PMC:4307189 / 55816-56456
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4307189","sourcedb":"PMC","sourceid":"4307189","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4307189","text":"Conclusions\nOur proposed computational framework is able to predict putative cross-talks among signaling pathways that play a role in drug resistance in two breast cancer cell-lines, SKBR3 and BT474. Our framework could also be useful for other types of cancer to enhance understanding of the role of signaling cross-talks in drug resistance. Most importantly, we believe our method can be used to find a range of compensatory pathways that nullify/reduce the inhibiting effects of drugs via cross-talk with targeted pathways. These novel compensatory pathways can be further considered as novel targets for single or combination therapies.","divisions":[{"label":"title","span":{"begin":0,"end":11}}],"tracks":[]}