PMC:4331676 / 2172-3570 JSONTXT

{"project":"2_test","denotations":[{"id":"25708928-23437146-14842616","span":{"begin":820,"end":821},"obj":"23437146"},{"id":"25708928-11125145-14842617","span":{"begin":932,"end":933},"obj":"11125145"},{"id":"25708928-18388294-14842618","span":{"begin":1008,"end":1009},"obj":"18388294"},{"id":"25708928-16056220-14842618","span":{"begin":1008,"end":1009},"obj":"16056220"},{"id":"25708928-16081699-14842618","span":{"begin":1008,"end":1009},"obj":"16081699"},{"id":"25708928-18421352-14842618","span":{"begin":1008,"end":1009},"obj":"18421352"},{"id":"25708928-16381880-14842619","span":{"begin":1206,"end":1207},"obj":"16381880"},{"id":"25708928-23396756-14842620","span":{"begin":1208,"end":1209},"obj":"23396756"},{"id":"25708928-16381842-14842621","span":{"begin":1317,"end":1319},"obj":"16381842"}],"text":"DNA-binding proteins are pivotal to the cell functions such as DNA replication, transcriptional regulation, packaging recombination, DNA repair, DNA modification and other fundamental activities associated with DNA. For example, in eukaryotic cells, histones which is a typical type of DNA-binding protein often help package chromosomal DNA into a compact structure, and as another typical DNA-binding protein, restriction enzymes are DNA-cutting enzymes found in bacteria that recognize and cut DNA only at a particular sequence of nucleotides to serve a host-defense role. DNA-binding proteins represent a broad category of proteins, known to be highly diverse in sequence and structure. Structurally, they have been divided into eight structural groups, which were further classified 54 protein structural families[1,2]. Functionally, protein-DNA interactions play various roles across the entire genome as previously mentioned [3]. The past decade has witnessed tremendous progress in genome sequencing [4-7]. According to the Genome On Line Database, the complete sequenced genomes of almost 1000 cellular organisms have been released, and about 5000 active genome sequencing projects are on the way [8,9]. The unprecedented amount of genetic information has provided hundreds of thousands of protein sequences [10], indicating that a challenging problem to elucidate their functions is posed."}