PMC:4331679 / 29480-30795 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4331679","sourcedb":"PMC","sourceid":"4331679","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4331679","text":"Sensitivity analysis of the model\nTo analyse the behaviour of our model with respect to the fluctuations in model parameters, we verified our model by performing sensitivity analysis for the rate constants. We initially tested apoptosis level for each of the molecules by reducing the parameter by 30%. Then we increased the parameter by 30%. Among all the parameters, \"Casp3-Casp8\" and \"Casp3-Apop\", were found to be very sensitive, affecting the apoptosis level to the maximum. We found that the level of apoptosis for most of the parameters changed only slightly, within +/-5%, except for the most sensitive parameters, \"Casp3-Casp8\" and \"Casp3-Apop\", which affected the level of apoptosis by +/-20%.\nTo test the robustness of our model, we also performed the perturbation test. We changed the initial concentration of each of the molecules and identified the most sensitive parameters of the model. The apoptosis level was predicted for each of the molecule whose initial concentration was reduced by 30%. Then, for each molecule we increased the initial concentration by 30%. We found that the level of apoptosis for most of the initial concentrations was stable, except for the concentration of the molecules with parameters of \"Casp3-Casp8\" and \"Casp3-Apop\". This suggests an overall robustness of our model.","divisions":[{"label":"title","span":{"begin":0,"end":33}},{"label":"p","span":{"begin":34,"end":703}}],"tracks":[]}