PMC:4331677 / 6478-7253 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4331677","sourcedb":"PMC","sourceid":"4331677","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4331677","text":"However, most of the existed methods consider the target as a whole, resulting that it is difficult to investigate the latent binding mechanism between target and ligand. In other words, we know little about how the chemical space interacts with the genomic space. In this article, based on the fact that the target-ligand interaction is more of a local event, we use the binding sites (local information) instead of the whole target to describe the genomic space. Furthermore, we assume that the fragment-fragment interactions determine the target-ligand interactions. Thus we break the binding sites and ligands into fragments, and propose fragment interaction model (FIM) to figure out a clean picture of how the chemical space interacts with the genomic space (Figure 1).","tracks":[]}