	det	the,TACC3
R3687	T5810	T5808	pobj	TACC3,of
R3688	T5811	T5810	amod	murine,TACC3
R3689	T5812	T5810	case	's,TACC3
R3690	T5813	T5805	punct	", ",repeat
R3691	T5814	T5805	det	a,repeat
R3692	T5815	T5816	npadvmod	rodent,specific
R3693	T5816	T5805	amod	specific,repeat
R3694	T5817	T5816	punct	-,specific
R3695	T5818	T5819	nummod	24,acid
R3696	T5819	T5805	compound	acid,repeat
R3697	T5820	T5819	compound	amino,acid
R3698	T5821	T5800	punct	),repeat
R3699	T5822	T5800	punct	", ",repeat
R3700	T5823	T5824	dep	which,is
R3701	T5824	T5800	relcl	is,repeat
R3702	T5825	T5824	acomp	responsible,is
R3703	T5826	T5825	prep	for,responsible
R3704	T5827	T5828	det	the,binding
R3705	T5828	T5826	pobj	binding,for
R3706	T5829	T5828	prep	of,binding
R3707	T5830	T5831	det	the,component
R3708	T5831	T5829	pobj	component,of
R3709	T5832	T5833	nmod	SWI,SNF
R3710	T5833	T5831	nmod	SNF,component
R3711	T5834	T5833	punct	/,SNF
R3712	T5835	T5836	compound	chromatin,remodeling
R3713	T5836	T5833	appos	remodeling,SNF
R3714	T5837	T5833	amod	complex,SNF
R3715	T5838	T5831	appos	GAS41,component
R3716	T5839	T5840	punct	[,16
R3717	T5840	T5824	parataxis	16,is
R3718	T5841	T5840	nummod	15,16
R3719	T5842	T5840	punct	",",16
R3720	T5843	T5840	punct	],16
R3721	T5844	T5794	punct	.,contains
R3722	T5846	T5847	prep	Of,show
R3723	T5848	T5849	det	the,proteins
R3724	T5849	T5846	pobj	proteins,Of
R3725	T5850	T5849	compound	vertebrate,proteins
R3726	T5851	T5849	compound	TACC,proteins
R3727	T5852	T5847	punct	", ",show
R3728	T5853	T5854	det	the,orthologues
R3729	T5854	T5847	nsubj	orthologues,show
R3730	T5855	T5854	compound	TACC3,orthologues
R3731	T5856	T5857	det	the,variability
R3732	T5857	T5847	dobj	variability,show
R3733	T5858	T5857	amod	greatest,variability
R3734	T5859	T5857	prep	in,variability
R3735	T5860	T5859	pobj	size,in
R3736	T5861	T5860	cc	and,size
R3737	T5862	T5860	conj	sequence,size
R3738	T5863	T5847	punct	", ",show
R3739	T5864	T5847	advcl	ranging,show
R3740	T5865	T5864	prep	in,ranging
R3741	T5866	T5865	pobj	size,in
R3742	T5867	T5864	prep	from,ranging
R3743	T5868	T5869	nummod	599,acids
R3744	T5869	T5867	pobj	acids,from
R3745	T5870	T5869	compound	amino,acids
R3746	T5871	T5869	prep	for,acids
R3747	T5872	T5873	det	the,protein
R3748	T5873	T5871	pobj	protein,for
R3749	T5874	T5873	compound	rat,protein
R3750	T5875	T5873	compound	TACC3,protein
R3751	T5876	T5867	punct	", ",from
R3752	T5877	T5867	prep	to,from
R3753	T5878	T5879	nummod	942,acids
R3754	T5879	T5877	pobj	acids,to
R3755	T5880	T5879	compound	amino,acids
R3756	T5881	T5879	prep	in,acids
R3757	T5882	T5883	det	the,protein
R3758	T5883	T5881	pobj	protein,in
R3759	T5884	T5883	compound	Danio,protein
R3760	T5885	T5883	compound	rerio,protein
R3761	T5886	T5847	punct	.,show
R3762	T5888	T5889	det	The,reasons
R3763	T5889	T5890	nsubj	reasons,are
R3764	T5891	T5889	prep	for,reasons
R3765	T5892	T5893	det	these,differences
R3766	T5893	T5891	pobj	differences,for
R3767	T5894	T5890	acomp	apparent,are
R3768	T5895	T5890	prep	from,are
R3769	T5896	T5897	det	the,structure
R3770	T5897	T5895	pobj	structure,from
R3771	T5898	T5897	amod	genomic,structure
R3772	T5899	T5897	prep	of,structure
R3773	T5900	T5901	det	the,orthologues
R3774	T5901	T5899	pobj	orthologues,of
R3775	T5902	T5901	compound	TACC3,orthologues
R3776	T5903	T5890	punct	.,are
R3777	T5905	T5906	nsubjpass	TACC3,divided
R3778	T5907	T5906	aux	can,divided
R3779	T5908	T5906	auxpass	be,divided
R3780	T5909	T5906	prep	into,divided
R3781	T5910	T5911	nummod	three,sections
R3782	T5911	T5909	pobj	sections,into
R3783	T5912	T5911	punct	: ,sections
R3784	T5913	T5914	det	a,region
R3785	T5914	T5911	appos	region,sections
R3786	T5915	T5914	amod	conserved,region
R3787	T5916	T5917	npadvmod	N,terminal
R3788	T5917	T5914	amod	terminal,region
R3789	T5918	T5917	punct	-,terminal
R3790	T5919	T5914	punct	(,region
R3791	T5920	T5914	appos	CNTR,region
R3792	T5921	T5914	punct	),region
R3793	T5922	T5914	prep	of,region
R3794	T5923	T5924	nummod	108,acids
R3795	T5924	T5922	pobj	acids,of
R3796	T5925	T5924	compound	amino,acids
R3797	T5926	T5924	punct	", ",acids
R3798	T5927	T5924	acl	encoded,acids
R3799	T5928	T5927	agent	by,encoded
R3800	T5929	T5930	nmod	exons,2
R3801	T5930	T5928	pobj	2,by
R3802	T5931	T5930	cc	and,2
R3803	T5932	T5930	conj	3,2
R3804	T5933	T5927	prep	in,encoded
R3805	T5934	T5935	det	each,gene
R3806	T5935	T5933	pobj	gene,in
R3807	T5936	T5935	compound	vertebrate,gene
R3808	T5937	T5935	compound	TACC3,gene
R3809	T5938	T5914	punct	", ",region
R3810	T5939	T5940	det	the,domain
R3811	T5940	T5914	conj	domain,region
R3812	T5941	T5940	amod	conserved,domain
R3813	T5942	T5940	compound	TACC,domain
R3814	T5943	T5940	acl	distributed,domain
R3815	T5944	T5943	prep	over,distributed
R3816	T5945	T5946	det	the,exons
R3817	T5946	T5944	pobj	exons,over
R3818	T5947	T5946	amod	final,exons
R3819	T5948	T5946	nummod	seven,exons
R3820	T5949	T5940	punct	", ",domain
R3821	T5950	T5940	cc	and,domain
R3822	T5951	T5952	det	a,region
R3823	T5952	T5940	conj	region,domain
R3824	T5953	T5954	advmod	highly,variable
R3825	T5954	T5952	amod	variable,region
R3826	T5955	T5952	amod	central,region
R3827	T5956	T5906	punct	.,divided
R3828	T5958	T5959	det	The,lack
R3829	T5959	T5960	nsubjpass	lack,noted
R3830	T5961	T5959	prep	of,lack
R3831	T5962	T5961	pobj	conservation,of
R3832	T5963	T5962	prep	in,conservation
R3833	T5964	T5965	preconj	both,size
R3834	T5965	T5963	pobj	size,in
R3835	T5966	T5965	cc	and,size
R3836	T5967	T5965	conj	sequence,size
R3837	T5968	T5965	prep	of,size
R3838	T5969	T5970	det	the,portion
R3839	T5970	T5968	pobj	portion,of
R3840	T5971	T5970	amod	central,portion
R3841	T5972	T5970	prep	of,portion
R3842	T5973	T5974	det	the,proteins
R3843	T5974	T5972	pobj	proteins,of
R3844	T5975	T5974	compound	TACC3,proteins
R3845	T5976	T5974	prep	of,proteins
R3846	T5977	T5978	amod	human,mouse
R3847	T5978	T5976	pobj	mouse,of
R3848	T5979	T5978	cc	and,mouse
R3849	T5980	T5960	aux	has,noted
R3850	T5981	T5960	auxpass	been,noted
R3851	T5982	T5960	advmod	previously,noted
R3852	T5983	T5960	punct	", ",noted
R3853	T5984	T5960	cc	and,noted
R3854	T5985	T5960	conj	accounts,noted
R3855	T5986	T5985	prep	for,accounts
R3856	T5987	T5988	det	the,difference
R3857	T5988	T5986	pobj	difference,for
R3858	T5989	T5988	amod	major,difference
R3859	T5990	T5988	prep	between,difference
R3860	T5991	T5992	det	these,orthologues
R3861	T5992	T5990	pobj	orthologues,between
R3862	T5993	T5992	nummod	two,orthologues
R3863	T5994	T5995	punct	[,2
R3864	T5995	T5985	parataxis	2,accounts
R3865	T5996	T5995	punct	],2
R3866	T5997	T5960	punct	.,noted
R3867	T5999	T6000	det	The,majority
R3868	T6000	T6001	nsubjpass	majority,encoded
R3869	T6002	T6000	prep	of,majority
R3870	T6003	T6004	det	this,portion
R3871	T6004	T6002	pobj	portion,of
R3872	T6005	T6004	amod	central,portion
R3873	T6006	T6004	punct	", ",portion
R3874	T6007	T6008	dep	which,contains
R3875	T6008	T6004	relcl	contains,portion
R3876	T6009	T6010	det	the,motifs
R3877	T6010	T6008	dobj	motifs,contains
R3878	T6011	T6010	compound	SDP,motifs
R3879	T6012	T6010	compound	repeat,motifs
R3880	T6013	T6001	punct	", ",encoded
R3881	T6014	T6001	auxpass	is,encoded
R3882	T6015	T6001	agent	by,encoded
R3883	T6016	T6017	nummod	one,exon
R3884	T6017	T6015	pobj	exon,by
R3885	T6018	T6001	prep	in,encoded
R3886	T6019	T6018	pobj	human,in
R3887	T6020	T6019	cc	and,human
R3888	T6021	T6022	det	the,pufferfish
R3889	T6022	T6019	conj	pufferfish,human
R3890	T6023	T6024	punct	(,emb\|CAAB01001184
R3891	T6024	T6001	parataxis	emb\|CAAB01001184,encoded
R3892	T6025	T6024	punct	),emb\|CAAB01001184
R3893	T6026	T6001	punct	.,encoded
R3894	T6028	T6029	prep	In,composed
R3895	T6030	T6028	pobj	rodents,In
R3896	T6031	T6029	punct	", ",composed
R3897	T6032	T6029	advmod	however,composed
R3898	T6033	T6029	punct	", ",composed
R3899	T6034	T6035	det	this,region
R3900	T6035	T6029	nsubjpass	region,composed
R3901	T6036	T6029	auxpass	is,composed
R3902	T6037	T6038	advmod	almost,entirely
R3903	T6038	T6029	advmod	entirely,composed
R3904	T6039	T6029	prep	of,composed
R3905	T6040	T6041	nummod	seven,repeats
R3906	T6041	T6039	pobj	repeats,of
R3907	T6042	T6043	nummod	24,acid
R3908	T6043	T6041	compound	acid,repeats
R3909	T6044	T6043	compound	amino,acid
R3910	T6045	T6041	punct	", ",repeats
R3911	T6046	T6047	dep	which,located
R3912	T6047	T6041	relcl	located,repeats
R3913	T6048	T6047	auxpass	are,located
R3914	T6049	T6047	prep	in,located
R3915	T6050	T6051	det	a,exon
R3916	T6051	T6049	pobj	exon,in
R3917	T6052	T6051	amod	single,exon
R3918	T6053	T6051	prep	of,exon
R3919	T6054	T6055	det	the,genes
R3920	T6055	T6053	pobj	genes,of
R3921	T6056	T6055	nmod	mouse,genes
R3922	T6057	T6056	cc	and,mouse
R3923	T6058	T6056	conj	rat,mouse
R3924	T6059	T6055	compound	TACC3,genes
R3925	T6060	T6029	punct	.,composed
R3926	T6062	T6063	nsubjpass	It,reported
R3927	T6064	T6063	aux	has,reported
R3928	T6065	T6063	auxpass	been,reported
R3929	T6066	T6063	advmod	previously,reported
R3930	T6067	T6068	mark	that,are
R3931	T6068	T6063	ccomp	are,reported
R3932	T6069	T6068	expl	there,are
R3933	T6070	T6071	nummod	four,variants
R3934	T6071	T6068	attr	variants,are
R3935	T6072	T6073	compound	mouse,TACC3
R3936	T6073	T6071	compound	TACC3,variants
R3937	T6074	T6071	compound	splice,variants
R3938	T6075	T6076	dep	that,differ
R3939	T6076	T6071	relcl	differ,variants
R3940	T6077	T6076	prep	in,differ
R3941	T6078	T6079	det	the,number
R3942	T6079	T6077	pobj	number,in
R3943	T6080	T6079	prep	of,number
R3944	T6081	T6082	det	these,repeats
R3945	T6082	T6080	pobj	repeats,of
R3946	T6083	T6084	punct	[,17
R3947	T6084	T6063	parataxis	17,reported
R3948	T6085	T6084	nummod	2,17
R3949	T6086	T6084	punct	",",17
R3950	T6087	T6084	nummod	7,17
R3951	T6088	T6084	punct	",",17
R3952	T6089	T6084	punct	],17
R3953	T6090	T6063	punct	.,reported
R3954	T6092	T6093	mark	As,are
R3955	T6093	T6096	advcl	are,appears
R3956	T6094	T6095	det	these,repeats
R3957	T6095	T6093	nsubj	repeats,are
R3958	T6097	T6093	acomp	present,are
R3959	T6098	T6093	prep	in,are
R3960	T6099	T6100	det	a,exon
R3961	T6100	T6098	pobj	exon,in
R3962	T6101	T6100	amod	single,exon
R3963	T6102	T6096	punct	", ",appears
R3964	T6103	T6096	nsubj	it,appears
R3965	T6104	T6096	oprd	likely,appears
R3966	T6105	T6106	mark	that,be
R3967	T6106	T6096	ccomp	be,appears
R3968	T6107	T6108	det	these,sequences
R3969	T6108	T6106	nsubj	sequences,be
R3970	T6109	T6108	amod	different,sequences
R3971	T6110	T6106	aux	may,be
R3972	T6111	T6112	det	the,result
R3973	T6112	T6106	attr	result,be
R3974	T6113	T6112	prep	of,result
R3975	T6114	T6115	det	the,polymerases
R3976	T6115	T6113	pobj	polymerases,of
R3977	T6116	T6115	compound	DNA,polymerases
R3978	T6117	T6115	acl	used,polymerases
R3979	T6118	T6117	prep	in,used
R3980	T6119	T6120	det	the,synthesis
R3981	T6120	T6118	pobj	synthesis,in
R3982	T6121	T6120	compound	cDNA,synthesis
R3983	T6122	T6115	cc	and,polymerases
R3984	T6123	T6122	punct	/,and
R3985	T6124	T6122	cc	or,and
R3986	T6125	T6126	compound	PCR,reaction
R3987	T6126	T6127	nsubj	reaction,stuttering
R3988	T6127	T6115	conj	stuttering,polymerases
R3989	T6128	T6127	prep	through,stuttering
R3990	T6129	T6130	det	the,motif
R3991	T6130	T6128	pobj	motif,through
R3992	T6131	T6130	compound	repeat,motif
R3993	T6132	T6096	punct	.,appears
R3994	T6134	T6135	det	The,sequence
R3995	T6135	T6137	nsubj	sequence,is
R3996	T6136	T6135	amod	correct,sequence
R3997	T6138	T6135	punct	", ",sequence
R3998	T6139	T6135	acl	reported,sequence
R3999	T6140	T6139	agent	by,reported
R4000	T6141	T6140	pobj	Sadek,by
R4001	T6142	T6143	advmod	et,al
R4002	T6143	T6141	advmod	al,Sadek
R4003	T6144	T6145	punct	[,7
R4004	T6145	T6139	parataxis	7,reported
R4005	T6146	T6145	punct	],7
R4006	T6147	T6137	punct	", ",is
R4007	T6148	T6149	det	the,one
R4008	T6149	T6137	attr	one,is
R4009	T6150	T6149	acl	used,one
R4010	T6151	T6150	prep	throughout,used
R4011	T6152	T6153	det	the,entirety
R4012	T6153	T6151	pobj	entirety,throughout
R4013	T6154	T6153	prep	of,entirety
R4014	T6155	T6156	det	this,manuscript
R4015	T6156	T6154	pobj	manuscript,of
R4016	T6157	T6137	punct	.,is
R4017	T6159	T6160	det	These,repeats
R4018	T6160	T6161	nsubj	repeats,are
R4019	T6162	T6161	neg	not,are
R4020	T6163	T6161	acomp	evident,are
R4021	T6164	T6161	prep	in,are
R4022	T6165	T6166	det	the,protein
R4023	T6166	T6164	pobj	protein,in
R4024	T6167	T6166	compound	rabbit,protein
R4025	T6168	T6166	punct	", ",protein
R4026	T6169	T6166	cc	or,protein
R4027	T6170	T6171	det	any,protein
R4028	T6171	T6166	conj	protein,protein
R4029	T6172	T6171	amod	other,protein
R4030	T6173	T6171	compound	TACC,protein
R4031	T6174	T6161	punct	", ",are
R4032	T6175	T6161	cc	and,are
R4033	T6176	T6177	aux	may,indicate
R4034	T6177	T6161	conj	indicate,are
R4035	T6178	T6179	mark	that,evolved
R4036	T6179	T6177	ccomp	evolved,indicate
R4037	T6180	T6181	det	the,TACC3
R4038	T6181	T6179	nsubj	TACC3,evolved
R4039	T6182	T6181	compound	rodent,TACC3
R4040	T6183	T6179	aux	has,evolved
R4041	T6184	T6185	amod	distinct,functions
R4042	T6185	T6179	dobj	functions,evolved
R4043	T6186	T6177	punct	", ",indicate
R4044	T6187	T6188	mark	as,noted
R4045	T6188	T6177	advcl	noted,indicate
R4046	T6189	T6188	aux	has,noted
R4047	T6190	T6188	advmod	already,noted
R4048	T6191	T6188	auxpass	been,noted
R4049	T6192	T6188	prep	for,noted
R4050	T6193	T6194	det	the,TACC3
R4051	T6194	T6192	pobj	TACC3,for
R4052	T6195	T6194	amod	amphibian,TACC3
R4053	T6196	T6194	compound	Xenopus,TACC3
R4054	T6197	T6194	punct	", ",TACC3
R4055	T6198	T6194	appos	maskin,TACC3
R4056	T6199	T6200	punct	[,8
R4057	T6200	T6188	parataxis	8,noted
R4058	T6201	T6200	punct	],8
R4059	T6202	T6161	punct	.,are
R4064	T6381	T6382	amod	Alternative,splicing
R4065	T6383	T6382	prep	in,splicing
R4066	T6384	T6385	compound	vertebrate,genes
R4067	T6385	T6383	pobj	genes,in
R4068	T6386	T6385	compound	TACC,genes
R4069	T6388	T6389	mark	Whereas,drive
R4070	T6389	T6393	advcl	drive,give
R4071	T6390	T6391	compound	exon,shuffling
R4072	T6391	T6389	nsubj	shuffling,drive
R4073	T6392	T6389	aux	can,drive
R4074	T6394	T6395	det	the,diversification
R4075	T6395	T6389	dobj	diversification,drive
R4076	T6396	T6395	amod	functional,diversification
R4077	T6397	T6395	prep	of,diversification
R4078	T6398	T6399	compound	gene,families
R4079	T6399	T6397	pobj	families,of
R4080	T6400	T6389	prep	over,drive
R4081	T6401	T6402	amod	evolutionary,time
R4082	T6402	T6400	pobj	time,over
R4083	T6403	T6393	punct	", ",give
R4084	T6404	T6405	det	the,splicing
R4085	T6405	T6393	nsubj	splicing,give
R4086	T6406	T6405	amod	temporal,splicing
R4087	T6407	T6406	cc	and,temporal
R4088	T6408	T6407	punct	/,and
R4089	T6409	T6407	cc	or,and
R4090	T6410	T6411	npadvmod	tissue,specific
R4091	T6411	T6406	conj	specific,temporal
R4092	T6412	T6405	amod	alternative,splicing
R4093	T6413	T6405	prep	of,splicing
R4094	T6414	T6415	det	a,gene
R4095	T6415	T6413	pobj	gene,of
R4096	T6416	T6393	aux	can,give
R4097	T6417	T6393	dobj	rise,give
R4098	T6418	T6393	prep	to,give
R4099	T6419	T6420	amod	functional,diversification
R4100	T6420	T6418	pobj	diversification,to
R4101	T6421	T6420	prep	of,diversification
R4102	T6422	T6423	det	a,gene
R4103	T6423	T6421	pobj	gene,of
R4104	T6424	T6423	amod	single,gene
R4105	T6425	T6393	prep	during,give
R4106	T6426	T6427	det	the,development
R4107	T6427	T6425	pobj	development,during
R4108	T6428	T6427	prep	of,development
R4109	T6429	T6430	det	an,organism
R4110	T6430	T6428	pobj	organism,of
R4111	T6431	T6393	punct	.,give
R4112	T6433	T6434	mark	Although,documented
R4113	T6434	T6443	advcl	documented,observed
R4114	T6435	T6436	det	no,splicing
R4115	T6436	T6434	nsubjpass	splicing,documented
R4116	T6437	T6436	amod	alternative,splicing
R4117	T6438	T6436	prep	of,splicing
R4118	T6439	T6438	pobj	TACC3,of
R4119	T6440	T6434	aux	has,documented
R4120	T6441	T6434	auxpass	been,documented
R4121	T6442	T6434	advmod	clearly,documented
R4122	T6444	T6443	punct	", ",observed
R4123	T6445	T6446	preconj	both,temporal
R4124	T6446	T6447	amod	temporal,splicing
R4125	T6447	T6443	nsubjpass	splicing,observed
R4126	T6448	T6446	cc	and,temporal
R4127	T6449	T6450	npadvmod	tissue,specific
R4128	T6450	T6446	conj	specific,temporal
R4129	T6451	T6443	auxpass	is,observed
R4130	T6452	T6443	prep	in,observed
R4131	T6453	T6454	det	the,genes
R4132	T6454	T6452	pobj	genes,in
R4133	T6455	T6454	nmod	TACC1,genes
R4134	T6456	T6455	cc	and,TACC1
R4135	T6457	T6455	conj	TACC2,TACC1
R4136	T6458	T6443	punct	.,observed
R4137	T6460	T6461	prep	In,accounts
R4138	T6462	T6463	det	the,case
R4139	T6463	T6460	pobj	case,In
R4140	T6464	T6463	prep	of,case
R4141	T6465	T6464	pobj	TACC2,of
R4142	T6466	T6461	punct	", ",accounts
R4143	T6467	T6468	det	an,exon
R4144	T6468	T6461	nsubj	exon,accounts
R4145	T6469	T6468	amod	additional,exon
R4146	T6470	T6468	amod	large,exon
R4147	T6471	T6472	punct	(,kb
R4148	T6472	T6470	parataxis	kb,large
R4149	T6473	T6472	nummod	5,kb
R4150	T6474	T6472	punct	),kb
R4151	T6475	T6461	prep	for,accounts
R4152	T6476	T6477	det	the,difference
R4153	T6477	T6475	pobj	difference,for
R4154	T6478	T6477	amod	main,difference
R4155	T6479	T6477	prep	between,difference
R4156	T6480	T6481	det	the,variants
R4157	T6481	T6479	pobj	variants,between
R4158	T6482	T6481	amod	major,variants
R4159	T6483	T6481	compound	splice,variants
R4160	T6484	T6481	prep	of,variants
R4161	T6485	T6486	det	the,genes
R4162	T6486	T6484	pobj	genes,of
R4163	T6487	T6486	compound	vertebrate,genes
R4164	T6488	T6486	compound	TACC2,genes
R4165	T6489	T6490	punct	[,3
R4166	T6490	T6461	parataxis	3,accounts
R4167	T6491	T6490	punct	],3
R4168	T6492	T6461	punct	.,accounts
R4169	T6494	T6495	det	The,splicing
R4170	T6495	T6497	nsubj	splicing,suggests
R4171	T6496	T6495	amod	alternative,splicing
R4172	T6498	T6495	prep	of,splicing
R4173	T6499	T6500	det	this,exon
R4174	T6500	T6498	pobj	exon,of
R4175	T6501	T6502	det	a,difference
R4176	T6502	T6497	dobj	difference,suggests
R4177	T6503	T6502	amod	major,difference
R4178	T6504	T6502	amod	functional,difference
R4179	T6505	T6502	prep	between,difference
R4180	T6506	T6507	det	the,isoforms
R4181	T6507	T6505	pobj	isoforms,between
R4182	T6508	T6507	nummod	two,isoforms
R4183	T6509	T6507	compound	TACC2,isoforms
R4184	T6510	T6507	punct	", ",isoforms
R4185	T6511	T6507	appos	TACC2s,isoforms
R4186	T6512	T6511	cc	and,TACC2s
R4187	T6513	T6511	conj	TACC2l,TACC2s
R4188	T6514	T6515	punct	[,3
R4189	T6515	T6502	parataxis	3,difference
R4190	T6516	T6515	punct	],3
R4191	T6517	T6502	punct	", ",difference
R4192	T6518	T6519	advmod	as,as
R4193	T6519	T6502	cc	as,difference
R4194	T6520	T6519	advmod	well,as
R4195	T6521	T6522	det	a,difference
R4196	T6522	T6502	conj	difference,difference
R4197	T6523	T6522	amod	significant,difference
R4198	T6524	T6522	prep	between,difference
R4199	T6525	T6524	pobj	TACC2,between
R4200	T6526	T6525	cc	and,TACC2
R4201	T6527	T6528	poss	its,relative
R4202	T6528	T6525	conj	relative,TACC2
R4203	T6529	T6528	amod	closest,relative
R4204	T6530	T6531	compound	TACC,family
R4205	T6531	T6528	compound	family,relative
R4206	T6532	T6528	punct	", ",relative
R4207	T6533	T6528	appos	TACC1,relative
R4208	T6534	T6497	punct	.,suggests
R4209	T6536	T6537	advmod	However,is
R4210	T6538	T6537	punct	", ",is
R4211	T6539	T6540	det	the,function
R4212	T6540	T6537	nsubj	function,is
R4213	T6541	T6540	prep	of,function
R4214	T6542	T6543	det	this,region
R4215	T6543	T6541	pobj	region,of
R4216	T6544	T6543	prep	of,region
R4217	T6545	T6546	det	the,isoform
R4218	T6546	T6544	pobj	isoform,of
R4219	T6547	T6546	compound	TACC2l,isoform
R4220	T6548	T6537	advmod	current,is
R4221	T6549	T6537	acomp	unknown,is
R4222	T6550	T6537	punct	.,is
R4223	T6552	T6553	amod	Alternative,splicing
R4224	T6553	T6554	nsubjpass	splicing,noted
R4225	T6555	T6553	punct	", ",splicing
R4226	T6556	T6553	advmod	together,splicing
R4227	T6557	T6556	prep	with,together
R4228	T6558	T6559	amod	differential,usage
R4229	T6559	T6557	pobj	usage,with
R4230	T6560	T6559	compound	promoter,usage
R4231	T6561	T6554	aux	has,noted
R4232	T6562	T6554	advmod	already,noted
R4233	T6563	T6554	auxpass	been,noted
R4234	T6564	T6554	prep	for,noted
R4235	T6565	T6566	det	the,gene
R4236	T6566	T6564	pobj	gene,for
R4237	T6567	T6566	amod	human,gene
R4238	T6568	T6566	compound	TACC1,gene
R4239	T6569	T6570	punct	[,19
R4240	T6570	T6554	parataxis	19,noted
R4241	T6571	T6570	nummod	18,19
R4242	T6572	T6570	punct	",",19
R4243	T6573	T6570	punct	],19
R4244	T6574	T6554	punct	.,noted
R4245	T6576	T6577	prep	In,identified
R4246	T6578	T6576	pobj	addition,In
R4247	T6579	T6577	punct	", ",identified
R4248	T6580	T6581	mark	as,shown
R4249	T6581	T6577	advcl	shown,identified
R4250	T6582	T6581	prep	in,shown
R4251	T6583	T6582	pobj	Fig.,in
R4252	T6584	T6583	nummod	5,Fig.
R4253	T6585	T6577	punct	", ",identified
R4254	T6586	T6577	nsubj	we,identified
R4255	T6587	T6577	aux	have,identified
R4256	T6588	T6589	amod	additional,isoforms
R4257	T6589	T6577	dobj	isoforms,identified
R4258	T6590	T6589	compound	TACC1,isoforms
R4259	T6591	T6592	dep	that,result
R4260	T6592	T6589	relcl	result,isoforms
R4261	T6593	T6592	prep	from,result
R4262	T6594	T6595	amod	alternative,splicing
R4263	T6595	T6593	pobj	splicing,from
R4264	T6596	T6595	prep	of,splicing
R4265	T6597	T6598	nmod	exons,4a
R4266	T6598	T6596	pobj	4a,of
R4267	T6599	T6598	nummod	1b,4a
R4268	T6600	T6598	punct	-,4a
R4269	T6601	T6577	punct	.,identified
R4270	T6603	T6604	det	The,functions
R4271	T6604	T6605	nsubj	functions,are
R4272	T6605	T6610	ccomp	are,include
R4273	T6606	T6604	prep	of,functions
R4274	T6607	T6608	det	these,isoforms
R4275	T6608	T6606	pobj	isoforms,of
R4276	T6609	T6608	amod	different,isoforms
R4277	T6611	T6605	acomp	unknown,are
R4278	T6612	T6610	punct	", ",include
R4279	T6613	T6610	advmod	however,include
R4280	T6614	T6615	det	the,region
R4281	T6615	T6610	nsubj	region,include
R4282	T6616	T6615	acl	deleted,region
R4283	T6617	T6616	prep	from,deleted
R4284	T6618	T6619	det	the,variants
R4285	T6619	T6617	pobj	variants,from
R4286	T6620	T6619	amod	shorter,variants
R4287	T6621	T6610	aux	can,include
R4288	T6622	T6623	det	the,site
R4289	T6623	T6610	dobj	site,include
R4290	T6624	T6623	compound	binding,site
R4291	T6625	T6623	prep	for,site
R4292	T6626	T6625	pobj	LSm7,for
R4293	T6627	T6628	punct	[,20
R4294	T6628	T6623	parataxis	20,site
R4295	T6629	T6628	punct	],20
R4296	T6630	T6631	punct	(,C
R4297	T6631	T6623	parataxis	C,site
R4298	T6632	T6631	compound	variants,C
R4299	T6633	T6631	punct	", ",C
R4300	T6634	T6631	appos	D,C
R4301	T6635	T6631	punct	", ",C
R4302	T6636	T6631	appos	F,C
R4303	T6637	T6638	punct	-,I
R4304	T6638	T6636	prep	I,F
R4305	T6639	T6631	punct	),C
R4306	T6640	T6623	punct	", ",site
R4307	T6641	T6623	cc	and,site
R4308	T6642	T6641	punct	/,and
R4309	T6643	T6641	cc	or,and
R4310	T6644	T6645	det	the,signals
R4311	T6645	T6623	conj	signals,site
R4312	T6646	T6645	amod	nuclear,signals
R4313	T6647	T6645	compound	localization,signals
R4314	T6648	T6645	cc	and,signals
R4315	T6649	T6650	compound	binding,site
R4316	T6650	T6645	conj	site,signals
R4317	T6651	T6650	prep	for,site
R4318	T6652	T6651	pobj	GAS41,for
R4319	T6653	T6654	punct	[,15
R4320	T6654	T6650	parataxis	15,site
R4321	T6655	T6654	punct	],15
R4322	T6656	T6645	cc	and,signals
R4323	T6657	T6645	conj	PCTAIRE2BP,signals
R4324	T6658	T6659	punct	[,20
R4325	T6659	T6657	parataxis	20,PCTAIRE2BP
R4326	T6660	T6659	punct	],20
R4327	T6661	T6662	punct	(,B
R4328	T6662	T6657	parataxis	B,PCTAIRE2BP
R4329	T6663	T6662	compound	isoforms,B
R4330	T6664	T6665	punct	-,D
R4331	T6665	T6662	prep	D,B
R4332	T6666	T6662	punct	", ",B
R4333	T6667	T6662	appos	S,B
R4334	T6668	T6662	punct	),B
R4335	T6669	T6610	punct	.,include
R4336	T6671	T6672	nsubjpass	One,localized
R4337	T6673	T6671	prep	of,One
R4338	T6674	T6675	det	these,isoforms
R4339	T6675	T6673	pobj	isoforms,of
R4340	T6676	T6671	punct	", ",One
R4341	T6677	T6671	appos	TACC1S,One
R4342	T6678	T6672	auxpass	is,localized
R4343	T6679	T6680	advmod	exclusively,to
R4344	T6680	T6672	prep	to,localized
R4345	T6681	T6682	det	the,cytoplasm
R4346	T6682	T6680	pobj	cytoplasm,to
R4347	T6683	T6684	punct	[,19
R4348	T6684	T6672	parataxis	19,localized
R4349	T6685	T6684	punct	],19
R4350	T6686	T6672	punct	", ",localized
R4351	T6687	T6672	advcl	suggesting,localized
R4352	T6688	T6689	mark	that,be
R4353	T6689	T6687	ccomp	be,suggesting
R4354	T6690	T6691	det	the,isoforms
R4355	T6691	T6689	nsubj	isoforms,be
R4356	T6692	T6691	amod	shorter,isoforms
R4357	T6693	T6689	aux	would,be
R4358	T6694	T6689	neg	not,be
R4359	T6695	T6689	acomp	able,be
R4360	T6696	T6697	aux	to,interact
R4361	T6697	T6695	xcomp	interact,able
R4362	T6698	T6697	prep	with,interact
R4363	T6699	T6698	pobj	elements,with
R4364	T6700	T6699	prep	of,elements
R4365	T6701	T6702	det	the,remodeling
R4366	T6702	T6700	pobj	remodeling,of
R4367	T6703	T6702	compound	chomatin,remodeling
R4368	T6704	T6699	cc	and,elements
R4369	T6705	T6704	punct	/,and
R4370	T6706	T6704	cc	or,and
R4371	T6707	T6708	compound	RNA,machinery
R4372	T6708	T6699	conj	machinery,elements
R4373	T6709	T6708	compound	processing,machinery
R4374	T6710	T6697	prep	in,interact
R4375	T6711	T6712	det	the,nucleus
R4376	T6712	T6710	pobj	nucleus,in
R4377	T6713	T6672	punct	.,localized
R4378	T6715	T6716	advmod	Thus,result
R4379	T6717	T6716	punct	", ",result
R4380	T6718	T6716	nsubj	changes,result
R4381	T6719	T6718	prep	in,changes
R4382	T6720	T6721	det	the,complement
R4383	T6721	T6719	pobj	complement,in
R4384	T6722	T6721	prep	of,complement
R4385	T6723	T6724	compound	TACC1,isoforms
R4386	T6724	T6722	pobj	isoforms,of
R4387	T6725	T6718	prep	in,changes
R4388	T6726	T6727	det	the,cell
R4389	T6727	T6725	pobj	cell,in
R4390	T6728	T6716	aux	may,result
R4391	T6729	T6716	prep	in,result
R4392	T6730	T6729	pobj	alterations,in
R4393	T6731	T6730	prep	in,alterations
R4394	T6732	T6733	amod	cellular,metabolism
R4395	T6733	T6731	pobj	metabolism,in
R4396	T6734	T6733	compound	RNA,metabolism
R4397	T6735	T6730	prep	at,alterations
R4398	T6736	T6737	amod	multiple,levels
R4399	T6737	T6735	pobj	levels,at
R4400	T6738	T6716	punct	", ",result
R4401	T6739	T6716	cc	and,result
R4402	T6740	T6741	aux	may,account
R4403	T6741	T6716	conj	account,result
R4404	T6742	T6741	prep	for,account
R4405	T6743	T6744	det	the,observation
R4406	T6744	T6742	pobj	observation,for
R4407	T6745	T6746	mark	that,associated
R4408	T6746	T6744	acl	associated,observation
R4409	T6747	T6748	nmod	TACC1D,isoforms
R4410	T6748	T6746	nsubjpass	isoforms,associated
R4411	T6749	T6747	cc	and,TACC1D
R4412	T6750	T6747	conj	TACC1F,TACC1D
R4413	T6751	T6746	auxpass	are,associated
R4414	T6752	T6746	prep	with,associated
R4415	T6753	T6754	amod	tumorigenic,changes
R4416	T6754	T6752	pobj	changes,with
R4417	T6755	T6746	prep	in,associated
R4418	T6756	T6757	amod	gastric,mucosa
R4419	T6757	T6755	pobj	mucosa,in
R4420	T6758	T6759	punct	[,18
R4421	T6759	T6744	parataxis	18,observation
R4422	T6760	T6759	punct	],18
R4423	T6761	T6716	punct	.,result
R4426	T7167	T7168	advmod	In,silico
R4427	T7168	T7169	amod	silico,modeling
R4428	T7170	T7169	prep	of,modeling
R4429	T7171	T7172	det	the,evolution
R4430	T7172	T7170	pobj	evolution,of
R4431	T7173	T7172	prep	of,evolution
R4432	T7174	T7175	compound	TACC,protein
R4433	T7175	T7176	compound	protein,function
R4434	T7176	T7173	pobj	function,of
R4435	T7178	T7179	det	The,structure
R4436	T7179	T7183	nsubj	structure,suggests
R4437	T7180	T7179	nmod	protein,structure
R4438	T7181	T7180	cc	and,protein
R4439	T7182	T7180	conj	genomic,protein
R4440	T7184	T7179	prep	of,structure
R4441	T7185	T7186	det	the,members
R4442	T7186	T7184	pobj	members,of
R4443	T7187	T7188	amod	present,day
R4444	T7188	T7186	compound	day,members
R4445	T7189	T7190	compound	TACC,family
R4446	T7190	T7186	compound	family,members
R4447	T7191	T7192	mark	that,mediated
R4448	T7192	T7183	ccomp	mediated,suggests
R4449	T7193	T7194	det	the,function
R4450	T7194	T7192	nsubjpass	function,mediated
R4451	T7195	T7194	prep	of,function
R4452	T7196	T7197	det	the,protein
R4453	T7197	T7195	pobj	protein,of
R4454	T7198	T7197	amod	ancestral,protein
R4455	T7199	T7197	compound	TACC,protein
R4456	T7200	T7192	auxpass	was,mediated
R4457	T7201	T7202	advmod	solely,through
R4458	T7202	T7192	prep	through,mediated
R4459	T7203	T7204	det	the,interactions
R4460	T7204	T7202	pobj	interactions,through
R4461	T7205	T7204	prep	of,interactions
R4462	T7206	T7207	det	the,domain
R4463	T7207	T7205	pobj	domain,of
R4464	T7208	T7207	amod	conserved,domain
R4465	T7209	T7207	compound	TACC,domain
R4466	T7210	T7183	punct	.,suggests
R4467	T7212	T7213	advcl	Using,predicted
R4468	T7214	T7215	det	an,model
R4469	T7215	T7212	dobj	model,Using
R4470	T7216	T7217	advmod	in,silico
R4471	T7217	T7215	amod	silico,model
R4472	T7218	T7219	compound	protein,protein
R4473	T7219	T7221	compound	protein,interaction
R4474	T7220	T7219	punct	-,protein
R4475	T7221	T7215	compound	interaction,model
R4476	T7222	T7215	prep	based,model
R4477	T7223	T7222	prep	upon,based
R4478	T7224	T7225	amod	known,components
R4479	T7225	T7223	pobj	components,upon
R4480	T7226	T7227	amod	mitotic,spindle
R4481	T7227	T7225	nmod	spindle,components
R4482	T7228	T7227	cc	and,spindle
R4483	T7229	T7227	conj	centrosomal,spindle
R4484	T7230	T7213	punct	", ",predicted
R4485	T7231	T7213	nsubj	we,predicted
R4486	T7232	T7213	aux	have,predicted
R4487	T7233	T7213	advmod	previously,predicted
R4488	T7234	T7235	det	a,number
R4489	T7235	T7213	dobj	number,predicted
R4490	T7236	T7235	prep	of,number
R4491	T7237	T7238	amod	additional,interactions
R4492	T7238	T7236	pobj	interactions,of
R4493	T7239	T7240	dep	that,conserved
R4494	T7240	T7238	relcl	conserved,interactions
R4495	T7241	T7240	aux	could,conserved
R4496	T7242	T7240	auxpass	be,conserved
R4497	T7243	T7240	prep	between,conserved
R4498	T7244	T7245	det	a,homologue
R4499	T7245	T7243	pobj	homologue,between
R4500	T7246	T7245	amod	functional,homologue
R4501	T7247	T7245	compound	TACC,homologue
R4502	T7248	T7245	prep	in,homologue
R4503	T7249	T7248	pobj	yeast,in
R4504	T7250	T7245	punct	", ",homologue
R4505	T7251	T7245	appos	spc,homologue
R4506	T7252	T7251	punct	-,spc
R4507	T7253	T7251	nummod	72,spc
R4508	T7254	T7245	punct	", ",homologue
R4509	T7255	T7245	cc	and,homologue
R4510	T7256	T7257	nummod	one,proteins
R4511	T7257	T7245	conj	proteins,homologue
R4512	T7258	T7256	cc	or,one
R4513	T7259	T7256	conj	more,one
R4514	T7260	T7257	amod	human,proteins
R4515	T7261	T7257	compound	TACC,proteins
R4516	T7262	T7263	punct	[,21
R4517	T7263	T7213	parataxis	21,predicted
R4518	T7264	T7263	punct	],21
R4519	T7265	T7213	punct	.,predicted
R4520	T7267	T7268	advmod	Thus,known
R4521	T7269	T7268	punct	", ",known
R4522	T7270	T7268	nsubjpass	it,known
R4523	T7271	T7268	auxpass	is,known
R4524	T7272	T7273	mark	that,interact
R4525	T7273	T7268	ccomp	interact,known
R4526	T7274	T7275	predet	all,proteins
R4527	T7275	T7273	nsubj	proteins,interact
R4528	T7276	T7275	det	the,proteins
R4529	T7277	T7275	compound	TACC,proteins
R4530	T7278	T7275	acl	examined,proteins
R4531	T7279	T7278	prep	to,examined
R4532	T7280	T7279	pobj	date,to
R4533	T7281	T7273	punct	", ",interact
R4534	T7282	T7273	prep	via,interact
R4535	T7283	T7284	det	the,domain
R4536	T7284	T7282	pobj	domain,via
R4537	T7285	T7284	compound	TACC,domain
R4538	T7286	T7273	punct	", ",interact
R4539	T7287	T7273	prep	with,interact
R4540	T7288	T7289	det	the,proteins
R4541	T7289	T7287	pobj	proteins,with
R4542	T7290	T7291	npadvmod	microtubule,centrosomal
R4543	T7291	T7289	amod	centrosomal,proteins
R4544	T7292	T7291	punct	/,centrosomal
R4545	T7293	T7289	prep	of,proteins
R4546	T7294	T7295	det	the,family
R4547	T7295	T7293	pobj	family,of
R4548	T7296	T7295	nmod	stu2,family
R4549	T7297	T7296	punct	/,stu2
R4550	T7298	T7296	appos	msps,stu2
R4551	T7299	T7296	punct	/,stu2
R4552	T7300	T7301	compound	ch,TOG
R4553	T7301	T7296	appos	TOG,stu2
R4554	T7302	T7301	punct	-,TOG
R4555	T7303	T7304	punct	[,5
R4556	T7304	T7289	parataxis	5,proteins
R4557	T7305	T7304	punct	",",5
R4558	T7306	T7304	appos	6,5
R4559	T7307	T7304	punct	",",5
R4560	T7308	T7304	appos	22,5
R4561	T7309	T7310	punct	-,24
R4562	T7310	T7308	prep	24,22
R4563	T7311	T7304	punct	],5
R4564	T7312	T7287	punct	", ",with
R4565	T7313	T7287	cc	and,with
R4566	T7314	T7287	conj	with,with
R4567	T7315	T7316	det	the,kinases
R4568	T7316	T7314	pobj	kinases,with
R4569	T7317	T7316	compound	Aurora,kinases
R4570	T7318	T7319	punct	[,25
R4571	T7319	T7316	parataxis	25,kinases
R4572	T7320	T7319	nummod	20,25
R4573	T7321	T7319	punct	",",25
R4574	T7322	T7319	nummod	21,25
R4575	T7323	T7319	punct	",",25
R4576	T7324	T7319	punct	],25
R4577	T7325	T7268	punct	.,known
R4578	T7327	T7328	det	These,interactions
R4579	T7328	T7329	nsubjpass	interactions,required
R4580	T7330	T7329	auxpass	are,required
R4581	T7331	T7329	prep	for,required
R4582	T7332	T7333	det	the,accumulation
R4583	T7333	T7331	pobj	accumulation,for
R4584	T7334	T7333	prep	of,accumulation
R4585	T7335	T7336	det	the,proteins
R4586	T7336	T7334	pobj	proteins,of
R4587	T7337	T7338	nmod	D,TACC
R4588	T7338	T7336	nmod	TACC,proteins
R4589	T7339	T7338	punct	-,TACC
R4590	T7340	T7338	punct	", ",TACC
R4591	T7341	T7338	conj	spc72,TACC
R4592	T7342	T7341	punct	", ",spc72
R4593	T7343	T7341	conj	ceTAC1,spc72
R4594	T7344	T7343	cc	and,ceTAC1
R4595	T7345	T7343	conj	TACC3,ceTAC1
R4596	T7346	T7333	prep	to,accumulation
R4597	T7347	T7348	det	the,centrosome
R4598	T7348	T7346	pobj	centrosome,to
R4599	T7349	T7350	punct	[,5
R4600	T7350	T7329	parataxis	5,required
R4601	T7351	T7350	punct	",",5
R4602	T7352	T7350	appos	6,5
R4603	T7353	T7350	punct	",",5
R4604	T7354	T7350	appos	22,5
R4605	T7355	T7356	punct	-,24
R4606	T7356	T7354	prep	24,22
R4607	T7357	T7350	punct	],5
R4608	T7358	T7329	punct	.,required
R4609	T7360	T7361	advmod	Hence,is
R4610	T7362	T7361	punct	", ",is
R4611	T7363	T7364	det	this,interaction
R4612	T7364	T7361	nsubj	interaction,is
R4613	T7365	T7364	amod	functional,interaction
R4614	T7366	T7364	prep	with,interaction
R4615	T7367	T7368	det	the,centrosome
R4616	T7368	T7366	pobj	centrosome,with
R4617	T7369	T7368	cc	and,centrosome
R4618	T7370	T7371	amod	mitotic,spindle
R4619	T7371	T7368	conj	spindle,centrosome
R4620	T7372	T7361	acomp	likely,is
R4621	T7373	T7374	aux	to,represent
R4622	T7374	T7372	xcomp	represent,likely
R4623	T7375	T7376	det	the,function
R4624	T7376	T7374	dobj	function,represent
R4625	T7377	T7376	amod	ancient,function
R4626	T7378	T7376	punct	", ",function
R4627	T7379	T7376	amod	conserved,function
R4628	T7380	T7376	prep	of,function
R4629	T7381	T7382	det	the,family
R4630	T7382	T7380	pobj	family,of
R4631	T7383	T7382	compound	TACC,family
R4632	T7384	T7361	punct	.,is
R4633	T7386	T7387	advmod	However,is
R4634	T7388	T7387	punct	", ",is
R4635	T7389	T7387	nsubj	it,is
R4636	T7390	T7387	acomp	apparent,is
R4637	T7391	T7392	mark	that,differ
R4638	T7392	T7387	ccomp	differ,is
R4639	T7393	T7394	det	the,proteins
R4640	T7394	T7392	nsubj	proteins,differ
R4641	T7395	T7394	amod	human,proteins
R4642	T7396	T7394	compound	TACC,proteins
R4643	T7397	T7392	advmod	also,differ
R4644	T7398	T7392	prep	in,differ
R4645	T7399	T7400	poss	their,ability
R4646	T7400	T7398	pobj	ability,in
R4647	T7401	T7402	aux	to,interact
R4648	T7402	T7400	acl	interact,ability
R4649	T7403	T7402	prep	with,interact
R4650	T7404	T7405	det	the,kinases
R4651	T7405	T7403	pobj	kinases,with
R4652	T7406	T7405	compound	Aurora,kinases
R4653	T7407	T7387	punct	.,is
R4654	T7409	T7410	prep	For,interact
R4655	T7411	T7409	pobj	instance,For
R4656	T7412	T7410	punct	", ",interact
R4657	T7413	T7410	nsubj	TACC1,interact
R4658	T7414	T7413	cc	and,TACC1
R4659	T7415	T7413	conj	TACC3,TACC1
R4660	T7416	T7410	prep	with,interact
R4661	T7417	T7418	compound	Aurora,A
R4662	T7418	T7419	compound	A,kinase
R4663	T7419	T7416	pobj	kinase,with
R4664	T7420	T7410	punct	", ",interact
R4665	T7421	T7422	mark	whereas,interacts
R4666	T7422	T7410	advcl	interacts,interact
R4667	T7423	T7422	nsubj	TACC2,interacts
R4668	T7424	T7422	prep	with,interacts
R4669	T7425	T7426	compound	Aurora,C
R4670	T7426	T7427	compound	C,kinase
R4671	T7427	T7424	pobj	kinase,with
R4672	T7428	T7429	punct	[,21
R4673	T7429	T7422	parataxis	21,interacts
R4674	T7430	T7429	punct	],21
R4675	T7431	T7410	punct	", ",interact
R4676	T7432	T7410	advcl	suggesting,interact
R4677	T7433	T7434	det	a,degree
R4678	T7434	T7432	dobj	degree,suggesting
R4679	T7435	T7434	prep	of,degree
R4680	T7436	T7437	amod	functional,specialization
R4681	T7437	T7435	pobj	specialization,of
R4682	T7438	T7434	prep	in,degree
R4683	T7439	T7440	det	the,derivatives
R4684	T7440	T7438	pobj	derivatives,in
R4685	T7441	T7440	prep	of,derivatives
R4686	T7442	T7443	det	the,TACC
R4687	T7443	T7441	pobj	TACC,of
R4688	T7444	T7443	amod	ancestral,TACC
R4689	T7445	T7443	compound	chordate,TACC
R4690	T7446	T7434	punct	", ",degree
R4691	T7447	T7434	prep	after,degree
R4692	T7448	T7449	det	the,radiation
R4693	T7449	T7447	pobj	radiation,after
R4694	T7450	T7449	prep	of,radiation
R4695	T7451	T7452	det	the,genes
R4696	T7452	T7450	pobj	genes,of
R4697	T7453	T7452	compound	vertebrate,genes
R4698	T7454	T7452	compound	TACC,genes
R4699	T7455	T7410	punct	.,interact
R4700	T7457	T7458	det	The,localization
R4701	T7458	T7459	nsubj	localization,suggests
R4702	T7460	T7458	prep	of,localization
R4703	T7461	T7462	det	the,proteins
R4704	T7462	T7460	pobj	proteins,of
R4705	T7463	T7462	compound	vertebrate,proteins
R4706	T7464	T7462	compound	TACC,proteins
R4707	T7465	T7458	prep	in,localization
R4708	T7466	T7467	det	the,nucleus
R4709	T7467	T7465	pobj	nucleus,in
R4710	T7468	T7467	compound	interphase,nucleus
R4711	T7469	T7470	punct	[,27
R4712	T7470	T7458	parataxis	27,localization
R4713	T7471	T7470	nummod	15,27
R4714	T7472	T7470	punct	",",27
R4715	T7473	T7470	nummod	26,27
R4716	T7474	T7470	punct	",",27
R4717	T7475	T7470	punct	],27
R4718	T7476	T7477	mark	that,have
R4719	T7477	T7459	ccomp	have,suggests
R4720	T7478	T7477	nsubj	they,have
R4721	T7479	T7480	amod	additional,functions
R4722	T7480	T7477	dobj	functions,have
R4723	T7481	T7480	prep	outside,functions
R4724	T7482	T7483	poss	their,role
R4725	T7483	T7481	pobj	role,outside
R4726	T7484	T7483	amod	ancient,role
R4727	T7485	T7483	prep	in,role
R4728	T7486	T7487	det	the,dynamics
R4729	T7487	T7485	pobj	dynamics,in
R4730	T7488	T7487	nmod	centrosome,dynamics
R4731	T7489	T7488	cc	and,centrosome
R4732	T7490	T7488	conj	microtubule,centrosome
R4733	T7491	T7459	punct	.,suggests
R4734	T7493	T7494	advmod	Thus,seems
R4735	T7495	T7494	punct	", ",seems
R4736	T7496	T7494	nsubj	it,seems
R4737	T7497	T7494	oprd	likely,seems
R4738	T7498	T7499	mark	that,integrated
R4739	T7499	T7494	ccomp	integrated,seems
R4740	T7500	T7501	compound	TACC,members
R4741	T7501	T7499	nsubj	members,integrated
R4742	T7502	T7501	compound	family,members
R4743	T7503	T7501	prep	in,members
R4744	T7504	T7503	pobj	protostomes,in
R4745	T7505	T7504	cc	and,protostomes
R4746	T7506	T7504	conj	deuterostomes,protostomes
R4747	T7507	T7499	aux	have,integrated
R4748	T7508	T7509	amod	new,functions
R4749	T7509	T7499	dobj	functions,integrated
R4750	T7510	T7509	amod	unique,functions
R4751	T7511	T7512	mark	as,acquired
R4752	T7512	T7499	advcl	acquired,integrated
R4753	T7513	T7514	det	the,genes
R4754	T7514	T7512	nsubj	genes,acquired
R4755	T7515	T7514	amod	evolving,genes
R4756	T7516	T7514	compound	TACC,genes
R4757	T7517	T7518	amod	additional,exons
R4758	T7518	T7512	dobj	exons,acquired
R4759	T7519	T7494	punct	.,seems
R4760	T7521	T7522	det	The,results
R4761	T7522	T7523	nsubj	results,provide
R4762	T7524	T7522	prep	of,results
R4763	T7525	T7526	det	the,analysis
R4764	T7526	T7524	pobj	analysis,of
R4765	T7527	T7526	nmod	pilot,analysis
R4766	T7528	T7529	amod	large,scale
R4767	T7529	T7526	nmod	scale,analysis
R4768	T7530	T7529	punct	-,scale
R4769	T7531	T7526	amod	proteomic,analysis
R4770	T7532	T7526	prep	in,analysis
R4771	T7533	T7534	compound	C.,elegans
R4772	T7534	T7532	pobj	elegans,in
R4773	T7535	T7534	cc	and,elegans
R4774	T7536	T7537	compound	D.,melanogaster
R4775	T7537	T7534	conj	melanogaster,elegans
R4776	T7538	T7539	amod	further,evidence
R4777	T7539	T7523	dobj	evidence,provide
R4778	T7540	T7539	amod	suggestive,evidence
R4779	T7541	T7539	prep	to,evidence
R4780	T7542	T7543	det	this,evolution
R4781	T7543	T7541	pobj	evolution,to
R4782	T7544	T7543	amod	functional,evolution
R4783	T7545	T7523	punct	.,provide
R4784	T7547	T7548	nmod	Yeast,analysis
R4785	T7548	T7551	nsubj	analysis,indicates
R4786	T7549	T7550	nummod	two,hybrid
R4787	T7550	T7548	compound	hybrid,analysis
R4788	T7552	T7553	mark	that,binds
R4789	T7553	T7551	ccomp	binds,indicates
R4790	T7554	T7553	nsubj	ceTAC,binds
R4791	T7555	T7553	advmod	directly,binds
R4792	T7556	T7553	prep	to,binds
R4793	T7557	T7558	compound	C.,lin15A
R4794	T7558	T7556	pobj	lin15A,to
R4795	T7559	T7558	compound	elegans,lin15A
R4796	T7560	T7558	punct	", ",lin15A
R4797	T7561	T7558	conj	lin36,lin15A
R4798	T7562	T7561	cc	and,lin36
R4799	T7563	T7561	conj	lin37,lin36
R4800	T7564	T7565	punct	[,28
R4801	T7565	T7551	parataxis	28,indicates
R4802	T7566	T7565	punct	],28
R4803	T7567	T7551	punct	.,indicates
R4804	T7569	T7570	det	These,proteins
R4805	T7570	T7571	nsubj	proteins,bridge
R4806	T7572	T7571	dobj	ceTAC,bridge
R4807	T7573	T7571	prep	to,bridge
R4808	T7574	T7575	amod	other,elements
R4809	T7575	T7573	pobj	elements,to
R4810	T7576	T7575	prep	of,elements
R4811	T7577	T7578	det	the,network
R4812	T7578	T7576	pobj	network,of
R4813	T7579	T7578	nmod	cytoskeleton,network
R4814	T7580	T7579	cc	and,cytoskeleton
R4815	T7581	T7579	conj	microtubule,cytoskeleton
R4816	T7582	T7573	punct	", ",to
R4817	T7583	T7584	advmod	as,as
R4818	T7584	T7573	cc	as,to
R4819	T7585	T7584	advmod	well,as
R4820	T7586	T7573	conj	to,to
R4821	T7587	T7586	pobj	components,to
R4822	T7588	T7587	prep	of,components
R4823	T7589	T7590	det	the,ribosome
R4824	T7590	T7588	pobj	ribosome,of
R4825	T7591	T7587	punct	", ",components
R4826	T7592	T7593	det	the,machinery
R4827	T7593	T7587	appos	machinery,components
R4828	T7594	T7595	nmod	histone,deacetylase
R4829	T7595	T7593	nmod	deacetylase,machinery
R4830	T7596	T7593	nmod	chromatin,machinery
R4831	T7597	T7596	amod	remodeling,chromatin
R4832	T7598	T7599	amod	such,as
R4833	T7599	T7593	prep	as,machinery
R4834	T7600	T7599	pobj	egr,as
R4835	T7601	T7600	punct	-,egr
R4836	T7602	T7600	nummod	1,egr
R4837	T7603	T7600	cc	and,egr
R4838	T7604	T7600	conj	lin,egr
R4839	T7605	T7604	punct	-,lin
R4840	T7606	T7604	nummod	53,lin
R4841	T7607	T7600	punct	(,egr
R4842	T7608	T7609	det	the,homologues
R4843	T7609	T7600	appos	homologues,egr
R4844	T7610	T7611	compound	C.,elegans
R4845	T7611	T7609	compound	elegans,homologues
R4846	T7612	T7609	prep	of,homologues
R4847	T7613	T7614	det	the,MTA
R4848	T7614	T7612	pobj	MTA,of
R4849	T7615	T7614	amod	human,MTA
R4850	T7616	T7614	punct	-,MTA
R4851	T7617	T7614	nummod	1,MTA
R4852	T7618	T7614	cc	and,MTA
R4853	T7619	T7614	conj	RbAP48,MTA
R4854	T7620	T7600	punct	),egr
R4855	T7621	T7586	punct	", ",to
R4856	T7622	T7586	cc	and,to
R4857	T7623	T7586	conj	to,to
R4858	T7624	T7625	compound	transcription,factors
R4859	T7625	T7623	pobj	factors,to
R4860	T7626	T7627	amod	such,as
R4861	T7627	T7625	prep	as,factors
R4862	T7628	T7629	det	the,homeobox
R4863	T7629	T7627	pobj	homeobox,as
R4864	T7630	T7629	compound	PAL1,homeobox
R4865	T7631	T7629	cc	and,homeobox
R4866	T7632	T7633	det	the,receptor
R4867	T7633	T7629	conj	receptor,homeobox
R4868	T7634	T7633	amod	nuclear,receptor
R4869	T7635	T7633	compound	hormone,receptor
R4870	T7636	T7633	appos	nhr,receptor
R4871	T7637	T7636	punct	-,nhr
R4872	T7638	T7636	nummod	86,nhr
R4873	T7639	T7640	punct	[,28
R4874	T7640	T7571	parataxis	28,bridge
R4875	T7641	T7640	punct	],28
R4876	T7642	T7643	punct	(,Fig.
R4877	T7643	T7571	parataxis	Fig.,bridge
R4878	T7644	T7643	nummod	6A,Fig.
R4879	T7645	T7643	punct	),Fig.
R4880	T7646	T7571	punct	.,bridge
R4881	T7648	T7649	advmod	Similarly,shown
R4882	T7650	T7649	punct	", ",shown
R4883	T7651	T7652	amod	large,scale
R4884	T7652	T7653	compound	scale,proteomics
R4885	T7653	T7649	nsubj	proteomics,shown
R4886	T7654	T7655	punct	[,29
R4887	T7655	T7653	parataxis	29,proteomics
R4888	T7656	T7655	punct	],29
R4889	T7657	T7649	aux	has,shown
R4890	T7658	T7659	mark	that,interacts
R4891	T7659	T7649	ccomp	interacts,shown
R4892	T7660	T7661	compound	Drosophila,TACC
R4893	T7661	T7659	nsubj	TACC,interacts
R4894	T7662	T7659	prep	with,interacts
R4895	T7663	T7664	nummod	two,proteins
R4896	T7664	T7662	pobj	proteins,with
R4897	T7665	T7664	punct	", ",proteins
R4898	T7666	T7667	det	the,protein
R4899	T7667	T7664	appos	protein,proteins
R4900	T7668	T7667	compound	RNA,protein
R4901	T7669	T7667	compound	binding,protein
R4902	T7670	T7667	appos	TBPH,protein
R4903	T7671	T7667	cc	and,protein
R4904	T7672	T7667	conj	CG14540,protein
R4905	T7673	T7674	punct	(,Fig.
R4906	T7674	T7664	parataxis	Fig.,proteins
R4907	T7675	T7674	nummod	6B,Fig.
R4908	T7676	T7674	punct	),Fig.
R4909	T7677	T7662	punct	", ",with
R4910	T7678	T7662	cc	and,with
R4911	T7679	T7680	advmod	thus,with
R4912	T7680	T7662	conj	with,with
R4913	T7681	T7680	advmod	indirectly,with
R4914	T7682	T7683	det	the,complex
R4915	T7683	T7680	pobj	complex,with
R4916	T7684	T7683	compound	Drosophila,complex
R4917	T7685	T7686	compound	SWI,SNF
R4918	T7686	T7683	compound	SNF,complex
R4919	T7687	T7686	punct	/,SNF
R4920	T7688	T7689	compound	chromatin,remodeling
R4921	T7689	T7683	compound	remodeling,complex
R4922	T7690	T7683	cc	and,complex
R4923	T7691	T7692	compound	DNA,damage
R4924	T7692	T7693	compound	damage,repair
R4925	T7693	T7694	compound	repair,machinery
R4926	T7694	T7683	conj	machinery,complex
R4927	T7695	T7649	punct	.,shown
R4928	T7697	T7698	advmod	Significantly,implicated
R4929	T7699	T7698	punct	", ",implicated
R4930	T7700	T7701	det	the,protein
R4943	T7713	T7712	amod	direct,interaction
R4944	T7714	T7712	prep	with,interaction
R4945	T7715	T7716	det	the,orthologue
R4946	T7716	T7714	pobj	orthologue,with
R4947	T7717	T7718	compound	C.,elegans
R4948	T7718	T7716	compound	elegans,orthologue
R4949	T7719	T7716	compound	BARD1,orthologue
R4950	T7720	T7721	punct	[,30
R4951	T7721	T7698	parataxis	30,implicated
R4952	T7722	T7721	punct	],30
R4953	T7723	T7698	punct	.,implicated
R4954	T7725	T7726	nsubjpass	It,noted
R4955	T7727	T7726	aux	should,noted
R4956	T7728	T7726	auxpass	be,noted
R4957	T7729	T7730	mark	that,missed
R4958	T7730	T7726	ccomp	missed,noted
R4959	T7731	T7732	det	a,number
R4960	T7732	T7730	nsubjpass	number,missed
R4961	T7733	T7732	prep	of,number
R4962	T7734	T7733	pobj	interactions,of
R4963	T7735	T7734	prep	with,interactions
R4964	T7736	T7737	det	the,proteins
R4965	T7737	T7735	pobj	proteins,with
R4966	T7738	T7737	compound	TACC,proteins
R4967	T7739	T7737	prep	from,proteins
R4968	T7740	T7741	det	these,organisms
R4969	T7741	T7739	pobj	organisms,from
R4970	T7742	T7730	aux	have,missed
R4971	T7743	T7730	advmod	probably,missed
R4972	T7744	T7730	auxpass	been,missed
R4973	T7745	T7730	agent	by,missed
R4974	T7746	T7747	det	these,methods
R4975	T7747	T7745	pobj	methods,by
R4976	T7748	T7749	amod	large,scale
R4977	T7749	T7747	compound	scale,methods
R4978	T7750	T7730	punct	", ",missed
R4979	T7751	T7730	prep	including,missed
R4980	T7752	T7753	det	the,interactions
R4981	T7753	T7751	pobj	interactions,including
R4982	T7754	T7755	advmod	well,documented
R4983	T7755	T7753	amod	documented,interactions
R4984	T7756	T7753	amod	direct,interactions
R4985	T7757	T7753	prep	with,interactions
R4986	T7758	T7759	det	the,kinases
R4987	T7759	T7757	pobj	kinases,with
R4988	T7760	T7759	compound	aurora,kinases
R4989	T7761	T7759	cc	and,kinases
R4990	T7762	T7763	det	the,family
R4991	T7763	T7759	conj	family,kinases
R4992	T7764	T7763	nmod	stu2,family
R4993	T7765	T7764	punct	/,stu2
R4994	T7766	T7764	appos	msps,stu2
R4995	T7767	T7764	punct	/,stu2
R4996	T7768	T7769	compound	ch,TOG
R4997	T7769	T7764	appos	TOG,stu2
R4998	T7770	T7769	punct	-,TOG
R4999	T7771	T7726	punct	.,noted
R5032	T7807	T7808	amod	Phylogenetic,profiling
R5033	T7808	T7809	nsubj	profiling,suggests
R5034	T7810	T7808	prep	from,profiling
R5035	T7811	T7812	det	these,maps
R5036	T7812	T7810	pobj	maps,from
R5037	T7813	T7812	compound	interaction,maps
R5038	T7814	T7815	nummod	two,sets
R5039	T7815	T7809	dobj	sets,suggests
R5040	T7816	T7815	amod	similar,sets
R5041	T7817	T7815	prep	of,sets
R5042	T7818	T7819	amod	predicted,interactions
R5043	T7819	T7817	pobj	interactions,of
R5044	T7820	T7815	prep	for,sets
R5045	T7821	T7822	compound	vertebrate,TACCs
R5046	T7822	T7820	pobj	TACCs,for
R5047	T7823	T7824	punct	(,6C
R5048	T7824	T7809	parataxis	6C,suggests
R5049	T7825	T7824	nmod	Fig.,6C
R5050	T7826	T7824	cc	and,6C
R5051	T7827	T7824	conj	6D,6C
R5052	T7828	T7824	punct	),6C
R5053	T7829	T7809	punct	.,suggests
R5054	T7831	T7832	advmod	Strikingly,have
R5055	T7833	T7832	punct	", ",have
R5056	T7834	T7832	advmod	however,have
R5057	T7835	T7832	punct	", ",have
R5058	T7836	T7837	det	the,proteins
R5059	T7837	T7832	nsubj	proteins,have
R5060	T7838	T7839	compound	C.,elegans
R5061	T7839	T7840	npadvmod	elegans,specific
R5062	T7840	T7837	amod	specific,proteins
R5063	T7841	T7837	appos	lin15A,proteins
R5064	T7842	T7841	punct	", ",lin15A
R5065	T7843	T7841	conj	lin36,lin15A
R5066	T7844	T7843	cc	and,lin36
R5067	T7845	T7843	conj	lin37,lin36
R5068	T7846	T7832	aux	do,have
R5069	T7847	T7832	neg	not,have
R5070	T7848	T7849	advmod	readily,discernible
R5071	T7849	T7850	amod	discernible,homologues
R5072	T7850	T7832	dobj	homologues,have
R5073	T7851	T7832	prep	in,have
R5074	T7852	T7851	pobj	vertebrates,in
R5075	T7853	T7852	cc	or,vertebrates
R5076	T7854	T7852	conj	Drosophila,vertebrates
R5077	T7855	T7832	punct	", ",have
R5078	T7856	T7857	mark	although,suggest
R5079	T7857	T7832	advcl	suggest,have
R5080	T7858	T7859	det	the,presence
R5081	T7859	T7857	nsubj	presence,suggest
R5082	T7860	T7859	prep	of,presence
R5083	T7861	T7862	det	a,domain
R5084	T7862	T7860	pobj	domain,of
R5085	T7863	T7864	compound	zinc,finger
R5086	T7864	T7862	compound	finger,domain
R5087	T7865	T7859	prep	in,presence
R5088	T7866	T7865	pobj	lin36,in
R5089	T7867	T7857	aux	may,suggest
R5090	T7868	T7869	mark	that,involved
R5091	T7869	T7857	ccomp	involved,suggest
R5092	T7870	T7871	det	this,protein
R5093	T7871	T7869	nsubjpass	protein,involved
R5094	T7872	T7869	auxpass	is,involved
R5095	T7873	T7869	advmod	directly,involved
R5096	T7874	T7869	prep	in,involved
R5097	T7875	T7874	pobj	transcription,in
R5098	T7876	T7869	cc	or,involved
R5099	T7877	T7869	conj	perform,involved
R5100	T7878	T7879	det	an,role
R5101	T7879	T7877	dobj	role,perform
R5102	T7880	T7879	compound	adaptor,role
R5103	T7881	T7879	amod	similar,role
R5104	T7882	T7881	prep	to,similar
R5105	T7883	T7884	npadvmod	LIM,containing
R5106	T7884	T7885	amod	containing,proteins
R5107	T7885	T7882	pobj	proteins,to
R5108	T7886	T7832	punct	.,have
R5109	T7888	T7889	prep	For,corresponds
R5110	T7890	T7891	det	the,proteins
R5111	T7891	T7888	pobj	proteins,For
R5112	T7892	T7893	npadvmod	DTACC,interacting
R5113	T7893	T7891	amod	interacting,proteins
R5114	T7894	T7889	punct	", ",corresponds
R5115	T7895	T7889	nsubj	TBPH,corresponds
R5116	T7896	T7889	prep	to,corresponds
R5117	T7897	T7896	pobj	TDP43,to
R5118	T7898	T7897	punct	", ",TDP43
R5119	T7899	T7900	det	a,protein
R5120	T7900	T7897	appos	protein,TDP43
R5121	T7901	T7900	acl	implicated,protein
R5122	T7902	T7901	prep	in,implicated
R5123	T7903	T7904	amod	transcriptional,regulation
R5124	T7904	T7902	pobj	regulation,in
R5125	T7905	T7904	cc	and,regulation
R5126	T7906	T7904	conj	splicing,regulation
R5127	T7907	T7908	punct	[,32
R5128	T7908	T7889	parataxis	32,corresponds
R5129	T7909	T7908	nummod	31,32
R5130	T7910	T7908	punct	",",32
R5131	T7911	T7908	punct	],32
R5132	T7912	T7889	punct	.,corresponds
R5133	T7914	T7915	advmod	However,is
R5134	T7916	T7915	punct	", ",is
R5135	T7917	T7918	det	the,assignment
R5136	T7918	T7915	nsubj	assignment,is
R5137	T7919	T7918	prep	of,assignment
R5138	T7920	T7921	det	the,homologue
R5139	T7921	T7919	pobj	homologue,of
R5140	T7922	T7921	amod	human,homologue
R5141	T7923	T7921	prep	of,homologue
R5142	T7924	T7923	pobj	CG14540,of
R5143	T7925	T7926	advmod	less,clear
R5144	T7926	T7915	acomp	clear,is
R5145	T7927	T7915	punct	", ",is
R5146	T7928	T7915	prep	with,is
R5147	T7929	T7930	det	the,matches
R5148	T7930	T7932	nsubj	matches,corresponding
R5149	T7931	T7930	amod	closest,matches
R5150	T7932	T7928	pcomp	corresponding,with
R5151	T7933	T7930	prep	in,matches
R5152	T7934	T7935	det	the,databases
R5153	T7935	T7933	pobj	databases,in
R5154	T7936	T7935	amod	human,databases
R5155	T7937	T7932	prep	to,corresponding
R5156	T7938	T7939	npadvmod	glutamine,rich
R5157	T7939	T7940	amod	rich,factors
R5158	T7940	T7937	pobj	factors,to
R5159	T7941	T7940	compound	transcription,factors
R5160	T7942	T7943	amod	such,as
R5161	T7943	T7940	prep	as,factors
R5162	T7944	T7943	pobj	CREB,as
R5163	T7945	T7944	cc	and,CREB
R5164	T7946	T7947	det	the,factor
R5165	T7947	T7944	conj	factor,CREB
R5166	T7948	T7949	compound	G,box
R5167	T7949	T7947	compound	box,factor
R5168	T7950	T7949	punct	-,box
R5169	T7951	T7947	compound	binding,factor
R5170	T7952	T7915	punct	.,is
R5177	T8333	T8332	prep	of,Comparison
R5178	T8334	T8333	pobj	modeled,of
R5179	T8335	T8332	prep	with,Comparison
R5180	T8336	T8337	advmod	experimentally,defined
R5181	T8337	T8335	pobj	defined,with
R5182	T8338	T8332	appos	interactions,Comparison
R5183	T8339	T8338	prep	of,interactions
R5184	T8340	T8341	det	the,proteins
R5185	T8341	T8339	pobj	proteins,of
R5186	T8342	T8341	compound	vertebrate,proteins
R5187	T8343	T8341	compound	TACC,proteins
R5188	T8345	T8346	det	The,data
R5189	T8346	T8348	nsubj	data,is
R5190	T8347	T8346	compound	interaction,data
R5191	T8348	T8353	ccomp	is,beginning
R5192	T8349	T8346	prep	for,data
R5193	T8350	T8351	det	the,TACCs
R5194	T8351	T8349	pobj	TACCs,for
R5195	T8352	T8351	compound	vertebrate,TACCs
R5196	T8354	T8355	advmod	relatively,limited
R5197	T8355	T8348	acomp	limited,is
R5198	T8356	T8353	punct	;,beginning
R5199	T8357	T8353	advmod	however,beginning
R5200	T8358	T8353	punct	", ",beginning
R5201	T8359	T8360	compound	interaction,networks
R5202	T8360	T8353	nsubj	networks,beginning
R5203	T8361	T8353	aux	are,beginning
R5204	T8362	T8353	advmod	now,beginning
R5205	T8363	T8364	aux	to,emerge
R5206	T8364	T8353	xcomp	emerge,beginning
R5207	T8365	T8353	punct	.,beginning
R5208	T8367	T8368	det	The,results
R5209	T8368	T8369	nsubj	results,indicate
R5210	T8370	T8368	prep	of,results
R5211	T8371	T8372	poss	our,analysis
R5212	T8372	T8370	pobj	analysis,of
R5213	T8373	T8372	amod	functional,analysis
R5214	T8374	T8368	punct	", ",results
R5215	T8375	T8376	advmod	as,as
R5216	T8376	T8368	cc	as,results
R5217	T8377	T8376	advmod	well,as
R5218	T8378	T8379	amod	other,data
R5219	T8379	T8368	conj	data,results
R5220	T8380	T8379	amod	published,data
R5221	T8381	T8369	advmod	clearly,indicate
R5222	T8382	T8383	mark	that,interact
R5223	T8383	T8369	ccomp	interact,indicate
R5224	T8384	T8385	det	the,TACCs
R5225	T8385	T8383	nsubj	TACCs,interact
R5226	T8386	T8385	compound	vertebrate,TACCs
R5227	T8387	T8383	prep	with,interact
R5228	T8388	T8387	pobj	proteins,with
R5229	T8389	T8390	dep	that,divided
R5230	T8390	T8388	relcl	divided,proteins
R5231	T8391	T8390	aux	can,divided
R5232	T8392	T8390	auxpass	be,divided
R5233	T8393	T8390	prep	into,divided
R5234	T8394	T8395	nummod	two,categories
R5235	T8395	T8393	pobj	categories,into
R5236	T8396	T8395	amod	broad,categories
R5237	T8397	T8369	punct	: ,indicate
R5238	T8398	T8399	meta	1,proteins
R5239	T8401	T8398	punct	),1
R5240	T8402	T8399	prep	with,proteins
R5241	T8403	T8402	pobj	roles,with
R5242	T8404	T8403	prep	in,roles
R5243	T8405	T8406	npadvmod	centrosome,mitotic
R5244	T8406	T8408	amod	mitotic,spindle
R5245	T8407	T8406	punct	/,mitotic
R5246	T8408	T8409	compound	spindle,dynamics
R5247	T8409	T8404	pobj	dynamics,in
R5248	T8410	T8399	punct	", ",proteins
R5249	T8411	T8399	cc	and,proteins
R5250	T8412	T8413	meta	2,proteins
R5251	T8413	T8399	conj	proteins,proteins
R5252	T8414	T8412	punct	),2
R5253	T8415	T8413	acl	involved,proteins
R5254	T8416	T8415	prep	in,involved
R5255	T8417	T8418	compound	gene,regulation
R5256	T8418	T8416	pobj	regulation,in
R5257	T8419	T8415	punct	", ",involved
R5258	T8420	T8421	preconj	either,at
R5259	T8421	T8415	prep	at,involved
R5260	T8422	T8423	det	the,level
R5261	T8423	T8421	pobj	level,at
R5262	T8424	T8423	prep	of,level
R5263	T8425	T8424	pobj	transcription,of
R5264	T8426	T8425	punct	", ",transcription
R5265	T8427	T8425	cc	or,transcription
R5266	T8428	T8429	amod	subsequent,processing
R5267	T8429	T8425	conj	processing,transcription
R5268	T8430	T8429	compound	RNA,processing
R5269	T8431	T8429	cc	and,processing
R5270	T8432	T8429	conj	translation,processing
R5271	T8433	T8434	punct	[,3
R5272	T8434	T8415	parataxis	3,involved
R5273	T8435	T8434	punct	",",3
R5274	T8436	T8434	appos	5,3
R5275	T8437	T8438	punct	-,7
R5276	T8438	T8436	prep	7,5
R5277	T8439	T8434	punct	",",3
R5278	T8440	T8434	appos	15,3
R5279	T8441	T8434	punct	",",3
R5280	T8442	T8434	appos	19,3
R5281	T8443	T8444	punct	-,21
R5282	T8444	T8442	prep	21,19
R5283	T8445	T8434	punct	",",3
R5284	T8446	T8434	appos	24,3
R5285	T8447	T8434	punct	",",3
R5286	T8448	T8434	appos	25,3
R5287	T8449	T8434	punct	",",3
R5288	T8450	T8434	appos	33,3
R5289	T8451	T8434	punct	",",3
R5290	T8452	T8434	appos	34,3
R5291	T8453	T8434	punct	],3
R5292	T8454	T8413	punct	.,proteins
R5293	T8456	T8457	nsubj	Many,appear
R5294	T8458	T8456	prep	of,Many
R5295	T8459	T8460	det	these,proteins
R5296	T8460	T8458	pobj	proteins,of
R5297	T8461	T8457	aux	do,appear
R5298	T8462	T8457	neg	not,appear
R5299	T8463	T8464	aux	to,interact
R5300	T8464	T8457	xcomp	interact,appear
R5301	T8465	T8464	advmod	directly,interact
R5302	T8466	T8464	prep	with,interact
R5303	T8467	T8468	det	the,TACCs
R5304	T8468	T8466	pobj	TACCs,with
R5305	T8469	T8468	compound	protostome,TACCs
R5306	T8470	T8457	punct	", ",appear
R5307	T8471	T8457	cc	but,appear
R5308	T8472	T8473	aux	would,expected
R5309	T8473	T8457	conj	expected,appear
R5310	T8474	T8473	auxpass	be,expected
R5311	T8475	T8476	aux	to,be
R5312	T8476	T8473	xcomp	be,expected
R5313	T8477	T8476	prep	in,be
R5314	T8478	T8479	det	the,complex
R5315	T8479	T8477	pobj	complex,in
R5316	T8480	T8479	amod	same,complex
R5317	T8481	T8479	compound	protein,complex
R5318	T8482	T8483	punct	(,6D
R5319	T8483	T8473	parataxis	6D,expected
R5320	T8484	T8483	nmod	Fig.,6D
R5321	T8485	T8483	nummod	6C,6D
R5322	T8486	T8483	punct	",",6D
R5323	T8487	T8483	punct	),6D
R5324	T8488	T8457	punct	.,appear
R5325	T8490	T8491	amod	Significant,analysis
R5326	T8491	T8492	nsubjpass	analysis,published
R5327	T8493	T8491	prep	of,analysis
R5328	T8494	T8495	det	the,association
R5329	T8495	T8493	pobj	association,of
R5330	T8496	T8495	prep	of,association
R5331	T8497	T8498	det	the,TACCs
R5332	T8498	T8496	pobj	TACCs,of
R5333	T8499	T8495	prep	with,association
R5334	T8500	T8501	det	the,centrosome
R5335	T8501	T8499	pobj	centrosome,with
R5336	T8502	T8495	cc	and,association
R5337	T8503	T8504	det	the,dynamics
R5338	T8504	T8495	conj	dynamics,association
R5339	T8505	T8504	prep	of,dynamics
R5340	T8506	T8507	amod	mitotic,spindle
R5341	T8507	T8508	compound	spindle,assembly
R5342	T8508	T8505	pobj	assembly,of
R5343	T8509	T8491	prep	from,analysis
R5344	T8510	T8509	pobj	yeast,from
R5345	T8511	T8509	prep	to,from
R5346	T8512	T8511	pobj	humans,to
R5347	T8513	T8492	aux	has,published
R5348	T8514	T8492	auxpass	been,published
R5349	T8515	T8516	punct	[,5
R5350	T8516	T8492	parataxis	5,published
R5351	T8517	T8516	punct	",",5
R5352	T8518	T8516	appos	6,5
R5353	T8519	T8516	punct	",",5
R5354	T8520	T8516	appos	21,5
R5355	T8521	T8522	punct	-,24
R5356	T8522	T8520	prep	24,21
R5357	T8523	T8516	punct	],5
R5358	T8524	T8492	punct	.,published
R5359	T8526	T8527	prep	From,seems
R5360	T8528	T8529	det	this,analysis
R5361	T8529	T8526	pobj	analysis,From
R5362	T8530	T8527	punct	", ",seems
R5363	T8531	T8527	nsubj	it,seems
R5364	T8532	T8527	oprd	likely,seems
R5365	T8533	T8534	mark	that,retained
R5366	T8534	T8527	ccomp	retained,seems
R5367	T8535	T8536	det	the,protein
R5368	T8536	T8534	nsubj	protein,retained
R5369	T8537	T8536	compound	vertebrate,protein
R5370	T8538	T8536	compound	TACC3,protein
R5371	T8539	T8534	aux	has,retained
R5372	T8540	T8541	det	this,function
R5373	T8541	T8534	dobj	function,retained
R5374	T8542	T8541	amod	direct,function
R5375	T8543	T8541	amod	ancestral,function
R5376	T8544	T8527	punct	", ",seems
R5377	T8545	T8527	prep	based,seems
R5378	T8546	T8545	prep	upon,based
R5379	T8547	T8548	poss	its,location
R5380	T8548	T8546	pobj	location,upon
R5381	T8549	T8548	prep	in,location
R5382	T8550	T8551	det	these,structures
R5383	T8551	T8549	pobj	structures,in
R5384	T8552	T8548	prep	during,location
R5385	T8553	T8552	pobj	mitosis,during
R5386	T8554	T8555	punct	[,27
R5387	T8555	T8548	parataxis	27,location
R5388	T8556	T8555	punct	],27
R5389	T8557	T8548	punct	", ",location
R5390	T8558	T8559	poss	its,interaction
R5391	T8559	T8548	conj	interaction,location
R5392	T8560	T8559	amod	strong,interaction
R5393	T8561	T8559	prep	with,interaction
R5394	T8562	T8563	compound	Aurora,A
R5395	T8563	T8561	pobj	A,with
R5396	T8564	T8563	compound	Kinase,A
R5397	T8565	T8559	punct	", ",interaction
R5398	T8566	T8559	cc	and,interaction
R5399	T8567	T8568	det	the,observation
R5400	T8568	T8559	conj	observation,interaction
R5401	T8569	T8570	mark	that,is
R5402	T8570	T8568	acl	is,observation
R5403	T8571	T8570	nsubj	it,is
R5404	T8572	T8573	det	the,protein
R5405	T8573	T8570	attr	protein,is
R5406	T8574	T8573	advmod	only,protein
R5407	T8575	T8573	amod	human,protein
R5408	T8576	T8573	compound	TACC,protein
R5409	T8577	T8573	acl	phosphorylated,protein
R5410	T8578	T8577	agent	by,phosphorylated
R5411	T8579	T8580	det	this,enzyme
R5412	T8580	T8578	pobj	enzyme,by
R5413	T8581	T8582	punct	[,21
R5414	T8582	T8568	parataxis	21,observation
R5415	T8583	T8582	punct	],21
R5416	T8584	T8527	punct	.,seems
R5417	T8586	T8587	advmod	However,suggests
R5418	T8588	T8587	punct	", ",suggests
R5419	T8589	T8590	det	the,variability
R5420	T8590	T8587	nsubj	variability,suggests
R5421	T8591	T8590	prep	of,variability
R5422	T8592	T8593	det	the,domain
R5423	T8593	T8591	pobj	domain,of
R5424	T8594	T8593	amod	central,domain
R5425	T8595	T8593	prep	of,domain
R5426	T8596	T8597	det	the,orthologues
R5427	T8597	T8595	pobj	orthologues,of
R5428	T8598	T8597	compound	vertebrate,orthologues
R5429	T8599	T8587	punct	", ",suggests
R5430	T8600	T8601	mark	that,acquired
R5431	T8601	T8587	ccomp	acquired,suggests
R5432	T8602	T8601	nsubj	TACC3,acquired
R5433	T8603	T8601	aux	may,acquired
R5434	T8604	T8601	advmod	also,acquired
R5435	T8605	T8601	aux	have,acquired
R5436	T8606	T8607	amod	additional,functions
R5437	T8607	T8601	dobj	functions,acquired
R5438	T8608	T8606	punct	", ",additional
R5439	T8609	T8606	cc	and,additional
R5440	T8610	T8611	prep	in,specific
R5441	T8611	T8606	conj	specific,additional
R5442	T8612	T8613	det	some,instances
R5443	T8613	T8610	pobj	instances,in
R5444	T8614	T8611	punct	", ",specific
R5445	T8615	T8611	npadvmod	species,specific
R5446	T8616	T8611	punct	-,specific
R5447	T8617	T8587	punct	.,suggests
R5448	T8619	T8620	prep	For,acquired
R5449	T8621	T8619	pobj	instance,For
R5450	T8622	T8620	punct	", ",acquired
R5451	T8623	T8620	prep	in,acquired
R5452	T8624	T8625	compound	X.,laevis
R5453	T8625	T8623	pobj	laevis,in
R5454	T8626	T8620	punct	", ",acquired
R5455	T8627	T8628	det	the,protein
R5456	T8628	T8620	nsubj	protein,acquired
R5457	T8629	T8628	compound	maskin,protein
R5458	T8630	T8620	aux	has,acquired
R5459	T8631	T8632	det	a,site
R5460	T8632	T8620	dobj	site,acquired
R5461	T8633	T8632	compound	binding,site
R5462	T8634	T8632	prep	for,site
R5463	T8635	T8636	det	the,protein
R5464	T8636	T8634	pobj	protein,for
R5465	T8637	T8636	compound	eIF4E,protein
R5466	T8638	T8632	punct	", ",site
R5467	T8639	T8632	cc	and,site
R5468	T8640	T8641	advmod	thus,function
R5469	T8641	T8632	conj	function,site
R5470	T8642	T8641	det	a,function
R5471	T8643	T8641	prep	in,function
R5472	T8644	T8645	det	the,control
R5473	T8645	T8643	pobj	control,in
R5474	T8646	T8645	amod	coordinated,control
R5475	T8647	T8645	prep	of,control
R5476	T8648	T8647	pobj	polyadenylation,of
R5477	T8649	T8648	cc	and,polyadenylation
R5478	T8650	T8648	conj	translation,polyadenylation
R5479	T8651	T8641	prep	in,function
R5480	T8652	T8653	det	the,oocyte
R5481	T8653	T8651	pobj	oocyte,in
R5482	T8654	T8653	compound	Xenopus,oocyte
R5483	T8655	T8656	punct	[,35
R5484	T8656	T8620	parataxis	35,acquired
R5485	T8657	T8656	nummod	8,35
R5486	T8658	T8656	punct	",",35
R5487	T8659	T8656	punct	],35
R5488	T8660	T8620	punct	.,acquired
R5489	T8662	T8663	det	A,study
R5490	T8663	T8665	nsubj	study,suggested
R5491	T8664	T8663	amod	recent,study
R5492	T8665	T8667	ccomp	suggested,is
R5493	T8666	T8665	aux	has,suggested
R5494	T8668	T8669	mark	that,be
R5495	T8669	T8665	ccomp	be,suggested
R5496	T8670	T8671	det	this,function
R5497	T8671	T8669	nsubj	function,be
R5498	T8672	T8669	aux	may,be
R5499	T8673	T8669	acomp	unique,be
R5500	T8674	T8673	prep	to,unique
R5501	T8675	T8674	pobj	maskin,to
R5502	T8676	T8667	punct	: ,is
R5503	T8677	T8678	mark	although,is
R5504	T8678	T8667	advcl	is,is
R5505	T8679	T8678	nsubj	it,is
R5506	T8680	T8678	acomp	unclear,is
R5507	T8681	T8682	mark	whether,interact
R5508	T8682	T8678	ccomp	interact,is
R5509	T8683	T8684	det	the,proteins
R5510	T8684	T8682	nsubj	proteins,interact
R5511	T8685	T8684	amod	other,proteins
R5512	T8686	T8684	compound	vertebrate,proteins
R5513	T8687	T8684	compound	TACC3,proteins
R5514	T8688	T8682	prep	with,interact
R5515	T8689	T8690	det	the,complex
R5516	T8690	T8688	pobj	complex,with
R5517	T8691	T8692	compound	eIF4E,CPEB
R5518	T8692	T8690	compound	CPEB,complex
R5519	T8693	T8692	punct	/,CPEB
R5520	T8694	T8667	punct	", ",is
R5521	T8695	T8696	det	the,isoform
R5522	T8696	T8667	nsubj	isoform,is
R5523	T8697	T8696	amod	human,isoform
R5524	T8698	T8696	compound	TACC1A,isoform
R5525	T8699	T8667	acomp	unable,is
R5526	T8700	T8701	aux	to,interact
R5527	T8701	T8699	xcomp	interact,unable
R5528	T8702	T8701	prep	with,interact
R5529	T8703	T8704	det	the,complex
R5530	T8704	T8702	pobj	complex,with
R5531	T8705	T8706	compound	eIF4E,CPEB
R5532	T8706	T8704	compound	CPEB,complex
R5533	T8707	T8706	punct	/,CPEB
R5534	T8708	T8667	punct	.,is
R5535	T8710	T8711	advmod	Instead,evolved
R5536	T8712	T8711	punct	", ",evolved
R5537	T8713	T8714	det	some,isoforms
R5538	T8714	T8711	nsubj	isoforms,evolved
R5539	T8715	T8714	compound	TACC1,isoforms
R5540	T8716	T8711	aux	have,evolved
R5541	T8717	T8718	det	a,function
R5542	T8718	T8711	dobj	function,evolved
R5543	T8719	T8718	amod	related,function
R5544	T8720	T8719	punct	", ",related
R5545	T8721	T8719	cc	but,related
R5546	T8722	T8719	conj	distinct,related
R5547	T8723	T8711	prep	by,evolved
R5548	T8724	T8725	advmod	directly,interacting
R5549	T8725	T8723	pcomp	interacting,by
R5550	T8726	T8725	prep	with,interacting
R5551	T8727	T8726	pobj	elements,with
R5552	T8728	T8727	prep	of,elements
R5553	T8729	T8730	det	the,machinery
R5554	T8730	T8728	pobj	machinery,of
R5555	T8731	T8732	nmod	RNA,splicing
R5556	T8732	T8730	nmod	splicing,machinery
R5557	T8733	T8732	cc	and,splicing
R5558	T8734	T8732	conj	transport,splicing
R5559	T8735	T8736	punct	[,19
R5560	T8736	T8711	parataxis	19,evolved
R5561	T8737	T8736	punct	],19
R5562	T8738	T8711	punct	.,evolved
R5563	T8740	T8741	aux	To,characterize
R5564	T8741	T8743	advcl	characterize,used
R5565	T8742	T8741	advmod	further,characterize
R5566	T8744	T8745	det	the,functions
R5567	T8745	T8741	dobj	functions,characterize
R5568	T8746	T8745	amod	evolving,functions
R5569	T8747	T8745	prep	of,functions
R5570	T8748	T8749	det	the,proteins
R5571	T8749	T8747	pobj	proteins,of
R5572	T8750	T8749	compound	TACC,proteins
R5573	T8751	T8743	punct	", ",used
R5574	T8752	T8743	nsubj	we,used
R5575	T8753	T8743	aux	have,used
R5576	T8754	T8755	det	an,method
R5577	T8755	T8743	dobj	method,used
R5578	T8756	T8755	amod	unbiased,method
R5579	T8757	T8755	nmod	yeast,method
R5580	T8758	T8759	nummod	two,hybrid
R5581	T8759	T8755	compound	hybrid,method
R5582	T8760	T8755	compound	screening,method
R5583	T8761	T8762	aux	to,identify
R5584	T8762	T8743	advcl	identify,used
R5585	T8763	T8762	dobj	proteins,identify
R5586	T8764	T8765	dep	that,bind
R5587	T8765	T8763	relcl	bind,proteins
R5588	T8766	T8765	prep	to,bind
R5589	T8767	T8768	det	the,proteins
R5590	T8768	T8766	pobj	proteins,to
R5591	T8769	T8768	amod	human,proteins
R5592	T8770	T8768	compound	TACC,proteins
R5593	T8771	T8772	punct	[,34
R5594	T8772	T8743	parataxis	34,used
R5595	T8773	T8772	nummod	3,34
R5596	T8774	T8772	punct	",",34
R5597	T8775	T8772	punct	],34
R5598	T8776	T8743	punct	.,used
R5599	T8778	T8779	prep	In,identified
R5600	T8780	T8781	det	a,screen
R5601	T8781	T8778	pobj	screen,In
R5602	T8782	T8781	prep	of,screen
R5603	T8783	T8784	det	a,library
R5604	T8784	T8782	pobj	library,of
R5605	T8785	T8784	nmod	MATCHMAKER,library
R5606	T8786	T8787	amod	fetal,brain
R5607	T8787	T8784	compound	brain,library
R5608	T8788	T8789	punct	(,Clontech
R5609	T8789	T8784	parataxis	Clontech,library
R5610	T8790	T8789	compound	BD,Clontech
R5611	T8791	T8789	compound	Biosciences,Clontech
R5612	T8792	T8789	punct	),Clontech
R5613	T8793	T8779	punct	", ",identified
R5614	T8794	T8779	prep	in,identified
R5615	T8795	T8794	pobj	addition,in
R5616	T8796	T8795	prep	to,addition
R5617	T8797	T8796	pcomp	isolating,to
R5618	T8798	T8799	det	the,acetyltransferase
R5619	T8799	T8797	dobj	acetyltransferase,isolating
R5620	T8800	T8799	compound	histone,acetyltransferase
R5621	T8801	T8799	appos	hGCN5L2,acetyltransferase
R5622	T8802	T8803	punct	[,34
R5623	T8803	T8797	parataxis	34,isolating
R5624	T8804	T8803	punct	],34
R5625	T8805	T8779	punct	", ",identified
R5626	T8806	T8779	nsubj	we,identified
R5627	T8807	T8779	advmod	also,identified
R5628	T8808	T8809	det	the,isoform
R5629	T8809	T8779	dobj	isoform,identified
R5630	T8810	T8809	compound	β3,isoform
R5631	T8811	T8809	prep	of,isoform
R5632	T8812	T8813	compound	retinoid,X
R5633	T8813	T8815	compound	X,β
R5634	T8814	T8813	punct	-,X
R5635	T8815	T8811	pobj	β,of
R5636	T8816	T8815	compound	receptor,β
R5637	T8817	T8779	prep	as,identified
R5638	T8818	T8819	det	a,protein
R5639	T8819	T8817	pobj	protein,as
R5640	T8820	T8821	dep	that,interacts
R5641	T8821	T8819	relcl	interacts,protein
R5642	T8822	T8821	prep	with,interacts
R5643	T8823	T8824	det	the,domain
R5644	T8824	T8822	pobj	domain,with
R5645	T8825	T8824	compound	TACC,domain
R5646	T8826	T8824	prep	of,domain
R5647	T8827	T8826	pobj	TACC2,of
R5648	T8828	T8779	punct	.,identified
R5649	T8830	T8831	mark	As,shown
R5650	T8831	T8832	advcl	shown,confirmed
R5651	T8833	T8831	prep	in,shown
R5652	T8834	T8833	pobj	Fig.,in
R5653	T8835	T8834	nummod	7,Fig.
R5654	T8836	T8832	punct	", ",confirmed
R5655	T8837	T8838	det	this,interaction
R5656	T8838	T8832	nsubjpass	interaction,confirmed
R5657	T8839	T8832	auxpass	is,confirmed
R5658	T8840	T8841	advmod	in,vitro
R5659	T8841	T8832	advmod	vitro,confirmed
R5660	T8842	T8832	prep	by,confirmed
R5661	T8843	T8844	npadvmod	GST,pull
R5662	T8844	T8846	amod	pull,analysis
R5663	T8845	T8844	punct	-,pull
R5664	T8846	T8842	pobj	analysis,by
R5665	T8847	T8844	prt	down,pull
R5666	T8848	T8832	punct	.,confirmed
R5667	T8850	T8851	advmod	Significantly,is
R5668	T8852	T8851	punct	", ",is
R5669	T8853	T8851	nsubj	RXRβ,is
R5670	T8854	T8855	det	a,family
R5671	T8855	T8851	attr	family,is
R5672	T8856	T8855	amod	close,family
R5673	T8857	T8855	amod	relative,family
R5674	T8858	T8855	prep	of,family
R5675	T8859	T8860	det	the,receptor
R5676	T8860	T8858	pobj	receptor,of
R5677	T8861	T8860	amod	nuclear,receptor
R5678	T8862	T8860	compound	hormone,receptor
R5679	T8863	T8860	punct	", ",receptor
R5680	T8864	T8860	appos	nhr,receptor
R5681	T8865	T8864	punct	-,nhr
R5682	T8866	T8864	nummod	86,nhr
R5683	T8867	T8860	punct	", ",receptor
R5684	T8868	T8860	prep	from,receptor
R5685	T8869	T8870	compound	C.,elegans
R5686	T8870	T8868	pobj	elegans,from
R5687	T8871	T8870	punct	", ",elegans
R5688	T8872	T8873	dep	which,interacts
R5689	T8873	T8870	relcl	interacts,elegans
R5690	T8874	T8873	prep	with,interacts
R5691	T8875	T8876	det	the,protein
R5692	T8876	T8874	pobj	protein,with
R5693	T8877	T8876	compound	ceTAC,protein
R5694	T8878	T8876	compound	binding,protein
R5695	T8879	T8876	appos	lin36,protein
R5696	T8880	T8881	punct	(,Fig.
R5697	T8881	T8873	parataxis	Fig.,interacts
R5698	T8882	T8881	nummod	6A,Fig.
R5699	T8883	T8881	punct	),Fig.
R5700	T8884	T8851	punct	.,is
R5701	T8886	T8887	nsubj	This,suggests
R5702	T8888	T8889	mark	that,evolved
R5703	T8889	T8887	ccomp	evolved,suggests
R5704	T8890	T8891	mark	while,require
R5705	T8891	T8889	advcl	require,evolved
R5706	T8892	T8893	compound	protostome,TACCs
R5707	T8893	T8891	nsubj	TACCs,require
R5708	T8894	T8891	aux	may,require
R5709	T8895	T8896	amod	additional,factors
R5710	T8896	T8891	dobj	factors,require
R5711	T8897	T8896	compound	protein,factors
R5712	T8898	T8899	aux	to,interact
R5713	T8899	T8891	advcl	interact,require
R5714	T8900	T8899	prep	with,interact
R5715	T8901	T8902	amod	such,components
R5716	T8902	T8900	pobj	components,with
R5717	T8903	T8889	punct	", ",evolved
R5718	T8904	T8905	det	the,TACCs
R5719	T8905	T8889	nsubj	TACCs,evolved
R5720	T8906	T8905	prep	in,TACCs
R5721	T8907	T8908	amod	higher,organisms
R5722	T8908	T8906	pobj	organisms,in
R5723	T8909	T8889	aux	may,evolved
R5724	T8910	T8889	aux	have,evolved
R5725	T8911	T8912	det	the,ability
R5726	T8912	T8889	dobj	ability,evolved
R5727	T8913	T8914	aux	to,interact
R5728	T8914	T8912	acl	interact,ability
R5729	T8915	T8914	advmod	directly,interact
R5730	T8916	T8914	prep	with,interact
R5731	T8917	T8916	pobj	some,with
R5732	T8918	T8917	prep	of,some
R5733	T8919	T8920	det	the,proteins
R5734	T8920	T8918	pobj	proteins,of
R5735	T8921	T8914	prep	in,interact
R5736	T8922	T8923	det	the,map
R5737	T8923	T8921	pobj	map,in
R5738	T8924	T8923	amod	predicted,map
R5739	T8925	T8923	compound	interaction,map
R5740	T8926	T8927	punct	(,Fig.
R5741	T8927	T8887	parataxis	Fig.,suggests
R5742	T8928	T8927	nummod	6E,Fig.
R5743	T8929	T8927	punct	),Fig.
R5744	T8930	T8887	punct	.,suggests
R5745	T8932	T8933	advmod	Indeed,appears
R5746	T8934	T8933	punct	", ",appears
R5747	T8935	T8933	nsubj	this,appears
R5748	T8936	T8937	aux	to,linked
R5749	T8937	T8933	xcomp	linked,appears
R5750	T8938	T8937	auxpass	be,linked
R5751	T8939	T8937	advmod	directly,linked
R5752	T8940	T8937	prep	to,linked
R5753	T8941	T8942	det	the,acquisition
R5754	T8942	T8940	pobj	acquisition,to
R5755	T8943	T8942	prep	of,acquisition
R5756	T8944	T8945	amod	new,domains
R5757	T8945	T8943	pobj	domains,of
R5758	T8946	T8942	cc	and,acquisition
R5759	T8947	T8942	conj	duplication,acquisition
R5760	T8948	T8947	prep	of,duplication
R5761	T8949	T8950	det	the,precursor
R5762	T8950	T8948	pobj	precursor,of
R5763	T8951	T8950	compound	chordate,precursor
R5764	T8952	T8950	compound	TACC,precursor
R5765	T8953	T8933	punct	.,appears
R5766	T8955	T8956	prep	In,was
R5767	T8957	T8955	pobj	fact,In
R5768	T8958	T8956	punct	", ",was
R5769	T8959	T8960	det	the,function
R5770	T8960	T8956	nsubj	function,was
R5771	T8961	T8960	amod	first,function
R5772	T8962	T8960	amod	identified,function
R5773	T8963	T8960	prep	of,function
R5774	T8964	T8965	det	a,protein
R5775	T8965	T8963	pobj	protein,of
R5776	T8966	T8965	compound	vertebrate,protein
R5777	T8967	T8965	compound	TACC,protein
R5778	T8968	T8956	prep	as,was
R5779	T8969	T8970	det	a,coactivator
R5780	T8970	T8968	pobj	coactivator,as
R5781	T8971	T8970	amod	transcriptional,coactivator
R5782	T8972	T8970	acl	acting,coactivator
R5783	T8973	T8972	prep	through,acting
R5784	T8974	T8975	det	a,interaction
R5785	T8975	T8973	pobj	interaction,through
R5786	T8976	T8975	amod	direct,interaction
R5787	T8977	T8975	prep	with,interaction
R5788	T8978	T8979	det	the,factor
R5789	T8979	T8977	pobj	factor,with
R5790	T8980	T8979	compound	ARNT,factor
R5791	T8981	T8979	compound	transcription,factor
R5792	T8982	T8983	punct	[,7
R5793	T8983	T8956	parataxis	7,was
R5794	T8984	T8983	punct	],7
R5795	T8985	T8956	punct	.,was
R5796	T8987	T8988	nsubj	It,is
R5797	T8989	T8988	advmod	also,is
R5798	T8990	T8988	acomp	intriguing,is
R5799	T8991	T8992	mark	that,interacts
R5800	T8992	T8988	ccomp	interacts,is
R5801	T8993	T8994	det	the,repeat
R5802	T8994	T8992	nsubj	repeat,interacts
R5803	T8995	T8996	npadvmod	deuterostome,specific
R5804	T8996	T8994	amod	specific,repeat
R5805	T8997	T8994	compound	SDP,repeat
R5806	T8998	T8992	prep	with,interacts
R5807	T8999	T8998	pobj	GAS41,with
R5808	T9000	T8999	punct	", ",GAS41
R5809	T9001	T9002	det	a,factor
R5810	T9002	T8999	appos	factor,GAS41
R5811	T9003	T9004	compound	component,accessory
R5812	T9004	T9002	compound	accessory,factor
R5813	T9005	T9004	punct	/,accessory
R5814	T9006	T9002	prep	of,factor
R5815	T9007	T9008	det	the,complex
R5816	T9008	T9006	pobj	complex,of
R5817	T9009	T9008	amod	human,complex
R5818	T9010	T9011	compound	SWI,SNF
R5819	T9011	T9008	compound	SNF,complex
R5820	T9012	T9011	punct	/,SNF
R5821	T9013	T9014	compound	chromatin,remodeling
R5822	T9014	T9008	compound	remodeling,complex
R5823	T9015	T9016	punct	[,15
R5824	T9016	T8988	parataxis	15,is
R5825	T9017	T9016	nummod	3,15
R5826	T9018	T9016	punct	",",15
R5827	T9019	T9016	punct	],15
R5828	T9020	T8988	punct	.,is
R5829	T9022	T9023	mark	Although,is
R5830	T9023	T9025	advcl	is,indicate
R5831	T9024	T9023	expl	there,is
R5832	T9026	T9027	det	a,homologue
R5833	T9027	T9023	attr	homologue,is
R5834	T9028	T9029	compound	D.,melanogaster
R5835	T9029	T9027	compound	melanogaster,homologue
R5836	T9030	T9027	prep	of,homologue
R5837	T9031	T9030	pobj	GAS41,of
R5838	T9032	T9027	punct	", ",homologue
R5839	T9033	T9027	appos	dmGAS41,homologue
R5840	T9034	T9025	punct	", ",indicate
R5841	T9035	T9036	det	the,database
R5842	T9036	T9025	nsubj	database,indicate
R5843	T9037	T9038	amod	large,scale
R5844	T9038	T9039	nmod	scale,interaction
R5845	T9039	T9036	compound	interaction,database
R5846	T9040	T9039	amod	proteomic,interaction
R5847	T9041	T9025	aux	does,indicate
R5848	T9042	T9025	neg	not,indicate
R5849	T9043	T9044	det	a,interaction
R5850	T9044	T9025	dobj	interaction,indicate
R5851	T9045	T9044	amod	direct,interaction
R5852	T9046	T9044	prep	of,interaction
R5853	T9047	T9046	pobj	dmGAS41,of
R5854	T9048	T9044	prep	with,interaction
R5855	T9049	T9048	pobj	DTACC,with
R5856	T9050	T9025	punct	.,indicate
R5857	T9052	T9053	nsubj	This,be
R5858	T9054	T9053	aux	may,be
R5859	T9055	T9053	prep	due,be
R5860	T9056	T9055	pcomp	to,due
R5861	T9057	T9058	det	the,lack
R5862	T9058	T9055	pobj	lack,due
R5863	T9059	T9058	prep	of,lack
R5864	T9060	T9061	det	the,region
R5865	T9061	T9059	pobj	region,of
R5866	T9062	T9063	compound	SDP,repeat
R5867	T9063	T9061	compound	repeat,region
R5868	T9064	T9058	prep	in,lack
R5869	T9065	T9066	det	the,protein
R5870	T9066	T9064	pobj	protein,in
R5871	T9067	T9066	compound	Drosophila,protein
R5872	T9068	T9066	compound	TACC,protein
R5873	T9069	T9053	punct	.,be
R5874	T9071	T9072	nsubj	This,suggests
R5875	T9073	T9072	advmod	further,suggests
R5876	T9074	T9075	mark	that,gained
R5877	T9075	T9072	advcl	gained,suggests
R5878	T9076	T9077	det	the,TACCs
R5879	T9077	T9075	nsubj	TACCs,gained
R5880	T9078	T9077	compound	vertebrate,TACCs
R5881	T9079	T9075	aux	have,gained
R5882	T9080	T9081	det	the,ability
R5883	T9081	T9075	dobj	ability,gained
R5884	T9082	T9081	amod	specific,ability
R5885	T9083	T9084	aux	to,interact
R5886	T9084	T9081	acl	interact,ability
R5887	T9085	T9084	amod	direct,interact
R5888	T9086	T9084	prep	with,interact
R5889	T9087	T9088	amod	transcriptional,complexes
R5890	T9088	T9086	pobj	complexes,with
R5891	T9089	T9088	amod	regulatory,complexes
R5892	T9090	T9075	punct	", ",gained
R5893	T9091	T9075	cc	and,gained
R5894	T9092	T9093	mark	that,required
R5895	T9093	T9075	conj	required,gained
R5896	T9094	T9095	amod	bridging,protein
R5897	T9095	T9093	nsubjpass	protein,required
R5898	T9096	T9095	punct	(,protein
R5899	T9097	T9095	nmod	s,protein
R5900	T9098	T9095	punct	),protein
R5901	T9099	T9093	auxpass	are,required
R5902	T9100	T9101	neg	no,longer
R5903	T9101	T9093	advmod	longer,required
R5904	T9102	T9072	punct	.,suggests
R5905	T9104	T9105	advmod	Thus,integrated
R5906	T9106	T9105	punct	", ",integrated
R5907	T9107	T9108	advmod	where,composed
R5908	T9108	T9105	advcl	composed,integrated
R5909	T9109	T9110	det	the,protein
R5910	T9110	T9108	nsubjpass	protein,composed
R5911	T9111	T9110	compound	ceTAC,protein
R5912	T9112	T9108	auxpass	is,composed
R5913	T9113	T9108	advmod	only,composed
R5914	T9114	T9108	prep	of,composed
R5915	T9115	T9116	det	the,domain
R5916	T9116	T9114	pobj	domain,of
R5917	T9117	T9116	compound	TACC,domain
R5918	T9118	T9105	punct	", ",integrated
R5919	T9119	T9120	det	the,members
R5920	T9120	T9105	nsubj	members,integrated
R5921	T9121	T9122	advmod	significantly,larger
R5922	T9122	T9120	amod	larger,members
R5923	T9123	T9120	compound	TACC,members
R5924	T9124	T9120	compound	family,members
R5925	T9125	T9120	prep	in,members
R5926	T9126	T9127	amod	higher,protostomes
R5927	T9127	T9125	pobj	protostomes,in
R5928	T9128	T9127	cc	and,protostomes
R5929	T9129	T9127	conj	deuterostomes,protostomes
R5930	T9130	T9105	aux	may,integrated
R5931	T9131	T9105	aux	have,integrated
R5932	T9132	T9133	nummod	one,functions
R5933	T9133	T9105	dobj	functions,integrated
R5934	T9134	T9132	cc	or,one
R5935	T9135	T9132	conj	more,one
R5936	T9136	T9133	prep	of,functions
R5937	T9137	T9138	det	the,protein
R5938	T9138	T9136	pobj	protein,of
R5939	T9139	T9138	amod	bridging,protein
R5940	T9140	T9138	punct	(,protein
R5941	T9141	T9138	prep	in,protein
R5942	T9142	T9143	det	this,case
R5943	T9143	T9141	pobj	case,in
R5944	T9144	T9138	appos	lin15A,protein
R5945	T9145	T9144	punct	", ",lin15A
R5946	T9146	T9144	conj	lin36,lin15A
R5947	T9147	T9146	cc	or,lin36
R5948	T9148	T9146	conj	lin37,lin36
R5949	T9149	T9105	punct	),integrated
R5950	T9150	T9105	punct	.,integrated
R5951	T9152	T9153	nsubj	This,explain
R5952	T9154	T9153	aux	may,explain
R5953	T9155	T9153	advmod	also,explain
R5954	T9156	T9157	det	the,absence
R5955	T9157	T9153	dobj	absence,explain
R5956	T9158	T9157	prep	of,absence
R5957	T9159	T9160	nmod	lin15A,homologues
R5958	T9160	T9158	pobj	homologues,of
R5959	T9161	T9159	punct	", ",lin15A
R5960	T9162	T9159	conj	lin36,lin15A
R5961	T9163	T9162	cc	and,lin36
R5962	T9164	T9162	conj	lin37,lin36
R5963	T9165	T9157	prep	in,absence
R5964	T9166	T9167	amod	higher,organisms
R5965	T9167	T9165	pobj	organisms,in
R5966	T9168	T9153	punct	", ",explain
R5967	T9169	T9170	mark	as,were
R5968	T9170	T9153	advcl	were,explain
R5969	T9171	T9170	nsubj	they,were
R5970	T9172	T9173	neg	no,longer
R5971	T9173	T9170	advmod	longer,were
R5972	T9174	T9170	prep	under,were
R5973	T9175	T9176	amod	selective,pressure
R5974	T9176	T9174	pobj	pressure,under
R5975	T9177	T9176	amod	evolutionary,pressure
R5976	T9178	T9179	aux	to,remain
R5977	T9179	T9176	acl	remain,pressure
R5978	T9180	T9179	prep	within,remain
R5979	T9181	T9182	det	the,complex
R5980	T9182	T9180	pobj	complex,within
R5981	T9183	T9170	punct	", ",were
R5982	T9184	T9170	cc	and,were
R5983	T9185	T9186	advmod	thus,lost
R5984	T9186	T9170	conj	lost,were
R5985	T9187	T9186	prep	in,lost
R5986	T9188	T9189	det	the,genome
R5987	T9189	T9187	pobj	genome,in
R5988	T9190	T9189	amod	evolving,genome
R5989	T9191	T9153	punct	.,explain
R5990	T9492	T9493	amod	Proposed,evolution
R5991	T9494	T9493	amod	functional,evolution
R5992	T9495	T9493	prep	of,evolution
R5993	T9496	T9497	det	the,family
R5994	T9497	T9495	pobj	family,of
R5995	T9498	T9497	compound	TACC,family
R5996	T9500	T9501	nsubj	Examination,provides
R5997	T9502	T9500	prep	of,Examination
R5998	T9503	T9504	det	the,evolution
R5999	T9504	T9502	pobj	evolution,of
R6000	T9505	T9504	prep	of,evolution
R6001	T9506	T9507	amod	ancient,families
R6002	T9507	T9505	pobj	families,of
R6003	T9508	T9507	compound	gene,families
R6004	T9509	T9510	det	an,insight
R6005	T9510	T9501	dobj	insight,provides
R6006	T9511	T9501	prep	into,provides
R6007	T9512	T9513	advmod	how,relates
R6008	T9513	T9511	pcomp	relates,into
R6009	T9514	T9515	compound	gene,structure
R6010	T9515	T9513	nsubj	structure,relates
R6011	T9516	T9513	prep	to,relates
R6012	T9517	T9516	pobj	function,to
R6013	T9518	T9501	punct	.,provides
R6014	T9520	T9521	nsubj	We,presented
R6015	T9522	T9521	aux	have,presented
R6016	T9523	T9521	advmod	above,presented
R6017	T9524	T9521	punct	", ",presented
R6018	T9525	T9526	det	a,examination
R6019	T9526	T9521	dobj	examination,presented
R6020	T9527	T9526	amod	detailed,examination
R6021	T9528	T9526	prep	of,examination
R6022	T9529	T9530	nummod	one,family
R6023	T9530	T9528	pobj	family,of
R6024	T9531	T9530	amod	such,family
R6025	T9532	T9530	compound	gene,family
R6026	T9533	T9521	punct	.,presented
R6027	T9535	T9536	det	The,data
R6028	T9536	T9537	nsubj	data,suggest
R6029	T9538	T9539	advmod	so,far
R6030	T9539	T9537	advmod	far,suggest
R6031	T9540	T9541	mark	that,has
R6032	T9541	T9537	ccomp	has,suggest
R6033	T9542	T9543	det	the,homologue
R6034	T9543	T9541	nsubj	homologue,has
R6035	T9544	T9543	amod	functional,homologue
R6036	T9545	T9543	compound	TACC,homologue
R6037	T9546	T9543	prep	in,homologue
R6038	T9547	T9546	pobj	yeast,in
R6039	T9548	T9543	punct	(,homologue
R6040	T9549	T9543	appos	spc72,homologue
R6041	T9550	T9543	punct	),homologue
R6042	T9551	T9552	det	a,role
R6043	T9552	T9541	dobj	role,has
R6044	T9553	T9552	amod	specific,role
R6045	T9554	T9552	prep	in,role
R6046	T9555	T9556	amod	centrosomal,mitotic
R6047	T9556	T9558	amod	mitotic,spindle
R6048	T9557	T9556	punct	/,mitotic
R6049	T9558	T9559	compound	spindle,dynamics
R6050	T9559	T9554	pobj	dynamics,in
R6051	T9560	T9561	punct	[,22
R6052	T9561	T9537	parataxis	22,suggest
R6053	T9562	T9561	nummod	21,22
R6054	T9563	T9561	punct	",",22
R6055	T9564	T9561	punct	],22
R6056	T9565	T9537	punct	.,suggest
R6057	T9567	T9568	det	This,function
R6058	T9568	T9571	nsubjpass	function,conserved
R6059	T9569	T9568	amod	ancient,function
R6060	T9570	T9568	compound	TACC,function
R6061	T9572	T9571	auxpass	is,conserved
R6062	T9573	T9571	prep	throughout,conserved
R6063	T9574	T9573	pobj	evolution,throughout
R6064	T9575	T9571	prep	in,conserved
R6065	T9576	T9577	preconj	both,protostomes
R6066	T9577	T9575	pobj	protostomes,in
R6067	T9578	T9577	cc	and,protostomes
R6068	T9579	T9577	conj	deuterostomes,protostomes
R6069	T9580	T9571	punct	.,conserved
R6070	T9582	T9583	prep	In,appear
R6071	T9584	T9582	pobj	addition,In
R6072	T9585	T9583	punct	", ",appear
R6073	T9586	T9587	det	the,proteins
R6074	T9587	T9583	nsubj	proteins,appear
R6075	T9588	T9587	compound	TACC,proteins
R6076	T9589	T9587	prep	of,proteins
R6077	T9590	T9591	amod	lower,organisms
R6078	T9591	T9589	pobj	organisms,of
R6079	T9592	T9593	aux	to,interact
R6080	T9593	T9583	xcomp	interact,appear
R6081	T9594	T9593	prep	with,interact
R6082	T9595	T9596	compound	bridging,proteins
R6083	T9596	T9594	pobj	proteins,with
R6084	T9597	T9598	dep	that,are
R6085	T9598	T9596	relcl	are,proteins
R6086	T9599	T9598	attr	components,are
R6087	T9600	T9599	prep	of,components
R6088	T9601	T9602	amod	several,complexes
R6089	T9602	T9600	pobj	complexes,of
R6090	T9603	T9602	amod	different,complexes
R6091	T9604	T9602	compound	protein,complexes
R6092	T9605	T9602	acl	involved,complexes
R6093	T9606	T9605	prep	in,involved
R6094	T9607	T9608	compound	DNA,damage
R6095	T9608	T9609	compound	damage,repair
R6096	T9609	T9606	pobj	repair,in
R6097	T9610	T9609	punct	", ",repair
R6098	T9611	T9612	compound	protein,translation
R6099	T9612	T9609	appos	translation,repair
R6100	T9613	T9609	punct	", ",repair
R6101	T9614	T9615	compound	RNA,processing
R6102	T9615	T9609	appos	processing,repair
R6103	T9616	T9615	cc	and,processing
R6104	T9617	T9615	conj	transcription,processing
R6105	T9618	T9583	punct	.,appear
R6106	T9620	T9621	advmod	However,acquired
R6107	T9622	T9621	punct	", ",acquired
R6108	T9623	T9621	prep	over,acquired
R6109	T9624	T9625	det	the,process
R6110	T9625	T9623	pobj	process,over
R6111	T9626	T9625	prep	of,process
R6112	T9627	T9628	amod	evolutionary,time
R6113	T9628	T9626	pobj	time,of
R6114	T9629	T9621	punct	", ",acquired
R6115	T9630	T9621	prep	with,acquired
R6116	T9631	T9632	det	the,acquisition
R6117	T9632	T9630	pobj	acquisition,with
R6118	T9633	T9632	prep	of,acquisition
R6119	T9634	T9635	amod	new,domains
R6120	T9635	T9633	pobj	domains,of
R6121	T9636	T9635	cc	and,domains
R6122	T9637	T9635	conj	duplication,domains
R6123	T9638	T9637	prep	of,duplication
R6124	T9639	T9640	det	the,precursor
R6125	T9640	T9638	pobj	precursor,of
R6126	T9641	T9640	compound	chordate,precursor
R6127	T9642	T9640	compound	TACC,precursor
R6128	T9643	T9621	punct	", ",acquired
R6129	T9644	T9645	det	the,proteins
R6130	T9645	T9621	nsubj	proteins,acquired
R6131	T9646	T9645	compound	chordate,proteins
R6132	T9647	T9645	compound	TACC,proteins
R6133	T9648	T9621	aux	have,acquired
R6134	T9649	T9650	det	the,ability
R6135	T9650	T9621	dobj	ability,acquired
R6136	T9651	T9652	aux	to,interact
R6137	T9652	T9650	acl	interact,ability
R6138	T9653	T9652	advmod	directly,interact
R6139	T9654	T9652	prep	with,interact
R6140	T9655	T9654	pobj	some,with
R6141	T9656	T9655	prep	of,some
R6142	T9657	T9658	det	the,components
R6143	T9658	T9656	pobj	components,of
R6144	T9659	T9658	amod	other,components
R6145	T9660	T9658	prep	of,components
R6146	T9661	T9662	det	these,complexes
R6147	T9662	T9660	pobj	complexes,of
R6148	T9663	T9655	punct	(,some
R6149	T9664	T9665	amod	such,as
R6150	T9665	T9655	prep	as,some
R6151	T9666	T9667	det	the,proteins
R6152	T9667	T9665	pobj	proteins,as
R6153	T9668	T9667	compound	LSm,proteins
R6154	T9669	T9667	punct	", ",proteins
R6155	T9670	T9671	amod	nuclear,receptors
R6156	T9671	T9667	conj	receptors,proteins
R6157	T9672	T9671	compound	hormone,receptors
R6158	T9673	T9671	punct	", ",receptors
R6159	T9674	T9671	conj	GAS41,receptors
R6160	T9675	T9674	punct	", ",GAS41
R6161	T9676	T9677	amod	accessory,proteins
R6162	T9677	T9674	conj	proteins,GAS41
R6163	T9678	T9677	cc	and,proteins
R6164	T9679	T9680	compound	transcription,factors
R6165	T9680	T9677	conj	factors,proteins
R6166	T9681	T9655	punct	),some
R6167	T9682	T9621	punct	", ",acquired
R6168	T9683	T9621	cc	and,acquired
R6169	T9684	T9685	advmod	thus,evolved
R6170	T9685	T9621	conj	evolved,acquired
R6171	T9686	T9687	amod	additional,functions
R6172	T9687	T9685	dobj	functions,evolved
R6173	T9688	T9685	prep	within,evolved
R6174	T9689	T9690	det	these,complexes
R6175	T9690	T9688	pobj	complexes,within
R6176	T9691	T9621	punct	.,acquired
R6177	T9693	T9694	advmod	Indeed,was
R6178	T9695	T9694	punct	", ",was
R6179	T9696	T9697	det	the,function
R6180	T9697	T9694	nsubj	function,was
R6181	T9698	T9697	amod	first,function
R6182	T9699	T9697	amod	assigned,function
R6183	T9700	T9697	prep	of,function
R6184	T9701	T9702	det	a,protein
R6185	T9702	T9700	pobj	protein,of
R6186	T9703	T9702	compound	vertebrate,protein
R6187	T9704	T9702	compound	TACC,protein
R6188	T9705	T9702	punct	", ",protein
R6189	T9706	T9707	compound	mouse,TACC3
R6190	T9707	T9702	appos	TACC3,protein
R6191	T9708	T9694	punct	", ",was
R6192	T9709	T9694	prep	as,was
R6193	T9710	T9711	det	a,coactivator
R6194	T9711	T9709	pobj	coactivator,as
R6195	T9712	T9711	amod	transcriptional,coactivator
R6196	T9713	T9711	prep	of,coactivator
R6197	T9714	T9715	det	the,response
R6198	T9715	T9713	pobj	response,of
R6199	T9716	T9717	npadvmod	ARNT,mediated
R6200	T9717	T9715	amod	mediated,response
R6201	T9718	T9715	amod	transcriptional,response
R66	T249	T247	pobj	interactions,between
R67	T250	T249	cc	and,interactions
R68	T251	T252	det	the,evolution
R69	T252	T249	conj	evolution,interactions
R70	T253	T252	prep	of,evolution
R71	T254	T255	det	these,proteins
R72	T255	T253	pobj	proteins,of
R85	T272	T265	advcl	determine,performed
R86	T273	T274	det	the,sequences
R91	T278	T274	prep	of,sequences
R92	T279	T280	det	the,TACCs
R93	T280	T278	pobj	TACCs,of
R94	T281	T280	prep	from,TACCs
R95	T282	T283	advmod	phylogenetically,diverse
R96	T283	T284	amod	diverse,organisms
R97	T284	T281	pobj	organisms,from
R98	T285	T265	punct	.,performed
R99	T287	T288	det	This,analysis
R100	T288	T289	nsubj	analysis,determined
R101	T290	T289	aux	has,determined
R102	T291	T292	det	the,relationship
R105	T294	T292	prep	of,relationship
R106	T295	T296	det	the,proteins
R109	T298	T292	prep	to,relationship
R110	T299	T300	amod	other,proteins
R114	T303	T292	punct	", ",relationship
R115	T304	T305	det	the,resolution
R116	T305	T292	conj	resolution,relationship
R117	T306	T305	prep	of,resolution
R118	T307	T308	det	the,placement
R119	T308	T306	pobj	placement,of
R120	T309	T308	prep	of,placement
R121	T310	T311	det	the,TACC4
R124	T313	T308	prep	as,placement
R125	T314	T315	det	the,orthologue
R126	T315	T313	pobj	orthologue,as
R127	T316	T315	prep	of,orthologue
R128	T317	T318	amod	human,TACC3
R129	T318	T316	pobj	TACC3,of
R130	T319	T305	punct	", ",resolution
R131	T320	T305	cc	and,resolution
R132	T321	T305	conj	RHAMM,resolution
R133	T322	T321	prep	as,RHAMM
R134	T323	T324	det	a,family
R137	T326	T324	prep	of,family
R138	T327	T328	amod	coiled,coil
R139	T328	T329	compound	coil,proteins
R140	T329	T326	pobj	proteins,of
R141	T330	T289	punct	.,determined
R142	T332	T333	nsubj	We,extended
R143	T334	T333	aux	have,extended
R144	T335	T333	advmod	also,extended
R145	T336	T337	det	the,analysis
R146	T337	T333	dobj	analysis,extended
R147	T338	T337	prep	of,analysis
R148	T339	T340	det	the,TACCs
R149	T340	T338	pobj	TACCs,of
R150	T341	T333	prep	to,extended
R151	T342	T343	det	the,databases
R154	T345	T343	prep	of,databases
R155	T346	T347	compound	C.,elegans
R156	T347	T345	pobj	elegans,of
R157	T348	T347	cc	and,elegans
R158	T349	T350	compound	D.,melanogaster
R159	T350	T347	conj	melanogaster,elegans
R160	T351	T352	aux	to,identify
R161	T352	T333	advcl	identify,extended
R162	T353	T354	advmod	potentially,novel
R163	T354	T355	amod	novel,interactions
R166	T357	T333	punct	.,extended
R167	T359	T360	det	The,validity
R276	T479	T477	pobj	proteins,of
R280	T483	T474	prep	from,evolved
R281	T484	T483	pcomp	performing,from
R282	T485	T486	nmod	assembly,functions
R286	T489	T484	prep	in,performing
R287	T490	T491	det	the,centrosome
R288	T491	T489	pobj	centrosome,in
R289	T492	T493	aux	to,include
R290	T493	T474	advcl	include,evolved
R291	T494	T495	det	a,role
R295	T498	T495	prep	in,role
R296	T499	T500	det	the,evolution
R299	T502	T500	prep	of,evolution
R300	T503	T504	compound	chromatin,remodeling
R301	T504	T502	pobj	remodeling,of
R302	T505	T504	punct	", ",remodeling
R303	T506	T507	amod	transcriptional,complexes
R307	T510	T500	prep	in,evolution
R308	T511	T512	det	the,cell
R309	T512	T510	pobj	cell,in
R310	T513	T472	punct	.,suggests
R2693	T4414	T4412	punct	),Fig.
R2694	T4415	T4398	punct	", ",located
R2695	T4416	T4417	advmod	further,suggesting
R2696	T4417	T4398	advcl	suggesting,located
R2697	T4418	T4419	mark	that,transposed
R2698	T4419	T4417	ccomp	transposed,suggesting
R2699	T4420	T4421	det	this,cluster
R8996	T13875	T13876	advmod	In,vitro
R8997	T13876	T13877	amod	vitro,interaction
R8998	T13878	T13877	prep	of,interaction
R1	T173	T174	compound	Structure,function
R4	T178	T177	prep	of,evolution
R5	T179	T180	det	the,genes
R11	T185	T177	acl	revealed,evolution
R12	T186	T185	agent	by,revealed
R13	T187	T186	pobj	analysis,by
R14	T188	T187	prep	of,analysis
R15	T189	T190	advmod	phylogenetically,diverse
R16	T190	T191	amod	diverse,organisms
R17	T191	T188	pobj	organisms,of
R18	T196	T197	nsubj	Examination,provide
R19	T198	T196	prep	of,Examination
R20	T199	T200	amod	ancient,families
R23	T202	T197	aux	can,provide
R24	T203	T204	det	an,insight
R25	T204	T197	dobj	insight,provide
R26	T205	T204	prep	into,insight
R27	T206	T207	advmod	how,relate
R35	T214	T207	prep	to,relate
R36	T215	T214	pobj	function,to
R37	T216	T197	punct	.,provide
R38	T218	T219	amod	Functional,homologs
R39	T219	T220	nsubj	homologs,are
R40	T221	T219	prep	of,homologs
R41	T222	T223	det	the,family
R53	T234	T220	acomp	present,are
R54	T235	T220	prep	in,are
R55	T236	T235	pobj	organisms,in
R56	T237	T236	prep	from,organisms
R57	T238	T237	pobj	yeast,from
R58	T239	T237	prep	to,from
R59	T240	T239	pobj	man,to
R60	T241	T220	punct	.,are
R61	T243	T244	advmod	However,have
R62	T245	T244	punct	", ",have
R63	T246	T244	nsubj	correlations,have
R64	T247	T246	prep	between,correlations
R65	T248	T249	amod	functional,interactions
R73	T256	T257	advmod	yet,determined
R77	T260	T244	punct	.,have
R78	T264	T265	nsubj	We,performed
R79	T266	T265	aux	have,performed
R80	T267	T268	det	an,analysis
R84	T271	T272	aux	to,determine
R168	T360	T361	nsubjpass	validity,confirmed
R169	T362	T360	prep	of,validity
R170	T363	T364	det	this,modeling
R171	T364	T362	pobj	modeling,of
R172	T365	T361	auxpass	was,confirmed
R173	T366	T361	advmod	independently,confirmed
R174	T367	T361	prep	by,confirmed
R175	T368	T369	det	the,demonstration
R176	T369	T367	pobj	demonstration,by
R177	T370	T369	prep	of,demonstration
R178	T371	T372	amod	direct,binding
R179	T372	T370	pobj	binding,of
R180	T373	T372	prep	of,binding
R181	T374	T375	amod	human,TACC2
R182	T375	T373	pobj	TACC2,of
R183	T376	T372	prep	to,binding
R184	T377	T378	det	the,receptor
R188	T381	T378	appos	RXRβ,receptor
R189	T382	T361	punct	.,confirmed
R190	T386	T387	det	The,data
R191	T387	T388	nsubj	data,suggest
R192	T389	T390	advmod	so,far
R193	T390	T387	advmod	far,data
R194	T391	T392	mark	that,played
R200	T397	T398	det	a,role
R201	T398	T392	dobj	role,played
R202	T399	T392	prep	in,played
R203	T400	T401	amod	centrosomal,mitotic
R208	T405	T388	punct	.,suggest
R209	T407	T408	compound	TACC,proteins
R210	T408	T409	nsubjpass	proteins,recruited
R211	T410	T409	auxpass	were,recruited
R212	T411	T409	advmod	then,recruited
R213	T412	T409	prep	to,recruited
R214	T413	T412	pobj	complexes,to
R215	T414	T413	acl	involved,complexes
R216	T415	T414	prep	in,involved
R217	T416	T417	compound	protein,translation
R218	T417	T415	pobj	translation,in
R219	T418	T417	punct	", ",translation
R220	T419	T420	compound	RNA,processing
R221	T420	T417	conj	processing,translation
R222	T421	T420	cc	and,processing
R223	T422	T420	conj	transcription,processing
R224	T423	T414	prep	by,involved
R225	T424	T423	pobj	interactions,by
R226	T425	T424	prep	with,interactions
R227	T426	T427	amod	specific,proteins
R230	T429	T409	punct	.,recruited
R231	T431	T432	advmod	However,acquired
R232	T433	T432	punct	", ",acquired
R233	T434	T432	prep	during,acquired
R234	T435	T434	pobj	evolution,during
R235	T436	T432	punct	", ",acquired
R236	T437	T438	det	the,proteins
R239	T440	T432	aux	have,acquired
R240	T441	T432	advmod	now,acquired
R241	T442	T443	det	the,ability
R242	T443	T432	dobj	ability,acquired
R243	T444	T445	aux	to,interact
R246	T447	T445	prep	with,interact
R247	T448	T447	pobj	components,with
R248	T449	T448	prep	of,components
R249	T450	T451	det	these,complexes
R250	T451	T449	pobj	complexes,of
R251	T452	T448	punct	(,components
R252	T453	T454	amod	such,as
R253	T454	T448	prep	as,components
R254	T455	T456	det	the,proteins
R257	T458	T456	punct	", ",proteins
R258	T459	T460	amod	nuclear,receptors
R261	T462	T460	punct	", ",receptors
R262	T463	T460	conj	GAS41,receptors
R263	T464	T463	punct	", ",GAS41
R264	T465	T463	cc	and,GAS41
R265	T466	T467	compound	transcription,factors
R266	T467	T463	conj	factors,GAS41
R267	T468	T448	punct	),components
R268	T469	T432	punct	.,acquired
R269	T471	T472	nsubj	This,suggests
R270	T473	T474	mark	that,evolved
R487	T884	T890	nsubjpass	gene,identified
R655	T1061	T1059	pcomp	associated,of
R4931	T7701	T7698	nsubjpass	protein,implicated
R4932	T7702	T7701	compound	ceTAC,protein
R4933	T7703	T7698	aux	has,implicated
R4934	T7704	T7698	advmod	also,implicated
R4935	T7705	T7698	advmod	recently,implicated
R4936	T7706	T7698	auxpass	been,implicated
R4937	T7707	T7698	prep	in,implicated
R4938	T7708	T7709	compound	DNA,repair
R4939	T7709	T7707	pobj	repair,in
R4940	T7710	T7698	prep	through,implicated
R4941	T7711	T7712	poss	its,interaction
R4942	T7712	T7710	pobj	interaction,through
R5000	T7773	T7774	prep	Because,predict
R5001	T7775	T7773	pcomp	of,Because
R5002	T7776	T7777	det	the,conservation
R5003	T7777	T7773	pobj	conservation,Because
R5004	T7778	T7777	amod	evolutionary,conservation
R5005	T7779	T7777	prep	of,conservation
R5006	T7780	T7781	det	the,domain
R5007	T7781	T7779	pobj	domain,of
R5008	T7782	T7781	compound	TACC,domain
R5009	T7783	T7774	punct	", ",predict
R5010	T7784	T7774	nsubj	we,predict
R5011	T7785	T7774	aux	would,predict
R5012	T7786	T7787	mark	that,observed
R5013	T7787	T7774	ccomp	observed,predict
R5014	T7788	T7787	nsubjpass	some,observed
R5015	T7789	T7788	prep	of,some
R5016	T7790	T7791	det	the,interactions
R5017	T7791	T7789	pobj	interactions,of
R5018	T7792	T7791	amod	functional,interactions
R5019	T7793	T7791	acl	seen,interactions
R5020	T7794	T7793	prep	in,seen
R5021	T7795	T7796	compound	C.,elegans
R5022	T7796	T7794	pobj	elegans,in
R5023	T7797	T7796	cc	and,elegans
R5024	T7798	T7799	compound	D.,melanogaster
R5025	T7799	T7796	conj	melanogaster,elegans
R5026	T7800	T7787	aux	would,observed
R5027	T7801	T7787	auxpass	be,observed
R5028	T7802	T7787	prep	in,observed
R5029	T7803	T7804	amod	higher,animals
R5030	T7804	T7802	pobj	animals,in
R5031	T7805	T7774	punct	.,predict
R1010	T1805	T1796	prep	in,found
R1011	T1806	T1807	amod	other,organisms
R1012	T1807	T1805	pobj	organisms,in
R1013	T1808	T1807	amod	non-metazoan,organisms
R1014	T1809	T1796	punct	.,found
R1015	T1818	T1819	nsubj	a,s
R1016	T1836	T1835	compound	ra,nch
R1017	T1837	T1835	prep	of,nch
R1018	T1838	T1837	pobj	life,of
R1019	T1839	T1833	punct	", ",identified
R1020	T1840	T1841	det	a,gene
R1021	T1841	T1833	nsubjpass	gene,identified
R1022	T1842	T1841	amod	single,gene
R1023	T1843	T1841	compound	TACC,gene
R1024	T1844	T1833	auxpass	was,identified
R2673	T4392	T4391	acomp	paralogous,are
R2674	T4393	T4392	prep	with,paralogous
R2675	T4394	T4393	pobj	4p16,with
R2676	T4395	T4381	punct	.,separate
R2677	T4397	T4398	advmod	Interestingly,located
R2678	T4399	T4398	punct	", ",located
R2679	T4400	T4401	det	these,clusters
R2680	T4401	T4398	nsubjpass	clusters,located
R2681	T4402	T4401	nummod	three,clusters
R2682	T4403	T4398	auxpass	are,located
R2683	T4404	T4398	prep	on,located
R2684	T4405	T4406	amod	different,chromosomes
R2685	T4406	T4404	pobj	chromosomes,on
R2686	T4407	T4398	prep	in,located
R2687	T4408	T4407	pobj	mouse,in
R2688	T4409	T4408	cc	and,mouse
R2689	T4410	T4408	conj	rat,mouse
R2690	T4411	T4412	punct	(,Fig.
R2691	T4412	T4398	parataxis	Fig.,located
R2692	T4413	T4412	nummod	2,Fig.
R2700	T4421	T4419	nsubjpass	cluster,transposed
R2701	T4422	T4421	prep	of,cluster
R2702	T4423	T4422	pobj	genes,of
R2703	T4424	T4419	auxpass	was,transposed
R2704	T4425	T4419	prep	into,transposed
R2705	T4426	T4427	det	this,region
R2706	T4427	T4425	pobj	region,into
R2707	T4428	T4419	prep	after,transposed
R2708	T4429	T4430	det	the,divergence
R2709	T4430	T4428	pobj	divergence,after
R2710	T4431	T4432	compound	primate,rodent
R2711	T4432	T4430	compound	rodent,divergence
R2712	T4433	T4432	punct	/,rodent
R2714	T4437	T4438	mark	Because,provide
R3363	T5125	T5123	prep	of,resolution
R3364	T5126	T5127	det	the,evolution
R3365	T5127	T5125	pobj	evolution,of
R3366	T5128	T5127	amod	initial,evolution
R3367	T5129	T5127	prep	of,evolution
R3368	T5130	T5131	det	these,segment
R3369	T5131	T5129	pobj	segment,of
R3370	T5132	T5131	amod	paralogous,segment
R3371	T5133	T5120	aux	will,await
R3372	T5134	T5135	det	the,sequencing
R3373	T5135	T5120	dobj	sequencing,await
R3374	T5136	T5135	prep	of,sequencing
R3375	T5137	T5138	det	the,genomes
R3376	T5138	T5136	pobj	genomes,of
R3377	T5139	T5138	nmod	amphioxus,genomes
R3378	T5140	T5139	cc	and,amphioxus
R3379	T5141	T5139	conj	lamprey,amphioxus
R3380	T5142	T5138	punct	", ",genomes
R3381	T5143	T5144	dep	which,have
R3382	T5144	T5138	relcl	have,genomes
R3383	T5145	T5144	advmod	only,have
R3384	T5146	T5147	nummod	one,gene
R3385	T5147	T5144	dobj	gene,have
R3386	T5148	T5147	compound	FGFR,gene
R3387	T5149	T5144	punct	", ",have
R3388	T5150	T5144	cc	and,have
R3389	T5151	T5152	advmod	therefore,contain
R3390	T5152	T5144	conj	contain,have
R3391	T5153	T5152	aux	should,contain
R3392	T5154	T5152	advmod	only,contain
R3393	T5155	T5156	nummod	one,copy
R3394	T5156	T5152	dobj	copy,contain
R3395	T5157	T5156	prep	of,copy
R3396	T5158	T5159	det	the,genes
R3397	T5159	T5157	pobj	genes,of

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T103	49-55	CHEBI_EXT:37527	denotes	acidic
T104	56-67	SO_EXT:0001080	denotes	coiled coil
T105	68-73	SO_EXT:0000704	denotes	genes
T106	123-132	NCBITaxon:1	denotes	organisms
T107	177-181	SO_EXT:0000704	denotes	gene
T108	240-244	SO_EXT:0000704	denotes	gene
T109	290-298	SO_EXT:0000853	denotes	homologs
T110	306-330	SO_EXT:biological_conservation_process_or_quality	denotes	evolutionarily conserved
T111	344-350	CHEBI_EXT:37527	denotes	acidic
T112	351-362	SO_EXT:0001080	denotes	coiled coil
T113	370-374	SO_EXT:0000704	denotes	gene
T114	397-406	NCBITaxon:1	denotes	organisms
T115	412-417	NCBITaxon_EXT:yeast	denotes	yeast
T116	421-424	NCBITaxon:9606	denotes	man
T117	507-515	CHEBI_PR_EXT:protein	denotes	proteins
T118	618-625	SO_EXT:0001026	denotes	genomic
T119	630-634	SO_EXT:cDNA	denotes	cDNA
T120	635-644	SO_EXT:biological_sequence	denotes	sequences
T121	688-697	NCBITaxon:1	denotes	organisms
T122	770-778	CHEBI_PR_EXT:protein	denotes	proteins
T123	788-799	SO_EXT:0001080	denotes	coiled coil
T124	800-808	CHEBI_PR_EXT:protein	denotes	proteins
T125	849-855	NCBITaxon:9986	denotes	rabbit
T126	869-879	SO_EXT:0000855	denotes	orthologue
T127	883-888	NCBITaxon:9606	denotes	human
T128	889-894	PR_EXT:000016008	denotes	TACC3
T129	900-905	PR_EXT:000001856	denotes	RHAMM
T130	930-941	SO_EXT:0001080	denotes	coiled coil
T131	942-950	CHEBI_PR_EXT:protein	denotes	proteins
T132	1032-1042	NCBITaxon:6239	denotes	C. elegans
T133	1047-1062	NCBITaxon:7227	denotes	D. melanogaster
T134	1201-1208	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T135	1212-1217	NCBITaxon:9606	denotes	human
T136	1218-1223	PR_EXT:000016007	denotes	TACC2
T137	1231-1238	GO:0005634	denotes	nuclear
T138	1239-1246	CHEBI_GO_EXT:hormone	denotes	hormone
T139	1247-1255	GO_EXT:0004872	denotes	receptor
T140	1256-1260	PR_EXT:000014373	denotes	RXRβ
T141	1322-1329	CHEBI_PR_EXT:protein	denotes	protein
T142	1347-1358	GO:0005813	denotes	centrosomal
T143	1359-1366	GO:0007067	denotes	mitotic
T144	1359-1374	GO:0072686	denotes	mitotic spindle
T145	1390-1398	CHEBI_PR_EXT:protein	denotes	proteins
T146	1409-1418	GO_EXT:biological_recruitment	denotes	recruited
T147	1422-1431	GO:0032991	denotes	complexes
T148	1444-1451	CHEBI_PR_EXT:protein	denotes	protein
T149	1452-1463	GO:0006412	denotes	translation
T150	1465-1468	CHEBI_SO_EXT:RNA	denotes	RNA
T151	1465-1479	GO:0006396	denotes	RNA processing
T152	1469-1479	SO_EXT:sequence_alteration_process	denotes	processing
T153	1484-1497	GO_EXT:transcription	denotes	transcription
T154	1528-1536	GO:0030674	denotes	bridging
T155	1537-1545	CHEBI_PR_EXT:protein	denotes	proteins
T156	1583-1591	CHEBI_PR_EXT:protein	denotes	proteins
T157	1668-1677	GO:0032991	denotes	complexes
T158	1695-1703	CHEBI_PR_EXT:protein	denotes	proteins
T159	1705-1712	GO:0005634	denotes	nuclear
T160	1713-1720	CHEBI_GO_EXT:hormone	denotes	hormone
T161	1721-1730	GO_EXT:0004872	denotes	receptors
T162	1732-1737	PR_EXT:000017527	denotes	GAS41
T163	1743-1756	GO_EXT:transcription	denotes	transcription
T164	1743-1764	GO_EXT:transcription_factor	denotes	transcription factors
T165	1811-1819	CHEBI_PR_EXT:protein	denotes	proteins
T166	1895-1905	GO:0005813	denotes	centrosome
T167	1969-1978	GO:0000785	denotes	chromatin
T168	1969-1989	GO:0006338	denotes	chromatin remodeling
T169	1991-2006	GO_EXT:transcription	denotes	transcriptional
T170	2015-2030	GO_EXT:transcription	denotes	transcriptional
T171	2031-2040	GO:0032991	denotes	complexes
T172	2048-2052	CL_GO_EXT:cell	denotes	cell
T625	2091-2100	NCBITaxon:1	denotes	organisms
T626	2144-2148	SO_EXT:0000704	denotes	gene
T627	2175-2186	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T628	2235-2240	SO_EXT:0000704	denotes	genes
T629	2287-2295	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T630	2299-2310	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T631	2315-2319	SO_EXT:0000147	denotes	exon
T632	2338-2342	SO_EXT:0000704	denotes	gene
T633	2353-2358	SO_EXT:0000704	denotes	genes
T634	2483-2489	SO_EXT:0001026	denotes	genome
T635	2513-2518	NCBITaxon:9606	denotes	human
T636	2520-2525	NCBITaxon:10088	denotes	mouse
T637	2527-2530	NCBITaxon:10114	denotes	rat
T638	2532-2541	NCBITaxon:7215	denotes	fruit fly
T639	2546-2555	NCBITaxon:6231	denotes	nematodes
T640	2628-2633	SO_EXT:0000704	denotes	genes
T641	2671-2679	NCBITaxon:1	denotes	organism
T642	2793-2798	SO_EXT:0000704	denotes	genes
T643	2803-2807	SO_EXT:0000704	denotes	gene
T644	2831-2835	SO_EXT:0000704	denotes	gene
T645	2854-2863	NCBITaxon:1	denotes	organisms
T646	2931-2938	SO_EXT:0001026	denotes	genomic
T647	3060-3064	SO_EXT:0000704	denotes	gene
T648	3079-3086	CHEBI_PR_EXT:protein	denotes	protein
T649	3120-3126	CHEBI_EXT:37527	denotes	acidic
T650	3127-3138	SO_EXT:0001080	denotes	coiled coil
T651	3139-3143	SO_EXT:0000704	denotes	gene
T652	3145-3150	PR_EXT:000016006	denotes	TACC1
T653	3196-3206	GO:0010467	denotes	expression
T654	3196-3210	SO_EXT:0001428	denotes	expression map
T655	3233-3239	_FRAGMENT	denotes	arm of
T656	3246-3256	SO_EXT:0000105	denotes	chromosome
T657	3240-3245	NCBITaxon:9606	denotes	human
T658	3246-3256	GO_SO_EXT:chromosome	denotes	chromosome
T659	3342-3352	_FRAGMENT	denotes	paralogous
T660	3365-3372	SO_EXT:0000854	denotes	regions
T661	3353-3372	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal regions
T662	3365-3375	_FRAGMENT	denotes	regions on
T663	3382-3393	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomes
T664	3376-3381	NCBITaxon:9606	denotes	human
T665	3382-3393	GO_SO_EXT:chromosome	denotes	chromosomes
T666	3445-3449	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T667	3450-3454	SO_EXT:0000704	denotes	gene
T668	3534-3538	SO_EXT:0000704	denotes	gene
T669	3546-3557	NCBITaxon:33317	denotes	protostomes
T670	3558-3579	NCBITaxon:6239	denotes	Caenorhabitis elegans
T671	3585-3608	NCBITaxon:7227	denotes	Drosophila melanogaster
T672	3658-3662	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T673	3672-3677	SO_EXT:0000704	denotes	genes
T674	3753-3764	NCBITaxon:7742	denotes	vertebrates
T675	3788-3800	SO_EXT:sequence_duplication_entity_or_process	denotes	duplications
T676	3818-3822	SO_EXT:0000704	denotes	gene
T677	3893-3897	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T678	3898-3903	SO_EXT:0000704	denotes	genes
T679	3907-3913	NCBITaxon:9606	denotes	humans
T680	3970-3980	NCBITaxon:7742	denotes	vertebrate
T681	3981-3987	SO_EXT:0001026	denotes	genome
T682	4024-4028	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T683	4046-4057	NCBITaxon:7742	denotes	vertebrates
T684	4105-4109	SO_EXT:0000704	denotes	gene
T685	4129-4134	PR_EXT:000001451	denotes	FGFR4
T686	4138-4148	NCBITaxon:7742	denotes	vertebrate
T687	4149-4156	SO_EXT:0001026	denotes	genomes
T688	4190-4195	SO_EXT:0000704	denotes	genes
T689	4206-4212	SO_EXT:sequence_cloning_process	denotes	cloned
T690	4216-4222	NCBITaxon:9606	denotes	humans
T691	4245-4250	NCBITaxon:10088	denotes	mouse
T692	4256-4270	NCBITaxon:8355	denotes	Xenopus laevis
T693	4276-4291	NCBITaxon:7227	denotes	D. melanogaster
T694	4301-4311	NCBITaxon:6239	denotes	C. elegans
T695	4378-4399	NCBITaxon:9986	denotes	Oryctolagus cuniculus
T696	4414-4419	NCBITaxon:9606	denotes	human
T697	4420-4425	PR_EXT:000001856	denotes	RHAMM
T698	4638-4647	NCBITaxon:1	denotes	organisms
T699	4649-4670	GO:0000380	denotes	alternatively spliced
T700	4649-4679	SO_EXT:alternative_splice_variant	denotes	alternatively spliced isoforms
T701	4750-4755	SO_EXT:0000704	denotes	genes
T702	4789-4800	SO_EXT:0001080	denotes	coiled coil
T1442	5236-5243	NCBITaxon:species	denotes	species
T1443	5283-5291	SO_EXT:biological_sequence	denotes	sequence
T1444	5304-5309	SO_EXT:0000704	denotes	genes
T1445	5422-5431	SO_EXT:biological_sequence	denotes	sequences
T1446	5443-5452	NCBITaxon:1	denotes	organisms
T1447	5495-5499	SO_EXT:cDNA	denotes	cDNA
T1448	5527-5536	SO_EXT:biological_sequence	denotes	sequences
T1449	5546-5556	NCBITaxon:7742	denotes	vertebrate
T1450	5557-5564	NCBITaxon:species	denotes	species
T1451	5570-5583	NCBITaxon:7586	denotes	echinodermate
T1452	5584-5613	NCBITaxon:7668	denotes	Strongylocentrotus purpuratus
T1453	5622-5632	NCBITaxon:33317	denotes	protostome
T1454	5633-5639	NCBITaxon:6960	denotes	insect
T1455	5640-5657	NCBITaxon:7165	denotes	Anopheles gambiae
T1456	5702-5714	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T1457	5727-5732	SO_EXT:0000704	denotes	genes
T1458	5736-5744	NCBITaxon:33208	denotes	metazoan
T1459	5799-5803	SO_EXT:cDNA	denotes	cDNA
T1460	5804-5810	SO_EXT:0001026	denotes	genome
T1461	5837-5846	NCBITaxon:1	denotes	organisms
T1462	5888-5893	SO_EXT:0000704	denotes	genes
T1463	5980-5988	SO_EXT:biological_sequence	denotes	sequence
T1464	5996-6006	NCBITaxon:33213	denotes	bilaterian
T1465	6007-6016	NCBITaxon:33208	denotes	metazoans
T1466	6026-6034	NCBITaxon:6073	denotes	Cnidaria
T1467	6038-6046	NCBITaxon:6040	denotes	Porifera
T1468	6070-6078	SO_EXT:biological_sequence	denotes	sequence
T1469	6101-6110	NCBITaxon:1	denotes	organisms
T1470	6138-6147	SO_EXT:biological_sequence	denotes	sequences
T1471	6168-6174	SO_EXT:0000417	denotes	domain
T1472	6207-6215	NCBITaxon:33208	denotes	metazoan
T1473	6216-6225	NCBITaxon:1	denotes	organisms
T1474	6738-6739	SO_EXT:0001080	denotes	c
T1475	6741-6742	CHEBI_PR_EXT:protein	denotes	r
T1476	6744-6746	CHEBI_PR_EXT:protein	denotes	te
T1477	6748-6750	NCBITaxon:7711	denotes	ra
T1478	6777-6781	SO_EXT:0000704	denotes	gene
T1479	6804-6810	SO_EXT:0001026	denotes	genome
T1480	6818-6829	NCBITaxon:7712	denotes	urochordate
T1481	6830-6848	NCBITaxon:7719	denotes	Ciona intestinalis
T1482	6874-6882	SO_EXT:biological_sequence	denotes	sequence
T1483	6907-6926	NCBITaxon:7729	denotes	Halocynthia rortezi
T1484	6927-6930	SO_EXT:0000345	denotes	EST
T1485	7003-7007	SO_EXT:0000704	denotes	gene
T1486	7027-7035	NCBITaxon:7711	denotes	chordate
T1487	7091-7099	NCBITaxon:7711	denotes	chordate
T1488	7100-7106	SO_EXT:0001026	denotes	genome
T1489	7195-7206	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1490	7214-7222	NCBITaxon:7711	denotes	chordate
T1491	7223-7229	SO_EXT:0001026	denotes	genome
T1492	7244-7255	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1493	7304-7309	SO_EXT:0000704	denotes	genes
T1494	7315-7325	SO_EXT:sequence_duplication_process	denotes	duplicated
T1495	7380-7385	SO_EXT:0000704	denotes	genes
T1496	7418-7428	NCBITaxon:7742	denotes	vertebrate
T1497	7429-7435	SO_EXT:0001026	denotes	genome
T1498	7459-7469	NCBITaxon:31031	denotes	pufferfish
T1499	7470-7487	NCBITaxon:31033	denotes	Takifugu rubripes
T1500	7500-7505	SO_EXT:0000704	denotes	genes
T1501	7527-7532	NCBITaxon:9606	denotes	human
T1502	7533-7538	PR_EXT:000016006	denotes	TACC1
T1503	7586-7593	SO_EXT:0001026	denotes	genomic
T1504	7594-7605	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1505	7613-7629	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal loci
T1506	7643-7648	SO_EXT:0000704	denotes	genes
T1507	7686-7690	SO_EXT:0000704	denotes	gene
T1508	7709-7714	PR_EXT:000016008	denotes	TACC3
T1509	7743-7748	SO_EXT:0000704	denotes	genes
T1510	7768-7779	NCBITaxon:31033	denotes	T. rubripes
T1511	7795-7800	SO_EXT:0000704	denotes	genes
T1512	7821-7832	NCBITaxon:31033	denotes	T. rubripes
T1513	7833-7844	SO_EXT:0000855	denotes	orthologues
T1514	7848-7853	NCBITaxon:9606	denotes	human
T1515	7854-7859	PR_EXT:000016007	denotes	TACC2
T1516	7864-7869	PR_EXT:000016008	denotes	TACC3
T1517	7894-7899	SO_EXT:0000704	denotes	genes
T1518	7951-7956	PR_EXT:000016006	denotes	TACC1
T1519	7995-8005	SO:0000857	denotes	homologous
T1520	8030-8037	SO_EXT:sequence_coding_function	denotes	encodes
T1521	8072-8079	CHEBI_PR_EXT:protein	denotes	protein
T1522	8094-8098	SO_EXT:0000704	denotes	gene
T1523	8102-8109	SO_EXT:sequence_coding_function	denotes	encoded
T1524	8116-8121	SO_EXT:0000147	denotes	exons
T1525	8144-8145	CHEBI_SO_EXT:base	denotes	b
T1526	8153-8161	NCBITaxon:31032	denotes	Takifugu
T1527	8162-8170	SO_EXT:0001248	denotes	Scaffold
T1528	8231-8239	SO_EXT:biological_sequence	denotes	sequence
T1529	8244-8248	SO_EXT:0000704	denotes	gene
T1530	8310-8315	SO_EXT:0000147	denotes	exons
T1531	8348-8354	SO_EXT:0000188	denotes	intron
T1532	8355-8359	SO_EXT:0000147	denotes	exon
T1533	8398-8402	SO_EXT:0000704	denotes	gene
T1534	8453-8463	NCBITaxon:31031	denotes	pufferfish
T1535	8543-8551	NCBITaxon:1	denotes	organism
T1536	8620-8624	CL_GO_EXT:cell	denotes	cell
T1537	8659-8675	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal loci
T1538	8715-8720	SO_EXT:0000704	denotes	genes
T1539	8752-8763	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1540	8771-8790	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T1541	8806-8813	NCBITaxon:32443	denotes	teleost
T1542	8814-8819	PR_EXT:000016006	denotes	TACC1
T1543	8860-8867	SO_EXT:0001026	denotes	genomic
T1544	8868-8879	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1545	8901-8908	NCBITaxon:32443	denotes	teleost
T1546	8946-8957	NCBITaxon:31033	denotes	T. rubripes
T1547	9022-9027	PR_EXT:000016008	denotes	TACC3
T1548	9073-9083	NCBITaxon:7742	denotes	vertebrate
T1549	9084-9091	SO_EXT:0001026	denotes	genomic
T1550	9092-9103	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T1551	9127-9138	NCBITaxon:7742	denotes	vertebrates
T1552	9168-9174	GO:0008380	denotes	splice
T1553	9168-9183	SO_EXT:alternative_splice_variant	denotes	splice variants
T1554	9187-9192	PR_EXT:000016006	denotes	TACC1
T1555	9197-9202	PR_EXT:000016007	denotes	TACC2
T1556	9206-9218	NCBITaxon:10090	denotes	Mus musculus
T1557	9228-9236	SO_EXT:sequence_assembly_entity_or_process	denotes	assembly
T1558	9268-9279	SO_EXT:0000855	denotes	orthologues
T1559	9283-9288	PR_EXT:000016006	denotes	TACC1
T1560	9296-9311	NCBITaxon:10116	denotes	Rattus norvegus
T1561	9337-9345	SO_EXT:biological_sequence	denotes	sequence
T1562	9359-9364	NCBITaxon:10088	denotes	mouse
T1563	9365-9375	GO_SO_EXT:chromosome	denotes	chromosome
T1564	9365-9377	GO:0000805	denotes	chromosome X
T1565	9384-9388	SO_EXT:0000704	denotes	gene
T1566	9415-9420	NCBITaxon:10088	denotes	mouse
T1567	9421-9426	PR_EXT:000016006	denotes	TACC1
T1568	9468-9473	NCBITaxon:10088	denotes	mouse
T1569	9477-9483	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T1570	9528-9534	SO_EXT:0000188	denotes	intron
T1571	9552-9562	GO:0010467	denotes	expression
T1572	9589-9594	NCBITaxon:10088	denotes	mouse
T1573	9595-9598	CHEBI_SO_EXT:RNA	denotes	RNA
T1574	9602-9604	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	rt
T1575	9657-9665	SO_EXT:biological_sequence	denotes	sequence
T1576	9671-9691	SO_EXT:0000043	denotes	processed pseudogene
T1577	9704-9709	PR_EXT:000016006	denotes	TACC1
T1578	9710-9721	SO_EXT:0000336	denotes	pseudogenes
T1579	9749-9750	CHEBI_SO_EXT:base	denotes	b
T1580	9758-9776	GO_SO_EXT:centromere_or_centromeric_region_or_centromeric_orientation	denotes	centromeric region
T1581	9770-9779	_FRAGMENT	denotes	region of
T1582	9786-9796	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosome
T1583	9780-9785	NCBITaxon:9606	denotes	human
T1584	9862-9864	SO_EXT:0000028	denotes	bp
T1585	9872-9877	PR_EXT:000016006	denotes	TACC1
T1586	9878-9900	SO_EXT:0000205	denotes	3' untranslated region
T1587	9883-9893	GO:0006412	denotes	translated
T1588	9905-9916	SO_EXT:0000336	denotes	pseudogenes
T1589	9934-9939	PR_EXT:000016007	denotes	TACC2
T1590	9943-9948	PR_EXT:000016008	denotes	TACC3
T1591	9972-9981	NCBITaxon:40674	denotes	mammalian
T1592	9982-9989	NCBITaxon:species	denotes	species
T2571	10012-10022	NCBITaxon:7742	denotes	vertebrate
T2572	10023-10028	PR_EXT:000016008	denotes	TACC3
T2573	10029-10040	SO_EXT:0000855	denotes	orthologues
T2574	10105-10110	PR_EXT:000016008	denotes	TACC3
T2575	10111-10122	SO_EXT:0000855	denotes	orthologues
T2576	10168-10176	SO_EXT:biological_sequence	denotes	sequence
T2577	10214-10218	SO_EXT:0000704	denotes	gene
T2578	10251-10269	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal region
T2579	10290-10294	SO_EXT:0000704	denotes	gene
T2580	10310-10320	SO_EXT:sequence_duplication_process	denotes	duplicated
T2581	10334-10344	NCBITaxon:7742	denotes	vertebrate
T2582	10381-10392	NCBITaxon:31033	denotes	T. rubripes
T2583	10394-10401	NCBITaxon:9989	denotes	rodents
T2584	10406-10412	NCBITaxon:9606	denotes	humans
T2585	10438-10448	NCBITaxon:7742	denotes	vertebrate
T2586	10449-10454	PR_EXT:000016008	denotes	TACC3
T2587	10505-10512	SO_EXT:0001026	denotes	genomic
T2588	10513-10524	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T2589	10564-10568	SO_EXT:0000704	denotes	gene
T2590	10632-10639	SO_EXT:sequence_cloning_process	denotes	cloning
T2591	10678-10699	NCBITaxon:9986	denotes	Oryctolagus cuniculus
T2592	10762-10763	CHEBI_SO_EXT:base	denotes	b
T2593	10764-10768	SO_EXT:cDNA	denotes	cDNA
T2594	10822-10827	PR_EXT:000016008	denotes	TACC3
T2595	10877-10881	SO_EXT:0000704	denotes	gene
T2596	10905-10906	CHEBI_SO_EXT:base	denotes	b
T2597	10907-10917	SO_EXT:0000673	denotes	transcript
T2598	10943-10949	SO_EXT:sequence_cloning_process	denotes	cloned
T2599	10950-10954	SO_EXT:cDNA	denotes	cDNA
T2600	11013-11021	SO_EXT:biological_sequence	denotes	sequence
T2601	11025-11030	NCBITaxon:9606	denotes	human
T2602	11035-11040	NCBITaxon:10088	denotes	mouse
T2603	11041-11046	PR_EXT:000016008	denotes	TACC3
T2604	11104-11110	NCBITaxon:9986	denotes	rabbit
T2605	11111-11116	PR_EXT:000016008	denotes	TACC3
T2606	11117-11121	SO_EXT:cDNA	denotes	cDNA
T2607	11162-11167	SO_EXT:sequence_cloning_process	denotes	clone
T2608	11181-11187	NCBITaxon:9986	denotes	rabbit
T2609	11188-11193	PR_EXT:000016008	denotes	TACC3
T2610	11194-11202	SO_EXT:biological_sequence	denotes	sequence
T2611	11237-11242	NCBITaxon:9606	denotes	human
T2612	11247-11252	NCBITaxon:10088	denotes	mouse
T2613	11253-11258	PR_EXT:000016008	denotes	TACC3
T2614	11294-11304	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T2615	11309-11319	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	C-terminal
T2616	11335-11340	NCBITaxon:9606	denotes	human
T2617	11345-11350	NCBITaxon:10088	denotes	mouse
T2618	11351-11356	PR_EXT:000016008	denotes	TACC3
T2619	11357-11365	CHEBI_PR_EXT:protein	denotes	proteins
T2620	11377-11386	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T2621	11431-11439	SO_EXT:biological_sequence	denotes	sequence
T2622	11463-11468	SO_EXT:0000704	denotes	genes
T2623	11484-11493	SO:0000993	denotes	consensus
T2624	11494-11509	CHEBI_SO_EXT:oligonucleotide	denotes	oligonucleotide
T2625	11510-11516	SO_EXT:0000112	denotes	primer
T2626	11611-11621	CHEBI_SO_EXT:methionine	denotes	methionine
T2627	11629-11634	PR_EXT:000016008	denotes	TACC3
T2628	11635-11640	SO_EXT:cDNA	denotes	cDNAs
T2629	11646-11654	NCBITaxon:9443	denotes	primates
T2630	11659-11666	NCBITaxon:9989	denotes	rodents
T2631	11679-11685	SO_EXT:0000112	denotes	primer
T2632	11731-11737	SO_EXT:0000112	denotes	primer
T2633	11804-11805	CHEBI_SO_EXT:base	denotes	b
T2634	11806-11817	SO_EXT:0000006	denotes	PCR product
T2635	11823-11829	NCBITaxon:9986	denotes	rabbit
T2636	11830-11835	UBERON:0000955	denotes	brain
T2637	11836-11840	SO_EXT:cDNA	denotes	cDNA
T2638	11844-11846	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	rt
T2639	11897-11906	SO:0000993	denotes	consensus
T2640	11907-11911	SO_EXT:cDNA	denotes	cDNA
T2641	11920-11922	SO_EXT:0000028	denotes	bp
T2642	11948-11958	SO_EXT:0000673	denotes	transcript
T2643	11972-11973	CHEBI_SO_EXT:base	denotes	b
T2644	11998-12006	SO_EXT:biological_sequence	denotes	sequence
T2645	12100-12108	SO_EXT:biological_sequence	denotes	sequence
T2646	12115-12133	GO:0000380	denotes	alternative splice
T2647	12115-12141	SO_EXT:alternative_splice_variant	denotes	alternative splice product
T2648	12166-12177	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T2649	12185-12190	PR_EXT:000016008	denotes	TACC3
T2650	12191-12195	SO_EXT:0000704	denotes	gene
T2651	12234-12240	NCBITaxon:9986	denotes	rabbit
T2652	12252-12262	SO_EXT:0000673	denotes	transcript
T2653	12275-12281	NCBITaxon:9986	denotes	rabbit
T2654	12282-12285	CHEBI_SO_EXT:RNA	denotes	RNA
T2655	12305-12325	SO_EXT:0002138	denotes	predicted transcript
T2656	12338-12343	PR_EXT:000016008	denotes	TACC3
T2657	12344-12352	SO_EXT:biological_sequence	denotes	sequence
T2658	12410-12421	CHEBI_SO_EXT:nucleotide	denotes	nucleotides
T2659	12457-12465	SO_EXT:biological_sequence	denotes	sequence
T2660	12510-12514	SO_EXT:cDNA	denotes	cDNA
T2661	12515-12524	SO_EXT:biological_sequence	denotes	sequences
T2662	12690-12696	NCBITaxon:9986	denotes	rabbit
T2663	12713-12719	NCBITaxon:9986	denotes	rabbit
T2664	12720-12725	PR_EXT:000016008	denotes	TACC3
T2665	12726-12734	SO_EXT:biological_sequence	denotes	sequence
T2666	12836-12841	PR_EXT:000016008	denotes	TACC3
T2667	12842-12853	SO_EXT:0000855	denotes	orthologues
T2668	12873-12887	NCBITaxon:8355	denotes	Xenopus laevis
T2669	12915-12920	PR_EXT:000016008	denotes	TACC3
T2670	12921-12930	SO_EXT:biological_sequence	denotes	sequences
T2671	12934-12949	NCBITaxon:10116	denotes	Rattus norvegus
T2672	12951-12964	NCBITaxon:9031	denotes	Gallus gallus
T2673	12966-12985	NCBITaxon:8364	denotes	Silurana tropicalis
T2674	12987-12998	NCBITaxon:7955	denotes	Danio rerio
T2675	13003-13014	NCBITaxon:31033	denotes	T. rubripes
T2676	13119-13127	SO_EXT:biological_sequence	denotes	sequence
T3361	13181-13186	PR_EXT:000001856	denotes	RHAMM
T3362	13187-13191	SO_EXT:0000704	denotes	gene
T3363	13216-13227	SO_EXT:0001080	denotes	coiled coil
T3364	13228-13232	SO_EXT:0000704	denotes	gene
T3365	13240-13245	NCBITaxon:9606	denotes	Human
T3366	13246-13251	PR_EXT:000001856	denotes	RHAMM
T3367	13384-13404	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal location
T3368	13416-13422	NCBITaxon:9606	denotes	humans
T3369	13446-13454	SO_EXT:biological_sequence	denotes	sequence
T3370	13473-13484	SO_EXT:0001080	denotes	coiled coil
T3371	13485-13491	SO_EXT:0000417	denotes	domain
T3372	13504-13510	SO_EXT:0000417	denotes	domain
T3373	13519-13530	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T3374	13522-13530	CL_GO_EXT:cell	denotes	cellular
T3375	13531-13543	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T3376	13551-13556	PR_EXT:000001856	denotes	RHAMM
T3377	13557-13564	CHEBI_PR_EXT:protein	denotes	protein
T3378	13572-13582	GO:0005813	denotes	centrosome
T3379	13596-13601	PR_EXT:000001856	denotes	RHAMM
T3380	13774-13784	NCBITaxon:7742	denotes	vertebrate
T3381	13785-13791	SO_EXT:0001026	denotes	genome
T3382	13822-13827	PR_EXT:000001856	denotes	RHAMM
T3383	13828-13839	SO_EXT:0000855	denotes	orthologues
T3384	13852-13857	SO_EXT:0000704	denotes	genes
T3385	13861-13870	NCBITaxon:33208	denotes	metazoans
T3386	13913-13924	SO_EXT:0001080	denotes	coiled coil
T3387	13981-13986	PR_EXT:000001856	denotes	RHAMM
T3388	13987-13991	SO_EXT:0000704	denotes	gene
T3389	13999-14012	NCBITaxon:33511	denotes	deuterostomes
T3390	14023-14027	SO_EXT:cDNA	denotes	cDNA
T3391	14035-14042	SO_EXT:0001026	denotes	genomic
T3392	14043-14051	SO_EXT:biological_sequence	denotes	sequence
T3393	14077-14092	NCBITaxon:7719	denotes	C. intestinalis
T3394	14097-14102	PR_EXT:000001856	denotes	RHAMM
T3395	14103-14107	SO_EXT:0000704	denotes	gene
T3396	14126-14133	NCBITaxon:6960	denotes	insects
T3397	14137-14146	NCBITaxon:6231	denotes	nematodes
T3398	14172-14177	PR_EXT:000001856	denotes	RHAMM
T3399	14183-14188	SO_EXT:0000704	denotes	genes
T3400	14208-14218	NCBITaxon:33317	denotes	protostome
T3401	14219-14231	NCBITaxon:33511	denotes	deuterostome
T3402	14268-14281	NCBITaxon:7586	denotes	echinodermata
T3403	14282-14293	NCBITaxon:7712	denotes	urochordate
T3404	14332-14340	SO_EXT:biological_sequence	denotes	sequence
T3405	14370-14381	SO_EXT:0001080	denotes	coiled coil
T3406	14382-14390	CHEBI_PR_EXT:protein	denotes	proteins
T3407	14419-14424	PR_EXT:000001856	denotes	RHAMM
T3408	14449-14455	SO_EXT:0000417	denotes	domain
T3409	14495-14503	CHEBI_PR_EXT:protein	denotes	proteins
T3410	14511-14522	SO_EXT:0001080	denotes	coiled coil
T3411	14589-14593	SO_EXT:0000704	denotes	gene
T3973	15207-15217	GO_SO_EXT:chromosome	denotes	chromosome
T3974	15236-15241	NCBITaxon:9606	denotes	human
T3975	15242-15252	GO_SO_EXT:chromosome	denotes	chromosome
T3976	15316-15328	NCBITaxon_EXT:invertebrate	denotes	invertebrate
T3977	15374-15378	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T3978	15384-15388	SO_EXT:0000704	denotes	gene
T3979	15435-15446	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T3980	15482-15492	_FRAGMENT	denotes	paralogous
T3981	15505-15513	SO_EXT:0000854	denotes	segments
T3982	15493-15513	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T3983	15609-15613	SO_EXT:0000704	denotes	gene
T3984	15617-15628	NCBITaxon:7742	denotes	vertebrates
T3985	15654-15672	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal region
T3986	15676-15681	PR_EXT:000001451	denotes	FGFR4
T3987	15739-15744	PR_EXT:000001856	denotes	RHAMM
T3988	15745-15749	SO_EXT:0000704	denotes	gene
T3989	15787-15792	NCBITaxon:9606	denotes	Human
T3990	15793-15798	PR_EXT:000001856	denotes	RHAMM
T3991	15807-15817	GO_SO_EXT:chromosome	denotes	chromosome
T3992	15846-15850	PR_EXT:000008212	denotes	GPX3
T3993	15855-15860	PR_EXT:000011245	denotes	NKX2E
T3994	15898-15903	SO_EXT:0000704	denotes	genes
T3995	15907-15912	NCBITaxon:9606	denotes	human
T3996	15913-15923	GO_SO_EXT:chromosome	denotes	chromosome
T3997	15935-15945	SO:0000859	denotes	paralogous
T3998	16018-16029	GO_SO_EXT:chromosome	denotes	chromosomes
T3999	16033-16038	NCBITaxon:10088	denotes	mouse
T4000	16043-16046	NCBITaxon:10114	denotes	rat
T4001	16097-16102	SO_EXT:0000704	denotes	genes
T4002	16107-16117	GO_SO_EXT:sequence_transposition_process	denotes	transposed
T4003	16145-16152	NCBITaxon:9443	denotes	primate
T4004	16153-16159	NCBITaxon:9989	denotes	rodent
T4006	16870-16874	SO_EXT:0000704	denotes	gene
T4007	16924-16928	SO_EXT:0000704	denotes	gene
T4008	16929-16939	GO:0065007	denotes	regulation
T4009	16991-17010	SO_EXT:0000854	denotes	paralogous segments
T4010	17028-17034	SO_EXT:0001026	denotes	genome
T4011	17042-17050	NCBITaxon:7712	denotes	tunicate
T4012	17051-17066	NCBITaxon:7719	denotes	C. intestinalis
T4013	17105-17115	NCBITaxon:7742	denotes	vertebrate
T4014	17116-17122	SO_EXT:0001026	denotes	genome
T4015	17142-17153	NCBITaxon:31033	denotes	T. rubripes
T4016	17209-17215	SO_EXT:0001026	denotes	genome
T4017	17219-17230	NCBITaxon:31033	denotes	T. rubripes
T4018	17257-17277	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T4019	17278-17288	SO:0000859	denotes	paralogous
T4020	17314-17325	NCBITaxon:7742	denotes	vertebrates
T4021	17354-17365	SO_EXT:0000855	denotes	orthologues
T4022	17369-17375	PR_EXT:000008258	denotes	GPRK2L
T4023	17380-17385	PR_EXT:000013947	denotes	RGS12
T4024	17399-17410	NCBITaxon:31033	denotes	T. rubripes
T4025	17411-17419	SO_EXT:0001248	denotes	scaffold
T4026	17462-17463	CHEBI_SO_EXT:base	denotes	b
T4027	17481-17486	NCBITaxon:9606	denotes	human
T4028	17497-17508	NCBITaxon:31033	denotes	T. rubripes
T4029	17509-17520	SO_EXT:0000855	denotes	orthologues
T4030	17524-17529	PR_EXT:000001450	denotes	FGFR3
T4031	17576-17577	CHEBI_SO_EXT:base	denotes	b
T4032	17578-17585	SO_EXT:0001026	denotes	genomic
T4033	17586-17594	SO_EXT:0001248	denotes	scaffold
T4034	17646-17651	NCBITaxon:9606	denotes	human
T4035	17652-17663	SO_EXT:0000855	denotes	orthologues
T4036	17673-17678	SO_EXT:0000704	denotes	genes
T4037	17708-17709	CHEBI_SO_EXT:base	denotes	b
T4038	17746-17751	PR_EXT:000016008	denotes	TACC3
T4039	17756-17761	PR_EXT:000007506	denotes	FGFRL
T4040	17785-17794	SO_EXT:0001248	denotes	scaffolds
T4041	17854-17858	SO_EXT:0000704	denotes	gene
T4042	17893-17898	PR_EXT:000008260	denotes	GPRK6
T4043	17902-17907	NCBITaxon:9606	denotes	human
T4044	17908-17918	GO_SO_EXT:chromosome	denotes	chromosome
T4045	17950-17960	NCBITaxon:31031	denotes	pufferfish
T4046	17971-17982	NCBITaxon:31033	denotes	T. rubripes
T4047	17983-17994	SO_EXT:0000855	denotes	orthologues
T4048	17998-18002	PR_EXT:000011441	denotes	NSD1
T4049	18004-18009	PR_EXT:000001451	denotes	FGFR4
T4050	18025-18029	SO_EXT:0000704	denotes	gene
T4051	18041-18049	SO_EXT:0001248	denotes	scaffold
T4052	18110-18114	SO_EXT:0000704	denotes	gene
T4053	18140-18144	SO_EXT:0000704	denotes	gene
T4054	18221-18230	SO_EXT:biological_sequence	denotes	sequences
T4055	18259-18264	PR_EXT:000016006	denotes	TACC1
T4056	18273-18278	SO_EXT:0000704	denotes	genes
T4057	18286-18296	NCBITaxon:31031	denotes	pufferfish
T4058	18330-18331	CHEBI_SO_EXT:base	denotes	b
T4059	18332-18340	SO_EXT:0001248	denotes	scaffold
T4060	18391-18402	SO_EXT:0000855	denotes	orthologues
T4061	18414-18419	SO_EXT:0000704	denotes	genes
T4062	18431-18436	NCBITaxon:9606	denotes	human
T4063	18437-18447	GO_SO_EXT:chromosome	denotes	chromosome
T4064	18468-18476	SO_EXT:0001248	denotes	scaffold
T4065	18509-18514	PR_EXT:000016006	denotes	TACC1
T4066	18515-18534	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T4067	18561-18572	NCBITaxon:7742	denotes	vertebrates
T4068	18606-18610	SO_EXT:0000704	denotes	gene
T4069	18634-18635	CHEBI_SO_EXT:base	denotes	b
T4070	18636-18644	SO_EXT:0001248	denotes	scaffold
T4071	18673-18681	SO_EXT:0001248	denotes	scaffold
T4072	18700-18711	NCBITaxon:31033	denotes	T. rubripes
T4073	18712-18723	SO_EXT:0000855	denotes	orthologues
T4074	18727-18731	PR_EXT:000010686	denotes	MSX1
T4075	18733-18738	PR_EXT:000015790	denotes	STX18
T4076	18756-18770	SO_EXT:0000996	denotes	predicted gene
T4077	18797-18806	SO_EXT:biological_sequence	denotes	sequences
T4078	18812-18820	SO:0000857	denotes	homology
T4079	18824-18828	PR_EXT:000009884	denotes	LOXL
T4080	18830-18833	PR_EXT:000007232	denotes	EVC
T4081	18872-18880	SO_EXT:0001248	denotes	scaffold
T4082	18893-18898	SO_EXT:0000704	denotes	genes
T4083	18912-18922	_FRAGMENT	denotes	regions of
T4084	18929-18939	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosome
T4085	18923-18928	NCBITaxon:9606	denotes	human
T4086	18980-18985	PR_EXT:000016008	denotes	TACC3
T4087	18990-18995	PR_EXT:000016007	denotes	TACC2
T4088	19055-19062	SO_EXT:0001026	denotes	genomic
T4089	19103-19114	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T4119	19894-19899	PR_EXT:000001856	denotes	RHAMM
T4120	19900-19905	SO_EXT:0000704	denotes	genes
T4121	19909-19924	NCBITaxon:7719	denotes	C. intestinalis
T4122	19975-19994	SO_EXT:0000854	denotes	paralogous segments
T4123	20012-20016	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T4124	20022-20027	SO_EXT:0000704	denotes	genes
T4125	20108-20121	GO_SO_EXT:sequence_rearrangement_entity_or_process	denotes	rearrangement
T4126	20125-20134	NCBITaxon:7712	denotes	tunicates
T4127	20179-20190	NCBITaxon:31033	denotes	T. rubripes
T4128	20191-20197	SO_EXT:0001026	denotes	genome
T4129	20270-20281	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T4130	20289-20308	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T4131	20328-20333	PR_EXT:000001450	denotes	FGFR3
T4132	20368-20372	SO_EXT:0000704	denotes	gene
T4133	20389-20393	SO_EXT:0000704	denotes	gene
T4134	20417-20427	NCBITaxon:7742	denotes	vertebrate
T4135	20470-20482	NCBITaxon:61463	denotes	Gnanthostome
T4136	20557-20575	SO_EXT:0000854	denotes	paralogous segment
T4137	20609-20618	NCBITaxon:7737	denotes	amphioxus
T4138	20623-20630	NCBITaxon:7745	denotes	lamprey
T4139	20631-20638	SO_EXT:0001026	denotes	genomes
T4140	20660-20664	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T4141	20665-20669	SO_EXT:0000704	denotes	gene
T4142	20709-20713	SO_EXT:sequence_copy_entity	denotes	copy
T4143	20741-20746	SO_EXT:0000704	denotes	genes
T4144	20755-20764	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T5361	21944-21951	SO_EXT:0001026	denotes	genomic
T5362	21985-21996	SO_EXT:genomic_DNA	denotes	genomic DNA
T5363	21993-21996	CHEBI_SO_EXT:DNA	denotes	DNA
T5364	21997-22006	SO_EXT:biological_sequence	denotes	sequences
T5365	22028-22039	SO:0000858	denotes	orthologous
T5366	22045-22050	SO_EXT:0000704	denotes	genes
T5367	22054-22059	NCBITaxon:9606	denotes	human
T5368	22061-22066	NCBITaxon:10088	denotes	mouse
T5369	22068-22071	NCBITaxon:10114	denotes	rat
T5370	22073-22083	NCBITaxon:31031	denotes	pufferfish
T5371	22085-22100	NCBITaxon:7719	denotes	C. intestinalis
T5372	22102-22117	NCBITaxon:7227	denotes	D. melanogaster
T5373	22122-22132	NCBITaxon:6239	denotes	C. elegans
T5374	22200-22207	SO_EXT:0001026	denotes	genomic
T5375	22231-22235	SO_EXT:0000704	denotes	gene
T5376	22256-22259	NCBITaxon:10114	denotes	rat
T5377	22264-22274	NCBITaxon:31031	denotes	pufferfish
T5378	22276-22281	SO_EXT:0000147	denotes	exons
T5379	22296-22304	SO_EXT:sequence_alteration_process	denotes	modified
T5380	22337-22347	GO:0006412	denotes	translated
T5381	22348-22356	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptides
T5382	22378-22383	NCBITaxon:10088	denotes	mouse
T5383	22388-22393	NCBITaxon:9606	denotes	human
T5384	22394-22402	CHEBI_PR_EXT:protein	denotes	proteins
T5385	22425-22433	SO_EXT:biological_sequence	denotes	sequence
T5386	22448-22459	NCBITaxon:31033	denotes	T. rubripes
T5387	22461-22468	SO_EXT:0001026	denotes	genomic
T5388	22469-22478	SO_EXT:biological_sequence	denotes	sequences
T5389	22495-22500	CHEBI:15377	denotes	water
T5390	22501-22511	NCBITaxon:31031	denotes	pufferfish
T5391	22513-22535	NCBITaxon:99883	denotes	Tetraodon nigroviridis
T5392	22590-22595	SO_EXT:0000147	denotes	exons
T5393	22631-22636	SO_EXT:0000704	denotes	genes
T5394	22641-22649	CHEBI_PR_EXT:protein	denotes	proteins
T5395	22682-22691	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T5396	22729-22735	SO_EXT:0000417	denotes	domain
T5397	22755-22771	CHEBI_SO_EXT:C_terminus_or_C_terminal_region	denotes	carboxy terminus
T5398	22779-22786	CHEBI_PR_EXT:protein	denotes	protein
T5399	22807-22817	NCBITaxon:6239	denotes	C. elegans
T5400	22822-22829	CHEBI_PR_EXT:protein	denotes	protein
T5401	22876-22883	CHEBI_PR_EXT:protein	denotes	protein
T5402	22891-22898	SO_EXT:sequence_coding_function	denotes	encoded
T5403	22919-22924	SO_EXT:0000147	denotes	exons
T5404	22932-22936	SO_EXT:0000704	denotes	gene
T5405	22952-22961	NCBITaxon:1	denotes	organisms
T5406	22963-22978	NCBITaxon:7227	denotes	D. melanogaster
T5407	22988-23001	NCBITaxon:33511	denotes	deuterostomes
T5408	23002-23017	NCBITaxon:7719	denotes	C. intestinalis
T5409	23021-23026	NCBITaxon:9606	denotes	human
T5410	23049-23056	SO_EXT:sequence_coding_function	denotes	encoded
T5411	23070-23075	SO_EXT:0000147	denotes	exons
T5412	23083-23087	SO_EXT:0000704	denotes	gene
T5413	23097-23112	NCBITaxon:7227	denotes	D. melanogaster
T5414	23127-23139	NCBITaxon:33511	denotes	deuterostome
T5415	23140-23145	SO_EXT:0000704	denotes	genes
T5416	23168-23174	SO_EXT:0000417	denotes	domain
T5417	23228-23236	SO:0000857	denotes	homology
T5418	23271-23275	SO_EXT:0000704	denotes	gene
T5419	23295-23299	SO_EXT:0000147	denotes	exon
T5420	23351-23362	SO_EXT:0000855	denotes	orthologues
T5421	23412-23417	PR_EXT:000016008	denotes	TACC3
T5422	23418-23423	SO_EXT:0000704	denotes	genes
T5423	23431-23442	NCBITaxon:7742	denotes	vertebrates
T5424	23459-23472	NCBITaxon:33511	denotes	deuterostomes
T5425	23479-23483	SO_EXT:0000147	denotes	exon
T5426	23501-23507	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T5427	23531-23537	NCBITaxon:39107	denotes	murine
T5428	23538-23545	PR_EXT:000016008	denotes	TACC3's
T5429	23549-23555	NCBITaxon:9989	denotes	rodent
T5430	23568-23578	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T5431	23579-23585	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T5432	23617-23624	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T5433	23632-23668	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T5434	23640-23660	GO:0006338	denotes	chromatin remodeling
T5435	23679-23684	PR_EXT:000017527	denotes	GAS41
T5436	23701-23711	NCBITaxon:7742	denotes	vertebrate
T5437	23717-23725	CHEBI_PR_EXT:protein	denotes	proteins
T5438	23731-23736	PR_EXT:000016008	denotes	TACC3
T5439	23737-23748	SO_EXT:0000855	denotes	orthologues
T5440	23791-23799	SO_EXT:biological_sequence	denotes	sequence
T5441	23826-23837	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T5442	23846-23849	NCBITaxon:10114	denotes	rat
T5443	23850-23855	PR_EXT:000016008	denotes	TACC3
T5444	23856-23863	CHEBI_PR_EXT:protein	denotes	protein
T5445	23872-23883	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T5446	23891-23902	NCBITaxon:7955	denotes	Danio rerio
T5447	23903-23910	CHEBI_PR_EXT:protein	denotes	protein
T5448	23968-23975	SO_EXT:0001026	denotes	genomic
T5449	23993-23998	PR_EXT:000016008	denotes	TACC3
T5450	23999-24010	SO_EXT:0000855	denotes	orthologues
T5451	24012-24017	PR_EXT:000016008	denotes	TACC3
T5452	24056-24065	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T5453	24066-24076	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminal
T5454	24098-24109	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T5455	24111-24118	SO_EXT:sequence_coding_function	denotes	encoded
T5456	24122-24127	SO_EXT:0000147	denotes	exons
T5457	24144-24154	NCBITaxon:7742	denotes	vertebrate
T5458	24155-24160	PR_EXT:000016008	denotes	TACC3
T5459	24161-24165	SO_EXT:0000704	denotes	gene
T5460	24171-24180	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T5461	24186-24192	SO_EXT:0000417	denotes	domain
T5462	24226-24231	SO_EXT:0000147	denotes	exons
T5463	24283-24295	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T5464	24313-24321	SO_EXT:biological_sequence	denotes	sequence
T5465	24352-24357	PR_EXT:000016008	denotes	TACC3
T5466	24358-24366	CHEBI_PR_EXT:protein	denotes	proteins
T5467	24370-24375	NCBITaxon:9606	denotes	human
T5468	24380-24385	NCBITaxon:10088	denotes	mouse
T5469	24469-24480	SO_EXT:0000855	denotes	orthologues
T5470	24547-24553	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T5471	24554-24560	SO_EXT:sequence_or_structure_motif	denotes	motifs
T5472	24565-24572	SO_EXT:sequence_coding_function	denotes	encoded
T5473	24580-24584	SO_EXT:0000147	denotes	exon
T5474	24588-24593	NCBITaxon:9606	denotes	human
T5475	24602-24612	NCBITaxon:31031	denotes	pufferfish
T5476	24636-24643	NCBITaxon:9989	denotes	rodents
T5477	24706-24716	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T5478	24717-24724	SO_EXT:sequence_repeat_unit_or_region	denotes	repeats
T5479	24756-24760	SO_EXT:0000147	denotes	exon
T5480	24768-24773	NCBITaxon:10088	denotes	mouse
T5481	24778-24781	NCBITaxon:10114	denotes	rat
T5482	24782-24787	PR_EXT:000016008	denotes	TACC3
T5483	24788-24793	SO_EXT:0000704	denotes	genes
T5484	24847-24852	NCBITaxon:10088	denotes	mouse
T5485	24853-24858	PR_EXT:000016008	denotes	TACC3
T5486	24859-24865	GO:0008380	denotes	splice
T5487	24859-24874	SO_EXT:alternative_splice_variant	denotes	splice variants
T5488	24910-24917	SO_EXT:sequence_repeat_unit_or_region	denotes	repeats
T5489	24937-24944	SO_EXT:sequence_repeat_unit_or_region	denotes	repeats
T5490	24969-24973	SO_EXT:0000147	denotes	exon
T5491	25014-25023	SO_EXT:biological_sequence	denotes	sequences
T5492	25049-25052	CHEBI_SO_EXT:DNA	denotes	DNA
T5493	25049-25064	GO_EXT:0034061	denotes	DNA polymerases
T5494	25077-25081	SO_EXT:cDNA	denotes	cDNA
T5495	25135-25141	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T5496	25142-25147	SO_EXT:sequence_or_structure_motif	denotes	motif
T5497	25161-25169	SO_EXT:biological_sequence	denotes	sequence
T5498	25266-25273	SO_EXT:sequence_repeat_unit_or_region	denotes	repeats
T5499	25297-25303	NCBITaxon:9986	denotes	rabbit
T5500	25304-25311	CHEBI_PR_EXT:protein	denotes	protein
T5501	25331-25338	CHEBI_PR_EXT:protein	denotes	protein
T5502	25366-25372	NCBITaxon:9989	denotes	rodent
T5503	25373-25378	PR_EXT:000016008	denotes	TACC3
T5504	25445-25454	NCBITaxon:8292	denotes	amphibian
T5505	25455-25462	NCBITaxon:8353	denotes	Xenopus
T5506	25463-25468	PR_EXT:000016008	denotes	TACC3
T6303	25483-25503	GO:0000380	denotes	Alternative splicing
T6304	25507-25517	NCBITaxon:7742	denotes	vertebrate
T6305	25523-25528	SO_EXT:0000704	denotes	genes
T6306	25537-25541	SO_EXT:0000147	denotes	exon
T6307	25596-25600	SO_EXT:0000704	denotes	gene
T6308	25654-25660	UBERON:0000479	denotes	tissue
T6309	25670-25690	GO:0000380	denotes	alternative splicing
T6310	25696-25700	SO_EXT:0000704	denotes	gene
T6311	25757-25761	SO_EXT:0000704	denotes	gene
T6312	25773-25787	_FRAGMENT	denotes	development of
T6313	25791-25799	GO:0044767	denotes	organism
T6314	25791-25799	NCBITaxon:1	denotes	organism
T6315	25813-25833	GO:0000380	denotes	alternative splicing
T6316	25837-25842	PR_EXT:000016008	denotes	TACC3
T6317	25890-25896	UBERON:0000479	denotes	tissue
T6318	25906-25914	GO:0008380	denotes	splicing
T6319	25934-25939	PR_EXT:000016006	denotes	TACC1
T6320	25944-25949	PR_EXT:000016007	denotes	TACC2
T6321	25950-25955	SO_EXT:0000704	denotes	genes
T6322	25972-25977	PR_EXT:000016007	denotes	TACC2
T6323	26003-26004	CHEBI_SO_EXT:base	denotes	b
T6324	26006-26010	SO_EXT:0000147	denotes	exon
T6325	26062-26068	GO:0008380	denotes	splice
T6326	26062-26077	SO_EXT:alternative_splice_variant	denotes	splice variants
T6327	26085-26095	NCBITaxon:7742	denotes	vertebrate
T6328	26096-26101	PR_EXT:000016007	denotes	TACC2
T6329	26102-26107	SO_EXT:0000704	denotes	genes
T6330	26117-26137	GO:0000380	denotes	alternative splicing
T6331	26146-26150	SO_EXT:0000147	denotes	exon
T6332	26206-26211	PR_EXT:000016007	denotes	TACC2
T6333	26212-26220	SO_EXT:0001060	denotes	isoforms
T6334	26289-26294	PR_EXT:000016007	denotes	TACC2
T6335	26333-26338	PR_EXT:000016006	denotes	TACC1
T6336	26391-26398	SO_EXT:0001060	denotes	isoform
T6337	26419-26439	GO:0000380	denotes	Alternative splicing
T6338	26468-26476	SO_EXT:0000167	denotes	promoter
T6339	26514-26519	NCBITaxon:9606	denotes	human
T6340	26520-26525	PR_EXT:000016006	denotes	TACC1
T6341	26526-26530	SO_EXT:0000704	denotes	gene
T6342	26603-26608	PR_EXT:000016006	denotes	TACC1
T6343	26609-26617	SO_EXT:0001060	denotes	isoforms
T6344	26635-26655	GO:0000380	denotes	alternative splicing
T6345	26659-26664	SO_EXT:0000147	denotes	exons
T6346	26705-26713	SO_EXT:0001060	denotes	isoforms
T6347	26746-26753	SO_EXT:sequence_deletion_process	denotes	deleted
T6348	26771-26779	SO_EXT:sequence_variant_entity	denotes	variants
T6349	26796-26803	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T6350	26796-26808	SO_EXT:0000409	denotes	binding site
T6351	26813-26817	PR_EXT:000009965	denotes	LSm7
T6352	26824-26832	SO_EXT:sequence_variant_entity	denotes	variants
T6353	26856-26863	GO:0005634	denotes	nuclear
T6354	26856-26884	SO_EXT:0001528	denotes	nuclear localization signals
T6355	26864-26876	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T6356	26889-26896	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T6357	26889-26901	SO_EXT:0000409	denotes	binding site
T6358	26906-26911	PR_EXT:000017527	denotes	GAS41
T6359	26921-26931	PR_EXT:000029784	denotes	PCTAIRE2BP
T6360	26938-26946	SO_EXT:0001060	denotes	isoforms
T6361	26969-26977	SO_EXT:0001060	denotes	isoforms
T6362	26989-26998	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T6363	27018-27027	GO:0005737	denotes	cytoplasm
T6364	27062-27070	SO_EXT:0001060	denotes	isoforms
T6365	27122-27130	GO:0000785	denotes	chomatin
T6366	27122-27141	GO:0006338	denotes	chomatin remodeling
T6367	27149-27152	CHEBI_SO_EXT:RNA	denotes	RNA
T6368	27149-27163	GO:0006396	denotes	RNA processing
T6369	27153-27163	SO_EXT:sequence_alteration_process	denotes	processing
T6370	27181-27188	GO:0005634	denotes	nucleus
T6371	27225-27230	PR_EXT:000016006	denotes	TACC1
T6372	27231-27239	SO_EXT:0001060	denotes	isoforms
T6373	27247-27251	CL_GO_EXT:cell	denotes	cell
T6374	27281-27289	CL_GO_EXT:cell	denotes	cellular
T6375	27281-27289	_FRAGMENT	denotes	cellular
T6376	27294-27304	GO:0044237	denotes	metabolism
T6377	27290-27293	CHEBI_SO_EXT:RNA	denotes	RNA
T6378	27290-27304	GO:0016070	denotes	RNA metabolism
T6379	27384-27392	SO_EXT:0001060	denotes	isoforms
T6380	27436-27450	UBERON:0001199	denotes	gastric mucosa
T7014	28703-28710	CHEBI_PR_EXT:protein	denotes	protein
T7015	28724-28731	CHEBI_PR_EXT:protein	denotes	protein
T7016	28736-28743	SO_EXT:0001026	denotes	genomic
T7017	28842-28849	CHEBI_PR_EXT:protein	denotes	protein
T7018	28902-28911	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T7019	28917-28923	SO_EXT:0000417	denotes	domain
T7020	28944-28951	CHEBI_PR_EXT:protein	denotes	protein
T7021	28952-28959	CHEBI_PR_EXT:protein	denotes	protein
T7022	28995-29002	GO:0007067	denotes	mitotic
T7023	28995-29010	GO:0072686	denotes	mitotic spindle
T7024	29015-29026	GO:0005813	denotes	centrosomal
T7025	29118-29127	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T7026	29154-29163	SO_EXT:0000853	denotes	homologue
T7027	29167-29172	NCBITaxon_EXT:yeast	denotes	yeast
T7028	29174-29180	PR_EXT:P39723	denotes	spc-72
T7029	29198-29203	NCBITaxon:9606	denotes	human
T7030	29209-29217	CHEBI_PR_EXT:protein	denotes	proteins
T7031	29260-29268	CHEBI_PR_EXT:protein	denotes	proteins
T7032	29309-29315	SO_EXT:0000417	denotes	domain
T7033	29326-29337	GO:0005874	denotes	microtubule
T7034	29338-29349	GO:0005813	denotes	centrosomal
T7035	29350-29358	CHEBI_PR_EXT:protein	denotes	proteins
T7036	29366-29370	PR_EXT:P46675	denotes	stu2
T7037	29371-29375	PR_EXT:Q9VEZ3	denotes	msps
T7038	29376-29382	PR_EXT:000005512	denotes	ch-TOG
T7039	29416-29430	PR_EXT:000035365	denotes	Aurora kinases
T7040	29423-29430	GO_EXT:0016301	denotes	kinases
T7041	29511-29516	PR_EXT:P39723	denotes	spc72
T7042	29529-29534	PR_EXT:000016008	denotes	TACC3
T7043	29535-29543	CHEBI_PR_EXT:protein	denotes	proteins
T7044	29551-29561	GO:0005813	denotes	centrosome
T7045	29619-29629	GO:0005813	denotes	centrosome
T7046	29634-29641	GO:0007067	denotes	mitotic
T7047	29634-29649	GO:0072686	denotes	mitotic spindle
T7048	29686-29695	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T7049	29758-29763	NCBITaxon:9606	denotes	human
T7050	29769-29777	CHEBI_PR_EXT:protein	denotes	proteins
T7051	29828-29842	PR_EXT:000035365	denotes	Aurora kinases
T7052	29835-29842	GO_EXT:0016301	denotes	kinases
T7053	29858-29863	PR_EXT:000016006	denotes	TACC1
T7054	29868-29873	PR_EXT:000016008	denotes	TACC3
T7055	29888-29903	PR_EXT:000004515	denotes	Aurora A kinase
T7056	29897-29903	GO_EXT:0016301	denotes	kinase
T7057	29913-29918	PR_EXT:000016007	denotes	TACC2
T7058	29934-29949	PR_EXT:000004518	denotes	Aurora C kinase
T7059	29943-29949	GO_EXT:0016301	denotes	kinase
T7060	30041-30049	NCBITaxon:7711	denotes	chordate
T7061	30083-30093	NCBITaxon:7742	denotes	vertebrate
T7062	30099-30104	SO_EXT:0000704	denotes	genes
T7063	30110-30122	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T7064	30130-30140	NCBITaxon:7742	denotes	vertebrate
T7065	30146-30154	CHEBI_PR_EXT:protein	denotes	proteins
T7066	30162-30172	GO:0051325	denotes	interphase
T7067	30173-30180	GO:0005634	denotes	nucleus
T7068	30271-30281	GO:0005813	denotes	centrosome
T7069	30286-30297	GO:0005874	denotes	microtubule
T7070	30286-30306	GO:0000226	denotes	microtubule dynamics
T7071	30358-30369	NCBITaxon:33317	denotes	protostomes
T7072	30374-30387	NCBITaxon:33511	denotes	deuterostomes
T7073	30446-30451	SO_EXT:0000704	denotes	genes
T7074	30472-30477	SO_EXT:0000147	denotes	exons
T7075	30538-30548	NCBITaxon:6239	denotes	C. elegans
T7107	31101-31107	PR_EXT:Q965W2	denotes	nhr-86
T7108	31178-31188	NCBITaxon:7215	denotes	Drosophila
T7109	31213-31221	CHEBI_PR_EXT:protein	denotes	proteins
T7110	31227-31230	CHEBI_SO_EXT:RNA	denotes	RNA
T7111	31231-31238	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T7112	31239-31246	CHEBI_PR_EXT:protein	denotes	protein
T7113	31304-31314	NCBITaxon:7215	denotes	Drosophila
T7114	31315-31351	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T7115	31323-31343	GO:0006338	denotes	chromatin remodeling
T7116	31356-31359	CHEBI_SO_EXT:DNA	denotes	DNA
T7117	31356-31373	GO:0006281	denotes	DNA damage repair
T7118	31410-31417	CHEBI_PR_EXT:protein	denotes	protein
T7119	31455-31458	CHEBI_SO_EXT:DNA	denotes	DNA
T7120	31455-31465	GO:0006281	denotes	DNA repair
T7121	31506-31516	NCBITaxon:6239	denotes	C. elegans
T7122	31517-31522	PR_EXT:000004642	denotes	BARD1
T7123	31523-31533	SO_EXT:0000855	denotes	orthologue
T7124	31603-31611	CHEBI_PR_EXT:protein	denotes	proteins
T7125	31623-31632	NCBITaxon:1	denotes	organisms
T7126	31755-31762	GO_EXT:0016301	denotes	kinases
T7127	31771-31775	PR_EXT:P46675	denotes	stu2
T7128	31776-31780	PR_EXT:Q9VEZ3	denotes	msps
T7129	31781-31787	PR_EXT:000005512	denotes	ch-TOG
T7130	32920-32945	SO_EXT:biological_conservation_process_or_quality	denotes	evolutionary conservation
T7131	32958-32964	SO_EXT:0000417	denotes	domain
T7132	33032-33042	NCBITaxon:6239	denotes	C. elegans
T7133	33047-33062	NCBITaxon:7227	denotes	D. melanogaster
T7134	33091-33098	NCBITaxon:33208	denotes	animals
T7135	33207-33217	NCBITaxon:7742	denotes	vertebrate
T7136	33267-33277	NCBITaxon:6239	denotes	C. elegans
T7137	33287-33295	CHEBI_PR_EXT:protein	denotes	proteins
T7138	33296-33302	PR_EXT:Q27365	denotes	lin15A
T7139	33304-33309	PR_EXT:P34427	denotes	lin36
T7140	33314-33319	PR_EXT:000009822	denotes	lin37
T7141	33352-33362	SO_EXT:0000853	denotes	homologues
T7142	33366-33377	NCBITaxon:7742	denotes	vertebrates
T7143	33381-33391	NCBITaxon:7215	denotes	Drosophila
T7144	33420-33424	CHEBI_EXT:zinc	denotes	zinc
T7145	33432-33438	SO_EXT:0000417	denotes	domain
T7146	33442-33447	PR_EXT:P34427	denotes	lin36
T7147	33470-33477	CHEBI_PR_EXT:protein	denotes	protein
T7148	33502-33515	GO_EXT:transcription	denotes	transcription
T7149	33530-33537	GO_EXT:0060090	denotes	adaptor
T7150	33569-33577	CHEBI_PR_EXT:protein	denotes	proteins
T7151	33605-33613	CHEBI_PR_EXT:protein	denotes	proteins
T7152	33635-33640	PR_EXT:000016057	denotes	TDP43
T7153	33644-33651	CHEBI_PR_EXT:protein	denotes	protein
T7154	33666-33681	GO_EXT:transcription	denotes	transcriptional
T7155	33682-33692	GO:0065007	denotes	regulation
T7156	33697-33705	GO:0008380	denotes	splicing
T7157	33746-33751	NCBITaxon:9606	denotes	human
T7158	33752-33761	SO_EXT:0000853	denotes	homologue
T7159	33820-33825	NCBITaxon:9606	denotes	human
T7160	33853-33862	CHEBI_SO_EXT:glutamine	denotes	glutamine
T7161	33868-33881	GO_EXT:transcription	denotes	transcription
T7162	33868-33889	GO_EXT:transcription_factor	denotes	transcription factors
T7163	33898-33902	PR_EXT:CREB	denotes	CREB
T7164	33911-33912	CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	G
T7165	33911-33916	SO_EXT:0001980	denotes	G-box
T7166	33917-33924	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T8188	34004-34014	NCBITaxon:7742	denotes	vertebrate
T8189	34020-34028	CHEBI_PR_EXT:protein	denotes	proteins
T8190	34058-34068	NCBITaxon:7742	denotes	vertebrate
T8191	34255-34265	NCBITaxon:7742	denotes	vertebrate
T8192	34286-34294	CHEBI_PR_EXT:protein	denotes	proteins
T8193	34345-34353	CHEBI_PR_EXT:protein	denotes	proteins
T8194	34368-34378	GO:0005813	denotes	centrosome
T8195	34379-34386	GO:0007067	denotes	mitotic
T8196	34379-34394	GO:0072686	denotes	mitotic spindle
T8197	34412-34420	CHEBI_PR_EXT:protein	denotes	proteins
T8198	34433-34437	SO_EXT:0000704	denotes	gene
T8199	34438-34448	GO:0065007	denotes	regulation
T8200	34473-34486	GO_EXT:transcription	denotes	transcription
T8201	34502-34505	CHEBI_SO_EXT:RNA	denotes	RNA
T8202	34502-34516	GO:0006396	denotes	RNA processing
T8203	34506-34516	SO_EXT:sequence_alteration_process	denotes	processing
T8204	34521-34532	GO:0006412	denotes	translation
T8205	34577-34585	CHEBI_PR_EXT:protein	denotes	proteins
T8206	34688-34695	CHEBI_PR_EXT:protein	denotes	protein
T8207	34688-34703	GO:0043234	denotes	protein complex
T8208	34780-34790	GO:0005813	denotes	centrosome
T8209	34811-34826	GO:0072686	denotes	mitotic spindle
T8210	34811-34835	GO:0090307	denotes	mitotic spindle assembly
T8211	34841-34846	NCBITaxon_EXT:yeast	denotes	yeast
T8212	34934-34944	NCBITaxon:7742	denotes	vertebrate
T8213	34945-34950	PR_EXT:000016008	denotes	TACC3
T8214	34951-34958	CHEBI_PR_EXT:protein	denotes	protein
T8215	35055-35062	GO:0007067	denotes	mitosis
T8216	35097-35112	PR_EXT:000004515	denotes	Aurora Kinase A
T8217	35104-35110	GO_EXT:0016301	denotes	Kinase
T8218	35154-35159	NCBITaxon:9606	denotes	human
T8219	35165-35172	CHEBI_PR_EXT:protein	denotes	protein
T8220	35173-35187	GO_PATO_EXT:phosphorylation_process_or_quality	denotes	phosphorylated
T8221	35196-35202	CHEBI_GO_SO_EXT:enzyme	denotes	enzyme
T8222	35249-35255	SO_EXT:0000417	denotes	domain
T8223	35263-35273	NCBITaxon:7742	denotes	vertebrate
T8224	35274-35285	SO_EXT:0000855	denotes	orthologues
T8225	35301-35306	PR_EXT:000016008	denotes	TACC3
T8226	35365-35372	NCBITaxon:species	denotes	species
T8227	35410-35419	NCBITaxon:8355	denotes	X. laevis
T8228	35432-35439	CHEBI_PR_EXT:protein	denotes	protein
T8229	35455-35462	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T8230	35455-35471	_FRAGMENT	denotes	binding site for
T8231	35482-35489	SO_EXT:0000410	denotes	protein
T8232	35476-35481	PR_EXT:000006990	denotes	eIF4E
T8233	35482-35489	CHEBI_PR_EXT:protein	denotes	protein
T8234	35530-35540	_FRAGMENT	denotes	control of
T8235	35561-35572	GO:0006417	denotes	translation
T8236	35541-35556	GO:0043631	denotes	polyadenylation
T8237	35580-35587	NCBITaxon:8353	denotes	Xenopus
T8238	35588-35594	CL:0000023	denotes	oocyte
T8239	35717-35727	NCBITaxon:7742	denotes	vertebrate
T8240	35728-35733	PR_EXT:000016008	denotes	TACC3
T8241	35734-35742	CHEBI_PR_EXT:protein	denotes	proteins
T8242	35761-35766	PR_EXT:000006990	denotes	eIF4E
T8243	35767-35771	PR_EXT:000005805	denotes	CPEB
T8244	35772-35779	GO:0032991	denotes	complex
T8245	35785-35790	NCBITaxon:9606	denotes	human
T8246	35798-35805	SO_EXT:0001060	denotes	isoform
T8247	35837-35842	PR_EXT:000006990	denotes	eIF4E
T8248	35843-35847	PR_EXT:000005805	denotes	CPEB
T8249	35848-35855	GO:0032991	denotes	complex
T8250	35871-35876	PR_EXT:000016006	denotes	TACC1
T8251	35877-35885	SO_EXT:0001060	denotes	isoforms
T8252	35977-35980	CHEBI_SO_EXT:RNA	denotes	RNA
T8253	35977-35989	GO:0008380	denotes	RNA splicing
T8254	35977-35980	_FRAGMENT	denotes	RNA
T8255	35994-36003	GO:0050658	denotes	transport
T8256	36079-36087	CHEBI_PR_EXT:protein	denotes	proteins
T8257	36114-36119	NCBITaxon_EXT:yeast	denotes	yeast
T8258	36160-36168	CHEBI_PR_EXT:protein	denotes	proteins
T8259	36174-36178	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T8260	36186-36191	NCBITaxon:9606	denotes	human
T8261	36197-36205	CHEBI_PR_EXT:protein	denotes	proteins
T8262	36248-36253	UBERON:0000955	denotes	brain
T8263	36318-36325	PR_EXT:000043452	denotes	histone
T8264	36318-36325	CHEBI:15358	denotes	histone
T8265	36318-36343	GO_EXT:0004402	denotes	histone acetyltransferase
T8266	36344-36351	PR_EXT:Q92830	denotes	hGCN5L2
T8267	36384-36391	SO_EXT:0001060	denotes	isoform
T8268	36395-36403	CHEBI:26537	denotes	retinoid
T8269	36395-36414	GO_EXT:0004886	denotes	retinoid-X receptor
T8270	36395-36416	PR_EXT:000014373	denotes	retinoid-X receptor β
T8271	36422-36429	CHEBI_PR_EXT:protein	denotes	protein
T8272	36459-36465	SO_EXT:0000417	denotes	domain
T8273	36469-36474	PR_EXT:000016007	denotes	TACC2
T8274	36538-36541	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T8275	36577-36581	PR_EXT:000014373	denotes	RXRβ
T8276	36616-36623	GO:0005634	denotes	nuclear
T8277	36624-36631	CHEBI_GO_EXT:hormone	denotes	hormone
T8278	36632-36640	GO_EXT:0004872	denotes	receptor
T8279	36642-36648	PR_EXT:Q965W2	denotes	nhr-86
T8280	36655-36665	NCBITaxon:6239	denotes	C. elegans
T8281	36698-36705	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T8282	36706-36713	CHEBI_PR_EXT:protein	denotes	protein
T8283	36714-36719	PR_EXT:P34427	denotes	lin36
T8284	36756-36766	NCBITaxon:33317	denotes	protostome
T8285	36796-36803	CHEBI_PR_EXT:protein	denotes	protein
T8286	36866-36875	NCBITaxon:1	denotes	organisms
T8287	36943-36951	CHEBI_PR_EXT:protein	denotes	proteins
T8288	37065-37072	SO_EXT:0000417	denotes	domains
T8289	37077-37088	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T8290	37096-37104	NCBITaxon:7711	denotes	chordate
T8291	37165-37175	NCBITaxon:7742	denotes	vertebrate
T8292	37181-37188	CHEBI_PR_EXT:protein	denotes	protein
T8293	37198-37213	GO_EXT:transcription	denotes	transcriptional
T8294	37198-37225	GO_EXT:0003713	denotes	transcriptional coactivator
T8295	37271-37275	PR_EXT:000004303	denotes	ARNT
T8296	37276-37289	GO_EXT:transcription	denotes	transcription
T8297	37276-37296	GO_EXT:transcription_factor	denotes	transcription factor
T8298	37333-37345	NCBITaxon:33511	denotes	deuterostome
T8299	37359-37365	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T8300	37381-37386	PR_EXT:000017527	denotes	GAS41
T8301	37424-37429	NCBITaxon:9606	denotes	human
T8302	37430-37466	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T8303	37438-37458	GO:0006338	denotes	chromatin remodeling
T8304	37495-37510	NCBITaxon:7227	denotes	D. melanogaster
T8305	37511-37520	SO_EXT:0000853	denotes	homologue
T8306	37524-37529	PR_EXT:000017527	denotes	GAS41
T8307	37688-37701	SO_EXT:0000657	denotes	repeat region
T8308	37709-37719	NCBITaxon:7215	denotes	Drosophila
T8309	37725-37732	CHEBI_PR_EXT:protein	denotes	protein
T8310	37765-37775	NCBITaxon:7742	denotes	vertebrate
T8311	37839-37854	GO_EXT:transcription	denotes	transcriptional
T8312	37855-37865	GO:0065007	denotes	regulatory
T8313	37866-37875	GO:0032991	denotes	complexes
T8314	37886-37894	GO:0030674	denotes	bridging
T8315	37895-37905	CHEBI_PR_EXT:protein	denotes	protein(s)
T8316	37952-37959	CHEBI_PR_EXT:protein	denotes	protein
T8317	37989-37995	SO_EXT:0000417	denotes	domain
T8318	38052-38063	NCBITaxon:33317	denotes	protostomes
T8319	38068-38081	NCBITaxon:33511	denotes	deuterostomes
T8320	38131-38139	GO:0030674	denotes	bridging
T8321	38140-38147	CHEBI_PR_EXT:protein	denotes	protein
T8322	38162-38168	PR_EXT:Q27365	denotes	lin15A
T8323	38170-38175	PR_EXT:P34427	denotes	lin36
T8324	38179-38184	PR_EXT:000009822	denotes	lin37
T8325	38224-38230	PR_EXT:Q27365	denotes	lin15A
T8326	38232-38237	PR_EXT:P34427	denotes	lin36
T8327	38242-38247	PR_EXT:000009822	denotes	lin37
T8328	38248-38258	SO_EXT:0000853	denotes	homologues
T8329	38269-38278	NCBITaxon:1	denotes	organisms
T8330	38362-38369	GO:0032991	denotes	complex
T8331	38401-38407	SO_EXT:0001026	denotes	genome
T9365	38886-38890	SO_EXT:0000704	denotes	gene
T9366	38929-38933	SO_EXT:0000704	denotes	gene
T9367	39025-39029	SO_EXT:0000704	denotes	gene
T9368	39087-39096	SO_EXT:0000853	denotes	homologue
T9369	39100-39105	NCBITaxon_EXT:yeast	denotes	yeast
T9370	39107-39112	PR_EXT:P39723	denotes	spc72
T9371	39137-39148	GO:0005813	denotes	centrosomal
T9372	39149-39156	GO:0007067	denotes	mitotic
T9373	39149-39164	GO:0072686	denotes	mitotic spindle
T9374	39213-39222	SO_EXT:biological_conservation_process_or_quality	denotes	conserved
T9375	39252-39263	NCBITaxon:33317	denotes	protostomes
T9376	39268-39281	NCBITaxon:33511	denotes	deuterostomes
T9377	39305-39313	CHEBI_PR_EXT:protein	denotes	proteins
T9378	39323-39332	NCBITaxon:1	denotes	organisms
T9379	39357-39365	GO:0030674	denotes	bridging
T9380	39366-39374	CHEBI_PR_EXT:protein	denotes	proteins
T9381	39416-39423	CHEBI_PR_EXT:protein	denotes	protein
T9382	39416-39433	GO:0043234	denotes	protein complexes
T9383	39446-39449	CHEBI_SO_EXT:DNA	denotes	DNA
T9384	39446-39463	GO:0006281	denotes	DNA damage repair
T9385	39465-39472	CHEBI_PR_EXT:protein	denotes	protein
T9386	39473-39484	GO:0006412	denotes	translation
T9387	39486-39489	CHEBI_SO_EXT:RNA	denotes	RNA
T9388	39486-39500	GO:0006396	denotes	RNA processing
T9389	39490-39500	SO_EXT:sequence_alteration_process	denotes	processing
T9390	39505-39518	GO_EXT:transcription	denotes	transcription
T9391	39596-39603	SO_EXT:0000417	denotes	domains
T9392	39608-39619	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T9393	39627-39635	NCBITaxon:7711	denotes	chordate
T9394	39656-39664	NCBITaxon:7711	denotes	chordate
T9395	39670-39678	CHEBI_PR_EXT:protein	denotes	proteins
T9396	39769-39778	GO:0032991	denotes	complexes
T9397	39796-39804	CHEBI_PR_EXT:protein	denotes	proteins
T9398	39806-39813	GO:0005634	denotes	nuclear
T9399	39814-39821	CHEBI_GO_EXT:hormone	denotes	hormone
T9400	39822-39831	GO_EXT:0004872	denotes	receptors
T9401	39833-39838	PR_EXT:000017527	denotes	GAS41
T9402	39850-39858	CHEBI_PR_EXT:protein	denotes	proteins
T9403	39863-39876	GO_EXT:transcription	denotes	transcription
T9404	39863-39884	GO_EXT:transcription_factor	denotes	transcription factors
T9405	39938-39947	GO:0032991	denotes	complexes
T9406	39990-40000	NCBITaxon:7742	denotes	vertebrate
T9407	40006-40013	CHEBI_PR_EXT:protein	denotes	protein
T9408	40015-40020	NCBITaxon:10088	denotes	mouse
T9409	40021-40026	PR_EXT:000016008	denotes	TACC3
T9410	40037-40052	GO_EXT:transcription	denotes	transcriptional
T9411	40037-40064	GO_EXT:0003713	denotes	transcriptional coactivator
T9412	40072-40076	PR_EXT:000004303	denotes	ARNT
T9413	40086-40101	GO_EXT:transcription	denotes	transcriptional
T9414	40102-40110	GO_EXT:reaction_or_response	denotes	response
T9415	40126-40151	CHEBI:33848	denotes	polyaromatic hydrocarbons
T9416	40157-40162	NCBITaxon:10088	denotes	Mouse
T9417	40163-40168	PR_EXT:000016008	denotes	TACC3
T9418	40213-40226	GO_EXT:transcription	denotes	transcription
T9419	40213-40233	GO_EXT:transcription_factor	denotes	transcription factor
T9420	40234-40239	PR_EXT:000002091	denotes	STAT5
T9421	40282-40287	PR_EXT:000016007	denotes	TACC2
T9422	40292-40297	PR_EXT:000016008	denotes	TACC3
T9423	40302-40306	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T9424	40310-40317	GO:0005634	denotes	nuclear
T9425	40318-40325	PR_EXT:000043452	denotes	histone
T9426	40318-40325	CHEBI:15358	denotes	histone
T9427	40318-40344	GO_EXT:0004402	denotes	histone acetyltransferases
T9428	40402-40410	CHEBI_PR_EXT:protein	denotes	proteins
T9429	40414-40429	GO_EXT:transcription	denotes	transcriptional
T9430	40434-40443	GO:0000785	denotes	chromatin
T9431	40434-40454	GO:0006338	denotes	chromatin remodeling
T9432	40490-40495	NCBITaxon:9606	denotes	human
T9433	40501-40509	CHEBI_PR_EXT:protein	denotes	proteins
T9434	40541-40548	PR_EXT:000043452	denotes	histone
T9435	40541-40548	CHEBI:15358	denotes	histone
T9436	40541-40566	GO_EXT:0004402	denotes	histone acetyltransferase
T9437	40567-40571	PR_EXT:000012332	denotes	pCAF
T9438	40586-40591	PR_EXT:000016006	denotes	TACC1
T9439	40592-40600	SO_EXT:0001060	denotes	isoforms
T9440	40601-40610	GO:0010467	denotes	expressed
T9441	40614-40619	NCBITaxon:9606	denotes	human
T9442	40620-40626	UBERON:0000310	denotes	breast
T9443	40634-40639	CL_GO_EXT:cell	denotes	cells
T9444	40666-40673	PR_EXT:000043452	denotes	histone
T9445	40666-40673	CHEBI:15358	denotes	histone
T9446	40666-40683	GO_EXT:0004402	denotes	histone acetylase
T9447	40747-40751	SO_EXT:0000147	denotes	Exon
T9448	40765-40770	PR_EXT:000016006	denotes	TACC1
T9449	40771-40779	SO_EXT:sequence_variant_entity	denotes	variants
T9450	40783-40786	CHEBI_SO_EXT:RNA	denotes	RNA
T9451	40783-40797	GO:0006396	denotes	RNA processing
T9452	40787-40797	SO_EXT:sequence_alteration_process	denotes	processing
T9453	40824-40829	PR_EXT:000009965	denotes	LSm-7
T9454	40834-40837	PR_EXT:000015348	denotes	SmG
T9455	40850-40870	GO:0000380	denotes	alternative splicing
T9456	40878-40883	PR_EXT:000016006	denotes	TACC1
T9457	40884-40888	SO_EXT:0000704	denotes	gene
T9458	40915-40920	PR_EXT:000016006	denotes	TACC1
T9459	40938-40946	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T9460	40959-40964	SO_EXT:0000147	denotes	exons
T9461	40986-40993	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T9462	40994-41001	SO_EXT:0000417	denotes	domains
T9463	41007-41013	SO_EXT:sequence_alteration_process	denotes	change
T9464	41028-41035	CHEBI_PR_EXT:protein	denotes	protein
T9465	41028-41045	GO:0043234	denotes	protein complexes
T9466	41102-41111	GO_EXT:biological_direction_or_guidance	denotes	directing
T9467	41116-41122	GO:0008380	denotes	splice
T9468	41116-41131	SO_EXT:alternative_splice_variant	denotes	splice variants
T9469	41145-41156	GO_UBERON_EXT:cellular_component_or_cell_part	denotes	subcellular
T9470	41148-41156	CL_GO_EXT:cell	denotes	cellular
T9471	41180-41191	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T9472	41199-41204	PR_EXT:000016006	denotes	TACC1
T9473	41205-41210	PR_EXT:000016007	denotes	TACC2
T9474	41329-41334	PR_EXT:000016007	denotes	TACC2
T9475	41335-41342	CHEBI_PR_EXT:protein	denotes	protein
T9476	41366-41371	PR_EXT:000016008	denotes	TACC3
T9477	41389-41394	PR_EXT:000017527	denotes	GAS41
T9478	41396-41400	PR_EXT:000015262	denotes	INI1
T9479	41402-41409	PR_EXT:000043452	denotes	histone
T9480	41402-41409	CHEBI:15358	denotes	histone
T9481	41402-41428	GO_EXT:0004402	denotes	histone acetyltransferases
T9482	41433-41446	GO_EXT:transcription	denotes	transcription
T9483	41433-41454	GO_EXT:transcription_factor	denotes	transcription factors
T9484	41470-41474	PR_EXT:000014373	denotes	RXRβ
T9485	41506-41512	UBERON:0000479	denotes	tissue
T9486	41522-41530	GO:0008380	denotes	splicing
T9487	41541-41542	CHEBI_SO_EXT:base	denotes	b
T9488	41543-41547	SO_EXT:0000147	denotes	exon
T9489	41562-41569	SO_EXT:0001060	denotes	isoform
T9490	41594-41601	CHEBI_PR_EXT:protein	denotes	protein
T9491	41627-41633	UBERON:0000479	denotes	tissue
T10055	41701-41709	SO_EXT:sequence_assembly_entity_or_process	denotes	assembly
T10056	41745-41750	SO_EXT:cDNA	denotes	cDNAs
T10057	41755-41760	SO_EXT:0000704	denotes	genes
T10058	41775-41786	SO:0000858	denotes	orthologous
T10059	41787-41796	SO_EXT:biological_sequence	denotes	sequences
T10060	41807-41812	PR_EXT:000001856	denotes	RHAMM
T10061	41931-41938	SO_EXT:0001026	denotes	genomic
T10062	41943-41947	SO_EXT:cDNA	denotes	cDNA
T10063	41963-41980	NCBITaxon:31033	denotes	Takifugu rubripes
T10064	41982-41986	SO_EXT:0000704	denotes	gene
T10065	42079-42082	CHEBI_SO_EXT:DNA	denotes	DNA
T10066	42083-42092	SO_EXT:biological_sequence	denotes	sequences
T10067	42106-42122	SO_EXT:0000853	denotes	homology regions
T10068	42182-42187	SO_EXT:0000147	denotes	exons
T10069	42204-42209	SO_EXT:0000147	denotes	exons
T10070	42224-42232	SO_EXT:sequence_alteration_process	denotes	modified
T10071	42265-42275	GO:0006412	denotes	translated
T10072	42276-42284	CHEBI_SO_EXT:peptide_or_peptide_region	denotes	peptides
T10073	42306-42311	NCBITaxon:10088	denotes	mouse
T10074	42316-42321	NCBITaxon:9606	denotes	human
T10075	42322-42330	CHEBI_PR_EXT:protein	denotes	proteins
T10076	42353-42361	SO_EXT:biological_sequence	denotes	sequence
T10077	42374-42381	SO_EXT:0001026	denotes	genomic
T10078	42382-42391	SO_EXT:biological_sequence	denotes	sequences
T10079	42408-42413	CHEBI:15377	denotes	water
T10080	42414-42424	NCBITaxon:31031	denotes	pufferfish
T10081	42426-42448	NCBITaxon:99883	denotes	Tetraodon nigroviridis
T10082	42503-42508	SO_EXT:0000147	denotes	exons
T10083	42558-42568	NCBITaxon:7742	denotes	vertebrate
T10084	42569-42574	PR_EXT:000016008	denotes	TACC3
T10085	42575-42580	SO_EXT:cDNA	denotes	cDNAs
T10086	42630-42647	NCBITaxon:31033	denotes	Takifugu rubripes
T10087	42648-42653	PR_EXT:000016008	denotes	TACC3
T10088	42667-42672	SO_EXT:cDNA	denotes	cDNAs
T10089	42694-42705	NCBITaxon:7955	denotes	Danio rerio
T10090	42706-42711	PR_EXT:000016008	denotes	TACC3
T10091	42719-42725	SO_EXT:sequence_cloned_entity	denotes	clones
T10092	42820-42830	_FRAGMENT	denotes	paralogous
T10093	42843-42851	SO_EXT:0000854	denotes	segments
T10094	42831-42851	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T10095	42856-42864	SO_EXT:0001248	denotes	scaffold
T10096	42944-42949	NCBITaxon:9606	denotes	Human
T10097	42950-42956	SO_EXT:0001026	denotes	Genome
T10382	42989-42996	SO_EXT:sequence_cloning_process	denotes	Cloning
T10383	43000-43010	NCBITaxon:7742	denotes	vertebrate
T10384	43016-43021	SO_EXT:cDNA	denotes	cDNAs
T10385	43026-43032	NCBITaxon:9986	denotes	rabbit
T10386	43033-43038	PR_EXT:000016008	denotes	TACC3
T10387	43043-43049	SO_EXT:sequence_cloning_process	denotes	cloned
T10388	43053-43055	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	rt
T10389	43087-43093	SO_EXT:0000112	denotes	primer
T10390	43148-43157	SO:0000993	denotes	consensus
T10391	43158-43164	SO_EXT:0000112	denotes	primer
T10392	43214-43224	NCBITaxon:7742	denotes	vertebrate
T10393	43225-43230	PR_EXT:000016008	denotes	TACC3
T10394	43241-43251	CHEBI_SO_EXT:methionine	denotes	methionine
T10395	43291-43298	SO_EXT:sequence_cloning_process	denotes	cloning
T10396	43303-43308	NCBITaxon:10088	denotes	mouse
T10397	43316-43320	SO_EXT:cDNA	denotes	cDNA
T10398	43326-43333	SO_EXT:0000112	denotes	primers
T10399	43359-43366	SO_EXT:0001026	denotes	genomic
T10400	43367-43375	SO_EXT:biological_sequence	denotes	sequence
T10401	43394-43402	SO_EXT:biological_sequence	denotes	sequence
T10402	43416-43426	SO_EXT:0000317	denotes	cDNA clone
T10403	43689-43694	PR_EXT:000016006	denotes	TACC1
T10404	43695-43701	GO:0000380	denotes	splice
T10405	43695-43710	SO_EXT:alternative_splice_variant	denotes	splice variants
T10406	43716-43731	SO_EXT:0000121	denotes	forward primers
T10407	43753-43757	SO_EXT:0000147	denotes	exon
T10408	43794-43798	SO_EXT:0000147	denotes	Exon
T10409	43838-43842	SO_EXT:0000147	denotes	Exon
T10410	43884-43899	SO_EXT:0000132	denotes	reverse primers
T10411	43911-43915	SO_EXT:0000147	denotes	Exon
T10412	43957-43961	SO_EXT:0000147	denotes	Exon
T10413	44003-44007	SO_EXT:0000147	denotes	Exon
T10414	44049-44053	SO_EXT:0000147	denotes	Exon
T10415	44093-44097	SO_EXT:0000147	denotes	Exon
T10416	44139-44145	NCBITaxon:9986	denotes	Rabbit
T10417	44146-44151	UBERON:0000955	denotes	brain
T10418	44152-44159	SO_EXT:0000610	denotes	poly A+
T10419	44157-44158	CHEBI_EXT:adenine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	A
T10420	44160-44164	CHEBI_SO_EXT:mRNA	denotes	mRNA
T10421	44166-44171	NCBITaxon:10088	denotes	mouse
T10422	44172-44178	UBERON:0000473	denotes	testis
T10423	44183-44188	NCBITaxon:9606	denotes	human
T10424	44189-44194	UBERON:0000955	denotes	brain
T10425	44201-44204	CHEBI_SO_EXT:RNA	denotes	RNA
T10426	44272-44293	GO:0001171	denotes	Reverse transcription
T10427	44368-44371	CHEBI_SO_EXT:RNA	denotes	RNA
T10428	44384-44391	SO_EXT:0000610	denotes	poly A+
T10429	44389-44390	CHEBI_EXT:adenine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group	denotes	A
T10430	44392-44396	CHEBI_SO_EXT:mRNA	denotes	mRNA
T10431	44426-44430	SO_EXT:cDNA	denotes	cDNA
T10432	44442-44454	SO_EXT:0000006	denotes	PCR products
T10433	44460-44466	SO_EXT:sequence_cloning_process	denotes	cloned
T10434	44517-44528	GO:0009294	denotes	transformed
T10435	44551-44556	CL_GO_EXT:cell	denotes	cells
T10436	44558-44565	SO_EXT:0000155	denotes	Plasmid
T10437	44566-44573	SO_EXT:0000667	denotes	inserts
T10438	44626-44636	CHEBI:33694	denotes	Biopolymer
T10937	44667-44677	CHEBI_SO_EXT:nucleotide	denotes	nucleotide
T10938	44678-44687	SO_EXT:biological_sequence	denotes	sequences
T10939	44688-44697	SO_EXT:biological_sequence	denotes	Sequences
T10940	44798-44810	NCBITaxon:9606	denotes	Homo sapiens
T10941	44811-44816	PR_EXT:000016006	denotes	TACC1
T10942	44823-44830	SO_EXT:0001060	denotes	isoform
T10943	44845-44857	NCBITaxon:10090	denotes	Mus musculus
T10944	44858-44863	PR_EXT:000016006	denotes	TACC1
T10945	44870-44877	SO_EXT:0001060	denotes	isoform
T10946	44892-44904	NCBITaxon:10090	denotes	Mus musculus
T10947	44905-44910	PR_EXT:000016006	denotes	TACC1
T10948	44916-44923	SO_EXT:0001060	denotes	isoform
T10949	44938-44950	NCBITaxon:10090	denotes	Mus musculus
T10950	44970-44991	NCBITaxon:9986	denotes	Oryctolagus cuniculus
T10951	44992-44997	PR_EXT:000016008	denotes	TACC3
T10952	45010-45021	NCBITaxon:7955	denotes	Danio rerio
T10953	45022-45027	PR_EXT:000016008	denotes	TACC3
T10954	45125-45140	NCBITaxon:10116	denotes	Rattus norvegus
T10955	45141-45146	PR_EXT:000016006	denotes	TACC1
T10956	45152-45159	SO_EXT:0001060	denotes	isoform
T10957	45174-45191	NCBITaxon:31033	denotes	Takifugu rubripes
T10958	45220-45237	NCBITaxon:31033	denotes	Takifugu rubripes
T10959	45257-45269	NCBITaxon:10090	denotes	Mus musculus
T10960	45289-45304	NCBITaxon:10116	denotes	Rattus norvegus
T10961	45324-45339	NCBITaxon:10116	denotes	Rattus norvegus
T10962	45359-45376	NCBITaxon:31033	denotes	Takifugu rubripes
T10963	45396-45411	NCBITaxon:10116	denotes	Rattus norvegus
T10964	45412-45417	PR_EXT:000016008	denotes	TACC3
T10965	45430-45443	NCBITaxon:9031	denotes	Gallus gallus
T10966	45444-45449	PR_EXT:000016008	denotes	TACC3
T10967	45462-45481	NCBITaxon:8364	denotes	Silurana tropicalis
T10968	45482-45487	PR_EXT:000016008	denotes	TACC3
T10969	45499-45516	NCBITaxon:31033	denotes	Takifugu rubripes
T10970	45517-45522	PR_EXT:000016008	denotes	TACC3
T10971	45535-45552	NCBITaxon:31033	denotes	Takifugu rubripes
T10972	45553-45558	PR_EXT:000001856	denotes	RHAMM
T10973	45571-45589	NCBITaxon:7719	denotes	Ciona intestinalis
T10974	45590-45595	PR_EXT:000001856	denotes	RHAMM
T10975	45608-45625	NCBITaxon:31033	denotes	Takifugu rubripes
T10976	45646-45663	NCBITaxon:31033	denotes	Takifugu rubripes
T10977	45664-45668	PR_EXT:000016579	denotes	TPM1
T10978	45681-45699	NCBITaxon:7719	denotes	Ciona intestinalis
T10979	45700-45705	PR_EXT:000009312	denotes	Kif3b
T10980	45718-45736	NCBITaxon:7719	denotes	Ciona intestinalis
T10981	45737-45741	PR_EXT:000009289	denotes	klp2
T11361	45827-45835	CHEBI_PR_EXT:protein	denotes	proteins
T11362	45847-45858	SO_EXT:0001080	denotes	coiled coil
T11363	45859-45866	SO_EXT:0000417	denotes	domains
T11364	45868-45875	CHEBI_PR_EXT:protein	denotes	protein
T11365	45876-45885	SO_EXT:biological_sequence	denotes	sequences
T11366	45955-45960	PR_EXT:000001856	denotes	RHAMM
T11367	46006-46017	NCBITaxon:7742	denotes	vertebrates
T11368	46041-46052	SO_EXT:0000855	denotes	orthologues
T11369	46062-46073	NCBITaxon:7712	denotes	urochordate
T11370	46074-46092	NCBITaxon:7719	denotes	Ciona intestinalis
T11371	46094-46117	NCBITaxon:7227	denotes	Drosophila melanogaster
T11372	46119-46129	NCBITaxon:6239	denotes	C. elegans
T11373	46134-46158	NCBITaxon:4932	denotes	Saccharomyces cerevisiae
T11374	46200-46208	SO_EXT:biological_sequence	denotes	sequence
T11375	46261-46268	NCBITaxon:species	denotes	Species
T11376	46299-46301	NCBITaxon:9606	denotes	hs
T11377	46303-46315	NCBITaxon:9606	denotes	Homo sapiens
T11378	46318-46320	NCBITaxon:10090	denotes	mm
T11379	46322-46334	NCBITaxon:10090	denotes	Mus musculus
T11380	46337-46339	NCBITaxon:10116	denotes	rn
T11381	46341-46356	NCBITaxon:10116	denotes	Rattus norvegus
T11382	46359-46361	NCBITaxon:9986	denotes	oc
T11383	46363-46384	NCBITaxon:9986	denotes	Oryctolagus cuniculus
T11384	46387-46389	NCBITaxon:9031	denotes	gg
T11385	46391-46404	NCBITaxon:9031	denotes	Gallus gallus
T11386	46407-46409	NCBITaxon:8355	denotes	xl
T11387	46411-46425	NCBITaxon:8355	denotes	Xenopus laevis
T11388	46428-46430	NCBITaxon:8364	denotes	st
T11389	46432-46451	NCBITaxon:8364	denotes	Silurana tropicalis
T11390	46454-46456	NCBITaxon:31033	denotes	tr
T11391	46458-46475	NCBITaxon:31033	denotes	Takifugu rubripes
T11392	46478-46480	NCBITaxon:7955	denotes	dr
T11393	46482-46493	NCBITaxon:7955	denotes	Danio rerio
T11394	46496-46498	NCBITaxon:7719	denotes	ci
T11395	46500-46518	NCBITaxon:7719	denotes	Ciona intestinalis
T11396	46521-46523	NCBITaxon:7227	denotes	dm
T11397	46525-46540	NCBITaxon:7227	denotes	D. melanogaster
T11398	46543-46545	NCBITaxon:6239	denotes	ce
T11399	46547-46557	NCBITaxon:6239	denotes	C. elegans
T11400	46560-46562	NCBITaxon:4932	denotes	sc
T11401	46564-46588	NCBITaxon:4932	denotes	Saccharomyces cerevisiae
T11402	46595-46604	SO_EXT:biological_sequence	denotes	sequences
T11403	46640-46647	CHEBI_PR_EXT:protein	denotes	protein
T11404	46711-46719	PR_EXT:O75410-1	denotes	hsTACC1A
T11405	46733-46741	PR_EXT:O95359-4	denotes	hsTACC2l
T11406	46753-46761	PR_EXT:O95359-1	denotes	hsTACC2s
T11407	46774-46781	PR_EXT:Q9Y6A5	denotes	hsTACC3
T11408	46795-46802	PR_EXT:Q9JJ11	denotes	mmTACC3
T11409	46871-46878	PR_EXT:P39723	denotes	scSPC72
T11410	46892-46899	PR_EXT:O75330	denotes	hsRHAMM
T11411	46913-46920	PR_EXT:Q00547	denotes	mmRHAMM
T11412	46934-46941	PR_EXT:P97779	denotes	rnRHAMM
T11413	46955-46962	PR_EXT:Q9W3V2	denotes	drRHAMM
T11414	47040-47046	PR_EXT:P09493	denotes	hsTPM1
T11415	47060-47066	PR_EXT:P58771	denotes	mmTPM1
T11416	47080-47086	PR_EXT:P04692	denotes	rnTPM1
T11417	47098-47104	PR_EXT:P13104	denotes	drTPM1
T11418	47152-47158	PR_EXT:P17536	denotes	scTPM1
T11419	47169-47175	PR_EXT:Q9NS87	denotes	hsKLP2
T11420	47188-47195	PR_EXT:Q7TSP2	denotes	rnKIF15
T11421	47227-47233	PR_EXT:P46863	denotes	dmKLP2
T11422	47267-47274	PR_EXT:Q9Y496	denotes	hsKIF3A
T11423	47285-47292	PR_EXT:P28741	denotes	mmKIF3A
T11424	47391-47398	PR_EXT:O15066	denotes	hsKIF3B
T11425	47412-47419	PR_EXT:Q61771	denotes	mmKIF3B
T11426	47454-47461	PR_EXT:P46867	denotes	dmKIF3B
T11427	47475-47482	PR_EXT:O14782	denotes	hsKIF3C
T11428	47496-47503	PR_EXT:O35066	denotes	mmKIF3C
T11429	47517-47524	PR_EXT:O55165	denotes	rnKIF3C
T11430	47565-47572	CHEBI_PR_EXT:protein	denotes	protein
T11431	47573-47582	SO_EXT:biological_sequence	denotes	sequences
T11432	47817-47825	CHEBI_PR_EXT:protein	denotes	proteins
T11433	48060-48068	SO_EXT:biological_sequence	denotes	sequence
T12057	48321-48326	PR_EXT:000016007	denotes	TACC2
T12058	48341-48346	PR_EXT:000016007	denotes	TACC2
T12059	48347-48351	SO_EXT:cDNA	denotes	cDNA
T12060	48356-48362	SO_EXT:sequence_cloning_process	denotes	cloned
T12061	48368-48371	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T12062	48372-48378	SO_EXT:sequence_fusion_entity_or_process	denotes	fusion
T12063	48379-48385	SO_EXT:0000440	denotes	vector
T12064	48439-48442	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T12065	48447-48450	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T12066	48451-48456	PR_EXT:000016007	denotes	TACC2
T12067	48457-48465	CHEBI_PR_EXT:protein	denotes	proteins
T12068	48471-48480	GO:0010467	denotes	expressed
T12069	48484-48491	NCBITaxon:562	denotes	E. coli
T12070	48521-48525	CHEBI:61448	denotes	IPTG
T12071	48552-48557	CL_GO_EXT:cell	denotes	Cells
T12072	48614-48618	CHEBI:9754	denotes	Tris
T12073	48619-48622	CHEBI:17883	denotes	HCl
T12074	48638-48642	CHEBI:26710	denotes	NaCl
T12075	48649-48653	CHEBI_EXT:EDTA	denotes	EDTA
T12076	48661-48679	CHEBI_GO_EXT:peptidase_or_protease_or_proteinase_inhibitor	denotes	Protease inhibitor
T12077	48706-48711	CL_GO_EXT:cell	denotes	cells
T12078	48717-48722	GO:0019835	denotes	lysed
T12079	48830-48839	GO_EXT:biological_movement_or_translocation_process	denotes	mobilized
T12080	48843-48854	CHEBI:16856	denotes	glutathione
T12081	48888-48892	CHEBI:9754	denotes	Tris
T12082	48893-48896	CHEBI:17883	denotes	HCl
T12083	48912-48916	CHEBI:26710	denotes	NaCl
T12084	48923-48927	CHEBI_EXT:EDTA	denotes	EDTA
T12085	48942-48946	SO_EXT:cDNA	denotes	cDNA
T12086	48951-48957	SO_EXT:sequence_cloning_process	denotes	cloned
T12087	49010-49017	CHEBI_PR_EXT:protein	denotes	protein
T12088	49051-49064	GO_EXT:transcription	denotes	transcription
T12089	49065-49076	GO:0006412	denotes	translation
T12090	49102-49114	CHEBI_EXT:radiolabel_process	denotes	radiolabeled
T12091	49120-49123	CHEBI:37983	denotes	35S
T12092	49124-49134	CHEBI_SO_EXT:methionine	denotes	methionine
T12093	49196-49206	GO:0006412	denotes	translated
T12094	49213-49220	CHEBI_PR_EXT:protein	denotes	protein
T12095	49238-49242	CHEBI:9754	denotes	Tris
T12096	49243-49246	CHEBI:17883	denotes	HCl
T12097	49262-49266	CHEBI:26710	denotes	NaCl
T12098	49273-49277	CHEBI_EXT:EDTA	denotes	EDTA
T12099	49312-49321	GO_EXT:biological_movement_or_translocation_process	denotes	mobilized
T12100	49322-49325	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T12101	49326-49331	PR_EXT:000016007	denotes	TACC2
T12102	49335-49338	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T12103	49353-49358	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bound
T12104	49411-49415	CHEBI:9754	denotes	Tris
T12105	49416-49419	CHEBI:17883	denotes	HCl
T12106	49435-49439	CHEBI:26710	denotes	NaCl
T12107	49446-49450	CHEBI_EXT:EDTA	denotes	EDTA
T12108	49458-49463	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	Bound
T12109	49464-49472	CHEBI_PR_EXT:protein	denotes	proteins
T12110	49542-49548	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T12111	49557-49561	CHEBI:9754	denotes	Tris
T12112	49562-49565	CHEBI:17883	denotes	HCl
T12113	49588-49599	CHEBI:16856	denotes	glutathione
T12114	49606-49614	CHEBI_PR_EXT:protein	denotes	proteins
T12115	49636-49639	CHEBI:8984	denotes	SDS
T12116	49640-49654	CHEBI_EXT:polyacrylamide	denotes	polyacrylamide
T12117	49711-49714	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T12118	49715-49721	SO_EXT:sequence_fusion_entity_or_process	denotes	fusion
T12119	49722-49729	CHEBI_PR_EXT:protein	denotes	protein
T12592	16379-16385	_FRAGMENT	denotes	region
T12593	16409-16422	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	on chromosome
T12594	16394-16398	PR_EXT:000008212	denotes	GPX3
T12595	16403-16408	PR_EXT:000011245	denotes	NKX2E
T12596	16412-16422	GO_SO_EXT:chromosome	denotes	chromosome
T12597	16477-16482	SO_EXT:0000704	denotes	genes
T12598	16483-16491	SO_EXT:sequence_insertion_process	denotes	inserted
T12599	16498-16509	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T12600	16544-16549	SO_EXT:0000704	denotes	genes
T12601	16585-16593	_FRAGMENT	denotes	syntenic
T12602	16612-16619	SO_EXT:0005858	denotes	regions
T12603	16594-16599	NCBITaxon:10088	denotes	mouse
T12604	16600-16619	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal regions
T12605	16641-16658	NCBITaxon:31033	denotes	Takifugu rubripes
T12606	16659-16668	SO_EXT:0001248	denotes	scaffolds
T12607	16712-16722	SO:0000857	denotes	homologous
T12608	16723-16727	SO_EXT:0000704	denotes	gene
T12609	16784-16794	SO:0000859	denotes	paralogous
T12610	16795-16800	SO_EXT:0000704	denotes	genes
T12784	20814-20831	NCBITaxon:31033	denotes	Takifugu rubripes
T12785	20836-20854	NCBITaxon:7719	denotes	Ciona intestinalis
T12786	20878-20885	SO_EXT:0001026	denotes	genomic
T12787	20886-20895	SO_EXT:0001248	denotes	scaffolds
T12788	20911-20928	NCBITaxon:31033	denotes	Takifugu rubripes
T12789	20951-20956	SO_EXT:0000704	denotes	genes
T12790	20958-20966	SO_EXT:0001248	denotes	Scaffold
T12791	20997-21001	SO_EXT:0000704	denotes	gene
T12792	21011-21016	SO_EXT:0000704	denotes	genes
T12793	21035-21045	SO_EXT:0000853	denotes	homologues
T12794	21049-21060	SO_EXT:0000855	denotes	orthologues
T12795	21080-21086	_FRAGMENT	denotes	arm of
T12796	21093-21103	SO_EXT:0000105	denotes	chromosome
T12797	21087-21092	NCBITaxon:9606	denotes	human
T12798	21093-21103	GO_SO_EXT:chromosome	denotes	chromosome
T12799	21122-21130	SO_EXT:0001248	denotes	scaffold
T12800	21218-21223	PR_EXT:000016006	denotes	TACC1
T12801	21224-21229	PR_EXT:000016007	denotes	TACC2
T12802	21230-21249	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T12803	21272-21280	SO_EXT:0001248	denotes	scaffold
T12804	21301-21312	SO_EXT:0000855	denotes	orthologues
T12805	21316-21321	SO_EXT:0000704	denotes	genes
T12806	21350-21356	_FRAGMENT	denotes	arm of
T12807	21363-21373	SO_EXT:0000105	denotes	chromosome
T12808	21357-21362	NCBITaxon:9606	denotes	human
T12809	21363-21373	GO_SO_EXT:chromosome	denotes	chromosome
T12810	21382-21400	NCBITaxon:7719	denotes	Ciona intestinalis
T12811	21421-21426	SO_EXT:0000704	denotes	genes
T12812	21436-21455	SO_EXT:0000854	denotes	paralogous segments
T12813	21459-21464	NCBITaxon:9606	denotes	human
T12970	21496-21503	SO_EXT:0001026	denotes	Genomic
T12971	21526-21531	SO_EXT:0000704	denotes	genes
T12972	21533-21542	SO_EXT:biological_conservation_process_or_quality	denotes	Conserved
T12973	21560-21564	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T12974	21565-21572	CHEBI_PR_EXT:protein	denotes	protein
T12975	21588-21593	NCBITaxon:9606	denotes	human
T12976	21599-21607	CHEBI_PR_EXT:protein	denotes	proteins
T12977	21627-21633	SO_EXT:sequence_repeat_unit_or_region	denotes	repeat
T12978	21637-21642	NCBITaxon:9606	denotes	human
T12979	21643-21648	PR_EXT:000016006	denotes	TACC1
T12980	21663-21667	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T12981	21668-21673	PR_EXT:000017527	denotes	GAS41
T12982	21712-21718	SO_EXT:0000417	denotes	domain
T12983	21719-21724	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T12984	21725-21731	PR_EXT:000005512	denotes	ch-TOG
T12985	21751-21765	PR_EXT:000035365	denotes	Aurora kinases
T12986	21758-21765	GO_EXT:0016301	denotes	kinases
T12987	21773-21780	NCBITaxon:species	denotes	species
T12988	21804-21809	SO_EXT:sequence_or_structure_motif	denotes	motif
T12989	21832-21839	SO_EXT:sequence_coding_function	denotes	encoded
T12990	21850-21855	SO_EXT:0000147	denotes	exons
T12991	21868-21873	SO_EXT:0000704	denotes	genes
T12992	21899-21906	SO_EXT:0001060	denotes	isoform
T12993	21916-21920	SO_EXT:0000704	denotes	gene
T13160	27467-27487	GO:0000380	denotes	Alternative splicing
T13161	27495-27500	NCBITaxon:9606	denotes	human
T13162	27501-27506	PR_EXT:000016006	denotes	TACC1
T13163	27507-27511	SO_EXT:0000704	denotes	gene
T13164	27524-27530	GO:0008380	denotes	splice
T13165	27524-27539	SO_EXT:alternative_splice_variant	denotes	splice variants
T13166	27565-27570	NCBITaxon:9606	denotes	human
T13167	27571-27576	PR_EXT:000016006	denotes	TACC1
T13168	27625-27631	GO:0008380	denotes	splice
T13169	27625-27640	SO_EXT:alternative_splice_variant	denotes	splice variants
T13170	27674-27676	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	rt
T13171	27693-27698	NCBITaxon:9606	denotes	human
T13172	27699-27704	UBERON:0000955	denotes	brain
T13173	27705-27708	CHEBI_SO_EXT:RNA	denotes	RNA
T13174	27715-27735	GO:0000380	denotes	Alternative splicing
T13175	27739-27744	PR_EXT:000016006	denotes	TACC1
T13176	27752-27757	NCBITaxon:9606	denotes	human
T13177	27758-27763	UBERON:0000955	denotes	brain
T13178	27765-27767	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	rt
T13179	27790-27798	GO:0008380	denotes	splicing
T13180	27806-27823	SO_EXT:0000198	denotes	untranslated exon
T13181	27808-27818	GO:0006412	denotes	translated
T13182	27830-27834	SO_EXT:0000147	denotes	exon
T13183	27885-27895	CHEBI_SO_EXT:methionine	denotes	methionine
T13184	27912-27919	SO_EXT:sequence_variant_entity	denotes	Variant
T13185	27940-27944	SO_EXT:0000147	denotes	Exon
T13186	27953-27960	GO:0008380	denotes	splices
T13187	27964-27968	SO_EXT:0000147	denotes	exon
T13188	27985-27990	PR_EXT:000009965	denotes	L-Sm7
T13189	27991-27998	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T13190	27999-28004	SO_EXT:sequence_or_structure_motif	denotes	motif
T13191	28006-28013	SO_EXT:sequence_variant_entity	denotes	variant
T13192	28037-28045	SO_EXT:sequence_variant_entity	denotes	Variants
T13193	28064-28070	SO_EXT:sequence_deletion_process	denotes	delete
T13194	28071-28076	SO_EXT:0000147	denotes	exons
T13195	28097-28104	SO_EXT:sequence_variant_entity	denotes	variant
T13196	28143-28150	GO:0005634	denotes	nuclear
T13197	28143-28171	SO_EXT:0001528	denotes	nuclear localization signals
T13198	28151-28163	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localization
T13199	28181-28188	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T13200	28189-28196	SO_EXT:0000417	denotes	domains
T13201	28201-28206	PR_EXT:000017527	denotes	GAS41
T13202	28211-28221	PR_EXT:000029784	denotes	PCTAIRE2BP
T13203	28229-28237	SO_EXT:sequence_variant_entity	denotes	variants
T13204	28260-28266	SO_EXT:0000417	denotes	domain
T13205	28299-28303	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T13206	28307-28313	PR_EXT:000005512	denotes	ch-TOG
T13207	28318-28333	PR_EXT:000004515	denotes	Aurora A kinase
T13208	28327-28333	GO_EXT:0016301	denotes	kinase
T13209	28341-28351	GO:0005813	denotes	centrosome
T13210	28642-28643	CHEBI_SO_EXT:base	denotes	b
T13586	31839-31847	CHEBI_PR_EXT:protein	denotes	proteins
T13587	31859-31869	NCBITaxon:6239	denotes	C. elegans
T13588	31874-31889	NCBITaxon:7227	denotes	D. melanogaster
T13589	31896-31906	NCBITaxon:6239	denotes	C. elegans
T13590	32069-32074	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T13591	32119-32128	GO:0000785	denotes	chromatin
T13592	32119-32139	GO:0006338	denotes	chromatin remodeling
T13593	32140-32149	GO:0032991	denotes	complexes
T13594	32151-32158	GO:0016514	denotes	SWI/SNF
T13595	32163-32170	PR_EXT:000043452	denotes	histone
T13596	32163-32170	CHEBI:15358	denotes	histone
T13597	32163-32189	GO_EXT:0004402	denotes	histone acetyltransferases
T13598	32192-32195	CHEBI_SO_EXT:DNA	denotes	DNA
T13599	32192-32209	GO:0006281	denotes	DNA damage repair
T13600	32225-32230	PR_EXT:RAD23	denotes	RAD23
T13601	32237-32240	CHEBI_SO_EXT:RNA	denotes	RNA
T13602	32237-32249	GO:0008380	denotes	RNA splicing
T13603	32237-32240	_FRAGMENT	denotes	RNA
T13604	32251-32260	GO:0050658	denotes	transport
T13605	32265-32278	GO:0006412	denotes	translational
T13606	32325-32335	NCBITaxon:7742	denotes	vertebrate
T13607	32403-32410	GO:0005634	denotes	nuclear
T13608	32411-32418	CHEBI_GO_EXT:hormone	denotes	hormone
T13609	32419-32427	GO_EXT:0004872	denotes	receptor
T13610	32428-32432	PR_EXT:000014373	denotes	RXRβ
T13611	32573-32592	SO_EXT:0000854	denotes	paralogous segments
T13612	32694-32704	NCBITaxon:7742	denotes	Vertebrate
T13613	32799-32809	NCBITaxon:7742	denotes	vertebrate
T13614	32810-32819	SO_EXT:0000853	denotes	homologue
T13615	32883-32896	PR_EXT:000035365	denotes	Aurora kinase
T13616	32890-32896	GO_EXT:0016301	denotes	kinase
T13860	38453-38459	PR_EXT:000016007	denotes	TACC2s
T13861	38494-38497	CHEBI:8984	denotes	SDS
T13862	38498-38512	CHEBI_EXT:polyacrylamide	denotes	polyacrylamide
T13863	38531-38541	GO:0006412	denotes	translated
T13864	38548-38557	SO_EXT:engineered_biological_sequence	denotes	construct
T13865	38575-38578	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T13866	38579-38584	PR_EXT:000016007	denotes	TACC2
T13867	38597-38600	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T13868	38640-38650	GO:0006412	denotes	translated
T13869	38651-38654	GO_EXT:0004886	denotes	RXR
T13870	38651-38656	PR_EXT:000014373	denotes	RXR-β
T13871	38657-38664	CHEBI_PR_EXT:protein	denotes	protein
T13872	38765-38768	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T13873	38769-38774	PR_EXT:000016007	denotes	TACC2
T13874	38779-38782	GO_PR_EXT:glutathione_S_transferase	denotes	GST
T7077	30635-30640	NCBITaxon_EXT:yeast	denotes	Yeast
T12459	6304-6315	SO_EXT:0001080	denotes	coiled coil
T12460	6316-6324	CHEBI_PR_EXT:protein	denotes	proteins
T12461	6449-6460	SO_EXT:0001080	denotes	coiled coil
T12462	6472-6480	CHEBI_PR_EXT:protein	denotes	proteins
T12463	6502-6513	SO_EXT:0001080	denotes	coiled coil
T12464	6545-6550	PR_EXT:000001856	denotes	RHAMM
T12465	6583-6588	PR_EXT:000001856	denotes	RHAMM
T12466	6589-6597	CHEBI_PR_EXT:protein	denotes	proteins
T12467	6679-6687	CHEBI_PR_EXT:protein	denotes	proteins
T12468	6709-6717	CHEBI_PR_EXT:protein	denotes	proteins
T12584	16182-16188	SO:0000987	denotes	Linear
T12585	16205-16209	SO_EXT:0000704	denotes	gene
T12586	16238-16254	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal loci
T12587	16262-16266	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T12588	16267-16272	SO_EXT:0000704	denotes	genes
T12589	16276-16282	NCBITaxon:9606	denotes	humans
T12590	16284-16294	SO:0000859	denotes	Paralogous
T12591	16295-16300	SO_EXT:0000704	denotes	genes
T7076	30553-30568	NCBITaxon:7227	denotes	D. melanogaster
T7078	30691-30696	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binds
T7079	30700-30710	NCBITaxon:6239	denotes	C. elegans
T7080	30700-30717	PR_EXT:Q27365	denotes	C. elegans lin15A
T7081	30700-30710	_FRAGMENT	denotes	C. elegans
T7082	30719-30724	PR_EXT:P34427	denotes	lin36
T7083	30729-30734	PR_EXT:000009822	denotes	lin37
T7084	30747-30755	CHEBI_PR_EXT:protein	denotes	proteins
T7085	30756-30762	GO:0030674	denotes	bridge
T7086	30794-30806	GO:0005856	denotes	cytoskeleton
T7087	30811-30822	GO:0005874	denotes	microtubule
T7088	30864-30872	GO:0005840	denotes	ribosome
T7089	30878-30885	PR_EXT:000043452	denotes	histone
T7090	30878-30885	CHEBI:15358	denotes	histone
T7091	30878-30897	GO_EXT:0004407	denotes	histone deacetylase
T7092	30898-30907	GO:0000785	denotes	chromatin
T7093	30898-30918	GO:0006338	denotes	chromatin remodeling
T7094	30937-30942	PR_EXT:000006937	denotes	egr-1
T7095	30947-30953	PR_EXT:P90916	denotes	lin-53
T7096	30959-30969	NCBITaxon:6239	denotes	C. elegans
T7097	30970-30980	SO_EXT:0000853	denotes	homologues
T7098	30988-30993	NCBITaxon:9606	denotes	human
T7099	30994-30999	PR_EXT:000010707	denotes	MTA-1
T7100	31004-31010	PR_EXT:000013776	denotes	RbAP48
T7101	31020-31033	GO_EXT:transcription	denotes	transcription
T7102	31020-31041	GO_EXT:transcription_factor	denotes	transcription factors
T7103	31054-31058	PR_EXT:P34766	denotes	PAL1
T7104	31076-31083	GO:0005634	denotes	nuclear
T7105	31084-31091	CHEBI_GO_EXT:hormone	denotes	hormone
T7106	31092-31100	GO_EXT:0004872	denotes	receptor
T1435	4968-4978	NCBITaxon:7742	denotes	vertebrate
T1436	4983-4995	NCBITaxon_EXT:invertebrate	denotes	invertebrate
T1437	5005-5013	SO_EXT:biological_sequence	denotes	Sequence
T1438	5060-5066	SO_EXT:0001026	denotes	genome
T1439	5148-5153	PR_EXT:000001856	denotes	RHAMM
T1440	5154-5165	SO_EXT:0000855	denotes	orthologues
T1441	5192-5203	SO_EXT:0001080	denotes	coiled coil
T3949	14613-14633	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T3950	14654-14659	SO_EXT:0000704	denotes	genes
T3951	14689-14693	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T3952	14694-14699	SO_EXT:0000704	denotes	genes
T3953	14730-14740	NCBITaxon:7742	denotes	vertebrate
T3954	14741-14746	PR_EXT:000016006	denotes	TACC1
T3955	14749-14754	SO_EXT:0000704	denotes	genes
T3956	14791-14810	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal regions
T3957	14826-14830	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T3958	14831-14835	SO_EXT:0000704	denotes	gene
T3959	14846-14852	NCBITaxon:9606	denotes	humans
T3960	14854-14859	NCBITaxon:10088	denotes	mouse
T3961	14868-14876	NCBITaxon:6656	denotes	arthopod
T3962	14877-14892	NCBITaxon:7227	denotes	D. melanogaster
T3963	14911-14923	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T3964	14927-14937	_FRAGMENT	denotes	paralogous
T3965	14950-14958	SO_EXT:0000854	denotes	segments
T3966	14938-14958	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T3967	14973-14982	NCBITaxon:1	denotes	organisms
T3968	15082-15101	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T3969	15106-15116	SO_EXT:sequence_duplication_process	denotes	duplicated
T3970	15130-15140	NCBITaxon:7742	denotes	vertebrate
T3971	15167-15178	SO_EXT:sequence_duplication_entity_or_process	denotes	duplication
T3972	15201-15206	NCBITaxon:9606	denotes	human
T4005	16854-16866	SO_EXT:biological_conservation_process_or_quality	denotes	conservation
T4090	19132-19142	_FRAGMENT	denotes	paralogous
T4091	19155-19162	SO_EXT:0000854	denotes	segment
T4092	19143-19162	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segment
T4093	19164-19173	SO_EXT:biological_conservation_process_or_quality	denotes	Conserved
T4094	19174-19184	SO:0000859	denotes	paralogous
T4095	19240-19245	SO_EXT:0000704	denotes	genes
T4096	19278-19285	SO_EXT:0001026	denotes	genomic
T4097	19286-19292	SO_EXT:0000149	denotes	contig
T4098	19374-19384	_FRAGMENT	denotes	paralogous
T4099	19397-19405	SO_EXT:0000854	denotes	segments
T4100	19385-19405	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal segments
T4101	19422-19433	NCBITaxon:7742	denotes	vertebrates
T4102	19452-19458	SO_EXT:0001026	denotes	genome
T4103	19466-19477	NCBITaxon:7712	denotes	urochordate
T4104	19478-19493	NCBITaxon:7719	denotes	C. intestinalis
T4105	19518-19529	SO_EXT:0000855	denotes	orthologues
T4106	19533-19537	GO_PR_EXT:fibroblast_growth_factor_receptor	denotes	FGFR
T4107	19543-19548	PR_EXT:000030426	denotes	WHSC1
T4108	19550-19566	GO_EXT:0004180	denotes	carboxypeptidase
T4109	19550-19568	PR_EXT:000005841	denotes	carboxypeptidase Z
T4110	19604-19605	CHEBI_SO_EXT:base	denotes	b
T4111	19620-19635	NCBITaxon:7719	denotes	C. intestinalis
T4112	19636-19642	SO_EXT:0001026	denotes	genome
T4113	19651-19656	NCBITaxon:9606	denotes	human
T4114	19657-19668	SO_EXT:0000855	denotes	orthologues
T4115	19693-19712	SO_EXT:0000854	denotes	paralogous segments
T4116	19816-19821	SO_EXT:0000704	denotes	genes
T4117	19831-19841	NCBITaxon:7742	denotes	vertebrate
T4118	19842-19861	SO_EXT:0000854	denotes	paralogous segments
R8157	T12593	T12592	_lexicallyChainedTo	on chromosome,region
R8158	T12602	T12601	_lexicallyChainedTo	regions,syntenic
R313	T656	T655	_lexicallyChainedTo	chromosome,arm of
R314	T660	T659	_lexicallyChainedTo	regions,paralogous
R315	T663	T662	_lexicallyChainedTo	chromosomes,regions on
R810	T1582	T1581	_lexicallyChainedTo	chromosome,region of
R2438	T3965	T3964	_lexicallyChainedTo	segments,paralogous
R2439	T3981	T3980	_lexicallyChainedTo	segments,paralogous
R2440	T4084	T4083	_lexicallyChainedTo	chromosome,regions of
R2441	T4091	T4090	_lexicallyChainedTo	segment,paralogous
R2442	T4099	T4098	_lexicallyChainedTo	segments,paralogous
R4062	T6313	T6312	_lexicallyChainedTo	organism,development of
R4063	T6376	T6375	_lexicallyChainedTo	metabolism,cellular
R4425	T7082	T7081	_lexicallyChainedTo	lin36,C. elegans
R5174	T8231	T8230	_lexicallyChainedTo	protein,binding site for
R5175	T8235	T8234	_lexicallyChainedTo	translation,control of
R5176	T8255	T8254	_lexicallyChainedTo	transport,RNA
R6477	T10093	T10092	_lexicallyChainedTo	segments,paralogous
R8280	T12796	T12795	_lexicallyChainedTo	chromosome,arm of
R8281	T12807	T12806	_lexicallyChainedTo	chromosome,arm of
R8790	T13604	T13603	_lexicallyChainedTo	transport,RNA

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T62	49-55	CHEBI:37527	denotes	acidic
T63	56-67	SO:0001080	denotes	coiled coil
T64	68-73	SO:0000704	denotes	genes
T65	123-132	NCBITaxon:1	denotes	organisms
T66	177-181	SO:0000704	denotes	gene
T67	240-244	SO:0000704	denotes	gene
T68	290-298	SO:0000853	denotes	homologs
T69	344-350	CHEBI:37527	denotes	acidic
T70	351-362	SO:0001080	denotes	coiled coil
T71	370-374	SO:0000704	denotes	gene
T72	397-406	NCBITaxon:1	denotes	organisms
T73	421-424	NCBITaxon:9606	denotes	man
T74	618-625	SO:0001026	denotes	genomic
T75	688-697	NCBITaxon:1	denotes	organisms
T76	788-799	SO:0001080	denotes	coiled coil
T77	849-855	NCBITaxon:9986	denotes	rabbit
T78	869-879	SO:0000855	denotes	orthologue
T79	883-888	NCBITaxon:9606	denotes	human
T80	889-894	PR:000016008	denotes	TACC3
T81	900-905	PR:000001856	denotes	RHAMM
T82	930-941	SO:0001080	denotes	coiled coil
T83	1032-1042	NCBITaxon:6239	denotes	C. elegans
T84	1047-1062	NCBITaxon:7227	denotes	D. melanogaster
T85	1212-1217	NCBITaxon:9606	denotes	human
T86	1218-1223	PR:000016007	denotes	TACC2
T87	1231-1238	GO:0005634	denotes	nuclear
T88	1256-1260	PR:000014373	denotes	RXRβ
T89	1347-1358	GO:0005813	denotes	centrosomal
T90	1359-1366	GO:0007067	denotes	mitotic
T91	1359-1374	GO:0072686	denotes	mitotic spindle
T92	1422-1431	GO:0032991	denotes	complexes
T93	1452-1463	GO:0006412	denotes	translation
T94	1465-1479	GO:0006396	denotes	RNA processing
T95	1528-1536	GO:0030674	denotes	bridging
T96	1668-1677	GO:0032991	denotes	complexes
T97	1705-1712	GO:0005634	denotes	nuclear
T98	1732-1737	PR:000017527	denotes	GAS41
T99	1895-1905	GO:0005813	denotes	centrosome
T100	1969-1978	GO:0000785	denotes	chromatin
T101	1969-1989	GO:0006338	denotes	chromatin remodeling
T102	2031-2040	GO:0032991	denotes	complexes
T563	2091-2100	NCBITaxon:1	denotes	organisms
T564	2144-2148	SO:0000704	denotes	gene
T565	2235-2240	SO:0000704	denotes	genes
T566	2315-2319	SO:0000147	denotes	exon
T567	2338-2342	SO:0000704	denotes	gene
T568	2353-2358	SO:0000704	denotes	genes
T569	2483-2489	SO:0001026	denotes	genome
T570	2513-2518	NCBITaxon:9606	denotes	human
T571	2520-2525	NCBITaxon:10088	denotes	mouse
T572	2527-2530	NCBITaxon:10114	denotes	rat
T573	2532-2541	NCBITaxon:7215	denotes	fruit fly
T574	2546-2555	NCBITaxon:6231	denotes	nematodes
T575	2628-2633	SO:0000704	denotes	genes
T576	2671-2679	NCBITaxon:1	denotes	organism
T577	2793-2798	SO:0000704	denotes	genes
T578	2803-2807	SO:0000704	denotes	gene
T579	2831-2835	SO:0000704	denotes	gene
T580	2854-2863	NCBITaxon:1	denotes	organisms
T581	2931-2938	SO:0001026	denotes	genomic
T582	3060-3064	SO:0000704	denotes	gene
T583	3120-3126	CHEBI:37527	denotes	acidic
T584	3127-3138	SO:0001080	denotes	coiled coil
T585	3139-3143	SO:0000704	denotes	gene
T586	3145-3150	PR:000016006	denotes	TACC1
T587	3196-3206	GO:0010467	denotes	expression
T588	3196-3210	SO:0001428	denotes	expression map
T589	3233-3239	_FRAGMENT	denotes	arm of
T590	3246-3256	SO:0000105	denotes	chromosome
T591	3240-3245	NCBITaxon:9606	denotes	human
T592	3342-3352	_FRAGMENT	denotes	paralogous
T593	3365-3372	SO:0000854	denotes	regions
T594	3376-3381	NCBITaxon:9606	denotes	human
T595	3450-3454	SO:0000704	denotes	gene
T596	3534-3538	SO:0000704	denotes	gene
T597	3546-3557	NCBITaxon:33317	denotes	protostomes
T598	3558-3579	NCBITaxon:6239	denotes	Caenorhabitis elegans
T599	3585-3608	NCBITaxon:7227	denotes	Drosophila melanogaster
T600	3672-3677	SO:0000704	denotes	genes
T601	3753-3764	NCBITaxon:7742	denotes	vertebrates
T602	3818-3822	SO:0000704	denotes	gene
T603	3898-3903	SO:0000704	denotes	genes
T604	3907-3913	NCBITaxon:9606	denotes	humans
T605	3970-3980	NCBITaxon:7742	denotes	vertebrate
T606	3981-3987	SO:0001026	denotes	genome
T607	4046-4057	NCBITaxon:7742	denotes	vertebrates
T608	4105-4109	SO:0000704	denotes	gene
T609	4129-4134	PR:000001451	denotes	FGFR4
T610	4138-4148	NCBITaxon:7742	denotes	vertebrate
T611	4149-4156	SO:0001026	denotes	genomes
T612	4190-4195	SO:0000704	denotes	genes
T613	4216-4222	NCBITaxon:9606	denotes	humans
T614	4245-4250	NCBITaxon:10088	denotes	mouse
T615	4256-4270	NCBITaxon:8355	denotes	Xenopus laevis
T616	4276-4291	NCBITaxon:7227	denotes	D. melanogaster
T617	4301-4311	NCBITaxon:6239	denotes	C. elegans
T618	4378-4399	NCBITaxon:9986	denotes	Oryctolagus cuniculus
T619	4414-4419	NCBITaxon:9606	denotes	human
T620	4420-4425	PR:000001856	denotes	RHAMM
T621	4638-4647	NCBITaxon:1	denotes	organisms
T622	4649-4670	GO:0000380	denotes	alternatively spliced
T623	4750-4755	SO:0000704	denotes	genes
T624	4789-4800	SO:0001080	denotes	coiled coil
T1319	4968-4978	NCBITaxon:7742	denotes	vertebrate
T1320	5060-5066	SO:0001026	denotes	genome
T1321	5148-5153	PR:000001856	denotes	RHAMM
T1322	5154-5165	SO:0000855	denotes	orthologues
T1323	5192-5203	SO:0001080	denotes	coiled coil
T1324	5236-5243	NCBITaxon:species	denotes	species
T1325	5304-5309	SO:0000704	denotes	genes
T1326	5443-5452	NCBITaxon:1	denotes	organisms
T1327	5546-5556	NCBITaxon:7742	denotes	vertebrate
T1328	5557-5564	NCBITaxon:species	denotes	species
T1329	5570-5583	NCBITaxon:7586	denotes	echinodermate
T1330	5584-5613	NCBITaxon:7668	denotes	Strongylocentrotus purpuratus
T1331	5622-5632	NCBITaxon:33317	denotes	protostome
T1332	5633-5639	NCBITaxon:6960	denotes	insect
T1337	5837-5846	NCBITaxon:1	denotes	organisms
T1338	5888-5893	SO:0000704	denotes	genes
T1339	5996-6006	NCBITaxon:33213	denotes	bilaterian
T1340	6007-6016	NCBITaxon:33208	denotes	metazoans
T1341	6026-6034	NCBITaxon:6073	denotes	Cnidaria
T1342	6038-6046	NCBITaxon:6040	denotes	Porifera
T1343	6101-6110	NCBITaxon:1	denotes	organisms
T1344	6168-6174	SO:0000417	denotes	domain
T1345	6207-6215	NCBITaxon:33208	denotes	metazoan
T1346	6216-6225	NCBITaxon:1	denotes	organisms
T1347	6738-6739	SO:0001080	denotes	c
T1348	6748-6750	NCBITaxon:7711	denotes	ra
T1349	6777-6781	SO:0000704	denotes	gene
T1350	6804-6810	SO:0001026	denotes	genome
T1351	6818-6829	NCBITaxon:7712	denotes	urochordate
T1352	6830-6848	NCBITaxon:7719	denotes	Ciona intestinalis
T1353	6907-6926	NCBITaxon:7729	denotes	Halocynthia rortezi
T1354	6927-6930	SO:0000345	denotes	EST
T1355	7003-7007	SO:0000704	denotes	gene
T1356	7027-7035	NCBITaxon:7711	denotes	chordate
T1357	7091-7099	NCBITaxon:7711	denotes	chordate
T1358	7100-7106	SO:0001026	denotes	genome
T1359	7214-7222	NCBITaxon:7711	denotes	chordate
T1360	7223-7229	SO:0001026	denotes	genome
T1361	7304-7309	SO:0000704	denotes	genes
T1362	7380-7385	SO:0000704	denotes	genes
T1363	7418-7428	NCBITaxon:7742	denotes	vertebrate
T1364	7429-7435	SO:0001026	denotes	genome
T1365	7459-7469	NCBITaxon:31031	denotes	pufferfish
T1366	7470-7487	NCBITaxon:31033	denotes	Takifugu rubripes
T1367	7500-7505	SO:0000704	denotes	genes
T1368	7527-7532	NCBITaxon:9606	denotes	human
T1369	7533-7538	PR:000016006	denotes	TACC1
T1370	7586-7593	SO:0001026	denotes	genomic
T1371	7643-7648	SO:0000704	denotes	genes
T1372	7686-7690	SO:0000704	denotes	gene
T1373	7709-7714	PR:000016008	denotes	TACC3
T1374	7743-7748	SO:0000704	denotes	genes
T1375	7768-7779	NCBITaxon:31033	denotes	T. rubripes
T1376	7795-7800	SO:0000704	denotes	genes
T1377	7821-7832	NCBITaxon:31033	denotes	T. rubripes
T1378	7833-7844	SO:0000855	denotes	orthologues
T1379	7848-7853	NCBITaxon:9606	denotes	human
T1380	7854-7859	PR:000016007	denotes	TACC2
T1381	7864-7869	PR:000016008	denotes	TACC3
T1382	7894-7899	SO:0000704	denotes	genes
T1383	7951-7956	PR:000016006	denotes	TACC1
T1384	7995-8005	SO:0000857	denotes	homologous
T1385	8094-8098	SO:0000704	denotes	gene
T1386	8116-8121	SO:0000147	denotes	exons
T1387	8153-8161	NCBITaxon:31032	denotes	Takifugu
T1388	8162-8170	SO:0001248	denotes	Scaffold
T1389	8244-8248	SO:0000704	denotes	gene
T1390	8310-8315	SO:0000147	denotes	exons
T1391	8348-8354	SO:0000188	denotes	intron
T1392	8355-8359	SO:0000147	denotes	exon
T1393	8398-8402	SO:0000704	denotes	gene
T1394	8453-8463	NCBITaxon:31031	denotes	pufferfish
T1395	8543-8551	NCBITaxon:1	denotes	organism
T1396	8715-8720	SO:0000704	denotes	genes
T1397	8806-8813	NCBITaxon:32443	denotes	teleost
T1398	8814-8819	PR:000016006	denotes	TACC1
T1399	8860-8867	SO:0001026	denotes	genomic
T1400	8901-8908	NCBITaxon:32443	denotes	teleost
T1401	8946-8957	NCBITaxon:31033	denotes	T. rubripes
T1402	9022-9027	PR:000016008	denotes	TACC3
T1403	9073-9083	NCBITaxon:7742	denotes	vertebrate
T1404	9084-9091	SO:0001026	denotes	genomic
T1405	9127-9138	NCBITaxon:7742	denotes	vertebrates
T1406	9168-9174	GO:0008380	denotes	splice
T1407	9187-9192	PR:000016006	denotes	TACC1
T1408	9197-9202	PR:000016007	denotes	TACC2
T1409	9206-9218	NCBITaxon:10090	denotes	Mus musculus
T1410	9268-9279	SO:0000855	denotes	orthologues
T1411	9283-9288	PR:000016006	denotes	TACC1
T1412	9296-9311	NCBITaxon:10116	denotes	Rattus norvegus
T1413	9359-9364	NCBITaxon:10088	denotes	mouse
T1414	9365-9377	GO:0000805	denotes	chromosome X
T1415	9384-9388	SO:0000704	denotes	gene
T1416	9415-9420	NCBITaxon:10088	denotes	mouse
T1417	9421-9426	PR:000016006	denotes	TACC1
T1418	9468-9473	NCBITaxon:10088	denotes	mouse
T1419	9528-9534	SO:0000188	denotes	intron
T1420	9552-9562	GO:0010467	denotes	expression
T2546	11823-11829	NCBITaxon:9986	denotes	rabbit
T2505	10012-10022	NCBITaxon:7742	denotes	vertebrate
T2506	10023-10028	PR:000016008	denotes	TACC3
T2507	10029-10040	SO:0000855	denotes	orthologues
T2508	10105-10110	PR:000016008	denotes	TACC3
T2509	10111-10122	SO:0000855	denotes	orthologues
T2510	10214-10218	SO:0000704	denotes	gene
T2511	10290-10294	SO:0000704	denotes	gene
T2512	10334-10344	NCBITaxon:7742	denotes	vertebrate
T2513	10381-10392	NCBITaxon:31033	denotes	T. rubripes
T2514	10394-10401	NCBITaxon:9989	denotes	rodents
T2515	10406-10412	NCBITaxon:9606	denotes	humans
T2516	10438-10448	NCBITaxon:7742	denotes	vertebrate
T2517	10449-10454	PR:000016008	denotes	TACC3
T2518	10505-10512	SO:0001026	denotes	genomic
T2519	10564-10568	SO:0000704	denotes	gene
T2520	10678-10699	NCBITaxon:9986	denotes	Oryctolagus cuniculus
T2521	10822-10827	PR:000016008	denotes	TACC3
T2522	10877-10881	SO:0000704	denotes	gene
T2523	10907-10917	SO:0000673	denotes	transcript
T2524	11025-11030	NCBITaxon:9606	denotes	human
T2525	11035-11040	NCBITaxon:10088	denotes	mouse
T2526	11041-11046	PR:000016008	denotes	TACC3
T2527	11104-11110	NCBITaxon:9986	denotes	rabbit
T2528	11111-11116	PR:000016008	denotes	TACC3
T2529	11181-11187	NCBITaxon:9986	denotes	rabbit
T2530	11188-11193	PR:000016008	denotes	TACC3
T2531	11237-11242	NCBITaxon:9606	denotes	human
T2532	11247-11252	NCBITaxon:10088	denotes	mouse
T2533	11253-11258	PR:000016008	denotes	TACC3
T2534	11335-11340	NCBITaxon:9606	denotes	human
T2535	11345-11350	NCBITaxon:10088	denotes	mouse
T2536	11351-11356	PR:000016008	denotes	TACC3
T2537	11463-11468	SO:0000704	denotes	genes
T2538	11484-11493	SO:0000993	denotes	consensus
T2539	11510-11516	SO:0000112	denotes	primer
T2540	11629-11634	PR:000016008	denotes	TACC3
T2541	11646-11654	NCBITaxon:9443	denotes	primates
T2542	11659-11666	NCBITaxon:9989	denotes	rodents
T2543	11679-11685	SO:0000112	denotes	primer
T2544	11731-11737	SO:0000112	denotes	primer
T2545	11806-11817	SO:0000006	denotes	PCR product
T2547	11830-11835	UBERON:0000955	denotes	brain
T2548	11897-11906	SO:0000993	denotes	consensus
T2549	11920-11922	SO:0000028	denotes	bp
T2550	11948-11958	SO:0000673	denotes	transcript
T2551	12115-12133	GO:0000380	denotes	alternative splice
T2552	12185-12190	PR:000016008	denotes	TACC3
T2553	12191-12195	SO:0000704	denotes	gene
T2554	12234-12240	NCBITaxon:9986	denotes	rabbit
T2555	12252-12262	SO:0000673	denotes	transcript
T2556	12275-12281	NCBITaxon:9986	denotes	rabbit
T2557	12305-12325	SO:0002138	denotes	predicted transcript
T2558	12338-12343	PR:000016008	denotes	TACC3
T2559	12690-12696	NCBITaxon:9986	denotes	rabbit
T2560	12713-12719	NCBITaxon:9986	denotes	rabbit
T2561	12720-12725	PR:000016008	denotes	TACC3
T2562	12836-12841	PR:000016008	denotes	TACC3
T2563	12842-12853	SO:0000855	denotes	orthologues
T2564	12873-12887	NCBITaxon:8355	denotes	Xenopus laevis
T2565	12915-12920	PR:000016008	denotes	TACC3
T2566	12934-12949	NCBITaxon:10116	denotes	Rattus norvegus
T2567	12951-12964	NCBITaxon:9031	denotes	Gallus gallus
T2568	12966-12985	NCBITaxon:8364	denotes	Silurana tropicalis
T2569	12987-12998	NCBITaxon:7955	denotes	Danio rerio
T2570	13003-13014	NCBITaxon:31033	denotes	T. rubripes
T3321	13181-13186	PR:000001856	denotes	RHAMM
T3322	13187-13191	SO:0000704	denotes	gene
T3323	13216-13227	SO:0001080	denotes	coiled coil
T3324	13228-13232	SO:0000704	denotes	gene
T3325	13240-13245	NCBITaxon:9606	denotes	Human
T3326	13246-13251	PR:000001856	denotes	RHAMM
T3327	13416-13422	NCBITaxon:9606	denotes	humans
T3328	13473-13484	SO:0001080	denotes	coiled coil
T3329	13485-13491	SO:0000417	denotes	domain
T3330	13504-13510	SO:0000417	denotes	domain
T3331	13551-13556	PR:000001856	denotes	RHAMM
T3332	13572-13582	GO:0005813	denotes	centrosome
T3333	13596-13601	PR:000001856	denotes	RHAMM
T3334	13774-13784	NCBITaxon:7742	denotes	vertebrate
T3335	13785-13791	SO:0001026	denotes	genome
T3336	13822-13827	PR:000001856	denotes	RHAMM
T3337	13828-13839	SO:0000855	denotes	orthologues
T3338	13852-13857	SO:0000704	denotes	genes
T3339	13861-13870	NCBITaxon:33208	denotes	metazoans
T3340	13913-13924	SO:0001080	denotes	coiled coil
T3341	13981-13986	PR:000001856	denotes	RHAMM
T3342	13987-13991	SO:0000704	denotes	gene
T3343	13999-14012	NCBITaxon:33511	denotes	deuterostomes
T3344	14035-14042	SO:0001026	denotes	genomic
T3345	14077-14092	NCBITaxon:7719	denotes	C. intestinalis
T3346	14097-14102	PR:000001856	denotes	RHAMM
T3347	14103-14107	SO:0000704	denotes	gene
T3348	14126-14133	NCBITaxon:6960	denotes	insects
T3349	14137-14146	NCBITaxon:6231	denotes	nematodes
T3350	14172-14177	PR:000001856	denotes	RHAMM
T3351	14183-14188	SO:0000704	denotes	genes
T3352	14208-14218	NCBITaxon:33317	denotes	protostome
T3353	14219-14231	NCBITaxon:33511	denotes	deuterostome
T3354	14268-14281	NCBITaxon:7586	denotes	echinodermata
T3355	14282-14293	NCBITaxon:7712	denotes	urochordate
T3356	14370-14381	SO:0001080	denotes	coiled coil
T3357	14419-14424	PR:000001856	denotes	RHAMM
T3358	14449-14455	SO:0000417	denotes	domain
T3359	14511-14522	SO:0001080	denotes	coiled coil
T3360	14589-14593	SO:0000704	denotes	gene
T3806	14831-14835	SO:0000704	denotes	gene
T3807	14846-14852	NCBITaxon:9606	denotes	humans
T3808	14854-14859	NCBITaxon:10088	denotes	mouse
T3809	14868-14876	NCBITaxon:6656	denotes	arthopod
T3810	14877-14892	NCBITaxon:7227	denotes	D. melanogaster
T3811	14927-14937	_FRAGMENT	denotes	paralogous
T3812	14950-14958	SO:0000854	denotes	segments
T3813	14973-14982	NCBITaxon:1	denotes	organisms
T3814	15130-15140	NCBITaxon:7742	denotes	vertebrate
T3815	15201-15206	NCBITaxon:9606	denotes	human
T3816	15236-15241	NCBITaxon:9606	denotes	human
T3817	15384-15388	SO:0000704	denotes	gene
T3818	15482-15492	_FRAGMENT	denotes	paralogous
T3819	15505-15513	SO:0000854	denotes	segments
T3820	15609-15613	SO:0000704	denotes	gene
T3821	15617-15628	NCBITaxon:7742	denotes	vertebrates
T3822	15676-15681	PR:000001451	denotes	FGFR4
T3823	15739-15744	PR:000001856	denotes	RHAMM
T3824	15745-15749	SO:0000704	denotes	gene
T3825	15787-15792	NCBITaxon:9606	denotes	Human
T3826	15793-15798	PR:000001856	denotes	RHAMM
T3827	15846-15850	PR:000008212	denotes	GPX3
T3828	15855-15860	PR:000011245	denotes	NKX2E
T3829	15898-15903	SO:0000704	denotes	genes
T3830	15907-15912	NCBITaxon:9606	denotes	human
T3831	15935-15945	SO:0000859	denotes	paralogous
T3832	16033-16038	NCBITaxon:10088	denotes	mouse
T3833	16043-16046	NCBITaxon:10114	denotes	rat
T3834	16097-16102	SO:0000704	denotes	genes
T3835	16145-16152	NCBITaxon:9443	denotes	primate
T3836	16153-16159	NCBITaxon:9989	denotes	rodent
T3837	16870-16874	SO:0000704	denotes	gene
T3838	16924-16928	SO:0000704	denotes	gene
T3839	16929-16939	GO:0065007	denotes	regulation
T3840	16991-17010	SO:0000854	denotes	paralogous segments
T3841	17028-17034	SO:0001026	denotes	genome
T3842	17042-17050	NCBITaxon:7712	denotes	tunicate
T3843	17051-17066	NCBITaxon:7719	denotes	C. intestinalis
T3844	17105-17115	NCBITaxon:7742	denotes	vertebrate
T3845	17116-17122	SO:0001026	denotes	genome
T3846	17142-17153	NCBITaxon:31033	denotes	T. rubripes
T3847	17209-17215	SO:0001026	denotes	genome
T3848	17219-17230	NCBITaxon:31033	denotes	T. rubripes
T3849	17278-17288	SO:0000859	denotes	paralogous
T3850	17314-17325	NCBITaxon:7742	denotes	vertebrates
T3851	17354-17365	SO:0000855	denotes	orthologues
T3852	17369-17375	PR:000008258	denotes	GPRK2L
T3853	17380-17385	PR:000013947	denotes	RGS12
T3854	17399-17410	NCBITaxon:31033	denotes	T. rubripes
T3855	17411-17419	SO:0001248	denotes	scaffold
T3856	17481-17486	NCBITaxon:9606	denotes	human
T3857	17497-17508	NCBITaxon:31033	denotes	T. rubripes
T3858	17509-17520	SO:0000855	denotes	orthologues
T3859	17524-17529	PR:000001450	denotes	FGFR3
T3864	17673-17678	SO:0000704	denotes	genes
T3865	17746-17751	PR:000016008	denotes	TACC3
T3866	17756-17761	PR:000007506	denotes	FGFRL
T3867	17785-17794	SO:0001248	denotes	scaffolds
T3868	17854-17858	SO:0000704	denotes	gene
T3869	17893-17898	PR:000008260	denotes	GPRK6
T3870	17902-17907	NCBITaxon:9606	denotes	human
T3871	17950-17960	NCBITaxon:31031	denotes	pufferfish
T3872	17971-17982	NCBITaxon:31033	denotes	T. rubripes
T3873	17983-17994	SO:0000855	denotes	orthologues
T3874	17998-18002	PR:000011441	denotes	NSD1
T3875	18004-18009	PR:000001451	denotes	FGFR4
T3876	18025-18029	SO:0000704	denotes	gene
T3877	18041-18049	SO:0001248	denotes	scaffold
T3878	18110-18114	SO:0000704	denotes	gene
T3879	18140-18144	SO:0000704	denotes	gene
T3880	18259-18264	PR:000016006	denotes	TACC1
T3881	18273-18278	SO:0000704	denotes	genes
T3882	18286-18296	NCBITaxon:31031	denotes	pufferfish
T3883	18332-18340	SO:0001248	denotes	scaffold
T3884	18391-18402	SO:0000855	denotes	orthologues
T3885	18414-18419	SO:0000704	denotes	genes
T3886	18431-18436	NCBITaxon:9606	denotes	human
T3887	18468-18476	SO:0001248	denotes	scaffold
T3888	18509-18514	PR:000016006	denotes	TACC1
T3889	18561-18572	NCBITaxon:7742	denotes	vertebrates
T3890	18606-18610	SO:0000704	denotes	gene
T3891	18636-18644	SO:0001248	denotes	scaffold
T3892	18673-18681	SO:0001248	denotes	scaffold
T3893	18700-18711	NCBITaxon:31033	denotes	T. rubripes
T3894	18712-18723	SO:0000855	denotes	orthologues
T3895	18727-18731	PR:000010686	denotes	MSX1
T3896	18733-18738	PR:000015790	denotes	STX18
T3897	18756-18770	SO:0000996	denotes	predicted gene
T3898	18812-18820	SO:0000857	denotes	homology
T3899	18824-18828	PR:000009884	denotes	LOXL
T3900	18830-18833	PR:000007232	denotes	EVC
T3901	18872-18880	SO:0001248	denotes	scaffold
T3902	18893-18898	SO:0000704	denotes	genes
T3903	18923-18928	NCBITaxon:9606	denotes	human
T3904	18980-18985	PR:000016008	denotes	TACC3
T3905	18990-18995	PR:000016007	denotes	TACC2
T3906	19055-19062	SO:0001026	denotes	genomic
T3907	19132-19142	_FRAGMENT	denotes	paralogous
T3908	19155-19162	SO:0000854	denotes	segment
T3909	19174-19184	SO:0000859	denotes	paralogous
T3910	19240-19245	SO:0000704	denotes	genes
T3911	19278-19285	SO:0001026	denotes	genomic
T3912	19286-19292	SO:0000149	denotes	contig
T3913	19374-19384	_FRAGMENT	denotes	paralogous
T3914	19397-19405	SO:0000854	denotes	segments
T3915	19422-19433	NCBITaxon:7742	denotes	vertebrates
T3916	19452-19458	SO:0001026	denotes	genome
T3917	19466-19477	NCBITaxon:7712	denotes	urochordate
T3918	19478-19493	NCBITaxon:7719	denotes	C. intestinalis
T3919	19518-19529	SO:0000855	denotes	orthologues
T3920	19543-19548	PR:000030426	denotes	WHSC1
T3921	19550-19568	PR:000005841	denotes	carboxypeptidase Z
T3922	19620-19635	NCBITaxon:7719	denotes	C. intestinalis
T3923	19636-19642	SO:0001026	denotes	genome
T3924	19651-19656	NCBITaxon:9606	denotes	human
T3925	19657-19668	SO:0000855	denotes	orthologues
T3926	19693-19712	SO:0000854	denotes	paralogous segments
T3927	19816-19821	SO:0000704	denotes	genes
T3928	19831-19841	NCBITaxon:7742	denotes	vertebrate
T3929	19842-19861	SO:0000854	denotes	paralogous segments
T3930	19894-19899	PR:000001856	denotes	RHAMM
T3931	19900-19905	SO:0000704	denotes	genes
T3932	19909-19924	NCBITaxon:7719	denotes	C. intestinalis
T3933	19975-19994	SO:0000854	denotes	paralogous segments
T3934	20022-20027	SO:0000704	denotes	genes
T3935	20125-20134	NCBITaxon:7712	denotes	tunicates
T3936	20179-20190	NCBITaxon:31033	denotes	T. rubripes
T3937	20191-20197	SO:0001026	denotes	genome
T3938	20328-20333	PR:000001450	denotes	FGFR3
T3939	20368-20372	SO:0000704	denotes	gene
T3940	20389-20393	SO:0000704	denotes	gene
T3941	20417-20427	NCBITaxon:7742	denotes	vertebrate
T3942	20470-20482	NCBITaxon:61463	denotes	Gnanthostome
T3943	20557-20575	SO:0000854	denotes	paralogous segment
T3944	20609-20618	NCBITaxon:7737	denotes	amphioxus
T3945	20623-20630	NCBITaxon:7745	denotes	lamprey
T3946	20631-20638	SO:0001026	denotes	genomes
T3947	20665-20669	SO:0000704	denotes	gene
T3948	20741-20746	SO:0000704	denotes	genes
T5266	21944-21951	SO:0001026	denotes	genomic
T5267	21985-21992	SO:0001026	denotes	genomic
T5268	22028-22039	SO:0000858	denotes	orthologous
T5269	22045-22050	SO:0000704	denotes	genes
T5270	22054-22059	NCBITaxon:9606	denotes	human
T5271	22061-22066	NCBITaxon:10088	denotes	mouse
T5272	22068-22071	NCBITaxon:10114	denotes	rat
T5273	22073-22083	NCBITaxon:31031	denotes	pufferfish
T5274	22085-22100	NCBITaxon:7719	denotes	C. intestinalis
T5275	22102-22117	NCBITaxon:7227	denotes	D. melanogaster
T5276	22122-22132	NCBITaxon:6239	denotes	C. elegans
T5277	22200-22207	SO:0001026	denotes	genomic
T5278	22231-22235	SO:0000704	denotes	gene
T5279	22256-22259	NCBITaxon:10114	denotes	rat
T5280	22264-22274	NCBITaxon:31031	denotes	pufferfish
T5281	22276-22281	SO:0000147	denotes	exons
T5282	22337-22347	GO:0006412	denotes	translated
T5283	22378-22383	NCBITaxon:10088	denotes	mouse
T5284	22388-22393	NCBITaxon:9606	denotes	human
T5285	22448-22459	NCBITaxon:31033	denotes	T. rubripes
T5286	22461-22468	SO:0001026	denotes	genomic
T5287	22495-22500	CHEBI:15377	denotes	water
T5288	22501-22511	NCBITaxon:31031	denotes	pufferfish
T5289	22513-22535	NCBITaxon:99883	denotes	Tetraodon nigroviridis
T5290	22590-22595	SO:0000147	denotes	exons
T5291	22631-22636	SO:0000704	denotes	genes
T5292	22729-22735	SO:0000417	denotes	domain
T5293	22807-22817	NCBITaxon:6239	denotes	C. elegans
T5294	22919-22924	SO:0000147	denotes	exons
T5295	22932-22936	SO:0000704	denotes	gene
T5296	22952-22961	NCBITaxon:1	denotes	organisms
T5297	22963-22978	NCBITaxon:7227	denotes	D. melanogaster
T5298	22988-23001	NCBITaxon:33511	denotes	deuterostomes
T5299	23002-23017	NCBITaxon:7719	denotes	C. intestinalis
T5300	23021-23026	NCBITaxon:9606	denotes	human
T5301	23070-23075	SO:0000147	denotes	exons
T5302	23083-23087	SO:0000704	denotes	gene
T5303	23097-23112	NCBITaxon:7227	denotes	D. melanogaster
T5304	23127-23139	NCBITaxon:33511	denotes	deuterostome
T5305	23140-23145	SO:0000704	denotes	genes
T5306	23168-23174	SO:0000417	denotes	domain
T5307	23228-23236	SO:0000857	denotes	homology
T5308	23271-23275	SO:0000704	denotes	gene
T5309	23295-23299	SO:0000147	denotes	exon
T5310	23351-23362	SO:0000855	denotes	orthologues
T5311	23412-23417	PR:000016008	denotes	TACC3
T5312	23418-23423	SO:0000704	denotes	genes
T5313	23431-23442	NCBITaxon:7742	denotes	vertebrates
T5314	23459-23472	NCBITaxon:33511	denotes	deuterostomes
T5315	23479-23483	SO:0000147	denotes	exon
T5316	23531-23537	NCBITaxon:39107	denotes	murine
T5317	23538-23545	PR:000016008	denotes	TACC3's
T5318	23549-23555	NCBITaxon:9989	denotes	rodent
T5319	23632-23668	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T5320	23640-23660	GO:0006338	denotes	chromatin remodeling
T5321	23679-23684	PR:000017527	denotes	GAS41
T5322	23701-23711	NCBITaxon:7742	denotes	vertebrate
T5323	23731-23736	PR:000016008	denotes	TACC3
T5324	23737-23748	SO:0000855	denotes	orthologues
T5325	23846-23849	NCBITaxon:10114	denotes	rat
T5326	23850-23855	PR:000016008	denotes	TACC3
T5327	23891-23902	NCBITaxon:7955	denotes	Danio rerio
T5328	23968-23975	SO:0001026	denotes	genomic
T5329	23993-23998	PR:000016008	denotes	TACC3
T5330	23999-24010	SO:0000855	denotes	orthologues
T5331	24012-24017	PR:000016008	denotes	TACC3
T5332	24122-24127	SO:0000147	denotes	exons
T5333	24144-24154	NCBITaxon:7742	denotes	vertebrate
T5334	24155-24160	PR:000016008	denotes	TACC3
T5335	24161-24165	SO:0000704	denotes	gene
T5336	24186-24192	SO:0000417	denotes	domain
T5337	24226-24231	SO:0000147	denotes	exons
T5338	24352-24357	PR:000016008	denotes	TACC3
T5339	24370-24375	NCBITaxon:9606	denotes	human
T5340	24380-24385	NCBITaxon:10088	denotes	mouse
T5341	24469-24480	SO:0000855	denotes	orthologues
T5342	24580-24584	SO:0000147	denotes	exon
T5343	24588-24593	NCBITaxon:9606	denotes	human
T5344	24602-24612	NCBITaxon:31031	denotes	pufferfish
T5345	24636-24643	NCBITaxon:9989	denotes	rodents
T5346	24756-24760	SO:0000147	denotes	exon
T5347	24768-24773	NCBITaxon:10088	denotes	mouse
T5348	24778-24781	NCBITaxon:10114	denotes	rat
T5349	24782-24787	PR:000016008	denotes	TACC3
T5350	24788-24793	SO:0000704	denotes	genes
T5351	24847-24852	NCBITaxon:10088	denotes	mouse
T5352	24853-24858	PR:000016008	denotes	TACC3
T5353	24859-24865	GO:0008380	denotes	splice
T5354	24969-24973	SO:0000147	denotes	exon
T5355	25297-25303	NCBITaxon:9986	denotes	rabbit
T5356	25366-25372	NCBITaxon:9989	denotes	rodent
T5357	25373-25378	PR:000016008	denotes	TACC3
T5358	25445-25454	NCBITaxon:8292	denotes	amphibian
T5359	25455-25462	NCBITaxon:8353	denotes	Xenopus
T5360	25463-25468	PR:000016008	denotes	TACC3
T6239	25483-25503	GO:0000380	denotes	Alternative splicing
T6240	25507-25517	NCBITaxon:7742	denotes	vertebrate
T6241	25523-25528	SO:0000704	denotes	genes
T6242	25537-25541	SO:0000147	denotes	exon
T6243	25596-25600	SO:0000704	denotes	gene
T6244	25654-25660	UBERON:0000479	denotes	tissue
T6245	25670-25690	GO:0000380	denotes	alternative splicing
T6246	25696-25700	SO:0000704	denotes	gene
T6247	25757-25761	SO:0000704	denotes	gene
T6248	25773-25787	_FRAGMENT	denotes	development of
T6249	25791-25799	GO:0044767	denotes	organism
T6250	25791-25799	NCBITaxon:1	denotes	organism
T6251	25813-25833	GO:0000380	denotes	alternative splicing
T6252	25837-25842	PR:000016008	denotes	TACC3
T6253	25890-25896	UBERON:0000479	denotes	tissue
T6254	25906-25914	GO:0008380	denotes	splicing
T6255	25934-25939	PR:000016006	denotes	TACC1
T6256	25944-25949	PR:000016007	denotes	TACC2
T6257	25950-25955	SO:0000704	denotes	genes
T6258	25972-25977	PR:000016007	denotes	TACC2
T6259	26006-26010	SO:0000147	denotes	exon
T6260	26062-26068	GO:0008380	denotes	splice
T6261	26085-26095	NCBITaxon:7742	denotes	vertebrate
T6262	26096-26101	PR:000016007	denotes	TACC2
T6263	26102-26107	SO:0000704	denotes	genes
T6264	26117-26137	GO:0000380	denotes	alternative splicing
T6265	26146-26150	SO:0000147	denotes	exon
T6266	26206-26211	PR:000016007	denotes	TACC2
T6267	26212-26220	SO:0001060	denotes	isoforms
T6268	26289-26294	PR:000016007	denotes	TACC2
T6269	26333-26338	PR:000016006	denotes	TACC1
T6270	26391-26398	SO:0001060	denotes	isoform
T6271	26419-26439	GO:0000380	denotes	Alternative splicing
T6272	26468-26476	SO:0000167	denotes	promoter
T6273	26514-26519	NCBITaxon:9606	denotes	human
T6274	26520-26525	PR:000016006	denotes	TACC1
T6275	26526-26530	SO:0000704	denotes	gene
T6276	26603-26608	PR:000016006	denotes	TACC1
T6277	26609-26617	SO:0001060	denotes	isoforms
T6278	26635-26655	GO:0000380	denotes	alternative splicing
T6279	26659-26664	SO:0000147	denotes	exons
T6280	26705-26713	SO:0001060	denotes	isoforms
T6281	26796-26808	SO:0000409	denotes	binding site
T6282	26813-26817	PR:000009965	denotes	LSm7
T6283	26856-26863	GO:0005634	denotes	nuclear
T6284	26856-26884	SO:0001528	denotes	nuclear localization signals
T6285	26889-26901	SO:0000409	denotes	binding site
T6286	26906-26911	PR:000017527	denotes	GAS41
T6287	26921-26931	PR:000029784	denotes	PCTAIRE2BP
T6288	26938-26946	SO:0001060	denotes	isoforms
T6289	26969-26977	SO:0001060	denotes	isoforms
T6290	27018-27027	GO:0005737	denotes	cytoplasm
T6291	27062-27070	SO:0001060	denotes	isoforms
T6292	27122-27130	GO:0000785	denotes	chomatin
T6293	27122-27141	GO:0006338	denotes	chomatin remodeling
T6294	27149-27163	GO:0006396	denotes	RNA processing
T6295	27181-27188	GO:0005634	denotes	nucleus
T6296	27225-27230	PR:000016006	denotes	TACC1
T6297	27231-27239	SO:0001060	denotes	isoforms
T6298	27281-27289	_FRAGMENT	denotes	cellular
T6299	27294-27304	GO:0044237	denotes	metabolism
T6300	27290-27304	GO:0016070	denotes	RNA metabolism
T6301	27384-27392	SO:0001060	denotes	isoforms
T6302	27436-27450	UBERON:0001199	denotes	gastric mucosa
T6914	28736-28743	SO:0001026	denotes	genomic
T6915	28917-28923	SO:0000417	denotes	domain
T6916	28995-29002	GO:0007067	denotes	mitotic
T6917	28995-29010	GO:0072686	denotes	mitotic spindle
T6918	29015-29026	GO:0005813	denotes	centrosomal
T6919	29154-29163	SO:0000853	denotes	homologue
T6920	29174-29180	PR:P39723	denotes	spc-72
T6921	29198-29203	NCBITaxon:9606	denotes	human
T6922	29309-29315	SO:0000417	denotes	domain
T6923	29326-29337	GO:0005874	denotes	microtubule
T6924	29338-29349	GO:0005813	denotes	centrosomal
T6925	29366-29370	PR:P46675	denotes	stu2
T6926	29371-29375	PR:Q9VEZ3	denotes	msps
T6927	29376-29382	PR:000005512	denotes	ch-TOG
T6928	29416-29430	PR:000035365	denotes	Aurora kinases
T6929	29511-29516	PR:P39723	denotes	spc72
T6930	29529-29534	PR:000016008	denotes	TACC3
T6931	29551-29561	GO:0005813	denotes	centrosome
T6932	29619-29629	GO:0005813	denotes	centrosome
T6933	29634-29641	GO:0007067	denotes	mitotic
T6934	29634-29649	GO:0072686	denotes	mitotic spindle
T6935	29758-29763	NCBITaxon:9606	denotes	human
T6936	29828-29842	PR:000035365	denotes	Aurora kinases
T6937	29858-29863	PR:000016006	denotes	TACC1
T6938	29868-29873	PR:000016008	denotes	TACC3
T6939	29888-29903	PR:000004515	denotes	Aurora A kinase
T6940	29913-29918	PR:000016007	denotes	TACC2
T6941	29934-29949	PR:000004518	denotes	Aurora C kinase
T6942	30041-30049	NCBITaxon:7711	denotes	chordate
T6943	30083-30093	NCBITaxon:7742	denotes	vertebrate
T6944	30099-30104	SO:0000704	denotes	genes
T6945	30130-30140	NCBITaxon:7742	denotes	vertebrate
T6946	30162-30172	GO:0051325	denotes	interphase
T6947	30173-30180	GO:0005634	denotes	nucleus
T6948	30271-30281	GO:0005813	denotes	centrosome
T6949	30286-30297	GO:0005874	denotes	microtubule
T6950	30286-30306	GO:0000226	denotes	microtubule dynamics
T6951	30358-30369	NCBITaxon:33317	denotes	protostomes
T6952	30374-30387	NCBITaxon:33511	denotes	deuterostomes
T6953	30446-30451	SO:0000704	denotes	genes
T6954	30472-30477	SO:0000147	denotes	exons
T6955	30538-30548	NCBITaxon:6239	denotes	C. elegans
T6956	30553-30568	NCBITaxon:7227	denotes	D. melanogaster
T6957	30700-30710	NCBITaxon:6239	denotes	C. elegans
T6958	30700-30717	PR:Q27365	denotes	C. elegans lin15A
T6959	30700-30710	_FRAGMENT	denotes	C. elegans
T6960	30719-30724	PR:P34427	denotes	lin36
T6961	30729-30734	PR:000009822	denotes	lin37
T6984	31356-31373	GO:0006281	denotes	DNA damage repair
T6985	31455-31465	GO:0006281	denotes	DNA repair
T6986	31506-31516	NCBITaxon:6239	denotes	C. elegans
T6987	31517-31522	PR:000004642	denotes	BARD1
T6988	31523-31533	SO:0000855	denotes	orthologue
T6989	31623-31632	NCBITaxon:1	denotes	organisms
T6990	31771-31775	PR:P46675	denotes	stu2
T6991	31776-31780	PR:Q9VEZ3	denotes	msps
T6992	31781-31787	PR:000005512	denotes	ch-TOG
T6993	32958-32964	SO:0000417	denotes	domain
T6994	33032-33042	NCBITaxon:6239	denotes	C. elegans
T6995	33047-33062	NCBITaxon:7227	denotes	D. melanogaster
T6996	33091-33098	NCBITaxon:33208	denotes	animals
T6997	33207-33217	NCBITaxon:7742	denotes	vertebrate
T6998	33267-33277	NCBITaxon:6239	denotes	C. elegans
T6999	33296-33302	PR:Q27365	denotes	lin15A
T7000	33304-33309	PR:P34427	denotes	lin36
T7001	33314-33319	PR:000009822	denotes	lin37
T7002	33352-33362	SO:0000853	denotes	homologues
T7003	33366-33377	NCBITaxon:7742	denotes	vertebrates
T7004	33381-33391	NCBITaxon:7215	denotes	Drosophila
T7005	33432-33438	SO:0000417	denotes	domain
T7006	33442-33447	PR:P34427	denotes	lin36
T7007	33635-33640	PR:000016057	denotes	TDP43
T7008	33682-33692	GO:0065007	denotes	regulation
T7009	33697-33705	GO:0008380	denotes	splicing
T7010	33746-33751	NCBITaxon:9606	denotes	human
T7011	33752-33761	SO:0000853	denotes	homologue
T7012	33820-33825	NCBITaxon:9606	denotes	human
T7013	33911-33916	SO:0001980	denotes	G-box
T8091	34004-34014	NCBITaxon:7742	denotes	vertebrate
T8092	34058-34068	NCBITaxon:7742	denotes	vertebrate
T8093	34255-34265	NCBITaxon:7742	denotes	vertebrate
T8094	34368-34378	GO:0005813	denotes	centrosome
T8095	34379-34386	GO:0007067	denotes	mitotic
T8096	34379-34394	GO:0072686	denotes	mitotic spindle
T8097	34433-34437	SO:0000704	denotes	gene
T8098	34438-34448	GO:0065007	denotes	regulation
T8099	34502-34516	GO:0006396	denotes	RNA processing
T8100	34521-34532	GO:0006412	denotes	translation
T8101	34688-34703	GO:0043234	denotes	protein complex
T8102	34780-34790	GO:0005813	denotes	centrosome
T8103	34811-34826	GO:0072686	denotes	mitotic spindle
T8104	34811-34835	GO:0090307	denotes	mitotic spindle assembly
T8105	34934-34944	NCBITaxon:7742	denotes	vertebrate
T8106	34945-34950	PR:000016008	denotes	TACC3
T8107	35055-35062	GO:0007067	denotes	mitosis
T8108	35097-35112	PR:000004515	denotes	Aurora Kinase A
T8109	35154-35159	NCBITaxon:9606	denotes	human
T8110	35249-35255	SO:0000417	denotes	domain
T8111	35263-35273	NCBITaxon:7742	denotes	vertebrate
T8112	35274-35285	SO:0000855	denotes	orthologues
T8113	35301-35306	PR:000016008	denotes	TACC3
T8114	35365-35372	NCBITaxon:species	denotes	species
T8115	35410-35419	NCBITaxon:8355	denotes	X. laevis
T8116	35455-35471	_FRAGMENT	denotes	binding site for
T8117	35482-35489	SO:0000410	denotes	protein
T8118	35476-35481	PR:000006990	denotes	eIF4E
T8119	35530-35540	_FRAGMENT	denotes	control of
T8120	35561-35572	GO:0006417	denotes	translation
T8121	35541-35556	GO:0043631	denotes	polyadenylation
T8122	35580-35587	NCBITaxon:8353	denotes	Xenopus
T8123	35588-35594	CL:0000023	denotes	oocyte
T8124	35717-35727	NCBITaxon:7742	denotes	vertebrate
T8125	35728-35733	PR:000016008	denotes	TACC3
T8126	35761-35766	PR:000006990	denotes	eIF4E
T8127	35767-35771	PR:000005805	denotes	CPEB
T8128	35772-35779	GO:0032991	denotes	complex
T8129	35785-35790	NCBITaxon:9606	denotes	human
T8130	35798-35805	SO:0001060	denotes	isoform
T8131	35837-35842	PR:000006990	denotes	eIF4E
T8132	35843-35847	PR:000005805	denotes	CPEB
T8133	35848-35855	GO:0032991	denotes	complex
T8134	35871-35876	PR:000016006	denotes	TACC1
T8135	35877-35885	SO:0001060	denotes	isoforms
T8136	35977-35989	GO:0008380	denotes	RNA splicing
T8137	35977-35980	_FRAGMENT	denotes	RNA
T8138	35994-36003	GO:0050658	denotes	transport
T8139	36186-36191	NCBITaxon:9606	denotes	human
T8140	36248-36253	UBERON:0000955	denotes	brain
T8141	36318-36325	PR:000043452	denotes	histone
T8142	36318-36325	CHEBI:15358	denotes	histone
T8143	36344-36351	PR:Q92830	denotes	hGCN5L2
T8144	36384-36391	SO:0001060	denotes	isoform
T8145	36395-36403	CHEBI:26537	denotes	retinoid
T8146	36395-36416	PR:000014373	denotes	retinoid-X receptor β
T8147	36459-36465	SO:0000417	denotes	domain
T8148	36469-36474	PR:000016007	denotes	TACC2
T8149	36577-36581	PR:000014373	denotes	RXRβ
T8150	36616-36623	GO:0005634	denotes	nuclear
T8151	36642-36648	PR:Q965W2	denotes	nhr-86
T8152	36655-36665	NCBITaxon:6239	denotes	C. elegans
T8153	36714-36719	PR:P34427	denotes	lin36
T8154	36756-36766	NCBITaxon:33317	denotes	protostome
T8155	36866-36875	NCBITaxon:1	denotes	organisms
T8156	37065-37072	SO:0000417	denotes	domains
T8157	37096-37104	NCBITaxon:7711	denotes	chordate
T8158	37165-37175	NCBITaxon:7742	denotes	vertebrate
T8159	37271-37275	PR:000004303	denotes	ARNT
T8160	37333-37345	NCBITaxon:33511	denotes	deuterostome
T8161	37381-37386	PR:000017527	denotes	GAS41
T8162	37424-37429	NCBITaxon:9606	denotes	human
T8163	37430-37466	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T8164	37438-37458	GO:0006338	denotes	chromatin remodeling
T8165	37495-37510	NCBITaxon:7227	denotes	D. melanogaster
T8166	37511-37520	SO:0000853	denotes	homologue
T8167	37524-37529	PR:000017527	denotes	GAS41
T8168	37688-37701	SO:0000657	denotes	repeat region
T8169	37709-37719	NCBITaxon:7215	denotes	Drosophila
T8170	37765-37775	NCBITaxon:7742	denotes	vertebrate
T8171	37855-37865	GO:0065007	denotes	regulatory
T8172	37866-37875	GO:0032991	denotes	complexes
T8173	37886-37894	GO:0030674	denotes	bridging
T8174	37989-37995	SO:0000417	denotes	domain
T8175	38052-38063	NCBITaxon:33317	denotes	protostomes
T8176	38068-38081	NCBITaxon:33511	denotes	deuterostomes
T8177	38131-38139	GO:0030674	denotes	bridging
T8178	38162-38168	PR:Q27365	denotes	lin15A
T8179	38170-38175	PR:P34427	denotes	lin36
T8180	38179-38184	PR:000009822	denotes	lin37
T8181	38224-38230	PR:Q27365	denotes	lin15A
T8182	38232-38237	PR:P34427	denotes	lin36
T8183	38242-38247	PR:000009822	denotes	lin37
T8184	38248-38258	SO:0000853	denotes	homologues
T8185	38269-38278	NCBITaxon:1	denotes	organisms
T8186	38362-38369	GO:0032991	denotes	complex
T8187	38401-38407	SO:0001026	denotes	genome
T9362	41543-41547	SO:0000147	denotes	exon
T9289	38886-38890	SO:0000704	denotes	gene
T9290	38929-38933	SO:0000704	denotes	gene
T9291	39025-39029	SO:0000704	denotes	gene
T9292	39087-39096	SO:0000853	denotes	homologue
T9293	39107-39112	PR:P39723	denotes	spc72
T9294	39137-39148	GO:0005813	denotes	centrosomal
T9295	39149-39156	GO:0007067	denotes	mitotic
T9296	39149-39164	GO:0072686	denotes	mitotic spindle
T9297	39252-39263	NCBITaxon:33317	denotes	protostomes
T9298	39268-39281	NCBITaxon:33511	denotes	deuterostomes
T9299	39323-39332	NCBITaxon:1	denotes	organisms
T9300	39357-39365	GO:0030674	denotes	bridging
T9301	39416-39433	GO:0043234	denotes	protein complexes
T9302	39446-39463	GO:0006281	denotes	DNA damage repair
T9303	39473-39484	GO:0006412	denotes	translation
T9304	39486-39500	GO:0006396	denotes	RNA processing
T9305	39596-39603	SO:0000417	denotes	domains
T9306	39627-39635	NCBITaxon:7711	denotes	chordate
T9307	39656-39664	NCBITaxon:7711	denotes	chordate
T9308	39769-39778	GO:0032991	denotes	complexes
T9309	39806-39813	GO:0005634	denotes	nuclear
T9310	39833-39838	PR:000017527	denotes	GAS41
T9311	39938-39947	GO:0032991	denotes	complexes
T9312	39990-40000	NCBITaxon:7742	denotes	vertebrate
T9313	40015-40020	NCBITaxon:10088	denotes	mouse
T9314	40021-40026	PR:000016008	denotes	TACC3
T9315	40072-40076	PR:000004303	denotes	ARNT
T9316	40126-40151	CHEBI:33848	denotes	polyaromatic hydrocarbons
T9317	40157-40162	NCBITaxon:10088	denotes	Mouse
T9318	40163-40168	PR:000016008	denotes	TACC3
T9319	40234-40239	PR:000002091	denotes	STAT5
T9320	40282-40287	PR:000016007	denotes	TACC2
T9321	40292-40297	PR:000016008	denotes	TACC3
T9322	40310-40317	GO:0005634	denotes	nuclear
T9323	40318-40325	PR:000043452	denotes	histone
T9324	40318-40325	CHEBI:15358	denotes	histone
T9325	40434-40443	GO:0000785	denotes	chromatin
T9326	40434-40454	GO:0006338	denotes	chromatin remodeling
T9327	40490-40495	NCBITaxon:9606	denotes	human
T9328	40541-40548	PR:000043452	denotes	histone
T9329	40541-40548	CHEBI:15358	denotes	histone
T9330	40567-40571	PR:000012332	denotes	pCAF
T9331	40586-40591	PR:000016006	denotes	TACC1
T9332	40592-40600	SO:0001060	denotes	isoforms
T9333	40601-40610	GO:0010467	denotes	expressed
T9334	40614-40619	NCBITaxon:9606	denotes	human
T9335	40620-40626	UBERON:0000310	denotes	breast
T9336	40666-40673	PR:000043452	denotes	histone
T9337	40666-40673	CHEBI:15358	denotes	histone
T9338	40747-40751	SO:0000147	denotes	Exon
T9339	40765-40770	PR:000016006	denotes	TACC1
T9340	40783-40797	GO:0006396	denotes	RNA processing
T9341	40824-40829	PR:000009965	denotes	LSm-7
T9342	40834-40837	PR:000015348	denotes	SmG
T9343	40850-40870	GO:0000380	denotes	alternative splicing
T9344	40878-40883	PR:000016006	denotes	TACC1
T9345	40884-40888	SO:0000704	denotes	gene
T9346	40915-40920	PR:000016006	denotes	TACC1
T9347	40959-40964	SO:0000147	denotes	exons
T9348	40994-41001	SO:0000417	denotes	domains
T9349	41028-41045	GO:0043234	denotes	protein complexes
T9350	41116-41122	GO:0008380	denotes	splice
T9351	41199-41204	PR:000016006	denotes	TACC1
T9352	41205-41210	PR:000016007	denotes	TACC2
T9353	41329-41334	PR:000016007	denotes	TACC2
T9354	41366-41371	PR:000016008	denotes	TACC3
T9355	41389-41394	PR:000017527	denotes	GAS41
T9356	41396-41400	PR:000015262	denotes	INI1
T9357	41402-41409	PR:000043452	denotes	histone
T9358	41402-41409	CHEBI:15358	denotes	histone
T9359	41470-41474	PR:000014373	denotes	RXRβ
T9360	41506-41512	UBERON:0000479	denotes	tissue
T9361	41522-41530	GO:0008380	denotes	splicing
T9363	41562-41569	SO:0001060	denotes	isoform
T9364	41627-41633	UBERON:0000479	denotes	tissue
T10027	41755-41760	SO:0000704	denotes	genes
T10028	41775-41786	SO:0000858	denotes	orthologous
T10029	41807-41812	PR:000001856	denotes	RHAMM
T10030	41931-41938	SO:0001026	denotes	genomic
T10031	41963-41980	NCBITaxon:31033	denotes	Takifugu rubripes
T10032	41982-41986	SO:0000704	denotes	gene
T10033	42106-42122	SO:0000853	denotes	homology regions
T10034	42182-42187	SO:0000147	denotes	exons
T10035	42204-42209	SO:0000147	denotes	exons
T10036	42265-42275	GO:0006412	denotes	translated
T10037	42306-42311	NCBITaxon:10088	denotes	mouse
T10038	42316-42321	NCBITaxon:9606	denotes	human
T10039	42374-42381	SO:0001026	denotes	genomic
T10040	42408-42413	CHEBI:15377	denotes	water
T10041	42414-42424	NCBITaxon:31031	denotes	pufferfish
T10042	42426-42448	NCBITaxon:99883	denotes	Tetraodon nigroviridis
T10043	42503-42508	SO:0000147	denotes	exons
T10044	42558-42568	NCBITaxon:7742	denotes	vertebrate
T10045	42569-42574	PR:000016008	denotes	TACC3
T10046	42630-42647	NCBITaxon:31033	denotes	Takifugu rubripes
T10047	42648-42653	PR:000016008	denotes	TACC3
T10048	42694-42705	NCBITaxon:7955	denotes	Danio rerio
T10049	42706-42711	PR:000016008	denotes	TACC3
T10050	42820-42830	_FRAGMENT	denotes	paralogous
T10051	42843-42851	SO:0000854	denotes	segments
T10052	42856-42864	SO:0001248	denotes	scaffold
T10053	42944-42949	NCBITaxon:9606	denotes	Human
T10054	42950-42956	SO:0001026	denotes	Genome
T10344	43000-43010	NCBITaxon:7742	denotes	vertebrate
T10345	43026-43032	NCBITaxon:9986	denotes	rabbit
T10346	43033-43038	PR:000016008	denotes	TACC3
T10347	43087-43093	SO:0000112	denotes	primer
T10348	43148-43157	SO:0000993	denotes	consensus
T10349	43158-43164	SO:0000112	denotes	primer
T10350	43214-43224	NCBITaxon:7742	denotes	vertebrate
T10351	43225-43230	PR:000016008	denotes	TACC3
T10352	43303-43308	NCBITaxon:10088	denotes	mouse
T10353	43326-43333	SO:0000112	denotes	primers
T10354	43359-43366	SO:0001026	denotes	genomic
T10355	43416-43426	SO:0000317	denotes	cDNA clone
T10356	43689-43694	PR:000016006	denotes	TACC1
T10357	43695-43701	GO:0000380	denotes	splice
T10358	43716-43731	SO:0000121	denotes	forward primers
T10359	43753-43757	SO:0000147	denotes	exon
T10360	43794-43798	SO:0000147	denotes	Exon
T10361	43838-43842	SO:0000147	denotes	Exon
T10362	43884-43899	SO:0000132	denotes	reverse primers
T10363	43911-43915	SO:0000147	denotes	Exon
T10364	43957-43961	SO:0000147	denotes	Exon
T10365	44003-44007	SO:0000147	denotes	Exon
T10366	44049-44053	SO:0000147	denotes	Exon
T10367	44093-44097	SO:0000147	denotes	Exon
T10368	44139-44145	NCBITaxon:9986	denotes	Rabbit
T10369	44146-44151	UBERON:0000955	denotes	brain
T10370	44152-44159	SO:0000610	denotes	poly A+
T10371	44166-44171	NCBITaxon:10088	denotes	mouse
T10372	44172-44178	UBERON:0000473	denotes	testis
T10373	44183-44188	NCBITaxon:9606	denotes	human
T10374	44189-44194	UBERON:0000955	denotes	brain
T10375	44272-44293	GO:0001171	denotes	Reverse transcription
T10376	44384-44391	SO:0000610	denotes	poly A+
T10377	44442-44454	SO:0000006	denotes	PCR products
T10378	44517-44528	GO:0009294	denotes	transformed
T10379	44558-44565	SO:0000155	denotes	Plasmid
T10380	44566-44573	SO:0000667	denotes	inserts
T10381	44626-44636	CHEBI:33694	denotes	Biopolymer
T10895	44798-44810	NCBITaxon:9606	denotes	Homo sapiens
T10896	44811-44816	PR:000016006	denotes	TACC1
T10897	44823-44830	SO:0001060	denotes	isoform
T10898	44845-44857	NCBITaxon:10090	denotes	Mus musculus
T10899	44858-44863	PR:000016006	denotes	TACC1
T10900	44870-44877	SO:0001060	denotes	isoform
T10901	44892-44904	NCBITaxon:10090	denotes	Mus musculus
T10902	44905-44910	PR:000016006	denotes	TACC1
T10903	44916-44923	SO:0001060	denotes	isoform
T10904	44938-44950	NCBITaxon:10090	denotes	Mus musculus
T10905	44970-44991	NCBITaxon:9986	denotes	Oryctolagus cuniculus
T10906	44992-44997	PR:000016008	denotes	TACC3
T10907	45010-45021	NCBITaxon:7955	denotes	Danio rerio
T10908	45022-45027	PR:000016008	denotes	TACC3
T10909	45125-45140	NCBITaxon:10116	denotes	Rattus norvegus
T10910	45141-45146	PR:000016006	denotes	TACC1
T10911	45152-45159	SO:0001060	denotes	isoform
T10912	45174-45191	NCBITaxon:31033	denotes	Takifugu rubripes
T10913	45220-45237	NCBITaxon:31033	denotes	Takifugu rubripes
T10914	45257-45269	NCBITaxon:10090	denotes	Mus musculus
T10915	45289-45304	NCBITaxon:10116	denotes	Rattus norvegus
T10916	45324-45339	NCBITaxon:10116	denotes	Rattus norvegus
T10917	45359-45376	NCBITaxon:31033	denotes	Takifugu rubripes
T10918	45396-45411	NCBITaxon:10116	denotes	Rattus norvegus
T10919	45412-45417	PR:000016008	denotes	TACC3
T10920	45430-45443	NCBITaxon:9031	denotes	Gallus gallus
T10921	45444-45449	PR:000016008	denotes	TACC3
T10922	45462-45481	NCBITaxon:8364	denotes	Silurana tropicalis
T10923	45482-45487	PR:000016008	denotes	TACC3
T10924	45499-45516	NCBITaxon:31033	denotes	Takifugu rubripes
T10925	45517-45522	PR:000016008	denotes	TACC3
T10926	45535-45552	NCBITaxon:31033	denotes	Takifugu rubripes
T10927	45553-45558	PR:000001856	denotes	RHAMM
T10928	45571-45589	NCBITaxon:7719	denotes	Ciona intestinalis
T10929	45590-45595	PR:000001856	denotes	RHAMM
T10930	45608-45625	NCBITaxon:31033	denotes	Takifugu rubripes
T10931	45646-45663	NCBITaxon:31033	denotes	Takifugu rubripes
T10932	45664-45668	PR:000016579	denotes	TPM1
T10933	45681-45699	NCBITaxon:7719	denotes	Ciona intestinalis
T10934	45700-45705	PR:000009312	denotes	Kif3b
T10935	45718-45736	NCBITaxon:7719	denotes	Ciona intestinalis
T10936	45737-45741	PR:000009289	denotes	klp2
T11298	45847-45858	SO:0001080	denotes	coiled coil
T11299	45859-45866	SO:0000417	denotes	domains
T11300	45955-45960	PR:000001856	denotes	RHAMM
T11301	46006-46017	NCBITaxon:7742	denotes	vertebrates
T11302	46041-46052	SO:0000855	denotes	orthologues
T11303	46062-46073	NCBITaxon:7712	denotes	urochordate
T11304	46074-46092	NCBITaxon:7719	denotes	Ciona intestinalis
T11305	46094-46117	NCBITaxon:7227	denotes	Drosophila melanogaster
T11306	46119-46129	NCBITaxon:6239	denotes	C. elegans
T11307	46134-46158	NCBITaxon:4932	denotes	Saccharomyces cerevisiae
T11308	46261-46268	NCBITaxon:species	denotes	Species
T11309	46299-46301	NCBITaxon:9606	denotes	hs
T11310	46303-46315	NCBITaxon:9606	denotes	Homo sapiens
T11311	46318-46320	NCBITaxon:10090	denotes	mm
T11312	46322-46334	NCBITaxon:10090	denotes	Mus musculus
T11313	46337-46339	NCBITaxon:10116	denotes	rn
T11314	46341-46356	NCBITaxon:10116	denotes	Rattus norvegus
T11315	46359-46361	NCBITaxon:9986	denotes	oc
T11316	46363-46384	NCBITaxon:9986	denotes	Oryctolagus cuniculus
T11317	46387-46389	NCBITaxon:9031	denotes	gg
T11318	46391-46404	NCBITaxon:9031	denotes	Gallus gallus
T11319	46407-46409	NCBITaxon:8355	denotes	xl
T11320	46411-46425	NCBITaxon:8355	denotes	Xenopus laevis
T11321	46428-46430	NCBITaxon:8364	denotes	st
T11322	46432-46451	NCBITaxon:8364	denotes	Silurana tropicalis
T11323	46454-46456	NCBITaxon:31033	denotes	tr
T11324	46458-46475	NCBITaxon:31033	denotes	Takifugu rubripes
T11325	46478-46480	NCBITaxon:7955	denotes	dr
T11326	46482-46493	NCBITaxon:7955	denotes	Danio rerio
T11327	46496-46498	NCBITaxon:7719	denotes	ci
T11328	46500-46518	NCBITaxon:7719	denotes	Ciona intestinalis
T11329	46521-46523	NCBITaxon:7227	denotes	dm
T11330	46525-46540	NCBITaxon:7227	denotes	D. melanogaster
T11331	46543-46545	NCBITaxon:6239	denotes	ce
T11332	46547-46557	NCBITaxon:6239	denotes	C. elegans
T11333	46560-46562	NCBITaxon:4932	denotes	sc
T11334	46564-46588	NCBITaxon:4932	denotes	Saccharomyces cerevisiae
T11335	46711-46719	PR:O75410-1	denotes	hsTACC1A
T11336	46733-46741	PR:O95359-4	denotes	hsTACC2l
T11337	46753-46761	PR:O95359-1	denotes	hsTACC2s
T11338	46774-46781	PR:Q9Y6A5	denotes	hsTACC3
T11339	46795-46802	PR:Q9JJ11	denotes	mmTACC3
T11340	46871-46878	PR:P39723	denotes	scSPC72
T11341	46892-46899	PR:O75330	denotes	hsRHAMM
T11342	46913-46920	PR:Q00547	denotes	mmRHAMM
T11343	46934-46941	PR:P97779	denotes	rnRHAMM
T11344	46955-46962	PR:Q9W3V2	denotes	drRHAMM
T11345	47040-47046	PR:P09493	denotes	hsTPM1
T11346	47060-47066	PR:P58771	denotes	mmTPM1
T11347	47080-47086	PR:P04692	denotes	rnTPM1
T11348	47098-47104	PR:P13104	denotes	drTPM1
T11349	47152-47158	PR:P17536	denotes	scTPM1
T11350	47169-47175	PR:Q9NS87	denotes	hsKLP2
T11351	47188-47195	PR:Q7TSP2	denotes	rnKIF15
T11352	47227-47233	PR:P46863	denotes	dmKLP2
T11353	47267-47274	PR:Q9Y496	denotes	hsKIF3A
T11354	47285-47292	PR:P28741	denotes	mmKIF3A
T11355	47391-47398	PR:O15066	denotes	hsKIF3B
T11356	47412-47419	PR:Q61771	denotes	mmKIF3B
T11357	47454-47461	PR:P46867	denotes	dmKIF3B
T11358	47475-47482	PR:O14782	denotes	hsKIF3C
T11359	47496-47503	PR:O35066	denotes	mmKIF3C
T11360	47517-47524	PR:O55165	denotes	rnKIF3C
T12028	48321-48326	PR:000016007	denotes	TACC2
T12029	48341-48346	PR:000016007	denotes	TACC2
T12030	48379-48385	SO:0000440	denotes	vector
T12031	48451-48456	PR:000016007	denotes	TACC2
T12032	48471-48480	GO:0010467	denotes	expressed
T12033	48484-48491	NCBITaxon:562	denotes	E. coli
T12034	48521-48525	CHEBI:61448	denotes	IPTG
T12035	48614-48618	CHEBI:9754	denotes	Tris
T12036	48619-48622	CHEBI:17883	denotes	HCl
T12037	48638-48642	CHEBI:26710	denotes	NaCl
T12038	48717-48722	GO:0019835	denotes	lysed
T12039	48843-48854	CHEBI:16856	denotes	glutathione
T12040	48888-48892	CHEBI:9754	denotes	Tris
T12041	48893-48896	CHEBI:17883	denotes	HCl
T12042	48912-48916	CHEBI:26710	denotes	NaCl
T12043	49065-49076	GO:0006412	denotes	translation
T12044	49120-49123	CHEBI:37983	denotes	35S
T12045	49196-49206	GO:0006412	denotes	translated
T12046	49238-49242	CHEBI:9754	denotes	Tris
T12047	49243-49246	CHEBI:17883	denotes	HCl
T12048	49262-49266	CHEBI:26710	denotes	NaCl
T12049	49326-49331	PR:000016007	denotes	TACC2
T12050	49411-49415	CHEBI:9754	denotes	Tris
T12051	49416-49419	CHEBI:17883	denotes	HCl
T12052	49435-49439	CHEBI:26710	denotes	NaCl
T12053	49557-49561	CHEBI:9754	denotes	Tris
T12054	49562-49565	CHEBI:17883	denotes	HCl
T12055	49588-49599	CHEBI:16856	denotes	glutathione
T12056	49636-49639	CHEBI:8984	denotes	SDS
T12458	6583-6588	PR:000001856	denotes	RHAMM
T12565	16182-16188	SO:0000987	denotes	Linear
T12566	16205-16209	SO:0000704	denotes	gene
T12567	16267-16272	SO:0000704	denotes	genes
T12568	16276-16282	NCBITaxon:9606	denotes	humans
T12569	16284-16294	SO:0000859	denotes	Paralogous
T12570	16295-16300	SO:0000704	denotes	genes
T12571	16394-16398	PR:000008212	denotes	GPX3
T12572	16403-16408	PR:000011245	denotes	NKX2E
T12573	16477-16482	SO:0000704	denotes	genes
T12574	16544-16549	SO:0000704	denotes	genes
T12575	16585-16593	_FRAGMENT	denotes	syntenic
T12576	16612-16619	SO:0005858	denotes	regions
T12577	16594-16599	NCBITaxon:10088	denotes	mouse
T12578	16641-16658	NCBITaxon:31033	denotes	Takifugu rubripes
T12579	16659-16668	SO:0001248	denotes	scaffolds
T12580	16712-16722	SO:0000857	denotes	homologous
T12581	16723-16727	SO:0000704	denotes	gene
T12582	16784-16794	SO:0000859	denotes	paralogous
T12583	16795-16800	SO:0000704	denotes	genes
T12757	20814-20831	NCBITaxon:31033	denotes	Takifugu rubripes
T12758	20836-20854	NCBITaxon:7719	denotes	Ciona intestinalis
T12759	20878-20885	SO:0001026	denotes	genomic
T12760	20886-20895	SO:0001248	denotes	scaffolds
T12761	20911-20928	NCBITaxon:31033	denotes	Takifugu rubripes
T12762	20951-20956	SO:0000704	denotes	genes
T12763	20958-20966	SO:0001248	denotes	Scaffold
T12764	20997-21001	SO:0000704	denotes	gene
T12765	21011-21016	SO:0000704	denotes	genes
T12766	21035-21045	SO:0000853	denotes	homologues
T12767	21049-21060	SO:0000855	denotes	orthologues
T12768	21080-21086	_FRAGMENT	denotes	arm of
T12769	21093-21103	SO:0000105	denotes	chromosome
T12770	21087-21092	NCBITaxon:9606	denotes	human
T12771	21122-21130	SO:0001248	denotes	scaffold
T12772	21218-21223	PR:000016006	denotes	TACC1
T12773	21224-21229	PR:000016007	denotes	TACC2
T12774	21272-21280	SO:0001248	denotes	scaffold
T12775	21301-21312	SO:0000855	denotes	orthologues
T12776	21316-21321	SO:0000704	denotes	genes
T12777	21350-21356	_FRAGMENT	denotes	arm of
T12778	21363-21373	SO:0000105	denotes	chromosome
T12779	21357-21362	NCBITaxon:9606	denotes	human
T12780	21382-21400	NCBITaxon:7719	denotes	Ciona intestinalis
T12781	21421-21426	SO:0000704	denotes	genes
T12782	21436-21455	SO:0000854	denotes	paralogous segments
T12783	21459-21464	NCBITaxon:9606	denotes	human
T12956	21496-21503	SO:0001026	denotes	Genomic
T12957	21526-21531	SO:0000704	denotes	genes
T12958	21588-21593	NCBITaxon:9606	denotes	human
T12959	21637-21642	NCBITaxon:9606	denotes	human
T12960	21643-21648	PR:000016006	denotes	TACC1
T12961	21668-21673	PR:000017527	denotes	GAS41
T12962	21712-21718	SO:0000417	denotes	domain
T12963	21725-21731	PR:000005512	denotes	ch-TOG
T12964	21751-21765	PR:000035365	denotes	Aurora kinases
T12965	21773-21780	NCBITaxon:species	denotes	species
T12966	21850-21855	SO:0000147	denotes	exons
T12967	21868-21873	SO:0000704	denotes	genes
T12968	21899-21906	SO:0001060	denotes	isoform
T12969	21916-21920	SO:0000704	denotes	gene
T13128	27467-27487	GO:0000380	denotes	Alternative splicing
T13129	27495-27500	NCBITaxon:9606	denotes	human
T13130	27501-27506	PR:000016006	denotes	TACC1
T13131	27507-27511	SO:0000704	denotes	gene
T13132	27524-27530	GO:0008380	denotes	splice
T13133	27565-27570	NCBITaxon:9606	denotes	human
T13134	27571-27576	PR:000016006	denotes	TACC1
T13135	27625-27631	GO:0008380	denotes	splice
T13136	27693-27698	NCBITaxon:9606	denotes	human
T13137	27699-27704	UBERON:0000955	denotes	brain
T13138	27715-27735	GO:0000380	denotes	Alternative splicing
T13139	27739-27744	PR:000016006	denotes	TACC1
T13140	27752-27757	NCBITaxon:9606	denotes	human
T13141	27758-27763	UBERON:0000955	denotes	brain
T13142	27790-27798	GO:0008380	denotes	splicing
T13143	27806-27823	SO:0000198	denotes	untranslated exon
T13144	27808-27818	GO:0006412	denotes	translated
T13145	27830-27834	SO:0000147	denotes	exon
T13146	27940-27944	SO:0000147	denotes	Exon
T13147	27953-27960	GO:0008380	denotes	splices
T13148	27964-27968	SO:0000147	denotes	exon
T13149	27985-27990	PR:000009965	denotes	L-Sm7
T13150	28071-28076	SO:0000147	denotes	exons
T13151	28143-28150	GO:0005634	denotes	nuclear
T13152	28143-28171	SO:0001528	denotes	nuclear localization signals
T13153	28189-28196	SO:0000417	denotes	domains
T13154	28201-28206	PR:000017527	denotes	GAS41
T13155	28211-28221	PR:000029784	denotes	PCTAIRE2BP
T13156	28260-28266	SO:0000417	denotes	domain
T13157	28307-28313	PR:000005512	denotes	ch-TOG
T13158	28318-28333	PR:000004515	denotes	Aurora A kinase
T13159	28341-28351	GO:0005813	denotes	centrosome
T13564	31859-31869	NCBITaxon:6239	denotes	C. elegans
T13565	31874-31889	NCBITaxon:7227	denotes	D. melanogaster
T13566	31896-31906	NCBITaxon:6239	denotes	C. elegans
T13567	32119-32128	GO:0000785	denotes	chromatin
T13568	32119-32139	GO:0006338	denotes	chromatin remodeling
T13569	32140-32149	GO:0032991	denotes	complexes
T13570	32151-32158	GO:0016514	denotes	SWI/SNF
T13571	32163-32170	PR:000043452	denotes	histone
T13572	32163-32170	CHEBI:15358	denotes	histone
T13573	32192-32209	GO:0006281	denotes	DNA damage repair
T13574	32237-32249	GO:0008380	denotes	RNA splicing
T13575	32237-32240	_FRAGMENT	denotes	RNA
T13576	32251-32260	GO:0050658	denotes	transport
T13577	32265-32278	GO:0006412	denotes	translational
T13578	32325-32335	NCBITaxon:7742	denotes	vertebrate
T13579	32403-32410	GO:0005634	denotes	nuclear
T13580	32428-32432	PR:000014373	denotes	RXRβ
T13581	32573-32592	SO:0000854	denotes	paralogous segments
T13582	32694-32704	NCBITaxon:7742	denotes	Vertebrate
T13583	32799-32809	NCBITaxon:7742	denotes	vertebrate
T13584	32810-32819	SO:0000853	denotes	homologue
T13585	32883-32896	PR:000035365	denotes	Aurora kinase
T13853	38453-38459	PR:000016007	denotes	TACC2s
T13854	38494-38497	CHEBI:8984	denotes	SDS
T13855	38531-38541	GO:0006412	denotes	translated
T13856	38579-38584	PR:000016007	denotes	TACC2
T13857	38640-38650	GO:0006412	denotes	translated
T13858	38651-38656	PR:000014373	denotes	RXR-β
T13859	38769-38774	PR:000016007	denotes	TACC2
T12454	6304-6315	SO:0001080	denotes	coiled coil
T12455	6449-6460	SO:0001080	denotes	coiled coil
T12456	6502-6513	SO:0001080	denotes	coiled coil
T12457	6545-6550	PR:000001856	denotes	RHAMM
T6962	30756-30762	GO:0030674	denotes	bridge
T6963	30794-30806	GO:0005856	denotes	cytoskeleton
T6964	30811-30822	GO:0005874	denotes	microtubule
T6965	30864-30872	GO:0005840	denotes	ribosome
T6966	30878-30885	PR:000043452	denotes	histone
T6967	30878-30885	CHEBI:15358	denotes	histone
T6968	30898-30907	GO:0000785	denotes	chromatin
T6969	30898-30918	GO:0006338	denotes	chromatin remodeling
T6970	30937-30942	PR:000006937	denotes	egr-1
T6971	30947-30953	PR:P90916	denotes	lin-53
T6972	30959-30969	NCBITaxon:6239	denotes	C. elegans
T6973	30970-30980	SO:0000853	denotes	homologues
T6974	30988-30993	NCBITaxon:9606	denotes	human
T6975	30994-30999	PR:000010707	denotes	MTA-1
T6976	31004-31010	PR:000013776	denotes	RbAP48
T6977	31054-31058	PR:P34766	denotes	PAL1
T6978	31076-31083	GO:0005634	denotes	nuclear
T6979	31101-31107	PR:Q965W2	denotes	nhr-86
T6980	31178-31188	NCBITaxon:7215	denotes	Drosophila
T6981	31304-31314	NCBITaxon:7215	denotes	Drosophila
T6982	31315-31351	GO:0016514	denotes	SWI/SNF chromatin remodeling complex
T6983	31323-31343	GO:0006338	denotes	chromatin remodeling
T1333	5640-5657	NCBITaxon:7165	denotes	Anopheles gambiae
T1334	5727-5732	SO:0000704	denotes	genes
T1335	5736-5744	NCBITaxon:33208	denotes	metazoan
T1336	5804-5810	SO:0001026	denotes	genome
T1421	9589-9594	NCBITaxon:10088	denotes	mouse
T1422	9671-9691	SO:0000043	denotes	processed pseudogene
T1423	9704-9709	PR:000016006	denotes	TACC1
T1424	9710-9721	SO:0000336	denotes	pseudogenes
T1425	9780-9785	NCBITaxon:9606	denotes	human
T1426	9862-9864	SO:0000028	denotes	bp
T1427	9872-9877	PR:000016006	denotes	TACC1
T1428	9878-9900	SO:0000205	denotes	3' untranslated region
T1429	9883-9893	GO:0006412	denotes	translated
T1430	9905-9916	SO:0000336	denotes	pseudogenes
T1431	9934-9939	PR:000016007	denotes	TACC2
T1432	9943-9948	PR:000016008	denotes	TACC3
T1433	9972-9981	NCBITaxon:40674	denotes	mammalian
T1434	9982-9989	NCBITaxon:species	denotes	species
T3801	14654-14659	SO:0000704	denotes	genes
T3802	14694-14699	SO:0000704	denotes	genes
T3803	14730-14740	NCBITaxon:7742	denotes	vertebrate
T3804	14741-14746	PR:000016006	denotes	TACC1
T3805	14749-14754	SO:0000704	denotes	genes
T3860	17578-17585	SO:0001026	denotes	genomic
T3861	17586-17594	SO:0001248	denotes	scaffold
T3862	17646-17651	NCBITaxon:9606	denotes	human
T3863	17652-17663	SO:0000855	denotes	orthologues
R8156	T12576	T12575	_lexicallyChainedTo	regions,syntenic
R8278	T12769	T12768	_lexicallyChainedTo	chromosome,arm of
R311	T590	T589	_lexicallyChainedTo	chromosome,arm of
R312	T593	T592	_lexicallyChainedTo	regions,paralogous
R2434	T3812	T3811	_lexicallyChainedTo	segments,paralogous
R2435	T3819	T3818	_lexicallyChainedTo	segments,paralogous
R2436	T3908	T3907	_lexicallyChainedTo	segment,paralogous
R2437	T3914	T3913	_lexicallyChainedTo	segments,paralogous
R4060	T6249	T6248	_lexicallyChainedTo	organism,development of
R4061	T6299	T6298	_lexicallyChainedTo	metabolism,cellular
R4424	T6960	T6959	_lexicallyChainedTo	lin36,C. elegans
R5171	T8117	T8116	_lexicallyChainedTo	protein,binding site for
R5172	T8120	T8119	_lexicallyChainedTo	translation,control of
R5173	T8138	T8137	_lexicallyChainedTo	transport,RNA
R6476	T10051	T10050	_lexicallyChainedTo	segments,paralogous
R8279	T12778	T12777	_lexicallyChainedTo	chromosome,arm of
R8789	T13576	T13575	_lexicallyChainedTo	transport,RNA

2_test

Id	Subject	Object	Predicate	Lexical cue
15207008-10435627-9665981	3260-3261	10435627	denotes	1
15207008-10435627-9665982	3463-3464	10435627	denotes	1
15207008-10366448-9665982	3463-3464	10366448	denotes	1
15207008-12620397-9665982	3463-3464	12620397	denotes	1
15207008-10637228-9665983	3610-3611	10637228	denotes	4
15207008-12956952-9665983	3610-3611	12956952	denotes	4
15207008-12956951-9665983	3610-3611	12956951	denotes	4
15207008-10435627-9665984	4224-4225	10435627	denotes	1
15207008-10366448-9665984	4224-4225	10366448	denotes	1
15207008-12620397-9665984	4224-4225	12620397	denotes	1
15207008-11025203-9665985	4252-4253	11025203	denotes	7
15207008-10635326-9665986	4272-4273	10635326	denotes	8
15207008-10637228-9665987	4293-4294	10637228	denotes	4
15207008-12956952-9665988	4313-4314	12956952	denotes	5
15207008-12956951-9665989	4315-4316	12956951	denotes	6
15207008-12015314-9665990	4407-4408	12015314	denotes	9
15207008-12808028-9665991	4427-4429	12808028	denotes	10
15207008-12481130-9665992	6850-6852	12481130	denotes	11
15207008-11752271-9665993	6941-6943	11752271	denotes	12
15207008-12015314-9665994	10731-10732	12015314	denotes	9
15207008-12015314-9665995	10919-10920	12015314	denotes	9
15207008-10366448-9665996	11389-11390	10366448	denotes	2
15207008-12015314-9665997	11781-11782	12015314	denotes	9
15207008-12015314-9665998	12047-12048	12015314	denotes	9
15207008-12808028-9665999	13327-13329	12808028	denotes	10
15207008-12777526-9666000	14993-14995	12777526	denotes	13
15207008-12808028-9666001	15782-15784	12808028	denotes	10
15207008-12481130-9666002	17068-17070	12481130	denotes	11
15207008-12142439-9666003	17155-17157	12142439	denotes	14
15207008-12481130-9666004	19495-19497	12481130	denotes	11
15207008-11903063-9666005	23686-23688	11903063	denotes	15
15207008-11756182-9666006	23689-23691	11756182	denotes	16
15207008-10366448-9666007	24482-24483	10366448	denotes	2
15207008-10366448-9666008	24919-24920	10366448	denotes	2
15207008-11025203-9666009	24921-24922	11025203	denotes	7
15207008-12237944-9666010	24923-24925	12237944	denotes	17
15207008-11025203-9666011	25196-25197	11025203	denotes	7
15207008-10635326-9666012	25478-25479	10635326	denotes	8
15207008-12620397-9666013	26109-26110	12620397	denotes	3
15207008-12620397-9666014	26241-26242	12620397	denotes	3
15207008-12547166-9666015	26532-26534	12547166	denotes	18
15207008-12165861-9666016	26535-26537	12165861	denotes	19
15207008-14603251-9666017	26819-26821	14603251	denotes	20
15207008-11903063-9666018	26913-26915	11903063	denotes	15
15207008-14603251-9666019	26933-26935	14603251	denotes	20
15207008-12165861-9666020	27029-27031	12165861	denotes	19
15207008-12547166-9666021	27452-27454	12547166	denotes	18
15207008-14602875-9666022	29219-29221	14602875	denotes	21
15207008-12956952-9666023	29391-29392	12956952	denotes	5
15207008-12956951-9666024	29393-29394	12956951	denotes	6
15207008-12970190-9666025	29395-29397	12970190	denotes	22
15207008-12569123-9666025	29395-29397	12569123	denotes	22
15207008-11433296-9666025	29395-29397	11433296	denotes	22
15207008-14603251-9666026	29432-29434	14603251	denotes	20
15207008-14602875-9666027	29435-29437	14602875	denotes	21
15207008-11827981-9666028	29438-29440	11827981	denotes	25
15207008-12956952-9666029	29563-29564	12956952	denotes	5
15207008-12956951-9666030	29565-29566	12956951	denotes	6
15207008-12970190-9666031	29567-29569	12970190	denotes	22
15207008-12569123-9666031	29567-29569	12569123	denotes	22
15207008-11433296-9666031	29567-29569	11433296	denotes	22
15207008-14602875-9666032	29951-29953	14602875	denotes	21
15207008-11903063-9666033	30182-30184	11903063	denotes	15
15207008-12711550-9666034	30185-30187	12711550	denotes	26
15207008-11121038-9666035	30188-30190	11121038	denotes	27
15207008-10615043-9666036	30736-30738	10615043	denotes	28
15207008-10615043-9666037	31109-31111	10615043	denotes	28
15207008-12519993-9666038	31159-31161	12519993	denotes	29
15207008-14711411-9666039	31535-31537	14711411	denotes	30
15207008-7745706-9666040	33707-33709	7745706	denotes	31
15207008-14667816-9666041	33710-33712	14667816	denotes	32
15207008-12620397-9666042	34534-34535	12620397	denotes	3
15207008-12956952-9666043	34536-34537	12956952	denotes	5
15207008-12956951-9666043	34536-34537	12956951	denotes	5
15207008-11025203-9666043	34536-34537	11025203	denotes	5
15207008-11903063-9666044	34540-34542	11903063	denotes	15
15207008-12165861-9666045	34543-34545	12165861	denotes	19
15207008-14603251-9666045	34543-34545	14603251	denotes	19
15207008-14602875-9666045	34543-34545	14602875	denotes	19
15207008-11433296-9666046	34549-34551	11433296	denotes	24
15207008-11827981-9666047	34552-34554	11827981	denotes	25
15207008-11847113-9666048	34555-34557	11847113	denotes	33
15207008-14767476-9666049	34558-34560	14767476	denotes	34
15207008-12956952-9666050	34877-34878	12956952	denotes	5
15207008-12956951-9666051	34879-34880	12956951	denotes	6
15207008-14602875-9666052	34881-34883	14602875	denotes	21
15207008-12970190-9666052	34881-34883	12970190	denotes	21
15207008-12569123-9666052	34881-34883	12569123	denotes	21
15207008-11433296-9666052	34881-34883	11433296	denotes	21
15207008-11121038-9666053	35064-35066	11121038	denotes	27
15207008-14602875-9666054	35204-35206	14602875	denotes	21
15207008-10635326-9666055	35596-35597	10635326	denotes	8
15207008-11081630-9666056	35598-35600	11081630	denotes	35
15207008-12165861-9666057	36015-36017	12165861	denotes	19
15207008-12620397-9666058	36207-36208	12620397	denotes	3
15207008-14767476-9666059	36209-36211	14767476	denotes	34
15207008-14767476-9666060	36353-36355	14767476	denotes	34
15207008-11025203-9666061	37298-37299	11025203	denotes	7
15207008-12620397-9666062	37468-37469	12620397	denotes	3
15207008-11903063-9666063	37470-37472	11903063	denotes	15
15207008-14602875-9666064	39175-39177	14602875	denotes	21
15207008-12970190-9666065	39178-39180	12970190	denotes	22
15207008-11025203-9666066	40153-40154	11025203	denotes	7
15207008-11847113-9666067	40241-40243	11847113	denotes	33
15207008-14767476-9666068	40346-40348	14767476	denotes	34
15207008-14767476-9666069	40685-40687	14767476	denotes	34
15207008-12165861-9666070	40839-40841	12165861	denotes	19
15207008-12620397-9666071	41486-41487	12620397	denotes	3
15207008-14767476-9666072	41488-41490	14767476	denotes	34
15207008-12620397-9666073	41571-41572	12620397	denotes	3
15207008-2231712-9666074	41903-41905	2231712	denotes	36
15207008-11752248-9666075	42048-42050	11752248	denotes	37
15207008-12015314-9666076	43103-43104	12015314	denotes	9
15207008-9810230-9666077	47622-47624	9810230	denotes	38
15207008-8902363-9666078	47958-47960	8902363	denotes	39
15207008-3071258-9666079	48120-48122	3071258	denotes	40

PMC:441373 JSONTXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

craft-ca-core-ex-dev

craft-ca-core-dev

2_test

PMC:441373 JSON TXT