PMC:4307189 / 56458-59504 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4307189","sourcedb":"PMC","sourceid":"4307189","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4307189","text":"Additional files\nAdditional file 1 Appendix I. Derivation of p 1-model for directed network.\nAdditional file 2 Table S1. All 11,515 drug-resistant gene-pairs found in GSE38376.\nAdditional file 3 Table S2. All 1,083 (841 distinct) cross-talks found between EGFR and other 23 signaling pathways from Reactome database.\nAdditional file 4 Table S3. All 2,179 (1,050 distinct) cross-talks found between ErbB and other 34 signaling pathways from KEGG database.\nAdditional file 5 Table S4. All 3,084 (876 distinct) cross-talks found between ErbB and other 62 signaling pathways from WikiPathway database.\nAdditional file 6 Table S5. 104 drug-resistant cross-talks found between EGFR and other 23 signaling pathways from Reactome database [GSE38376].\nAdditional file 7 Table S6. 188 drug-resistant cross-talks found between ErbB and other 34 signaling pathways from KEGG database [GSE38376].\nAdditional file 8 Table S7. 299 drug-resistant cross-talks found between ErbB and other 62 signaling pathways from WikiPathway database [GSE38376].\nAdditional file 9 Table S8. 168 selected cross-talks which associated EGFR (or ErbB) signaling pathways with 6 other signaling pathways that were found in at least two different pathway analyses (i.e. Reactome and KEGG, or KEGG and WikiPathway, or Reactome and WikiPathway) [GSE38376].\nAdditional file 10 Table S9. All 10,811 drug-resistant gene-pairs found in GSE16179.\nAdditional file 11 Table S10. 83 drug-resistant cross-talks found between EGFR and other 23 signaling pathways from Reactome database [GSE16179].\nAdditional file 12 Table S11. 133 drug-resistant cross-talks found between ErbB and other 34 signaling pathways from KEGG database [GSE16179].\nAdditional file 13 Table S12. 278 drug-resistant cross-talks found between ErbB and other 62 signaling pathways from WikiPathway database [GSE16179].\nAdditional file 14 Table S13. 86 drug-resistant cross-talks found in all Reactome, KEGG and WikiPathway analyses where both genes in a particular cross-talk was up-regulated in resistant conditions but down-regulated in parental conditions [GSE16179].\nAdditional file 15 Table S14. 401 cross-talks from Reactome, KEGG and WikiPathway analyses where the genes are dysregulated in parental treatment vs parental basal condition, and reversely changed in resistant basal + resistant treatment vs parental basal condition [GSE16179]. Competing interests\nThe authors declare that they have no competing interests.\nAuthors’ contributions\nAKMA conceived the idea, collected datasets, designed and conducted experiments, analysed data and results, wrote the manuscript; JMK checked and approved the statistical model; AKMA validated the results and AL approved that validation; JMK and AL supervised this work and provided guidance in writing the manuscript. All authors read and approved the final manuscript.\n\nAcknowledgement\nThis research was supported by Monash International Postgraduate Research Scholarship and Monash Graduate Scholarship at the Monash University, Australia.","divisions":[{"label":"appendix","span":{"begin":0,"end":2401}},{"label":"sec","span":{"begin":0,"end":2401}},{"label":"title","span":{"begin":0,"end":16}},{"label":"p","span":{"begin":17,"end":94}},{"label":"label","span":{"begin":17,"end":34}},{"label":"caption","span":{"begin":36,"end":94}},{"label":"p","span":{"begin":36,"end":94}},{"label":"p","span":{"begin":95,"end":180}},{"label":"label","span":{"begin":95,"end":112}},{"label":"caption","span":{"begin":114,"end":180}},{"label":"p","span":{"begin":114,"end":180}},{"label":"p","span":{"begin":181,"end":322}},{"label":"label","span":{"begin":181,"end":198}},{"label":"caption","span":{"begin":200,"end":322}},{"label":"p","span":{"begin":200,"end":322}},{"label":"p","span":{"begin":323,"end":462}},{"label":"label","span":{"begin":323,"end":340}},{"label":"caption","span":{"begin":342,"end":462}},{"label":"p","span":{"begin":342,"end":462}},{"label":"p","span":{"begin":463,"end":607}},{"label":"label","span":{"begin":463,"end":480}},{"label":"caption","span":{"begin":482,"end":607}},{"label":"p","span":{"begin":482,"end":607}},{"label":"p","span":{"begin":608,"end":754}},{"label":"label","span":{"begin":608,"end":625}},{"label":"caption","span":{"begin":627,"end":754}},{"label":"p","span":{"begin":627,"end":754}},{"label":"p","span":{"begin":755,"end":897}},{"label":"label","span":{"begin":755,"end":772}},{"label":"caption","span":{"begin":774,"end":897}},{"label":"p","span":{"begin":774,"end":897}},{"label":"p","span":{"begin":898,"end":1047}},{"label":"label","span":{"begin":898,"end":915}},{"label":"caption","span":{"begin":917,"end":1047}},{"label":"p","span":{"begin":917,"end":1047}},{"label":"p","span":{"begin":1048,"end":1335}},{"label":"label","span":{"begin":1048,"end":1065}},{"label":"caption","span":{"begin":1067,"end":1335}},{"label":"p","span":{"begin":1067,"end":1335}},{"label":"p","span":{"begin":1336,"end":1422}},{"label":"label","span":{"begin":1336,"end":1354}},{"label":"caption","span":{"begin":1356,"end":1422}},{"label":"p","span":{"begin":1356,"end":1422}},{"label":"p","span":{"begin":1423,"end":1570}},{"label":"label","span":{"begin":1423,"end":1441}},{"label":"caption","span":{"begin":1443,"end":1570}},{"label":"p","span":{"begin":1443,"end":1570}},{"label":"p","span":{"begin":1571,"end":1715}},{"label":"label","span":{"begin":1571,"end":1589}},{"label":"caption","span":{"begin":1591,"end":1715}},{"label":"p","span":{"begin":1591,"end":1715}},{"label":"p","span":{"begin":1716,"end":1867}},{"label":"label","span":{"begin":1716,"end":1734}},{"label":"caption","span":{"begin":1736,"end":1867}},{"label":"p","span":{"begin":1736,"end":1867}},{"label":"p","span":{"begin":1868,"end":2121}},{"label":"label","span":{"begin":1868,"end":1886}},{"label":"caption","span":{"begin":1888,"end":2121}},{"label":"p","span":{"begin":1888,"end":2121}},{"label":"p","span":{"begin":2122,"end":2401}},{"label":"label","span":{"begin":2122,"end":2140}},{"label":"caption","span":{"begin":2142,"end":2401}},{"label":"p","span":{"begin":2142,"end":2401}},{"label":"footnote","span":{"begin":2402,"end":2480}},{"label":"p","span":{"begin":2402,"end":2422}},{"label":"p","span":{"begin":2422,"end":2480}},{"label":"footnote","span":{"begin":2481,"end":2874}},{"label":"p","span":{"begin":2481,"end":2504}},{"label":"p","span":{"begin":2504,"end":2874}},{"label":"title","span":{"begin":2876,"end":2891}}],"tracks":[]}