PMC:4342829 / 2006-2697 JSONTXT

{"project":"2_test","denotations":[{"id":"25880925-24534671-14893480","span":{"begin":386,"end":387},"obj":"24534671"},{"id":"25880925-24747045-14893481","span":{"begin":602,"end":603},"obj":"24747045"},{"id":"25880925-24882812-14893482","span":{"begin":688,"end":689},"obj":"24882812"}],"text":"Systems biology aims at understanding the organization of complex biological systems with a combination of mathematical modelling, experiments, and advanced computational tools. To describe the behaviour of complex systems, models with sufficient level of detail to provide mechanistic explanations are needed. This leads to the use of large-scale dynamic models of cellular processes [1]. By incorporating kinetic information, the range of applications of biological models can be widened. The importance of kinetic models is being increasingly acknowledged in fields such as bioprocess optimization [2], metabolic engineering [3], physiology, as well as cell and developmental biology [4]."}