PMC:4331677 / 23664-24390 JSONTXT

{"project":"2_test","denotations":[{"id":"25707321-7265238-14839525","span":{"begin":445,"end":447},"obj":"7265238"}],"text":"Because the intensity of intermolecular interaction decreases rapidly with the increasing distance, we can infer that local information may dominate the binding procedure. However, the local binding sites are inevitably influenced by the other part of target. We adopt the target sequence, obtained from the KEGG database [24], similarity score as global information. The sequence similarities are measured in nor-malized Smith-Waterman scores [25]. Kglo(t,t′)=SWt,t′/SW(t,t),SW(t′,t′) where t and t' are protein sequences, SW (·, ·) is the original Smith-Waterman s-core, and Kglo is a target global similarity matrix (global information). Finally, the global and local information are integrated by kernel trick, as follows:"}