PMC:4331678 / 19532-20071 JSONTXT

{"project":"2_test","denotations":[{"id":"25707434-20507895-14839082","span":{"begin":21,"end":23},"obj":"20507895"}],"text":"Mostafavi et al. [15,16] first utilized Eq. (4) to determine α for the individual networks, and then applied a Gaussian Random Field classifier [33] on the composite network W to predict protein functions. However, the composite network W optimized from the target network K is not necessarily optimal for the classifier, since the optimization of the composite network and of the classifier is divided into two separate objectives. To avoid this limitation, we attempt to integrate these two objectives into a unified function as follows:"}