PMC:4331677 / 26960-27879 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4331677","sourcedb":"PMC","sourceid":"4331677","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4331677","text":"An obvious feature of the fragment interaction matrix (Figure 5A) is that the values can be positive and negative, which means some fragment interactions are in favor of binding, and others not. Another obvious feature is that most of the values are close to zeros, which means the connections between site and ligand fragments are sparse. The sparse connection implies a site fragment only could recognize a small number of ligand fragments, which could reflect the specificity during the target-ligand binding procedure. Although there are 148653 (199 ∗ 747) elements in the matrix, only those whose value is larger than 0.1 are viewed as significant (the average standard error is 0.1). As a result, there are 9243 significant interactions in the network. During the significant interactions, the interaction values larger than 0.25 (top 20%) are regarded as import. Figure 5B shows the import fragment interactions.","tracks":[]}