PMC:4331676 / 12565-13430 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4331676","sourcedb":"PMC","sourceid":"4331676","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4331676","text":"where L is the length of protein, the Si,j represents the occurrence probability of amino acid j at position i of the protein sequence, the rows of matrix represent the positions of the sequence and the columns of the matrix represent the 20 types original amino acids. PSSM scores are generally shown as positive or negative integers. Positive scores indicate that the given amino acid occurs more frequently in the alignment than expected by chance, while negative scores indicate that the given amino acid occurs less frequently than expected. Large positive scores often indicate critical functional residues, which may be active site residues or residues required for other intermolecular interactions. Therefore the element of PSSM profile can be used to approximately measure the occurrence probability of the corresponding amino acid at a specific position.","tracks":[]}